@prefix AGRKB: <https://www.alliancegenome.org/> .
@prefix CHADO: <http://gmod.org/wiki/Chado/> .
@prefix CHEMBL.MECHANISM: <https://www.ebi.ac.uk/chembl/mechanism/inspect/> .
@prefix CPT: <https://www.ama-assn.org/practice-management/cpt/> .
@prefix CTD: <http://ctdbase.org/> .
@prefix DGIdb: <https://www.dgidb.org/interaction_types> .
@prefix DOID-PROPERTY: <http://purl.obolibrary.org/obo/doid#> .
@prefix DrugCentral: <http://drugcentral.org/drugcard/> .
@prefix ECTO: <http://purl.obolibrary.org/obo/ECTO_> .
@prefix EDAM-DATA: <http://edamontology.org/data_> .
@prefix EFO: <http://www.ebi.ac.uk/efo/EFO_> .
@prefix ExO: <http://purl.obolibrary.org/obo/ExO_> .
@prefix FYPO: <http://purl.obolibrary.org/obo/FYPO_> .
@prefix GOP: <http://purl.obolibrary.org/obo/go#> .
@prefix GOREL: <http://purl.obolibrary.org/obo/GOREL_> .
@prefix HANCESTRO: <http://www.ebi.ac.uk/ancestro/ancestro_> .
@prefix HCPCS: <http://purl.bioontology.org/ontology/HCPCS/> .
@prefix HsapDv: <http://purl.obolibrary.org/obo/HsapDv_> .
@prefix IAO: <http://purl.obolibrary.org/obo/IAO_> .
@prefix INO: <http://purl.obolibrary.org/obo/INO_> .
@prefix LOINC: <http://loinc.org/rdf/> .
@prefix MAXO: <http://purl.obolibrary.org/obo/MAXO_> .
@prefix MESH: <http://id.nlm.nih.gov/mesh/> .
@prefix MI: <http://purl.obolibrary.org/obo/MI_> .
@prefix NBO-PROPERTY: <http://purl.obolibrary.org/obo/nbo#> .
@prefix NDDF: <http://purl.bioontology.org/ontology/NDDF/> .
@prefix OBAN: <http://purl.org/oban/> .
@prefix PHAROS: <http://pharos.nih.gov> .
@prefix PathWhiz: <http://smpdb.ca/pathways/#> .
@prefix REPODB: <http://apps.chiragjpgroup.org/repoDB/> .
@prefix RO: <http://purl.obolibrary.org/obo/RO_> .
@prefix RXNORM: <http://purl.bioontology.org/ontology/RXNORM/> .
@prefix SEMMEDDB: <https://skr3.nlm.nih.gov/SemMedDB> .
@prefix SIO: <http://semanticscience.org/resource/SIO_> .
@prefix SNOMEDCT: <http://snomed.info/id/> .
@prefix STY: <http://purl.bioontology.org/ontology/STY/> .
@prefix UBERGRAPH: <http://translator.renci.org/ubergraph-axioms.ofn#> .
@prefix UBERON_CORE: <http://purl.obolibrary.org/obo/uberon/core#> .
@prefix UBERON_NONAMESPACE: <http://purl.obolibrary.org/obo/core#> .
@prefix UMLSSG: <https://lhncbc.nlm.nih.gov/semanticnetwork/download/sg_archive/SemGroups-v04.txt> .
@prefix UO-PROPERTY: <http://purl.obolibrary.org/obo/uo#> .
@prefix VANDF: <https://www.nlm.nih.gov/research/umls/sourcereleasedocs/current/VANDF/> .
@prefix VMC: <https://github.com/ga4gh/vr-spec/> .
@prefix WBVocab: <http://bio2rdf.org/wormbase_vocabulary> .
@prefix WBbt: <http://purl.obolibrary.org/obo/WBBT_> .
@prefix WIKIDATA: <https://www.wikidata.org/wiki/> .
@prefix WIKIDATA_PROPERTY: <https://www.wikidata.org/wiki/Property:> .
@prefix XPO: <http://purl.obolibrary.org/obo/XPO_> .
@prefix biolink: <https://w3id.org/biolink/vocab/> .
@prefix bioschemas: <https://bioschemas.org/> .
@prefix dcat: <http://www.w3.org/ns/dcat#> .
@prefix dcid: <https://datacommons.org/browser/> .
@prefix dct: <http://purl.org/dc/terms/> .
@prefix foaf: <http://xmlns.com/foaf/0.1/> .
@prefix gff3: <https://github.com/The-Sequence-Ontology/Specifications/blob/master/gff3.md#> .
@prefix gpi: <https://github.com/geneontology/go-annotation/blob/master/specs/gpad-gpi-2-0.md#> .
@prefix linkml: <https://w3id.org/linkml/> .
@prefix oboformat: <http://www.geneontology.org/formats/oboInOwl#> .
@prefix orphanet: <http://www.orpha.net/ORDO/Orphanet_> .
@prefix os: <https://github.com/cmungall/owlstar/blob/master/owlstar.ttl> .
@prefix owl: <http://www.w3.org/2002/07/owl#> .
@prefix pav: <http://purl.org/pav/> .
@prefix prov: <http://www.w3.org/ns/prov#> .
@prefix qud: <http://qudt.org/1.1/schema/qudt#> .
@prefix rdf: <http://www.w3.org/1999/02/22-rdf-syntax-ns#> .
@prefix rdfs: <http://www.w3.org/2000/01/rdf-schema#> .
@prefix schema: <http://schema.org/> .
@prefix skos: <http://www.w3.org/2004/02/skos/core#> .
@prefix wgs: <http://www.w3.org/2003/01/geo/wgs84_pos> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://w3id.org/biolink/biolink-model.owl.ttl> a owl:Ontology ;
    rdfs:label "Biolink-Model" ;
    IAO:0000700 biolink:Annotation,
        biolink:CaseToEntityAssociationMixin,
        biolink:CellLineToEntityAssociationMixin,
        biolink:ChemicalEntityOrGeneOrGeneProduct,
        biolink:ChemicalEntityOrProteinOrPolypeptide,
        biolink:ChemicalEntityToEntityAssociationMixin,
        biolink:ChemicalOrDrugOrTreatment,
        biolink:DiseaseOrPhenotypicFeatureToEntityAssociationMixin,
        biolink:DiseaseToEntityAssociationMixin,
        biolink:Entity,
        biolink:EntityToDiseaseOrPhenotypicFeatureAssociationMixin,
        biolink:EntityToExposureEventAssociationMixin,
        biolink:EntityToOutcomeAssociationMixin,
        biolink:EpigenomicEntity,
        biolink:FrequencyQualifierMixin,
        biolink:GeneExpressionMixin,
        biolink:GeneGroupingMixin,
        biolink:GeneToEntityAssociationMixin,
        biolink:GenomicEntity,
        biolink:GenotypeToEntityAssociationMixin,
        biolink:MacromolecularMachineMixin,
        biolink:MacromolecularMachineToEntityAssociationMixin,
        biolink:MappingCollection,
        biolink:MaterialSampleToEntityAssociationMixin,
        biolink:ModelToDiseaseAssociationMixin,
        biolink:OntologyClass,
        biolink:OrganismTaxonToEntityAssociation,
        biolink:Outcome,
        biolink:PathologicalEntityMixin,
        biolink:PhysicalEssenceOrOccurrent,
        biolink:PredicateMapping,
        biolink:RelationshipQuantifier,
        biolink:SubjectOfInvestigation,
        biolink:ThingWithTaxon,
        biolink:VariantToEntityAssociationMixin ;
    dct:license "https://creativecommons.org/publicdomain/zero/1.0/" ;
    pav:version "3.2.0" ;
    linkml:generation_date "2023-02-07T19:40:59" ;
    linkml:metamodel_version "1.7.0" ;
    linkml:source_file "biolink-model.yaml" ;
    linkml:source_file_date "2023-02-07T19:39:37" ;
    linkml:source_file_size 335683 .

biolink:Activity a owl:Class ;
    rdfs:label "activity" ;
    rdfs:subClassOf biolink:ActivityAndBehavior,
        biolink:NamedThing ;
    skos:definition "An activity is something that occurs over a period of time and acts upon or with entities; it may include consuming, processing, transforming, modifying, relocating, using, or generating entities." ;
    skos:exactMatch STY:T052,
        <http://purl.obolibrary.org/obo/NCIT_C43431>,
        prov:Activity ;
    skos:narrowMatch STY:T056,
        STY:T057,
        STY:T058,
        STY:T062,
        STY:T064,
        STY:T065,
        STY:T066 .

biolink:AnatomicalEntityToAnatomicalEntityOntogenicAssociation a owl:Class ;
    rdfs:label "anatomical entity to anatomical entity ontogenic association" ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:onClass biolink:AnatomicalEntity ;
            owl:onProperty rdf:object ;
            owl:qualifiedCardinality 1 ],
        [ a owl:Restriction ;
            owl:onClass biolink:AnatomicalEntity ;
            owl:onProperty rdf:subject ;
            owl:qualifiedCardinality 1 ],
        [ a owl:Restriction ;
            owl:onClass biolink:PredicateType ;
            owl:onProperty rdf:predicate ;
            owl:qualifiedCardinality 1 ],
        biolink:AnatomicalEntityToAnatomicalEntityAssociation ;
    skos:definition "A relationship between two anatomical entities where the relationship is ontogenic, i.e. the two entities are related by development. A number of different relationship types can be used to specify the precise nature of the relationship." .

biolink:AnatomicalEntityToAnatomicalEntityPartOfAssociation a owl:Class ;
    rdfs:label "anatomical entity to anatomical entity part of association" ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:onClass biolink:AnatomicalEntity ;
            owl:onProperty rdf:subject ;
            owl:qualifiedCardinality 1 ],
        [ a owl:Restriction ;
            owl:onClass biolink:PredicateType ;
            owl:onProperty rdf:predicate ;
            owl:qualifiedCardinality 1 ],
        [ a owl:Restriction ;
            owl:onClass biolink:AnatomicalEntity ;
            owl:onProperty rdf:object ;
            owl:qualifiedCardinality 1 ],
        biolink:AnatomicalEntityToAnatomicalEntityAssociation ;
    skos:definition "A relationship between two anatomical entities where the relationship is mereological, i.e the two entities are related by parthood. This includes relationships between cellular components and cells, between cells and tissues, tissues and whole organisms" .

biolink:Article a owl:Class ;
    rdfs:label "article" ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:maxQualifiedCardinality 1 ;
            owl:onClass linkml:String ;
            owl:onProperty biolink:volume ],
        [ a owl:Restriction ;
            owl:onClass linkml:Uriorcurie ;
            owl:onProperty biolink:published_in ;
            owl:qualifiedCardinality 1 ],
        [ a owl:Restriction ;
            owl:maxQualifiedCardinality 1 ;
            owl:onClass linkml:String ;
            owl:onProperty biolink:iso_abbreviation ],
        [ a owl:Restriction ;
            owl:maxQualifiedCardinality 1 ;
            owl:onClass linkml:String ;
            owl:onProperty biolink:issue ],
        biolink:Publication .

biolink:BehaviorToBehavioralFeatureAssociation a owl:Class ;
    rdfs:label "behavior to behavioral feature association" ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:maxQualifiedCardinality 1 ;
            owl:onClass biolink:FrequencyValue ;
            owl:onProperty biolink:frequency_qualifier ],
        [ a owl:Restriction ;
            owl:maxQualifiedCardinality 1 ;
            owl:onClass linkml:Double ;
            owl:onProperty biolink:has_quotient ],
        [ a owl:Restriction ;
            owl:maxQualifiedCardinality 1 ;
            owl:onClass linkml:Integer ;
            owl:onProperty biolink:has_total ],
        [ a owl:Restriction ;
            owl:maxQualifiedCardinality 1 ;
            owl:onClass biolink:BiologicalSex ;
            owl:onProperty biolink:sex_qualifier ],
        [ a owl:Restriction ;
            owl:maxQualifiedCardinality 1 ;
            owl:onClass biolink:Onset ;
            owl:onProperty biolink:onset_qualifier ],
        [ a owl:Restriction ;
            owl:onClass biolink:Behavior ;
            owl:onProperty rdf:subject ;
            owl:qualifiedCardinality 1 ],
        [ a owl:Restriction ;
            owl:maxQualifiedCardinality 1 ;
            owl:onClass linkml:Double ;
            owl:onProperty biolink:has_percentage ],
        [ a owl:Restriction ;
            owl:maxQualifiedCardinality 1 ;
            owl:onClass biolink:SeverityValue ;
            owl:onProperty biolink:severity_qualifier ],
        [ a owl:Restriction ;
            owl:maxQualifiedCardinality 1 ;
            owl:onClass linkml:Integer ;
            owl:onProperty biolink:has_count ],
        [ a owl:Restriction ;
            owl:onClass biolink:BehavioralFeature ;
            owl:onProperty rdf:object ;
            owl:qualifiedCardinality 1 ],
        biolink:Association,
        biolink:EntityToPhenotypicFeatureAssociationMixin ;
    skos:definition "An association between an mixture behavior and a behavioral feature manifested by the individual exhibited or has exhibited the behavior." .

biolink:BehavioralExposure a owl:Class ;
    rdfs:label "behavioral exposure" ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:maxQualifiedCardinality 1 ;
            owl:onClass biolink:TimeType ;
            owl:onProperty biolink:timepoint ],
        biolink:Attribute,
        biolink:ExposureEvent ;
    skos:definition "A behavioral exposure is a factor relating to behavior impacting an individual." .

biolink:BehavioralOutcome a owl:Class ;
    rdfs:label "behavioral outcome" ;
    rdfs:subClassOf biolink:Outcome ;
    skos:definition "An outcome resulting from an exposure event which is the manifestation of human behavior." .

biolink:BioticExposure a owl:Class ;
    rdfs:label "biotic exposure" ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:maxQualifiedCardinality 1 ;
            owl:onClass biolink:TimeType ;
            owl:onProperty biolink:timepoint ],
        biolink:Attribute,
        biolink:ExposureEvent ;
    skos:altLabel "bacterial exposure",
        "viral exposure" ;
    skos:definition "An external biotic exposure is an intake of (sometimes pathological) biological organisms (including viruses)." .

biolink:Book a owl:Class ;
    rdfs:label "book" ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:onClass linkml:String ;
            owl:onProperty biolink:id ;
            owl:qualifiedCardinality 1 ],
        [ a owl:Restriction ;
            owl:allValuesFrom linkml:String ;
            owl:onProperty rdf:type ],
        biolink:Publication ;
    skos:definition "This class may rarely be instantiated except if use cases of a given knowledge graph support its utility." .

biolink:CaseToPhenotypicFeatureAssociation a owl:Class ;
    rdfs:label "case to phenotypic feature association" ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:maxQualifiedCardinality 1 ;
            owl:onClass biolink:Onset ;
            owl:onProperty biolink:onset_qualifier ],
        [ a owl:Restriction ;
            owl:maxQualifiedCardinality 1 ;
            owl:onClass biolink:SeverityValue ;
            owl:onProperty biolink:severity_qualifier ],
        [ a owl:Restriction ;
            owl:maxQualifiedCardinality 1 ;
            owl:onClass biolink:BiologicalSex ;
            owl:onProperty biolink:sex_qualifier ],
        [ a owl:Restriction ;
            owl:maxQualifiedCardinality 1 ;
            owl:onClass linkml:Integer ;
            owl:onProperty biolink:has_total ],
        [ a owl:Restriction ;
            owl:maxQualifiedCardinality 1 ;
            owl:onClass linkml:Integer ;
            owl:onProperty biolink:has_count ],
        [ a owl:Restriction ;
            owl:maxQualifiedCardinality 1 ;
            owl:onClass linkml:Double ;
            owl:onProperty biolink:has_quotient ],
        [ a owl:Restriction ;
            owl:maxQualifiedCardinality 1 ;
            owl:onClass biolink:FrequencyValue ;
            owl:onProperty biolink:frequency_qualifier ],
        [ a owl:Restriction ;
            owl:maxQualifiedCardinality 1 ;
            owl:onClass linkml:Double ;
            owl:onProperty biolink:has_percentage ],
        biolink:Association,
        biolink:CaseToEntityAssociationMixin,
        biolink:EntityToPhenotypicFeatureAssociationMixin ;
    skos:definition "An association between a case (e.g. individual patient) and a phenotypic feature in which the individual has or has had the phenotype." .

biolink:Cell a owl:Class ;
    rdfs:label "cell" ;
    rdfs:subClassOf biolink:AnatomicalEntity ;
    skos:exactMatch MESH:D002477,
        STY:T025,
        <http://purl.obolibrary.org/obo/CL_0000000>,
        <http://purl.obolibrary.org/obo/GO_0005623>,
        SIO:010001,
        WIKIDATA:Q7868 .

biolink:CellLineAsAModelOfDiseaseAssociation a owl:Class ;
    rdfs:label "cell line as a model of disease association" ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:maxQualifiedCardinality 1 ;
            owl:onClass biolink:FrequencyValue ;
            owl:onProperty biolink:frequency_qualifier ],
        [ a owl:Restriction ;
            owl:maxQualifiedCardinality 1 ;
            owl:onClass biolink:Onset ;
            owl:onProperty biolink:onset_qualifier ],
        [ a owl:Restriction ;
            owl:maxQualifiedCardinality 1 ;
            owl:onClass biolink:SeverityValue ;
            owl:onProperty biolink:severity_qualifier ],
        [ a owl:Restriction ;
            owl:onClass biolink:CellLine ;
            owl:onProperty rdf:subject ;
            owl:qualifiedCardinality 1 ],
        biolink:CellLineToDiseaseOrPhenotypicFeatureAssociation,
        biolink:EntityToDiseaseAssociationMixin,
        biolink:ModelToDiseaseAssociationMixin .

biolink:CellularOrganism a owl:Class ;
    rdfs:label "cellular organism" ;
    rdfs:subClassOf biolink:OrganismalEntity,
        biolink:SubjectOfInvestigation ;
    skos:definition "" ;
    skos:exactMatch <http://purl.obolibrary.org/obo/NCBITaxon_131567> .

biolink:ChemicalAffectsGeneAssociation a owl:Class ;
    rdfs:label "chemical affects gene association" ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:maxQualifiedCardinality 1 ;
            owl:onClass biolink:AnatomicalEntity ;
            owl:onProperty biolink:anatomical_context_qualifier ],
        [ a owl:Restriction ;
            owl:maxQualifiedCardinality 1 ;
            owl:onClass biolink:AnatomicalEntity ;
            owl:onProperty biolink:subject_context_qualifier ],
        [ a owl:Restriction ;
            owl:maxQualifiedCardinality 1 ;
            owl:onClass linkml:String ;
            owl:onProperty biolink:qualified_predicate ],
        [ a owl:Restriction ;
            owl:maxQualifiedCardinality 1 ;
            owl:onClass biolink:DirectionQualifierEnum ;
            owl:onProperty biolink:subject_direction_qualifier ],
        [ a owl:Restriction ;
            owl:maxQualifiedCardinality 1 ;
            owl:onClass biolink:AnatomicalEntity ;
            owl:onProperty biolink:object_context_qualifier ],
        [ a owl:Restriction ;
            owl:maxQualifiedCardinality 1 ;
            owl:onClass biolink:ChemicalOrGeneOrGeneProductFormOrVariantEnum ;
            owl:onProperty biolink:subject_form_or_variant_qualifier ],
        [ a owl:Restriction ;
            owl:onClass biolink:PredicateType ;
            owl:onProperty rdf:predicate ;
            owl:qualifiedCardinality 1 ],
        [ a owl:Restriction ;
            owl:maxQualifiedCardinality 1 ;
            owl:onClass biolink:GeneOrGeneProductOrChemicalPartQualifierEnum ;
            owl:onProperty biolink:subject_aspect_qualifier ],
        [ a owl:Restriction ;
            owl:maxQualifiedCardinality 1 ;
            owl:onClass biolink:CausalMechanismQualifierEnum ;
            owl:onProperty biolink:causal_mechanism_qualifier ],
        [ a owl:Restriction ;
            owl:onClass biolink:ChemicalEntity ;
            owl:onProperty rdf:subject ;
            owl:qualifiedCardinality 1 ],
        [ a owl:Restriction ;
            owl:maxQualifiedCardinality 1 ;
            owl:onClass biolink:OrganismTaxon ;
            owl:onProperty biolink:species_context_qualifier ],
        [ a owl:Restriction ;
            owl:maxQualifiedCardinality 1 ;
            owl:onClass biolink:DirectionQualifierEnum ;
            owl:onProperty biolink:object_direction_qualifier ],
        [ a owl:Restriction ;
            owl:maxQualifiedCardinality 1 ;
            owl:onClass biolink:GeneOrGeneProductOrChemicalPartQualifierEnum ;
            owl:onProperty biolink:subject_part_qualifier ],
        [ a owl:Restriction ;
            owl:maxQualifiedCardinality 1 ;
            owl:onClass biolink:GeneOrGeneProductOrChemicalPartQualifierEnum ;
            owl:onProperty biolink:object_part_qualifier ],
        [ a owl:Restriction ;
            owl:maxQualifiedCardinality 1 ;
            owl:onClass biolink:GeneOrGeneProductOrChemicalPartQualifierEnum ;
            owl:onProperty biolink:object_aspect_qualifier ],
        [ a owl:Restriction ;
            owl:onClass biolink:GeneOrGeneProduct ;
            owl:onProperty rdf:object ;
            owl:qualifiedCardinality 1 ],
        [ a owl:Restriction ;
            owl:maxQualifiedCardinality 1 ;
            owl:onClass biolink:ChemicalOrGeneOrGeneProductFormOrVariantEnum ;
            owl:onProperty biolink:object_form_or_variant_qualifier ],
        [ a owl:Restriction ;
            owl:maxQualifiedCardinality 1 ;
            owl:onClass biolink:ChemicalEntityDerivativeEnum ;
            owl:onProperty biolink:subject_derivative_qualifier ],
        biolink:Association ;
    skos:definition "Describes an effect that a chemical has on a gene or gene product (e.g. an impact of on its abundance, activity, localization, processing, expression, etc.)" .

biolink:ChemicalEntityAssessesNamedThingAssociation a owl:Class ;
    rdfs:label "chemical entity assesses named thing association" ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:onClass biolink:PredicateType ;
            owl:onProperty rdf:predicate ;
            owl:qualifiedCardinality 1 ],
        [ a owl:Restriction ;
            owl:onClass biolink:NamedThing ;
            owl:onProperty rdf:object ;
            owl:qualifiedCardinality 1 ],
        [ a owl:Restriction ;
            owl:onClass biolink:ChemicalEntity ;
            owl:onProperty rdf:subject ;
            owl:qualifiedCardinality 1 ],
        biolink:Association .

biolink:ChemicalEntityOrGeneOrGeneProductRegulatesGeneAssociation a owl:Class ;
    rdfs:label "chemical entity or gene or gene product regulates gene association" ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:onClass biolink:GeneOrGeneProduct ;
            owl:onProperty rdf:object ;
            owl:qualifiedCardinality 1 ],
        [ a owl:Restriction ;
            owl:onClass biolink:PredicateType ;
            owl:onProperty rdf:predicate ;
            owl:qualifiedCardinality 1 ],
        [ a owl:Restriction ;
            owl:onClass biolink:ChemicalEntityOrGeneOrGeneProduct ;
            owl:onProperty rdf:subject ;
            owl:qualifiedCardinality 1 ],
        [ a owl:Restriction ;
            owl:maxQualifiedCardinality 1 ;
            owl:onClass biolink:DirectionQualifierEnum ;
            owl:onProperty biolink:object_direction_qualifier ],
        biolink:Association ;
    skos:definition "A regulatory relationship between two genes" .

biolink:ChemicalGeneInteractionAssociation a owl:Class ;
    rdfs:label "chemical gene interaction association" ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:maxQualifiedCardinality 1 ;
            owl:onClass biolink:GeneOrGeneProductOrChemicalPartQualifierEnum ;
            owl:onProperty biolink:object_part_qualifier ],
        [ a owl:Restriction ;
            owl:maxQualifiedCardinality 1 ;
            owl:onClass biolink:ChemicalOrGeneOrGeneProductFormOrVariantEnum ;
            owl:onProperty biolink:subject_form_or_variant_qualifier ],
        [ a owl:Restriction ;
            owl:onClass biolink:PredicateType ;
            owl:onProperty rdf:predicate ;
            owl:qualifiedCardinality 1 ],
        [ a owl:Restriction ;
            owl:maxQualifiedCardinality 1 ;
            owl:onClass biolink:AnatomicalEntity ;
            owl:onProperty biolink:object_context_qualifier ],
        [ a owl:Restriction ;
            owl:maxQualifiedCardinality 1 ;
            owl:onClass biolink:GeneOrGeneProductOrChemicalPartQualifierEnum ;
            owl:onProperty biolink:subject_part_qualifier ],
        [ a owl:Restriction ;
            owl:maxQualifiedCardinality 1 ;
            owl:onClass biolink:AnatomicalEntity ;
            owl:onProperty biolink:subject_context_qualifier ],
        [ a owl:Restriction ;
            owl:maxQualifiedCardinality 1 ;
            owl:onClass biolink:ChemicalEntityDerivativeEnum ;
            owl:onProperty biolink:subject_derivative_qualifier ],
        [ a owl:Restriction ;
            owl:onClass biolink:ChemicalEntity ;
            owl:onProperty rdf:subject ;
            owl:qualifiedCardinality 1 ],
        [ a owl:Restriction ;
            owl:maxQualifiedCardinality 1 ;
            owl:onClass biolink:ChemicalOrGeneOrGeneProductFormOrVariantEnum ;
            owl:onProperty biolink:object_form_or_variant_qualifier ],
        [ a owl:Restriction ;
            owl:maxQualifiedCardinality 1 ;
            owl:onClass biolink:AnatomicalEntity ;
            owl:onProperty biolink:anatomical_context_qualifier ],
        [ a owl:Restriction ;
            owl:onClass biolink:GeneOrGeneProduct ;
            owl:onProperty rdf:object ;
            owl:qualifiedCardinality 1 ],
        biolink:Association,
        biolink:ChemicalToEntityAssociationMixin ;
    skos:definition "describes a physical interaction between a chemical entity and a gene or gene product. Any biological or chemical effect resulting from such an interaction are out of scope, and covered by the ChemicalAffectsGeneAssociation type (e.g. impact of a chemical on the abundance, activity, structure, etc, of either participant in the interaction)" ;
    skos:exactMatch SIO:001257 .

biolink:ChemicalOrDrugOrTreatmentSideEffectDiseaseOrPhenotypicFeatureAssociation a owl:Class ;
    rdfs:label "chemical or drug or treatment side effect disease or phenotypic feature association" ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:onClass biolink:PredicateType ;
            owl:onProperty rdf:predicate ;
            owl:qualifiedCardinality 1 ],
        biolink:ChemicalOrDrugOrTreatmentToDiseaseOrPhenotypicFeatureAssociation,
        biolink:ChemicalToEntityAssociationMixin,
        biolink:EntityToDiseaseOrPhenotypicFeatureAssociationMixin ;
    skos:definition "This association defines a relationship between a chemical or treatment (or procedure) and a disease or phenotypic feature where the disesae or phenotypic feature is a secondary, typically (but not always) undesirable effect." .

biolink:ChemicalToChemicalDerivationAssociation a owl:Class ;
    rdfs:label "chemical to chemical derivation association" ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:onClass biolink:PredicateType ;
            owl:onProperty rdf:predicate ;
            owl:qualifiedCardinality 1 ],
        [ a owl:Restriction ;
            owl:onClass biolink:ChemicalEntity ;
            owl:onProperty rdf:object ;
            owl:qualifiedCardinality 1 ],
        [ a owl:Restriction ;
            owl:allValuesFrom biolink:MacromolecularMachineMixin ;
            owl:onProperty biolink:catalyst_qualifier ],
        [ a owl:Restriction ;
            owl:onClass biolink:ChemicalEntity ;
            owl:onProperty rdf:subject ;
            owl:qualifiedCardinality 1 ],
        biolink:ChemicalToChemicalAssociation ;
    skos:definition """A causal relationship between two chemical entities, where the subject represents the upstream entity and the object represents the downstream. For any such association there is an implicit reaction:
  IF
  R has-input C1 AND
  R has-output C2 AND
  R enabled-by P AND
  R type Reaction
  THEN
  C1 derives-into C2 <<catalyst qualifier P>>""" .

biolink:ChemicalToDiseaseOrPhenotypicFeatureAssociation a owl:Class ;
    rdfs:label "chemical to disease or phenotypic feature association" ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:onClass biolink:DiseaseOrPhenotypicFeature ;
            owl:onProperty rdf:object ;
            owl:qualifiedCardinality 1 ],
        biolink:Association,
        biolink:ChemicalToEntityAssociationMixin,
        biolink:EntityToDiseaseOrPhenotypicFeatureAssociationMixin ;
    skos:definition "An interaction between a chemical entity and a phenotype or disease, where the presence of the chemical gives rise to or exacerbates the phenotype." ;
    skos:narrowMatch SIO:000993 .

biolink:ChemicalToPathwayAssociation a owl:Class ;
    rdfs:label "chemical to pathway association" ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:onClass biolink:ChemicalEntity ;
            owl:onProperty rdf:subject ;
            owl:qualifiedCardinality 1 ],
        [ a owl:Restriction ;
            owl:onClass biolink:Pathway ;
            owl:onProperty rdf:object ;
            owl:qualifiedCardinality 1 ],
        biolink:Association,
        biolink:ChemicalToEntityAssociationMixin ;
    skos:definition "An interaction between a chemical entity and a biological process or pathway." ;
    skos:exactMatch SIO:001250 .

biolink:ChiSquaredAnalysisResult a owl:Class ;
    rdfs:label "chi squared analysis result" ;
    rdfs:subClassOf biolink:StudyResult ;
    skos:definition "A result of a chi squared analysis." .

biolink:ClinicalFinding a owl:Class ;
    rdfs:label "clinical finding" ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:allValuesFrom biolink:ClinicalAttribute ;
            owl:onProperty biolink:has_attribute ],
        biolink:PhenotypicFeature ;
    skos:definition "this category is currently considered broad enough to tag clinical lab measurements and other biological attributes taken as 'clinical traits' with some statistical score, for example, a p value in genetic associations." .

biolink:ClinicalMeasurement a owl:Class ;
    rdfs:label "clinical measurement" ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:onClass biolink:OntologyClass ;
            owl:onProperty biolink:has_attribute_type ;
            owl:qualifiedCardinality 1 ],
        biolink:ClinicalAttribute ;
    skos:definition "A clinical measurement is a special kind of attribute which results from a laboratory observation from a subject individual or sample. Measurements can be connected to their subject by the 'has attribute' slot." ;
    skos:exactMatch EFO:0001444 .

biolink:ClinicalTrial a owl:Class ;
    rdfs:label "clinical trial" ;
    rdfs:subClassOf biolink:ClinicalEntity .

biolink:Cohort a owl:Class ;
    rdfs:label "cohort" ;
    rdfs:subClassOf biolink:StudyPopulation,
        biolink:SubjectOfInvestigation ;
    skos:definition "A group of people banded together or treated as a group who share common characteristics. A cohort 'study' is a particular form of longitudinal study that samples a cohort, performing a cross-section at intervals through time." ;
    skos:exactMatch WIKIDATA:Q1303415 ;
    skos:narrowMatch STY:T097,
        STY:T099,
        STY:T100,
        STY:T101 .

biolink:CommonDataElement a owl:Class ;
    rdfs:label "common data element" ;
    rdfs:subClassOf biolink:InformationContentEntity ;
    skos:closeMatch <http://purl.obolibrary.org/obo/NCIT_C19984> ;
    skos:definition "A Common Data Element (CDE) is a standardized, precisely defined question, paired with a set of allowable  responses, used systematically across different sites, studies, or clinical trials to ensure consistent  data collection. Multiple CDEs (from one or more Collections) can be curated into Forms.  (https://cde.nlm.nih.gov/home)" .

biolink:ComplexChemicalExposure a owl:Class ;
    rdfs:label "complex chemical exposure" ;
    rdfs:subClassOf biolink:Attribute ;
    skos:definition "A complex chemical exposure is an intake of a chemical mixture (e.g. gasoline), other than a drug." .

biolink:ComplexMolecularMixture a owl:Class ;
    rdfs:label "complex molecular mixture" ;
    rdfs:subClassOf biolink:ChemicalMixture ;
    skos:definition "A complex molecular mixture is a chemical mixture composed of two or more molecular entities with unknown concentration and stoichiometry." .

biolink:ConceptCountAnalysisResult a owl:Class ;
    rdfs:label "concept count analysis result" ;
    rdfs:subClassOf biolink:StudyResult ;
    skos:definition "A result of a concept count analysis." .

biolink:ContributorAssociation a owl:Class ;
    rdfs:label "contributor association" ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:onClass biolink:InformationContentEntity ;
            owl:onProperty rdf:subject ;
            owl:qualifiedCardinality 1 ],
        [ a owl:Restriction ;
            owl:onClass biolink:PredicateType ;
            owl:onProperty rdf:predicate ;
            owl:qualifiedCardinality 1 ],
        [ a owl:Restriction ;
            owl:onClass biolink:Agent ;
            owl:onProperty rdf:object ;
            owl:qualifiedCardinality 1 ],
        [ a owl:Restriction ;
            owl:allValuesFrom biolink:OntologyClass ;
            owl:onProperty biolink:qualifiers ],
        biolink:Association ;
    skos:definition "Any association between an entity (such as a publication) and various agents that contribute to its realisation" .

biolink:DiseaseOrPhenotypicFeatureExposure a owl:Class ;
    rdfs:label "disease or phenotypic feature exposure" ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:maxQualifiedCardinality 1 ;
            owl:onClass biolink:TimeType ;
            owl:onProperty biolink:timepoint ],
        biolink:Attribute,
        biolink:ExposureEvent,
        biolink:PathologicalEntityMixin ;
    skos:definition "A disease or phenotypic feature state, when viewed as an exposure, represents an precondition, leading to or influencing an outcome, e.g. HIV predisposing an individual to infections; a relative deficiency of skin pigmentation predisposing an individual to skin cancer." .

biolink:DiseaseOrPhenotypicFeatureOutcome a owl:Class ;
    rdfs:label "disease or phenotypic feature outcome" ;
    rdfs:subClassOf biolink:Outcome ;
    skos:definition "Physiological outcomes resulting from an exposure event which is the manifestation of a disease or other characteristic phenotype." .

biolink:DiseaseOrPhenotypicFeatureToGeneticInheritanceAssociation a owl:Class ;
    rdfs:label "disease or phenotypic feature to genetic inheritance association" ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:onClass biolink:PredicateType ;
            owl:onProperty rdf:predicate ;
            owl:qualifiedCardinality 1 ],
        [ a owl:Restriction ;
            owl:onClass biolink:GeneticInheritance ;
            owl:onProperty rdf:object ;
            owl:qualifiedCardinality 1 ],
        biolink:Association,
        biolink:DiseaseOrPhenotypicFeatureToEntityAssociationMixin ;
    skos:definition "An association between either a disease or a phenotypic feature and its mode of (genetic) inheritance." .

biolink:DiseaseOrPhenotypicFeatureToLocationAssociation a owl:Class ;
    rdfs:label "disease or phenotypic feature to location association" ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:onClass biolink:AnatomicalEntity ;
            owl:onProperty rdf:object ;
            owl:qualifiedCardinality 1 ],
        biolink:Association,
        biolink:DiseaseOrPhenotypicFeatureToEntityAssociationMixin ;
    skos:definition "An association between either a disease or a phenotypic feature and an anatomical entity, where the disease/feature manifests in that site." .

biolink:DiseaseToExposureEventAssociation a owl:Class ;
    rdfs:label "disease to exposure event association" ;
    rdfs:subClassOf biolink:Association,
        biolink:DiseaseToEntityAssociationMixin,
        biolink:EntityToExposureEventAssociationMixin ;
    skos:definition "An association between an exposure event and a disease." .

biolink:DiseaseToPhenotypicFeatureAssociation a owl:Class ;
    rdfs:label "disease to phenotypic feature association" ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:maxQualifiedCardinality 1 ;
            owl:onClass linkml:Integer ;
            owl:onProperty biolink:has_total ],
        [ a owl:Restriction ;
            owl:maxQualifiedCardinality 1 ;
            owl:onClass linkml:Integer ;
            owl:onProperty biolink:has_count ],
        [ a owl:Restriction ;
            owl:maxQualifiedCardinality 1 ;
            owl:onClass biolink:FrequencyValue ;
            owl:onProperty biolink:frequency_qualifier ],
        [ a owl:Restriction ;
            owl:onClass biolink:PhenotypicFeature ;
            owl:onProperty rdf:object ;
            owl:qualifiedCardinality 1 ],
        [ a owl:Restriction ;
            owl:maxQualifiedCardinality 1 ;
            owl:onClass linkml:Double ;
            owl:onProperty biolink:has_percentage ],
        [ a owl:Restriction ;
            owl:maxQualifiedCardinality 1 ;
            owl:onClass linkml:Double ;
            owl:onProperty biolink:has_quotient ],
        [ a owl:Restriction ;
            owl:onClass biolink:Disease ;
            owl:onProperty rdf:subject ;
            owl:qualifiedCardinality 1 ],
        [ a owl:Restriction ;
            owl:maxQualifiedCardinality 1 ;
            owl:onClass biolink:Onset ;
            owl:onProperty biolink:onset_qualifier ],
        [ a owl:Restriction ;
            owl:maxQualifiedCardinality 1 ;
            owl:onClass biolink:BiologicalSex ;
            owl:onProperty biolink:sex_qualifier ],
        [ a owl:Restriction ;
            owl:maxQualifiedCardinality 1 ;
            owl:onClass biolink:SeverityValue ;
            owl:onProperty biolink:severity_qualifier ],
        biolink:Association,
        biolink:DiseaseToEntityAssociationMixin,
        biolink:EntityToPhenotypicFeatureAssociationMixin ;
    skos:closeMatch dcid:DiseaseSymptomAssociation ;
    skos:definition "An association between a disease and a phenotypic feature in which the phenotypic feature is associated with the disease in some way." .

biolink:DrugToGeneAssociation a owl:Class ;
    rdfs:label "drug to gene association" ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:onClass biolink:GeneOrGeneProduct ;
            owl:onProperty rdf:object ;
            owl:qualifiedCardinality 1 ],
        biolink:Association,
        biolink:DrugToEntityAssociationMixin ;
    skos:definition "An interaction between a drug and a gene or gene product." ;
    skos:relatedMatch SIO:001257 .

biolink:DrugToGeneInteractionExposure a owl:Class ;
    rdfs:label "drug to gene interaction exposure" ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:allValuesFrom biolink:Gene ;
            owl:onProperty biolink:has_gene_or_gene_product ],
        biolink:DrugExposure,
        biolink:GeneGroupingMixin ;
    skos:definition "drug to gene interaction exposure is a drug exposure is where the interactions of the drug with specific genes are known to constitute an 'exposure' to the organism, leading to or influencing an outcome." .

biolink:DruggableGeneToDiseaseAssociation a owl:Class ;
    rdfs:label "druggable gene to disease association" ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:allValuesFrom biolink:DruggableGeneCategoryEnum ;
            owl:onProperty biolink:has_evidence ],
        [ a owl:Restriction ;
            owl:onClass biolink:GeneOrGeneProduct ;
            owl:onProperty rdf:subject ;
            owl:qualifiedCardinality 1 ],
        [ a owl:Restriction ;
            owl:onClass biolink:PredicateType ;
            owl:onProperty rdf:predicate ;
            owl:qualifiedCardinality 1 ],
        biolink:EntityToDiseaseAssociationMixin,
        biolink:GeneToDiseaseAssociation,
        biolink:GeneToEntityAssociationMixin .

biolink:EntityToDiseaseAssociation a owl:Class ;
    rdfs:label "entity to disease association" ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:maxQualifiedCardinality 1 ;
            owl:onClass biolink:FDAApprovalStatusEnum ;
            owl:onProperty biolink:FDA_approval_status ],
        biolink:Association .

biolink:EntityToPhenotypicFeatureAssociation a owl:Class ;
    rdfs:label "entity to phenotypic feature association" ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:maxQualifiedCardinality 1 ;
            owl:onClass biolink:FDAApprovalStatusEnum ;
            owl:onProperty biolink:FDA_approval_status ],
        biolink:Association .

biolink:EnvironmentalFeature a owl:Class ;
    rdfs:label "environmental feature" ;
    rdfs:subClassOf biolink:PlanetaryEntity ;
    skos:exactMatch <http://purl.obolibrary.org/obo/ENVO_01000254> .

biolink:EnvironmentalFoodContaminant a owl:Class ;
    rdfs:label "environmental food contaminant" ;
    rdfs:subClassOf biolink:ChemicalEntity ;
    skos:relatedMatch <http://purl.obolibrary.org/obo/CHEBI_78299> .

biolink:EnvironmentalProcess a owl:Class ;
    rdfs:label "environmental process" ;
    rdfs:subClassOf biolink:Occurrent,
        biolink:PlanetaryEntity ;
    skos:exactMatch <http://purl.obolibrary.org/obo/ENVO_02500000> .

biolink:EpidemiologicalOutcome a owl:Class ;
    rdfs:label "epidemiological outcome" ;
    rdfs:subClassOf biolink:Outcome ;
    skos:definition "An epidemiological outcome, such as societal disease burden, resulting from an exposure event." ;
    skos:relatedMatch <http://purl.obolibrary.org/obo/NCIT_C19291> .

biolink:Event a owl:Class ;
    rdfs:label "event" ;
    rdfs:subClassOf biolink:NamedThing ;
    skos:definition "Something that happens at a given place and time." ;
    skos:exactMatch STY:T051,
        <http://purl.obolibrary.org/obo/NCIT_C25499> .

biolink:ExonToTranscriptRelationship a owl:Class ;
    rdfs:label "exon to transcript relationship" ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:onClass biolink:Transcript ;
            owl:onProperty rdf:object ;
            owl:qualifiedCardinality 1 ],
        [ a owl:Restriction ;
            owl:onClass biolink:Exon ;
            owl:onProperty rdf:subject ;
            owl:qualifiedCardinality 1 ],
        biolink:SequenceFeatureRelationship ;
    skos:definition "A transcript is formed from multiple exons" .

biolink:ExposureEventToOutcomeAssociation a owl:Class ;
    rdfs:label "exposure event to outcome association" ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:maxQualifiedCardinality 1 ;
            owl:onClass biolink:TimeType ;
            owl:onProperty biolink:temporal_context_qualifier ],
        [ a owl:Restriction ;
            owl:maxQualifiedCardinality 1 ;
            owl:onClass biolink:PopulationOfIndividualOrganisms ;
            owl:onProperty biolink:population_context_qualifier ],
        biolink:Association,
        biolink:EntityToOutcomeAssociationMixin ;
    skos:definition "An association between an exposure event and an outcome." .

biolink:ExposureEventToPhenotypicFeatureAssociation a owl:Class ;
    rdfs:label "exposure event to phenotypic feature association" ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:maxQualifiedCardinality 1 ;
            owl:onClass linkml:Integer ;
            owl:onProperty biolink:has_total ],
        [ a owl:Restriction ;
            owl:maxQualifiedCardinality 1 ;
            owl:onClass biolink:FrequencyValue ;
            owl:onProperty biolink:frequency_qualifier ],
        [ a owl:Restriction ;
            owl:maxQualifiedCardinality 1 ;
            owl:onClass biolink:SeverityValue ;
            owl:onProperty biolink:severity_qualifier ],
        [ a owl:Restriction ;
            owl:onClass biolink:ExposureEvent ;
            owl:onProperty rdf:subject ;
            owl:qualifiedCardinality 1 ],
        [ a owl:Restriction ;
            owl:maxQualifiedCardinality 1 ;
            owl:onClass linkml:Integer ;
            owl:onProperty biolink:has_count ],
        [ a owl:Restriction ;
            owl:maxQualifiedCardinality 1 ;
            owl:onClass biolink:Onset ;
            owl:onProperty biolink:onset_qualifier ],
        [ a owl:Restriction ;
            owl:maxQualifiedCardinality 1 ;
            owl:onClass linkml:Double ;
            owl:onProperty biolink:has_quotient ],
        [ a owl:Restriction ;
            owl:maxQualifiedCardinality 1 ;
            owl:onClass linkml:Double ;
            owl:onProperty biolink:has_percentage ],
        [ a owl:Restriction ;
            owl:maxQualifiedCardinality 1 ;
            owl:onClass biolink:BiologicalSex ;
            owl:onProperty biolink:sex_qualifier ],
        biolink:Association,
        biolink:EntityToPhenotypicFeatureAssociationMixin ;
    skos:definition "Any association between an environment and a phenotypic feature, where being in the environment influences the phenotype." .

biolink:Food a owl:Class ;
    rdfs:label "food" ;
    rdfs:subClassOf biolink:ChemicalMixture ;
    skos:definition "A substance consumed by a living organism as a source of nutrition" ;
    skos:exactMatch STY:T168 .

biolink:FoodAdditive a owl:Class ;
    rdfs:label "food additive" ;
    rdfs:subClassOf biolink:ChemicalEntity ;
    skos:relatedMatch <http://purl.obolibrary.org/obo/CHEBI_64047> .

biolink:GeneAsAModelOfDiseaseAssociation a owl:Class ;
    rdfs:label "gene as a model of disease association" ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:onClass biolink:GeneOrGeneProduct ;
            owl:onProperty rdf:subject ;
            owl:qualifiedCardinality 1 ],
        biolink:EntityToDiseaseAssociationMixin,
        biolink:GeneToDiseaseAssociation,
        biolink:ModelToDiseaseAssociationMixin .

biolink:GeneHasVariantThatContributesToDiseaseAssociation a owl:Class ;
    rdfs:label "gene has variant that contributes to disease association" ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:maxQualifiedCardinality 1 ;
            owl:onClass linkml:String ;
            owl:onProperty biolink:subject_form_or_variant_qualifier ],
        [ a owl:Restriction ;
            owl:onClass biolink:Disease ;
            owl:onProperty rdf:object ;
            owl:qualifiedCardinality 1 ],
        [ a owl:Restriction ;
            owl:onClass biolink:PredicateType ;
            owl:onProperty rdf:predicate ;
            owl:qualifiedCardinality 1 ],
        [ a owl:Restriction ;
            owl:onClass biolink:GeneOrGeneProduct ;
            owl:onProperty rdf:subject ;
            owl:qualifiedCardinality 1 ],
        biolink:GeneToDiseaseAssociation .

biolink:GeneOrGeneProductOrChemicalEntityAspectEnum a owl:Class ;
    rdfs:label "GeneOrGeneProductOrChemicalEntityAspectEnum" ;
    owl:unionOf ( <https://w3id.org/biolink/vocab/GeneOrGeneProductOrChemicalEntityAspectEnum#activity_or_abundance> <https://w3id.org/biolink/vocab/GeneOrGeneProductOrChemicalEntityAspectEnum#abundance> <https://w3id.org/biolink/vocab/GeneOrGeneProductOrChemicalEntityAspectEnum#activity> <https://w3id.org/biolink/vocab/GeneOrGeneProductOrChemicalEntityAspectEnum#expression> <https://w3id.org/biolink/vocab/GeneOrGeneProductOrChemicalEntityAspectEnum#synthesis> <https://w3id.org/biolink/vocab/GeneOrGeneProductOrChemicalEntityAspectEnum#degradation> <https://w3id.org/biolink/vocab/GeneOrGeneProductOrChemicalEntityAspectEnum#cleavage> <https://w3id.org/biolink/vocab/GeneOrGeneProductOrChemicalEntityAspectEnum#hydrolysis> <https://w3id.org/biolink/vocab/GeneOrGeneProductOrChemicalEntityAspectEnum#metabolic_processing> <https://w3id.org/biolink/vocab/GeneOrGeneProductOrChemicalEntityAspectEnum#mutation_rate> <https://w3id.org/biolink/vocab/GeneOrGeneProductOrChemicalEntityAspectEnum#stability> <https://w3id.org/biolink/vocab/GeneOrGeneProductOrChemicalEntityAspectEnum#folding> <https://w3id.org/biolink/vocab/GeneOrGeneProductOrChemicalEntityAspectEnum#localization> <https://w3id.org/biolink/vocab/GeneOrGeneProductOrChemicalEntityAspectEnum#transport> <https://w3id.org/biolink/vocab/GeneOrGeneProductOrChemicalEntityAspectEnum#secretion> <https://w3id.org/biolink/vocab/GeneOrGeneProductOrChemicalEntityAspectEnum#uptake> <https://w3id.org/biolink/vocab/GeneOrGeneProductOrChemicalEntityAspectEnum#molecular_modification> <https://w3id.org/biolink/vocab/GeneOrGeneProductOrChemicalEntityAspectEnum#acetylation> <https://w3id.org/biolink/vocab/GeneOrGeneProductOrChemicalEntityAspectEnum#acylation> <https://w3id.org/biolink/vocab/GeneOrGeneProductOrChemicalEntityAspectEnum#alkylation> <https://w3id.org/biolink/vocab/GeneOrGeneProductOrChemicalEntityAspectEnum#amination> <https://w3id.org/biolink/vocab/GeneOrGeneProductOrChemicalEntityAspectEnum#carbamoylation> <https://w3id.org/biolink/vocab/GeneOrGeneProductOrChemicalEntityAspectEnum#ethylation> <https://w3id.org/biolink/vocab/GeneOrGeneProductOrChemicalEntityAspectEnum#glutathionylation> <https://w3id.org/biolink/vocab/GeneOrGeneProductOrChemicalEntityAspectEnum#glycation> <https://w3id.org/biolink/vocab/GeneOrGeneProductOrChemicalEntityAspectEnum#glycosylation> <https://w3id.org/biolink/vocab/GeneOrGeneProductOrChemicalEntityAspectEnum#glucuronidation> <https://w3id.org/biolink/vocab/GeneOrGeneProductOrChemicalEntityAspectEnum#n_linked_glycosylation> <https://w3id.org/biolink/vocab/GeneOrGeneProductOrChemicalEntityAspectEnum#o_linked_glycosylation> <https://w3id.org/biolink/vocab/GeneOrGeneProductOrChemicalEntityAspectEnum#hydroxylation> <https://w3id.org/biolink/vocab/GeneOrGeneProductOrChemicalEntityAspectEnum#lipidation> <https://w3id.org/biolink/vocab/GeneOrGeneProductOrChemicalEntityAspectEnum#farnesylation> <https://w3id.org/biolink/vocab/GeneOrGeneProductOrChemicalEntityAspectEnum#geranoylation> <https://w3id.org/biolink/vocab/GeneOrGeneProductOrChemicalEntityAspectEnum#myristoylation> <https://w3id.org/biolink/vocab/GeneOrGeneProductOrChemicalEntityAspectEnum#palmitoylation> <https://w3id.org/biolink/vocab/GeneOrGeneProductOrChemicalEntityAspectEnum#prenylation> <https://w3id.org/biolink/vocab/GeneOrGeneProductOrChemicalEntityAspectEnum#methylation> <https://w3id.org/biolink/vocab/GeneOrGeneProductOrChemicalEntityAspectEnum#nitrosation> <https://w3id.org/biolink/vocab/GeneOrGeneProductOrChemicalEntityAspectEnum#nucleotidylation> <https://w3id.org/biolink/vocab/GeneOrGeneProductOrChemicalEntityAspectEnum#phosphorylation> <https://w3id.org/biolink/vocab/GeneOrGeneProductOrChemicalEntityAspectEnum#ribosylation> <https://w3id.org/biolink/vocab/GeneOrGeneProductOrChemicalEntityAspectEnum#ADP-ribosylation> <https://w3id.org/biolink/vocab/GeneOrGeneProductOrChemicalEntityAspectEnum#sulfation> <https://w3id.org/biolink/vocab/GeneOrGeneProductOrChemicalEntityAspectEnum#sumoylation> <https://w3id.org/biolink/vocab/GeneOrGeneProductOrChemicalEntityAspectEnum#ubiquitination> <https://w3id.org/biolink/vocab/GeneOrGeneProductOrChemicalEntityAspectEnum#oxidation> <https://w3id.org/biolink/vocab/GeneOrGeneProductOrChemicalEntityAspectEnum#reduction> <https://w3id.org/biolink/vocab/GeneOrGeneProductOrChemicalEntityAspectEnum#carboxylation> ) ;
    linkml:permissible_values <https://w3id.org/biolink/vocab/GeneOrGeneProductOrChemicalEntityAspectEnum#ADP-ribosylation>,
        <https://w3id.org/biolink/vocab/GeneOrGeneProductOrChemicalEntityAspectEnum#abundance>,
        <https://w3id.org/biolink/vocab/GeneOrGeneProductOrChemicalEntityAspectEnum#acetylation>,
        <https://w3id.org/biolink/vocab/GeneOrGeneProductOrChemicalEntityAspectEnum#activity>,
        <https://w3id.org/biolink/vocab/GeneOrGeneProductOrChemicalEntityAspectEnum#activity_or_abundance>,
        <https://w3id.org/biolink/vocab/GeneOrGeneProductOrChemicalEntityAspectEnum#acylation>,
        <https://w3id.org/biolink/vocab/GeneOrGeneProductOrChemicalEntityAspectEnum#alkylation>,
        <https://w3id.org/biolink/vocab/GeneOrGeneProductOrChemicalEntityAspectEnum#amination>,
        <https://w3id.org/biolink/vocab/GeneOrGeneProductOrChemicalEntityAspectEnum#carbamoylation>,
        <https://w3id.org/biolink/vocab/GeneOrGeneProductOrChemicalEntityAspectEnum#carboxylation>,
        <https://w3id.org/biolink/vocab/GeneOrGeneProductOrChemicalEntityAspectEnum#cleavage>,
        <https://w3id.org/biolink/vocab/GeneOrGeneProductOrChemicalEntityAspectEnum#degradation>,
        <https://w3id.org/biolink/vocab/GeneOrGeneProductOrChemicalEntityAspectEnum#ethylation>,
        <https://w3id.org/biolink/vocab/GeneOrGeneProductOrChemicalEntityAspectEnum#expression>,
        <https://w3id.org/biolink/vocab/GeneOrGeneProductOrChemicalEntityAspectEnum#farnesylation>,
        <https://w3id.org/biolink/vocab/GeneOrGeneProductOrChemicalEntityAspectEnum#folding>,
        <https://w3id.org/biolink/vocab/GeneOrGeneProductOrChemicalEntityAspectEnum#geranoylation>,
        <https://w3id.org/biolink/vocab/GeneOrGeneProductOrChemicalEntityAspectEnum#glucuronidation>,
        <https://w3id.org/biolink/vocab/GeneOrGeneProductOrChemicalEntityAspectEnum#glutathionylation>,
        <https://w3id.org/biolink/vocab/GeneOrGeneProductOrChemicalEntityAspectEnum#glycation>,
        <https://w3id.org/biolink/vocab/GeneOrGeneProductOrChemicalEntityAspectEnum#glycosylation>,
        <https://w3id.org/biolink/vocab/GeneOrGeneProductOrChemicalEntityAspectEnum#hydrolysis>,
        <https://w3id.org/biolink/vocab/GeneOrGeneProductOrChemicalEntityAspectEnum#hydroxylation>,
        <https://w3id.org/biolink/vocab/GeneOrGeneProductOrChemicalEntityAspectEnum#lipidation>,
        <https://w3id.org/biolink/vocab/GeneOrGeneProductOrChemicalEntityAspectEnum#localization>,
        <https://w3id.org/biolink/vocab/GeneOrGeneProductOrChemicalEntityAspectEnum#metabolic_processing>,
        <https://w3id.org/biolink/vocab/GeneOrGeneProductOrChemicalEntityAspectEnum#methylation>,
        <https://w3id.org/biolink/vocab/GeneOrGeneProductOrChemicalEntityAspectEnum#molecular_modification>,
        <https://w3id.org/biolink/vocab/GeneOrGeneProductOrChemicalEntityAspectEnum#mutation_rate>,
        <https://w3id.org/biolink/vocab/GeneOrGeneProductOrChemicalEntityAspectEnum#myristoylation>,
        <https://w3id.org/biolink/vocab/GeneOrGeneProductOrChemicalEntityAspectEnum#n_linked_glycosylation>,
        <https://w3id.org/biolink/vocab/GeneOrGeneProductOrChemicalEntityAspectEnum#nitrosation>,
        <https://w3id.org/biolink/vocab/GeneOrGeneProductOrChemicalEntityAspectEnum#nucleotidylation>,
        <https://w3id.org/biolink/vocab/GeneOrGeneProductOrChemicalEntityAspectEnum#o_linked_glycosylation>,
        <https://w3id.org/biolink/vocab/GeneOrGeneProductOrChemicalEntityAspectEnum#oxidation>,
        <https://w3id.org/biolink/vocab/GeneOrGeneProductOrChemicalEntityAspectEnum#palmitoylation>,
        <https://w3id.org/biolink/vocab/GeneOrGeneProductOrChemicalEntityAspectEnum#phosphorylation>,
        <https://w3id.org/biolink/vocab/GeneOrGeneProductOrChemicalEntityAspectEnum#prenylation>,
        <https://w3id.org/biolink/vocab/GeneOrGeneProductOrChemicalEntityAspectEnum#reduction>,
        <https://w3id.org/biolink/vocab/GeneOrGeneProductOrChemicalEntityAspectEnum#ribosylation>,
        <https://w3id.org/biolink/vocab/GeneOrGeneProductOrChemicalEntityAspectEnum#secretion>,
        <https://w3id.org/biolink/vocab/GeneOrGeneProductOrChemicalEntityAspectEnum#stability>,
        <https://w3id.org/biolink/vocab/GeneOrGeneProductOrChemicalEntityAspectEnum#sulfation>,
        <https://w3id.org/biolink/vocab/GeneOrGeneProductOrChemicalEntityAspectEnum#sumoylation>,
        <https://w3id.org/biolink/vocab/GeneOrGeneProductOrChemicalEntityAspectEnum#synthesis>,
        <https://w3id.org/biolink/vocab/GeneOrGeneProductOrChemicalEntityAspectEnum#transport>,
        <https://w3id.org/biolink/vocab/GeneOrGeneProductOrChemicalEntityAspectEnum#ubiquitination>,
        <https://w3id.org/biolink/vocab/GeneOrGeneProductOrChemicalEntityAspectEnum#uptake> .

biolink:GeneToExpressionSiteAssociation a owl:Class ;
    rdfs:label "gene to expression site association" ;
    rdfs:seeAlso "https://github.com/monarch-initiative/ingest-artifacts/tree/master/sources/BGee" ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:onClass biolink:GeneOrGeneProduct ;
            owl:onProperty rdf:subject ;
            owl:qualifiedCardinality 1 ],
        [ a owl:Restriction ;
            owl:maxQualifiedCardinality 1 ;
            owl:onClass biolink:OntologyClass ;
            owl:onProperty biolink:quantifier_qualifier ],
        [ a owl:Restriction ;
            owl:onClass biolink:PredicateType ;
            owl:onProperty rdf:predicate ;
            owl:qualifiedCardinality 1 ],
        [ a owl:Restriction ;
            owl:onClass biolink:AnatomicalEntity ;
            owl:onProperty rdf:object ;
            owl:qualifiedCardinality 1 ],
        [ a owl:Restriction ;
            owl:maxQualifiedCardinality 1 ;
            owl:onClass biolink:LifeStage ;
            owl:onProperty biolink:stage_qualifier ],
        biolink:Association ;
    skos:definition "An association between a gene and a gene expression site, possibly qualified by stage/timing info." ;
    skos:editorialNote "TBD: introduce subclasses for distinction between wild-type and experimental conditions?" .

biolink:GeneToGeneCoexpressionAssociation a owl:Class ;
    rdfs:label "gene to gene coexpression association" ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:onClass biolink:PredicateType ;
            owl:onProperty rdf:predicate ;
            owl:qualifiedCardinality 1 ],
        [ a owl:Restriction ;
            owl:maxQualifiedCardinality 1 ;
            owl:onClass biolink:LifeStage ;
            owl:onProperty biolink:stage_qualifier ],
        [ a owl:Restriction ;
            owl:maxQualifiedCardinality 1 ;
            owl:onClass biolink:AnatomicalEntity ;
            owl:onProperty biolink:expression_site ],
        [ a owl:Restriction ;
            owl:maxQualifiedCardinality 1 ;
            owl:onClass biolink:DiseaseOrPhenotypicFeature ;
            owl:onProperty biolink:phenotypic_state ],
        [ a owl:Restriction ;
            owl:maxQualifiedCardinality 1 ;
            owl:onClass biolink:OntologyClass ;
            owl:onProperty biolink:quantifier_qualifier ],
        biolink:GeneExpressionMixin,
        biolink:GeneToGeneAssociation ;
    skos:definition "Indicates that two genes are co-expressed, generally under the same conditions." .

biolink:GeneToGeneFamilyAssociation a owl:Class ;
    rdfs:label "gene to gene family association" ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:onClass biolink:PredicateType ;
            owl:onProperty rdf:predicate ;
            owl:qualifiedCardinality 1 ],
        [ a owl:Restriction ;
            owl:onClass biolink:GeneFamily ;
            owl:onProperty rdf:object ;
            owl:qualifiedCardinality 1 ],
        [ a owl:Restriction ;
            owl:onClass biolink:Gene ;
            owl:onProperty rdf:subject ;
            owl:qualifiedCardinality 1 ],
        biolink:Association ;
    skos:definition "Set membership of a gene in a family of genes related by common evolutionary ancestry usually inferred by sequence comparisons. The genes in a given family generally share common sequence motifs which generally map onto shared gene product structure-function relationships." .

biolink:GeneToGeneHomologyAssociation a owl:Class ;
    rdfs:label "gene to gene homology association" ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:onClass biolink:GeneOrGeneProduct ;
            owl:onProperty rdf:subject ;
            owl:qualifiedCardinality 1 ],
        [ a owl:Restriction ;
            owl:onClass biolink:PredicateType ;
            owl:onProperty rdf:predicate ;
            owl:qualifiedCardinality 1 ],
        [ a owl:Restriction ;
            owl:onClass biolink:GeneOrGeneProduct ;
            owl:onProperty rdf:object ;
            owl:qualifiedCardinality 1 ],
        biolink:GeneToGeneAssociation ;
    skos:definition "A homology association between two genes. May be orthology (in which case the species of subject and object should differ) or paralogy (in which case the species may be the same)" .

biolink:GeneToGeneProductRelationship a owl:Class ;
    rdfs:label "gene to gene product relationship" ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:onClass biolink:GeneProductMixin ;
            owl:onProperty rdf:object ;
            owl:qualifiedCardinality 1 ],
        [ a owl:Restriction ;
            owl:onClass biolink:PredicateType ;
            owl:onProperty rdf:predicate ;
            owl:qualifiedCardinality 1 ],
        [ a owl:Restriction ;
            owl:onClass biolink:Gene ;
            owl:onProperty rdf:subject ;
            owl:qualifiedCardinality 1 ],
        biolink:SequenceFeatureRelationship ;
    skos:definition "A gene is transcribed and potentially translated to a gene product" .

biolink:GeneToGoTermAssociation a owl:Class ;
    rdfs:label "gene to go term association" ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:onClass biolink:OntologyClass ;
            owl:onProperty rdf:object ;
            owl:qualifiedCardinality 1 ],
        [ a owl:Restriction ;
            owl:onClass biolink:Gene ;
            owl:onProperty rdf:subject ;
            owl:qualifiedCardinality 1 ],
        biolink:FunctionalAssociation ;
    skos:altLabel "functional association" ;
    skos:exactMatch WBVocab:Gene-GO-Association .

biolink:GeneToPathwayAssociation a owl:Class ;
    rdfs:label "gene to pathway association" ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:onClass biolink:GeneOrGeneProduct ;
            owl:onProperty rdf:subject ;
            owl:qualifiedCardinality 1 ],
        [ a owl:Restriction ;
            owl:onClass biolink:Pathway ;
            owl:onProperty rdf:object ;
            owl:qualifiedCardinality 1 ],
        biolink:Association,
        biolink:GeneToEntityAssociationMixin ;
    skos:definition "An interaction between a gene or gene product and a biological process or pathway." .

biolink:GeneToPhenotypicFeatureAssociation a owl:Class ;
    rdfs:label "gene to phenotypic feature association" ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:onClass biolink:GeneOrGeneProduct ;
            owl:onProperty rdf:subject ;
            owl:qualifiedCardinality 1 ],
        [ a owl:Restriction ;
            owl:maxQualifiedCardinality 1 ;
            owl:onClass biolink:SeverityValue ;
            owl:onProperty biolink:severity_qualifier ],
        [ a owl:Restriction ;
            owl:maxQualifiedCardinality 1 ;
            owl:onClass linkml:Double ;
            owl:onProperty biolink:has_percentage ],
        [ a owl:Restriction ;
            owl:maxQualifiedCardinality 1 ;
            owl:onClass biolink:FrequencyValue ;
            owl:onProperty biolink:frequency_qualifier ],
        [ a owl:Restriction ;
            owl:maxQualifiedCardinality 1 ;
            owl:onClass biolink:Onset ;
            owl:onProperty biolink:onset_qualifier ],
        [ a owl:Restriction ;
            owl:maxQualifiedCardinality 1 ;
            owl:onClass linkml:Double ;
            owl:onProperty biolink:has_quotient ],
        [ a owl:Restriction ;
            owl:onClass biolink:PhenotypicFeature ;
            owl:onProperty rdf:object ;
            owl:qualifiedCardinality 1 ],
        [ a owl:Restriction ;
            owl:maxQualifiedCardinality 1 ;
            owl:onClass biolink:BiologicalSex ;
            owl:onProperty biolink:sex_qualifier ],
        [ a owl:Restriction ;
            owl:maxQualifiedCardinality 1 ;
            owl:onClass linkml:Integer ;
            owl:onProperty biolink:has_total ],
        [ a owl:Restriction ;
            owl:maxQualifiedCardinality 1 ;
            owl:onClass linkml:Integer ;
            owl:onProperty biolink:has_count ],
        biolink:Association,
        biolink:EntityToPhenotypicFeatureAssociationMixin,
        biolink:GeneToEntityAssociationMixin ;
    skos:exactMatch WBVocab:Gene-Phenotype-Association .

biolink:Genome a owl:Class ;
    rdfs:label "genome" ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:maxQualifiedCardinality 1 ;
            owl:onClass biolink:BiologicalSequence ;
            owl:onProperty biolink:has_biological_sequence ],
        biolink:BiologicalEntity,
        biolink:GenomicEntity,
        biolink:OntologyClass,
        biolink:PhysicalEssence ;
    skos:closeMatch dcid:GenomeAssemblyUnit ;
    skos:definition "A genome is the sum of genetic material within a cell or virion." ;
    skos:exactMatch <http://purl.obolibrary.org/obo/SO_0001026>,
        SIO:000984,
        WIKIDATA:Q7020 .

biolink:GenomicBackgroundExposure a owl:Class ;
    rdfs:label "genomic background exposure" ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:allValuesFrom biolink:OrganismTaxon ;
            owl:onProperty biolink:in_taxon ],
        [ a owl:Restriction ;
            owl:allValuesFrom biolink:Gene ;
            owl:onProperty biolink:has_gene_or_gene_product ],
        [ a owl:Restriction ;
            owl:maxQualifiedCardinality 1 ;
            owl:onClass biolink:TimeType ;
            owl:onProperty biolink:timepoint ],
        [ a owl:Restriction ;
            owl:maxQualifiedCardinality 1 ;
            owl:onClass biolink:BiologicalSequence ;
            owl:onProperty biolink:has_biological_sequence ],
        biolink:Attribute,
        biolink:ExposureEvent,
        biolink:GeneGroupingMixin,
        biolink:GenomicEntity,
        biolink:OntologyClass,
        biolink:PhysicalEssence,
        biolink:ThingWithTaxon ;
    skos:definition "A genomic background exposure is where an individual's specific genomic background of genes, sequence variants or other pre-existing genomic conditions constitute a kind of 'exposure' to the organism, leading to or influencing an outcome." .

biolink:GenotypeAsAModelOfDiseaseAssociation a owl:Class ;
    rdfs:label "genotype as a model of disease association" ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:onClass biolink:Genotype ;
            owl:onProperty rdf:subject ;
            owl:qualifiedCardinality 1 ],
        biolink:EntityToDiseaseAssociationMixin,
        biolink:GenotypeToDiseaseAssociation,
        biolink:ModelToDiseaseAssociationMixin .

biolink:GenotypeToGeneAssociation a owl:Class ;
    rdfs:label "genotype to gene association" ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:onClass biolink:PredicateType ;
            owl:onProperty rdf:predicate ;
            owl:qualifiedCardinality 1 ],
        [ a owl:Restriction ;
            owl:onClass biolink:Gene ;
            owl:onProperty rdf:object ;
            owl:qualifiedCardinality 1 ],
        [ a owl:Restriction ;
            owl:onClass biolink:Genotype ;
            owl:onProperty rdf:subject ;
            owl:qualifiedCardinality 1 ],
        biolink:Association ;
    skos:definition "Any association between a genotype and a gene. The genotype have have multiple variants in that gene or a single one. There is no assumption of cardinality" .

biolink:GenotypeToGenotypePartAssociation a owl:Class ;
    rdfs:label "genotype to genotype part association" ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:onClass biolink:Genotype ;
            owl:onProperty rdf:object ;
            owl:qualifiedCardinality 1 ],
        [ a owl:Restriction ;
            owl:onClass biolink:Genotype ;
            owl:onProperty rdf:subject ;
            owl:qualifiedCardinality 1 ],
        [ a owl:Restriction ;
            owl:onClass biolink:PredicateType ;
            owl:onProperty rdf:predicate ;
            owl:qualifiedCardinality 1 ],
        biolink:Association ;
    skos:definition "Any association between one genotype and a genotypic entity that is a sub-component of it" .

biolink:GenotypeToPhenotypicFeatureAssociation a owl:Class ;
    rdfs:label "genotype to phenotypic feature association" ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:maxQualifiedCardinality 1 ;
            owl:onClass linkml:Double ;
            owl:onProperty biolink:has_quotient ],
        [ a owl:Restriction ;
            owl:maxQualifiedCardinality 1 ;
            owl:onClass linkml:Integer ;
            owl:onProperty biolink:has_count ],
        [ a owl:Restriction ;
            owl:maxQualifiedCardinality 1 ;
            owl:onClass linkml:Double ;
            owl:onProperty biolink:has_percentage ],
        [ a owl:Restriction ;
            owl:maxQualifiedCardinality 1 ;
            owl:onClass biolink:SeverityValue ;
            owl:onProperty biolink:severity_qualifier ],
        [ a owl:Restriction ;
            owl:maxQualifiedCardinality 1 ;
            owl:onClass biolink:Onset ;
            owl:onProperty biolink:onset_qualifier ],
        [ a owl:Restriction ;
            owl:onClass biolink:PredicateType ;
            owl:onProperty rdf:predicate ;
            owl:qualifiedCardinality 1 ],
        [ a owl:Restriction ;
            owl:maxQualifiedCardinality 1 ;
            owl:onClass biolink:FrequencyValue ;
            owl:onProperty biolink:frequency_qualifier ],
        [ a owl:Restriction ;
            owl:maxQualifiedCardinality 1 ;
            owl:onClass biolink:BiologicalSex ;
            owl:onProperty biolink:sex_qualifier ],
        [ a owl:Restriction ;
            owl:onClass biolink:Genotype ;
            owl:onProperty rdf:subject ;
            owl:qualifiedCardinality 1 ],
        [ a owl:Restriction ;
            owl:maxQualifiedCardinality 1 ;
            owl:onClass linkml:Integer ;
            owl:onProperty biolink:has_total ],
        biolink:Association,
        biolink:EntityToPhenotypicFeatureAssociationMixin,
        biolink:GenotypeToEntityAssociationMixin ;
    skos:definition "Any association between one genotype and a phenotypic feature, where having the genotype confers the phenotype, either in isolation or through environment" .

biolink:GenotypeToVariantAssociation a owl:Class ;
    rdfs:label "genotype to variant association" ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:onClass biolink:SequenceVariant ;
            owl:onProperty rdf:object ;
            owl:qualifiedCardinality 1 ],
        [ a owl:Restriction ;
            owl:onClass biolink:Genotype ;
            owl:onProperty rdf:subject ;
            owl:qualifiedCardinality 1 ],
        [ a owl:Restriction ;
            owl:onClass biolink:PredicateType ;
            owl:onProperty rdf:predicate ;
            owl:qualifiedCardinality 1 ],
        biolink:Association ;
    skos:definition "Any association between a genotype and a sequence variant." .

biolink:GenotypicSex a owl:Class ;
    rdfs:label "genotypic sex" ;
    rdfs:subClassOf biolink:BiologicalSex ;
    skos:definition "An attribute corresponding to the genotypic sex of the individual, based upon genotypic composition of sex chromosomes." ;
    skos:exactMatch <http://purl.obolibrary.org/obo/PATO_0020000> .

biolink:GeographicExposure a owl:Class ;
    rdfs:label "geographic exposure" ;
    rdfs:subClassOf biolink:EnvironmentalExposure,
        biolink:ExposureEvent ;
    skos:closeMatch dcid:GeologicalEvent ;
    skos:definition "A geographic exposure is a factor relating to geographic proximity to some impactful entity." ;
    skos:narrowMatch dcid:IceStoremEvent,
        dcid:LakeEffectSnowEvent,
        dcid:LandslideEvent,
        dcid:MarineDenseFogEvent,
        dcid:MarineLighteningEvent,
        dcid:MarineStrongWindEvent,
        dcid:MarineThunderstormWindEvent,
        dcid:StormEvent,
        dcid:StormSurgeTideEvent,
        dcid:StrongWindEvent,
        dcid:ThunderstormWindEvent,
        dcid:TornadoEvent,
        dcid:TropicalDepressionEvent,
        dcid:WinterStoremEvent .

biolink:GeographicLocationAtTime a owl:Class ;
    rdfs:label "geographic location at time" ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:maxQualifiedCardinality 1 ;
            owl:onClass biolink:TimeType ;
            owl:onProperty biolink:timepoint ],
        biolink:GeographicLocation ;
    skos:definition "a location that can be described in lat/long coordinates, for a particular time" .

biolink:GrossAnatomicalStructure a owl:Class ;
    rdfs:label "gross anatomical structure" ;
    rdfs:subClassOf biolink:AnatomicalEntity ;
    skos:altLabel "organ",
        "tissue" ;
    skos:exactMatch <http://purl.obolibrary.org/obo/UBERON_0010000>,
        WIKIDATA:Q4936952 ;
    skos:narrowMatch STY:T018,
        STY:T023,
        STY:T024 .

biolink:Haplotype a owl:Class ;
    rdfs:label "haplotype" ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:maxQualifiedCardinality 1 ;
            owl:onClass biolink:BiologicalSequence ;
            owl:onProperty biolink:has_biological_sequence ],
        biolink:BiologicalEntity,
        biolink:GenomicEntity,
        biolink:OntologyClass,
        biolink:PhysicalEssence ;
    skos:definition "A set of zero or more Alleles on a single instance of a Sequence[VMC]" ;
    skos:exactMatch <http://purl.obolibrary.org/obo/GENO_0000871>,
        <http://purl.obolibrary.org/obo/SO_0001024>,
        VMC:Haplotype .

biolink:Hospitalization a owl:Class ;
    rdfs:label "hospitalization" ;
    rdfs:subClassOf biolink:ClinicalIntervention ;
    skos:exactMatch SNOMEDCT:32485007,
        WIKIDATA:Q3140971 .

biolink:HospitalizationOutcome a owl:Class ;
    rdfs:label "hospitalization outcome" ;
    rdfs:subClassOf biolink:Outcome ;
    skos:definition "An outcome resulting from an exposure event which is the increased manifestation of acute (e.g. emergency room visit) or chronic (inpatient) hospitalization." .

biolink:InformationContentEntityToNamedThingAssociation a owl:Class ;
    rdfs:label "information content entity to named thing association" ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:onClass biolink:NamedThing ;
            owl:onProperty rdf:subject ;
            owl:qualifiedCardinality 1 ],
        [ a owl:Restriction ;
            owl:onClass biolink:PredicateType ;
            owl:onProperty rdf:predicate ;
            owl:qualifiedCardinality 1 ],
        [ a owl:Restriction ;
            owl:onClass biolink:NamedThing ;
            owl:onProperty rdf:object ;
            owl:qualifiedCardinality 1 ],
        biolink:Association ;
    skos:definition "association between a named thing and a information content entity where the specific context of the relationship between that named thing and the publication is unknown. For example, model organisms databases often capture the knowledge that a gene is found in a journal article, but not specifically the context in which that gene was documented in the article. In these cases, this association with the accompanying predicate 'mentions' could be used. Conversely, for more specific associations (like 'gene to disease association', the publication should be captured as an edge property)." .

biolink:MacromolecularComplex a owl:Class ;
    rdfs:label "macromolecular complex" ;
    rdfs:subClassOf biolink:BiologicalEntity,
        biolink:MacromolecularMachineMixin ;
    skos:definition "A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together." ;
    skos:exactMatch <http://purl.obolibrary.org/obo/GO_0032991>,
        WIKIDATA:Q22325163 .

biolink:MacromolecularMachineToBiologicalProcessAssociation a owl:Class ;
    rdfs:label "macromolecular machine to biological process association" ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:onClass biolink:BiologicalProcess ;
            owl:onProperty rdf:object ;
            owl:qualifiedCardinality 1 ],
        biolink:FunctionalAssociation,
        biolink:MacromolecularMachineToEntityAssociationMixin ;
    skos:definition "A functional association between a macromolecular machine (gene, gene product or complex) and a biological process or pathway (as represented in the GO biological process branch), where the entity carries out some part of the process, regulates it, or acts upstream of it." .

biolink:MacromolecularMachineToCellularComponentAssociation a owl:Class ;
    rdfs:label "macromolecular machine to cellular component association" ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:onClass biolink:CellularComponent ;
            owl:onProperty rdf:object ;
            owl:qualifiedCardinality 1 ],
        biolink:FunctionalAssociation,
        biolink:MacromolecularMachineToEntityAssociationMixin ;
    skos:definition "A functional association between a macromolecular machine (gene, gene product or complex) and a cellular component (as represented in the GO cellular component branch), where the entity carries out its function in the cellular component." .

biolink:MacromolecularMachineToMolecularActivityAssociation a owl:Class ;
    rdfs:label "macromolecular machine to molecular activity association" ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:onClass biolink:MolecularActivity ;
            owl:onProperty rdf:object ;
            owl:qualifiedCardinality 1 ],
        biolink:FunctionalAssociation,
        biolink:MacromolecularMachineToEntityAssociationMixin ;
    skos:definition "A functional association between a macromolecular machine (gene, gene product or complex) and a molecular activity (as represented in the GO molecular function branch), where the entity carries out the activity, or contributes to its execution." .

biolink:MaterialSampleDerivationAssociation a owl:Class ;
    rdfs:label "material sample derivation association" ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:onClass biolink:NamedThing ;
            owl:onProperty rdf:object ;
            owl:qualifiedCardinality 1 ],
        [ a owl:Restriction ;
            owl:onClass biolink:PredicateType ;
            owl:onProperty rdf:predicate ;
            owl:qualifiedCardinality 1 ],
        [ a owl:Restriction ;
            owl:onClass biolink:MaterialSample ;
            owl:onProperty rdf:subject ;
            owl:qualifiedCardinality 1 ],
        biolink:Association ;
    skos:definition "An association between a material sample and the material entity from which it is derived." .

biolink:MaterialSampleToDiseaseOrPhenotypicFeatureAssociation a owl:Class ;
    rdfs:label "material sample to disease or phenotypic feature association" ;
    rdfs:subClassOf biolink:Association,
        biolink:EntityToDiseaseOrPhenotypicFeatureAssociationMixin,
        biolink:MaterialSampleToEntityAssociationMixin ;
    skos:definition "An association between a material sample and a disease or phenotype." .

biolink:MicroRNA a owl:Class ;
    rdfs:label "microRNA" ;
    rdfs:subClassOf biolink:NoncodingRNAProduct ;
    skos:exactMatch <http://purl.obolibrary.org/obo/SO_0000276>,
        SIO:001397,
        WIKIDATA:Q310899 .

biolink:MolecularActivityToChemicalEntityAssociation a owl:Class ;
    rdfs:label "molecular activity to chemical entity association" ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:onClass biolink:ChemicalEntity ;
            owl:onProperty rdf:object ;
            owl:qualifiedCardinality 1 ],
        [ a owl:Restriction ;
            owl:onClass biolink:MolecularActivity ;
            owl:onProperty rdf:subject ;
            owl:qualifiedCardinality 1 ],
        biolink:Association ;
    skos:definition "Added in response to capturing relationship between microbiome activities as measured via measurements of blood analytes as collected via blood and stool samples" .

biolink:MolecularActivityToMolecularActivityAssociation a owl:Class ;
    rdfs:label "molecular activity to molecular activity association" ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:onClass biolink:MolecularActivity ;
            owl:onProperty rdf:subject ;
            owl:qualifiedCardinality 1 ],
        [ a owl:Restriction ;
            owl:onClass biolink:MolecularActivity ;
            owl:onProperty rdf:object ;
            owl:qualifiedCardinality 1 ],
        biolink:Association ;
    skos:definition "Added in response to capturing relationship between microbiome activities as measured via measurements of blood analytes as collected via blood and stool samples" .

biolink:MolecularActivityToPathwayAssociation a owl:Class ;
    rdfs:label "molecular activity to pathway association" ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:onClass biolink:Pathway ;
            owl:onProperty rdf:object ;
            owl:qualifiedCardinality 1 ],
        [ a owl:Restriction ;
            owl:onClass biolink:MolecularActivity ;
            owl:onProperty rdf:subject ;
            owl:qualifiedCardinality 1 ],
        [ a owl:Restriction ;
            owl:onClass biolink:PredicateType ;
            owl:onProperty rdf:predicate ;
            owl:qualifiedCardinality 1 ],
        biolink:Association ;
    skos:definition "Association that holds the relationship between a reaction and the pathway it participates in." .

biolink:MortalityOutcome a owl:Class ;
    rdfs:label "mortality outcome" ;
    rdfs:subClassOf biolink:Outcome ;
    skos:definition "An outcome of death from resulting from an exposure event." .

biolink:NamedThingAssociatedWithLikelihoodOfNamedThingAssociation a owl:Class ;
    rdfs:label "named thing associated with likelihood of named thing association" ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:onClass biolink:PredicateType ;
            owl:onProperty rdf:predicate ;
            owl:qualifiedCardinality 1 ],
        [ a owl:Restriction ;
            owl:maxQualifiedCardinality 1 ;
            owl:onClass biolink:OntologyClass ;
            owl:onProperty biolink:subject_context_qualifier ],
        [ a owl:Restriction ;
            owl:maxQualifiedCardinality 1 ;
            owl:onClass linkml:String ;
            owl:onProperty biolink:subject_aspect_qualifier ],
        [ a owl:Restriction ;
            owl:maxQualifiedCardinality 1 ;
            owl:onClass biolink:OntologyClass ;
            owl:onProperty biolink:object_context_qualifier ],
        [ a owl:Restriction ;
            owl:maxQualifiedCardinality 1 ;
            owl:onClass linkml:String ;
            owl:onProperty biolink:object_aspect_qualifier ],
        biolink:Association ;
    skos:definition "" .

biolink:NucleicAcidSequenceMotif a owl:Class ;
    rdfs:label "nucleic acid sequence motif" ;
    rdfs:subClassOf biolink:BiologicalEntity ;
    skos:altLabel "consensus sequence" ;
    skos:definition "A linear nucleotide sequence pattern that is widespread and has, or is conjectured to have, a biological significance. e.g. the TATA box promoter motif, transcription factor binding consensus sequences." .

biolink:NucleosomeModification a owl:Class ;
    rdfs:label "nucleosome modification" ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:maxQualifiedCardinality 1 ;
            owl:onClass biolink:BiologicalSequence ;
            owl:onProperty biolink:has_biological_sequence ],
        [ a owl:Restriction ;
            owl:allValuesFrom biolink:LabelType ;
            owl:onProperty biolink:synonym ],
        biolink:BiologicalEntity,
        biolink:EpigenomicEntity,
        biolink:GeneProductIsoformMixin,
        biolink:GenomicEntity ;
    skos:definition "A chemical modification of a histone protein within a nucleosome octomer or a substitution of a histone with a variant histone isoform. e.g. Histone 4 Lysine 20 methylation (H4K20me), histone variant H2AZ substituting H2A." .

biolink:ObservedExpectedFrequencyAnalysisResult a owl:Class ;
    rdfs:label "observed expected frequency analysis result" ;
    rdfs:subClassOf biolink:StudyResult ;
    skos:definition "A result of a observed expected frequency analysis." .

biolink:OrganismTaxonToEnvironmentAssociation a owl:Class ;
    rdfs:label "organism taxon to environment association" ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:onClass biolink:PredicateType ;
            owl:onProperty rdf:predicate ;
            owl:qualifiedCardinality 1 ],
        [ a owl:Restriction ;
            owl:onClass biolink:OrganismTaxon ;
            owl:onProperty rdf:subject ;
            owl:qualifiedCardinality 1 ],
        [ a owl:Restriction ;
            owl:onClass biolink:NamedThing ;
            owl:onProperty rdf:object ;
            owl:qualifiedCardinality 1 ],
        biolink:Association,
        biolink:OrganismTaxonToEntityAssociation .

biolink:OrganismTaxonToOrganismTaxonInteraction a owl:Class ;
    rdfs:label "organism taxon to organism taxon interaction" ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:onClass biolink:OrganismTaxon ;
            owl:onProperty rdf:subject ;
            owl:qualifiedCardinality 1 ],
        [ a owl:Restriction ;
            owl:onClass biolink:OrganismTaxon ;
            owl:onProperty rdf:object ;
            owl:qualifiedCardinality 1 ],
        [ a owl:Restriction ;
            owl:onClass biolink:PredicateType ;
            owl:onProperty rdf:predicate ;
            owl:qualifiedCardinality 1 ],
        [ a owl:Restriction ;
            owl:maxQualifiedCardinality 1 ;
            owl:onClass linkml:String ;
            owl:onProperty biolink:associated_environmental_context ],
        biolink:OrganismTaxonToOrganismTaxonAssociation ;
    skos:definition "An interaction relationship between two taxa. This may be a symbiotic relationship (encompassing mutualism and parasitism), or it may be non-symbiotic. Example: plague transmitted_by flea; cattle domesticated_by Homo sapiens; plague infects Homo sapiens" .

biolink:OrganismTaxonToOrganismTaxonSpecialization a owl:Class ;
    rdfs:label "organism taxon to organism taxon specialization" ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:onClass biolink:PredicateType ;
            owl:onProperty rdf:predicate ;
            owl:qualifiedCardinality 1 ],
        [ a owl:Restriction ;
            owl:onClass biolink:OrganismTaxon ;
            owl:onProperty rdf:object ;
            owl:qualifiedCardinality 1 ],
        [ a owl:Restriction ;
            owl:onClass biolink:OrganismTaxon ;
            owl:onProperty rdf:subject ;
            owl:qualifiedCardinality 1 ],
        biolink:OrganismTaxonToOrganismTaxonAssociation ;
    skos:definition "A child-parent relationship between two taxa. For example: Homo sapiens subclass_of Homo" .

biolink:OrganismToOrganismAssociation a owl:Class ;
    rdfs:label "organism to organism association" ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:onClass biolink:IndividualOrganism ;
            owl:onProperty rdf:subject ;
            owl:qualifiedCardinality 1 ],
        [ a owl:Restriction ;
            owl:onClass biolink:IndividualOrganism ;
            owl:onProperty rdf:object ;
            owl:qualifiedCardinality 1 ],
        biolink:Association .

biolink:OrganismalEntityAsAModelOfDiseaseAssociation a owl:Class ;
    rdfs:label "organismal entity as a model of disease association" ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:maxQualifiedCardinality 1 ;
            owl:onClass biolink:FrequencyValue ;
            owl:onProperty biolink:frequency_qualifier ],
        [ a owl:Restriction ;
            owl:onClass biolink:OrganismalEntity ;
            owl:onProperty rdf:subject ;
            owl:qualifiedCardinality 1 ],
        [ a owl:Restriction ;
            owl:maxQualifiedCardinality 1 ;
            owl:onClass biolink:Onset ;
            owl:onProperty biolink:onset_qualifier ],
        [ a owl:Restriction ;
            owl:maxQualifiedCardinality 1 ;
            owl:onClass biolink:SeverityValue ;
            owl:onProperty biolink:severity_qualifier ],
        biolink:Association,
        biolink:EntityToDiseaseAssociationMixin,
        biolink:ModelToDiseaseAssociationMixin .

biolink:PairwiseMolecularInteraction a owl:Class ;
    rdfs:label "pairwise molecular interaction" ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:onClass biolink:MolecularEntity ;
            owl:onProperty rdf:subject ;
            owl:qualifiedCardinality 1 ],
        [ a owl:Restriction ;
            owl:maxQualifiedCardinality 1 ;
            owl:onClass biolink:OntologyClass ;
            owl:onProperty biolink:interacting_molecules_category ],
        [ a owl:Restriction ;
            owl:onClass linkml:String ;
            owl:onProperty biolink:id ;
            owl:qualifiedCardinality 1 ],
        [ a owl:Restriction ;
            owl:onClass biolink:PredicateType ;
            owl:onProperty rdf:predicate ;
            owl:qualifiedCardinality 1 ],
        [ a owl:Restriction ;
            owl:onClass biolink:MolecularEntity ;
            owl:onProperty rdf:object ;
            owl:qualifiedCardinality 1 ],
        biolink:PairwiseGeneToGeneInteraction ;
    skos:definition "An interaction at the molecular level between two physical entities" .

biolink:PathognomonicityQuantifier a owl:Class ;
    rdfs:label "pathognomonicity quantifier" ;
    rdfs:subClassOf biolink:SpecificityQuantifier,
        linkml:mixin ;
    skos:definition "A relationship quantifier between a variant or symptom and a disease, which is high when the presence of the feature implies the existence of the disease" .

biolink:PathologicalAnatomicalExposure a owl:Class ;
    rdfs:label "pathological anatomical exposure" ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:maxQualifiedCardinality 1 ;
            owl:onClass biolink:TimeType ;
            owl:onProperty biolink:timepoint ],
        biolink:Attribute,
        biolink:ExposureEvent ;
    skos:definition "An abnormal anatomical structure, when viewed as an exposure, representing an precondition, leading to or influencing an outcome, e.g. thrombosis leading to an ischemic disease outcome." .

biolink:PathologicalAnatomicalOutcome a owl:Class ;
    rdfs:label "pathological anatomical outcome" ;
    rdfs:subClassOf biolink:Outcome ;
    skos:definition "An outcome resulting from an exposure event which is the manifestation of an abnormal anatomical structure." .

biolink:PathologicalAnatomicalStructure a owl:Class ;
    rdfs:label "pathological anatomical structure" ;
    rdfs:subClassOf biolink:AnatomicalEntity,
        biolink:PathologicalEntityMixin ;
    skos:definition "An anatomical structure with the potential of have an abnormal or deleterious effect at the subcellular, cellular, multicellular, or organismal level." .

biolink:PathologicalProcess a owl:Class ;
    rdfs:label "pathological process" ;
    rdfs:subClassOf biolink:BiologicalProcess,
        biolink:PathologicalEntityMixin ;
    skos:definition "A biologic function or a process having an abnormal or deleterious effect at the subcellular, cellular, multicellular, or organismal level." ;
    skos:exactMatch <http://purl.obolibrary.org/obo/NCIT_C16956>,
        <http://purl.obolibrary.org/obo/OBI_1110122> ;
    skos:narrowMatch STY:T037,
        STY:T046,
        <http://purl.obolibrary.org/obo/NCIT_C19151>,
        EFO:0009708 .

biolink:PathologicalProcessExposure a owl:Class ;
    rdfs:label "pathological process exposure" ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:maxQualifiedCardinality 1 ;
            owl:onClass biolink:TimeType ;
            owl:onProperty biolink:timepoint ],
        biolink:Attribute,
        biolink:ExposureEvent ;
    skos:definition "A pathological process, when viewed as an exposure, representing a precondition, leading to or influencing an outcome, e.g. autoimmunity leading to disease." .

biolink:PathologicalProcessOutcome a owl:Class ;
    rdfs:label "pathological process outcome" ;
    rdfs:subClassOf biolink:Outcome ;
    skos:definition "An outcome resulting from an exposure event which is the manifestation of a pathological process." .

biolink:PercentageFrequencyValue a owl:Class ;
    rdfs:label "percentage frequency value" ;
    rdfs:subClassOf linkml:Double .

biolink:Phenomenon a owl:Class ;
    rdfs:label "phenomenon" ;
    rdfs:subClassOf biolink:NamedThing,
        biolink:Occurrent ;
    skos:broadMatch STY:T067,
        STY:T068,
        STY:T070 ;
    skos:definition "a fact or situation that is observed to exist or happen, especially one whose cause or explanation is in question" ;
    skos:exactMatch UMLSSG:PHEN ;
    skos:narrowMatch STY:T034,
        STY:T038,
        STY:T069 .

biolink:PhenotypicQuality a owl:Class ;
    rdfs:label "phenotypic quality" ;
    rdfs:subClassOf biolink:OrganismAttribute ;
    skos:altLabel "phenotypic properties" ;
    skos:definition "A property of a phenotype" ;
    skos:exactMatch <http://purl.obolibrary.org/obo/PATO_0000001> ;
    linkml:examples "Example(value='weight', description=None)" .

biolink:PhenotypicSex a owl:Class ;
    rdfs:label "phenotypic sex" ;
    rdfs:subClassOf biolink:BiologicalSex ;
    skos:definition "An attribute corresponding to the phenotypic sex of the individual, based upon the reproductive organs present." ;
    skos:exactMatch <http://purl.obolibrary.org/obo/PATO_0001894> .

biolink:PhysiologicalProcess a owl:Class ;
    rdfs:label "physiological process" ;
    rdfs:subClassOf biolink:BiologicalProcess,
        biolink:OntologyClass ;
    skos:altLabel "physiology" ;
    skos:exactMatch STY:T039,
        WIKIDATA:Q30892994 ;
    skos:narrowMatch STY:T040,
        STY:T042,
        STY:T043,
        STY:T045 .

biolink:PopulationToPopulationAssociation a owl:Class ;
    rdfs:label "population to population association" ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:onClass biolink:PopulationOfIndividualOrganisms ;
            owl:onProperty rdf:subject ;
            owl:qualifiedCardinality 1 ],
        [ a owl:Restriction ;
            owl:onClass biolink:PopulationOfIndividualOrganisms ;
            owl:onProperty rdf:object ;
            owl:qualifiedCardinality 1 ],
        [ a owl:Restriction ;
            owl:onClass biolink:PredicateType ;
            owl:onProperty rdf:predicate ;
            owl:qualifiedCardinality 1 ],
        biolink:Association ;
    skos:definition "An association between a two populations" .

biolink:PosttranslationalModification a owl:Class ;
    rdfs:label "posttranslational modification" ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:allValuesFrom biolink:LabelType ;
            owl:onProperty biolink:synonym ],
        biolink:BiologicalEntity,
        biolink:GeneProductIsoformMixin ;
    skos:definition "A chemical modification of a polypeptide or protein that occurs after translation.  e.g. polypeptide cleavage to form separate proteins, methylation or acetylation of histone tail amino acids,  protein ubiquitination." .

biolink:ProcessedMaterial a owl:Class ;
    rdfs:label "processed material" ;
    rdfs:subClassOf biolink:ChemicalMixture ;
    skos:definition "A chemical entity (often a mixture) processed for consumption for nutritional, medical or technical use. Is a material entity that is created or changed during material processing." ;
    skos:exactMatch <http://purl.obolibrary.org/obo/OBI_0000047> .

biolink:ProteinDomain a owl:Class ;
    rdfs:label "protein domain" ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:allValuesFrom biolink:Gene ;
            owl:onProperty biolink:has_gene_or_gene_product ],
        biolink:BiologicalEntity,
        biolink:ChemicalEntityOrGeneOrGeneProduct,
        biolink:GeneGroupingMixin ;
    skos:definition "A conserved part of protein sequence and (tertiary) structure that can evolve, function, and exist independently of the rest of the protein chain. Protein domains maintain their structure and function independently of the proteins in which they are found. e.g. an SH3 domain." ;
    skos:exactMatch <http://identifiers.org/umls/C1514562>,
        <http://purl.obolibrary.org/obo/NCIT_C13379>,
        SIO:001379 .

biolink:ProteinFamily a owl:Class ;
    rdfs:label "protein family" ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:allValuesFrom biolink:Gene ;
            owl:onProperty biolink:has_gene_or_gene_product ],
        biolink:BiologicalEntity,
        biolink:ChemicalEntityOrGeneOrGeneProduct,
        biolink:GeneGroupingMixin ;
    skos:exactMatch <http://purl.obolibrary.org/obo/NCIT_C26004>,
        WIKIDATA:Q2278983 ;
    skos:narrowMatch <http://purl.obolibrary.org/obo/NCIT_C20130>,
        SIO:001380,
        WIKIDATA:Q417841 .

biolink:ProteinIsoform a owl:Class ;
    rdfs:label "protein isoform" ;
    rdfs:subClassOf biolink:GeneProductIsoformMixin,
        biolink:Protein ;
    skos:altLabel "proteoform" ;
    skos:definition "Represents a protein that is a specific isoform of the canonical or reference protein. See https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4114032/" .

biolink:Quotient a owl:Class ;
    rdfs:label "quotient" ;
    rdfs:subClassOf linkml:Double .

biolink:RNAProductIsoform a owl:Class ;
    rdfs:label "RNA product isoform" ;
    rdfs:subClassOf biolink:GeneProductIsoformMixin,
        biolink:RNAProduct ;
    skos:definition "Represents a protein that is a specific isoform of the canonical or reference RNA" .

biolink:ReactionToCatalystAssociation a owl:Class ;
    rdfs:label "reaction to catalyst association" ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:onClass biolink:GeneOrGeneProduct ;
            owl:onProperty rdf:object ;
            owl:qualifiedCardinality 1 ],
        biolink:ReactionToParticipantAssociation .

biolink:ReagentTargetedGene a owl:Class ;
    rdfs:label "reagent targeted gene" ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:maxQualifiedCardinality 1 ;
            owl:onClass biolink:BiologicalSequence ;
            owl:onProperty biolink:has_biological_sequence ],
        biolink:BiologicalEntity,
        biolink:GenomicEntity,
        biolink:OntologyClass,
        biolink:PhysicalEssence ;
    skos:altLabel "sequence targeting reagent" ;
    skos:definition "A gene altered in its expression level in the context of some experiment as a result of being targeted by gene-knockdown reagent(s) such as a morpholino or RNAi." ;
    skos:exactMatch <http://purl.obolibrary.org/obo/GENO_0000504> .

biolink:RelationshipType a owl:Class ;
    rdfs:label "relationship type" ;
    rdfs:subClassOf biolink:OntologyClass ;
    skos:definition "An OWL property used as an edge label" .

biolink:RelativeFrequencyAnalysisResult a owl:Class ;
    rdfs:label "relative frequency analysis result" ;
    rdfs:subClassOf biolink:StudyResult ;
    skos:definition "A result of a relative frequency analysis." .

biolink:SensitivityQuantifier a owl:Class ;
    rdfs:label "sensitivity quantifier" ;
    rdfs:subClassOf biolink:RelationshipQuantifier,
        linkml:mixin .

biolink:SequenceEnum a owl:Class ;
    rdfs:label "SequenceEnum" ;
    owl:unionOf ( <https://w3id.org/biolink/vocab/SequenceEnum#na> <https://w3id.org/biolink/vocab/SequenceEnum#aa> ) ;
    linkml:permissible_values <https://w3id.org/biolink/vocab/SequenceEnum#aa>,
        <https://w3id.org/biolink/vocab/SequenceEnum#na> .

biolink:SequenceVariantModulatesTreatmentAssociation a owl:Class ;
    rdfs:label "sequence variant modulates treatment association" ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:onClass biolink:Treatment ;
            owl:onProperty rdf:object ;
            owl:qualifiedCardinality 1 ],
        [ a owl:Restriction ;
            owl:onClass biolink:SequenceVariant ;
            owl:onProperty rdf:subject ;
            owl:qualifiedCardinality 1 ],
        biolink:Association ;
    skos:definition "An association between a sequence variant and a treatment or health intervention. The treatment object itself encompasses both the disease and the drug used." ;
    skos:note "An alternate way to model the same information could be via a qualifier" .

biolink:Serial a owl:Class ;
    rdfs:label "serial" ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:maxQualifiedCardinality 1 ;
            owl:onClass linkml:String ;
            owl:onProperty biolink:issue ],
        [ a owl:Restriction ;
            owl:onClass linkml:String ;
            owl:onProperty biolink:id ;
            owl:qualifiedCardinality 1 ],
        [ a owl:Restriction ;
            owl:maxQualifiedCardinality 1 ;
            owl:onClass linkml:String ;
            owl:onProperty biolink:volume ],
        [ a owl:Restriction ;
            owl:maxQualifiedCardinality 1 ;
            owl:onClass linkml:String ;
            owl:onProperty biolink:iso_abbreviation ],
        [ a owl:Restriction ;
            owl:allValuesFrom linkml:String ;
            owl:onProperty rdf:type ],
        biolink:Publication ;
    skos:altLabel "journal" ;
    skos:definition "This class may rarely be instantiated except if use cases of a given knowledge graph support its utility." .

biolink:SiRNA a owl:Class ;
    rdfs:label "siRNA" ;
    rdfs:subClassOf biolink:NoncodingRNAProduct ;
    skos:altLabel "RNAi",
        "small interfering RNA" ;
    skos:definition "A small RNA molecule that is the product of a longer exogenous or endogenous dsRNA, which is either a bimolecular duplex or very long hairpin, processed (via the Dicer pathway) such that numerous siRNAs accumulate from both strands of the dsRNA. SRNAs trigger the cleavage of their target molecules." ;
    skos:exactMatch <http://purl.obolibrary.org/obo/SO_0000646>,
        WIKIDATA:Q203221 .

biolink:SmallMolecule a owl:Class ;
    rdfs:label "small molecule" ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:onClass linkml:String ;
            owl:onProperty biolink:id ;
            owl:qualifiedCardinality 1 ],
        biolink:MolecularEntity ;
    skos:altLabel "chemical substance" ;
    skos:definition "A small molecule entity is a molecular entity characterized by availability in small-molecule databases of SMILES, InChI, IUPAC, or other unambiguous representation of its precise chemical structure; for convenience of representation, any valid chemical representation is included, even if it is not strictly molecular (e.g., sodium ion)." ;
    skos:narrowMatch STY:T109,
        STY:T110,
        STY:T111,
        STY:T115,
        STY:T118,
        STY:T119,
        STY:T123,
        STY:T124,
        STY:T125,
        STY:T127,
        STY:T131,
        STY:T196,
        STY:T197,
        <http://purl.obolibrary.org/obo/CHEBI_59999>,
        bioschemas:ChemicalSubstance .

biolink:Snv a owl:Class ;
    rdfs:label "snv" ;
    rdfs:subClassOf biolink:SequenceVariant ;
    skos:altLabel "single nucleotide polymorphism",
        "single nucleotide variant",
        "snp" ;
    skos:definition "SNVs are single nucleotide positions in genomic DNA at which different sequence alternatives exist" ;
    skos:exactMatch <http://purl.obolibrary.org/obo/SO_0001483> .

biolink:SocioeconomicExposure a owl:Class ;
    rdfs:label "socioeconomic exposure" ;
    rdfs:subClassOf [ a owl:Class ;
            owl:intersectionOf ( [ a owl:Restriction ;
                        owl:allValuesFrom biolink:SocioeconomicAttribute ;
                        owl:onProperty biolink:has_attribute ] [ a owl:Restriction ;
                        owl:onProperty biolink:has_attribute ;
                        owl:someValuesFrom biolink:SocioeconomicAttribute ] ) ],
        [ a owl:Restriction ;
            owl:maxQualifiedCardinality 1 ;
            owl:onClass biolink:TimeType ;
            owl:onProperty biolink:timepoint ],
        biolink:Attribute,
        biolink:ExposureEvent ;
    skos:definition "A socioeconomic exposure is a factor relating to social and financial status of an affected individual (e.g. poverty)." .

biolink:SocioeconomicOutcome a owl:Class ;
    rdfs:label "socioeconomic outcome" ;
    rdfs:subClassOf biolink:Outcome ;
    skos:definition "An general social or economic outcome, such as healthcare costs, utilization, etc., resulting from an exposure event" .

biolink:Study a owl:Class ;
    rdfs:label "study" ;
    rdfs:subClassOf biolink:InformationContentEntity ;
    skos:closeMatch <http://purl.obolibrary.org/obo/SEPIO_0000004>,
        SIO:001066 ;
    skos:definition "a detailed investigation and/or analysis" ;
    skos:exactMatch <http://purl.obolibrary.org/obo/NCIT_C63536> ;
    skos:narrowMatch SIO:000994 .

biolink:StudyVariable a owl:Class ;
    rdfs:label "study variable" ;
    rdfs:subClassOf biolink:InformationContentEntity ;
    skos:closeMatch <http://purl.obolibrary.org/obo/STATO_0000258>,
        SIO:000367 ;
    skos:definition "a variable that is used as a measure in the investigation of a study" ;
    skos:narrowMatch <http://purl.obolibrary.org/obo/NCIT_C142192> .

biolink:TaxonToTaxonAssociation a owl:Class ;
    rdfs:label "taxon to taxon association" ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:onClass biolink:OrganismTaxon ;
            owl:onProperty rdf:subject ;
            owl:qualifiedCardinality 1 ],
        [ a owl:Restriction ;
            owl:onClass biolink:OrganismTaxon ;
            owl:onProperty rdf:object ;
            owl:qualifiedCardinality 1 ],
        biolink:Association .

biolink:TextMiningResult a owl:Class ;
    rdfs:label "text mining result" ;
    rdfs:subClassOf biolink:StudyResult ;
    skos:definition "A result of text mining." .

biolink:TranscriptToGeneRelationship a owl:Class ;
    rdfs:label "transcript to gene relationship" ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:onClass biolink:Transcript ;
            owl:onProperty rdf:subject ;
            owl:qualifiedCardinality 1 ],
        [ a owl:Restriction ;
            owl:onClass biolink:Gene ;
            owl:onProperty rdf:object ;
            owl:qualifiedCardinality 1 ],
        biolink:SequenceFeatureRelationship ;
    skos:definition "A gene is a collection of transcripts" .

biolink:VariantAsAModelOfDiseaseAssociation a owl:Class ;
    rdfs:label "variant as a model of disease association" ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:onClass biolink:SequenceVariant ;
            owl:onProperty rdf:subject ;
            owl:qualifiedCardinality 1 ],
        biolink:EntityToDiseaseAssociationMixin,
        biolink:ModelToDiseaseAssociationMixin,
        biolink:VariantToDiseaseAssociation .

biolink:VariantToGeneExpressionAssociation a owl:Class ;
    rdfs:label "variant to gene expression association" ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:maxQualifiedCardinality 1 ;
            owl:onClass biolink:AnatomicalEntity ;
            owl:onProperty biolink:expression_site ],
        [ a owl:Restriction ;
            owl:maxQualifiedCardinality 1 ;
            owl:onClass biolink:LifeStage ;
            owl:onProperty biolink:stage_qualifier ],
        [ a owl:Restriction ;
            owl:onClass biolink:PredicateType ;
            owl:onProperty rdf:predicate ;
            owl:qualifiedCardinality 1 ],
        [ a owl:Restriction ;
            owl:maxQualifiedCardinality 1 ;
            owl:onClass biolink:DiseaseOrPhenotypicFeature ;
            owl:onProperty biolink:phenotypic_state ],
        [ a owl:Restriction ;
            owl:maxQualifiedCardinality 1 ;
            owl:onClass biolink:OntologyClass ;
            owl:onProperty biolink:quantifier_qualifier ],
        biolink:GeneExpressionMixin,
        biolink:VariantToGeneAssociation ;
    skos:definition "An association between a variant and expression of a gene (i.e. e-QTL)" .

biolink:VariantToPhenotypicFeatureAssociation a owl:Class ;
    rdfs:label "variant to phenotypic feature association" ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:maxQualifiedCardinality 1 ;
            owl:onClass biolink:BiologicalSex ;
            owl:onProperty biolink:sex_qualifier ],
        [ a owl:Restriction ;
            owl:maxQualifiedCardinality 1 ;
            owl:onClass biolink:FrequencyValue ;
            owl:onProperty biolink:frequency_qualifier ],
        [ a owl:Restriction ;
            owl:maxQualifiedCardinality 1 ;
            owl:onClass biolink:SeverityValue ;
            owl:onProperty biolink:severity_qualifier ],
        [ a owl:Restriction ;
            owl:onClass biolink:SequenceVariant ;
            owl:onProperty rdf:subject ;
            owl:qualifiedCardinality 1 ],
        [ a owl:Restriction ;
            owl:maxQualifiedCardinality 1 ;
            owl:onClass linkml:Double ;
            owl:onProperty biolink:has_percentage ],
        [ a owl:Restriction ;
            owl:maxQualifiedCardinality 1 ;
            owl:onClass biolink:Onset ;
            owl:onProperty biolink:onset_qualifier ],
        [ a owl:Restriction ;
            owl:maxQualifiedCardinality 1 ;
            owl:onClass linkml:Integer ;
            owl:onProperty biolink:has_total ],
        [ a owl:Restriction ;
            owl:maxQualifiedCardinality 1 ;
            owl:onClass linkml:Double ;
            owl:onProperty biolink:has_quotient ],
        [ a owl:Restriction ;
            owl:maxQualifiedCardinality 1 ;
            owl:onClass linkml:Integer ;
            owl:onProperty biolink:has_count ],
        biolink:Association,
        biolink:EntityToPhenotypicFeatureAssociationMixin,
        biolink:VariantToEntityAssociationMixin .

biolink:VariantToPopulationAssociation a owl:Class ;
    rdfs:label "variant to population association" ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:maxQualifiedCardinality 1 ;
            owl:onClass biolink:FrequencyValue ;
            owl:onProperty biolink:frequency_qualifier ],
        [ a owl:Restriction ;
            owl:maxQualifiedCardinality 1 ;
            owl:onClass linkml:Double ;
            owl:onProperty biolink:has_quotient ],
        [ a owl:Restriction ;
            owl:maxQualifiedCardinality 1 ;
            owl:onClass linkml:Double ;
            owl:onProperty biolink:has_percentage ],
        [ a owl:Restriction ;
            owl:onClass biolink:SequenceVariant ;
            owl:onProperty rdf:subject ;
            owl:qualifiedCardinality 1 ],
        [ a owl:Restriction ;
            owl:maxQualifiedCardinality 1 ;
            owl:onClass linkml:Integer ;
            owl:onProperty biolink:has_count ],
        [ a owl:Restriction ;
            owl:onClass biolink:PopulationOfIndividualOrganisms ;
            owl:onProperty rdf:object ;
            owl:qualifiedCardinality 1 ],
        [ a owl:Restriction ;
            owl:maxQualifiedCardinality 1 ;
            owl:onClass linkml:Integer ;
            owl:onProperty biolink:has_total ],
        biolink:Association,
        biolink:FrequencyQualifierMixin,
        biolink:FrequencyQuantifier,
        biolink:VariantToEntityAssociationMixin ;
    skos:definition "An association between a variant and a population, where the variant has particular frequency in the population" .

biolink:Virus a owl:Class ;
    rdfs:label "virus" ;
    rdfs:subClassOf biolink:OrganismalEntity,
        biolink:SubjectOfInvestigation ;
    skos:definition "A virus is a microorganism that replicates itself as a microRNA and infects the host cell." ;
    skos:exactMatch <http://purl.obolibrary.org/obo/NCBITaxon_10239> .

biolink:animal_model_available_from a owl:ObjectProperty ;
    rdfs:label "animal model available from" ;
    rdfs:domain biolink:NamedThing ;
    rdfs:range biolink:DiseaseOrPhenotypicFeature ;
    rdfs:subPropertyOf biolink:node_property ;
    skos:definition "" .

biolink:binds a owl:ObjectProperty,
        owl:SymmetricProperty ;
    rdfs:label "binds" ;
    rdfs:domain biolink:NamedThing ;
    rdfs:range biolink:NamedThing ;
    rdfs:subPropertyOf biolink:directly_physically_interacts_with ;
    skos:closeMatch DGIdb:binder ;
    skos:definition "A causal mechanism mediated by the direct contact between effector and target chemical or biomolecular entity,  which form a stable physical interaction." ;
    biolink:canonical_predicate "True" .

biolink:biological_role_mixin a owl:ObjectProperty ;
    rdfs:label "biological role mixin" ;
    rdfs:range linkml:String ;
    skos:definition "A role played by the chemical entity or part thereof within a biological context." ;
    skos:narrowMatch <http://purl.obolibrary.org/obo/CHEBI_24432> .

biolink:bonferonni_adjusted_p_value a owl:ObjectProperty ;
    rdfs:label "bonferonni adjusted p value" ;
    rdfs:domain biolink:Association ;
    rdfs:range linkml:Float ;
    rdfs:subPropertyOf biolink:adjusted_p_value ;
    skos:definition "The Bonferroni correction is an adjustment made to P values when several dependent or independent  statistical tests are being performed simultaneously on a single data set. To perform a Bonferroni  correction, divide the critical P value (α) by the number of comparisons being made.  P is always italicized and  capitalized. The actual P value* should be expressed (P=. 04) rather than expressing a statement of inequality  (P<. 05), unless P<." ;
    linkml:examples "Example(value='0.018', description=None)" .

biolink:broad_matches a owl:ObjectProperty ;
    rdfs:label "broad matches" ;
    rdfs:range linkml:String ;
    skos:definition "A list of terms from different schemas or terminology systems that have a broader meaning. Such terms often describe a more general concept from different ontological perspectives." .

biolink:broad_synonym a owl:ObjectProperty ;
    rdfs:label "broad synonym" ;
    rdfs:domain biolink:NamedThing ;
    rdfs:range biolink:LabelType ;
    rdfs:subPropertyOf biolink:synonym ;
    skos:exactMatch oboformat:hasBroadSynonym .

biolink:chemical_role_mixin a owl:ObjectProperty ;
    rdfs:label "chemical role mixin" ;
    rdfs:range linkml:String ;
    skos:definition "A role played by the chemical entity or part thereof within a chemical context." ;
    skos:exactMatch <http://purl.obolibrary.org/obo/CHEBI_51086> .

biolink:chemically_similar_to a owl:ObjectProperty,
        owl:SymmetricProperty ;
    rdfs:label "chemically similar to" ;
    rdfs:domain biolink:NamedThing ;
    rdfs:range biolink:NamedThing ;
    rdfs:subPropertyOf biolink:similar_to ;
    skos:definition "holds between one small molecule entity and another that it approximates for purposes of scientific study, in virtue of its exhibiting similar features of the studied entity." ;
    skos:narrowMatch <http://purl.obolibrary.org/obo/CHEBI_has_functional_parent>,
        <http://purl.obolibrary.org/obo/CHEBI_has_parent_hydride>,
        <http://purl.obolibrary.org/obo/CHEBI_is_conjugate_acid_of>,
        <http://purl.obolibrary.org/obo/CHEBI_is_conjugate_base_of>,
        <http://purl.obolibrary.org/obo/CHEBI_is_enantiomer_of>,
        <http://purl.obolibrary.org/obo/CHEBI_is_tautomer_of>,
        <http://purl.obolibrary.org/obo/NCIT_has_salt_form> ;
    biolink:canonical_predicate "True" .

biolink:chi_squared_statistic a owl:ObjectProperty ;
    rdfs:label "chi squared statistic" ;
    rdfs:domain biolink:Association ;
    rdfs:range linkml:Float ;
    rdfs:subPropertyOf biolink:association_slot ;
    skos:definition "represents the chi-squared statistic computed from observations" ;
    skos:exactMatch <http://purl.obolibrary.org/obo/STATO_0000030> .

biolink:clinical_modifier_qualifier a owl:ObjectProperty ;
    rdfs:label "clinical modifier qualifier" ;
    rdfs:domain biolink:Association ;
    rdfs:range biolink:ClinicalModifier ;
    rdfs:subPropertyOf biolink:association_slot ;
    skos:definition "the method or process of administering a pharmaceutical compound to achieve a therapeutic effect in humans or animals." .

biolink:coexpressed_with a owl:ObjectProperty,
        owl:SymmetricProperty ;
    rdfs:label "coexpressed with" ;
    rdfs:domain biolink:GeneOrGeneProduct ;
    rdfs:range biolink:GeneOrGeneProduct ;
    rdfs:subPropertyOf biolink:correlated_with ;
    skos:definition "holds between any two genes or gene products, in which both are generally expressed within a single defined experimental context." ;
    biolink:canonical_predicate "True" .

biolink:colocalizes_with a owl:ObjectProperty,
        owl:SymmetricProperty ;
    rdfs:label "colocalizes with" ;
    rdfs:domain biolink:NamedThing ;
    rdfs:range biolink:NamedThing ;
    rdfs:subPropertyOf biolink:coexists_with ;
    skos:definition "holds between two entities that are observed to be located in the same place." ;
    skos:exactMatch RO:00002325 ;
    biolink:canonical_predicate "True" .

biolink:concept_count_object a owl:ObjectProperty ;
    rdfs:label "concept count object" ;
    rdfs:domain biolink:Association ;
    rdfs:range linkml:Integer ;
    rdfs:subPropertyOf biolink:association_slot ;
    skos:definition "The number of instances in a dataset/cohort whose records contain the concept in the object slot of an association." .

biolink:concept_count_subject a owl:ObjectProperty ;
    rdfs:label "concept count subject" ;
    rdfs:domain biolink:Association ;
    rdfs:range linkml:Integer ;
    rdfs:subPropertyOf biolink:association_slot ;
    skos:definition "The number of instances in a dataset/cohort whose records contain the concept in the subject slot of an association." ;
    linkml:examples "Example(value='489', description=None)" .

biolink:concept_pair_count a owl:ObjectProperty ;
    rdfs:label "concept pair count" ;
    rdfs:domain biolink:Association ;
    rdfs:range linkml:Integer ;
    rdfs:subPropertyOf biolink:association_slot ;
    skos:definition "The number of instances in a dataset/cohort whose records contain both the subject and object concept of an association." ;
    linkml:examples "Example(value='1731', description=None)" .

biolink:created_with a owl:ObjectProperty ;
    rdfs:label "created with" ;
    rdfs:domain biolink:Dataset ;
    rdfs:range linkml:String ;
    rdfs:subPropertyOf biolink:node_property ;
    skos:exactMatch pav:createdWith .

biolink:end_coordinate a owl:ObjectProperty ;
    rdfs:label "end coordinate" ;
    rdfs:domain biolink:GenomicSequenceLocalization ;
    rdfs:range linkml:Integer ;
    rdfs:subPropertyOf biolink:base_coordinate ;
    skos:altLabel "end" ;
    skos:closeMatch <http://biohackathon.org/resource/faldo#end> ;
    skos:definition "The position at which the subject genomic entity ends on the chromosome or other entity to which it is located on." ;
    skos:exactMatch gff3:end .

biolink:evidence_count a owl:ObjectProperty ;
    rdfs:label "evidence count" ;
    rdfs:domain biolink:Association ;
    rdfs:range linkml:Integer ;
    rdfs:subPropertyOf biolink:association_slot ;
    skos:definition "The number of evidence instances that are connected to an association." .

biolink:exact_matches a owl:ObjectProperty ;
    rdfs:label "exact matches" ;
    rdfs:range linkml:String ;
    skos:definition "A list of terms from different schemas or terminology systems that have an identical meaning. Such terms often describe the same concept from different ontological perspectives." .

biolink:exact_synonym a owl:ObjectProperty ;
    rdfs:label "exact synonym" ;
    rdfs:domain biolink:NamedThing ;
    rdfs:range biolink:LabelType ;
    rdfs:subPropertyOf biolink:synonym ;
    skos:exactMatch oboformat:hasExactSynonym .

biolink:expected_count a owl:ObjectProperty ;
    rdfs:label "expected count" ;
    rdfs:domain biolink:Association ;
    rdfs:range linkml:String ;
    rdfs:subPropertyOf biolink:association_slot ;
    skos:definition "The expected (calculated) number of instances in a dataset/cohort whose records contain both the subject and  object concept of an association if the subject and object concepts are independent." .

biolink:extraction_confidence_score a owl:ObjectProperty ;
    rdfs:label "extraction confidence score" ;
    rdfs:domain biolink:Association ;
    rdfs:range linkml:Integer ;
    rdfs:subPropertyOf biolink:association_slot ;
    skos:definition "A quantitative confidence value that represents the probability of obtaining a result at least as extreme as that actually obtained, assuming that the actual value was the result of chance alone." ;
    linkml:examples "Example(value='15', description=None)" .

biolink:full_name a owl:ObjectProperty ;
    rdfs:label "full name" ;
    rdfs:domain biolink:NamedThing ;
    rdfs:range biolink:LabelType ;
    rdfs:subPropertyOf biolink:node_property ;
    skos:definition "a long-form human readable name for a thing" .

biolink:genetically_interacts_with a owl:ObjectProperty,
        owl:SymmetricProperty ;
    rdfs:label "genetically interacts with" ;
    rdfs:domain biolink:Gene ;
    rdfs:range biolink:Gene ;
    rdfs:subPropertyOf biolink:interacts_with ;
    skos:definition "holds between two genes whose phenotypic effects are dependent on each other in some way - such that their combined phenotypic effects are the result of some interaction between the activity of their gene products. Examples include epistasis and synthetic lethality." ;
    skos:exactMatch RO:0002435 ;
    biolink:canonical_predicate "True" .

biolink:has_chemical_formula a owl:ObjectProperty ;
    rdfs:label "has chemical formula" ;
    rdfs:domain biolink:NamedThing ;
    rdfs:range biolink:ChemicalFormulaValue ;
    rdfs:subPropertyOf biolink:node_property ;
    skos:definition "description of chemical compound based on element symbols" ;
    skos:exactMatch WIKIDATA_PROPERTY:P274 .

biolink:has_confidence_level a owl:ObjectProperty ;
    rdfs:label "has confidence level" ;
    rdfs:domain biolink:Association ;
    rdfs:range biolink:ConfidenceLevel ;
    rdfs:subPropertyOf biolink:association_slot ;
    skos:definition "connects an association to a qualitative term denoting the level of confidence" .

biolink:has_constituent a owl:ObjectProperty ;
    rdfs:label "has constituent" ;
    rdfs:domain biolink:NamedThing ;
    rdfs:range biolink:MolecularEntity ;
    rdfs:subPropertyOf biolink:node_property ;
    skos:definition "one or more molecular entities within a chemical mixture" .

biolink:has_receptor a owl:ObjectProperty ;
    rdfs:label "has receptor" ;
    rdfs:domain biolink:ExposureEvent ;
    rdfs:range biolink:OrganismalEntity ;
    rdfs:subPropertyOf biolink:node_property ;
    skos:definition "the organism or organism part being exposed" ;
    skos:exactMatch ExO:0000001 .

biolink:has_route a owl:ObjectProperty ;
    rdfs:label "has route" ;
    rdfs:domain biolink:ExposureEvent ;
    rdfs:range linkml:String ;
    rdfs:subPropertyOf biolink:node_property ;
    skos:definition "the process that results in the stressor coming into direct contact with the receptor" ;
    skos:exactMatch ExO:0000055 ;
    skos:narrowMatch LOINC:has_pharmaceutical_route,
        <http://purl.obolibrary.org/obo/SNOMED_has_dose_form_intended_site>,
        <http://purl.obolibrary.org/obo/SNOMED_has_route_of_administration> .

biolink:has_stressor a owl:ObjectProperty ;
    rdfs:label "has stressor" ;
    rdfs:domain biolink:ExposureEvent ;
    rdfs:range linkml:String ;
    rdfs:subPropertyOf biolink:node_property ;
    skos:altLabel "has stimulus" ;
    skos:definition "the process or entity that the receptor is being exposed to" ;
    skos:exactMatch ExO:0000000 .

biolink:has_supporting_study_result a owl:ObjectProperty ;
    rdfs:label "has supporting study result" ;
    rdfs:domain biolink:Association ;
    rdfs:range linkml:String ;
    rdfs:subPropertyOf biolink:association_slot ;
    skos:definition "connects an association to an instance of supporting study result" .

biolink:has_topic a owl:ObjectProperty ;
    rdfs:label "has topic" ;
    rdfs:domain biolink:NamedThing ;
    rdfs:range biolink:OntologyClass ;
    rdfs:subPropertyOf biolink:node_property ;
    skos:altLabel "descriptors",
        "topic" ;
    skos:definition "Connects a node to a vocabulary term or ontology class that describes some aspect of the entity. In general specific characterization is preferred. See https://github.com/biolink/biolink-model/issues/238" ;
    skos:exactMatch foaf:topic .

biolink:in_cell_population_with a owl:ObjectProperty,
        owl:SymmetricProperty ;
    rdfs:label "in cell population with" ;
    rdfs:domain biolink:GeneOrGeneProduct ;
    rdfs:range biolink:GeneOrGeneProduct ;
    rdfs:subPropertyOf biolink:coexists_with ;
    skos:definition "holds between two genes or gene products that are expressed in the same cell type or population" ;
    biolink:canonical_predicate "True" .

biolink:in_complex_with a owl:ObjectProperty,
        owl:SymmetricProperty ;
    rdfs:label "in complex with" ;
    rdfs:domain biolink:GeneOrGeneProduct ;
    rdfs:range biolink:GeneOrGeneProduct ;
    rdfs:subPropertyOf biolink:coexists_with ;
    skos:broadMatch SIO:010285 ;
    skos:definition "holds between two genes or gene products that are part of (or code for products that are part of) in the same macromolecular complex" ;
    skos:relatedMatch SIO:010497 ;
    biolink:canonical_predicate "True" .

biolink:in_linkage_disequilibrium_with a owl:ObjectProperty,
        owl:SymmetricProperty ;
    rdfs:label "in linkage disequilibrium with" ;
    rdfs:domain biolink:NamedThing ;
    rdfs:range biolink:NamedThing ;
    rdfs:subPropertyOf biolink:related_to_at_instance_level ;
    skos:definition "holds between two sequence variants, the presence of which are correlated in a population" ;
    skos:exactMatch <http://purl.obolibrary.org/obo/NCIT_C16798> ;
    biolink:canonical_predicate "True" .

biolink:in_pathway_with a owl:ObjectProperty,
        owl:SymmetricProperty ;
    rdfs:label "in pathway with" ;
    rdfs:domain biolink:GeneOrGeneProduct ;
    rdfs:range biolink:GeneOrGeneProduct ;
    rdfs:subPropertyOf biolink:coexists_with ;
    skos:definition "holds between two genes or gene products that are part of in the same biological pathway" ;
    skos:relatedMatch SIO:010532 ;
    biolink:canonical_predicate "True" .

biolink:indirectly_physically_interacts_with a owl:ObjectProperty,
        owl:SymmetricProperty ;
    rdfs:label "indirectly physically interacts with" ;
    rdfs:domain biolink:NamedThing ;
    rdfs:range biolink:NamedThing ;
    rdfs:subPropertyOf biolink:physically_interacts_with ;
    biolink:canonical_predicate "True" .

biolink:ln_ratio a owl:ObjectProperty ;
    rdfs:label "ln ratio" ;
    rdfs:domain biolink:Association ;
    rdfs:range linkml:Float ;
    rdfs:subPropertyOf biolink:association_slot ;
    skos:definition "the natural log of the ratio of co-occurrence to expected" ;
    linkml:examples "Example(value='2.922827136', description=None)" .

biolink:ln_ratio_confidence_interval a owl:ObjectProperty ;
    rdfs:label "ln ratio confidence interval" ;
    rdfs:domain biolink:Association ;
    rdfs:range linkml:Float ;
    rdfs:subPropertyOf biolink:association_slot ;
    skos:definition "The 99% confidence interval for the ln_ratio calculation (i.e. the range of values within which the true value has a 99% chance of falling)" ;
    linkml:examples "Example(value='2.922827136', description=None)" .

biolink:logical_interpretation a owl:ObjectProperty ;
    rdfs:label "logical interpretation" ;
    rdfs:domain biolink:Association ;
    rdfs:range biolink:LogicalInterpretationEnum ;
    rdfs:subPropertyOf biolink:association_slot ;
    skos:exactMatch os:LogicalInterpretation .

biolink:mechanism_of_action a owl:ObjectProperty ;
    rdfs:label "mechanism of action" ;
    rdfs:domain biolink:Association ;
    rdfs:range linkml:Boolean ;
    rdfs:subPropertyOf biolink:association_slot ;
    skos:definition "a boolean flag to indicate if the edge is part of a path or subgraph of a knowledge graph that constitutes the mechanism of action for a result." ;
    skos:exactMatch LOINC:MTHU019741,
        MI:2044,
        <http://purl.obolibrary.org/obo/NCIT_C54680> .

biolink:narrow_matches a owl:ObjectProperty ;
    rdfs:label "narrow matches" ;
    rdfs:range linkml:String ;
    skos:definition "A list of terms from different schemas or terminology systems that have a narrower meaning. Such terms often describe a more specific concept from different ontological perspectives." .

biolink:narrow_synonym a owl:ObjectProperty ;
    rdfs:label "narrow synonym" ;
    rdfs:domain biolink:NamedThing ;
    rdfs:range biolink:LabelType ;
    rdfs:subPropertyOf biolink:synonym ;
    skos:exactMatch oboformat:hasNarrowSynonym .

biolink:negatively_correlated_with a owl:ObjectProperty,
        owl:SymmetricProperty ;
    rdfs:label "negatively correlated with" ;
    rdfs:domain biolink:NamedThing ;
    rdfs:range biolink:NamedThing ;
    rdfs:subPropertyOf biolink:correlated_with ;
    skos:definition "A relationship that holds between two concepts represented by variables for which a statistical correlation  is demonstrated, wherein variable values move in opposite directions (i.e. increased in one or presence of  one correlates with a decrease or absence of the other)." ;
    skos:exactMatch CTD:negative_correlation ;
    biolink:canonical_predicate "True" ;
    biolink:opposite_of "positively correlated with" .

biolink:object_location_in_text a owl:ObjectProperty ;
    rdfs:label "object location in text" ;
    rdfs:domain biolink:Association ;
    rdfs:range linkml:Integer ;
    rdfs:subPropertyOf biolink:association_slot ;
    skos:definition "Character offsets for the text span(s) in the supporting text corresponding to the object concept of the extracted assertion" ;
    linkml:examples "Example(value='15', description=None)" .

biolink:occurs_together_in_literature_with a owl:ObjectProperty,
        owl:SymmetricProperty ;
    rdfs:label "occurs together in literature with" ;
    rdfs:domain biolink:NamedThing ;
    rdfs:range biolink:NamedThing ;
    rdfs:subPropertyOf biolink:correlated_with ;
    skos:definition "holds between two entities where their co-occurrence is correlated by counts of publications in which both occur, using some threshold of occurrence as defined by the edge provider." ;
    biolink:canonical_predicate "True" .

biolink:opposite_of a owl:ObjectProperty,
        owl:SymmetricProperty ;
    rdfs:label "opposite of" ;
    rdfs:domain biolink:NamedThing ;
    rdfs:range biolink:NamedThing ;
    rdfs:seeAlso "https://doi.org/10.1101/108977",
        "https://github.com/biolink/biolink-model/issues/657" ;
    rdfs:subPropertyOf biolink:related_to_at_instance_level ;
    skos:definition "x is the opposite of y if there exists some distance metric M, and there exists no z such as M(x,z) <= M(x,y) or M(y,z) <= M(y,x). (This description is from RO. Needs to be rephrased)." ;
    skos:exactMatch RO:0002604 ;
    biolink:canonical_predicate "True" .

biolink:orthologous_to a owl:ObjectProperty,
        owl:SymmetricProperty ;
    rdfs:label "orthologous to" ;
    rdfs:domain biolink:NamedThing ;
    rdfs:range biolink:NamedThing ;
    rdfs:subPropertyOf biolink:homologous_to ;
    skos:definition "a homology relationship between entities (typically genes) that diverged after a speciation event." ;
    skos:exactMatch RO:HOM0000017,
        WIKIDATA_PROPERTY:P684 ;
    biolink:canonical_predicate "True" .

biolink:paralogous_to a owl:ObjectProperty,
        owl:SymmetricProperty ;
    rdfs:label "paralogous to" ;
    rdfs:domain biolink:NamedThing ;
    rdfs:range biolink:NamedThing ;
    rdfs:subPropertyOf biolink:homologous_to ;
    skos:definition "a homology relationship that holds between entities (typically genes) that diverged after a duplication event." ;
    skos:exactMatch RO:HOM0000011 ;
    biolink:canonical_predicate "True" .

biolink:positively_correlated_with a owl:ObjectProperty,
        owl:SymmetricProperty ;
    rdfs:label "positively correlated with" ;
    rdfs:domain biolink:NamedThing ;
    rdfs:range biolink:NamedThing ;
    rdfs:subPropertyOf biolink:correlated_with ;
    skos:definition "A relationship that holds between two concepts represented by variables for which a statistical correlation  is demonstrated, wherein variable values move together in the same direction (i.e. increased in one or  presence of one correlates with an increase or presence of the other)." ;
    skos:exactMatch CTD:positive_correlation ;
    biolink:canonical_predicate "True" ;
    biolink:opposite_of "negatively correlated with" .

biolink:reaction_balanced a owl:ObjectProperty ;
    rdfs:label "reaction balanced" ;
    rdfs:domain biolink:Association ;
    rdfs:range linkml:Boolean ;
    rdfs:subPropertyOf biolink:association_slot .

biolink:related_condition a owl:ObjectProperty,
        owl:SymmetricProperty ;
    rdfs:label "related condition" ;
    rdfs:domain biolink:NamedThing ;
    rdfs:range biolink:NamedThing ;
    rdfs:subPropertyOf biolink:related_to_at_instance_level ;
    skos:exactMatch <http://purl.obolibrary.org/obo/GENO_0000790> ;
    biolink:canonical_predicate "True" .

biolink:related_synonym a owl:ObjectProperty ;
    rdfs:label "related synonym" ;
    rdfs:domain biolink:NamedThing ;
    rdfs:range biolink:LabelType ;
    rdfs:subPropertyOf biolink:synonym ;
    skos:exactMatch oboformat:hasRelatedSynonym .

biolink:relation a owl:ObjectProperty ;
    rdfs:label "relation" ;
    rdfs:range linkml:String .

biolink:relative_frequency_object a owl:ObjectProperty ;
    rdfs:label "relative frequency object" ;
    rdfs:domain biolink:Association ;
    rdfs:range linkml:String ;
    rdfs:subPropertyOf biolink:association_slot ;
    skos:definition "The frequency at which subject and object concepts co-occur in  records within a dataset/cohort, relative to the frequency at which the object concept appears in these same records." .

biolink:relative_frequency_object_confidence_interval a owl:ObjectProperty ;
    rdfs:label "relative frequency object confidence interval" ;
    rdfs:domain biolink:Association ;
    rdfs:range linkml:String ;
    rdfs:subPropertyOf biolink:association_slot ;
    skos:definition "The 99% confidence interval for the relative_frequency_object calculation (i.e. the range of values within which the true value has a 99% chance of falling)" .

biolink:relative_frequency_subject a owl:ObjectProperty ;
    rdfs:label "relative frequency subject" ;
    rdfs:domain biolink:Association ;
    rdfs:range linkml:Float ;
    rdfs:subPropertyOf biolink:association_slot ;
    skos:definition "The frequency at which subject and object concepts co-occur in  records within a dataset/cohort, relative to the frequency at which the subject concept appears in these same records." ;
    linkml:examples "Example(value='0.01840490798', description=None)" .

biolink:relative_frequency_subject_confidence_interval a owl:ObjectProperty ;
    rdfs:label "relative frequency subject confidence interval" ;
    rdfs:domain biolink:Association ;
    rdfs:range linkml:String ;
    rdfs:subPropertyOf biolink:association_slot ;
    skos:definition "The 99% confidence interval for the relative_frequency_subject calculation (i.e. the range of values within which the true value has a 99% chance of falling)" .

biolink:retrieved_on a owl:ObjectProperty ;
    rdfs:label "retrieved on" ;
    rdfs:domain biolink:Dataset ;
    rdfs:range linkml:Date ;
    rdfs:subPropertyOf biolink:node_property ;
    skos:exactMatch pav:retrievedOn .

biolink:same_as a owl:ObjectProperty,
        owl:SymmetricProperty ;
    rdfs:label "same as" ;
    rdfs:domain biolink:NamedThing ;
    rdfs:range biolink:NamedThing ;
    rdfs:subPropertyOf biolink:exact_match ;
    skos:closeMatch owl:equivalentClass ;
    skos:definition "holds between two entities that are considered equivalent to each other" ;
    skos:exactMatch <http://purl.obolibrary.org/obo/MONDO_equivalentTo>,
        owl:sameAs,
        skos:exactMatch,
        CHEMBL.MECHANISM:equivalent_to,
        WIKIDATA_PROPERTY:P2888 ;
    skos:narrowMatch <http://identifiers.org/drugbank/external-identifier> ;
    biolink:canonical_predicate "True" .

biolink:sequence_variant_qualifier a owl:ObjectProperty ;
    rdfs:label "sequence variant qualifier" ;
    rdfs:domain biolink:Association ;
    rdfs:range biolink:SequenceVariant ;
    rdfs:subPropertyOf biolink:association_slot ;
    skos:definition "a qualifier used in an association with the variant" .

biolink:start_coordinate a owl:ObjectProperty ;
    rdfs:label "start coordinate" ;
    rdfs:domain biolink:GenomicSequenceLocalization ;
    rdfs:range linkml:Integer ;
    rdfs:subPropertyOf biolink:base_coordinate ;
    skos:altLabel "start" ;
    skos:closeMatch <http://biohackathon.org/resource/faldo#begin> ;
    skos:definition "The position at which the subject genomic entity starts on the chromosome or other entity to which it is located on. (ie: the start of the sequence being referenced is 1)." ;
    skos:exactMatch gff3:start .

biolink:subclass_of a owl:ObjectProperty ;
    rdfs:label "subclass of" ;
    rdfs:domain biolink:OntologyClass ;
    rdfs:range biolink:OntologyClass ;
    rdfs:subPropertyOf biolink:related_to_at_concept_level ;
    skos:closeMatch LOINC:class_of,
        LOINC:has_class ;
    skos:definition "holds between two classes where the domain class is a specialization of the range class" ;
    skos:exactMatch MESH:isa,
        RXNORM:isa,
        <http://purl.obolibrary.org/obo/GO_isa>,
        rdfs:subClassOf,
        SEMMEDDB:ISA,
        CHEMBL.MECHANISM:subset_of,
        VANDF:isa,
        WIKIDATA_PROPERTY:P279 ;
    skos:narrowMatch LOINC:has_archetype,
        LOINC:has_parent_group,
        LOINC:is_presence_guidance_for,
        NDDF:has_dose_form,
        RXNORM:has_dose_form,
        RXNORM:has_doseformgroup,
        <http://purl.obolibrary.org/obo/CHEBI_has_parent_hydride>,
        <http://purl.obolibrary.org/obo/NCIT_A11>,
        <http://purl.obolibrary.org/obo/NCIT_A14>,
        <http://purl.obolibrary.org/obo/NCIT_A16>,
        <http://purl.obolibrary.org/obo/NCIT_A3>,
        <http://purl.obolibrary.org/obo/NCIT_R36>,
        <http://purl.obolibrary.org/obo/NCIT_R42>,
        <http://purl.obolibrary.org/obo/NCIT_gene_product_has_chemical_classification>,
        <http://purl.obolibrary.org/obo/SNOMED_entire_anatomy_structure_of>,
        <http://purl.obolibrary.org/obo/SNOMED_has_dose_form>,
        rdfs:subPropertyOf ;
    biolink:canonical_predicate "True" .

biolink:subject_location_in_text a owl:ObjectProperty ;
    rdfs:label "subject location in text" ;
    rdfs:domain biolink:Association ;
    rdfs:range linkml:Integer ;
    rdfs:subPropertyOf biolink:association_slot ;
    skos:definition "Character offsets for the text span(s) in the supporting text corresponding to the subject concept of the extracted assertion." ;
    linkml:examples "Example(value='15', description=None)" .

biolink:superclass_of a owl:ObjectProperty ;
    rdfs:label "superclass of" ;
    rdfs:domain biolink:OntologyClass ;
    rdfs:range biolink:OntologyClass ;
    rdfs:subPropertyOf biolink:related_to_at_concept_level ;
    skos:definition "holds between two classes where the domain class is a super class of the range class" ;
    skos:exactMatch MESH:inverse_isa,
        RXNORM:inverse_isa,
        <http://purl.obolibrary.org/obo/GO_inverse_isa>,
        CHEMBL.MECHANISM:superset_of,
        VANDF:inverse_isa,
        WIKIDATA:Q66088480 ;
    skos:narrowMatch <http://identifiers.org/umls/RB>,
        <http://purl.obolibrary.org/obo/NCIT_cdrh_parent_of>,
        <http://purl.obolibrary.org/obo/NCIT_ctcae_5_parent_of>,
        <http://purl.obolibrary.org/obo/NCIT_subset_includes_concept>,
        <http://purl.obolibrary.org/obo/OMIM_has_manifestation>,
        <http://purl.obolibrary.org/obo/SNOMED_has_basic_dose_form> .

biolink:supporting_data_set a owl:ObjectProperty ;
    rdfs:label "supporting data set" ;
    rdfs:domain biolink:Association ;
    rdfs:range biolink:InformationResource ;
    rdfs:subPropertyOf biolink:association_slot ;
    skos:definition "A set of data used as evidence to generate the knowledge expressed in an Association (e.g. through computation on, reasoning or inference over the retrieved data)." .

biolink:supporting_data_source a owl:ObjectProperty ;
    rdfs:label "supporting data source" ;
    rdfs:domain biolink:Association ;
    rdfs:range biolink:InformationResource ;
    rdfs:subPropertyOf biolink:association_slot ;
    skos:definition "An Information Resource from which data was retrieved and subsequently used as evidence to generate the knowledge expressed in an Association (e.g. through computation on, reasoning or inference over the retrieved data)." ;
    skos:editorialNote "For example, in this Feature Variable Association Edge generated by the Exposure Agent’s ICEES KP,  through statistical analysis of clinical and environmental data supplied by the UNC Clinical Data Warehouse,  the Edge is passed to the Ranking Agent’s ARAGORN ARA,  and then on to the ARS. The retrieval path for this Edge is as follows: ARS--retrieved_from-->  ARAGORN  --retrieved_from-->   ICEES --supporting_data_from-->  UNC Data Warehouse This example illustrates how to represent the source provenance of KP-generated knowledge, including the source of  data from which the knowledge was derived.    The \"primary knowledge source\" for this edge is \"infores:icees-asthma\". A \"supporting data source\" for this KP- generated knowledge is \"infores:unc-cdw-health.\"  The \"aggregator knowledge source\" for this data is \"infores:aragorn-ara\"" .

biolink:supporting_document_type a owl:ObjectProperty ;
    rdfs:label "supporting document type" ;
    rdfs:domain biolink:Association ;
    rdfs:range linkml:String ;
    rdfs:subPropertyOf biolink:association_slot ;
    skos:definition "The document type (e.g., Journal Article, Case Study, Preprint) for the supporting document used in a Text Mining Result." ;
    linkml:examples "Example(value='Journal Article', description=None)" .

biolink:supporting_document_year a owl:ObjectProperty ;
    rdfs:label "supporting document year" ;
    rdfs:domain biolink:Association ;
    rdfs:range linkml:Integer ;
    rdfs:subPropertyOf biolink:association_slot ;
    skos:definition "The document year (typically the publication year) for the supporting document used in a Text Mining Result." ;
    linkml:examples "Example(value='1999', description=None)" .

biolink:supporting_study_cohort a owl:ObjectProperty ;
    rdfs:label "supporting study cohort" ;
    rdfs:domain biolink:Association ;
    rdfs:range linkml:String ;
    rdfs:subPropertyOf biolink:supporting_study_metadata ;
    skos:definition "A description of a study population/cohort that was interrogated to provide evidence for the association  (e.g. the inclusion and exclusion criteria)." .

biolink:supporting_study_context a owl:ObjectProperty ;
    rdfs:label "supporting study context" ;
    rdfs:domain biolink:Association ;
    rdfs:range linkml:String ;
    rdfs:subPropertyOf biolink:supporting_study_metadata ;
    skos:definition "A term or terms describing the experimental setting/context in which evidence supporting the Association was  generated ('context' may be defined by many factors, including taxon, model system (e.g. cell line type), tissue  type, disease, etc.)." .

biolink:supporting_study_date_range a owl:ObjectProperty ;
    rdfs:label "supporting study date range" ;
    rdfs:domain biolink:Association ;
    rdfs:range linkml:String ;
    rdfs:subPropertyOf biolink:supporting_study_metadata ;
    skos:definition "The date range over which data was collected in a study that provided evidence for an Association." .

biolink:supporting_study_method_description a owl:ObjectProperty ;
    rdfs:label "supporting study method description" ;
    rdfs:domain biolink:Association ;
    rdfs:range linkml:Uriorcurie ;
    rdfs:subPropertyOf biolink:supporting_study_metadata ;
    skos:definition "A uri or curie pointing to information about the methodology used to generate data supporting an Association." .

biolink:supporting_study_method_type a owl:ObjectProperty ;
    rdfs:label "supporting study method type" ;
    rdfs:domain biolink:Association ;
    rdfs:range linkml:Uriorcurie ;
    rdfs:subPropertyOf biolink:supporting_study_metadata ;
    skos:definition "A type of method that was applied in a study used to generate the information used as evidence (e.g. a type of  experimental assay, or statistical calculation, or computational analysis)." .

biolink:supporting_study_size a owl:ObjectProperty ;
    rdfs:label "supporting study size" ;
    rdfs:domain biolink:Association ;
    rdfs:range linkml:Integer ;
    rdfs:subPropertyOf biolink:supporting_study_metadata ;
    skos:definition "The sample size used in a study that provided evidence for the association (e.g. 'n' of a cohort for a  clinical study)." .

biolink:supporting_text a owl:ObjectProperty ;
    rdfs:label "supporting text" ;
    rdfs:domain biolink:Association ;
    rdfs:range linkml:String ;
    rdfs:subPropertyOf biolink:association_slot ;
    skos:definition "The segment of text from a document that supports the mined assertion." ;
    linkml:examples "Example(value='The administration of 50g/ml bupivacaine promoted maximum breast cancer.', description=None)" .

biolink:supporting_text_section_type a owl:ObjectProperty ;
    rdfs:label "supporting text section type" ;
    rdfs:domain biolink:Association ;
    rdfs:range linkml:String ;
    rdfs:subPropertyOf biolink:association_slot ;
    skos:definition "The section of the supporting text of a Text Mining Result within the supporting document. This is in the form of the name of the document section (e.g., Abstract, Introduction) that contains the supporting text." ;
    linkml:examples "Example(value='Introduction', description=None)" .

biolink:temporal_interval_qualifier a owl:ObjectProperty ;
    rdfs:label "temporal interval qualifier" ;
    rdfs:domain biolink:Association ;
    rdfs:range biolink:TimeType ;
    rdfs:subPropertyOf biolink:temporal_context_qualifier ;
    skos:definition "a constraint of a time interval placed upon the truth value of an association." .

biolink:update_date a owl:ObjectProperty ;
    rdfs:label "update date" ;
    rdfs:domain biolink:NamedThing ;
    rdfs:range linkml:Date ;
    rdfs:subPropertyOf biolink:node_property ;
    skos:definition "date on which an entity was updated. This can be applied to nodes or edges" .

biolink:version a owl:ObjectProperty ;
    rdfs:label "version" ;
    rdfs:domain biolink:Dataset ;
    rdfs:range linkml:String ;
    rdfs:subPropertyOf biolink:node_property ;
    skos:broadMatch pav:version,
        owl:versionInfo .

biolink:version_of a owl:ObjectProperty ;
    rdfs:label "version of" ;
    rdfs:domain biolink:DatasetVersion ;
    rdfs:range biolink:DatasetSummary ;
    rdfs:subPropertyOf biolink:node_property ;
    skos:exactMatch dct:isVersionOf .

biolink:xenologous_to a owl:ObjectProperty,
        owl:SymmetricProperty ;
    rdfs:label "xenologous to" ;
    rdfs:domain biolink:NamedThing ;
    rdfs:range biolink:NamedThing ;
    rdfs:subPropertyOf biolink:homologous_to ;
    skos:definition "a homology relationship characterized by an interspecies (horizontal) transfer since the common ancestor." ;
    skos:exactMatch RO:HOM0000018 ;
    biolink:canonical_predicate "True" .

GOP:systematic_synonym a owl:ObjectProperty ;
    rdfs:label "systematic synonym" ;
    rdfs:domain biolink:NamedThing ;
    rdfs:range biolink:LabelType ;
    rdfs:subPropertyOf biolink:node_property ;
    skos:definition "more commonly used for gene symbols in yeast" ;
    skos:exactMatch GOP:systematic_synonym .

dcat:downloadURL a owl:ObjectProperty .

biolink:AdministrativeEntity a owl:Class ;
    rdfs:label "administrative entity" ;
    rdfs:subClassOf biolink:NamedThing .

biolink:Behavior a owl:Class ;
    rdfs:label "behavior" ;
    rdfs:subClassOf biolink:ActivityAndBehavior,
        biolink:BiologicalProcess,
        biolink:OntologyClass ;
    skos:exactMatch STY:T053,
        <http://purl.obolibrary.org/obo/GO_0007610> ;
    skos:narrowMatch STY:T041,
        STY:T054,
        STY:T055 .

biolink:BehavioralFeature a owl:Class ;
    rdfs:label "behavioral feature" ;
    rdfs:subClassOf biolink:PhenotypicFeature ;
    skos:definition "A phenotypic feature which is behavioral in nature." ;
    skos:exactMatch <http://purl.obolibrary.org/obo/NBO_0000243> .

biolink:BookChapter a owl:Class ;
    rdfs:label "book chapter" ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:maxQualifiedCardinality 1 ;
            owl:onClass linkml:String ;
            owl:onProperty biolink:volume ],
        [ a owl:Restriction ;
            owl:onClass linkml:Uriorcurie ;
            owl:onProperty biolink:published_in ;
            owl:qualifiedCardinality 1 ],
        [ a owl:Restriction ;
            owl:maxQualifiedCardinality 1 ;
            owl:onClass linkml:String ;
            owl:onProperty biolink:chapter ],
        biolink:Publication .

biolink:Case a owl:Class ;
    rdfs:label "case" ;
    rdfs:subClassOf biolink:IndividualOrganism,
        biolink:SubjectOfInvestigation ;
    skos:altLabel "patient",
        "proband" ;
    skos:definition "An individual (human) organism that has a patient role in some clinical context." .

biolink:CellLineToDiseaseOrPhenotypicFeatureAssociation a owl:Class ;
    rdfs:label "cell line to disease or phenotypic feature association" ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:onClass biolink:DiseaseOrPhenotypicFeature ;
            owl:onProperty rdf:subject ;
            owl:qualifiedCardinality 1 ],
        biolink:Association,
        biolink:CellLineToEntityAssociationMixin,
        biolink:EntityToDiseaseOrPhenotypicFeatureAssociationMixin ;
    skos:definition "An relationship between a cell line and a disease or a phenotype, where the cell line is derived from an individual with that disease or phenotype." .

biolink:ChemicalExposure a owl:Class ;
    rdfs:label "chemical exposure" ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:maxQualifiedCardinality 1 ;
            owl:onClass biolink:TimeType ;
            owl:onProperty biolink:timepoint ],
        biolink:Attribute,
        biolink:ExposureEvent ;
    skos:definition "A chemical exposure is an intake of a particular chemical entity." ;
    skos:exactMatch ECTO:9000000,
        SIO:001399 .

biolink:ChemicalFormulaValue a owl:Class ;
    rdfs:label "chemical formula value" ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:onDataRange xsd:string ;
            owl:onProperty linkml:topValue ;
            owl:qualifiedCardinality 1 ] ;
    skos:editorialNote "Should be implemented as a stronger type" .

biolink:ChemicalOrDrugOrTreatmentToDiseaseOrPhenotypicFeatureAssociation a owl:Class ;
    rdfs:label "chemical or drug or treatment to disease or phenotypic feature association" ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:onClass biolink:PredicateType ;
            owl:onProperty rdf:predicate ;
            owl:qualifiedCardinality 1 ],
        [ a owl:Restriction ;
            owl:maxQualifiedCardinality 1 ;
            owl:onClass biolink:FDAIDAAdverseEventEnum ;
            owl:onProperty biolink:FDA_adverse_event_level ],
        biolink:Association,
        biolink:ChemicalToEntityAssociationMixin,
        biolink:EntityToDiseaseOrPhenotypicFeatureAssociationMixin ;
    skos:definition "This association defines a relationship between a chemical or treatment (or procedure) and a disease or phenotypic feature where the disesae or phenotypic feature is a secondary undesirable effect." .

biolink:ClinicalCourse a owl:Class ;
    rdfs:label "clinical course" ;
    rdfs:subClassOf biolink:ClinicalAttribute ;
    skos:definition "The course a disease typically takes from its onset, progression in time, and eventual resolution or death of the affected individual" ;
    skos:exactMatch <http://purl.obolibrary.org/obo/HP_0031797> .

biolink:ClinicalIntervention a owl:Class ;
    rdfs:label "clinical intervention" ;
    rdfs:subClassOf biolink:ClinicalEntity .

biolink:ClinicalModifier a owl:Class ;
    rdfs:label "clinical modifier" ;
    rdfs:subClassOf biolink:ClinicalAttribute ;
    skos:definition "Used to characterize and specify the phenotypic abnormalities defined in the phenotypic abnormality sub-ontology, with respect to severity, laterality, and other aspects" .

biolink:CodingSequence a owl:Class ;
    rdfs:label "coding sequence" ;
    rdfs:subClassOf biolink:NucleicAcidEntity ;
    skos:exactMatch <http://purl.obolibrary.org/obo/SO_0000316>,
        SIO:001390 .

biolink:ConfidenceLevel a owl:Class ;
    rdfs:label "confidence level" ;
    rdfs:subClassOf biolink:InformationContentEntity ;
    skos:closeMatch <http://purl.obolibrary.org/obo/SEPIO_0000167> ;
    skos:definition "Level of confidence in a statement" ;
    skos:exactMatch <http://purl.obolibrary.org/obo/CIO_0000028>,
        <http://purl.obolibrary.org/obo/SEPIO_0000187> .

biolink:DrugExposure a owl:Class ;
    rdfs:label "drug exposure" ;
    rdfs:subClassOf biolink:ChemicalExposure,
        biolink:ExposureEvent ;
    skos:altLabel "drug dose",
        "drug intake",
        "medication intake" ;
    skos:broadMatch SIO:001005 ;
    skos:definition "A drug exposure is an intake of a particular drug." ;
    skos:exactMatch ECTO:0000509 .

biolink:DrugToEntityAssociationMixin a owl:Class ;
    rdfs:label "drug to entity association mixin" ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:onClass biolink:Drug ;
            owl:onProperty rdf:subject ;
            owl:qualifiedCardinality 1 ],
        biolink:ChemicalEntityToEntityAssociationMixin,
        linkml:mixin ;
    skos:definition "An interaction between a drug and another entity" .

biolink:DruggableGeneCategoryEnum a owl:Class ;
    rdfs:label "DruggableGeneCategoryEnum" ;
    owl:unionOf ( <https://w3id.org/biolink/vocab/DruggableGeneCategoryEnum#tclin> <https://w3id.org/biolink/vocab/DruggableGeneCategoryEnum#tbio> <https://w3id.org/biolink/vocab/DruggableGeneCategoryEnum#tchem> <https://w3id.org/biolink/vocab/DruggableGeneCategoryEnum#tdark> ) ;
    linkml:permissible_values <https://w3id.org/biolink/vocab/DruggableGeneCategoryEnum#tbio>,
        <https://w3id.org/biolink/vocab/DruggableGeneCategoryEnum#tchem>,
        <https://w3id.org/biolink/vocab/DruggableGeneCategoryEnum#tclin>,
        <https://w3id.org/biolink/vocab/DruggableGeneCategoryEnum#tdark> .

biolink:EnvironmentalExposure a owl:Class ;
    rdfs:label "environmental exposure" ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:maxQualifiedCardinality 1 ;
            owl:onClass biolink:TimeType ;
            owl:onProperty biolink:timepoint ],
        biolink:Attribute,
        biolink:ExposureEvent ;
    skos:definition "A environmental exposure is a factor relating to abiotic processes in the environment including sunlight (UV-B), atmospheric (heat, cold, general pollution) and water-born contaminants." .

biolink:Exon a owl:Class ;
    rdfs:label "exon" ;
    rdfs:subClassOf biolink:NucleicAcidEntity ;
    skos:definition "A region of the transcript sequence within a gene which is not removed from the primary RNA transcript by RNA splicing." ;
    skos:exactMatch <http://purl.obolibrary.org/obo/SO_0000147>,
        SIO:010445,
        WIKIDATA:Q373027 .

biolink:FDA_adverse_event_level a owl:ObjectProperty ;
    rdfs:label "FDA adverse event level" ;
    rdfs:domain biolink:Association ;
    rdfs:range biolink:FDAIDAAdverseEventEnum ;
    rdfs:subPropertyOf biolink:association_slot ;
    skos:definition "" .

biolink:GeneFamily a owl:Class ;
    rdfs:label "gene family" ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:allValuesFrom biolink:Gene ;
            owl:onProperty biolink:has_gene_or_gene_product ],
        biolink:BiologicalEntity,
        biolink:ChemicalEntityOrGeneOrGeneProduct,
        biolink:GeneGroupingMixin ;
    skos:altLabel "orthogroup",
        "protein family" ;
    skos:definition "any grouping of multiple genes or gene products related by common descent" ;
    skos:exactMatch <http://purl.obolibrary.org/obo/NCIT_C26004>,
        WIKIDATA:Q2278983 ;
    skos:narrowMatch <http://purl.obolibrary.org/obo/NCIT_C20130>,
        SIO:001380,
        WIKIDATA:Q417841 .

biolink:GenotypeToDiseaseAssociation a owl:Class ;
    rdfs:label "genotype to disease association" ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:onClass biolink:NamedThing ;
            owl:onProperty rdf:object ;
            owl:qualifiedCardinality 1 ],
        [ a owl:Restriction ;
            owl:maxQualifiedCardinality 1 ;
            owl:onClass biolink:SeverityValue ;
            owl:onProperty biolink:severity_qualifier ],
        [ a owl:Restriction ;
            owl:maxQualifiedCardinality 1 ;
            owl:onClass biolink:Onset ;
            owl:onProperty biolink:onset_qualifier ],
        [ a owl:Restriction ;
            owl:onClass biolink:NamedThing ;
            owl:onProperty rdf:subject ;
            owl:qualifiedCardinality 1 ],
        [ a owl:Restriction ;
            owl:onClass biolink:PredicateType ;
            owl:onProperty rdf:predicate ;
            owl:qualifiedCardinality 1 ],
        [ a owl:Restriction ;
            owl:maxQualifiedCardinality 1 ;
            owl:onClass biolink:FrequencyValue ;
            owl:onProperty biolink:frequency_qualifier ],
        biolink:Association,
        biolink:EntityToDiseaseAssociationMixin,
        biolink:GenotypeToEntityAssociationMixin ;
    skos:note "TODO decide no how to model pathogenicity" .

biolink:GeographicLocation a owl:Class ;
    rdfs:label "geographic location" ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:maxQualifiedCardinality 1 ;
            owl:onClass linkml:Float ;
            owl:onProperty biolink:longitude ],
        [ a owl:Restriction ;
            owl:maxQualifiedCardinality 1 ;
            owl:onClass linkml:Float ;
            owl:onProperty biolink:latitude ],
        biolink:PlanetaryEntity ;
    skos:definition "a location that can be described in lat/long coordinates" ;
    skos:exactMatch STY:T083,
        UMLSSG:GEOG .

biolink:LogicalInterpretationEnum a owl:Class ;
    rdfs:label "LogicalInterpretationEnum" ;
    owl:unionOf ( os:SomeSomeInterpretation os:AllSomeInterpretation <https://w3id.org/biolink/vocab/LogicalInterpretationEnum#inverse_all_some> ) ;
    linkml:permissible_values os:AllSomeInterpretation,
        os:SomeSomeInterpretation,
        <https://w3id.org/biolink/vocab/LogicalInterpretationEnum#inverse_all_some> .

biolink:MappingCollection a owl:Class ;
    rdfs:label "mapping collection" ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:allValuesFrom biolink:PredicateMapping ;
            owl:onProperty biolink:predicate_mappings ] ;
    skos:definition "A collection of deprecated mappings." .

biolink:MolecularMixture a owl:Class ;
    rdfs:label "molecular mixture" ;
    rdfs:subClassOf biolink:ChemicalMixture ;
    skos:definition "A molecular mixture is a chemical mixture composed of two or more molecular entities with known concentration and stoichiometry." .

biolink:OrganismAttribute a owl:Class ;
    rdfs:label "organism attribute" ;
    rdfs:subClassOf biolink:Attribute ;
    skos:definition "describes a characteristic of an organismal entity." ;
    skos:exactMatch STY:T032 .

biolink:PairwiseGeneToGeneInteraction a owl:Class ;
    rdfs:label "pairwise gene to gene interaction" ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:onClass biolink:PredicateType ;
            owl:onProperty rdf:predicate ;
            owl:qualifiedCardinality 1 ],
        biolink:GeneToGeneAssociation ;
    skos:definition "An interaction between two genes or two gene products. May be physical (e.g. protein binding) or genetic (between genes). May be symmetric (e.g. protein interaction) or directed (e.g. phosphorylation)" ;
    skos:narrowMatch dcid:ProteinProteinInteraction .

biolink:Polypeptide a owl:Class ;
    rdfs:label "polypeptide" ;
    rdfs:subClassOf biolink:BiologicalEntity,
        biolink:ChemicalEntityOrGeneOrGeneProduct,
        biolink:ChemicalEntityOrProteinOrPolypeptide ;
    skos:altLabel "amino acid entity" ;
    skos:definition "A polypeptide is a molecular entity characterized by availability in protein databases of amino-acid-based sequence representations of its precise primary structure; for convenience of representation, partial sequences of various kinds are included, even if they do not represent a physical molecule." ;
    skos:narrowMatch STY:T087,
        STY:T116,
        <http://purl.obolibrary.org/obo/SO_0000104> .

biolink:ReactionToParticipantAssociation a owl:Class ;
    rdfs:label "reaction to participant association" ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:maxQualifiedCardinality 1 ;
            owl:onClass biolink:ReactionDirectionEnum ;
            owl:onProperty biolink:reaction_direction ],
        [ a owl:Restriction ;
            owl:maxQualifiedCardinality 1 ;
            owl:onClass linkml:Integer ;
            owl:onProperty biolink:stoichiometry ],
        [ a owl:Restriction ;
            owl:onClass biolink:MolecularEntity ;
            owl:onProperty rdf:subject ;
            owl:qualifiedCardinality 1 ],
        [ a owl:Restriction ;
            owl:maxQualifiedCardinality 1 ;
            owl:onClass biolink:ReactionSideEnum ;
            owl:onProperty biolink:reaction_side ],
        biolink:ChemicalToChemicalAssociation .

biolink:SequenceAssociation a owl:Class ;
    rdfs:label "sequence association" ;
    rdfs:subClassOf biolink:Association ;
    skos:definition "An association between a sequence feature and a nucleic acid entity it is localized to." .

biolink:SpecificityQuantifier a owl:Class ;
    rdfs:label "specificity quantifier" ;
    rdfs:subClassOf biolink:RelationshipQuantifier,
        linkml:mixin .

biolink:StudyPopulation a owl:Class ;
    rdfs:label "study population" ;
    rdfs:subClassOf biolink:PopulationOfIndividualOrganisms ;
    skos:closeMatch WIKIDATA:Q7229825 ;
    skos:definition "A group of people banded together or treated as a group as participants in a research study." .

biolink:SymbolType a owl:Class ;
    rdfs:label "symbol type" ;
    rdfs:subClassOf linkml:String .

biolink:Treatment a owl:Class ;
    rdfs:label "treatment" ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:maxQualifiedCardinality 1 ;
            owl:onClass biolink:TimeType ;
            owl:onProperty biolink:timepoint ],
        [ a owl:Restriction ;
            owl:allValuesFrom biolink:Drug ;
            owl:onProperty biolink:has_drug ],
        [ a owl:Restriction ;
            owl:allValuesFrom biolink:Device ;
            owl:onProperty biolink:has_device ],
        [ a owl:Restriction ;
            owl:allValuesFrom biolink:Procedure ;
            owl:onProperty biolink:has_procedure ],
        biolink:ChemicalOrDrugOrTreatment,
        biolink:ExposureEvent,
        biolink:NamedThing ;
    skos:altLabel "medical action",
        "medical intervention" ;
    skos:broadMatch MAXO:0000058 ;
    skos:definition "A treatment is targeted at a disease or phenotype and may involve multiple drug 'exposures', medical devices and/or procedures" ;
    skos:exactMatch <http://purl.obolibrary.org/obo/OGMS_0000090>,
        SIO:001398 .

biolink:VariantToDiseaseAssociation a owl:Class ;
    rdfs:label "variant to disease association" ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:maxQualifiedCardinality 1 ;
            owl:onClass biolink:SeverityValue ;
            owl:onProperty biolink:severity_qualifier ],
        [ a owl:Restriction ;
            owl:maxQualifiedCardinality 1 ;
            owl:onClass biolink:Onset ;
            owl:onProperty biolink:onset_qualifier ],
        [ a owl:Restriction ;
            owl:onClass biolink:NamedThing ;
            owl:onProperty rdf:object ;
            owl:qualifiedCardinality 1 ],
        [ a owl:Restriction ;
            owl:onClass biolink:NamedThing ;
            owl:onProperty rdf:subject ;
            owl:qualifiedCardinality 1 ],
        [ a owl:Restriction ;
            owl:onClass biolink:PredicateType ;
            owl:onProperty rdf:predicate ;
            owl:qualifiedCardinality 1 ],
        [ a owl:Restriction ;
            owl:maxQualifiedCardinality 1 ;
            owl:onClass biolink:FrequencyValue ;
            owl:onProperty biolink:frequency_qualifier ],
        biolink:Association,
        biolink:EntityToDiseaseAssociationMixin,
        biolink:VariantToEntityAssociationMixin ;
    skos:note "TODO decide no how to model pathogenicity" .

biolink:VariantToGeneAssociation a owl:Class ;
    rdfs:label "variant to gene association" ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:onClass biolink:PredicateType ;
            owl:onProperty rdf:predicate ;
            owl:qualifiedCardinality 1 ],
        [ a owl:Restriction ;
            owl:onClass biolink:Gene ;
            owl:onProperty rdf:object ;
            owl:qualifiedCardinality 1 ],
        biolink:Association,
        biolink:VariantToEntityAssociationMixin ;
    skos:definition "An association between a variant and a gene, where the variant has a genetic association with the gene (i.e. is in linkage disequilibrium)" .

biolink:active_in a owl:ObjectProperty ;
    rdfs:label "active in" ;
    rdfs:domain biolink:GeneOrGeneProduct ;
    rdfs:range biolink:CellularComponent ;
    rdfs:subPropertyOf biolink:related_to_at_instance_level ;
    owl:inverseOf biolink:has_active_component ;
    skos:exactMatch RO:0002432 ;
    biolink:canonical_predicate "True" .

biolink:acts_upstream_of_negative_effect a owl:ObjectProperty ;
    rdfs:label "acts upstream of negative effect" ;
    rdfs:domain biolink:GeneOrGeneProduct ;
    rdfs:range biolink:BiologicalProcess ;
    rdfs:subPropertyOf biolink:acts_upstream_of ;
    owl:inverseOf biolink:has_negative_upstream_actor ;
    skos:exactMatch RO:0004035 ;
    biolink:canonical_predicate "True" .

biolink:acts_upstream_of_or_within_negative_effect a owl:ObjectProperty ;
    rdfs:label "acts upstream of or within negative effect" ;
    rdfs:domain biolink:GeneOrGeneProduct ;
    rdfs:range biolink:BiologicalProcess ;
    rdfs:subPropertyOf biolink:acts_upstream_of_or_within ;
    owl:inverseOf biolink:has_negative_upstream_or_within_actor ;
    skos:exactMatch RO:0004033 ;
    biolink:canonical_predicate "True" .

biolink:acts_upstream_of_or_within_positive_effect a owl:ObjectProperty ;
    rdfs:label "acts upstream of or within positive effect" ;
    rdfs:domain biolink:GeneOrGeneProduct ;
    rdfs:range biolink:BiologicalProcess ;
    rdfs:subPropertyOf biolink:acts_upstream_of_or_within ;
    owl:inverseOf biolink:has_positive_upstream_or_within_actor ;
    skos:exactMatch RO:0004032 ;
    biolink:canonical_predicate "True" .

biolink:acts_upstream_of_positive_effect a owl:ObjectProperty ;
    rdfs:label "acts upstream of positive effect" ;
    rdfs:domain biolink:GeneOrGeneProduct ;
    rdfs:range biolink:BiologicalProcess ;
    rdfs:subPropertyOf biolink:acts_upstream_of ;
    owl:inverseOf biolink:has_positive_upstream_actor ;
    skos:exactMatch RO:0004034 ;
    biolink:canonical_predicate "True" .

biolink:address a owl:ObjectProperty ;
    rdfs:label "address" ;
    rdfs:domain biolink:NamedThing ;
    rdfs:range linkml:String ;
    rdfs:subPropertyOf biolink:node_property ;
    skos:definition "the particulars of the place where someone or an organization is situated.  For now, this slot is a simple text \"blob\" containing all relevant details of the given location for fitness of purpose. For the moment, this \"address\" can include other contact details such as email and phone number(?)." .

biolink:adjusted_p_value a owl:ObjectProperty ;
    rdfs:label "adjusted p value" ;
    rdfs:domain biolink:Association ;
    rdfs:range linkml:Float ;
    rdfs:subPropertyOf biolink:p_value ;
    skos:definition "The adjusted p-value is the probability of obtaining test results at least as extreme as the results actually observed, under the assumption that the null hypothesis is correct, adjusted for multiple comparisons.   P is always italicized and capitalized. The actual P value* should be expressed (P=. 04)  rather than expressing a statement of inequality (P<. 05), unless P<." .

biolink:adverse_event_of a owl:ObjectProperty ;
    rdfs:label "adverse event of" ;
    rdfs:domain biolink:DiseaseOrPhenotypicFeature ;
    rdfs:range biolink:ChemicalOrDrugOrTreatment ;
    rdfs:subPropertyOf biolink:affected_by ;
    owl:inverseOf biolink:has_adverse_event .

biolink:affiliation a owl:ObjectProperty ;
    rdfs:label "affiliation" ;
    rdfs:domain biolink:Agent ;
    rdfs:range linkml:Uriorcurie ;
    rdfs:subPropertyOf biolink:node_property ;
    skos:definition "a professional relationship between one provider (often a person) within another provider (often an organization). Target provider identity should be specified by a CURIE. Providers may have multiple affiliations." .

biolink:aggregator_knowledge_source a owl:ObjectProperty ;
    rdfs:label "aggregator knowledge source" ;
    rdfs:domain biolink:Association ;
    rdfs:range biolink:InformationResource ;
    rdfs:subPropertyOf biolink:knowledge_source ;
    skos:definition "An intermediate aggregator resource from which knowledge expressed in an Association was retrieved downstream of the original source, on its path to its current serialized form." ;
    skos:editorialNote "For example, in this Feature Variable Association Edge generated by the Exposure Agent’s ICEES KP,  through statistical analysis of clinical and environmental data supplied by the UNC Clinical Data Warehouse,  the Edge is passed to the Ranking Agent’s ARAGORN ARA,  and then on to the ARS. The retrieval path for this Edge is as follows: ARS--retrieved_from-->  ARAGORN  --retrieved_from-->   ICEES --supporting_data_from-->  UNC Data Warehouse This example illustrates how to represent the source provenance of KP-generated knowledge, including the source of  data from which the knowledge was derived.    The \"primary knowledge source\" for this edge is \"infores:icees-asthma\". A \"supporting data source\" for this KP- generated knowledge is \"infores:unc-cdw-health.\"  The \"aggregator knowledge source\" for this data is \"infores:aragorn-ara\"" .

biolink:amount_or_activity_decreased_by a owl:ObjectProperty ;
    rdfs:label "amount or activity decreased by" ;
    rdfs:domain biolink:NamedThing ;
    rdfs:range biolink:NamedThing ;
    rdfs:subPropertyOf biolink:related_to_at_instance_level ;
    owl:inverseOf biolink:decreases_amount_or_activity_of .

biolink:amount_or_activity_increased_by a owl:ObjectProperty ;
    rdfs:label "amount or activity increased by" ;
    rdfs:domain biolink:NamedThing ;
    rdfs:range biolink:NamedThing ;
    rdfs:subPropertyOf biolink:related_to_at_instance_level ;
    owl:inverseOf biolink:increases_amount_or_activity_of .

biolink:assesses a owl:ObjectProperty ;
    rdfs:label "assesses" ;
    rdfs:domain biolink:NamedThing ;
    rdfs:range biolink:NamedThing ;
    rdfs:subPropertyOf biolink:related_to_at_instance_level ;
    owl:inverseOf biolink:is_assessed_by ;
    skos:altLabel "was assayed against" ;
    skos:definition "The effect of a thing on a target was interrogated in some assay. A relationship between some perturbing agent (usually a chemical compound) and some target entity, where the affect of the perturbing agent on the target entity was interrogated in a particular assay. The target might be a particular protein, tissue, phenotype, whole organism, cell line, or other type of biological entity." ;
    biolink:canonical_predicate "True" .

biolink:associated_environmental_context a owl:ObjectProperty ;
    rdfs:label "associated environmental context" ;
    rdfs:domain biolink:Association ;
    rdfs:range linkml:String ;
    rdfs:subPropertyOf biolink:association_slot ;
    skos:definition "An attribute that can be applied to an association where the association holds between two entities located or occurring in a particular environment. For example, two microbial taxa may interact in the context of a human gut; a disease may give rise to a particular phenotype in a particular environmental exposure. # TODO: add examples of values for this property." .

biolink:associated_with_decreased_likelihood_of a owl:ObjectProperty ;
    rdfs:label "associated with decreased likelihood of" ;
    rdfs:domain biolink:NamedThing ;
    rdfs:range biolink:NamedThing ;
    rdfs:subPropertyOf biolink:associated_with_likelihood_of ;
    owl:inverseOf biolink:decreased_likelihood_associated_with ;
    skos:definition "Expresses a relationship between two named things where the relationship is typically generated statistically and the state or fact of something is less probable." ;
    biolink:canonical_predicate "True" .

biolink:associated_with_increased_likelihood_of a owl:ObjectProperty ;
    rdfs:label "associated with increased likelihood of" ;
    rdfs:domain biolink:NamedThing ;
    rdfs:range biolink:NamedThing ;
    rdfs:subPropertyOf biolink:associated_with_likelihood_of ;
    owl:inverseOf biolink:increased_likelihood_associated_with ;
    skos:definition "Expresses a relationship between two named things where the relationship is typically generated statistically and the state or fact of something is more probable." ;
    biolink:canonical_predicate "True" .

biolink:associated_with_resistance_to a owl:ObjectProperty ;
    rdfs:label "associated with resistance to" ;
    rdfs:domain biolink:NamedThing ;
    rdfs:range biolink:ChemicalEntity ;
    rdfs:subPropertyOf biolink:associated_with ;
    owl:inverseOf biolink:resistance_associated_with ;
    skos:definition "A relation that holds between a named thing and a chemical that specifies that the change in the named thing is found to be associated with the degree of resistance to treatment by the chemical." ;
    biolink:canonical_predicate "True" .

biolink:associated_with_sensitivity_to a owl:ObjectProperty ;
    rdfs:label "associated with sensitivity to" ;
    rdfs:domain biolink:NamedThing ;
    rdfs:range biolink:ChemicalEntity ;
    rdfs:subPropertyOf biolink:associated_with ;
    owl:inverseOf biolink:sensitivity_associated_with ;
    skos:broadMatch <http://purl.obolibrary.org/obo/PATO_0000085> ;
    skos:definition "A relation that holds between a named thing and a chemical that specifies that the change in the named thing is found to be associated with the degree of sensitivity to treatment by the chemical." ;
    skos:narrowMatch SNOMEDCT:418038007 ;
    biolink:canonical_predicate "True" .

biolink:author a owl:ObjectProperty ;
    rdfs:label "author" ;
    rdfs:domain biolink:Agent ;
    rdfs:range biolink:Publication ;
    rdfs:subPropertyOf biolink:contributor ;
    owl:inverseOf biolink:has_author ;
    skos:definition "an instance of one (co-)creator primarily responsible for a written work" ;
    skos:exactMatch dct:creator,
        WIKIDATA_PROPERTY:P50 .

biolink:authors a owl:ObjectProperty ;
    rdfs:label "authors" ;
    rdfs:domain biolink:Publication ;
    rdfs:range linkml:String ;
    rdfs:subPropertyOf biolink:node_property ;
    skos:definition "connects an publication to the list of authors who contributed to the publication. This property should be a comma-delimited list of author names. It is recommended that an author's name be formatted as \"surname, firstname initial.\".   Note that this property is a node annotation expressing the citation list of authorship which might typically otherwise be more completely documented in biolink:PublicationToProviderAssociation defined edges which point to full details about an author and possibly, some qualifiers which clarify the specific status of a given author in the publication." .

biolink:available_from a owl:ObjectProperty ;
    rdfs:label "available from" ;
    rdfs:domain biolink:NamedThing ;
    rdfs:range biolink:DrugAvailabilityEnum ;
    rdfs:subPropertyOf biolink:node_property ;
    skos:definition "" .

biolink:biomarker_for a owl:ObjectProperty ;
    rdfs:label "biomarker for" ;
    rdfs:domain biolink:ChemicalEntityOrGeneOrGeneProduct ;
    rdfs:range biolink:DiseaseOrPhenotypicFeature ;
    rdfs:subPropertyOf biolink:correlated_with ;
    owl:inverseOf biolink:has_biomarker ;
    skos:broadMatch RO:0002607 ;
    skos:definition "holds between a measurable chemical entity and a disease or phenotypic feature, where the entity is used as an indicator of the presence or state of the disease or feature." ;
    skos:exactMatch <http://purl.obolibrary.org/obo/NCIT_R39> ;
    skos:narrowMatch <http://purl.obolibrary.org/obo/NCIT_R47>,
        <http://purl.obolibrary.org/obo/NCIT_genetic_biomarker_related_to>,
        <http://purl.obolibrary.org/obo/NCIT_is_molecular_abnormality_of_disease>,
        orphanet:465410 ;
    biolink:canonical_predicate "True" .

biolink:can_be_carried_out_by a owl:ObjectProperty ;
    rdfs:label "can be carried out by" ;
    rdfs:domain biolink:Occurrent ;
    rdfs:range biolink:Occurrent ;
    rdfs:subPropertyOf biolink:actively_involves ;
    owl:inverseOf biolink:capable_of .

biolink:capable_of a owl:ObjectProperty ;
    rdfs:label "capable of" ;
    rdfs:domain biolink:Occurrent ;
    rdfs:range biolink:Occurrent ;
    rdfs:subPropertyOf biolink:actively_involved_in ;
    owl:inverseOf biolink:can_be_carried_out_by ;
    skos:definition "holds between a physical entity and process or function, where the continuant alone has the ability to carry out the process or function." ;
    skos:exactMatch RO:0002215 ;
    skos:narrowMatch <http://purl.obolibrary.org/obo/NCIT_R52>,
        RO:0002500 ;
    biolink:canonical_predicate "True" .

biolink:catalyst_qualifier a owl:ObjectProperty ;
    rdfs:label "catalyst qualifier" ;
    rdfs:domain biolink:Association ;
    rdfs:range biolink:MacromolecularMachineMixin ;
    rdfs:subPropertyOf biolink:association_slot ;
    skos:definition "a qualifier that connects an association between two causally connected entities (for example, two chemical entities, or a chemical entity in that changes location) and the gene product, gene, or complex that enables or catalyzes the change." .

biolink:catalyzes a owl:ObjectProperty ;
    rdfs:label "catalyzes" ;
    rdfs:domain biolink:NucleicAcidEntity ;
    rdfs:range biolink:MolecularActivity ;
    rdfs:subPropertyOf biolink:participates_in ;
    owl:inverseOf biolink:has_catalyst ;
    biolink:canonical_predicate "True" .

biolink:caused_by a owl:ObjectProperty ;
    rdfs:label "caused by" ;
    rdfs:domain biolink:NamedThing ;
    rdfs:range biolink:NamedThing ;
    rdfs:subPropertyOf biolink:contribution_from ;
    owl:inverseOf biolink:causes ;
    skos:altLabel "disease caused by disruption of",
        "disease has basis in dysfunction of",
        "realized in response to",
        "realized in response to stimulus" ;
    skos:definition "holds between two entities where the occurrence, existence, or activity of one is caused by the occurrence or generation of the other" ;
    skos:exactMatch WIKIDATA_PROPERTY:P828 ;
    skos:narrowMatch RO:0001022,
        RO:0002608,
        RO:0004019,
        RO:0004020,
        RO:0004028,
        RO:0009501 .

biolink:causes a owl:ObjectProperty ;
    rdfs:label "causes" ;
    rdfs:domain biolink:NamedThing ;
    rdfs:range biolink:NamedThing ;
    rdfs:subPropertyOf biolink:contributes_to ;
    owl:inverseOf biolink:caused_by ;
    skos:broadMatch RO:0002410,
        RO:0002506 ;
    skos:definition "holds between two entities where the occurrence, existence, or activity of one causes the occurrence or generation of the other" ;
    skos:exactMatch RO:0003303,
        <http://purl.obolibrary.org/obo/SNOMED_cause_of>,
        SEMMEDDB:CAUSES,
        WIKIDATA_PROPERTY:P1542 ;
    skos:narrowMatch <http://identifiers.org/umls/has_physiologic_effect>,
        GOREL:0000040,
        <http://purl.obolibrary.org/obo/MONDO_disease_causes_feature>,
        <http://purl.obolibrary.org/obo/MONDO_disease_triggers>,
        <http://purl.obolibrary.org/obo/NCIT_allele_has_abnormality>,
        <http://purl.obolibrary.org/obo/NCIT_biological_process_has_result_biological_process>,
        <http://purl.obolibrary.org/obo/NCIT_chemical_or_drug_has_physiologic_effect>,
        <http://purl.obolibrary.org/obo/NCIT_chemical_or_drug_initiates_biological_process>,
        <http://purl.obolibrary.org/obo/NCIT_chromosome_mapped_to_disease>,
        <http://purl.obolibrary.org/obo/NCIT_disease_has_normal_tissue_origin>,
        <http://purl.obolibrary.org/obo/NCIT_process_initiates_biological_process>,
        RO:0002256,
        RO:0002315,
        RO:0002507,
        RO:0002509,
        RO:0004001,
        <http://purl.obolibrary.org/obo/SNOMED_causative_agent_of>,
        <http://purl.obolibrary.org/obo/SNOMED_has_realization>,
        NBO-PROPERTY:in_response_to,
        orphanet:317343,
        orphanet:317344,
        orphanet:317346,
        orphanet:410295,
        orphanet:410296 ;
    biolink:canonical_predicate "True" ;
    biolink:opposite_of "prevents" .

biolink:chapter a owl:ObjectProperty ;
    rdfs:label "chapter" ;
    rdfs:domain biolink:BookChapter ;
    rdfs:range linkml:String ;
    rdfs:subPropertyOf biolink:node_property ;
    skos:definition "chapter of a book" ;
    skos:exactMatch WIKIDATA:Q1980247 .

biolink:close_match a owl:ObjectProperty,
        owl:SymmetricProperty ;
    rdfs:label "close match" ;
    rdfs:domain biolink:NamedThing ;
    rdfs:range biolink:NamedThing ;
    rdfs:subPropertyOf biolink:related_to_at_concept_level ;
    skos:definition "a list of terms from different schemas or terminology systems that have a semantically similar but not strictly equivalent, broader, or narrower meaning. Such terms often describe the same general concept from different ontological perspectives (e.g. drug as a type of chemical entity versus drug as a type of role borne by a chemical entity)." ;
    skos:exactMatch skos:closeMatch,
        SEMMEDDB:same_as ;
    skos:narrowMatch <http://identifiers.org/meddra/classified_as>,
        <http://identifiers.org/umls/SY>,
        RXNORM:has_quantified_form,
        <http://purl.obolibrary.org/obo/CHEBI_is_enantiomer_of>,
        <http://purl.obolibrary.org/obo/CHEBI_is_tautomer_of>,
        oboformat:hasDbXref,
        oboformat:xref ;
    biolink:canonical_predicate "True" .

biolink:completed_by a owl:ObjectProperty ;
    rdfs:label "completed by" ;
    rdfs:domain biolink:NamedThing ;
    rdfs:range biolink:NamedThing ;
    rdfs:subPropertyOf biolink:related_to_at_instance_level ;
    owl:inverseOf biolink:has_completed .

biolink:composed_primarily_of a owl:ObjectProperty ;
    rdfs:label "composed primarily of" ;
    rdfs:domain biolink:NamedThing ;
    rdfs:range biolink:NamedThing ;
    rdfs:subPropertyOf biolink:related_to ;
    owl:inverseOf biolink:primarily_composed_of ;
    skos:definition "x composed_primarily_of_y if:more than half of the mass of x is made from parts of y." ;
    skos:exactMatch RO:0002473 ;
    biolink:canonical_predicate "True" .

biolink:condition_associated_with_gene a owl:ObjectProperty ;
    rdfs:label "condition associated with gene" ;
    rdfs:domain biolink:Gene ;
    rdfs:range biolink:DiseaseOrPhenotypicFeature ;
    rdfs:subPropertyOf biolink:genetic_association ;
    owl:inverseOf biolink:gene_associated_with_condition ;
    skos:altLabel "disease associated with gene" ;
    skos:definition "holds between a gene and a disease or phenotypic feature that may be influenced, contribute to, or be correlated with the gene or its alleles/products" ;
    skos:narrowMatch <http://purl.obolibrary.org/obo/NCIT_R176> .

biolink:consumed_by a owl:ObjectProperty ;
    rdfs:label "consumed by" ;
    rdfs:domain biolink:Occurrent ;
    rdfs:range biolink:BiologicalProcessOrActivity ;
    rdfs:subPropertyOf biolink:is_input_of ;
    owl:inverseOf biolink:consumes .

biolink:consumes a owl:ObjectProperty ;
    rdfs:label "consumes" ;
    rdfs:domain biolink:BiologicalProcessOrActivity ;
    rdfs:range biolink:Occurrent ;
    rdfs:subPropertyOf biolink:has_input ;
    owl:inverseOf biolink:consumed_by ;
    skos:narrowMatch RO:0004009 ;
    biolink:canonical_predicate "True" .

biolink:contains_process a owl:ObjectProperty ;
    rdfs:label "contains process" ;
    rdfs:domain biolink:NamedThing ;
    rdfs:range biolink:NamedThing ;
    rdfs:subPropertyOf biolink:related_to_at_instance_level ;
    owl:inverseOf biolink:occurs_in .

biolink:contraindicated_for a owl:ObjectProperty ;
    rdfs:label "contraindicated for" ;
    rdfs:domain biolink:Drug ;
    rdfs:range biolink:DiseaseOrPhenotypicFeature ;
    rdfs:subPropertyOf biolink:related_to_at_instance_level ;
    owl:inverseOf biolink:has_contraindication ;
    skos:definition "Holds between a drug and a disease or phenotype, such that a person with that disease should not be treated with the drug." ;
    skos:exactMatch <http://purl.obolibrary.org/obo/NCIT_C37933> ;
    biolink:canonical_predicate "True" ;
    biolink:opposite_of "treats" .

biolink:creation_date a owl:ObjectProperty ;
    rdfs:label "creation date" ;
    rdfs:domain biolink:NamedThing ;
    rdfs:range linkml:Date ;
    rdfs:subPropertyOf biolink:node_property ;
    skos:altLabel "publication date" ;
    skos:definition "date on which an entity was created. This can be applied to nodes or edges" ;
    skos:exactMatch dct:createdOn,
        WIKIDATA_PROPERTY:P577 .

biolink:decreased_amount_in a owl:ObjectProperty ;
    rdfs:label "decreased amount in" ;
    rdfs:domain biolink:NamedThing ;
    rdfs:range biolink:NamedThing ;
    rdfs:subPropertyOf biolink:related_to_at_instance_level ;
    owl:inverseOf biolink:has_decreased_amount .

biolink:decreased_likelihood_associated_with a owl:ObjectProperty ;
    rdfs:label "decreased likelihood associated with" ;
    rdfs:domain biolink:NamedThing ;
    rdfs:range biolink:NamedThing ;
    rdfs:subPropertyOf biolink:likelihood_associated_with ;
    owl:inverseOf biolink:associated_with_decreased_likelihood_of ;
    skos:definition "" .

biolink:decreases_amount_or_activity_of a owl:ObjectProperty ;
    rdfs:label "decreases amount or activity of" ;
    rdfs:domain biolink:NamedThing ;
    rdfs:range biolink:NamedThing ;
    rdfs:subPropertyOf biolink:related_to_at_instance_level ;
    owl:inverseOf biolink:amount_or_activity_decreased_by ;
    skos:definition "A grouping mixin to help with searching for all the predicates that decrease the amount or activity of the object." .

biolink:decreases_response_to a owl:ObjectProperty ;
    rdfs:label "decreases response to" ;
    rdfs:domain biolink:ChemicalEntityOrGeneOrGeneProduct ;
    rdfs:range biolink:ChemicalEntityOrGeneOrGeneProduct ;
    rdfs:subPropertyOf biolink:affects_response_to ;
    owl:inverseOf biolink:response_decreased_by ;
    skos:definition "holds between two chemical entities where the action or effect of one decreases the susceptibility of a biological entity or system (e.g. an organism, cell, cellular component, macromolecular machine mixin, biological or pathological process) to the other" ;
    skos:exactMatch CTD:decreases_response_to ;
    skos:narrowMatch CTD:decreases_response_to_substance ;
    biolink:canonical_predicate "True" ;
    biolink:opposite_of "increases response to" .

biolink:develops_from a owl:ObjectProperty ;
    rdfs:label "develops from" ;
    rdfs:domain biolink:NamedThing ;
    rdfs:range biolink:NamedThing ;
    rdfs:subPropertyOf biolink:related_to_at_instance_level ;
    owl:inverseOf biolink:develops_into ;
    skos:closeMatch <http://purl.obolibrary.org/obo/FMA_develops_into>,
        RO:0002203 ;
    skos:exactMatch <http://purl.obolibrary.org/obo/BTO_develops_from>,
        <http://purl.obolibrary.org/obo/DDANAT_develops_from>,
        <http://purl.obolibrary.org/obo/FMA_develops_from>,
        RO:0002202 ;
    skos:narrowMatch RO:0002207,
        RO:0002225,
        RO:0002226 ;
    biolink:canonical_predicate "True" .

biolink:develops_into a owl:ObjectProperty ;
    rdfs:label "develops into" ;
    rdfs:domain biolink:NamedThing ;
    rdfs:range biolink:NamedThing ;
    rdfs:subPropertyOf biolink:related_to_at_instance_level ;
    owl:inverseOf biolink:develops_from .

biolink:diagnoses a owl:ObjectProperty ;
    rdfs:label "diagnoses" ;
    rdfs:domain biolink:ChemicalOrDrugOrTreatment ;
    rdfs:range biolink:DiseaseOrPhenotypicFeature ;
    rdfs:subPropertyOf biolink:related_to_at_instance_level ;
    owl:inverseOf biolink:is_diagnosed_by ;
    skos:closeMatch <http://purl.obolibrary.org/obo/NCIT_C15220>,
        SIO:001331 ;
    skos:definition "a relationship that identifies the nature of (an illness or other problem) by examination of the symptoms." ;
    skos:exactMatch DrugCentral:5271,
        SEMMEDDB:DIAGNOSES ;
    biolink:canonical_predicate "True" .

biolink:directly_physically_interacts_with a owl:ObjectProperty,
        owl:SymmetricProperty ;
    rdfs:label "directly physically interacts with" ;
    rdfs:domain biolink:NamedThing ;
    rdfs:range biolink:NamedThing ;
    rdfs:subPropertyOf biolink:physically_interacts_with ;
    skos:broadMatch RO:0002578,
        SIO:000203 ;
    skos:definition "A causal mechanism mediated by a direct contact between the effector and target entities (this contact may  be weak or strong, transient or stable)." ;
    skos:exactMatch RO:0002436 ;
    skos:narrowMatch CTD:affects_binding,
        <http://identifiers.org/drugbank/chelator>,
        PHAROS:drug_targets,
        DGIdb:cofactor ;
    biolink:canonical_predicate "True" .

biolink:disease_has_basis_in a owl:ObjectProperty ;
    rdfs:label "disease has basis in" ;
    rdfs:domain biolink:NamedThing ;
    rdfs:range biolink:NamedThing ;
    rdfs:subPropertyOf biolink:related_to_at_instance_level ;
    owl:inverseOf biolink:occurs_in_disease ;
    skos:definition "A relation that holds between a disease and an entity where the state of the entity has contribution to the disease." ;
    skos:narrowMatch <http://purl.obolibrary.org/obo/MONDO_disease_has_basis_in_accumulation_of>,
        <http://purl.obolibrary.org/obo/MONDO_disease_has_basis_in_development_of> ;
    biolink:canonical_predicate "True" .

biolink:disease_has_location a owl:ObjectProperty ;
    rdfs:label "disease has location" ;
    rdfs:domain biolink:NamedThing ;
    rdfs:range biolink:NamedThing ;
    rdfs:subPropertyOf biolink:related_to ;
    owl:inverseOf biolink:location_of_disease ;
    skos:definition "A relationship between a disease and an anatomical entity where the disease has one or more features that are located in that entity." ;
    skos:exactMatch <http://purl.obolibrary.org/obo/MONDO_disease_has_location>,
        RO:0004026 .

biolink:disrupted_by a owl:ObjectProperty ;
    rdfs:label "disrupted by" ;
    rdfs:domain biolink:NamedThing ;
    rdfs:range biolink:NamedThing ;
    rdfs:subPropertyOf biolink:affected_by ;
    owl:inverseOf biolink:disrupts ;
    skos:definition "describes a relationship where the structure, function, or occurrence of one entity is degraded or interfered with by another." .

biolink:disrupts a owl:ObjectProperty ;
    rdfs:label "disrupts" ;
    rdfs:domain biolink:NamedThing ;
    rdfs:range biolink:NamedThing ;
    rdfs:subPropertyOf biolink:affects ;
    owl:inverseOf biolink:disrupted_by ;
    skos:altLabel "disease causes disruption of" ;
    skos:definition "describes a relationship where one entity degrades or interferes with the structure, function, or occurrence of another." ;
    skos:exactMatch SEMMEDDB:DISRUPTS,
        CHEMBL.MECHANISM:disrupting_agent ;
    skos:narrowMatch RO:0004024,
        RO:0004025 ;
    biolink:canonical_predicate "True" ;
    biolink:opposite_of "enables" .

biolink:distribution_download_url a owl:ObjectProperty ;
    rdfs:label "distribution download url" ;
    rdfs:domain biolink:DatasetDistribution ;
    rdfs:range linkml:String ;
    rdfs:subPropertyOf biolink:node_property ;
    skos:exactMatch dcat:downloadURL .

biolink:drug_regulatory_status_world_wide a owl:ObjectProperty ;
    rdfs:label "drug regulatory status world wide" ;
    rdfs:range linkml:String ;
    skos:altLabel "max phase" ;
    skos:definition "An agglomeration of drug regulatory status worldwide. Not specific to FDA." ;
    skos:exactMatch <http://purl.obolibrary.org/obo/NCIT_C172573> ;
    skos:narrowMatch REPODB:clinically_tested_approved_unknown_phase,
        REPODB:clinically_tested_suspended_phase_0,
        REPODB:clinically_tested_suspended_phase_1,
        REPODB:clinically_tested_suspended_phase_1_or_phase_2,
        REPODB:clinically_tested_suspended_phase_2,
        REPODB:clinically_tested_suspended_phase_2_or_phase_3,
        REPODB:clinically_tested_suspended_phase_3,
        REPODB:clinically_tested_terminated_phase_0,
        REPODB:clinically_tested_terminated_phase_1,
        REPODB:clinically_tested_terminated_phase_1_or_phase_2,
        REPODB:clinically_tested_terminated_phase_2,
        REPODB:clinically_tested_terminated_phase_2_or_phase_3,
        REPODB:clinically_tested_terminated_phase_3,
        REPODB:clinically_tested_withdrawn_phase_0,
        REPODB:clinically_tested_withdrawn_phase_1,
        REPODB:clinically_tested_withdrawn_phase_1_or_phase_2,
        REPODB:clinically_tested_withdrawn_phase_2,
        REPODB:clinically_tested_withdrawn_phase_2_or_phase_3,
        REPODB:clinically_tested_withdrawn_phase_3,
        <http://purl.obolibrary.org/obo/NCIT_R172>,
        <http://purl.obolibrary.org/obo/NCIT_regimen_has_accepted_use_for_disease> .

biolink:editor a owl:ObjectProperty ;
    rdfs:label "editor" ;
    rdfs:domain biolink:Agent ;
    rdfs:range biolink:Publication ;
    rdfs:subPropertyOf biolink:contributor ;
    owl:inverseOf biolink:has_editor ;
    skos:definition "editor of a compiled work such as a book or a periodical (newspaper or an academic journal). Note that in the case of publications which have a containing \"published in\" node property, the editor association may not be attached directly to the embedded child publication, but only made in between the parent's publication node and the editorial agent of the encompassing publication (e.g. only from the Book referenced by the 'published_in' property of a book chapter Publication node)." ;
    skos:exactMatch WIKIDATA_PROPERTY:P98 .

biolink:enables a owl:ObjectProperty ;
    rdfs:label "enables" ;
    rdfs:domain biolink:PhysicalEntity ;
    rdfs:range biolink:BiologicalProcessOrActivity ;
    rdfs:subPropertyOf biolink:participates_in ;
    owl:inverseOf biolink:enabled_by ;
    skos:definition "holds between a physical entity and a process, where the physical entity executes the process" ;
    skos:exactMatch RO:0002327 ;
    biolink:canonical_predicate "True" ;
    biolink:opposite_of "prevents" .

biolink:end_interbase_coordinate a owl:ObjectProperty ;
    rdfs:label "end interbase coordinate" ;
    rdfs:domain biolink:GenomicSequenceLocalization ;
    rdfs:range linkml:Integer ;
    rdfs:subPropertyOf biolink:interbase_coordinate ;
    skos:closeMatch <http://biohackathon.org/resource/faldo#end> ;
    skos:definition "The position at which the subject nucleic acid entity ends on the chromosome or other entity to which it is located on." ;
    biolink:opposite_of "start interbase coordinate" .

biolink:exacerbates a owl:ObjectProperty ;
    rdfs:label "exacerbates" ;
    rdfs:domain biolink:BiologicalEntity ;
    rdfs:range biolink:DiseaseOrPhenotypicFeature ;
    rdfs:subPropertyOf biolink:affects ;
    owl:inverseOf biolink:is_exacerbated_by ;
    skos:broadMatch SEMMEDDB:COMPLICATES ;
    skos:definition "A relationship between an entity (e.g. a chemical, environmental exposure, or some form of genetic variation) and a condition (a phenotype or disease), where the presence of the entity worsens some or all aspects of the condition." ;
    skos:exactMatch RO:0003309 ;
    biolink:canonical_predicate "True" .

biolink:expressed_in a owl:ObjectProperty ;
    rdfs:label "expressed in" ;
    rdfs:domain biolink:GeneOrGeneProduct ;
    rdfs:range biolink:AnatomicalEntity ;
    rdfs:subPropertyOf biolink:located_in ;
    owl:inverseOf biolink:expresses ;
    skos:definition "holds between a gene or gene product and an anatomical entity in which it is expressed" ;
    skos:exactMatch RO:0002206 ;
    skos:narrowMatch <http://purl.obolibrary.org/obo/NCIT_R46>,
        <http://purl.obolibrary.org/obo/NCIT_R49> ;
    biolink:canonical_predicate "True" .

biolink:expresses a owl:ObjectProperty ;
    rdfs:label "expresses" ;
    rdfs:domain biolink:AnatomicalEntity ;
    rdfs:range biolink:GeneOrGeneProduct ;
    rdfs:subPropertyOf biolink:location_of ;
    owl:inverseOf biolink:expressed_in ;
    skos:altLabel "anatomy expresses gene" ;
    skos:definition "holds between an anatomical entity and gene or gene product that is expressed there" ;
    skos:exactMatch RO:0002292 .

biolink:format a owl:ObjectProperty ;
    rdfs:label "format" ;
    rdfs:domain biolink:InformationContentEntity ;
    rdfs:range linkml:String ;
    rdfs:subPropertyOf biolink:node_property ;
    skos:exactMatch dct:format,
        WIKIDATA_PROPERTY:P2701 .

biolink:gene_associated_with_condition a owl:ObjectProperty ;
    rdfs:label "gene associated with condition" ;
    rdfs:domain biolink:DiseaseOrPhenotypicFeature ;
    rdfs:range biolink:Gene ;
    rdfs:subPropertyOf biolink:genetic_association ;
    owl:inverseOf biolink:condition_associated_with_gene ;
    skos:broadMatch <http://purl.obolibrary.org/obo/GENO_0000840>,
        <http://purl.obolibrary.org/obo/GENO_0000841> ;
    skos:definition "holds between a gene and a disease or phenotypic feature that the gene or its alleles/products may influence, contribute to, or correlate with" ;
    skos:narrowMatch <http://purl.obolibrary.org/obo/NCIT_R175>,
        <http://purl.obolibrary.org/obo/NCIT_R38>,
        <http://purl.obolibrary.org/obo/NCIT_R48> ;
    biolink:canonical_predicate "True" .

biolink:gene_product_of a owl:ObjectProperty ;
    rdfs:label "gene product of" ;
    rdfs:domain biolink:GeneProductMixin ;
    rdfs:range biolink:Gene ;
    rdfs:subPropertyOf biolink:related_to_at_instance_level ;
    owl:inverseOf biolink:has_gene_product ;
    skos:definition "definition x has gene product of y if and only if y is a gene (SO:0000704) that participates in some gene expression process (GO:0010467) where the output of thatf process is either y or something that is ribosomally translated from x" ;
    skos:exactMatch RO:0002204 ;
    biolink:canonical_predicate "True" .

biolink:genome_build a owl:ObjectProperty ;
    rdfs:label "genome build" ;
    rdfs:domain biolink:GenomicSequenceLocalization ;
    rdfs:range biolink:StrandEnum ;
    rdfs:subPropertyOf biolink:sequence_localization_attribute ;
    skos:definition "The version of the genome on which a feature is located. For example, GRCh38 for Homo sapiens." ;
    skos:exactMatch gff3:strand .

biolink:has_active_component a owl:ObjectProperty ;
    rdfs:label "has active component" ;
    rdfs:domain biolink:CellularComponent ;
    rdfs:range biolink:GeneOrGeneProduct ;
    rdfs:subPropertyOf biolink:related_to_at_instance_level ;
    owl:inverseOf biolink:active_in .

biolink:has_active_ingredient a owl:ObjectProperty ;
    rdfs:label "has active ingredient" ;
    rdfs:domain biolink:Drug ;
    rdfs:range biolink:MolecularEntity ;
    rdfs:subPropertyOf biolink:has_part ;
    owl:inverseOf biolink:is_active_ingredient_of ;
    skos:definition "holds between a drug and a molecular entity in which the latter is a part of the former, and is a biologically active component" ;
    skos:exactMatch RO:0002248 ;
    biolink:canonical_predicate "True" ;
    biolink:opposite_of "is excipient of" .

biolink:has_adverse_event a owl:ObjectProperty ;
    rdfs:label "has adverse event" ;
    rdfs:domain biolink:ChemicalOrDrugOrTreatment ;
    rdfs:range biolink:DiseaseOrPhenotypicFeature ;
    rdfs:subPropertyOf biolink:affects ;
    owl:inverseOf biolink:adverse_event_of ;
    skos:altLabel "adverse effect" ;
    skos:definition "An untoward medical occurrence in a patient or clinical investigation subject that happens during treatment  with a therapeutic agent. Adverse events may be caused by something  other than the drug or therapy being given and may include abnormal laboratory finding, symptoms, or  diseases temporally associated with the treatment, whether or not considered related to the treatment.  Adverse events are unintended effects that occur when a medication is administered correctly." ;
    biolink:canonical_predicate "True" .

biolink:has_author a owl:ObjectProperty ;
    rdfs:label "has author" ;
    rdfs:domain biolink:Publication ;
    rdfs:range biolink:Agent ;
    rdfs:subPropertyOf biolink:has_contributor ;
    owl:inverseOf biolink:author .

biolink:has_biomarker a owl:ObjectProperty ;
    rdfs:label "has biomarker" ;
    rdfs:domain biolink:DiseaseOrPhenotypicFeature ;
    rdfs:range biolink:ChemicalEntityOrGeneOrGeneProduct ;
    rdfs:subPropertyOf biolink:correlated_with ;
    owl:inverseOf biolink:biomarker_for ;
    skos:definition "holds between a disease or phenotypic feature and a measurable chemical entity that is used as an indicator of the presence or state of the disease or feature. # metabolite" ;
    skos:narrowMatch <http://purl.obolibrary.org/obo/NCIT_disease_has_molecular_abnormality>,
        <http://purl.obolibrary.org/obo/NCIT_disease_is_marked_by_gene> .

biolink:has_catalyst a owl:ObjectProperty ;
    rdfs:label "has catalyst" ;
    rdfs:domain biolink:MolecularActivity ;
    rdfs:range biolink:NucleicAcidEntity ;
    rdfs:subPropertyOf biolink:has_participant ;
    owl:inverseOf biolink:catalyzes .

biolink:has_chemical_role a owl:ObjectProperty ;
    rdfs:label "has chemical role" ;
    rdfs:domain biolink:NamedThing ;
    rdfs:range biolink:ChemicalRole ;
    rdfs:subPropertyOf biolink:related_to_at_concept_level ;
    skos:definition "A role is particular behaviour which a chemical entity may exhibit." .

biolink:has_completed a owl:ObjectProperty ;
    rdfs:label "has completed" ;
    rdfs:domain biolink:NamedThing ;
    rdfs:range biolink:NamedThing ;
    rdfs:subPropertyOf biolink:related_to_at_instance_level ;
    owl:inverseOf biolink:completed_by ;
    skos:definition "holds between an entity and a process that the entity is capable of and has completed" ;
    skos:exactMatch <http://purl.obolibrary.org/obo/CL_has_completed> ;
    biolink:canonical_predicate "True" ;
    biolink:opposite_of "has not completed" .

biolink:has_contraindication a owl:ObjectProperty ;
    rdfs:label "has contraindication" ;
    rdfs:domain biolink:DiseaseOrPhenotypicFeature ;
    rdfs:range biolink:Drug ;
    rdfs:subPropertyOf biolink:related_to_at_instance_level ;
    owl:inverseOf biolink:contraindicated_for .

biolink:has_decreased_amount a owl:ObjectProperty ;
    rdfs:label "has decreased amount" ;
    rdfs:domain biolink:NamedThing ;
    rdfs:range biolink:NamedThing ;
    rdfs:subPropertyOf biolink:related_to_at_instance_level ;
    owl:inverseOf biolink:decreased_amount_in ;
    skos:narrowMatch <http://purl.obolibrary.org/obo/CL_has_low_plasma_membrane_amount> ;
    biolink:canonical_predicate "True" ;
    biolink:opposite_of "has increased amount" .

biolink:has_device a owl:ObjectProperty ;
    rdfs:label "has device" ;
    rdfs:domain biolink:NamedThing ;
    rdfs:range biolink:Device ;
    rdfs:subPropertyOf biolink:node_property ;
    skos:definition "connects an entity to one or more (medical) devices" .

biolink:has_drug a owl:ObjectProperty ;
    rdfs:label "has drug" ;
    rdfs:domain biolink:NamedThing ;
    rdfs:range biolink:Drug ;
    rdfs:subPropertyOf biolink:node_property ;
    skos:definition "connects an entity to one or more drugs" .

biolink:has_editor a owl:ObjectProperty ;
    rdfs:label "has editor" ;
    rdfs:domain biolink:Publication ;
    rdfs:range biolink:Agent ;
    rdfs:subPropertyOf biolink:has_contributor ;
    owl:inverseOf biolink:editor .

biolink:has_excipient a owl:ObjectProperty ;
    rdfs:label "has excipient" ;
    rdfs:domain biolink:Drug ;
    rdfs:range biolink:MolecularEntity ;
    rdfs:subPropertyOf biolink:has_part ;
    owl:inverseOf biolink:is_excipient_of ;
    skos:definition "holds between a drug and a molecular entities in which the latter is a part of the former, and is a biologically inactive component" ;
    skos:exactMatch WIKIDATA:Q902638 ;
    biolink:canonical_predicate "True" .

biolink:has_frameshift_variant a owl:ObjectProperty ;
    rdfs:label "has frameshift variant" ;
    rdfs:domain biolink:GenomicEntity ;
    rdfs:range biolink:SequenceVariant ;
    rdfs:subPropertyOf biolink:has_sequence_variant ;
    owl:inverseOf biolink:is_frameshift_variant_of ;
    skos:altLabel "splice acceptor variant",
        "splice donor variant",
        "splice region variant" .

biolink:has_gene a owl:ObjectProperty ;
    rdfs:label "has gene" ;
    rdfs:domain biolink:NamedThing ;
    rdfs:range biolink:Gene ;
    rdfs:subPropertyOf biolink:has_gene_or_gene_product ;
    skos:definition "connects an entity associated with one or more genes" .

biolink:has_gene_product a owl:ObjectProperty ;
    rdfs:label "has gene product" ;
    rdfs:domain biolink:Gene ;
    rdfs:range biolink:GeneProductMixin ;
    rdfs:subPropertyOf biolink:related_to_at_instance_level ;
    owl:inverseOf biolink:gene_product_of ;
    skos:closeMatch <http://purl.obolibrary.org/obo/PR_has_gene_template> ;
    skos:definition "holds between a gene and a transcribed and/or translated product generated from it" ;
    skos:exactMatch <http://purl.obolibrary.org/obo/NCIT_gene_encodes_gene_product>,
        RO:0002205,
        WIKIDATA_PROPERTY:P688 ;
    skos:narrowMatch <http://purl.obolibrary.org/obo/NCIT_R178> .

biolink:has_increased_amount a owl:ObjectProperty ;
    rdfs:label "has increased amount" ;
    rdfs:domain biolink:NamedThing ;
    rdfs:range biolink:NamedThing ;
    rdfs:subPropertyOf biolink:related_to_at_instance_level ;
    owl:inverseOf biolink:increased_amount_of ;
    skos:narrowMatch <http://purl.obolibrary.org/obo/CL_has_high_plasma_membrane_amount> ;
    biolink:canonical_predicate "True" ;
    biolink:opposite_of "has decreased amount" .

biolink:has_member a owl:ObjectProperty ;
    rdfs:label "has member" ;
    rdfs:domain biolink:NamedThing ;
    rdfs:range biolink:NamedThing ;
    rdfs:subPropertyOf biolink:related_to_at_concept_level ;
    owl:inverseOf biolink:member_of ;
    skos:definition "Defines a mereological relation between a collection and an item." ;
    skos:exactMatch RO:0002351,
        skos:member .

biolink:has_metabolite a owl:ObjectProperty ;
    rdfs:label "has metabolite" ;
    rdfs:domain biolink:MolecularEntity ;
    rdfs:range biolink:MolecularEntity ;
    rdfs:subPropertyOf biolink:derives_into ;
    owl:inverseOf biolink:is_metabolite_of ;
    skos:definition "holds between two molecular entities in which the second one is derived from the first one as a product of metabolism" ;
    skos:exactMatch <http://purl.obolibrary.org/obo/CHEBI_25212> ;
    skos:note "The CHEBI ID represents a role rather than a predicate" ;
    biolink:canonical_predicate "True" .

biolink:has_missense_variant a owl:ObjectProperty ;
    rdfs:label "has missense variant" ;
    rdfs:domain biolink:GenomicEntity ;
    rdfs:range biolink:SequenceVariant ;
    rdfs:subPropertyOf biolink:has_sequence_variant ;
    owl:inverseOf biolink:is_missense_variant_of .

biolink:has_mode_of_inheritance a owl:ObjectProperty ;
    rdfs:label "has mode of inheritance" ;
    rdfs:domain biolink:DiseaseOrPhenotypicFeature ;
    rdfs:range biolink:GeneticInheritance ;
    rdfs:subPropertyOf biolink:has_manifestation ;
    owl:inverseOf biolink:mode_of_inheritance_of ;
    skos:definition "Relates a disease or phenotypic feature to its observed genetic segregation and assumed associated underlying DNA manifestation (i.e. autosomal, sex or mitochondrial chromosome)." ;
    biolink:canonical_predicate "True" .

biolink:has_molecular_consequence a owl:ObjectProperty ;
    rdfs:label "has molecular consequence" ;
    rdfs:domain biolink:NamedThing ;
    rdfs:range biolink:OntologyClass ;
    rdfs:subPropertyOf biolink:related_to_at_instance_level ;
    owl:inverseOf biolink:is_molecular_consequence_of ;
    skos:altLabel "allele has activity" ;
    skos:definition "connects a sequence variant to a class describing the molecular consequence. E.g.  SO:0001583" ;
    skos:narrowMatch <http://purl.obolibrary.org/obo/NCIT_allele_has_activity> ;
    biolink:canonical_predicate "True" .

biolink:has_nearby_variant a owl:ObjectProperty ;
    rdfs:label "has nearby variant" ;
    rdfs:domain biolink:GenomicEntity ;
    rdfs:range biolink:SequenceVariant ;
    rdfs:subPropertyOf biolink:has_sequence_variant ;
    owl:inverseOf biolink:is_nearby_variant_of ;
    skos:altLabel "3 prime UTR variant",
        "5 prime UTR premature start codon gain variant",
        "5 prime UTR variant",
        "intron variant",
        "non coding transcript exon variant" .

biolink:has_negative_upstream_actor a owl:ObjectProperty ;
    rdfs:label "has negative upstream actor" ;
    rdfs:domain biolink:BiologicalProcess ;
    rdfs:range biolink:GeneOrGeneProduct ;
    rdfs:subPropertyOf biolink:has_upstream_actor ;
    owl:inverseOf biolink:acts_upstream_of_negative_effect .

biolink:has_negative_upstream_or_within_actor a owl:ObjectProperty ;
    rdfs:label "has negative upstream or within actor" ;
    rdfs:domain biolink:BiologicalProcess ;
    rdfs:range biolink:GeneOrGeneProduct ;
    rdfs:subPropertyOf biolink:has_upstream_or_within_actor ;
    owl:inverseOf biolink:acts_upstream_of_or_within_negative_effect .

biolink:has_non_coding_variant a owl:ObjectProperty ;
    rdfs:label "has non coding variant" ;
    rdfs:domain biolink:GenomicEntity ;
    rdfs:range biolink:SequenceVariant ;
    rdfs:subPropertyOf biolink:has_sequence_variant ;
    owl:inverseOf biolink:is_non_coding_variant_of .

biolink:has_nonsense_variant a owl:ObjectProperty ;
    rdfs:label "has nonsense variant" ;
    rdfs:domain biolink:GenomicEntity ;
    rdfs:range biolink:SequenceVariant ;
    rdfs:subPropertyOf biolink:has_sequence_variant ;
    owl:inverseOf biolink:is_nonsense_variant_of .

biolink:has_not_completed a owl:ObjectProperty ;
    rdfs:label "has not completed" ;
    rdfs:domain biolink:NamedThing ;
    rdfs:range biolink:NamedThing ;
    rdfs:subPropertyOf biolink:related_to_at_instance_level ;
    owl:inverseOf biolink:not_completed_by ;
    skos:definition "holds between an entity and a process that the entity is capable of, but has not completed" ;
    skos:exactMatch <http://purl.obolibrary.org/obo/CL_has_not_completed> ;
    biolink:canonical_predicate "True" ;
    biolink:opposite_of "has completed" .

biolink:has_numeric_value a owl:ObjectProperty ;
    rdfs:label "has numeric value" ;
    rdfs:domain biolink:QuantityValue ;
    rdfs:range linkml:Double ;
    skos:definition "connects a quantity value to a number" ;
    skos:exactMatch qud:quantityValue .

biolink:has_nutrient a owl:ObjectProperty ;
    rdfs:label "has nutrient" ;
    rdfs:domain biolink:ChemicalEntity ;
    rdfs:range biolink:ChemicalEntity ;
    rdfs:subPropertyOf biolink:has_food_component ;
    owl:inverseOf biolink:nutrient_of ;
    skos:definition "one or more nutrients which are growth factors for a living organism" ;
    skos:exactMatch WIKIDATA:Q181394 ;
    biolink:canonical_predicate "True" .

biolink:has_phenotype a owl:ObjectProperty ;
    rdfs:label "has phenotype" ;
    rdfs:domain biolink:BiologicalEntity ;
    rdfs:range biolink:PhenotypicFeature ;
    rdfs:subPropertyOf biolink:related_to_at_instance_level ;
    owl:inverseOf biolink:phenotype_of ;
    skos:altLabel "disease presents symptom" ;
    skos:broadMatch <http://purl.obolibrary.org/obo/NCIT_R108>,
        <http://purl.obolibrary.org/obo/NCIT_R115> ;
    skos:definition "holds between a biological entity and a phenotype, where a phenotype is construed broadly as any kind of quality of an organism part, a collection of these qualities, or a change in quality or qualities (e.g. abnormally increased temperature). In SNOMEDCT, disorders with keyword 'characterized by' should translate into this predicate." ;
    skos:editorialNote "check the range" ;
    skos:exactMatch RO:0002200 ;
    skos:narrowMatch <http://purl.obolibrary.org/obo/NCIT_R89>,
        RO:0004022,
        DOID-PROPERTY:has_symptom ;
    biolink:canonical_predicate "True" .

biolink:has_plasma_membrane_part a owl:ObjectProperty ;
    rdfs:label "has plasma membrane part" ;
    rdfs:domain biolink:NamedThing ;
    rdfs:range biolink:NamedThing ;
    rdfs:subPropertyOf biolink:has_part ;
    owl:inverseOf biolink:plasma_membrane_part_of ;
    skos:definition "Holds between a cell c and a protein complex or protein p if and only if that cell has as part a plasma_membrane[GO:0005886], and that plasma membrane has p as part." ;
    skos:exactMatch RO:0002104 ;
    biolink:canonical_predicate "True" .

biolink:has_positive_upstream_actor a owl:ObjectProperty ;
    rdfs:label "has positive upstream actor" ;
    rdfs:domain biolink:BiologicalProcess ;
    rdfs:range biolink:GeneOrGeneProduct ;
    rdfs:subPropertyOf biolink:has_upstream_actor ;
    owl:inverseOf biolink:acts_upstream_of_positive_effect .

biolink:has_positive_upstream_or_within_actor a owl:ObjectProperty ;
    rdfs:label "has positive upstream or within actor" ;
    rdfs:domain biolink:BiologicalProcess ;
    rdfs:range biolink:GeneOrGeneProduct ;
    rdfs:subPropertyOf biolink:has_upstream_or_within_actor ;
    owl:inverseOf biolink:acts_upstream_of_or_within_positive_effect .

biolink:has_predisposing_factor a owl:ObjectProperty ;
    rdfs:label "has predisposing factor" ;
    rdfs:domain biolink:NamedThing ;
    rdfs:range biolink:NamedThing ;
    rdfs:subPropertyOf biolink:risk_affected_by ;
    owl:inverseOf biolink:predisposes .

biolink:has_procedure a owl:ObjectProperty ;
    rdfs:label "has procedure" ;
    rdfs:domain biolink:NamedThing ;
    rdfs:range biolink:Procedure ;
    rdfs:subPropertyOf biolink:node_property ;
    skos:definition "connects an entity to one or more (medical) procedures" .

biolink:has_provider a owl:ObjectProperty ;
    rdfs:label "has provider" ;
    rdfs:domain biolink:InformationContentEntity ;
    rdfs:range biolink:Agent ;
    rdfs:subPropertyOf biolink:has_contributor ;
    owl:inverseOf biolink:provider .

biolink:has_publisher a owl:ObjectProperty ;
    rdfs:label "has publisher" ;
    rdfs:domain biolink:Publication ;
    rdfs:range biolink:Agent ;
    rdfs:subPropertyOf biolink:has_contributor ;
    owl:inverseOf biolink:publisher .

biolink:has_qualitative_value a owl:ObjectProperty ;
    rdfs:label "has qualitative value" ;
    rdfs:domain biolink:Attribute ;
    rdfs:range biolink:NamedThing ;
    skos:definition "connects an attribute to a value" .

biolink:has_quantitative_value a owl:ObjectProperty ;
    rdfs:label "has quantitative value" ;
    rdfs:domain biolink:Attribute ;
    rdfs:range biolink:QuantityValue ;
    skos:definition "connects an attribute to a value" ;
    skos:exactMatch qud:quantityValue ;
    skos:narrowMatch <http://purl.obolibrary.org/obo/SNOMED_has_concentration_strength_numerator_value>,
        <http://purl.obolibrary.org/obo/SNOMED_has_presentation_strength_denominator_value>,
        <http://purl.obolibrary.org/obo/SNOMED_has_presentation_strength_numerator_value> .

biolink:has_sequence_location a owl:ObjectProperty ;
    rdfs:label "has sequence location" ;
    rdfs:domain biolink:NucleicAcidEntity ;
    rdfs:range biolink:NucleicAcidEntity ;
    rdfs:subPropertyOf biolink:related_to_at_instance_level ;
    owl:inverseOf biolink:sequence_location_of ;
    skos:definition "holds between two nucleic acid entities when the subject can be localized in sequence coordinates on the object. For example, between an exon and a chromosome/contig." ;
    skos:exactMatch <http://biohackathon.org/resource/faldo#location> ;
    biolink:canonical_predicate "True" .

biolink:has_side_effect a owl:ObjectProperty ;
    rdfs:label "has side effect" ;
    rdfs:domain biolink:ChemicalOrDrugOrTreatment ;
    rdfs:range biolink:DiseaseOrPhenotypicFeature ;
    rdfs:subPropertyOf biolink:affects ;
    owl:inverseOf biolink:is_side_effect_of ;
    skos:altLabel "adverse drug reaction" ;
    skos:definition "An unintended, but predictable, secondary effect shown to be correlated with a therapeutic agent, drug or treatment. Side effects happen at normal, recommended doses or treatments, and are unrelated to the intended purpose of  the medication." ;
    skos:editorialNote "Side effects are listed on drug labels. There can be positive side effects, while adverse events are always negative. Aeolus, Sider are both resources that provide side effects." ;
    skos:exactMatch <http://purl.obolibrary.org/obo/NCIT_C2861> ;
    biolink:canonical_predicate "True" .

biolink:has_splice_site_variant a owl:ObjectProperty ;
    rdfs:label "has splice site variant" ;
    rdfs:domain biolink:GenomicEntity ;
    rdfs:range biolink:SequenceVariant ;
    rdfs:subPropertyOf biolink:has_sequence_variant ;
    owl:inverseOf biolink:is_splice_site_variant_of ;
    skos:altLabel "downstream gene variant",
        "upstream gene variant" .

biolink:has_substrate a owl:ObjectProperty ;
    rdfs:label "has substrate" ;
    rdfs:domain biolink:MolecularActivity ;
    rdfs:range biolink:ChemicalEntityOrGeneOrGeneProduct ;
    rdfs:subPropertyOf biolink:has_participant ;
    owl:inverseOf biolink:is_substrate_of ;
    biolink:canonical_predicate "True" .

biolink:has_synonymous_variant a owl:ObjectProperty ;
    rdfs:label "has synonymous variant" ;
    rdfs:domain biolink:GenomicEntity ;
    rdfs:range biolink:SequenceVariant ;
    rdfs:subPropertyOf biolink:has_sequence_variant ;
    owl:inverseOf biolink:is_synonymous_variant_of ;
    skos:altLabel "stop gained" .

biolink:has_target a owl:ObjectProperty ;
    rdfs:label "has target" ;
    rdfs:domain biolink:Disease ;
    rdfs:range biolink:Gene ;
    rdfs:subPropertyOf biolink:related_to_at_instance_level ;
    owl:inverseOf biolink:target_for .

biolink:has_taxonomic_rank a owl:ObjectProperty ;
    rdfs:label "has taxonomic rank" ;
    rdfs:domain biolink:NamedThing ;
    rdfs:range biolink:TaxonomicRank ;
    rdfs:subPropertyOf biolink:node_property ;
    skos:exactMatch WIKIDATA:P105 .

biolink:has_unit a owl:ObjectProperty ;
    rdfs:label "has unit" ;
    rdfs:domain biolink:QuantityValue ;
    rdfs:range biolink:Unit ;
    skos:closeMatch UO-PROPERTY:is_unit_of,
        EFO:0001697 ;
    skos:definition "connects a quantity value to a unit" ;
    skos:exactMatch IAO:0000039,
        qud:unit ;
    skos:narrowMatch <http://purl.obolibrary.org/obo/SNOMED_has_concentration_strength_denominator_unit>,
        <http://purl.obolibrary.org/obo/SNOMED_has_concentration_strength_numerator_unit>,
        <http://purl.obolibrary.org/obo/SNOMED_has_presentation_strength_denominator_unit>,
        <http://purl.obolibrary.org/obo/SNOMED_has_presentation_strength_numerator_unit>,
        <http://purl.obolibrary.org/obo/SNOMED_has_unit_of_presentation> .

biolink:has_variant_part a owl:ObjectProperty ;
    rdfs:label "has variant part" ;
    rdfs:domain biolink:NamedThing ;
    rdfs:range biolink:NamedThing ;
    rdfs:subPropertyOf biolink:has_part ;
    owl:inverseOf biolink:variant_part_of ;
    skos:definition "holds between a nucleic acid entity and a nucleic acid entity that is a sub-component of it" ;
    skos:exactMatch <http://purl.obolibrary.org/obo/GENO_0000382> ;
    biolink:canonical_predicate "True" .

biolink:has_zygosity a owl:ObjectProperty ;
    rdfs:label "has zygosity" ;
    rdfs:domain biolink:NucleicAcidEntity ;
    rdfs:range biolink:Zygosity ;
    rdfs:subPropertyOf biolink:node_property .

biolink:highest_FDA_approval_status a owl:ObjectProperty ;
    rdfs:label "highest FDA approval status" ;
    rdfs:range linkml:String ;
    skos:definition "Should be the highest level of FDA approval this chemical entity or device has, regardless of which disease, condition or phenotype it is currently being reviewed to treat.  For specific levels of FDA approval for a specific condition, disease, phenotype, etc., see the association slot, 'FDA approval status.'" .

biolink:increased_amount_of a owl:ObjectProperty ;
    rdfs:label "increased amount of" ;
    rdfs:domain biolink:NamedThing ;
    rdfs:range biolink:NamedThing ;
    rdfs:subPropertyOf biolink:related_to_at_instance_level ;
    owl:inverseOf biolink:has_increased_amount .

biolink:increased_likelihood_associated_with a owl:ObjectProperty ;
    rdfs:label "increased likelihood associated with" ;
    rdfs:domain biolink:NamedThing ;
    rdfs:range biolink:NamedThing ;
    rdfs:subPropertyOf biolink:likelihood_associated_with ;
    owl:inverseOf biolink:associated_with_increased_likelihood_of ;
    skos:definition "" .

biolink:increases_amount_or_activity_of a owl:ObjectProperty ;
    rdfs:label "increases amount or activity of" ;
    rdfs:domain biolink:NamedThing ;
    rdfs:range biolink:NamedThing ;
    rdfs:subPropertyOf biolink:related_to_at_instance_level ;
    owl:inverseOf biolink:amount_or_activity_increased_by ;
    skos:definition "A grouping mixin to help with searching for all the predicates that increase the amount or activity of the object." .

biolink:increases_response_to a owl:ObjectProperty ;
    rdfs:label "increases response to" ;
    rdfs:domain biolink:ChemicalEntityOrGeneOrGeneProduct ;
    rdfs:range biolink:ChemicalEntityOrGeneOrGeneProduct ;
    rdfs:subPropertyOf biolink:affects_response_to ;
    owl:inverseOf biolink:response_increased_by ;
    skos:definition "holds between two chemical entities where the action or effect of one increases the susceptibility of a biological entity or system (e.g. an organism, cell, cellular component, macromolecular machine mixin, biological or pathological process) to the other" ;
    skos:exactMatch CTD:increases_response_to ;
    biolink:canonical_predicate "True" ;
    biolink:opposite_of "decreases response to" .

biolink:interacting_molecules_category a owl:ObjectProperty ;
    rdfs:label "interacting molecules category" ;
    rdfs:domain biolink:Association ;
    rdfs:range biolink:OntologyClass ;
    rdfs:subPropertyOf biolink:association_slot ;
    skos:exactMatch MI:1046 ;
    linkml:examples "Example(value='MI:1048', description='smallmolecule-protein')" .

biolink:iri a owl:ObjectProperty ;
    rdfs:label "iri" ;
    rdfs:range biolink:IriType ;
    skos:definition "An IRI for an entity. This is determined by the id using expansion rules." ;
    skos:exactMatch WIKIDATA_PROPERTY:P854 .

biolink:is_active_ingredient_of a owl:ObjectProperty ;
    rdfs:label "is active ingredient of" ;
    rdfs:domain biolink:MolecularEntity ;
    rdfs:range biolink:Drug ;
    rdfs:subPropertyOf biolink:part_of ;
    owl:inverseOf biolink:has_active_ingredient ;
    skos:definition "holds between a molecular entity and a drug, in which the former is a part of the latter, and is a biologically active component" ;
    skos:exactMatch RO:0002249 .

biolink:is_assessed_by a owl:ObjectProperty ;
    rdfs:label "is assessed by" ;
    rdfs:domain biolink:NamedThing ;
    rdfs:range biolink:NamedThing ;
    rdfs:subPropertyOf biolink:related_to_at_instance_level ;
    owl:inverseOf biolink:assesses .

biolink:is_diagnosed_by a owl:ObjectProperty ;
    rdfs:label "is diagnosed by" ;
    rdfs:domain biolink:DiseaseOrPhenotypicFeature ;
    rdfs:range biolink:ChemicalOrDrugOrTreatment ;
    rdfs:subPropertyOf biolink:related_to_at_instance_level ;
    owl:inverseOf biolink:diagnoses .

biolink:is_exacerbated_by a owl:ObjectProperty ;
    rdfs:label "is exacerbated by" ;
    rdfs:domain biolink:DiseaseOrPhenotypicFeature ;
    rdfs:range biolink:BiologicalEntity ;
    rdfs:subPropertyOf biolink:affected_by ;
    owl:inverseOf biolink:exacerbates .

biolink:is_excipient_of a owl:ObjectProperty ;
    rdfs:label "is excipient of" ;
    rdfs:domain biolink:MolecularEntity ;
    rdfs:range biolink:Drug ;
    rdfs:subPropertyOf biolink:part_of ;
    owl:inverseOf biolink:has_excipient ;
    skos:definition "holds between a molecular entity and a drug in which the former is a part of the latter, and is a biologically inactive component" ;
    skos:exactMatch WIKIDATA:Q902638 .

biolink:is_frameshift_variant_of a owl:ObjectProperty ;
    rdfs:label "is frameshift variant of" ;
    rdfs:domain biolink:SequenceVariant ;
    rdfs:range biolink:GenomicEntity ;
    rdfs:subPropertyOf biolink:is_sequence_variant_of ;
    owl:inverseOf biolink:has_frameshift_variant ;
    skos:altLabel "frameshift variant",
        "start lost",
        "stop lost" ;
    skos:definition "holds between a sequence variant and a gene, such the sequence variant causes a disruption of the translational reading frame, because the number of nucleotides inserted or deleted is not a multiple of three." ;
    skos:exactMatch <http://purl.obolibrary.org/obo/SO_0001589> ;
    biolink:canonical_predicate "True" .

biolink:is_metabolite a owl:ObjectProperty ;
    rdfs:label "is metabolite" ;
    rdfs:domain biolink:MolecularEntity ;
    rdfs:range linkml:Boolean ;
    rdfs:subPropertyOf biolink:node_property ;
    skos:definition "indicates whether a molecular entity is a metabolite" ;
    skos:exactMatch <http://purl.obolibrary.org/obo/CHEBI_25212> .

biolink:is_metabolite_of a owl:ObjectProperty ;
    rdfs:label "is metabolite of" ;
    rdfs:domain biolink:MolecularEntity ;
    rdfs:range biolink:MolecularEntity ;
    rdfs:subPropertyOf biolink:derives_from ;
    owl:inverseOf biolink:has_metabolite ;
    skos:definition "holds between two molecular entities in which the first one is derived from the second one as a product of metabolism" ;
    skos:exactMatch <http://purl.obolibrary.org/obo/CHEBI_25212> ;
    skos:note "The CHEBI ID represents a role rather than a predicate" .

biolink:is_missense_variant_of a owl:ObjectProperty ;
    rdfs:label "is missense variant of" ;
    rdfs:domain biolink:SequenceVariant ;
    rdfs:range biolink:GenomicEntity ;
    rdfs:subPropertyOf biolink:is_sequence_variant_of ;
    owl:inverseOf biolink:has_missense_variant ;
    skos:definition "holds between a gene  and a sequence variant, such the sequence variant results in a different amino acid sequence but where the length is preserved." ;
    skos:exactMatch <http://purl.obolibrary.org/obo/SO_0001583> ;
    biolink:canonical_predicate "True" .

biolink:is_molecular_consequence_of a owl:ObjectProperty ;
    rdfs:label "is molecular consequence of" ;
    rdfs:domain biolink:OntologyClass ;
    rdfs:range biolink:NamedThing ;
    rdfs:subPropertyOf biolink:related_to_at_instance_level ;
    owl:inverseOf biolink:has_molecular_consequence .

biolink:is_nearby_variant_of a owl:ObjectProperty ;
    rdfs:label "is nearby variant of" ;
    rdfs:domain biolink:SequenceVariant ;
    rdfs:range biolink:GenomicEntity ;
    rdfs:subPropertyOf biolink:is_sequence_variant_of ;
    owl:inverseOf biolink:has_nearby_variant ;
    skos:definition "holds between a sequence variant and a gene sequence that the variant is genomically close to." ;
    biolink:canonical_predicate "True" .

biolink:is_non_coding_variant_of a owl:ObjectProperty ;
    rdfs:label "is non coding variant of" ;
    rdfs:domain biolink:SequenceVariant ;
    rdfs:range biolink:GenomicEntity ;
    rdfs:subPropertyOf biolink:is_sequence_variant_of ;
    owl:inverseOf biolink:has_non_coding_variant ;
    skos:definition "holds between a sequence variant and a gene, where the variant does not affect the coding sequence" ;
    biolink:canonical_predicate "True" .

biolink:is_nonsense_variant_of a owl:ObjectProperty ;
    rdfs:label "is nonsense variant of" ;
    rdfs:domain biolink:SequenceVariant ;
    rdfs:range biolink:GenomicEntity ;
    rdfs:subPropertyOf biolink:is_sequence_variant_of ;
    owl:inverseOf biolink:has_nonsense_variant ;
    skos:broadMatch <http://purl.obolibrary.org/obo/SO_0002054> ;
    skos:definition "holds between a sequence variant and a gene, such the sequence variant results in a premature stop codon" ;
    biolink:canonical_predicate "True" .

biolink:is_output_of a owl:ObjectProperty ;
    rdfs:label "is output of" ;
    rdfs:domain biolink:Occurrent ;
    rdfs:range biolink:BiologicalProcessOrActivity ;
    rdfs:subPropertyOf biolink:participates_in ;
    owl:inverseOf biolink:has_output .

biolink:is_side_effect_of a owl:ObjectProperty ;
    rdfs:label "is side effect of" ;
    rdfs:domain biolink:DiseaseOrPhenotypicFeature ;
    rdfs:range biolink:ChemicalOrDrugOrTreatment ;
    rdfs:subPropertyOf biolink:affected_by ;
    owl:inverseOf biolink:has_side_effect .

biolink:is_splice_site_variant_of a owl:ObjectProperty ;
    rdfs:label "is splice site variant of" ;
    rdfs:domain biolink:SequenceVariant ;
    rdfs:range biolink:GenomicEntity ;
    rdfs:subPropertyOf biolink:is_sequence_variant_of ;
    owl:inverseOf biolink:has_splice_site_variant ;
    skos:definition "holds between a sequence variant and a gene, such the sequence variant is in the canonical splice site of one of the gene's exons." ;
    skos:exactMatch <http://purl.obolibrary.org/obo/SO_0001629> ;
    biolink:canonical_predicate "True" .

biolink:is_substrate_of a owl:ObjectProperty ;
    rdfs:label "is substrate of" ;
    rdfs:domain biolink:ChemicalEntityOrGeneOrGeneProduct ;
    rdfs:range biolink:MolecularActivity ;
    rdfs:subPropertyOf biolink:participates_in ;
    owl:inverseOf biolink:has_substrate .

biolink:is_supplement a owl:ObjectProperty ;
    rdfs:label "is supplement" ;
    rdfs:domain biolink:NamedThing ;
    rdfs:range biolink:ChemicalMixture ;
    rdfs:subPropertyOf biolink:node_property ;
    skos:definition "" .

biolink:is_synonymous_variant_of a owl:ObjectProperty ;
    rdfs:label "is synonymous variant of" ;
    rdfs:domain biolink:SequenceVariant ;
    rdfs:range biolink:GenomicEntity ;
    rdfs:subPropertyOf biolink:is_sequence_variant_of ;
    owl:inverseOf biolink:has_synonymous_variant ;
    skos:definition "holds between a sequence variant and a gene, such the sequence variant is in the coding sequence of the gene, but results in the same amino acid sequence" ;
    skos:exactMatch <http://purl.obolibrary.org/obo/SO_0001819> ;
    biolink:canonical_predicate "True" .

biolink:is_toxic a owl:ObjectProperty ;
    rdfs:label "is toxic" ;
    rdfs:domain biolink:NamedThing ;
    rdfs:range linkml:Boolean ;
    rdfs:subPropertyOf biolink:node_property ;
    skos:definition "" .

biolink:keywords a owl:ObjectProperty ;
    rdfs:label "keywords" ;
    rdfs:domain biolink:Publication ;
    rdfs:range linkml:String ;
    rdfs:subPropertyOf biolink:node_property ;
    skos:definition "keywords tagging a publication" .

biolink:lacks_part a owl:ObjectProperty ;
    rdfs:label "lacks part" ;
    rdfs:domain biolink:NamedThing ;
    rdfs:range biolink:NamedThing ;
    rdfs:subPropertyOf biolink:related_to_at_instance_level ;
    owl:inverseOf biolink:missing_from ;
    skos:exactMatch <http://purl.obolibrary.org/obo/CL_lacks_part>,
        <http://purl.obolibrary.org/obo/PR_lacks_part> ;
    skos:narrowMatch <http://purl.obolibrary.org/obo/CL_lacks_plasma_membrane_part> ;
    biolink:canonical_predicate "True" ;
    biolink:opposite_of "has part" .

biolink:latitude a owl:ObjectProperty ;
    rdfs:label "latitude" ;
    rdfs:domain biolink:NamedThing ;
    rdfs:range linkml:Float ;
    rdfs:subPropertyOf biolink:node_property ;
    skos:definition "latitude" ;
    skos:exactMatch wgs:lat .

biolink:license a owl:ObjectProperty ;
    rdfs:label "license" ;
    rdfs:domain biolink:InformationContentEntity ;
    rdfs:range linkml:String ;
    rdfs:subPropertyOf biolink:node_property ;
    skos:exactMatch dct:license ;
    skos:narrowMatch WIKIDATA_PROPERTY:P275 .

biolink:location_of_disease a owl:ObjectProperty ;
    rdfs:label "location of disease" ;
    rdfs:domain biolink:NamedThing ;
    rdfs:range biolink:NamedThing ;
    rdfs:subPropertyOf biolink:related_to ;
    owl:inverseOf biolink:disease_has_location .

biolink:longitude a owl:ObjectProperty ;
    rdfs:label "longitude" ;
    rdfs:domain biolink:NamedThing ;
    rdfs:range linkml:Float ;
    rdfs:subPropertyOf biolink:node_property ;
    skos:definition "longitude" ;
    skos:exactMatch wgs:long .

biolink:mapped_predicate a owl:ObjectProperty ;
    rdfs:label "mapped predicate" ;
    rdfs:range linkml:String ;
    skos:definition "The predicate that is being replaced by the fully qualified representation of predicate + subject and object  qualifiers.  Only to be used in test data and mapping data to help with the transition to the fully qualified predicate model. Not to be used in knowledge graphs." .

biolink:max_tolerated_dose a owl:ObjectProperty ;
    rdfs:label "max tolerated dose" ;
    rdfs:domain biolink:NamedThing ;
    rdfs:range linkml:String ;
    rdfs:subPropertyOf biolink:node_property ;
    skos:definition "The highest dose of a drug or treatment that does not cause unacceptable side effects. The maximum tolerated dose is determined in clinical trials by testing increasing doses on different groups of people until the highest dose with acceptable side effects is found. Also called MTD." .

biolink:member_of a owl:ObjectProperty ;
    rdfs:label "member of" ;
    rdfs:domain biolink:NamedThing ;
    rdfs:range biolink:NamedThing ;
    rdfs:subPropertyOf biolink:related_to_at_concept_level ;
    owl:inverseOf biolink:has_member ;
    skos:closeMatch skos:member ;
    skos:definition "Defines a mereological relation between a item and a collection." ;
    skos:exactMatch RO:0002350 .

biolink:mentioned_by a owl:ObjectProperty ;
    rdfs:label "mentioned by" ;
    rdfs:domain biolink:NamedThing ;
    rdfs:range biolink:NamedThing ;
    rdfs:subPropertyOf biolink:related_to_at_instance_level ;
    owl:inverseOf biolink:mentions ;
    skos:definition "refers to is a relation between one named thing and the information content entity that it makes reference to." .

biolink:mentions a owl:ObjectProperty ;
    rdfs:label "mentions" ;
    rdfs:domain biolink:NamedThing ;
    rdfs:range biolink:NamedThing ;
    rdfs:subPropertyOf biolink:related_to_at_instance_level ;
    owl:inverseOf biolink:mentioned_by ;
    skos:definition "refers to is a relation between one information content entity and the named thing that it makes reference to." ;
    skos:exactMatch IAO:0000142 ;
    skos:narrowMatch SIO:000628 .

biolink:mesh_terms a owl:ObjectProperty ;
    rdfs:label "mesh terms" ;
    rdfs:domain biolink:Publication ;
    rdfs:range linkml:Uriorcurie ;
    rdfs:subPropertyOf biolink:node_property ;
    skos:definition "mesh terms tagging a publication" ;
    skos:exactMatch dcid:MeSHTerm .

biolink:missing_from a owl:ObjectProperty ;
    rdfs:label "missing from" ;
    rdfs:domain biolink:NamedThing ;
    rdfs:range biolink:NamedThing ;
    rdfs:subPropertyOf biolink:related_to_at_instance_level ;
    owl:inverseOf biolink:lacks_part .

biolink:mode_of_inheritance_of a owl:ObjectProperty ;
    rdfs:label "mode of inheritance of" ;
    rdfs:domain biolink:GeneticInheritance ;
    rdfs:range biolink:DiseaseOrPhenotypicFeature ;
    rdfs:subPropertyOf biolink:manifestation_of ;
    owl:inverseOf biolink:has_mode_of_inheritance .

biolink:model_of a owl:ObjectProperty ;
    rdfs:label "model of" ;
    rdfs:domain biolink:NamedThing ;
    rdfs:range biolink:NamedThing ;
    rdfs:subPropertyOf biolink:related_to_at_instance_level ;
    owl:inverseOf biolink:models ;
    skos:definition "holds between a thing and some other thing it approximates for purposes of scientific study, in virtue of its exhibiting similar features of the studied entity." ;
    skos:exactMatch RO:0003301 ;
    skos:narrowMatch <http://purl.obolibrary.org/obo/FOODON_00001301> ;
    biolink:canonical_predicate "True" .

biolink:models a owl:ObjectProperty ;
    rdfs:label "models" ;
    rdfs:domain biolink:NamedThing ;
    rdfs:range biolink:NamedThing ;
    rdfs:subPropertyOf biolink:related_to_at_instance_level ;
    owl:inverseOf biolink:model_of .

biolink:negated a owl:ObjectProperty ;
    rdfs:label "negated" ;
    rdfs:domain biolink:Association ;
    rdfs:range linkml:Boolean ;
    rdfs:subPropertyOf biolink:association_slot ;
    skos:definition "if set to true, then the association is negated i.e. is not true" .

biolink:not_completed_by a owl:ObjectProperty ;
    rdfs:label "not completed by" ;
    rdfs:domain biolink:NamedThing ;
    rdfs:range biolink:NamedThing ;
    rdfs:subPropertyOf biolink:related_to_at_instance_level ;
    owl:inverseOf biolink:has_not_completed .

biolink:nutrient_of a owl:ObjectProperty ;
    rdfs:label "nutrient of" ;
    rdfs:domain biolink:ChemicalEntity ;
    rdfs:range biolink:ChemicalEntity ;
    rdfs:subPropertyOf biolink:food_component_of ;
    owl:inverseOf biolink:has_nutrient ;
    skos:definition "holds between a one or more chemical entities present in food, irrespective of nutritional value (i.e. could also be a contaminant or additive)" .

biolink:object_derivative_qualifier a owl:ObjectProperty ;
    rdfs:label "object derivative qualifier" ;
    rdfs:domain biolink:Association ;
    rdfs:range linkml:String ;
    rdfs:subPropertyOf biolink:derivative_qualifier .

biolink:occurs_in a owl:ObjectProperty ;
    rdfs:label "occurs in" ;
    rdfs:domain biolink:NamedThing ;
    rdfs:range biolink:NamedThing ;
    rdfs:subPropertyOf biolink:related_to_at_instance_level ;
    owl:inverseOf biolink:contains_process ;
    skos:closeMatch <http://purl.obolibrary.org/obo/BFO_0000067>,
        <http://purl.obolibrary.org/obo/SNOMED_has_occurrence>,
        <http://purl.obolibrary.org/obo/UBERON_site_of> ;
    skos:definition "holds between a process and a material entity or site within which the process occurs" ;
    skos:exactMatch <http://purl.obolibrary.org/obo/BFO_0000066>,
        <http://purl.obolibrary.org/obo/SNOMED_occurs_in>,
        PathWhiz:has_location ;
    skos:narrowMatch LOINC:has_imaged_location,
        RO:0002231,
        RO:0002232,
        <http://purl.obolibrary.org/obo/SNOMED_has_direct_procedure_site>,
        <http://purl.obolibrary.org/obo/SNOMED_has_direct_site>,
        <http://purl.obolibrary.org/obo/SNOMED_has_procedure_site>,
        UBERON_CORE:site_of,
        PathWhiz:in_species,
        SEMMEDDB:OCCURS_IN,
        SEMMEDDB:PROCESS_OF ;
    biolink:canonical_predicate "True" .

biolink:occurs_in_disease a owl:ObjectProperty ;
    rdfs:label "occurs in disease" ;
    rdfs:domain biolink:NamedThing ;
    rdfs:range biolink:NamedThing ;
    rdfs:subPropertyOf biolink:related_to_at_instance_level ;
    owl:inverseOf biolink:disease_has_basis_in .

biolink:original_object a owl:ObjectProperty ;
    rdfs:label "original object" ;
    rdfs:domain biolink:Association ;
    rdfs:range linkml:String ;
    rdfs:subPropertyOf biolink:association_slot ;
    skos:definition "used to hold the original object of a relation (or predicate) that an external knowledge source uses before transformation to match the biolink-model specification." .

biolink:original_predicate a owl:ObjectProperty ;
    rdfs:label "original predicate" ;
    rdfs:domain biolink:Association ;
    rdfs:range linkml:Uriorcurie ;
    rdfs:subPropertyOf biolink:association_slot ;
    skos:altLabel "original relation",
        "relation" ;
    skos:definition "used to hold the original relation/predicate that an external knowledge source uses before transformation to match the biolink-model specification." .

biolink:original_subject a owl:ObjectProperty ;
    rdfs:label "original subject" ;
    rdfs:domain biolink:Association ;
    rdfs:range linkml:String ;
    rdfs:subPropertyOf biolink:association_slot ;
    skos:definition "used to hold the original subject of a relation (or predicate) that an external knowledge source uses before transformation to match the biolink-model specification." .

biolink:p_value a owl:ObjectProperty ;
    rdfs:label "p value" ;
    rdfs:domain biolink:Association ;
    rdfs:range linkml:Float ;
    rdfs:subPropertyOf biolink:association_slot ;
    skos:altLabel "unadjusted p value" ;
    skos:definition "A quantitative confidence value that represents the probability of obtaining a result at least as extreme as that actually obtained, assuming that the actual value was the result of chance alone." ;
    skos:exactMatch EDAM-DATA:1669,
        <http://purl.obolibrary.org/obo/NCIT_C44185>,
        <http://purl.obolibrary.org/obo/OBI_0000175> .

biolink:pages a owl:ObjectProperty ;
    rdfs:label "pages" ;
    rdfs:domain biolink:Publication ;
    rdfs:range linkml:String ;
    rdfs:subPropertyOf biolink:node_property ;
    skos:definition "page number of source referenced for statement or publication" ;
    skos:exactMatch WIKIDATA_PROPERTY:P304 .

biolink:phase a owl:ObjectProperty ;
    rdfs:label "phase" ;
    rdfs:domain biolink:CodingSequence ;
    rdfs:range biolink:PhaseEnum ;
    rdfs:subPropertyOf biolink:sequence_localization_attribute ;
    skos:definition "The phase for a coding sequence entity. For example, phase of a CDS as represented in a GFF3 with a value of 0, 1 or 2." ;
    skos:exactMatch gff3:phase .

biolink:phenotype_of a owl:ObjectProperty ;
    rdfs:label "phenotype of" ;
    rdfs:domain biolink:PhenotypicFeature ;
    rdfs:range biolink:BiologicalEntity ;
    rdfs:subPropertyOf biolink:related_to_at_instance_level ;
    owl:inverseOf biolink:has_phenotype .

biolink:plasma_membrane_part_of a owl:ObjectProperty ;
    rdfs:label "plasma membrane part of" ;
    rdfs:domain biolink:NamedThing ;
    rdfs:range biolink:NamedThing ;
    rdfs:subPropertyOf biolink:part_of ;
    owl:inverseOf biolink:has_plasma_membrane_part .

biolink:population_context_qualifier a owl:ObjectProperty ;
    rdfs:label "population context qualifier" ;
    rdfs:domain biolink:Association ;
    rdfs:range biolink:PopulationOfIndividualOrganisms ;
    rdfs:subPropertyOf biolink:qualifier ;
    skos:definition "a biological population (general, study, cohort, etc.) with a specific set of characteristics to constrain an association." .

biolink:preceded_by a owl:ObjectProperty ;
    rdfs:label "preceded by" ;
    rdfs:domain biolink:Occurrent ;
    rdfs:range biolink:Occurrent ;
    rdfs:subPropertyOf biolink:temporally_related_to ;
    owl:inverseOf biolink:precedes ;
    skos:broadMatch <http://purl.obolibrary.org/obo/GENEPIO_0001739> ;
    skos:definition "holds between two processes, where the other is completed before the one begins" ;
    skos:exactMatch <http://purl.obolibrary.org/obo/BFO_0000062> ;
    skos:narrowMatch <http://purl.obolibrary.org/obo/FMA_transforms_from>,
        RO:0002087,
        RO:0002285 .

biolink:precedes a owl:ObjectProperty ;
    rdfs:label "precedes" ;
    rdfs:domain biolink:Occurrent ;
    rdfs:range biolink:Occurrent ;
    rdfs:subPropertyOf biolink:temporally_related_to ;
    owl:inverseOf biolink:preceded_by ;
    skos:broadMatch WIKIDATA_PROPERTY:P156 ;
    skos:closeMatch RO:0002263,
        RO:0002264 ;
    skos:definition "holds between two processes, where one completes before the other begins" ;
    skos:exactMatch <http://purl.obolibrary.org/obo/BFO_0000063>,
        <http://purl.obolibrary.org/obo/SNOMED_occurs_before>,
        SEMMEDDB:PRECEDES ;
    skos:narrowMatch <http://purl.obolibrary.org/obo/FMA_transforms_into>,
        RO:0002090,
        RO:0002411,
        RO:0002412 ;
    biolink:canonical_predicate "True" .

biolink:predicate_mappings a owl:ObjectProperty ;
    rdfs:label "predicate mappings" ;
    rdfs:range biolink:PredicateMapping ;
    skos:definition "A collection of relationships that are not used in biolink, but have biolink patterns that can  be used to replace them.  This is a temporary slot to help with the transition to the fully qualified predicate model in Biolink3." .

biolink:predisposes a owl:ObjectProperty ;
    rdfs:label "predisposes" ;
    rdfs:domain biolink:NamedThing ;
    rdfs:range biolink:NamedThing ;
    rdfs:subPropertyOf biolink:affects_risk_for ;
    owl:inverseOf biolink:has_predisposing_factor ;
    skos:definition "holds between two entities where exposure to one entity increases the chance of developing the other" ;
    skos:exactMatch SEMMEDDB:PREDISPOSES ;
    biolink:canonical_predicate "True" ;
    biolink:opposite_of "prevents" .

biolink:prevented_by a owl:ObjectProperty ;
    rdfs:label "prevented by" ;
    rdfs:domain biolink:NamedThing ;
    rdfs:range biolink:NamedThing ;
    rdfs:subPropertyOf biolink:risk_affected_by ;
    owl:inverseOf biolink:prevents ;
    skos:definition "holds between a potential outcome of which the likelihood was reduced by the application or use of an entity." ;
    biolink:opposite_of "enabled by" .

biolink:prevents a owl:ObjectProperty ;
    rdfs:label "prevents" ;
    rdfs:domain biolink:NamedThing ;
    rdfs:range biolink:NamedThing ;
    rdfs:subPropertyOf biolink:affects_risk_for ;
    owl:inverseOf biolink:prevented_by ;
    skos:definition "holds between an entity whose application or use reduces the likelihood of a potential outcome. Typically used to associate a chemical entity, exposure, activity, or medical intervention that can prevent the onset a disease or phenotypic feature." ;
    skos:exactMatch SEMMEDDB:PREVENTS ;
    skos:narrowMatch RO:0002599 ;
    biolink:canonical_predicate "True" ;
    biolink:opposite_of "predisposes" .

biolink:primarily_composed_of a owl:ObjectProperty ;
    rdfs:label "primarily composed of" ;
    rdfs:domain biolink:NamedThing ;
    rdfs:range biolink:NamedThing ;
    rdfs:subPropertyOf biolink:related_to ;
    owl:inverseOf biolink:composed_primarily_of .

biolink:primary_knowledge_source a owl:ObjectProperty ;
    rdfs:label "primary knowledge source" ;
    rdfs:domain biolink:Association ;
    rdfs:range biolink:InformationResource ;
    rdfs:subPropertyOf biolink:knowledge_source ;
    skos:definition "The most upstream source of the knowledge expressed in an Association that an implementer can identify.  Performing a rigorous analysis of upstream data providers is expected; every effort is made to catalog the most upstream source of data in this property.  Only one data source should be declared primary in any association.  \"aggregator knowledge source\" can be used to caputre non-primary sources." ;
    skos:editorialNote "For example: a single ChemicalToGene Edge originally curated by ClinicalTrials.org, is aggregated by ChEMBL, then  incorporated into the MolePro KP, then sent via TRAPI message to the ARAGORN ARA, and finally sent to  the NCATS ARS. The retrieval path for this Edge is as follows:  ARS--retrieved_from-->  ARAGORN  --retrieved_from-->   MolePro  --retrieved_from--> ChEMBL --retrieved_from-->  ClinicalTrials.gov The \"primary knowledge source\" for this edge is \"infores:clinical-trials-gov\".  \"infores:chembl\" and \"infores:molecular_data_provider\" are listed in the \"aggregator knowledge source\" property." .

biolink:produced_by a owl:ObjectProperty ;
    rdfs:label "produced by" ;
    rdfs:domain biolink:NamedThing ;
    rdfs:range biolink:NamedThing ;
    rdfs:subPropertyOf biolink:related_to_at_instance_level ;
    owl:inverseOf biolink:produces ;
    skos:exactMatch RO:0003001 .

biolink:produces a owl:ObjectProperty ;
    rdfs:label "produces" ;
    rdfs:domain biolink:NamedThing ;
    rdfs:range biolink:NamedThing ;
    rdfs:subPropertyOf biolink:related_to_at_instance_level ;
    owl:inverseOf biolink:produced_by ;
    skos:definition "holds between a material entity and a product that is generated through the intentional actions or functioning of the material entity" ;
    skos:exactMatch RO:0003000,
        SEMMEDDB:PRODUCES,
        WIKIDATA_PROPERTY:P1056 ;
    skos:narrowMatch <http://purl.obolibrary.org/obo/NCIT_R29>,
        <http://purl.obolibrary.org/obo/SNOMED_has_process_output>,
        <http://purl.obolibrary.org/obo/SNOMED_specimen_procedure_of> ;
    skos:relatedMatch GOREL:0001010 ;
    biolink:canonical_predicate "True" .

biolink:provided_by a owl:ObjectProperty ;
    rdfs:label "provided by" ;
    rdfs:domain biolink:NamedThing ;
    rdfs:range linkml:String ;
    rdfs:subPropertyOf biolink:node_property ;
    skos:definition "The value in this node property represents the knowledge provider that created or assembled the node and all of its attributes.  Used internally to represent how a particular node made its way into a knowledge provider or graph." .

biolink:provider a owl:ObjectProperty ;
    rdfs:label "provider" ;
    rdfs:domain biolink:Agent ;
    rdfs:range biolink:InformationContentEntity ;
    rdfs:subPropertyOf biolink:contributor ;
    owl:inverseOf biolink:has_provider ;
    skos:definition "person, group, organization or project that provides a piece of information (e.g. a knowledge association)." .

biolink:publications a owl:ObjectProperty ;
    rdfs:label "publications" ;
    rdfs:domain biolink:Association ;
    rdfs:range biolink:Publication ;
    rdfs:subPropertyOf biolink:supporting_documents ;
    skos:altLabel "supporting publications" ;
    skos:definition "One or more publications that report the statement expressed in an Association, or provide information used as  evidence supporting this statement." .

biolink:publisher a owl:ObjectProperty ;
    rdfs:label "publisher" ;
    rdfs:domain biolink:Agent ;
    rdfs:range biolink:Publication ;
    rdfs:subPropertyOf biolink:contributor ;
    owl:inverseOf biolink:has_publisher ;
    skos:definition "organization or person responsible for publishing books, periodicals, podcasts, games or software. Note that in the case of publications which have a containing \"published in\" node property, the publisher association may not be attached directly to the embedded child publication, but only made in between the parent's publication node and the publisher agent of the encompassing publication (e.g. only from the Journal referenced by the 'published_in' property of an journal article Publication node)." ;
    skos:exactMatch dct:publisher,
        WIKIDATA_PROPERTY:P123 .

biolink:reaction_direction a owl:ObjectProperty ;
    rdfs:label "reaction direction" ;
    rdfs:domain biolink:Association ;
    rdfs:range biolink:ReactionDirectionEnum ;
    rdfs:subPropertyOf biolink:association_slot ;
    skos:definition "the direction of a reaction as constrained by the direction enum (ie: left_to_right, neutral, etc.)" ;
    skos:narrowMatch <http://purl.obolibrary.org/obo/NCIT_C42677> .

biolink:reaction_side a owl:ObjectProperty ;
    rdfs:label "reaction side" ;
    rdfs:domain biolink:Association ;
    rdfs:range biolink:ReactionSideEnum ;
    rdfs:subPropertyOf biolink:association_slot ;
    skos:definition "the side of a reaction being modeled (ie: left or right)" .

biolink:regulated_by a owl:ObjectProperty ;
    rdfs:label "regulated by" ;
    rdfs:domain biolink:PhysicalEssenceOrOccurrent ;
    rdfs:range biolink:PhysicalEssenceOrOccurrent ;
    rdfs:subPropertyOf biolink:affected_by ;
    owl:inverseOf biolink:regulates .

biolink:regulates a owl:ObjectProperty ;
    rdfs:label "regulates" ;
    rdfs:domain biolink:PhysicalEssenceOrOccurrent ;
    rdfs:range biolink:PhysicalEssenceOrOccurrent ;
    rdfs:subPropertyOf biolink:affects,
        biolink:interacts_with ;
    owl:inverseOf biolink:regulated_by ;
    skos:broadMatch RO:0002295,
        RO:0002332,
        RO:0002448,
        CHEMBL.MECHANISM:modulator,
        WIKIDATA_PROPERTY:P128 ;
    skos:definition "A more specific form of affects, that implies the effect results from a biologically evolved control mechanism. Gene-affects-gene relationships will (almost) always involve regulation.  Exogenous/environmental chemical-affects-gene relationships  are not cases of regulation in this definition. Instead these would be captured using the 'affects' predicate, or possibly one of the 'interacts with' predicates depending on the nature of the interaction." ;
    skos:editorialNote "The RO definition of 'directly regulates the activity of' is an exact_mapping here because  it describes genetic regulation from the point of view of one genetic entity regulating another, as opposed to \"RO:0002211\" which describes process to process regulation." ;
    skos:exactMatch RO:0002448 ;
    biolink:canonical_predicate "True" .

biolink:resistance_associated_with a owl:ObjectProperty ;
    rdfs:label "resistance associated with" ;
    rdfs:domain biolink:ChemicalEntity ;
    rdfs:range biolink:NamedThing ;
    rdfs:subPropertyOf biolink:associated_with ;
    owl:inverseOf biolink:associated_with_resistance_to .

biolink:response_decreased_by a owl:ObjectProperty ;
    rdfs:label "response decreased by" ;
    rdfs:domain biolink:ChemicalEntityOrGeneOrGeneProduct ;
    rdfs:range biolink:ChemicalEntityOrGeneOrGeneProduct ;
    rdfs:subPropertyOf biolink:response_affected_by ;
    owl:inverseOf biolink:decreases_response_to .

biolink:response_increased_by a owl:ObjectProperty ;
    rdfs:label "response increased by" ;
    rdfs:domain biolink:ChemicalEntityOrGeneOrGeneProduct ;
    rdfs:range biolink:ChemicalEntityOrGeneOrGeneProduct ;
    rdfs:subPropertyOf biolink:response_affected_by ;
    owl:inverseOf biolink:increases_response_to .

biolink:rights a owl:ObjectProperty ;
    rdfs:label "rights" ;
    rdfs:domain biolink:InformationContentEntity ;
    rdfs:range linkml:String ;
    rdfs:subPropertyOf biolink:node_property ;
    skos:exactMatch dct:rights .

biolink:routes_of_delivery a owl:ObjectProperty ;
    rdfs:label "routes of delivery" ;
    rdfs:range biolink:DrugDeliveryEnum ;
    skos:definition "the method or process of administering a pharmaceutical compound to achieve a therapeutic effect in humans or animals." .

biolink:sensitivity_associated_with a owl:ObjectProperty ;
    rdfs:label "sensitivity associated with" ;
    rdfs:domain biolink:ChemicalEntity ;
    rdfs:range biolink:NamedThing ;
    rdfs:subPropertyOf biolink:associated_with ;
    owl:inverseOf biolink:associated_with_sensitivity_to .

biolink:sequence_location_of a owl:ObjectProperty ;
    rdfs:label "sequence location of" ;
    rdfs:domain biolink:NucleicAcidEntity ;
    rdfs:range biolink:NucleicAcidEntity ;
    rdfs:subPropertyOf biolink:related_to_at_instance_level ;
    owl:inverseOf biolink:has_sequence_location .

biolink:source_web_page a owl:ObjectProperty ;
    rdfs:label "source web page" ;
    rdfs:domain biolink:DatasetSummary ;
    rdfs:range linkml:String ;
    rdfs:subPropertyOf biolink:node_property ;
    skos:broadMatch dct:source .

biolink:start_interbase_coordinate a owl:ObjectProperty ;
    rdfs:label "start interbase coordinate" ;
    rdfs:domain biolink:GenomicSequenceLocalization ;
    rdfs:range linkml:Integer ;
    rdfs:subPropertyOf biolink:interbase_coordinate ;
    skos:closeMatch <http://biohackathon.org/resource/faldo#begin> ;
    skos:definition "The position at which the subject nucleic acid entity starts on the chromosome or other entity to which it is located on. (ie: the start of the sequence being referenced is 0)." ;
    biolink:opposite_of "end interbase coordinate" .

biolink:stoichiometry a owl:ObjectProperty ;
    rdfs:label "stoichiometry" ;
    rdfs:domain biolink:Association ;
    rdfs:range linkml:Integer ;
    rdfs:subPropertyOf biolink:association_slot ;
    skos:definition "the relationship between the relative quantities of substances taking part in a reaction or forming a compound, typically a ratio of whole integers." .

biolink:strand a owl:ObjectProperty ;
    rdfs:label "strand" ;
    rdfs:domain biolink:GenomicSequenceLocalization ;
    rdfs:range biolink:StrandEnum ;
    rdfs:subPropertyOf biolink:sequence_localization_attribute ;
    skos:definition "The strand on which a feature is located. Has a value of '+' (sense strand or forward strand) or '-' (anti-sense strand or reverse strand)." ;
    skos:exactMatch gff3:strand .

biolink:summary a owl:ObjectProperty ;
    rdfs:label "summary" ;
    rdfs:domain biolink:Publication ;
    rdfs:range linkml:String ;
    rdfs:subPropertyOf biolink:node_property ;
    skos:altLabel "abstract" ;
    skos:definition "executive  summary of a publication" ;
    skos:exactMatch dct:abstract,
        WIKIDATA:Q333291 .

biolink:supporting_documents a owl:ObjectProperty ;
    rdfs:label "supporting documents" ;
    rdfs:domain biolink:Association ;
    rdfs:range linkml:Uriorcurie ;
    rdfs:subPropertyOf biolink:association_slot ;
    skos:definition "One or more referencable documents that report the statement expressed in an Association, or provide  information used as evidence supporting this statement." ;
    linkml:examples "Example(value='PMID:12345678', description=None)" .

biolink:symbol a owl:ObjectProperty ;
    rdfs:label "symbol" ;
    rdfs:domain biolink:NamedThing ;
    rdfs:range linkml:String ;
    rdfs:subPropertyOf biolink:node_property ;
    skos:definition "Symbol for a particular thing" ;
    skos:exactMatch gpi:DB_Object_Symbol,
        AGRKB:symbol .

biolink:target_for a owl:ObjectProperty ;
    rdfs:label "target for" ;
    rdfs:domain biolink:Gene ;
    rdfs:range biolink:Disease ;
    rdfs:subPropertyOf biolink:related_to_at_instance_level ;
    owl:inverseOf biolink:has_target ;
    skos:definition "A gene is a target of a disease when its products are druggable and when a drug interaction with the gene product could have a therapeutic effect" ;
    biolink:canonical_predicate "True" .

biolink:taxon_of a owl:ObjectProperty ;
    rdfs:label "taxon of" ;
    rdfs:domain biolink:OrganismTaxon ;
    rdfs:range biolink:ThingWithTaxon ;
    rdfs:subPropertyOf biolink:related_to_at_instance_level ;
    owl:inverseOf biolink:in_taxon .

biolink:trade_name a owl:ObjectProperty ;
    rdfs:label "trade name" ;
    rdfs:domain biolink:NamedThing ;
    rdfs:range biolink:ChemicalEntity ;
    rdfs:subPropertyOf biolink:node_property ;
    skos:definition "" .

biolink:transcribed_from a owl:ObjectProperty ;
    rdfs:label "transcribed from" ;
    rdfs:domain biolink:Transcript ;
    rdfs:range biolink:Gene ;
    rdfs:subPropertyOf biolink:related_to_at_instance_level ;
    owl:inverseOf biolink:transcribed_to ;
    skos:definition "x is transcribed from y if and only if x is synthesized from template y" ;
    skos:exactMatch RO:0002510,
        SIO:010081 ;
    biolink:canonical_predicate "True" .

biolink:transcribed_to a owl:ObjectProperty ;
    rdfs:label "transcribed to" ;
    rdfs:domain biolink:Gene ;
    rdfs:range biolink:Transcript ;
    rdfs:subPropertyOf biolink:related_to_at_instance_level ;
    owl:inverseOf biolink:transcribed_from ;
    skos:definition "inverse of transcribed from" ;
    skos:exactMatch RO:0002511,
        SIO:010080 .

biolink:translates_to a owl:ObjectProperty ;
    rdfs:label "translates to" ;
    rdfs:domain biolink:Transcript ;
    rdfs:range biolink:Protein ;
    rdfs:subPropertyOf biolink:related_to_at_instance_level ;
    owl:inverseOf biolink:translation_of ;
    skos:closeMatch RO:0002513,
        SIO:010082 ;
    skos:definition "x (amino acid chain/polypeptide) is the ribosomal translation of y (transcript) if and only if a ribosome reads y (transcript) through a series of triplet codon-amino acid adaptor activities (GO:0030533) and produces x (amino acid chain/polypeptide)" ;
    biolink:canonical_predicate "True" .

biolink:translation_of a owl:ObjectProperty ;
    rdfs:label "translation of" ;
    rdfs:domain biolink:Protein ;
    rdfs:range biolink:Transcript ;
    rdfs:subPropertyOf biolink:related_to_at_instance_level ;
    owl:inverseOf biolink:translates_to ;
    skos:closeMatch RO:0002512,
        SIO:010083 ;
    skos:definition "inverse of translates to" .

biolink:treated_by a owl:ObjectProperty ;
    rdfs:label "treated by" ;
    rdfs:domain biolink:DiseaseOrPhenotypicFeature ;
    rdfs:range biolink:ChemicalOrDrugOrTreatment ;
    rdfs:subPropertyOf biolink:is_ameliorated_by ;
    owl:inverseOf biolink:treats ;
    skos:definition "holds between a disease or phenotypic feature and a therapeutic process or chemical entity that is used to treat the condition" ;
    skos:exactMatch <http://purl.obolibrary.org/obo/MONDO_disease_responds_to>,
        WIKIDATA_PROPERTY:P2176 ;
    skos:narrowMatch RO:0002302 .

biolink:treats a owl:ObjectProperty ;
    rdfs:label "treats" ;
    rdfs:domain biolink:ChemicalOrDrugOrTreatment ;
    rdfs:range biolink:DiseaseOrPhenotypicFeature ;
    rdfs:subPropertyOf biolink:ameliorates ;
    owl:inverseOf biolink:treated_by ;
    skos:altLabel "indicated for",
        "is substance that treats" ;
    skos:definition "holds between a therapeutic procedure or chemical entity and a disease or phenotypic feature that it is used to treat" ;
    skos:exactMatch <http://identifiers.org/drugbank/treats>,
        SEMMEDDB:TREATS,
        WIKIDATA_PROPERTY:P2175 ;
    skos:narrowMatch REPODB:clinically_tested_approved_unknown_phase,
        REPODB:clinically_tested_suspended_phase_0,
        REPODB:clinically_tested_suspended_phase_1,
        REPODB:clinically_tested_suspended_phase_1_or_phase_2,
        REPODB:clinically_tested_suspended_phase_2,
        REPODB:clinically_tested_suspended_phase_2_or_phase_3,
        REPODB:clinically_tested_suspended_phase_3,
        REPODB:clinically_tested_terminated_phase_0,
        REPODB:clinically_tested_terminated_phase_1,
        REPODB:clinically_tested_terminated_phase_1_or_phase_2,
        REPODB:clinically_tested_terminated_phase_2,
        REPODB:clinically_tested_terminated_phase_2_or_phase_3,
        REPODB:clinically_tested_terminated_phase_3,
        REPODB:clinically_tested_withdrawn_phase_0,
        REPODB:clinically_tested_withdrawn_phase_1,
        REPODB:clinically_tested_withdrawn_phase_1_or_phase_2,
        REPODB:clinically_tested_withdrawn_phase_2,
        REPODB:clinically_tested_withdrawn_phase_2_or_phase_3,
        REPODB:clinically_tested_withdrawn_phase_3,
        <http://purl.obolibrary.org/obo/NCIT_regimen_has_accepted_use_for_disease>,
        RO:0002606,
        <http://purl.obolibrary.org/obo/SNOMED_plays_role> ;
    skos:relatedMatch <http://purl.obolibrary.org/obo/MONDO_disease_responds_to> ;
    biolink:canonical_predicate "True" ;
    biolink:opposite_of "contraindicated for" .

biolink:variant_part_of a owl:ObjectProperty ;
    rdfs:label "variant part of" ;
    rdfs:domain biolink:NamedThing ;
    rdfs:range biolink:NamedThing ;
    rdfs:subPropertyOf biolink:part_of ;
    owl:inverseOf biolink:has_variant_part .

linkml:topValue a owl:DatatypeProperty ;
    rdfs:label "value" .

dct:description a owl:ObjectProperty ;
    rdfs:label "description" ;
    rdfs:range biolink:NarrativeText ;
    skos:altLabel "definition" ;
    skos:definition "a human-readable description of an entity" ;
    skos:exactMatch IAO:0000115,
        dct:description,
        skos:definitions ;
    skos:narrowMatch gff3:Description .

dct:distribution a owl:ObjectProperty ;
    rdfs:label "has distribution" ;
    rdfs:domain biolink:DatasetVersion ;
    rdfs:range biolink:DatasetDistribution ;
    rdfs:subPropertyOf biolink:node_property ;
    skos:exactMatch dct:distribution .

dct:type a owl:ObjectProperty ;
    rdfs:label "publication type" ;
    rdfs:range linkml:String ;
    skos:definition "Ontology term for publication type may be drawn from Dublin Core types (https://www.dublincore.org/specifications/dublin-core/dcmi-type-vocabulary/), FRBR-aligned Bibliographic Ontology (https://sparontologies.github.io/fabio/current/fabio.html), the MESH publication types (https://www.nlm.nih.gov/mesh/pubtypes.html), the Confederation of Open Access Repositories (COAR) Controlled Vocabulary for Resource Type Genres (http://vocabularies.coar-repositories.org/documentation/resource_types/), Wikidata (https://www.wikidata.org/wiki/Wikidata:Publication_types), or equivalent publication type ontology. When a given publication type ontology term is used within a given knowledge graph, then the CURIE identified term must be documented in the graph as a concept node of biolink:category biolink:OntologyClass." ;
    skos:exactMatch dct:type .

schema:logo a owl:ObjectProperty ;
    rdfs:label "source logo" ;
    rdfs:domain biolink:DatasetSummary ;
    rdfs:range linkml:String ;
    rdfs:subPropertyOf biolink:node_property ;
    skos:exactMatch schema:logo .

os:AllSomeInterpretation a owl:Class ;
    rdfs:label "all_some" .

os:SomeSomeInterpretation a owl:Class ;
    rdfs:label "some_some" .

biolink:AnatomicalContextQualifierEnum a owl:Class ;
    rdfs:label "AnatomicalContextQualifierEnum" ;
    owl:unionOf [ rdf:rest () ] .

biolink:AnatomicalEntityToAnatomicalEntityAssociation a owl:Class ;
    rdfs:label "anatomical entity to anatomical entity association" ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:onClass biolink:AnatomicalEntity ;
            owl:onProperty rdf:object ;
            owl:qualifiedCardinality 1 ],
        [ a owl:Restriction ;
            owl:onClass biolink:AnatomicalEntity ;
            owl:onProperty rdf:subject ;
            owl:qualifiedCardinality 1 ],
        biolink:Association .

biolink:Annotation a owl:Class ;
    rdfs:label "annotation" ;
    skos:definition "Biolink Model root class for entity annotations." .

biolink:CaseToEntityAssociationMixin a owl:Class ;
    rdfs:label "case to entity association mixin" ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:onClass biolink:Case ;
            owl:onProperty rdf:subject ;
            owl:qualifiedCardinality 1 ],
        linkml:mixin ;
    skos:definition "An abstract association for use where the case is the subject" .

<https://w3id.org/biolink/vocab/CausalMechanismQualifierEnum#activation> a owl:Class ;
    rdfs:label "activation" .

<https://w3id.org/biolink/vocab/CausalMechanismQualifierEnum#agonism> a owl:Class ;
    rdfs:label "agonism" .

<https://w3id.org/biolink/vocab/CausalMechanismQualifierEnum#antagonism> a owl:Class ;
    rdfs:label "antagonism" .

<https://w3id.org/biolink/vocab/CausalMechanismQualifierEnum#antibody_inhibition> a owl:Class ;
    rdfs:label "antibody_inhibition" .

<https://w3id.org/biolink/vocab/CausalMechanismQualifierEnum#binding> a owl:Class ;
    rdfs:label "binding" .

<https://w3id.org/biolink/vocab/CausalMechanismQualifierEnum#inducer> a owl:Class ;
    rdfs:label "inducer" .

<https://w3id.org/biolink/vocab/CausalMechanismQualifierEnum#inhibition> a owl:Class ;
    rdfs:label "inhibition" .

<https://w3id.org/biolink/vocab/CausalMechanismQualifierEnum#inverse_agonism> a owl:Class ;
    rdfs:label "inverse_agonism" .

<https://w3id.org/biolink/vocab/CausalMechanismQualifierEnum#molecular_channel_blockage> a owl:Class ;
    rdfs:label "molecular_channel_blockage" .

<https://w3id.org/biolink/vocab/CausalMechanismQualifierEnum#molecular_channel_opening> a owl:Class ;
    rdfs:label "molecular_channel_opening" .

<https://w3id.org/biolink/vocab/CausalMechanismQualifierEnum#negative_allosteric_modulation> a owl:Class ;
    rdfs:label "negative_allosteric_modulation" .

<https://w3id.org/biolink/vocab/CausalMechanismQualifierEnum#positive_allosteric_modulation> a owl:Class ;
    rdfs:label "positive_allosteric_modulation" .

<https://w3id.org/biolink/vocab/CausalMechanismQualifierEnum#potentiation> a owl:Class ;
    rdfs:label "potentiation" .

<https://w3id.org/biolink/vocab/CausalMechanismQualifierEnum#releasing_activity> a owl:Class ;
    rdfs:label "releasing_activity" .

<https://w3id.org/biolink/vocab/CausalMechanismQualifierEnum#signaling_mediated_control> a owl:Class ;
    rdfs:label "signaling_mediated_control" .

<https://w3id.org/biolink/vocab/CausalMechanismQualifierEnum#stabilization> a owl:Class ;
    rdfs:label "stabilization" .

<https://w3id.org/biolink/vocab/CausalMechanismQualifierEnum#stimulation> a owl:Class ;
    rdfs:label "stimulation" .

<https://w3id.org/biolink/vocab/CausalMechanismQualifierEnum#transcriptional_regulation> a owl:Class ;
    rdfs:label "transcriptional_regulation" .

biolink:CellLine a owl:Class ;
    rdfs:label "cell line" ;
    rdfs:subClassOf biolink:OrganismalEntity,
        biolink:SubjectOfInvestigation ;
    skos:exactMatch <http://purl.obolibrary.org/obo/CLO_0000031> .

biolink:CellLineToEntityAssociationMixin a owl:Class ;
    rdfs:label "cell line to entity association mixin" ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:onClass biolink:CellLine ;
            owl:onProperty rdf:subject ;
            owl:qualifiedCardinality 1 ],
        linkml:mixin ;
    skos:definition "An relationship between a cell line and another entity" .

biolink:ChemicalEntityDerivativeEnum a owl:Class ;
    rdfs:label "ChemicalEntityDerivativeEnum" ;
    owl:unionOf ( <https://w3id.org/biolink/vocab/ChemicalEntityDerivativeEnum#metabolite> ) ;
    linkml:permissible_values <https://w3id.org/biolink/vocab/ChemicalEntityDerivativeEnum#metabolite> .

<https://w3id.org/biolink/vocab/ChemicalEntityDerivativeEnum#metabolite> a owl:Class ;
    rdfs:label "metabolite" .

<https://w3id.org/biolink/vocab/ChemicalOrGeneOrGeneProductFormOrVariantEnum#analog_form> a owl:Class ;
    rdfs:label "analog_form" .

<https://w3id.org/biolink/vocab/ChemicalOrGeneOrGeneProductFormOrVariantEnum#gain_of_function_variant_form> a owl:Class ;
    rdfs:label "gain_of_function_variant_form" .

<https://w3id.org/biolink/vocab/ChemicalOrGeneOrGeneProductFormOrVariantEnum#genetic_variant_form> a owl:Class ;
    rdfs:label "genetic_variant_form" .

<https://w3id.org/biolink/vocab/ChemicalOrGeneOrGeneProductFormOrVariantEnum#loss_of_function_variant_form> a owl:Class ;
    rdfs:label "loss_of_function_variant_form" .

<https://w3id.org/biolink/vocab/ChemicalOrGeneOrGeneProductFormOrVariantEnum#modified_form> a owl:Class ;
    rdfs:label "modified_form" .

<https://w3id.org/biolink/vocab/ChemicalOrGeneOrGeneProductFormOrVariantEnum#polymorphic_form> a owl:Class ;
    rdfs:label "polymorphic_form" .

<https://w3id.org/biolink/vocab/ChemicalOrGeneOrGeneProductFormOrVariantEnum#snp_form> a owl:Class ;
    rdfs:label "snp_form" .

biolink:ChemicalRole a owl:Class ;
    rdfs:label "chemical role" ;
    rdfs:subClassOf biolink:Attribute ;
    skos:definition "	A role played by the molecular entity or part thereof within a chemical context." ;
    skos:exactMatch <http://purl.obolibrary.org/obo/CHEBI_51086> ;
    linkml:examples "Example(value='CHEBI:35469', description=None)" .

biolink:ChemicalToChemicalAssociation a owl:Class ;
    rdfs:label "chemical to chemical association" ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:onClass biolink:ChemicalEntity ;
            owl:onProperty rdf:object ;
            owl:qualifiedCardinality 1 ],
        biolink:Association,
        biolink:ChemicalToEntityAssociationMixin ;
    skos:definition "A relationship between two chemical entities. This can encompass actual interactions as well as temporal causal edges, e.g. one chemical converted to another." .

biolink:ClinicalEntity a owl:Class ;
    rdfs:label "clinical entity" ;
    rdfs:subClassOf biolink:NamedThing ;
    skos:definition "Any entity or process that exists in the clinical domain and outside the biological realm. Diseases are placed under biological entities" .

biolink:Device a owl:Class ;
    rdfs:label "device" ;
    rdfs:subClassOf biolink:NamedThing ;
    skos:definition "A thing made or adapted for a particular purpose, especially a piece of mechanical or electronic equipment" ;
    skos:narrowMatch STY:T074,
        STY:T075,
        STY:T122,
        STY:T203,
        UMLSSG:DEVI .

<https://w3id.org/biolink/vocab/DirectionQualifierEnum#decreased> a owl:Class ;
    rdfs:label "decreased" .

<https://w3id.org/biolink/vocab/DirectionQualifierEnum#downregulated> a owl:Class ;
    rdfs:label "downregulated" .

<https://w3id.org/biolink/vocab/DirectionQualifierEnum#increased> a owl:Class ;
    rdfs:label "increased" .

<https://w3id.org/biolink/vocab/DirectionQualifierEnum#upregulated> a owl:Class ;
    rdfs:label "upregulated" .

biolink:DrugAvailabilityEnum a owl:Class ;
    rdfs:label "DrugAvailabilityEnum" ;
    owl:unionOf ( <https://w3id.org/biolink/vocab/DrugAvailabilityEnum#over_the_counter> <https://w3id.org/biolink/vocab/DrugAvailabilityEnum#prescription> ) ;
    linkml:permissible_values <https://w3id.org/biolink/vocab/DrugAvailabilityEnum#over_the_counter>,
        <https://w3id.org/biolink/vocab/DrugAvailabilityEnum#prescription> .

<https://w3id.org/biolink/vocab/DrugAvailabilityEnum#over_the_counter> a owl:Class ;
    rdfs:label "over_the_counter" .

<https://w3id.org/biolink/vocab/DrugAvailabilityEnum#prescription> a owl:Class ;
    rdfs:label "prescription" .

biolink:DrugDeliveryEnum a owl:Class ;
    rdfs:label "DrugDeliveryEnum" ;
    owl:unionOf ( <https://w3id.org/biolink/vocab/DrugDeliveryEnum#inhalation> <https://w3id.org/biolink/vocab/DrugDeliveryEnum#oral> <https://w3id.org/biolink/vocab/DrugDeliveryEnum#absorption_through_the_skin> <https://w3id.org/biolink/vocab/DrugDeliveryEnum#intravenous_injection> ) ;
    linkml:permissible_values <https://w3id.org/biolink/vocab/DrugDeliveryEnum#absorption_through_the_skin>,
        <https://w3id.org/biolink/vocab/DrugDeliveryEnum#inhalation>,
        <https://w3id.org/biolink/vocab/DrugDeliveryEnum#intravenous_injection>,
        <https://w3id.org/biolink/vocab/DrugDeliveryEnum#oral> .

<https://w3id.org/biolink/vocab/DrugDeliveryEnum#absorption_through_the_skin> a owl:Class ;
    rdfs:label "absorption_through_the_skin" .

<https://w3id.org/biolink/vocab/DrugDeliveryEnum#inhalation> a owl:Class ;
    rdfs:label "inhalation" .

<https://w3id.org/biolink/vocab/DrugDeliveryEnum#intravenous_injection> a owl:Class ;
    rdfs:label "intravenous_injection" .

<https://w3id.org/biolink/vocab/DrugDeliveryEnum#oral> a owl:Class ;
    rdfs:label "oral" .

<https://w3id.org/biolink/vocab/DruggableGeneCategoryEnum#tbio> a owl:Class ;
    rdfs:label "tbio" .

<https://w3id.org/biolink/vocab/DruggableGeneCategoryEnum#tchem> a owl:Class ;
    rdfs:label "tchem" .

<https://w3id.org/biolink/vocab/DruggableGeneCategoryEnum#tclin> a owl:Class ;
    rdfs:label "tclin" .

<https://w3id.org/biolink/vocab/DruggableGeneCategoryEnum#tdark> a owl:Class ;
    rdfs:label "tdark" .

biolink:EntityToExposureEventAssociationMixin a owl:Class ;
    rdfs:label "entity to exposure event association mixin" ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:onClass biolink:ExposureEvent ;
            owl:onProperty rdf:object ;
            owl:qualifiedCardinality 1 ],
        linkml:mixin ;
    skos:definition "An association between some entity and an exposure event." .

biolink:EntityToFeatureOrDiseaseQualifiersMixin a owl:Class ;
    rdfs:label "entity to feature or disease qualifiers mixin" ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:maxQualifiedCardinality 1 ;
            owl:onClass biolink:SeverityValue ;
            owl:onProperty biolink:severity_qualifier ],
        [ a owl:Restriction ;
            owl:maxQualifiedCardinality 1 ;
            owl:onClass biolink:Onset ;
            owl:onProperty biolink:onset_qualifier ],
        biolink:FrequencyQualifierMixin,
        linkml:mixin ;
    skos:definition "Qualifiers for entity to disease or phenotype associations." .

biolink:EntityToOutcomeAssociationMixin a owl:Class ;
    rdfs:label "entity to outcome association mixin" ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:onClass biolink:Outcome ;
            owl:onProperty rdf:object ;
            owl:qualifiedCardinality 1 ],
        linkml:mixin ;
    skos:definition "An association between some entity and an outcome" .

biolink:EpigenomicEntity a owl:Class ;
    rdfs:label "epigenomic entity" ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:maxQualifiedCardinality 1 ;
            owl:onClass biolink:BiologicalSequence ;
            owl:onProperty biolink:has_biological_sequence ],
        linkml:mixin .

biolink:EvidenceType a owl:Class ;
    rdfs:label "evidence type" ;
    rdfs:subClassOf biolink:InformationContentEntity ;
    skos:altLabel "evidence code" ;
    skos:definition "Class of evidence that supports an association" ;
    skos:exactMatch <http://purl.obolibrary.org/obo/ECO_0000000> .

<https://w3id.org/biolink/vocab/FDAApprovalStatusEnum#discovery_and_development_phase> a owl:Class ;
    rdfs:label "discovery_and_development_phase" .

<https://w3id.org/biolink/vocab/FDAApprovalStatusEnum#fda_accelerated_approval> a owl:Class ;
    rdfs:label "fda_accelerated_approval" .

<https://w3id.org/biolink/vocab/FDAApprovalStatusEnum#fda_breakthrough_therapy> a owl:Class ;
    rdfs:label "fda_breakthrough_therapy" .

<https://w3id.org/biolink/vocab/FDAApprovalStatusEnum#fda_clinical_research_phase> a owl:Class ;
    rdfs:label "fda_clinical_research_phase" .

<https://w3id.org/biolink/vocab/FDAApprovalStatusEnum#fda_clinical_research_phase_1> a owl:Class ;
    rdfs:label "fda_clinical_research_phase_1" .

<https://w3id.org/biolink/vocab/FDAApprovalStatusEnum#fda_clinical_research_phase_2> a owl:Class ;
    rdfs:label "fda_clinical_research_phase_2" .

<https://w3id.org/biolink/vocab/FDAApprovalStatusEnum#fda_clinical_research_phase_3> a owl:Class ;
    rdfs:label "fda_clinical_research_phase_3" .

<https://w3id.org/biolink/vocab/FDAApprovalStatusEnum#fda_clinical_research_phase_4> a owl:Class ;
    rdfs:label "fda_clinical_research_phase_4" .

<https://w3id.org/biolink/vocab/FDAApprovalStatusEnum#fda_fast_track> a owl:Class ;
    rdfs:label "fda_fast_track" .

<https://w3id.org/biolink/vocab/FDAApprovalStatusEnum#fda_post_market_safety_review> a owl:Class ;
    rdfs:label "fda_post_market_safety_review" .

<https://w3id.org/biolink/vocab/FDAApprovalStatusEnum#fda_priority_review> a owl:Class ;
    rdfs:label "fda_priority_review" .

<https://w3id.org/biolink/vocab/FDAApprovalStatusEnum#fda_review_phase_4> a owl:Class ;
    rdfs:label "fda_review_phase_4" .

<https://w3id.org/biolink/vocab/FDAApprovalStatusEnum#post_approval_withdrawal> a owl:Class ;
    rdfs:label "post_approval_withdrawal" .

<https://w3id.org/biolink/vocab/FDAApprovalStatusEnum#preclinical_research_phase> a owl:Class ;
    rdfs:label "preclinical_research_phase" .

<https://w3id.org/biolink/vocab/FDAApprovalStatusEnum#regular_fda_approval> a owl:Class ;
    rdfs:label "regular_fda_approval" .

biolink:FDAIDAAdverseEventEnum a owl:Class ;
    rdfs:label "FDAIDAAdverseEventEnum" ;
    owl:unionOf ( <https://w3id.org/biolink/vocab/FDAIDAAdverseEventEnum#life_threatening_adverse_event> <https://w3id.org/biolink/vocab/FDAIDAAdverseEventEnum#serious_adverse_event> <https://w3id.org/biolink/vocab/FDAIDAAdverseEventEnum#suspected_adverse_reaction> <https://w3id.org/biolink/vocab/FDAIDAAdverseEventEnum#unexpected_adverse_event> ) ;
    linkml:permissible_values <https://w3id.org/biolink/vocab/FDAIDAAdverseEventEnum#life_threatening_adverse_event>,
        <https://w3id.org/biolink/vocab/FDAIDAAdverseEventEnum#serious_adverse_event>,
        <https://w3id.org/biolink/vocab/FDAIDAAdverseEventEnum#suspected_adverse_reaction>,
        <https://w3id.org/biolink/vocab/FDAIDAAdverseEventEnum#unexpected_adverse_event> .

<https://w3id.org/biolink/vocab/FDAIDAAdverseEventEnum#life_threatening_adverse_event> a owl:Class ;
    rdfs:label "life_threatening_adverse_event" .

<https://w3id.org/biolink/vocab/FDAIDAAdverseEventEnum#serious_adverse_event> a owl:Class ;
    rdfs:label "serious_adverse_event" .

<https://w3id.org/biolink/vocab/FDAIDAAdverseEventEnum#suspected_adverse_reaction> a owl:Class ;
    rdfs:label "suspected_adverse_reaction" .

<https://w3id.org/biolink/vocab/FDAIDAAdverseEventEnum#unexpected_adverse_event> a owl:Class ;
    rdfs:label "unexpected_adverse_event" .

biolink:FDA_approval_status a owl:ObjectProperty ;
    rdfs:label "FDA approval status" ;
    rdfs:domain biolink:Association ;
    rdfs:range biolink:FDAApprovalStatusEnum ;
    rdfs:subPropertyOf biolink:association_slot ;
    skos:definition "" .

biolink:FrequencyQuantifier a owl:Class ;
    rdfs:label "frequency quantifier" ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:maxQualifiedCardinality 1 ;
            owl:onClass linkml:Double ;
            owl:onProperty biolink:has_percentage ],
        [ a owl:Restriction ;
            owl:maxQualifiedCardinality 1 ;
            owl:onClass linkml:Double ;
            owl:onProperty biolink:has_quotient ],
        [ a owl:Restriction ;
            owl:maxQualifiedCardinality 1 ;
            owl:onClass linkml:Integer ;
            owl:onProperty biolink:has_total ],
        [ a owl:Restriction ;
            owl:maxQualifiedCardinality 1 ;
            owl:onClass linkml:Integer ;
            owl:onProperty biolink:has_count ],
        biolink:RelationshipQuantifier,
        linkml:mixin .

<https://w3id.org/biolink/vocab/GeneOrGeneProductOrChemicalEntityAspectEnum#ADP-ribosylation> a owl:Class ;
    rdfs:label "ADP-ribosylation" .

<https://w3id.org/biolink/vocab/GeneOrGeneProductOrChemicalEntityAspectEnum#abundance> a owl:Class ;
    rdfs:label "abundance" .

<https://w3id.org/biolink/vocab/GeneOrGeneProductOrChemicalEntityAspectEnum#acetylation> a owl:Class ;
    rdfs:label "acetylation" .

<https://w3id.org/biolink/vocab/GeneOrGeneProductOrChemicalEntityAspectEnum#activity> a owl:Class ;
    rdfs:label "activity" .

<https://w3id.org/biolink/vocab/GeneOrGeneProductOrChemicalEntityAspectEnum#activity_or_abundance> a owl:Class ;
    rdfs:label "activity_or_abundance" .

<https://w3id.org/biolink/vocab/GeneOrGeneProductOrChemicalEntityAspectEnum#acylation> a owl:Class ;
    rdfs:label "acylation" .

<https://w3id.org/biolink/vocab/GeneOrGeneProductOrChemicalEntityAspectEnum#alkylation> a owl:Class ;
    rdfs:label "alkylation" .

<https://w3id.org/biolink/vocab/GeneOrGeneProductOrChemicalEntityAspectEnum#amination> a owl:Class ;
    rdfs:label "amination" .

<https://w3id.org/biolink/vocab/GeneOrGeneProductOrChemicalEntityAspectEnum#carbamoylation> a owl:Class ;
    rdfs:label "carbamoylation" .

<https://w3id.org/biolink/vocab/GeneOrGeneProductOrChemicalEntityAspectEnum#carboxylation> a owl:Class ;
    rdfs:label "carboxylation" .

<https://w3id.org/biolink/vocab/GeneOrGeneProductOrChemicalEntityAspectEnum#cleavage> a owl:Class ;
    rdfs:label "cleavage" .

<https://w3id.org/biolink/vocab/GeneOrGeneProductOrChemicalEntityAspectEnum#degradation> a owl:Class ;
    rdfs:label "degradation" .

<https://w3id.org/biolink/vocab/GeneOrGeneProductOrChemicalEntityAspectEnum#ethylation> a owl:Class ;
    rdfs:label "ethylation" .

<https://w3id.org/biolink/vocab/GeneOrGeneProductOrChemicalEntityAspectEnum#expression> a owl:Class ;
    rdfs:label "expression" .

<https://w3id.org/biolink/vocab/GeneOrGeneProductOrChemicalEntityAspectEnum#farnesylation> a owl:Class ;
    rdfs:label "farnesylation" .

<https://w3id.org/biolink/vocab/GeneOrGeneProductOrChemicalEntityAspectEnum#folding> a owl:Class ;
    rdfs:label "folding" .

<https://w3id.org/biolink/vocab/GeneOrGeneProductOrChemicalEntityAspectEnum#geranoylation> a owl:Class ;
    rdfs:label "geranoylation" .

<https://w3id.org/biolink/vocab/GeneOrGeneProductOrChemicalEntityAspectEnum#glucuronidation> a owl:Class ;
    rdfs:label "glucuronidation" .

<https://w3id.org/biolink/vocab/GeneOrGeneProductOrChemicalEntityAspectEnum#glutathionylation> a owl:Class ;
    rdfs:label "glutathionylation" .

<https://w3id.org/biolink/vocab/GeneOrGeneProductOrChemicalEntityAspectEnum#glycation> a owl:Class ;
    rdfs:label "glycation" .

<https://w3id.org/biolink/vocab/GeneOrGeneProductOrChemicalEntityAspectEnum#glycosylation> a owl:Class ;
    rdfs:label "glycosylation" .

<https://w3id.org/biolink/vocab/GeneOrGeneProductOrChemicalEntityAspectEnum#hydrolysis> a owl:Class ;
    rdfs:label "hydrolysis" .

<https://w3id.org/biolink/vocab/GeneOrGeneProductOrChemicalEntityAspectEnum#hydroxylation> a owl:Class ;
    rdfs:label "hydroxylation" .

<https://w3id.org/biolink/vocab/GeneOrGeneProductOrChemicalEntityAspectEnum#lipidation> a owl:Class ;
    rdfs:label "lipidation" .

<https://w3id.org/biolink/vocab/GeneOrGeneProductOrChemicalEntityAspectEnum#localization> a owl:Class ;
    rdfs:label "localization" .

<https://w3id.org/biolink/vocab/GeneOrGeneProductOrChemicalEntityAspectEnum#metabolic_processing> a owl:Class ;
    rdfs:label "metabolic_processing" .

<https://w3id.org/biolink/vocab/GeneOrGeneProductOrChemicalEntityAspectEnum#methylation> a owl:Class ;
    rdfs:label "methylation" .

<https://w3id.org/biolink/vocab/GeneOrGeneProductOrChemicalEntityAspectEnum#molecular_modification> a owl:Class ;
    rdfs:label "molecular_modification" .

<https://w3id.org/biolink/vocab/GeneOrGeneProductOrChemicalEntityAspectEnum#mutation_rate> a owl:Class ;
    rdfs:label "mutation_rate" .

<https://w3id.org/biolink/vocab/GeneOrGeneProductOrChemicalEntityAspectEnum#myristoylation> a owl:Class ;
    rdfs:label "myristoylation" .

<https://w3id.org/biolink/vocab/GeneOrGeneProductOrChemicalEntityAspectEnum#n_linked_glycosylation> a owl:Class ;
    rdfs:label "n_linked_glycosylation" .

<https://w3id.org/biolink/vocab/GeneOrGeneProductOrChemicalEntityAspectEnum#nitrosation> a owl:Class ;
    rdfs:label "nitrosation" .

<https://w3id.org/biolink/vocab/GeneOrGeneProductOrChemicalEntityAspectEnum#nucleotidylation> a owl:Class ;
    rdfs:label "nucleotidylation" .

<https://w3id.org/biolink/vocab/GeneOrGeneProductOrChemicalEntityAspectEnum#o_linked_glycosylation> a owl:Class ;
    rdfs:label "o_linked_glycosylation" .

<https://w3id.org/biolink/vocab/GeneOrGeneProductOrChemicalEntityAspectEnum#oxidation> a owl:Class ;
    rdfs:label "oxidation" .

<https://w3id.org/biolink/vocab/GeneOrGeneProductOrChemicalEntityAspectEnum#palmitoylation> a owl:Class ;
    rdfs:label "palmitoylation" .

<https://w3id.org/biolink/vocab/GeneOrGeneProductOrChemicalEntityAspectEnum#phosphorylation> a owl:Class ;
    rdfs:label "phosphorylation" .

<https://w3id.org/biolink/vocab/GeneOrGeneProductOrChemicalEntityAspectEnum#prenylation> a owl:Class ;
    rdfs:label "prenylation" .

<https://w3id.org/biolink/vocab/GeneOrGeneProductOrChemicalEntityAspectEnum#reduction> a owl:Class ;
    rdfs:label "reduction" .

<https://w3id.org/biolink/vocab/GeneOrGeneProductOrChemicalEntityAspectEnum#ribosylation> a owl:Class ;
    rdfs:label "ribosylation" .

<https://w3id.org/biolink/vocab/GeneOrGeneProductOrChemicalEntityAspectEnum#secretion> a owl:Class ;
    rdfs:label "secretion" .

<https://w3id.org/biolink/vocab/GeneOrGeneProductOrChemicalEntityAspectEnum#stability> a owl:Class ;
    rdfs:label "stability" .

<https://w3id.org/biolink/vocab/GeneOrGeneProductOrChemicalEntityAspectEnum#sulfation> a owl:Class ;
    rdfs:label "sulfation" .

<https://w3id.org/biolink/vocab/GeneOrGeneProductOrChemicalEntityAspectEnum#sumoylation> a owl:Class ;
    rdfs:label "sumoylation" .

<https://w3id.org/biolink/vocab/GeneOrGeneProductOrChemicalEntityAspectEnum#synthesis> a owl:Class ;
    rdfs:label "synthesis" .

<https://w3id.org/biolink/vocab/GeneOrGeneProductOrChemicalEntityAspectEnum#transport> a owl:Class ;
    rdfs:label "transport" .

<https://w3id.org/biolink/vocab/GeneOrGeneProductOrChemicalEntityAspectEnum#ubiquitination> a owl:Class ;
    rdfs:label "ubiquitination" .

<https://w3id.org/biolink/vocab/GeneOrGeneProductOrChemicalEntityAspectEnum#uptake> a owl:Class ;
    rdfs:label "uptake" .

<https://w3id.org/biolink/vocab/GeneOrGeneProductOrChemicalPartQualifierEnum#3_prime_utr> a owl:Class ;
    rdfs:label "3_prime_utr" .

<https://w3id.org/biolink/vocab/GeneOrGeneProductOrChemicalPartQualifierEnum#5_prime_utr> a owl:Class ;
    rdfs:label "5_prime_utr" .

<https://w3id.org/biolink/vocab/GeneOrGeneProductOrChemicalPartQualifierEnum#enhancer> a owl:Class ;
    rdfs:label "enhancer" .

<https://w3id.org/biolink/vocab/GeneOrGeneProductOrChemicalPartQualifierEnum#exon> a owl:Class ;
    rdfs:label "exon" .

<https://w3id.org/biolink/vocab/GeneOrGeneProductOrChemicalPartQualifierEnum#intron> a owl:Class ;
    rdfs:label "intron" .

<https://w3id.org/biolink/vocab/GeneOrGeneProductOrChemicalPartQualifierEnum#polya_tail> a owl:Class ;
    rdfs:label "polya_tail" .

<https://w3id.org/biolink/vocab/GeneOrGeneProductOrChemicalPartQualifierEnum#promoter> a owl:Class ;
    rdfs:label "promoter" .

biolink:IriType a owl:Class ;
    rdfs:label "iri type" ;
    rdfs:subClassOf linkml:Uriorcurie .

<https://w3id.org/biolink/vocab/LogicalInterpretationEnum#inverse_all_some> a owl:Class ;
    rdfs:label "inverse_all_some" .

biolink:MaterialSample a owl:Class ;
    rdfs:label "material sample" ;
    rdfs:subClassOf biolink:PhysicalEntity,
        biolink:SubjectOfInvestigation ;
    skos:altLabel "biosample",
        "biospecimen",
        "physical sample",
        "sample" ;
    skos:definition "A sample is a limited quantity of something (e.g. an individual or set of individuals from a population, or a portion of a substance) to be used for testing, analysis, inspection, investigation, demonstration, or trial use. [SIO]" ;
    skos:exactMatch <http://purl.obolibrary.org/obo/OBI_0000747>,
        SIO:001050 .

biolink:MaterialSampleToEntityAssociationMixin a owl:Class ;
    rdfs:label "material sample to entity association mixin" ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:onClass biolink:MaterialSample ;
            owl:onProperty rdf:subject ;
            owl:qualifiedCardinality 1 ],
        linkml:mixin ;
    skos:definition "An association between a material sample and something." .

biolink:NarrativeText a owl:Class ;
    rdfs:label "narrative text" ;
    rdfs:subClassOf linkml:String .

biolink:NoncodingRNAProduct a owl:Class ;
    rdfs:label "noncoding RNA product" ;
    rdfs:subClassOf biolink:RNAProduct ;
    skos:exactMatch <http://purl.obolibrary.org/obo/SO_0000655>,
        SIO:001235 .

biolink:OrganismTaxonToOrganismTaxonAssociation a owl:Class ;
    rdfs:label "organism taxon to organism taxon association" ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:onClass biolink:OrganismTaxon ;
            owl:onProperty rdf:subject ;
            owl:qualifiedCardinality 1 ],
        [ a owl:Restriction ;
            owl:onClass biolink:OrganismTaxon ;
            owl:onProperty rdf:object ;
            owl:qualifiedCardinality 1 ],
        biolink:Association,
        biolink:OrganismTaxonToEntityAssociation ;
    skos:definition "A relationship between two organism taxon nodes" .

biolink:PhaseEnum a owl:Class ;
    rdfs:label "PhaseEnum" ;
    owl:unionOf ( <https://w3id.org/biolink/vocab/PhaseEnum#0> <https://w3id.org/biolink/vocab/PhaseEnum#1> <https://w3id.org/biolink/vocab/PhaseEnum#2> ) ;
    linkml:permissible_values <https://w3id.org/biolink/vocab/PhaseEnum#0>,
        <https://w3id.org/biolink/vocab/PhaseEnum#1>,
        <https://w3id.org/biolink/vocab/PhaseEnum#2> .

<https://w3id.org/biolink/vocab/PhaseEnum#0> a owl:Class ;
    rdfs:label "0" .

<https://w3id.org/biolink/vocab/PhaseEnum#1> a owl:Class ;
    rdfs:label "1" .

<https://w3id.org/biolink/vocab/PhaseEnum#2> a owl:Class ;
    rdfs:label "2" .

biolink:Procedure a owl:Class ;
    rdfs:label "procedure" ;
    rdfs:subClassOf biolink:ActivityAndBehavior,
        biolink:NamedThing ;
    skos:definition "A series of actions conducted in a certain order or manner" ;
    skos:exactMatch dcid:MedicalProcedure,
        UMLSSG:PROC ;
    skos:narrowMatch STY:T059,
        STY:T060,
        STY:T061,
        STY:T063 .

biolink:RNAProduct a owl:Class ;
    rdfs:label "RNA product" ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:allValuesFrom biolink:LabelType ;
            owl:onProperty biolink:synonym ],
        biolink:GeneProductMixin,
        biolink:Transcript ;
    skos:exactMatch <http://purl.obolibrary.org/obo/CHEBI_33697>,
        WIKIDATA:Q11053 .

biolink:ReactionDirectionEnum a owl:Class ;
    rdfs:label "ReactionDirectionEnum" ;
    owl:unionOf ( <https://w3id.org/biolink/vocab/ReactionDirectionEnum#left_to_right> <https://w3id.org/biolink/vocab/ReactionDirectionEnum#right_to_left> <https://w3id.org/biolink/vocab/ReactionDirectionEnum#bidirectional> <https://w3id.org/biolink/vocab/ReactionDirectionEnum#neutral> ) ;
    linkml:permissible_values <https://w3id.org/biolink/vocab/ReactionDirectionEnum#bidirectional>,
        <https://w3id.org/biolink/vocab/ReactionDirectionEnum#left_to_right>,
        <https://w3id.org/biolink/vocab/ReactionDirectionEnum#neutral>,
        <https://w3id.org/biolink/vocab/ReactionDirectionEnum#right_to_left> .

<https://w3id.org/biolink/vocab/ReactionDirectionEnum#bidirectional> a owl:Class ;
    rdfs:label "bidirectional" .

<https://w3id.org/biolink/vocab/ReactionDirectionEnum#left_to_right> a owl:Class ;
    rdfs:label "left_to_right" .

<https://w3id.org/biolink/vocab/ReactionDirectionEnum#neutral> a owl:Class ;
    rdfs:label "neutral" .

<https://w3id.org/biolink/vocab/ReactionDirectionEnum#right_to_left> a owl:Class ;
    rdfs:label "right_to_left" .

biolink:ReactionSideEnum a owl:Class ;
    rdfs:label "ReactionSideEnum" ;
    owl:unionOf ( <https://w3id.org/biolink/vocab/ReactionSideEnum#left> <https://w3id.org/biolink/vocab/ReactionSideEnum#right> ) ;
    linkml:permissible_values <https://w3id.org/biolink/vocab/ReactionSideEnum#left>,
        <https://w3id.org/biolink/vocab/ReactionSideEnum#right> .

<https://w3id.org/biolink/vocab/ReactionSideEnum#left> a owl:Class ;
    rdfs:label "left" .

<https://w3id.org/biolink/vocab/ReactionSideEnum#right> a owl:Class ;
    rdfs:label "right" .

<https://w3id.org/biolink/vocab/SequenceEnum#aa> a owl:Class ;
    rdfs:label "aa" .

<https://w3id.org/biolink/vocab/SequenceEnum#na> a owl:Class ;
    rdfs:label "na" .

biolink:SocioeconomicAttribute a owl:Class ;
    rdfs:label "socioeconomic attribute" ;
    rdfs:subClassOf biolink:Attribute ;
    skos:definition "Attributes relating to a socioeconomic manifestation" .

<https://w3id.org/biolink/vocab/StrandEnum#+> a owl:Class ;
    rdfs:label "+" .

<https://w3id.org/biolink/vocab/StrandEnum#-> a owl:Class ;
    rdfs:label "-" .

<https://w3id.org/biolink/vocab/StrandEnum#.> a owl:Class ;
    rdfs:label "." .

<https://w3id.org/biolink/vocab/StrandEnum#?> a owl:Class ;
    rdfs:label "?" .

biolink:TaxonomicRank a owl:Class ;
    rdfs:label "taxonomic rank" ;
    rdfs:subClassOf biolink:OntologyClass ;
    skos:definition "A descriptor for the rank within a taxonomic classification. Example instance: TAXRANK:0000017 (kingdom)" ;
    skos:exactMatch WIKIDATA:Q427626 .

biolink:Unit a owl:Class ;
    rdfs:label "unit" ;
    rdfs:subClassOf linkml:String .

biolink:Zygosity a owl:Class ;
    rdfs:label "zygosity" ;
    rdfs:subClassOf biolink:Attribute ;
    skos:exactMatch <http://purl.obolibrary.org/obo/GENO_0000133> .

biolink:actively_involved_in a owl:ObjectProperty ;
    rdfs:label "actively involved in" ;
    rdfs:domain biolink:Occurrent ;
    rdfs:range biolink:MolecularActivity ;
    rdfs:subPropertyOf biolink:participates_in ;
    owl:inverseOf biolink:actively_involves ;
    skos:altLabel "involved in" ;
    skos:definition "holds between a continuant and a process or function, where the continuant actively contributes to part or all of the process or function it realizes" ;
    skos:exactMatch RO:0002331,
        RO:0002432 ;
    skos:narrowMatch RO:0002503,
        NBO-PROPERTY:by_means,
        orphanet:317348,
        orphanet:317349,
        orphanet:327767 ;
    biolink:canonical_predicate "True" .

biolink:actively_involves a owl:ObjectProperty ;
    rdfs:label "actively involves" ;
    rdfs:domain biolink:MolecularActivity ;
    rdfs:range biolink:Occurrent ;
    rdfs:subPropertyOf biolink:has_participant ;
    owl:inverseOf biolink:actively_involved_in ;
    skos:exactMatch RO:0002331 .

biolink:ameliorates a owl:ObjectProperty ;
    rdfs:label "ameliorates" ;
    rdfs:domain biolink:NamedThing ;
    rdfs:range biolink:DiseaseOrPhenotypicFeature ;
    rdfs:subPropertyOf biolink:affects ;
    owl:inverseOf biolink:is_ameliorated_by ;
    skos:definition "A relationship between an entity (e.g. a genotype, genetic variation, chemical, or environmental exposure, clinical intervention) and a condition (a phenotype or disease), where the presence of the entity reduces or eliminates some or all aspects of the condition." ;
    skos:exactMatch RO:0003307 ;
    biolink:canonical_predicate "True" ;
    biolink:opposite_of "exacerbates" .

biolink:aspect_qualifier a owl:ObjectProperty ;
    rdfs:label "aspect qualifier" ;
    rdfs:domain biolink:Association ;
    rdfs:range linkml:String ;
    rdfs:subPropertyOf biolink:qualifier ;
    skos:definition "Composes with the core concept to describe new concepts of a different ontological type. e.g. a process in which the core concept participates, a function/activity/role held by the core concept, or a characteristic/quality that inheres in the core concept.  The purpose of the aspect slot is to indicate what aspect is being affected in an  'affects' association." ;
    skos:editorialNote "for good examples of aspects in the gene-> chemical space, please see the  GeneOrGeneProductOrChemicalEntityAspectEnum (below) which lists many aspects that can be used to qualify  the gene making the full subject a different ontological type.   the qualifier ‘expression’ combines with a core concept of ‘Gene X’ to express the composed concept ‘expression of Gene X’ (Gene → Biological Process) the qualifier ‘exposure’ combines with a core concept of ‘Chemical X’ to express the composed concept ‘exposure to Chemical X’ (Chemical → Exposure Process) the qualifier ‘activity’ combines with a core concept of ‘PPARG’ to express the concept ‘activity of PPARG’ (Gene → function/activity) the qualifier ‘emergency Department Visit’ combines with a core concept of ‘Disease X’ to express the concept ‘Emergency Department visits for Disease X’ (Disease → Clinical Event) the qualifier ‘infection’ combines with a core concept of ‘Giardia’ to express the concept ‘Infection with Giardia’ (Taxon → Biological / Pathological Process) the qualifier ‘severity’ combines with a core concept of ‘DILI’ to express the concept ‘the severity level of DILI’ (Disease → (intrinsic) Characteristic/Quality) the qualifier ‘abundance’ combines with a core concept of ‘BRCA2’ to express the concept ‘abundance of BRCA2’ (Gene → (extrinsic) characteristic/quality)" ;
    linkml:examples "Example(value='abundance', description=None)",
        "Example(value='exposure', description=None)",
        "Example(value='expression', description=None)",
        "Example(value='stability', description=None)" .

biolink:base_coordinate a owl:ObjectProperty ;
    rdfs:label "base coordinate" ;
    rdfs:domain biolink:GenomicSequenceLocalization ;
    rdfs:range linkml:Integer ;
    rdfs:subPropertyOf biolink:sequence_localization_attribute ;
    skos:altLabel "fully-closed",
        "one-based" ;
    skos:definition "A position in the base coordinate system.  Base coordinates start at position 1 instead of position 0." .

biolink:broad_match a owl:ObjectProperty ;
    rdfs:label "broad match" ;
    rdfs:domain biolink:NamedThing ;
    rdfs:range biolink:NamedThing ;
    rdfs:subPropertyOf biolink:related_to_at_concept_level ;
    owl:inverseOf biolink:narrow_match ;
    skos:definition "a list of terms from different schemas or terminology systems that have a broader, more general meaning. Broader terms are typically shown as parents in a hierarchy or tree." ;
    skos:exactMatch skos:broadMatch,
        WIKIDATA:Q39894595 ;
    biolink:canonical_predicate "True" ;
    biolink:opposite_of "narrow match" .

biolink:causal_mechanism_qualifier a owl:ObjectProperty ;
    rdfs:label "causal mechanism qualifier" ;
    rdfs:domain biolink:Association ;
    rdfs:range biolink:CausalMechanismQualifierEnum ;
    rdfs:subPropertyOf biolink:statement_qualifier ;
    skos:definition "A statement qualifier representing a type of molecular control mechanism through which an effect of a chemical on a gene or gene product is mediated (e.g. 'agonism', 'inhibition', 'allosteric modulation', 'channel blocker')" .

biolink:context_qualifier a owl:ObjectProperty ;
    rdfs:label "context qualifier" ;
    rdfs:domain biolink:Association ;
    rdfs:range linkml:String ;
    rdfs:subPropertyOf biolink:qualifier ;
    skos:definition "Restricts the setting/context/location where the core concept (or qualified core concept) resides or occurs." ;
    linkml:examples "Example(value='cohort x (e.g. a specific population, referenced by an identifier)', description=None)",
        "Example(value='gut microbiome', description=None)" .

biolink:contributes_to a owl:ObjectProperty ;
    rdfs:label "contributes to" ;
    rdfs:domain biolink:NamedThing ;
    rdfs:range biolink:NamedThing ;
    rdfs:subPropertyOf biolink:related_to_at_instance_level ;
    owl:inverseOf biolink:contribution_from ;
    skos:closeMatch <http://purl.obolibrary.org/obo/IDO_0000664> ;
    skos:definition "holds between two entities where the occurrence, existence, or activity of one causes or contributes to the occurrence or generation of the other" ;
    skos:exactMatch RO:0002326 ;
    skos:narrowMatch CTD:marker_mechanism,
        <http://purl.obolibrary.org/obo/MONDO_predisposes_towards>,
        RO:0002255,
        RO:0003304 ;
    biolink:canonical_predicate "True" .

biolink:contribution_from a owl:ObjectProperty ;
    rdfs:label "contribution from" ;
    rdfs:domain biolink:NamedThing ;
    rdfs:range biolink:NamedThing ;
    rdfs:subPropertyOf biolink:related_to_at_instance_level ;
    owl:inverseOf biolink:contributes_to .

biolink:derivative_qualifier a owl:ObjectProperty ;
    rdfs:label "derivative qualifier" ;
    rdfs:domain biolink:Association ;
    rdfs:range linkml:String ;
    rdfs:subPropertyOf biolink:qualifier ;
    skos:definition "A qualifier that composes with a core subject/object  concept to describe something that is derived from the core concept.  For example, the qualifier ‘metabolite’ combines with a ‘Chemical X’ core concept to express the composed concept ‘a metabolite of Chemical X’." ;
    linkml:examples "Example(value='metabolite', description=None)" .

biolink:derives_from a owl:ObjectProperty ;
    rdfs:label "derives from" ;
    rdfs:domain biolink:NamedThing ;
    rdfs:range biolink:NamedThing ;
    rdfs:subPropertyOf biolink:related_to_at_instance_level ;
    owl:inverseOf biolink:derives_into ;
    skos:definition "holds between two distinct material entities, the new entity and the old entity, in which the new entity begins to exist when the old entity ceases to exist, and the new entity inherits the significant portion of the matter of the old entity" ;
    skos:exactMatch <http://purl.obolibrary.org/obo/FMA_derives_from>,
        RO:0001000,
        DOID-PROPERTY:derives_from ;
    skos:narrowMatch <http://purl.obolibrary.org/obo/CHEBI_has_functional_parent>,
        <http://purl.obolibrary.org/obo/SNOMED_has_specimen_source_topography> ;
    biolink:canonical_predicate "True" .

biolink:derives_into a owl:ObjectProperty ;
    rdfs:label "derives into" ;
    rdfs:domain biolink:NamedThing ;
    rdfs:range biolink:NamedThing ;
    rdfs:subPropertyOf biolink:related_to_at_instance_level ;
    owl:inverseOf biolink:derives_from ;
    skos:altLabel "is normal cell origin of disease",
        "may be normal cell origin of disease" ;
    skos:definition "holds between two distinct material entities, the old entity and the new entity, in which the new entity begins to exist when the old entity ceases to exist, and the new entity inherits the significant portion of the matter of the old entity" ;
    skos:exactMatch <http://purl.obolibrary.org/obo/FMA_derives>,
        RO:0001001,
        SEMMEDDB:CONVERTS_TO .

biolink:direction_qualifier a owl:ObjectProperty ;
    rdfs:label "direction qualifier" ;
    rdfs:domain biolink:Association ;
    rdfs:range linkml:String ;
    rdfs:subPropertyOf biolink:qualifier ;
    skos:definition "Composes with the core concept (+ aspect if provided) to describe a change in its direction or degree." ;
    skos:editorialNote "the qualifier ‘increased’ combines with a core concept of ‘Gene X’ and an aspect of ‘expression’ to express the composed concept ‘increased expression of Gene X’    the qualifier ‘decreased’ combines with a core concept of ‘Protein X’ and an aspect of ‘abundance’ to express the composed concept ‘decreased abundance of Protein X’" .

biolink:exact_match a owl:ObjectProperty,
        owl:SymmetricProperty ;
    rdfs:label "exact match" ;
    rdfs:domain biolink:NamedThing ;
    rdfs:range biolink:NamedThing ;
    rdfs:subPropertyOf biolink:close_match ;
    skos:definition "holds between two entities that have strictly equivalent meanings, with a high degree of confidence" ;
    skos:exactMatch skos:exactMatch,
        WIKIDATA:P2888,
        WIKIDATA:Q39893449 ;
    biolink:canonical_predicate "True" .

biolink:food_component_of a owl:ObjectProperty ;
    rdfs:label "food component of" ;
    rdfs:domain biolink:ChemicalEntity ;
    rdfs:range biolink:ChemicalEntity ;
    rdfs:subPropertyOf biolink:part_of ;
    owl:inverseOf biolink:has_food_component ;
    skos:definition "holds between a one or more chemical entities present in food, irrespective of nutritional value (i.e. could also be a contaminant or additive)" .

biolink:form_or_variant_qualifier a owl:ObjectProperty ;
    rdfs:label "form or variant qualifier" ;
    rdfs:domain biolink:Association ;
    rdfs:range linkml:String ;
    rdfs:subPropertyOf biolink:qualifier ;
    skos:definition "A qualifier that composes with a core subject/object concept to define a specific type, variant, alternative version of this concept. The composed concept remains a subtype or instance of the core concept. For example, the qualifier ‘mutation’ combines with the core concept ‘Gene X’ to express the compose concept ‘a mutation of Gene X’." ;
    skos:editorialNote "please see the ChemicalOrGeneOrGeneProductFormOrVariantEnum (below) for examples of 'form or variant qualifier' terms in the gene->chemical association space.  the qualifier ‘mutation’ combines with the core concept ‘Gene X’ to express the compose concept ‘Mutated forms of Gene X’. the qualifier ‘late stage’ combines with a core concept of ‘Disease X’ to express the  more specific concept ‘Late Stage forms of Disease X’ the qualifier ‘recombinant’ combines with a core concept of ‘FLT1 Gene’ to express the composed concept ‘Recombinant forms of the FLT1 gene’ the qualifier ‘chemical analog’ combines with a core concept of ‘Ditiocarb’ to express the composed concept ‘analog forms of Ditiocarb’" ;
    linkml:examples "Example(value='chemical analog', description=None)",
        "Example(value='late stage', description=None)",
        "Example(value='mutation', description=None)",
        "Example(value='severe', description=None)",
        "Example(value='transplant', description=None)" .

biolink:genetic_association a owl:ObjectProperty,
        owl:SymmetricProperty ;
    rdfs:label "genetic association" ;
    rdfs:domain biolink:NamedThing ;
    rdfs:range biolink:NamedThing ;
    rdfs:subPropertyOf biolink:related_to_at_instance_level ;
    skos:definition "Co-occurrence of a certain allele of a genetic marker and the phenotype of interest in the same individuals at above-chance level" ;
    skos:exactMatch WIKIDATA_PROPERTY:P2293 ;
    biolink:canonical_predicate "True" .

biolink:has_attribute_type a owl:ObjectProperty ;
    rdfs:label "has attribute type" ;
    rdfs:domain biolink:Attribute ;
    rdfs:range biolink:OntologyClass ;
    skos:definition "connects an attribute to a class that describes it" ;
    skos:narrowMatch LOINC:has_modality_type,
        LOINC:has_view_type .

biolink:has_evidence a owl:ObjectProperty ;
    rdfs:label "has evidence" ;
    rdfs:domain biolink:Association ;
    rdfs:range biolink:EvidenceType ;
    rdfs:subPropertyOf biolink:association_slot ;
    skos:definition "connects an association to an instance of supporting evidence" ;
    skos:exactMatch RO:0002558 .

biolink:has_food_component a owl:ObjectProperty ;
    rdfs:label "has food component" ;
    rdfs:domain biolink:ChemicalEntity ;
    rdfs:range biolink:ChemicalEntity ;
    rdfs:subPropertyOf biolink:has_part ;
    owl:inverseOf biolink:food_component_of ;
    skos:definition "holds between food and one or more chemical entities composing it, irrespective of nutritional value (i.e. could also be a contaminant or additive)" ;
    biolink:canonical_predicate "True" .

biolink:has_manifestation a owl:ObjectProperty ;
    rdfs:label "has manifestation" ;
    rdfs:domain biolink:Disease ;
    rdfs:range biolink:NamedThing ;
    rdfs:subPropertyOf biolink:related_to_at_instance_level ;
    owl:inverseOf biolink:manifestation_of .

biolink:interbase_coordinate a owl:ObjectProperty ;
    rdfs:label "interbase coordinate" ;
    rdfs:domain biolink:GenomicSequenceLocalization ;
    rdfs:range linkml:Integer ;
    rdfs:subPropertyOf biolink:sequence_localization_attribute ;
    skos:altLabel "half-open",
        "space-based",
        "zero-based" ;
    skos:definition "A position in interbase coordinates. Interbase coordinates start at position 0 instead of position 1. This is applied to a sequence localization edge." .

biolink:is_ameliorated_by a owl:ObjectProperty ;
    rdfs:label "is ameliorated by" ;
    rdfs:domain biolink:DiseaseOrPhenotypicFeature ;
    rdfs:range biolink:NamedThing ;
    rdfs:subPropertyOf biolink:affected_by ;
    owl:inverseOf biolink:ameliorates .

biolink:is_input_of a owl:ObjectProperty ;
    rdfs:label "is input of" ;
    rdfs:domain biolink:Occurrent ;
    rdfs:range biolink:BiologicalProcessOrActivity ;
    rdfs:subPropertyOf biolink:participates_in ;
    owl:inverseOf biolink:has_input .

biolink:iso_abbreviation a owl:ObjectProperty ;
    rdfs:label "iso abbreviation" ;
    rdfs:domain biolink:Publication ;
    rdfs:range linkml:String ;
    rdfs:subPropertyOf biolink:node_property ;
    skos:definition "Standard abbreviation for periodicals in the International Organization for Standardization (ISO) 4 system See https://www.issn.org/services/online-services/access-to-the-ltwa/. If the 'published in' property is set, then the iso abbreviation pertains to the broader publication context (the journal) within which the given publication node is embedded, not the publication itself." ;
    skos:exactMatch WIKIDATA_PROPERTY:P1160 .

biolink:issue a owl:ObjectProperty ;
    rdfs:label "issue" ;
    rdfs:domain biolink:Publication ;
    rdfs:range linkml:String ;
    rdfs:subPropertyOf biolink:node_property ;
    skos:definition "issue of a newspaper, a scientific journal or magazine for reference purpose" ;
    skos:exactMatch WIKIDATA_PROPERTY:P433 .

biolink:located_in a owl:ObjectProperty ;
    rdfs:label "located in" ;
    rdfs:domain biolink:NamedThing ;
    rdfs:range biolink:NamedThing ;
    rdfs:subPropertyOf biolink:related_to_at_instance_level ;
    owl:inverseOf biolink:location_of ;
    skos:definition "holds between a material entity and a material entity or site within which it is located (but of which it is not considered a part)" ;
    skos:exactMatch <http://purl.obolibrary.org/obo/FMA_has_location>,
        RO:0001025 ;
    skos:narrowMatch <http://identifiers.org/hmdb/at_cellular_location>,
        <http://identifiers.org/hmdb/at_tissue>,
        <http://identifiers.org/hmdb/in_biospecimen>,
        LOINC:has_imaging_focus,
        <http://purl.obolibrary.org/obo/BSPO_0000107>,
        <http://purl.obolibrary.org/obo/BSPO_0000108>,
        <http://purl.obolibrary.org/obo/BSPO_0000120>,
        <http://purl.obolibrary.org/obo/BSPO_0000121>,
        <http://purl.obolibrary.org/obo/BSPO_0000122>,
        <http://purl.obolibrary.org/obo/BSPO_0000123>,
        <http://purl.obolibrary.org/obo/BSPO_0000124>,
        <http://purl.obolibrary.org/obo/BSPO_0000125>,
        <http://purl.obolibrary.org/obo/BSPO_0000126>,
        <http://purl.obolibrary.org/obo/BSPO_0001100>,
        <http://purl.obolibrary.org/obo/BSPO_0001101>,
        <http://purl.obolibrary.org/obo/BSPO_0001107>,
        <http://purl.obolibrary.org/obo/BSPO_0015101>,
        <http://purl.obolibrary.org/obo/BSPO_0015102>,
        <http://purl.obolibrary.org/obo/BSPO_0015202>,
        <http://purl.obolibrary.org/obo/FMA_has_location>,
        GOREL:0001004,
        <http://purl.obolibrary.org/obo/NCIT_R100>,
        <http://purl.obolibrary.org/obo/NCIT_R145>,
        <http://purl.obolibrary.org/obo/NCIT_R155>,
        <http://purl.obolibrary.org/obo/NCIT_R156>,
        <http://purl.obolibrary.org/obo/NCIT_R165>,
        <http://purl.obolibrary.org/obo/NCIT_R166>,
        <http://purl.obolibrary.org/obo/NCIT_R167>,
        <http://purl.obolibrary.org/obo/NCIT_R168>,
        <http://purl.obolibrary.org/obo/NCIT_R169>,
        <http://purl.obolibrary.org/obo/NCIT_R170>,
        <http://purl.obolibrary.org/obo/NCIT_R171>,
        <http://purl.obolibrary.org/obo/NCIT_R40>,
        RO:0002303,
        <http://purl.obolibrary.org/obo/SNOMED_has_finding_site>,
        <http://purl.obolibrary.org/obo/SNOMED_has_indirect_procedure_site>,
        <http://purl.obolibrary.org/obo/SNOMED_has_inherent_location>,
        UBERON_CORE:in_central_side_of,
        UBERON_CORE:in_innermost_side_of,
        UBERON_CORE:in_outermost_side_of,
        EFO:0000784 ;
    biolink:canonical_predicate "True" .

biolink:location_of a owl:ObjectProperty ;
    rdfs:label "location of" ;
    rdfs:domain biolink:NamedThing ;
    rdfs:range biolink:NamedThing ;
    rdfs:subPropertyOf biolink:related_to_at_instance_level ;
    owl:inverseOf biolink:located_in ;
    skos:altLabel "site of" ;
    skos:definition "holds between material entity or site and a material entity that is located within it (but not considered a part of it)" ;
    skos:exactMatch <http://purl.obolibrary.org/obo/FMA_location_of>,
        RO:0001015,
        SEMMEDDB:LOCATION_OF,
        WIKIDATA_PROPERTY:P276 ;
    skos:narrowMatch <http://purl.obolibrary.org/obo/NCIT_Anatomic_Structure_Has_Location_Role>,
        <http://purl.obolibrary.org/obo/SNOMED_inherent_location_of> .

biolink:manifestation_of a owl:ObjectProperty ;
    rdfs:label "manifestation of" ;
    rdfs:domain biolink:NamedThing ;
    rdfs:range biolink:Disease ;
    rdfs:subPropertyOf biolink:related_to_at_instance_level ;
    owl:inverseOf biolink:has_manifestation ;
    skos:broadMatch WIKIDATA_PROPERTY:P1557 ;
    skos:definition "that part of a phenomenon which is directly observable or visibly expressed, or which gives evidence to the underlying process; used in SemMedDB for linking things like dysfunctions and processes to some disease or syndrome" ;
    skos:exactMatch <http://purl.obolibrary.org/obo/OMIM_manifestation_of>,
        SEMMEDDB:MANIFESTATION_OF ;
    skos:narrowMatch <http://purl.obolibrary.org/obo/SNOMED_has_definitional_manifestation> ;
    biolink:canonical_predicate "True" .

biolink:narrow_match a owl:ObjectProperty ;
    rdfs:label "narrow match" ;
    rdfs:domain biolink:NamedThing ;
    rdfs:range biolink:NamedThing ;
    rdfs:subPropertyOf biolink:related_to_at_concept_level ;
    owl:inverseOf biolink:broad_match ;
    skos:definition "a list of terms from different schemas or terminology systems that have a narrower, more specific meaning. Narrower terms are typically shown as children in a hierarchy or tree." ;
    skos:exactMatch skos:narrowMatch,
        WIKIDATA:Q39893967 ;
    biolink:opposite_of "broad match" .

biolink:overlaps a owl:ObjectProperty,
        owl:SymmetricProperty ;
    rdfs:label "overlaps" ;
    rdfs:domain biolink:NamedThing ;
    rdfs:range biolink:NamedThing ;
    rdfs:subPropertyOf biolink:related_to_at_instance_level ;
    skos:definition "holds between entities that overlap in their extents (materials or processes)" ;
    skos:exactMatch RO:0002131 ;
    skos:narrowMatch <http://purl.obolibrary.org/obo/BSPO_0005001>,
        RO:0002100,
        RO:0002102,
        RO:0002433,
        CHEMBL.MECHANISM:overlaps_with ;
    biolink:canonical_predicate "True" .

biolink:part_qualifier a owl:ObjectProperty ;
    rdfs:label "part qualifier" ;
    rdfs:domain biolink:Association ;
    rdfs:range linkml:String ;
    rdfs:subPropertyOf biolink:qualifier ;
    skos:definition "defines a specific part/component of the core concept (used in cases there this specific part has no IRI we can use to directly represent it, e.g. 'ESR1 transcript' q: polyA tail)." ;
    linkml:examples "Example(value='polyA tail', description=None)",
        "Example(value='upstream control region', description=None)" .

biolink:physically_interacts_with a owl:ObjectProperty,
        owl:SymmetricProperty ;
    rdfs:label "physically interacts with" ;
    rdfs:domain biolink:NamedThing ;
    rdfs:range biolink:NamedThing ;
    rdfs:subPropertyOf biolink:interacts_with ;
    skos:broadMatch WIKIDATA_PROPERTY:P129 ;
    skos:closeMatch <http://identifiers.org/drugbank/target>,
        CHEMBL.MECHANISM:binding_agent,
        CHEMBL.MECHANISM:chelating_agent,
        CHEMBL.MECHANISM:cross-linking_agent,
        CHEMBL.MECHANISM:oxidative_enzyme,
        CHEMBL.MECHANISM:sequestering_agent,
        CHEMBL.MECHANISM:substrate ;
    skos:definition "holds between two entities that make physical contact as part of some interaction.  does not imply a causal relationship." ;
    skos:narrowMatch <http://identifiers.org/drugbank/drug-interaction>,
        <http://purl.obolibrary.org/obo/FMA_adheres_to>,
        <http://purl.obolibrary.org/obo/NCIT_A7>,
        <http://purl.obolibrary.org/obo/PR_non-covalently_bound_to> ;
    biolink:canonical_predicate "True" .

biolink:published_in a owl:ObjectProperty ;
    rdfs:label "published in" ;
    rdfs:domain biolink:Publication ;
    rdfs:range linkml:Uriorcurie ;
    rdfs:subPropertyOf biolink:node_property ;
    skos:definition "CURIE identifier of a broader publication context within which the publication may be placed, e.g. a specified book or journal." ;
    skos:exactMatch WIKIDATA_PROPERTY:P1433 .

biolink:qualified_predicate a owl:ObjectProperty ;
    rdfs:label "qualified predicate" ;
    rdfs:domain biolink:Association ;
    rdfs:range linkml:String ;
    rdfs:subPropertyOf biolink:qualifier ;
    skos:definition "Predicate to be used in an association when subject and object qualifiers are present and the full reading of the statement requires a qualification to the predicate in use in order to refine or  increase the specificity of the full statement reading.  This qualifier holds a relationship to be used instead of that  expressed by the primary predicate, in a ‘full statement’ reading of the association, where qualifier-based  semantics are included.  This is necessary only in cases where the primary predicate does not work in a  full statement reading." ;
    skos:editorialNote "to express the statement that “Chemical X causes increased expression of Gene Y”, the core triple is read  using the fields subject:ChemX, predicate:affects, object:GeneY . . . and the full statement is read using  the fields subject:ChemX, qualified_predicate:causes, object:GeneY, object_aspect: expression,  object_direction:increased. The predicate ‘affects’ is needed for the core triple reading, but doesnt make  sense in the full statement reading  (because “Chemical X affects increased expression of Gene Y'' is not  what we mean to say here: it causes increased expression of Gene Y)" .

biolink:qualifiers a owl:ObjectProperty ;
    rdfs:label "qualifiers" ;
    rdfs:domain biolink:Association ;
    rdfs:range biolink:OntologyClass ;
    rdfs:subPropertyOf biolink:association_slot ;
    skos:definition "connects an association to qualifiers that modify or qualify the meaning of that association" .

biolink:similar_to a owl:ObjectProperty,
        owl:SymmetricProperty ;
    rdfs:label "similar to" ;
    rdfs:domain biolink:NamedThing ;
    rdfs:range biolink:NamedThing ;
    rdfs:subPropertyOf biolink:related_to_at_instance_level ;
    skos:definition "holds between an entity and some other entity with similar features." ;
    skos:exactMatch RO:HOM0000000,
        <http://purl.obolibrary.org/obo/SO_similar_to> ;
    biolink:canonical_predicate "True" .

biolink:species_context_qualifier a owl:ObjectProperty ;
    rdfs:label "species context qualifier" ;
    rdfs:domain biolink:Association ;
    rdfs:range biolink:OrganismTaxon ;
    rdfs:subPropertyOf biolink:statement_qualifier ;
    skos:definition "A statement qualifier representing a taxonomic category of species in which a relationship expressed in an association took place." ;
    skos:editorialNote "Ontology CURIEs are expected as values here, the examples below are intended to help clarify the content of the CURIEs." ;
    linkml:examples "Example(value='human', description=None)",
        "Example(value='zebrafish', description=None)" .

biolink:subject_direction_qualifier a owl:ObjectProperty ;
    rdfs:label "subject direction qualifier" ;
    rdfs:domain biolink:Association ;
    rdfs:range biolink:DirectionQualifierEnum ;
    rdfs:subPropertyOf biolink:direction_qualifier .

biolink:temporal_context_qualifier a owl:ObjectProperty ;
    rdfs:label "temporal context qualifier" ;
    rdfs:domain biolink:Association ;
    rdfs:range biolink:TimeType ;
    rdfs:subPropertyOf biolink:qualifier ;
    skos:definition "a constraint of time placed upon the truth value of an association. for time intervales, use temporal interval qualifier." .

biolink:temporally_related_to a owl:ObjectProperty,
        owl:SymmetricProperty ;
    rdfs:label "temporally related to" ;
    rdfs:domain biolink:Occurrent ;
    rdfs:range biolink:Occurrent ;
    rdfs:subPropertyOf biolink:related_to_at_instance_level ;
    skos:definition "holds between two entities with a temporal relationship" ;
    skos:exactMatch <http://purl.obolibrary.org/obo/SNOMED_temporally_related_to> ;
    skos:narrowMatch RO:0002082,
        RO:0002083,
        RO:0002092,
        RO:0002093,
        RO:0002223,
        RO:0002224,
        RO:0002229,
        RO:0002230,
        RO:0002488,
        RO:0002489,
        RO:0002492,
        RO:0002493,
        RO:0002496,
        RO:0002497 ;
    biolink:canonical_predicate "True" .

biolink:xref a owl:ObjectProperty ;
    rdfs:label "xref" ;
    rdfs:domain biolink:NamedThing ;
    rdfs:range linkml:Uriorcurie ;
    rdfs:subPropertyOf biolink:node_property ;
    skos:altLabel "DbXref",
        "Dbxref",
        "dbxref" ;
    skos:definition "Alternate CURIEs for a thing" ;
    skos:narrowMatch gff3:Dbxref,
        gpi:DB_Xrefs .

dct:source a owl:ObjectProperty ;
    rdfs:label "has dataset" ;
    rdfs:domain biolink:DatasetVersion ;
    rdfs:range biolink:Dataset ;
    rdfs:subPropertyOf biolink:node_property ;
    skos:exactMatch dct:source .

pav:version a owl:ObjectProperty ;
    rdfs:label "ingest date" ;
    rdfs:domain biolink:DatasetVersion ;
    rdfs:range linkml:String ;
    rdfs:subPropertyOf biolink:node_property ;
    skos:exactMatch pav:version .

biolink:ActivityAndBehavior a owl:Class ;
    rdfs:label "activity and behavior" ;
    rdfs:subClassOf biolink:Occurrent,
        linkml:mixin ;
    skos:definition "Activity or behavior of any independent integral living, organization or mechanical actor in the world" ;
    skos:exactMatch UMLSSG:ACTI .

biolink:CausalMechanismQualifierEnum a owl:Class ;
    rdfs:label "CausalMechanismQualifierEnum" ;
    owl:unionOf ( <https://w3id.org/biolink/vocab/CausalMechanismQualifierEnum#binding> <https://w3id.org/biolink/vocab/CausalMechanismQualifierEnum#inhibition> <https://w3id.org/biolink/vocab/CausalMechanismQualifierEnum#antibody_inhibition> <https://w3id.org/biolink/vocab/CausalMechanismQualifierEnum#antagonism> <https://w3id.org/biolink/vocab/CausalMechanismQualifierEnum#molecular_channel_blockage> <https://w3id.org/biolink/vocab/CausalMechanismQualifierEnum#inverse_agonism> <https://w3id.org/biolink/vocab/CausalMechanismQualifierEnum#negative_allosteric_modulation> <https://w3id.org/biolink/vocab/CausalMechanismQualifierEnum#agonism> <https://w3id.org/biolink/vocab/CausalMechanismQualifierEnum#molecular_channel_opening> <https://w3id.org/biolink/vocab/CausalMechanismQualifierEnum#positive_allosteric_modulation> <https://w3id.org/biolink/vocab/CausalMechanismQualifierEnum#potentiation> <https://w3id.org/biolink/vocab/CausalMechanismQualifierEnum#activation> <https://w3id.org/biolink/vocab/CausalMechanismQualifierEnum#inducer> <https://w3id.org/biolink/vocab/CausalMechanismQualifierEnum#transcriptional_regulation> <https://w3id.org/biolink/vocab/CausalMechanismQualifierEnum#signaling_mediated_control> <https://w3id.org/biolink/vocab/CausalMechanismQualifierEnum#stabilization> <https://w3id.org/biolink/vocab/CausalMechanismQualifierEnum#stimulation> <https://w3id.org/biolink/vocab/CausalMechanismQualifierEnum#releasing_activity> ) ;
    linkml:permissible_values <https://w3id.org/biolink/vocab/CausalMechanismQualifierEnum#activation>,
        <https://w3id.org/biolink/vocab/CausalMechanismQualifierEnum#agonism>,
        <https://w3id.org/biolink/vocab/CausalMechanismQualifierEnum#antagonism>,
        <https://w3id.org/biolink/vocab/CausalMechanismQualifierEnum#antibody_inhibition>,
        <https://w3id.org/biolink/vocab/CausalMechanismQualifierEnum#binding>,
        <https://w3id.org/biolink/vocab/CausalMechanismQualifierEnum#inducer>,
        <https://w3id.org/biolink/vocab/CausalMechanismQualifierEnum#inhibition>,
        <https://w3id.org/biolink/vocab/CausalMechanismQualifierEnum#inverse_agonism>,
        <https://w3id.org/biolink/vocab/CausalMechanismQualifierEnum#molecular_channel_blockage>,
        <https://w3id.org/biolink/vocab/CausalMechanismQualifierEnum#molecular_channel_opening>,
        <https://w3id.org/biolink/vocab/CausalMechanismQualifierEnum#negative_allosteric_modulation>,
        <https://w3id.org/biolink/vocab/CausalMechanismQualifierEnum#positive_allosteric_modulation>,
        <https://w3id.org/biolink/vocab/CausalMechanismQualifierEnum#potentiation>,
        <https://w3id.org/biolink/vocab/CausalMechanismQualifierEnum#releasing_activity>,
        <https://w3id.org/biolink/vocab/CausalMechanismQualifierEnum#signaling_mediated_control>,
        <https://w3id.org/biolink/vocab/CausalMechanismQualifierEnum#stabilization>,
        <https://w3id.org/biolink/vocab/CausalMechanismQualifierEnum#stimulation>,
        <https://w3id.org/biolink/vocab/CausalMechanismQualifierEnum#transcriptional_regulation> .

biolink:CellularComponent a owl:Class ;
    rdfs:label "cellular component" ;
    rdfs:subClassOf biolink:AnatomicalEntity ;
    skos:altLabel "cell component",
        "cell part" ;
    skos:broadMatch WIKIDATA:P681 ;
    skos:definition "A location in or around a cell" ;
    skos:exactMatch STY:T026,
        <http://purl.obolibrary.org/obo/GO_0005575>,
        SIO:001400,
        WIKIDATA:Q5058355 .

biolink:ChemicalEntityOrProteinOrPolypeptide a owl:Class ;
    rdfs:label "chemical entity or protein or polypeptide" ;
    rdfs:subClassOf linkml:mixin ;
    skos:definition "A union of chemical entities and children, and protein and polypeptide. This mixin is helpful to use when searching across chemical entities that must include genes and their children as chemical entities." .

biolink:ChemicalEntityToEntityAssociationMixin a owl:Class ;
    rdfs:label "chemical entity to entity association mixin" ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:onClass biolink:ChemicalEntityOrGeneOrGeneProduct ;
            owl:onProperty rdf:subject ;
            owl:qualifiedCardinality 1 ],
        linkml:mixin ;
    skos:definition "An interaction between a chemical entity and another entity" .

biolink:DatasetDistribution a owl:Class ;
    rdfs:label "dataset distribution" ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:maxQualifiedCardinality 1 ;
            owl:onClass linkml:String ;
            owl:onProperty biolink:distribution_download_url ],
        biolink:InformationContentEntity ;
    skos:definition "an item that holds distribution level information about a dataset." ;
    skos:exactMatch dcat:Distribution .

biolink:DatasetSummary a owl:Class ;
    rdfs:label "dataset summary" ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:maxQualifiedCardinality 1 ;
            owl:onClass linkml:String ;
            owl:onProperty biolink:source_web_page ],
        [ a owl:Restriction ;
            owl:maxQualifiedCardinality 1 ;
            owl:onClass linkml:String ;
            owl:onProperty schema:logo ],
        biolink:InformationContentEntity ;
    skos:definition "an item that holds summary level information about a dataset." .

biolink:DiseaseOrPhenotypicFeatureToEntityAssociationMixin a owl:Class ;
    rdfs:label "disease or phenotypic feature to entity association mixin" ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:onClass biolink:DiseaseOrPhenotypicFeature ;
            owl:onProperty rdf:subject ;
            owl:qualifiedCardinality 1 ],
        linkml:mixin .

biolink:DiseaseToEntityAssociationMixin a owl:Class ;
    rdfs:label "disease to entity association mixin" ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:onClass biolink:Disease ;
            owl:onProperty rdf:subject ;
            owl:qualifiedCardinality 1 ],
        linkml:mixin .

biolink:FDAApprovalStatusEnum a owl:Class ;
    rdfs:label "FDAApprovalStatusEnum" ;
    owl:unionOf ( <https://w3id.org/biolink/vocab/FDAApprovalStatusEnum#discovery_and_development_phase> <https://w3id.org/biolink/vocab/FDAApprovalStatusEnum#preclinical_research_phase> <https://w3id.org/biolink/vocab/FDAApprovalStatusEnum#fda_clinical_research_phase> <https://w3id.org/biolink/vocab/FDAApprovalStatusEnum#fda_review_phase_4> <https://w3id.org/biolink/vocab/FDAApprovalStatusEnum#fda_post_market_safety_review> <https://w3id.org/biolink/vocab/FDAApprovalStatusEnum#fda_clinical_research_phase_1> <https://w3id.org/biolink/vocab/FDAApprovalStatusEnum#fda_clinical_research_phase_2> <https://w3id.org/biolink/vocab/FDAApprovalStatusEnum#fda_clinical_research_phase_3> <https://w3id.org/biolink/vocab/FDAApprovalStatusEnum#fda_clinical_research_phase_4> <https://w3id.org/biolink/vocab/FDAApprovalStatusEnum#fda_fast_track> <https://w3id.org/biolink/vocab/FDAApprovalStatusEnum#fda_breakthrough_therapy> <https://w3id.org/biolink/vocab/FDAApprovalStatusEnum#fda_accelerated_approval> <https://w3id.org/biolink/vocab/FDAApprovalStatusEnum#fda_priority_review> <https://w3id.org/biolink/vocab/FDAApprovalStatusEnum#regular_fda_approval> <https://w3id.org/biolink/vocab/FDAApprovalStatusEnum#post_approval_withdrawal> ) ;
    linkml:permissible_values <https://w3id.org/biolink/vocab/FDAApprovalStatusEnum#discovery_and_development_phase>,
        <https://w3id.org/biolink/vocab/FDAApprovalStatusEnum#fda_accelerated_approval>,
        <https://w3id.org/biolink/vocab/FDAApprovalStatusEnum#fda_breakthrough_therapy>,
        <https://w3id.org/biolink/vocab/FDAApprovalStatusEnum#fda_clinical_research_phase>,
        <https://w3id.org/biolink/vocab/FDAApprovalStatusEnum#fda_clinical_research_phase_1>,
        <https://w3id.org/biolink/vocab/FDAApprovalStatusEnum#fda_clinical_research_phase_2>,
        <https://w3id.org/biolink/vocab/FDAApprovalStatusEnum#fda_clinical_research_phase_3>,
        <https://w3id.org/biolink/vocab/FDAApprovalStatusEnum#fda_clinical_research_phase_4>,
        <https://w3id.org/biolink/vocab/FDAApprovalStatusEnum#fda_fast_track>,
        <https://w3id.org/biolink/vocab/FDAApprovalStatusEnum#fda_post_market_safety_review>,
        <https://w3id.org/biolink/vocab/FDAApprovalStatusEnum#fda_priority_review>,
        <https://w3id.org/biolink/vocab/FDAApprovalStatusEnum#fda_review_phase_4>,
        <https://w3id.org/biolink/vocab/FDAApprovalStatusEnum#post_approval_withdrawal>,
        <https://w3id.org/biolink/vocab/FDAApprovalStatusEnum#preclinical_research_phase>,
        <https://w3id.org/biolink/vocab/FDAApprovalStatusEnum#regular_fda_approval> .

biolink:FrequencyQualifierMixin a owl:Class ;
    rdfs:label "frequency qualifier mixin" ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:maxQualifiedCardinality 1 ;
            owl:onClass biolink:FrequencyValue ;
            owl:onProperty biolink:frequency_qualifier ],
        linkml:mixin ;
    skos:definition "Qualifier for frequency type associations" .

biolink:GeneExpressionMixin a owl:Class ;
    rdfs:label "gene expression mixin" ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:maxQualifiedCardinality 1 ;
            owl:onClass biolink:DiseaseOrPhenotypicFeature ;
            owl:onProperty biolink:phenotypic_state ],
        [ a owl:Restriction ;
            owl:maxQualifiedCardinality 1 ;
            owl:onClass biolink:LifeStage ;
            owl:onProperty biolink:stage_qualifier ],
        [ a owl:Restriction ;
            owl:maxQualifiedCardinality 1 ;
            owl:onClass biolink:OntologyClass ;
            owl:onProperty biolink:quantifier_qualifier ],
        [ a owl:Restriction ;
            owl:maxQualifiedCardinality 1 ;
            owl:onClass biolink:AnatomicalEntity ;
            owl:onProperty biolink:expression_site ],
        linkml:mixin ;
    skos:definition "Observed gene expression intensity, context (site, stage) and associated phenotypic status within which the expression occurs." .

biolink:GeneToDiseaseAssociation a owl:Class ;
    rdfs:label "gene to disease association" ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:maxQualifiedCardinality 1 ;
            owl:onClass biolink:FrequencyValue ;
            owl:onProperty biolink:frequency_qualifier ],
        [ a owl:Restriction ;
            owl:maxQualifiedCardinality 1 ;
            owl:onClass biolink:SeverityValue ;
            owl:onProperty biolink:severity_qualifier ],
        [ a owl:Restriction ;
            owl:maxQualifiedCardinality 1 ;
            owl:onClass biolink:Onset ;
            owl:onProperty biolink:onset_qualifier ],
        [ a owl:Restriction ;
            owl:onClass biolink:GeneOrGeneProduct ;
            owl:onProperty rdf:subject ;
            owl:qualifiedCardinality 1 ],
        [ a owl:Restriction ;
            owl:onClass biolink:Disease ;
            owl:onProperty rdf:object ;
            owl:qualifiedCardinality 1 ],
        biolink:Association,
        biolink:EntityToDiseaseAssociationMixin,
        biolink:GeneToEntityAssociationMixin ;
    skos:closeMatch dcid:DiseaseGeneAssociation ;
    skos:exactMatch SIO:000983 ;
    skos:note "NCIT:R176 refers to the inverse relationship" .

biolink:GeneToGeneAssociation a owl:Class ;
    rdfs:label "gene to gene association" ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:onClass biolink:GeneOrGeneProduct ;
            owl:onProperty rdf:subject ;
            owl:qualifiedCardinality 1 ],
        [ a owl:Restriction ;
            owl:onClass biolink:GeneOrGeneProduct ;
            owl:onProperty rdf:object ;
            owl:qualifiedCardinality 1 ],
        biolink:Association ;
    skos:altLabel "molecular or genetic interaction" ;
    skos:definition "abstract parent class for different kinds of gene-gene or gene product to gene product relationships. Includes homology and interaction." .

biolink:GeneticInheritance a owl:Class ;
    rdfs:label "genetic inheritance" ;
    rdfs:subClassOf biolink:BiologicalEntity ;
    skos:altLabel "inheritance" ;
    skos:closeMatch STY:T045 ;
    skos:definition "The pattern or 'mode' in which a particular genetic trait or disorder is passed from one generation to the next, e.g. autosomal dominant, autosomal recessive, etc." ;
    skos:exactMatch <http://purl.obolibrary.org/obo/GENO_0000141>,
        <http://purl.obolibrary.org/obo/HP_0000005>,
        <http://purl.obolibrary.org/obo/NCIT_C45827> .

biolink:GenotypeToEntityAssociationMixin a owl:Class ;
    rdfs:label "genotype to entity association mixin" ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:onClass biolink:Genotype ;
            owl:onProperty rdf:subject ;
            owl:qualifiedCardinality 1 ],
        linkml:mixin .

biolink:IndividualOrganism a owl:Class ;
    rdfs:label "individual organism" ;
    rdfs:subClassOf biolink:OrganismalEntity,
        biolink:SubjectOfInvestigation ;
    skos:altLabel "organism" ;
    skos:definition "An instance of an organism. For example, Richard Nixon, Charles Darwin, my pet cat. Example ID: ORCID:0000-0002-5355-2576" ;
    skos:exactMatch STY:T001,
        SIO:010000 ;
    skos:narrowMatch foaf:Person,
        WIKIDATA:Q795052 .

biolink:OrganismTaxonToEntityAssociation a owl:Class ;
    rdfs:label "organism taxon to entity association" ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:onClass biolink:OrganismTaxon ;
            owl:onProperty rdf:subject ;
            owl:qualifiedCardinality 1 ],
        linkml:mixin ;
    skos:definition "An association between an organism taxon and another entity" .

biolink:Pathway a owl:Class ;
    rdfs:label "pathway" ;
    rdfs:subClassOf biolink:BiologicalProcess,
        biolink:OntologyClass ;
    skos:exactMatch <http://purl.obolibrary.org/obo/PW_0000001>,
        WIKIDATA:Q4915012 ;
    skos:narrowMatch <http://purl.obolibrary.org/obo/GO_0007165>,
        SIO:010526 .

biolink:PlanetaryEntity a owl:Class ;
    rdfs:label "planetary entity" ;
    rdfs:subClassOf biolink:NamedThing ;
    skos:definition "Any entity or process that exists at the level of the whole planet" .

biolink:PredicateMapping a owl:Class ;
    rdfs:label "predicate mapping" ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:maxQualifiedCardinality 1 ;
            owl:onClass biolink:DirectionQualifierEnum ;
            owl:onProperty biolink:subject_direction_qualifier ],
        [ a owl:Restriction ;
            owl:maxQualifiedCardinality 1 ;
            owl:onClass linkml:String ;
            owl:onProperty biolink:object_context_qualifier ],
        [ a owl:Restriction ;
            owl:maxQualifiedCardinality 1 ;
            owl:onClass linkml:String ;
            owl:onProperty biolink:object_derivative_qualifier ],
        [ a owl:Restriction ;
            owl:maxQualifiedCardinality 1 ;
            owl:onClass biolink:CausalMechanismQualifierEnum ;
            owl:onProperty biolink:causal_mechanism_qualifier ],
        [ a owl:Restriction ;
            owl:maxQualifiedCardinality 1 ;
            owl:onClass linkml:String ;
            owl:onProperty biolink:subject_derivative_qualifier ],
        [ a owl:Restriction ;
            owl:allValuesFrom biolink:NamedThing ;
            owl:onProperty biolink:exact_match ],
        [ a owl:Restriction ;
            owl:maxQualifiedCardinality 1 ;
            owl:onClass biolink:DirectionQualifierEnum ;
            owl:onProperty biolink:object_direction_qualifier ],
        [ a owl:Restriction ;
            owl:maxQualifiedCardinality 1 ;
            owl:onClass biolink:AnatomicalContextQualifierEnum ;
            owl:onProperty biolink:anatomical_context_qualifier ],
        [ a owl:Restriction ;
            owl:allValuesFrom biolink:NamedThing ;
            owl:onProperty biolink:broad_match ],
        [ a owl:Restriction ;
            owl:maxQualifiedCardinality 1 ;
            owl:onClass linkml:String ;
            owl:onProperty biolink:qualified_predicate ],
        [ a owl:Restriction ;
            owl:maxQualifiedCardinality 1 ;
            owl:onClass linkml:String ;
            owl:onProperty biolink:mapped_predicate ],
        [ a owl:Restriction ;
            owl:onClass biolink:PredicateType ;
            owl:onProperty rdf:predicate ;
            owl:qualifiedCardinality 1 ],
        [ a owl:Restriction ;
            owl:maxQualifiedCardinality 1 ;
            owl:onClass linkml:String ;
            owl:onProperty biolink:object_part_qualifier ],
        [ a owl:Restriction ;
            owl:maxQualifiedCardinality 1 ;
            owl:onClass linkml:String ;
            owl:onProperty biolink:object_aspect_qualifier ],
        [ a owl:Restriction ;
            owl:allValuesFrom biolink:NamedThing ;
            owl:onProperty biolink:narrow_match ],
        [ a owl:Restriction ;
            owl:maxQualifiedCardinality 1 ;
            owl:onClass linkml:String ;
            owl:onProperty biolink:subject_context_qualifier ],
        [ a owl:Restriction ;
            owl:maxQualifiedCardinality 1 ;
            owl:onClass linkml:String ;
            owl:onProperty biolink:subject_part_qualifier ],
        [ a owl:Restriction ;
            owl:maxQualifiedCardinality 1 ;
            owl:onClass linkml:String ;
            owl:onProperty biolink:subject_form_or_variant_qualifier ],
        [ a owl:Restriction ;
            owl:maxQualifiedCardinality 1 ;
            owl:onClass linkml:String ;
            owl:onProperty biolink:subject_aspect_qualifier ],
        [ a owl:Restriction ;
            owl:maxQualifiedCardinality 1 ;
            owl:onClass linkml:String ;
            owl:onProperty biolink:object_form_or_variant_qualifier ],
        [ a owl:Restriction ;
            owl:maxQualifiedCardinality 1 ;
            owl:onClass biolink:OrganismTaxon ;
            owl:onProperty biolink:species_context_qualifier ] ;
    skos:definition "A deprecated predicate mapping object contains the deprecated predicate and an example of the rewiring that should be done to use a qualified statement in its place." .

biolink:Protein a owl:Class ;
    rdfs:label "protein" ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:allValuesFrom biolink:LabelType ;
            owl:onProperty biolink:synonym ],
        biolink:GeneProductMixin,
        biolink:Polypeptide ;
    skos:broadMatch bioschemas:Protein ;
    skos:definition "A gene product that is composed of a chain of amino acid sequences and is produced by ribosome-mediated translation of mRNA" ;
    skos:exactMatch <http://purl.obolibrary.org/obo/PR_000000001>,
        SIO:010043,
        WIKIDATA:Q8054 ;
    skos:narrowMatch STY:T126,
        STY:T192 .

biolink:SequenceFeatureRelationship a owl:Class ;
    rdfs:label "sequence feature relationship" ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:onClass biolink:NucleicAcidEntity ;
            owl:onProperty rdf:subject ;
            owl:qualifiedCardinality 1 ],
        [ a owl:Restriction ;
            owl:onClass biolink:NucleicAcidEntity ;
            owl:onProperty rdf:object ;
            owl:qualifiedCardinality 1 ],
        biolink:Association ;
    skos:definition "For example, a particular exon is part of a particular transcript or gene" ;
    skos:exactMatch CHADO:feature_relationship .

biolink:acts_upstream_of_or_within a owl:ObjectProperty ;
    rdfs:label "acts upstream of or within" ;
    rdfs:domain biolink:GeneOrGeneProduct ;
    rdfs:range biolink:BiologicalProcess ;
    rdfs:subPropertyOf biolink:acts_upstream_of ;
    owl:inverseOf biolink:has_upstream_or_within_actor ;
    skos:exactMatch RO:0002264 ;
    biolink:canonical_predicate "True" .

biolink:affects_response_to a owl:ObjectProperty ;
    rdfs:label "affects response to" ;
    rdfs:domain biolink:ChemicalEntityOrGeneOrGeneProduct ;
    rdfs:range biolink:ChemicalEntityOrGeneOrGeneProduct ;
    rdfs:subPropertyOf biolink:affects ;
    owl:inverseOf biolink:response_affected_by ;
    skos:exactMatch CTD:affects_response_to ;
    biolink:canonical_predicate "True" .

biolink:affects_risk_for a owl:ObjectProperty ;
    rdfs:label "affects risk for" ;
    rdfs:domain biolink:NamedThing ;
    rdfs:range biolink:NamedThing ;
    rdfs:subPropertyOf biolink:related_to_at_instance_level ;
    owl:inverseOf biolink:risk_affected_by ;
    skos:definition "holds between two entities where exposure to one entity alters the chance of developing the other" ;
    biolink:canonical_predicate "True" .

biolink:anatomical_context_qualifier a owl:ObjectProperty ;
    rdfs:label "anatomical context qualifier" ;
    rdfs:domain biolink:Association ;
    rdfs:range biolink:AnatomicalContextQualifierEnum ;
    rdfs:subPropertyOf biolink:statement_qualifier ;
    skos:definition "A statement qualifier representing an anatomical location where an relationship expressed in an association took place (can be a tissue, cell type, or sub-cellular location)." ;
    skos:editorialNote "Anatomical context values can be any term from UBERON. For example, the context qualifier ‘cerebral cortext’  combines with a core concept of ‘neuron’  to express the composed concept ‘neuron in the cerebral cortext’. The species_context_qualifier applies  taxonomic context, e.g. species-specific molecular activity.  Ontology CURIEs are expected as values  here, the examples below are intended to help clarify the content of the CURIEs." ;
    linkml:examples "Example(value='blood', description=None)",
        "Example(value='cerebral cortext', description=None)" .

biolink:associated_with_likelihood_of a owl:ObjectProperty ;
    rdfs:label "associated with likelihood of" ;
    rdfs:domain biolink:NamedThing ;
    rdfs:range biolink:NamedThing ;
    rdfs:subPropertyOf biolink:associated_with ;
    owl:inverseOf biolink:likelihood_associated_with ;
    skos:definition "A a relationship that holds between two concepts represented by variables for which a statistical  dependence is demonstrated, wherein the state or value of one variable predicts the future state  or value of the other.  E.g. the statement “An Atrial Fibrillation (Afib) diagnosis is associated  with likelihood of a Myocardial Infarction (MI) diagnosis” asserts that the state of having Afib  is associated with an increased or decreased likelihood that a patient will later exhibit MI." ;
    biolink:canonical_predicate "True" .

biolink:enabled_by a owl:ObjectProperty ;
    rdfs:label "enabled by" ;
    rdfs:domain biolink:BiologicalProcessOrActivity ;
    rdfs:range biolink:PhysicalEntity ;
    rdfs:subPropertyOf biolink:has_participant ;
    owl:inverseOf biolink:enables ;
    skos:definition "holds between a process and a physical entity, where the physical entity executes the process" ;
    skos:exactMatch RO:0002333 ;
    biolink:opposite_of "prevented by" .

biolink:expression_site a owl:ObjectProperty ;
    rdfs:label "expression site" ;
    rdfs:domain biolink:Association ;
    rdfs:range biolink:AnatomicalEntity ;
    rdfs:subPropertyOf biolink:association_slot ;
    skos:definition "location in which gene or protein expression takes place. May be cell, tissue, or organ." ;
    linkml:examples "Example(value='UBERON:0002037', description='cerebellum')" .

biolink:has_output a owl:ObjectProperty ;
    rdfs:label "has output" ;
    rdfs:domain biolink:BiologicalProcessOrActivity ;
    rdfs:range biolink:Occurrent ;
    rdfs:subPropertyOf biolink:has_participant ;
    owl:inverseOf biolink:is_output_of ;
    skos:closeMatch RO:0002353,
        RO:0002354 ;
    skos:definition "holds between a process and a continuant, where the continuant is an output of the process" ;
    skos:exactMatch RO:0002234 ;
    skos:narrowMatch <http://purl.obolibrary.org/obo/NCIT_R31>,
        <http://purl.obolibrary.org/obo/OBI_0000299>,
        RO:0002296,
        RO:0002297,
        RO:0002298,
        RO:0002299,
        RO:0002588,
        RO:0004008,
        PathWhiz:has_right_element ;
    biolink:canonical_predicate "True" ;
    biolink:opposite_of "has input" .

biolink:has_upstream_or_within_actor a owl:ObjectProperty ;
    rdfs:label "has upstream or within actor" ;
    rdfs:domain biolink:BiologicalProcess ;
    rdfs:range biolink:GeneOrGeneProduct ;
    rdfs:subPropertyOf biolink:has_upstream_actor ;
    owl:inverseOf biolink:acts_upstream_of_or_within .

biolink:homologous_to a owl:ObjectProperty,
        owl:SymmetricProperty ;
    rdfs:label "homologous to" ;
    rdfs:domain biolink:NamedThing ;
    rdfs:range biolink:NamedThing ;
    rdfs:subPropertyOf biolink:similar_to ;
    skos:altLabel "in homology relationship with" ;
    skos:definition "holds between two biological entities that have common evolutionary origin" ;
    skos:exactMatch RO:HOM0000001,
        SIO:010302 ;
    skos:narrowMatch UBERON_CORE:sexually_homologous_to ;
    skos:note "typically used to describe homology relationships between genes or gene products" ;
    biolink:canonical_predicate "True" .

biolink:interacts_with a owl:ObjectProperty,
        owl:SymmetricProperty ;
    rdfs:label "interacts with" ;
    rdfs:domain biolink:NamedThing ;
    rdfs:range biolink:NamedThing ;
    rdfs:subPropertyOf biolink:related_to_at_instance_level ;
    skos:definition "holds between any two entities that directly or indirectly interact with each other" ;
    skos:editorialNote "please use a more specific child predicate of interacts with, either physically interacts with or genetically interacts with. " ;
    skos:exactMatch SEMMEDDB:INTERACTS_WITH .

biolink:knowledge_source a owl:ObjectProperty ;
    rdfs:label "knowledge source" ;
    rdfs:domain biolink:Association ;
    rdfs:range biolink:InformationResource ;
    rdfs:subPropertyOf biolink:association_slot ;
    skos:closeMatch pav:providedBy ;
    skos:definition "An Information Resource from which the knowledge expressed in an Association was retrieved, directly or indirectly. This can be any resource through which the knowledge passed on its way to its currently serialized form. In practice, implementers should use one of the more specific subtypes of this generic property." .

biolink:likelihood_associated_with a owl:ObjectProperty ;
    rdfs:label "likelihood associated with" ;
    rdfs:domain biolink:NamedThing ;
    rdfs:range biolink:NamedThing ;
    rdfs:subPropertyOf biolink:associated_with ;
    owl:inverseOf biolink:associated_with_likelihood_of ;
    skos:definition "" .

biolink:object_aspect_qualifier a owl:ObjectProperty ;
    rdfs:label "object aspect qualifier" ;
    rdfs:domain biolink:Association ;
    rdfs:range linkml:String ;
    rdfs:subPropertyOf biolink:aspect_qualifier .

biolink:object_direction_qualifier a owl:ObjectProperty ;
    rdfs:label "object direction qualifier" ;
    rdfs:domain biolink:Association ;
    rdfs:range biolink:DirectionQualifierEnum ;
    rdfs:subPropertyOf biolink:direction_qualifier .

biolink:object_form_or_variant_qualifier a owl:ObjectProperty ;
    rdfs:label "object form or variant qualifier" ;
    rdfs:domain biolink:Association ;
    rdfs:range linkml:String ;
    rdfs:subPropertyOf biolink:form_or_variant_qualifier .

biolink:object_part_qualifier a owl:ObjectProperty ;
    rdfs:label "object part qualifier" ;
    rdfs:domain biolink:Association ;
    rdfs:range linkml:String ;
    rdfs:subPropertyOf biolink:part_qualifier .

biolink:phenotypic_state a owl:ObjectProperty ;
    rdfs:label "phenotypic state" ;
    rdfs:domain biolink:Association ;
    rdfs:range biolink:DiseaseOrPhenotypicFeature ;
    rdfs:subPropertyOf biolink:association_slot ;
    skos:definition "in experiments (e.g. gene expression) assaying diseased or unhealthy tissue, the phenotypic state can be put here, e.g. MONDO ID. For healthy tissues, use XXX." .

biolink:response_affected_by a owl:ObjectProperty ;
    rdfs:label "response affected by" ;
    rdfs:domain biolink:ChemicalEntityOrGeneOrGeneProduct ;
    rdfs:range biolink:ChemicalEntityOrGeneOrGeneProduct ;
    rdfs:subPropertyOf biolink:affected_by ;
    owl:inverseOf biolink:affects_response_to ;
    skos:definition "holds between two chemical entities where the susceptibility of a biological entity or system (e.g. an organism, cell, cellular component, macromolecular machine mixin, biological or pathological process) of one is affected by the action of the other." .

biolink:risk_affected_by a owl:ObjectProperty ;
    rdfs:label "risk affected by" ;
    rdfs:domain biolink:NamedThing ;
    rdfs:range biolink:NamedThing ;
    rdfs:subPropertyOf biolink:related_to_at_instance_level ;
    owl:inverseOf biolink:affects_risk_for .

biolink:statement_qualifier a owl:ObjectProperty ;
    rdfs:label "statement qualifier" ;
    rdfs:domain biolink:Association ;
    rdfs:range linkml:String ;
    rdfs:subPropertyOf biolink:qualifier ;
    skos:definition "" .

biolink:subject_aspect_qualifier a owl:ObjectProperty ;
    rdfs:label "subject aspect qualifier" ;
    rdfs:domain biolink:Association ;
    rdfs:range linkml:String ;
    rdfs:subPropertyOf biolink:aspect_qualifier .

biolink:subject_derivative_qualifier a owl:ObjectProperty ;
    rdfs:label "subject derivative qualifier" ;
    rdfs:domain biolink:Association ;
    rdfs:range linkml:String ;
    rdfs:subPropertyOf biolink:derivative_qualifier .

biolink:subject_part_qualifier a owl:ObjectProperty ;
    rdfs:label "subject part qualifier" ;
    rdfs:domain biolink:Association ;
    rdfs:range linkml:String ;
    rdfs:subPropertyOf biolink:part_qualifier .

biolink:volume a owl:ObjectProperty ;
    rdfs:label "volume" ;
    rdfs:domain biolink:Publication ;
    rdfs:range linkml:String ;
    rdfs:subPropertyOf biolink:node_property ;
    skos:definition "volume of a book or music release in a collection/series or a published collection of journal issues in a serial publication" ;
    skos:exactMatch WIKIDATA_PROPERTY:P478 .

biolink:ChemicalOrGeneOrGeneProductFormOrVariantEnum a owl:Class ;
    rdfs:label "ChemicalOrGeneOrGeneProductFormOrVariantEnum" ;
    owl:unionOf ( <https://w3id.org/biolink/vocab/ChemicalOrGeneOrGeneProductFormOrVariantEnum#genetic_variant_form> <https://w3id.org/biolink/vocab/ChemicalOrGeneOrGeneProductFormOrVariantEnum#modified_form> <https://w3id.org/biolink/vocab/ChemicalOrGeneOrGeneProductFormOrVariantEnum#loss_of_function_variant_form> <https://w3id.org/biolink/vocab/ChemicalOrGeneOrGeneProductFormOrVariantEnum#gain_of_function_variant_form> <https://w3id.org/biolink/vocab/ChemicalOrGeneOrGeneProductFormOrVariantEnum#polymorphic_form> <https://w3id.org/biolink/vocab/ChemicalOrGeneOrGeneProductFormOrVariantEnum#snp_form> <https://w3id.org/biolink/vocab/ChemicalOrGeneOrGeneProductFormOrVariantEnum#analog_form> ) ;
    linkml:permissible_values <https://w3id.org/biolink/vocab/ChemicalOrGeneOrGeneProductFormOrVariantEnum#analog_form>,
        <https://w3id.org/biolink/vocab/ChemicalOrGeneOrGeneProductFormOrVariantEnum#gain_of_function_variant_form>,
        <https://w3id.org/biolink/vocab/ChemicalOrGeneOrGeneProductFormOrVariantEnum#genetic_variant_form>,
        <https://w3id.org/biolink/vocab/ChemicalOrGeneOrGeneProductFormOrVariantEnum#loss_of_function_variant_form>,
        <https://w3id.org/biolink/vocab/ChemicalOrGeneOrGeneProductFormOrVariantEnum#modified_form>,
        <https://w3id.org/biolink/vocab/ChemicalOrGeneOrGeneProductFormOrVariantEnum#polymorphic_form>,
        <https://w3id.org/biolink/vocab/ChemicalOrGeneOrGeneProductFormOrVariantEnum#snp_form> .

biolink:ClinicalAttribute a owl:Class ;
    rdfs:label "clinical attribute" ;
    rdfs:subClassOf biolink:Attribute ;
    skos:definition "Attributes relating to a clinical manifestation" ;
    skos:exactMatch STY:T201 .

biolink:DatasetVersion a owl:Class ;
    rdfs:label "dataset version" ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:maxQualifiedCardinality 1 ;
            owl:onClass biolink:Dataset ;
            owl:onProperty dct:source ],
        [ a owl:Restriction ;
            owl:maxQualifiedCardinality 1 ;
            owl:onClass linkml:String ;
            owl:onProperty pav:version ],
        [ a owl:Restriction ;
            owl:maxQualifiedCardinality 1 ;
            owl:onClass biolink:DatasetDistribution ;
            owl:onProperty dct:distribution ],
        biolink:InformationContentEntity ;
    skos:definition "an item that holds version level information about a dataset." .

biolink:FunctionalAssociation a owl:Class ;
    rdfs:label "functional association" ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:onClass biolink:MacromolecularMachineMixin ;
            owl:onProperty rdf:subject ;
            owl:qualifiedCardinality 1 ],
        [ a owl:Restriction ;
            owl:onClass biolink:OntologyClass ;
            owl:onProperty rdf:object ;
            owl:qualifiedCardinality 1 ],
        biolink:Association ;
    skos:definition "An association between a macromolecular machine mixin (gene, gene product or complex of gene products) and either a molecular activity, a biological process or a cellular location in which a function is executed." .

biolink:GeneProductIsoformMixin a owl:Class ;
    rdfs:label "gene product isoform mixin" ;
    rdfs:subClassOf biolink:GeneProductMixin,
        linkml:mixin ;
    skos:definition "This is an abstract class that can be mixed in with different kinds of gene products to indicate that the gene product is intended to represent a specific isoform rather than a canonical or reference or generic product. The designation of canonical or reference may be arbitrary, or it may represent the superclass of all isoforms." .

biolink:MacromolecularMachineToEntityAssociationMixin a owl:Class ;
    rdfs:label "macromolecular machine to entity association mixin" ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:onClass biolink:NamedThing ;
            owl:onProperty rdf:subject ;
            owl:qualifiedCardinality 1 ],
        linkml:mixin ;
    skos:definition "an association which has a macromolecular machine mixin as a subject" .

biolink:PathologicalEntityMixin a owl:Class ;
    rdfs:label "pathological entity mixin" ;
    rdfs:subClassOf linkml:mixin ;
    skos:definition "A pathological (abnormal) structure or process." ;
    skos:exactMatch <http://purl.obolibrary.org/obo/MPATH_0> ;
    skos:narrowMatch <http://purl.obolibrary.org/obo/HP_0000118> .

biolink:PhysicalEntity a owl:Class ;
    rdfs:label "physical entity" ;
    rdfs:subClassOf biolink:NamedThing,
        biolink:PhysicalEssence ;
    skos:definition "An entity that has material reality (a.k.a. physical essence)." ;
    skos:exactMatch STY:T072 ;
    skos:narrowMatch STY:T073 .

biolink:QuantityValue a owl:Class ;
    rdfs:label "quantity value" ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:maxQualifiedCardinality 1 ;
            owl:onClass linkml:Double ;
            owl:onProperty biolink:has_numeric_value ],
        [ a owl:Restriction ;
            owl:maxQualifiedCardinality 1 ;
            owl:onClass biolink:Unit ;
            owl:onProperty biolink:has_unit ],
        biolink:Annotation ;
    skos:definition "A value of an attribute that is quantitative and measurable, expressed as a combination of a unit and a numeric value" .

biolink:RelationshipQuantifier a owl:Class ;
    rdfs:label "relationship quantifier" ;
    rdfs:subClassOf linkml:mixin .

biolink:StrandEnum a owl:Class ;
    rdfs:label "StrandEnum" ;
    owl:unionOf ( <https://w3id.org/biolink/vocab/StrandEnum#+> <https://w3id.org/biolink/vocab/StrandEnum#-> <https://w3id.org/biolink/vocab/StrandEnum#.> <https://w3id.org/biolink/vocab/StrandEnum#?> ) ;
    linkml:permissible_values <https://w3id.org/biolink/vocab/StrandEnum#+>,
        <https://w3id.org/biolink/vocab/StrandEnum#->,
        <https://w3id.org/biolink/vocab/StrandEnum#.>,
        <https://w3id.org/biolink/vocab/StrandEnum#?> .

biolink:acts_upstream_of a owl:ObjectProperty ;
    rdfs:label "acts upstream of" ;
    rdfs:domain biolink:GeneOrGeneProduct ;
    rdfs:range biolink:BiologicalProcess ;
    rdfs:subPropertyOf biolink:related_to_at_instance_level ;
    owl:inverseOf biolink:has_upstream_actor ;
    skos:exactMatch RO:0002263 ;
    biolink:canonical_predicate "True" .

biolink:aggregate_statistic a owl:ObjectProperty ;
    rdfs:label "aggregate statistic" ;
    rdfs:domain biolink:NamedThing ;
    rdfs:range linkml:String ;
    rdfs:subPropertyOf biolink:node_property .

biolink:category a owl:ObjectProperty ;
    rdfs:label "category" ;
    rdfs:domain biolink:Entity ;
    rdfs:range biolink:CategoryType ;
    rdfs:subPropertyOf rdf:type ;
    skos:definition """Name of the high level ontology class in which this entity is categorized. Corresponds to the label for the biolink entity type class.
 * In a neo4j database this MAY correspond to the neo4j label tag.
 * In an RDF database it should be a biolink model class URI.
This field is multi-valued. It should include values for ancestors of the biolink class; for example, a protein such as Shh would have category values `biolink:Protein`, `biolink:GeneProduct`, `biolink:MolecularEntity`, ...
In an RDF database, nodes will typically have an rdf:type triples. This can be to the most specific biolink class, or potentially to a class more specific than something in biolink. For example, a sequence feature `f` may have a rdf:type assertion to a SO class such as TF_binding_site, which is more specific than anything in biolink. Here we would have categories {biolink:GenomicEntity, biolink:MolecularEntity, biolink:NamedThing}""" .

biolink:coexists_with a owl:ObjectProperty,
        owl:SymmetricProperty ;
    rdfs:label "coexists with" ;
    rdfs:domain biolink:NamedThing ;
    rdfs:range biolink:NamedThing ;
    rdfs:subPropertyOf biolink:related_to_at_instance_level ;
    skos:definition "holds between two entities that are co-located in the same aggregate object, process, or spatio-temporal region" ;
    skos:exactMatch SEMMEDDB:COEXISTS_WITH ;
    skos:narrowMatch LOINC:has_lateral_anatomic_location,
        LOINC:has_lateral_location_presence,
        <http://purl.obolibrary.org/obo/BSPO_0000096>,
        <http://purl.obolibrary.org/obo/BSPO_0000097>,
        <http://purl.obolibrary.org/obo/BSPO_0000098>,
        <http://purl.obolibrary.org/obo/BSPO_0000099>,
        <http://purl.obolibrary.org/obo/BSPO_0000100>,
        <http://purl.obolibrary.org/obo/BSPO_0000102>,
        <http://purl.obolibrary.org/obo/BSPO_0000104>,
        <http://purl.obolibrary.org/obo/BSPO_0000110>,
        <http://purl.obolibrary.org/obo/BSPO_0000113>,
        <http://purl.obolibrary.org/obo/BSPO_0015001>,
        <http://purl.obolibrary.org/obo/BSPO_0015002>,
        <http://purl.obolibrary.org/obo/BSPO_0015003>,
        <http://purl.obolibrary.org/obo/BSPO_0015005>,
        <http://purl.obolibrary.org/obo/BSPO_0015006>,
        <http://purl.obolibrary.org/obo/BSPO_0015007>,
        <http://purl.obolibrary.org/obo/BSPO_0015008>,
        <http://purl.obolibrary.org/obo/BSPO_0015009>,
        <http://purl.obolibrary.org/obo/BSPO_0015012>,
        <http://purl.obolibrary.org/obo/BSPO_0015014>,
        <http://purl.obolibrary.org/obo/BSPO_parallel_to>,
        <http://purl.obolibrary.org/obo/ENVO_01001307>,
        <http://purl.obolibrary.org/obo/FMA_adjacent_to>,
        <http://purl.obolibrary.org/obo/FMA_afferent_to>,
        <http://purl.obolibrary.org/obo/FMA_anterior_to>,
        <http://purl.obolibrary.org/obo/FMA_anteroinferior_to>,
        <http://purl.obolibrary.org/obo/FMA_anterolateral_to>,
        <http://purl.obolibrary.org/obo/FMA_anteromedial_to>,
        <http://purl.obolibrary.org/obo/FMA_anterosuperior_to>,
        <http://purl.obolibrary.org/obo/FMA_arterial_supply_of>,
        <http://purl.obolibrary.org/obo/FMA_articulates_with>,
        <http://purl.obolibrary.org/obo/FMA_attaches_to>,
        <http://purl.obolibrary.org/obo/FMA_bounded_by>,
        <http://purl.obolibrary.org/obo/FMA_bounds>,
        <http://purl.obolibrary.org/obo/FMA_branch_of>,
        <http://purl.obolibrary.org/obo/FMA_connection_type_of>,
        <http://purl.obolibrary.org/obo/FMA_continuation_branch_of>,
        <http://purl.obolibrary.org/obo/FMA_continuous_distally_with>,
        <http://purl.obolibrary.org/obo/FMA_continuous_proximally_with>,
        <http://purl.obolibrary.org/obo/FMA_corresponds_to>,
        <http://purl.obolibrary.org/obo/FMA_development_type_of>,
        <http://purl.obolibrary.org/obo/FMA_developmental_stage_of>,
        <http://purl.obolibrary.org/obo/FMA_direct_cell_shape_of>,
        <http://purl.obolibrary.org/obo/FMA_direct_left_of>,
        <http://purl.obolibrary.org/obo/FMA_direct_right_of>,
        <http://purl.obolibrary.org/obo/FMA_distal_to>,
        <http://purl.obolibrary.org/obo/FMA_drains_into>,
        <http://purl.obolibrary.org/obo/FMA_efferent_to>,
        <http://purl.obolibrary.org/obo/FMA_external_to>,
        <http://purl.obolibrary.org/obo/FMA_formed_by>,
        <http://purl.obolibrary.org/obo/FMA_forms>,
        <http://purl.obolibrary.org/obo/FMA_full_grown_phenotype_of>,
        <http://purl.obolibrary.org/obo/FMA_fuses_with>,
        <http://purl.obolibrary.org/obo/FMA_fusion_of>,
        <http://purl.obolibrary.org/obo/FMA_germ_origin_of>,
        <http://purl.obolibrary.org/obo/FMA_has_adherent>,
        <http://purl.obolibrary.org/obo/FMA_has_arterial_supply>,
        <http://purl.obolibrary.org/obo/FMA_has_branch>,
        <http://purl.obolibrary.org/obo/FMA_has_connection_type>,
        <http://purl.obolibrary.org/obo/FMA_has_continuation_branch>,
        <http://purl.obolibrary.org/obo/FMA_has_development_type>,
        <http://purl.obolibrary.org/obo/FMA_has_developmental_stage>,
        <http://purl.obolibrary.org/obo/FMA_has_direct_cell_shape>,
        <http://purl.obolibrary.org/obo/FMA_has_full_grown_phenotype>,
        <http://purl.obolibrary.org/obo/FMA_has_fusion>,
        <http://purl.obolibrary.org/obo/FMA_has_germ_origin>,
        <http://purl.obolibrary.org/obo/FMA_has_inherent_3d_shape>,
        <http://purl.obolibrary.org/obo/FMA_has_insertion>,
        <http://purl.obolibrary.org/obo/FMA_has_lymphatic_drainage>,
        <http://purl.obolibrary.org/obo/FMA_has_nerve_supply>,
        <http://purl.obolibrary.org/obo/FMA_has_observed_anatomical_entity>,
        <http://purl.obolibrary.org/obo/FMA_has_origin>,
        <http://purl.obolibrary.org/obo/FMA_has_primary_segmental_supply>,
        <http://purl.obolibrary.org/obo/FMA_has_projection>,
        <http://purl.obolibrary.org/obo/FMA_has_regional_part>,
        <http://purl.obolibrary.org/obo/FMA_has_related_developmental_entity>,
        <http://purl.obolibrary.org/obo/FMA_has_secondary_segmental_supply>,
        <http://purl.obolibrary.org/obo/FMA_has_segmental_composition>,
        <http://purl.obolibrary.org/obo/FMA_has_segmental_supply>,
        <http://purl.obolibrary.org/obo/FMA_has_tributary>,
        <http://purl.obolibrary.org/obo/FMA_has_venous_drainage>,
        <http://purl.obolibrary.org/obo/FMA_inferior_to>,
        <http://purl.obolibrary.org/obo/FMA_inferolateral_to>,
        <http://purl.obolibrary.org/obo/FMA_inferomedial_to>,
        <http://purl.obolibrary.org/obo/FMA_inherent_3d_shape_of>,
        <http://purl.obolibrary.org/obo/FMA_insertion_of>,
        <http://purl.obolibrary.org/obo/FMA_internal_to>,
        <http://purl.obolibrary.org/obo/FMA_lateral_to>,
        <http://purl.obolibrary.org/obo/FMA_left_lateral_to>,
        <http://purl.obolibrary.org/obo/FMA_left_medial_to>,
        <http://purl.obolibrary.org/obo/FMA_lymphatic_drainage_of>,
        <http://purl.obolibrary.org/obo/FMA_matures_from>,
        <http://purl.obolibrary.org/obo/FMA_matures_into>,
        <http://purl.obolibrary.org/obo/FMA_medial_to>,
        <http://purl.obolibrary.org/obo/FMA_merges_with>,
        <http://purl.obolibrary.org/obo/FMA_nerve_supply_of>,
        <http://purl.obolibrary.org/obo/FMA_origin_of>,
        <http://purl.obolibrary.org/obo/FMA_posterior_to>,
        <http://purl.obolibrary.org/obo/FMA_posteroinferior_to>,
        <http://purl.obolibrary.org/obo/FMA_posterolateral_to>,
        <http://purl.obolibrary.org/obo/FMA_posteromedial_to>,
        <http://purl.obolibrary.org/obo/FMA_posterosuperior_to>,
        <http://purl.obolibrary.org/obo/FMA_primary_segmental_supply_of>,
        <http://purl.obolibrary.org/obo/FMA_projects_from>,
        <http://purl.obolibrary.org/obo/FMA_projects_to>,
        <http://purl.obolibrary.org/obo/FMA_proximal_to>,
        <http://purl.obolibrary.org/obo/FMA_receives_attachment_from>,
        <http://purl.obolibrary.org/obo/FMA_receives_drainage_from>,
        <http://purl.obolibrary.org/obo/FMA_receives_input_from>,
        <http://purl.obolibrary.org/obo/FMA_receives_projection>,
        <http://purl.obolibrary.org/obo/FMA_related_part>,
        <http://purl.obolibrary.org/obo/FMA_right_lateral_to>,
        <http://purl.obolibrary.org/obo/FMA_right_medial_to>,
        <http://purl.obolibrary.org/obo/FMA_secondary_segmental_supply_of>,
        <http://purl.obolibrary.org/obo/FMA_segmental_composition_of>,
        <http://purl.obolibrary.org/obo/FMA_segmental_supply_of>,
        <http://purl.obolibrary.org/obo/FMA_sends_output_to>,
        <http://purl.obolibrary.org/obo/FMA_superior_to>,
        <http://purl.obolibrary.org/obo/FMA_superolateral_to>,
        <http://purl.obolibrary.org/obo/FMA_superomedial_to>,
        <http://purl.obolibrary.org/obo/FMA_surrounded_by>,
        <http://purl.obolibrary.org/obo/FMA_surrounds>,
        <http://purl.obolibrary.org/obo/FMA_tributary_of>,
        <http://purl.obolibrary.org/obo/FMA_venous_drainage_of>,
        RO:0002219,
        RO:0002220,
        RO:0002221,
        <http://purl.obolibrary.org/obo/SO_has_origin>,
        <http://purl.obolibrary.org/obo/UBERON_anastomoses_with>,
        <http://purl.obolibrary.org/obo/UBERON_anteriorly_connected_to>,
        <http://purl.obolibrary.org/obo/UBERON_channel_for>,
        <http://purl.obolibrary.org/obo/UBERON_channels_from>,
        <http://purl.obolibrary.org/obo/UBERON_channels_into>,
        <http://purl.obolibrary.org/obo/UBERON_conduit_for>,
        <http://purl.obolibrary.org/obo/UBERON_distally_connected_to>,
        <http://purl.obolibrary.org/obo/UBERON_existence_starts_and_ends_during>,
        <http://purl.obolibrary.org/obo/UBERON_extends_fibers_into>,
        <http://purl.obolibrary.org/obo/UBERON_filtered_through>,
        <http://purl.obolibrary.org/obo/UBERON_in_central_side_of>,
        <http://purl.obolibrary.org/obo/UBERON_in_innermost_side_of>,
        <http://purl.obolibrary.org/obo/UBERON_in_outermost_side_of>,
        <http://purl.obolibrary.org/obo/UBERON_indirectly_supplies>,
        <http://purl.obolibrary.org/obo/UBERON_posteriorly_connected_to>,
        <http://purl.obolibrary.org/obo/UBERON_protects>,
        <http://purl.obolibrary.org/obo/UBERON_proximally_connected_to>,
        <http://purl.obolibrary.org/obo/UBERON_sexually_homologous_to>,
        UBERON_NONAMESPACE:distally_connected_to,
        UBERON_NONAMESPACE:subdivision_of,
        UBERON_CORE:anastomoses_with,
        UBERON_CORE:anteriorly_connected_to,
        UBERON_CORE:channel_for,
        UBERON_CORE:channels_from,
        UBERON_CORE:channels_into,
        UBERON_CORE:conduit_for,
        UBERON_CORE:distally_connected_to,
        UBERON_CORE:extends_fibers_into,
        UBERON_CORE:filtered_through,
        UBERON_CORE:indirectly_supplies,
        UBERON_CORE:posteriorly_connected_to,
        UBERON_CORE:proximally_connected_to,
        UBERON_CORE:synapsed_by,
        UBERON_CORE:transitively_anteriorly_connected_to,
        UBERON_CORE:transitively_connected_to,
        UBERON_CORE:transitively_distally_connected_to,
        UBERON_CORE:transitively_proximally_connected_to ;
    biolink:canonical_predicate "True" .

biolink:has_input a owl:ObjectProperty ;
    rdfs:label "has input" ;
    rdfs:domain biolink:BiologicalProcessOrActivity ;
    rdfs:range biolink:Occurrent ;
    rdfs:subPropertyOf biolink:has_participant ;
    owl:inverseOf biolink:is_input_of ;
    skos:closeMatch RO:0002352 ;
    skos:definition "holds between a process and a continuant, where the continuant is an input into the process" ;
    skos:exactMatch RO:0002233,
        SEMMEDDB:USES ;
    skos:narrowMatch LOINC:has_fragments_for_synonyms,
        LOINC:has_system,
        RO:0002590,
        RO:0004009,
        <http://purl.obolibrary.org/obo/SNOMED_has_finding_method>,
        <http://purl.obolibrary.org/obo/SNOMED_has_precondition>,
        <http://purl.obolibrary.org/obo/SNOMED_has_specimen_source_identity>,
        <http://purl.obolibrary.org/obo/SNOMED_has_specimen_substance>,
        <http://purl.obolibrary.org/obo/SNOMED_uses_access_device>,
        <http://purl.obolibrary.org/obo/SNOMED_uses_device>,
        <http://purl.obolibrary.org/obo/SNOMED_uses_energy>,
        <http://purl.obolibrary.org/obo/SNOMED_uses_substance>,
        PathWhiz:has_left_element ;
    biolink:canonical_predicate "True" ;
    biolink:opposite_of "has output" .

biolink:has_upstream_actor a owl:ObjectProperty ;
    rdfs:label "has upstream actor" ;
    rdfs:domain biolink:BiologicalProcess ;
    rdfs:range biolink:GeneOrGeneProduct ;
    rdfs:subPropertyOf biolink:related_to_at_instance_level ;
    owl:inverseOf biolink:acts_upstream_of .

biolink:object_context_qualifier a owl:ObjectProperty ;
    rdfs:label "object context qualifier" ;
    rdfs:domain biolink:Association ;
    rdfs:range linkml:String ;
    rdfs:subPropertyOf biolink:context_qualifier .

biolink:quantifier_qualifier a owl:ObjectProperty ;
    rdfs:label "quantifier qualifier" ;
    rdfs:domain biolink:Association ;
    rdfs:range biolink:OntologyClass ;
    rdfs:subPropertyOf biolink:association_slot ;
    skos:definition "A measurable quantity for the object of the association" ;
    skos:narrowMatch <http://identifiers.org/umls/measures>,
        LOINC:analyzes,
        LOINC:measured_by,
        LOINC:property_of,
        SEMMEDDB:MEASURES .

biolink:stage_qualifier a owl:ObjectProperty ;
    rdfs:label "stage qualifier" ;
    rdfs:domain biolink:Association ;
    rdfs:range biolink:LifeStage ;
    rdfs:subPropertyOf biolink:association_slot ;
    skos:definition "stage during which gene or protein expression of takes place." ;
    linkml:examples "Example(value='UBERON:0000069', description='larval stage')" .

biolink:subject_context_qualifier a owl:ObjectProperty ;
    rdfs:label "subject context qualifier" ;
    rdfs:domain biolink:Association ;
    rdfs:range linkml:String ;
    rdfs:subPropertyOf biolink:context_qualifier .

biolink:subject_form_or_variant_qualifier a owl:ObjectProperty ;
    rdfs:label "subject form or variant qualifier" ;
    rdfs:domain biolink:Association ;
    rdfs:range linkml:String ;
    rdfs:subPropertyOf biolink:form_or_variant_qualifier .

biolink:CategoryType a owl:Class ;
    rdfs:label "category type" ;
    rdfs:subClassOf linkml:Uriorcurie .

biolink:Dataset a owl:Class ;
    rdfs:label "dataset" ;
    rdfs:subClassOf biolink:InformationContentEntity ;
    skos:definition "an item that refers to a collection of data from a data source." ;
    skos:exactMatch IAO:0000100,
        <http://purl.org/dc/dcmitype/Dataset>,
        schema:dataset,
        dcid:Dataset .

biolink:GeneToEntityAssociationMixin a owl:Class ;
    rdfs:label "gene to entity association mixin" ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:onClass biolink:GeneOrGeneProduct ;
            owl:onProperty rdf:subject ;
            owl:qualifiedCardinality 1 ],
        linkml:mixin .

biolink:LifeStage a owl:Class ;
    rdfs:label "life stage" ;
    rdfs:subClassOf biolink:OrganismalEntity ;
    skos:definition "A stage of development or growth of an organism, including post-natal adult stages" ;
    skos:exactMatch <http://purl.obolibrary.org/obo/UBERON_0000105> ;
    skos:narrowMatch HsapDv:0000000 .

biolink:StudyResult a owl:Class ;
    rdfs:label "study result" ;
    rdfs:subClassOf biolink:InformationContentEntity ;
    skos:definition "A collection of data items from a study that are about a particular study subject or experimental unit (the  'focus' of the Result) - optionally with context/provenance metadata that may be relevant to the interpretation of this data as evidence." ;
    skos:editorialNote "The data/metadata included in a Study Result object are typically a subset of data from a larger study data set, that are selected by a curator because they may be useful as evidence for deriving knowledge about a specific focus of the study. The notion of a 'study' here is defined broadly to include any research activity at any scale that is aimed at generating knowledge or hypotheses. This may include a single assay or computational analyses, or a larger scale clinical trial or experimental research investigation." .

biolink:VariantToEntityAssociationMixin a owl:Class ;
    rdfs:label "variant to entity association mixin" ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:onClass biolink:SequenceVariant ;
            owl:onProperty rdf:subject ;
            owl:qualifiedCardinality 1 ],
        linkml:mixin .

biolink:contributor a owl:ObjectProperty ;
    rdfs:label "contributor" ;
    rdfs:domain biolink:Agent ;
    rdfs:range biolink:InformationContentEntity ;
    rdfs:subPropertyOf biolink:related_to_at_instance_level ;
    owl:inverseOf biolink:has_contributor ;
    skos:exactMatch dct:contributor ;
    skos:note "This is a grouping for predicates relating entities to their associated contributors realizing them" .

biolink:has_attribute a owl:ObjectProperty ;
    rdfs:label "has attribute" ;
    rdfs:domain biolink:Entity ;
    rdfs:range biolink:Attribute ;
    skos:closeMatch <http://purl.obolibrary.org/obo/OBI_0001927> ;
    skos:definition "connects any entity to an attribute" ;
    skos:exactMatch SIO:000008 ;
    skos:narrowMatch <http://identifiers.org/drugbank/category>,
        <http://identifiers.org/umls/has_structural_class>,
        <http://identifiers.org/umls/has_supported_concept_property>,
        <http://identifiers.org/umls/has_supported_concept_relationship>,
        <http://identifiers.org/umls/may_be_qualified_by>,
        LOINC:has_action_guidance,
        LOINC:has_adjustment,
        LOINC:has_aggregation_view,
        LOINC:has_approach_guidance,
        LOINC:has_divisor,
        LOINC:has_exam,
        LOINC:has_method,
        LOINC:has_modality_subtype,
        LOINC:has_object_guidance,
        LOINC:has_scale,
        LOINC:has_suffix,
        LOINC:has_time_aspect,
        LOINC:has_time_modifier,
        LOINC:has_timing_of,
        INO:0000154,
        <http://purl.obolibrary.org/obo/NCIT_R88>,
        <http://purl.obolibrary.org/obo/NCIT_eo_disease_has_property_or_attribute>,
        <http://purl.obolibrary.org/obo/NCIT_has_data_element>,
        <http://purl.obolibrary.org/obo/NCIT_has_pharmaceutical_administration_method>,
        <http://purl.obolibrary.org/obo/NCIT_has_pharmaceutical_basic_dose_form>,
        <http://purl.obolibrary.org/obo/NCIT_has_pharmaceutical_intended_site>,
        <http://purl.obolibrary.org/obo/NCIT_has_pharmaceutical_release_characteristics>,
        <http://purl.obolibrary.org/obo/NCIT_has_pharmaceutical_state_of_matter>,
        <http://purl.obolibrary.org/obo/NCIT_has_pharmaceutical_transformation>,
        <http://purl.obolibrary.org/obo/NCIT_is_qualified_by>,
        <http://purl.obolibrary.org/obo/NCIT_qualifier_applies_to>,
        <http://purl.obolibrary.org/obo/NCIT_role_has_domain>,
        <http://purl.obolibrary.org/obo/NCIT_role_has_range>,
        <http://purl.obolibrary.org/obo/OMIM_has_inheritance_type>,
        RO:0000053,
        RO:0000086,
        RO:0000087,
        <http://purl.obolibrary.org/obo/SNOMED_has_access>,
        <http://purl.obolibrary.org/obo/SNOMED_has_clinical_course>,
        <http://purl.obolibrary.org/obo/SNOMED_has_count_of_base_of_active_ingredient>,
        <http://purl.obolibrary.org/obo/SNOMED_has_dose_form_administration_method>,
        <http://purl.obolibrary.org/obo/SNOMED_has_dose_form_release_characteristic>,
        <http://purl.obolibrary.org/obo/SNOMED_has_dose_form_transformation>,
        <http://purl.obolibrary.org/obo/SNOMED_has_finding_context>,
        <http://purl.obolibrary.org/obo/SNOMED_has_finding_informer>,
        <http://purl.obolibrary.org/obo/SNOMED_has_inherent_attribute>,
        <http://purl.obolibrary.org/obo/SNOMED_has_intent>,
        <http://purl.obolibrary.org/obo/SNOMED_has_interpretation>,
        <http://purl.obolibrary.org/obo/SNOMED_has_laterality>,
        <http://purl.obolibrary.org/obo/SNOMED_has_measurement_method>,
        <http://purl.obolibrary.org/obo/SNOMED_has_method>,
        <http://purl.obolibrary.org/obo/SNOMED_has_priority>,
        <http://purl.obolibrary.org/obo/SNOMED_has_procedure_context>,
        <http://purl.obolibrary.org/obo/SNOMED_has_process_duration>,
        <http://purl.obolibrary.org/obo/SNOMED_has_property>,
        <http://purl.obolibrary.org/obo/SNOMED_has_revision_status>,
        <http://purl.obolibrary.org/obo/SNOMED_has_scale_type>,
        <http://purl.obolibrary.org/obo/SNOMED_has_severity>,
        <http://purl.obolibrary.org/obo/SNOMED_has_specimen>,
        <http://purl.obolibrary.org/obo/SNOMED_has_state_of_matter>,
        <http://purl.obolibrary.org/obo/SNOMED_has_subject_relationship_context>,
        <http://purl.obolibrary.org/obo/SNOMED_has_surgical_approach>,
        <http://purl.obolibrary.org/obo/SNOMED_has_technique>,
        <http://purl.obolibrary.org/obo/SNOMED_has_temporal_context>,
        <http://purl.obolibrary.org/obo/SNOMED_has_time_aspect>,
        <http://purl.obolibrary.org/obo/SNOMED_has_units>,
        OBAN:association_has_object_property,
        OBAN:association_has_subject_property,
        HANCESTRO:0301,
        HANCESTRO:0308,
        EFO:is_executed_in,
        orphanet:C016,
        orphanet:C017,
        CPT:has_possibly_included_panel_element .

biolink:has_contributor a owl:ObjectProperty ;
    rdfs:label "has contributor" ;
    rdfs:domain biolink:InformationContentEntity ;
    rdfs:range biolink:Agent ;
    rdfs:subPropertyOf biolink:related_to_at_instance_level ;
    owl:inverseOf biolink:contributor .

biolink:in_taxon a owl:ObjectProperty ;
    rdfs:label "in taxon" ;
    rdfs:domain biolink:ThingWithTaxon ;
    rdfs:range biolink:OrganismTaxon ;
    rdfs:subPropertyOf biolink:related_to_at_instance_level ;
    owl:inverseOf biolink:taxon_of ;
    skos:altLabel "gene found in organism",
        "gene product has organism source",
        "instance of",
        "is organism source of gene product",
        "organism has gene" ;
    skos:definition "connects an entity to its taxonomic classification. Only certain kinds of entities can be taxonomically classified; see 'thing with taxon'" ;
    skos:exactMatch RO:0002162,
        WIKIDATA_PROPERTY:P703 ;
    skos:narrowMatch RO:0002160 ;
    biolink:canonical_predicate "True" .

biolink:sequence_localization_attribute a owl:ObjectProperty ;
    rdfs:label "sequence localization attribute" ;
    rdfs:domain biolink:GenomicSequenceLocalization ;
    rdfs:range linkml:String ;
    rdfs:subPropertyOf biolink:association_slot ;
    skos:definition "An attribute that can be applied to a genome sequence localization edge. These edges connect a nucleic acid entity such as an exon to an entity such as a chromosome. Edge properties are used to ascribe specific positional information and other metadata to the localization. In pragmatic terms this can be thought of as columns in a GFF3 line." .

rdf:type a owl:ObjectProperty ;
    rdfs:label "type" ;
    rdfs:range linkml:String ;
    skos:exactMatch rdf:type,
        gff3:type,
        gpi:DB_Object_Type,
        AGRKB:soTermId .

rdfs:label a owl:ObjectProperty ;
    rdfs:label "name" ;
    rdfs:domain biolink:Entity ;
    rdfs:range biolink:LabelType ;
    skos:altLabel "display name",
        "label",
        "title" ;
    skos:definition "A human-readable name for an attribute or entity." ;
    skos:exactMatch rdfs:label,
        gff3:Name,
        gpi:DB_Object_Name ;
    skos:narrowMatch dct:title,
        WIKIDATA_PROPERTY:P1476 .

biolink:ChemicalMixture a owl:Class ;
    rdfs:label "chemical mixture" ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:maxQualifiedCardinality 1 ;
            owl:onClass linkml:String ;
            owl:onProperty biolink:highest_FDA_approval_status ],
        [ a owl:Restriction ;
            owl:maxQualifiedCardinality 1 ;
            owl:onClass biolink:ChemicalMixture ;
            owl:onProperty biolink:is_supplement ],
        [ a owl:Restriction ;
            owl:allValuesFrom biolink:DrugDeliveryEnum ;
            owl:onProperty biolink:routes_of_delivery ],
        [ a owl:Restriction ;
            owl:maxQualifiedCardinality 1 ;
            owl:onClass linkml:String ;
            owl:onProperty biolink:drug_regulatory_status_world_wide ],
        biolink:ChemicalEntity ;
    skos:closeMatch dcid:ChemicalCompound ;
    skos:definition "A chemical mixture is a chemical entity composed of two or more molecular entities." ;
    skos:narrowMatch <http://purl.obolibrary.org/obo/NCIT_C20401>,
        SNOMEDCT:49616005 .

biolink:ChemicalToEntityAssociationMixin a owl:Class ;
    rdfs:label "chemical to entity association mixin" ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:onClass biolink:ChemicalEntityOrGeneOrGeneProduct ;
            owl:onProperty rdf:subject ;
            owl:qualifiedCardinality 1 ],
        biolink:ChemicalEntityToEntityAssociationMixin,
        linkml:mixin ;
    skos:definition "An interaction between a chemical entity and another entity" .

biolink:Entity a owl:Class ;
    rdfs:label "entity" ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:allValuesFrom linkml:String ;
            owl:onProperty rdf:type ],
        [ a owl:Restriction ;
            owl:maxQualifiedCardinality 1 ;
            owl:onClass biolink:LabelType ;
            owl:onProperty rdfs:label ],
        [ a owl:Restriction ;
            owl:maxQualifiedCardinality 1 ;
            owl:onClass biolink:NarrativeText ;
            owl:onProperty dct:description ],
        [ a owl:Restriction ;
            owl:allValuesFrom biolink:Attribute ;
            owl:onProperty biolink:has_attribute ],
        [ a owl:Restriction ;
            owl:allValuesFrom biolink:CategoryType ;
            owl:onProperty biolink:category ],
        [ a owl:Restriction ;
            owl:onClass linkml:String ;
            owl:onProperty biolink:id ;
            owl:qualifiedCardinality 1 ],
        [ a owl:Restriction ;
            owl:maxQualifiedCardinality 1 ;
            owl:onClass biolink:IriType ;
            owl:onProperty biolink:iri ] ;
    skos:definition "Root Biolink Model class for all things and informational relationships, real or imagined." .

biolink:EntityToDiseaseOrPhenotypicFeatureAssociationMixin a owl:Class ;
    rdfs:label "entity to disease or phenotypic feature association mixin" ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:onClass biolink:DiseaseOrPhenotypicFeature ;
            owl:onProperty rdf:object ;
            owl:qualifiedCardinality 1 ],
        linkml:mixin .

biolink:GeneGroupingMixin a owl:Class ;
    rdfs:label "gene grouping mixin" ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:allValuesFrom biolink:Gene ;
            owl:onProperty biolink:has_gene_or_gene_product ],
        linkml:mixin ;
    skos:definition "any grouping of multiple genes or gene products" .

biolink:GeneOrGeneProductOrChemicalPartQualifierEnum a owl:Class ;
    rdfs:label "GeneOrGeneProductOrChemicalPartQualifierEnum" ;
    owl:unionOf ( <https://w3id.org/biolink/vocab/GeneOrGeneProductOrChemicalPartQualifierEnum#3_prime_utr> <https://w3id.org/biolink/vocab/GeneOrGeneProductOrChemicalPartQualifierEnum#5_prime_utr> <https://w3id.org/biolink/vocab/GeneOrGeneProductOrChemicalPartQualifierEnum#polya_tail> <https://w3id.org/biolink/vocab/GeneOrGeneProductOrChemicalPartQualifierEnum#promoter> <https://w3id.org/biolink/vocab/GeneOrGeneProductOrChemicalPartQualifierEnum#enhancer> <https://w3id.org/biolink/vocab/GeneOrGeneProductOrChemicalPartQualifierEnum#exon> <https://w3id.org/biolink/vocab/GeneOrGeneProductOrChemicalPartQualifierEnum#intron> ) ;
    linkml:permissible_values <https://w3id.org/biolink/vocab/GeneOrGeneProductOrChemicalPartQualifierEnum#3_prime_utr>,
        <https://w3id.org/biolink/vocab/GeneOrGeneProductOrChemicalPartQualifierEnum#5_prime_utr>,
        <https://w3id.org/biolink/vocab/GeneOrGeneProductOrChemicalPartQualifierEnum#enhancer>,
        <https://w3id.org/biolink/vocab/GeneOrGeneProductOrChemicalPartQualifierEnum#exon>,
        <https://w3id.org/biolink/vocab/GeneOrGeneProductOrChemicalPartQualifierEnum#intron>,
        <https://w3id.org/biolink/vocab/GeneOrGeneProductOrChemicalPartQualifierEnum#polya_tail>,
        <https://w3id.org/biolink/vocab/GeneOrGeneProductOrChemicalPartQualifierEnum#promoter> .

biolink:GeneProductMixin a owl:Class ;
    rdfs:label "gene product mixin" ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:allValuesFrom linkml:Uriorcurie ;
            owl:onProperty biolink:xref ],
        [ a owl:Restriction ;
            owl:allValuesFrom biolink:LabelType ;
            owl:onProperty biolink:synonym ],
        biolink:GeneOrGeneProduct,
        linkml:mixin ;
    skos:definition "The functional molecular product of a single gene locus. Gene products are either proteins or functional RNA molecules." ;
    skos:exactMatch <http://purl.obolibrary.org/obo/GENO_0000907>,
        <http://purl.obolibrary.org/obo/NCIT_C26548>,
        WIKIDATA:Q424689 .

biolink:ModelToDiseaseAssociationMixin a owl:Class ;
    rdfs:label "model to disease association mixin" ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:onClass biolink:PredicateType ;
            owl:onProperty rdf:predicate ;
            owl:qualifiedCardinality 1 ],
        [ a owl:Restriction ;
            owl:onClass biolink:NamedThing ;
            owl:onProperty rdf:subject ;
            owl:qualifiedCardinality 1 ],
        linkml:mixin ;
    skos:definition "This mixin is used for any association class for which the subject (source node) plays the role of a 'model', in that it recapitulates some features of the disease in a way that is useful for studying the disease outside a patient carrying the disease" .

biolink:PopulationOfIndividualOrganisms a owl:Class ;
    rdfs:label "population of individual organisms" ;
    rdfs:subClassOf biolink:OrganismalEntity,
        biolink:SubjectOfInvestigation ;
    skos:definition "A collection of individuals from the same taxonomic class distinguished by one or more characteristics.  Characteristics can include, but are not limited to, shared geographic location, genetics, phenotypes." ;
    skos:exactMatch STY:T098,
        <http://purl.obolibrary.org/obo/OBI_0000181>,
        <http://purl.obolibrary.org/obo/PCO_0000001>,
        SIO:001061 .

biolink:ThingWithTaxon a owl:Class ;
    rdfs:label "thing with taxon" ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:allValuesFrom biolink:OrganismTaxon ;
            owl:onProperty biolink:in_taxon ],
        linkml:mixin ;
    skos:definition "A mixin that can be used on any entity that can be taxonomically classified. This includes individual organisms; genes, their products and other molecular entities; body parts; biological processes" .

biolink:correlated_with a owl:ObjectProperty,
        owl:SymmetricProperty ;
    rdfs:label "correlated with" ;
    rdfs:domain biolink:NamedThing ;
    rdfs:range biolink:NamedThing ;
    rdfs:subPropertyOf biolink:associated_with ;
    skos:definition "A relationship that holds between two concepts represented by variables for which a statistical dependence is  demonstrated using a correlation analysis method." ;
    skos:editorialNote "These concepts may map exactly to the statistical variables, or represent related entities for which the  variables serve as proxies in an Association (e.g. diseases, chemical entities or processes)." ;
    skos:exactMatch <http://purl.obolibrary.org/obo/PATO_correlates_with>,
        RO:0002610 ;
    biolink:canonical_predicate "True" .

biolink:has_part a owl:ObjectProperty ;
    rdfs:label "has part" ;
    rdfs:domain biolink:NamedThing ;
    rdfs:range biolink:NamedThing ;
    rdfs:subPropertyOf biolink:overlaps ;
    owl:inverseOf biolink:part_of ;
    skos:broadMatch RXNORM:contains,
        <http://purl.obolibrary.org/obo/FMA_contains>,
        RO:0001019 ;
    skos:definition "holds between wholes and their parts (material entities or processes)" ;
    skos:exactMatch RXNORM:consists_of,
        RXNORM:has_part,
        <http://purl.obolibrary.org/obo/BFO_0000051>,
        <http://purl.obolibrary.org/obo/BFO_0000055>,
        RO:0001019,
        WIKIDATA_PROPERTY:P527 ;
    skos:narrowMatch <http://identifiers.org/meddra/has_member>,
        <http://identifiers.org/umls/has_component>,
        LOINC:has_component,
        LOINC:has_member,
        NDDF:has_ingredient,
        RXNORM:has_ingredient,
        <http://purl.obolibrary.org/obo/BFO_0000117>,
        <http://purl.obolibrary.org/obo/FMA_has_constitutional_part>,
        <http://purl.obolibrary.org/obo/FMA_has_member>,
        <http://purl.obolibrary.org/obo/FMA_has_part>,
        <http://purl.obolibrary.org/obo/FOODON_00001563>,
        <http://purl.obolibrary.org/obo/FOODON_00002420>,
        <http://purl.obolibrary.org/obo/MONDO_disease_has_major_feature>,
        <http://purl.obolibrary.org/obo/NCIT_R50>,
        <http://purl.obolibrary.org/obo/NCIT_complex_has_physical_part>,
        RO:0002104,
        RO:0002180,
        RO:0002351,
        RO:0002473,
        RO:0002524,
        RO:0002551,
        <http://purl.obolibrary.org/obo/SNOMED_has_component>,
        PathWhiz:has_element_in_bound,
        PathWhiz:has_protein_in_complex ;
    biolink:canonical_predicate "True" ;
    biolink:opposite_of "lacks part" .

biolink:part_of a owl:ObjectProperty ;
    rdfs:label "part of" ;
    rdfs:domain biolink:NamedThing ;
    rdfs:range biolink:NamedThing ;
    rdfs:subPropertyOf biolink:overlaps ;
    owl:inverseOf biolink:has_part ;
    skos:broadMatch RXNORM:contained_in,
        <http://purl.obolibrary.org/obo/FMA_contained_in>,
        RO:0001018 ;
    skos:definition "holds between parts and wholes (material entities or processes)" ;
    skos:exactMatch RXNORM:constitutes,
        RXNORM:part_of,
        <http://purl.obolibrary.org/obo/BFO_0000050>,
        <http://purl.obolibrary.org/obo/FMA_part_of>,
        SEMMEDDB:PART_OF,
        WIKIDATA_PROPERTY:P361 ;
    skos:narrowMatch <http://identifiers.org/drugbank/component_of>,
        <http://identifiers.org/meddra/member_of>,
        <http://identifiers.org/umls/component_of>,
        <http://identifiers.org/umls/has_owning_affiliate>,
        <http://identifiers.org/umls/owning_subsection_of>,
        LOINC:component_of,
        LOINC:has_supersystem,
        LOINC:member_of,
        LOINC:multipart_of,
        NDDF:ingredient_of,
        RXNORM:ingredient_of,
        RXNORM:ingredients_of,
        RXNORM:precise_ingredient_of,
        <http://purl.obolibrary.org/obo/BSPO_0001106>,
        <http://purl.obolibrary.org/obo/BSPO_0001108>,
        <http://purl.obolibrary.org/obo/BSPO_0001113>,
        <http://purl.obolibrary.org/obo/BSPO_0001115>,
        <http://purl.obolibrary.org/obo/CHEBI_is_substituent_group_from>,
        <http://purl.obolibrary.org/obo/FMA_constitutional_part_of>,
        <http://purl.obolibrary.org/obo/FMA_member_of>,
        <http://purl.obolibrary.org/obo/FMA_regional_part_of>,
        <http://purl.obolibrary.org/obo/FMA_related_developmental_entity_of>,
        <http://purl.obolibrary.org/obo/MONDO_part_of_progression_of_disease>,
        <http://purl.obolibrary.org/obo/NCIT_R27>,
        <http://purl.obolibrary.org/obo/NCIT_R82>,
        <http://purl.obolibrary.org/obo/NCIT_is_component_of_chemotherapy_regimen>,
        RO:0002007,
        RO:0002350,
        RO:0002376,
        RO:0002380,
        RO:0002571,
        RO:0002572,
        RO:0002576,
        <http://purl.obolibrary.org/obo/SNOMED_active_ingredient_of>,
        <http://purl.obolibrary.org/obo/SNOMED_basis_of_strength_substance_of>,
        <http://purl.obolibrary.org/obo/SNOMED_component_of>,
        <http://purl.obolibrary.org/obo/SNOMED_direct_substance_of>,
        <http://purl.obolibrary.org/obo/SNOMED_during>,
        <http://purl.obolibrary.org/obo/SNOMED_focus_of>,
        <http://purl.obolibrary.org/obo/SNOMED_has_dependent>,
        <http://purl.obolibrary.org/obo/SNOMED_part_anatomy_structure_of>,
        <http://purl.obolibrary.org/obo/SNOMED_precise_active_ingredient_of>,
        <http://purl.obolibrary.org/obo/UBERON_subdivision_of>,
        UBERON_CORE:layer_part_of,
        UBERON_CORE:subdivision_of,
        UBERON_CORE:trunk_part_of,
        CPT:panel_element_of,
        CPT:panel_element_of_possibly_included,
        VANDF:ingredient_of .

biolink:related_to a owl:ObjectProperty,
        owl:SymmetricProperty ;
    rdfs:label "related to" ;
    rdfs:domain biolink:NamedThing ;
    rdfs:range biolink:NamedThing ;
    skos:broadMatch owl:topObjectProperty ;
    skos:definition "A relationship that is asserted between two named things" ;
    skos:exactMatch <http://identifiers.org/umls/related_to>,
        skos:relatedMatch ;
    skos:narrowMatch MESH:RO,
        MESH:has_mapping_qualifier,
        MESH:mapped_to,
        <http://identifiers.org/hmdb/disease>,
        <http://identifiers.org/hmdb/has_protein_association>,
        <http://identifiers.org/umls/RO>,
        <http://identifiers.org/umls/RQ>,
        <http://identifiers.org/umls/class_code_classified_by>,
        <http://identifiers.org/umls/exhibited_by>,
        <http://identifiers.org/umls/has_context_binding>,
        <http://identifiers.org/umls/has_form>,
        <http://identifiers.org/umls/has_mapping_qualifier>,
        <http://identifiers.org/umls/larger_than>,
        <http://identifiers.org/umls/mapped_to>,
        <http://identifiers.org/umls/owning_section_of>,
        LOINC:has_answer,
        LOINC:has_challenge,
        LOINC:has_evaluation,
        LOINC:mapped_to,
        LOINC:mth_has_expanded_form,
        HCPCS:mapped_to,
        RXNORM:has_form,
        RXNORM:reformulated_to,
        <http://purl.obolibrary.org/obo/BFO_0000054>,
        <http://purl.obolibrary.org/obo/BTO_related_to>,
        <http://purl.obolibrary.org/obo/CHEBI_is_conjugate_acid_of>,
        <http://purl.obolibrary.org/obo/CHEBI_is_conjugate_base_of>,
        <http://purl.obolibrary.org/obo/FMA_connected_to>,
        <http://purl.obolibrary.org/obo/FMA_continuous_with>,
        <http://purl.obolibrary.org/obo/FMA_homonym_of>,
        <http://purl.obolibrary.org/obo/FMA_related_developmental_entity_of>,
        GOREL:0002005,
        GOREL:0012006,
        IAO:0000136,
        <http://purl.obolibrary.org/obo/MONDO_disease_shares_features_of>,
        <http://purl.obolibrary.org/obo/NCIT_disease_may_have_associated_disease>,
        <http://purl.obolibrary.org/obo/NCIT_human_disease_maps_to_eo_disease>,
        <http://purl.obolibrary.org/obo/NCIT_is_abnormal_cell_of_disease>,
        <http://purl.obolibrary.org/obo/NCIT_is_related_to_endogenous_product>,
        <http://purl.obolibrary.org/obo/PATO_reciprocal_of>,
        RO:0000052,
        RO:0000053,
        RO:0002001,
        RO:0002002,
        RO:0002003,
        RO:0002008,
        RO:0002084,
        RO:0002092,
        RO:0002093,
        RO:0002134,
        RO:0002150,
        RO:0002159,
        RO:0002176,
        RO:0002177,
        RO:0002178,
        RO:0002179,
        RO:0002314,
        RO:0002322,
        RO:0002328,
        RO:0002332,
        RO:0002338,
        RO:0002339,
        RO:0002341,
        RO:0002342,
        RO:0002344,
        RO:0002348,
        RO:0002349,
        RO:0002356,
        RO:0002371,
        RO:0002372,
        RO:0002373,
        RO:0002374,
        RO:0002385,
        RO:0002387,
        RO:0002451,
        RO:0002494,
        RO:0002495,
        RO:0002568,
        RO:0002573,
        RO:0004026,
        RO:0004027,
        RO:0009001,
        RO:0009004,
        <http://purl.obolibrary.org/obo/SNOMED_has_associated_morphology>,
        <http://purl.obolibrary.org/obo/SNOMED_has_associated_procedure>,
        <http://purl.obolibrary.org/obo/SNOMED_has_direct_morphology>,
        <http://purl.obolibrary.org/obo/SNOMED_has_disposition>,
        <http://purl.obolibrary.org/obo/SNOMED_has_indirect_morphology>,
        <http://purl.obolibrary.org/obo/SNOMED_has_modification>,
        <http://purl.obolibrary.org/obo/SNOMED_has_procedure_morphology>,
        <http://purl.obolibrary.org/obo/SNOMED_has_specimen_source_morphology>,
        <http://purl.obolibrary.org/obo/SNOMED_inheres_in>,
        <http://purl.obolibrary.org/obo/SNOMED_is_interpreted_by>,
        <http://purl.obolibrary.org/obo/SNOMED_relative_to_part_of>,
        <http://purl.obolibrary.org/obo/UBERON_synapsed_by>,
        UBERON_NONAMESPACE:connected_to,
        UBERON_NONAMESPACE:innervated_by,
        NBO-PROPERTY:is_about,
        UBERON_CORE:protects,
        EFO:0006351,
        SEMMEDDB:ASSOCIATED_WITH,
        SEMMEDDB:compared_with,
        SEMMEDDB:higher_than,
        SEMMEDDB:lower_than,
        CPT:has_add_on_code,
        CPT:mapped_to ;
    biolink:canonical_predicate "True" .

biolink:supporting_study_metadata a owl:ObjectProperty ;
    rdfs:label "supporting study metadata" ;
    rdfs:domain biolink:Association ;
    rdfs:range linkml:String ;
    rdfs:subPropertyOf biolink:association_slot ;
    skos:definition "Information about a study used to generate information used as evidence to support the knowledge expressed in an  Association. In practice, data creators should use one of the more specific subtypes of this property." .

biolink:DirectionQualifierEnum a owl:Class ;
    rdfs:label "DirectionQualifierEnum" ;
    owl:unionOf ( <https://w3id.org/biolink/vocab/DirectionQualifierEnum#increased> <https://w3id.org/biolink/vocab/DirectionQualifierEnum#upregulated> <https://w3id.org/biolink/vocab/DirectionQualifierEnum#decreased> <https://w3id.org/biolink/vocab/DirectionQualifierEnum#downregulated> ) ;
    linkml:permissible_values <https://w3id.org/biolink/vocab/DirectionQualifierEnum#decreased>,
        <https://w3id.org/biolink/vocab/DirectionQualifierEnum#downregulated>,
        <https://w3id.org/biolink/vocab/DirectionQualifierEnum#increased>,
        <https://w3id.org/biolink/vocab/DirectionQualifierEnum#upregulated> .

biolink:EntityToPhenotypicFeatureAssociationMixin a owl:Class ;
    rdfs:label "entity to phenotypic feature association mixin" ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:maxQualifiedCardinality 1 ;
            owl:onClass linkml:Integer ;
            owl:onProperty biolink:has_total ],
        [ a owl:Restriction ;
            owl:maxQualifiedCardinality 1 ;
            owl:onClass biolink:BiologicalSex ;
            owl:onProperty biolink:sex_qualifier ],
        [ a owl:Restriction ;
            owl:maxQualifiedCardinality 1 ;
            owl:onClass linkml:Integer ;
            owl:onProperty biolink:has_count ],
        [ a owl:Restriction ;
            owl:onClass biolink:PhenotypicFeature ;
            owl:onProperty rdf:object ;
            owl:qualifiedCardinality 1 ],
        [ a owl:Restriction ;
            owl:maxQualifiedCardinality 1 ;
            owl:onClass linkml:Double ;
            owl:onProperty biolink:has_quotient ],
        [ a owl:Restriction ;
            owl:maxQualifiedCardinality 1 ;
            owl:onClass linkml:Double ;
            owl:onProperty biolink:has_percentage ],
        biolink:EntityToFeatureOrDiseaseQualifiersMixin,
        biolink:FrequencyQuantifier,
        linkml:mixin .

biolink:Genotype a owl:Class ;
    rdfs:label "genotype" ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:maxQualifiedCardinality 1 ;
            owl:onClass biolink:BiologicalSequence ;
            owl:onProperty biolink:has_biological_sequence ],
        [ a owl:Restriction ;
            owl:maxQualifiedCardinality 1 ;
            owl:onClass biolink:Zygosity ;
            owl:onProperty biolink:has_zygosity ],
        biolink:BiologicalEntity,
        biolink:GenomicEntity,
        biolink:OntologyClass,
        biolink:PhysicalEssence ;
    skos:definition "An information content entity that describes a genome by specifying the total variation in genomic sequence and/or gene expression, relative to some established background" ;
    skos:exactMatch <http://purl.obolibrary.org/obo/GENO_0000536>,
        SIO:001079 ;
    skos:note "Consider renaming as genotypic entity" .

biolink:MacromolecularMachineMixin a owl:Class ;
    rdfs:label "macromolecular machine mixin" ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:maxQualifiedCardinality 1 ;
            owl:onClass biolink:SymbolType ;
            owl:onProperty rdfs:label ],
        linkml:mixin ;
    skos:definition "A union of gene locus, gene product, and macromolecular complex. These are the basic units of function in a cell. They either carry out individual biological activities, or they encode molecules which do this." .

biolink:PhenotypicFeature a owl:Class ;
    rdfs:label "phenotypic feature" ;
    rdfs:subClassOf biolink:DiseaseOrPhenotypicFeature ;
    skos:altLabel "endophenotype",
        "phenotype",
        "sign",
        "symptom",
        "trait" ;
    skos:broadMatch <http://purl.obolibrary.org/obo/BFO_0000019>,
        <http://purl.obolibrary.org/obo/PATO_0000001> ;
    skos:definition "A combination of entity and quality that makes up a phenotyping statement. An observable characteristic of an  individual resulting from the interaction of its genotype with its molecular and physical environment." ;
    skos:exactMatch MESH:D010641,
        <http://identifiers.org/umls/C4021819>,
        <http://purl.obolibrary.org/obo/NCIT_C16977>,
        <http://purl.obolibrary.org/obo/UPHENO_0001001>,
        SIO:010056,
        SNOMEDCT:8116006,
        WIKIDATA:Q104053 ;
    skos:narrowMatch STY:T184,
        <http://purl.obolibrary.org/obo/APO_0000017>,
        <http://purl.obolibrary.org/obo/FBcv_0001347>,
        FYPO:0000001,
        <http://purl.obolibrary.org/obo/HP_0000118>,
        <http://purl.obolibrary.org/obo/MP_0000001>,
        <http://purl.obolibrary.org/obo/TO_0000387>,
        <http://purl.obolibrary.org/obo/WBPhenotype_0000886>,
        XPO:00000000,
        <http://purl.obolibrary.org/obo/ZP_00000000>,
        WIKIDATA:Q169872,
        WIKIDATA:Q25203551 ;
    linkml:examples "Example(value='MP:0001262', description='decreased body weight')" .

biolink:PhysicalEssenceOrOccurrent a owl:Class ;
    rdfs:label "physical essence or occurrent" ;
    rdfs:subClassOf linkml:mixin ;
    skos:definition "Either a physical or processual entity." .

biolink:Transcript a owl:Class ;
    rdfs:label "transcript" ;
    rdfs:subClassOf biolink:NucleicAcidEntity ;
    skos:definition "An RNA synthesized on a DNA or RNA template by an RNA polymerase." ;
    skos:exactMatch <http://purl.obolibrary.org/obo/SO_0000673>,
        SIO:010450,
        dcid:RNATranscript,
        WIKIDATA:Q7243183 .

biolink:associated_with a owl:ObjectProperty,
        owl:SymmetricProperty ;
    rdfs:label "associated with" ;
    rdfs:domain biolink:NamedThing ;
    rdfs:range biolink:NamedThing ;
    rdfs:subPropertyOf biolink:related_to_at_instance_level ;
    skos:definition "Expresses a relationship between two named things where the relationship is typically generated statistically (though not in all cases), and is weaker than its child, 'correlated with', but stronger than its parent, 'related to'. This relationship holds between two concepts represented by variables for which a statistical  dependence is demonstrated.  E.g. the statement “Atrial Fibrillation (Afib) is associated with Myocardial  Infarction (MI)” asserts that having Afib is not statistically independent from whether a patient  will also have MI. Note that in Translator associations, the subject and object concepts may map exactly to  the statistical variables, or represent related entities for which the variables serve as proxies in an  Association (e.g. diseases, chemical entities or processes)." ;
    skos:narrowMatch RO:0004029,
        SNOMEDCT:47429007 ;
    biolink:canonical_predicate "True" .

biolink:has_gene_or_gene_product a owl:ObjectProperty ;
    rdfs:label "has gene or gene product" ;
    rdfs:domain biolink:NamedThing ;
    rdfs:range biolink:Gene ;
    rdfs:subPropertyOf biolink:node_property ;
    skos:definition "connects an entity with one or more gene or gene products" .

biolink:has_participant a owl:ObjectProperty ;
    rdfs:label "has participant" ;
    rdfs:domain biolink:BiologicalProcessOrActivity ;
    rdfs:range biolink:Occurrent ;
    rdfs:subPropertyOf biolink:related_to_at_instance_level ;
    owl:inverseOf biolink:participates_in ;
    skos:closeMatch WIKIDATA_PROPERTY:P2283 ;
    skos:definition "holds between a process and a continuant, where the continuant is somehow involved in the process" ;
    skos:exactMatch RO:0000057,
        RO:has_participant ;
    skos:narrowMatch LOINC:has_subject,
        <http://purl.obolibrary.org/obo/BFO_0000167>,
        <http://purl.obolibrary.org/obo/NCIT_process_involves_gene>,
        <http://purl.obolibrary.org/obo/OBI_0000293>,
        RO:0004007,
        RO:0004020,
        RO:0004021,
        <http://purl.obolibrary.org/obo/SNOMED_has_indirect_device>,
        <http://purl.obolibrary.org/obo/SNOMED_has_procedure_device>,
        <http://purl.obolibrary.org/obo/SNOMED_has_recipient_category>,
        NBO-PROPERTY:has_participant,
        PathWhiz:has_bound,
        PathWhiz:has_compound,
        PathWhiz:has_element_collection,
        PathWhiz:has_enzyme,
        PathWhiz:has_nucleic_acid,
        PathWhiz:has_protein,
        PathWhiz:has_reaction ;
    biolink:canonical_predicate "True" .

biolink:participates_in a owl:ObjectProperty ;
    rdfs:label "participates in" ;
    rdfs:domain biolink:Occurrent ;
    rdfs:range biolink:BiologicalProcessOrActivity ;
    rdfs:subPropertyOf biolink:related_to_at_instance_level ;
    owl:inverseOf biolink:has_participant ;
    skos:definition "holds between a continuant and a process, where the continuant is somehow involved in the process" ;
    skos:exactMatch <http://purl.obolibrary.org/obo/BFO_0000056>,
        RO:0000056 ;
    skos:narrowMatch <http://identifiers.org/drugbank/pathway>,
        <http://identifiers.org/hmdb/in_pathway>,
        LOINC:is_given_pharmaceutical_substance_for,
        <http://purl.obolibrary.org/obo/NCIT_R130>,
        <http://purl.obolibrary.org/obo/NCIT_R131>,
        <http://purl.obolibrary.org/obo/NCIT_R37>,
        <http://purl.obolibrary.org/obo/NCIT_R51>,
        <http://purl.obolibrary.org/obo/NCIT_R53>,
        <http://purl.obolibrary.org/obo/OBI_0000295>,
        RO:0002216,
        RO:0002505,
        RO:0002565,
        <http://purl.obolibrary.org/obo/SNOMED_has_direct_device> .

biolink:InformationResource a owl:Class ;
    rdfs:label "information resource" ;
    rdfs:subClassOf biolink:InformationContentEntity ;
    skos:altLabel "knowledgebase" ;
    skos:definition "A database or knowledgebase and its supporting ecosystem of interfaces  and services that deliver content to consumers (e.g. web portals, APIs,  query endpoints, streaming services, data downloads, etc.). A single Information Resource by this definition may span many different datasets or databases, and include many access endpoints and user interfaces. Information Resources include project-specific resources such as a Translator Knowledge Provider, and community knowledgebases like ChemBL, OMIM, or DGIdb." .

biolink:affected_by a owl:ObjectProperty ;
    rdfs:label "affected by" ;
    rdfs:domain biolink:NamedThing ;
    rdfs:range biolink:NamedThing ;
    rdfs:subPropertyOf biolink:related_to_at_instance_level ;
    owl:inverseOf biolink:affects ;
    skos:definition "describes an entity of which the state or quality is affected by another existing entity." .

biolink:affects a owl:ObjectProperty ;
    rdfs:label "affects" ;
    rdfs:domain biolink:NamedThing ;
    rdfs:range biolink:NamedThing ;
    rdfs:subPropertyOf biolink:related_to_at_instance_level ;
    owl:inverseOf biolink:affected_by ;
    skos:definition "describes an entity that has a direct affect on the state or quality of another existing entity. Use of the 'affects' predicate implies that the affected entity already exists, unlike predicates such as 'affects risk for' and 'prevents, where the outcome is something that may or may not come to be." ;
    skos:exactMatch SEMMEDDB:AFFECTS,
        DGIdb:affects ;
    skos:narrowMatch CTD:inferred,
        CTD:prediction_hypothesis,
        GOREL:0001006,
        <http://purl.obolibrary.org/obo/NCIT_R100>,
        <http://purl.obolibrary.org/obo/NCIT_R101>,
        <http://purl.obolibrary.org/obo/NCIT_R102>,
        <http://purl.obolibrary.org/obo/NCIT_R113>,
        <http://purl.obolibrary.org/obo/NCIT_R124>,
        <http://purl.obolibrary.org/obo/NCIT_R133>,
        <http://purl.obolibrary.org/obo/NCIT_R146>,
        <http://purl.obolibrary.org/obo/NCIT_R150>,
        <http://purl.obolibrary.org/obo/NCIT_R158>,
        <http://purl.obolibrary.org/obo/NCIT_R160>,
        <http://purl.obolibrary.org/obo/NCIT_R173>,
        <http://purl.obolibrary.org/obo/NCIT_R23>,
        <http://purl.obolibrary.org/obo/NCIT_R25>,
        <http://purl.obolibrary.org/obo/NCIT_R30>,
        <http://purl.obolibrary.org/obo/NCIT_R72>,
        <http://purl.obolibrary.org/obo/NCIT_gene_mapped_to_disease>,
        RO:0002263,
        RO:0002264,
        RO:0002343,
        RO:0002355,
        RO:0002591,
        RO:0002592,
        RO:0012003,
        <http://purl.obolibrary.org/obo/SNOMED_has_pathological_process>,
        <http://purl.obolibrary.org/obo/UPHENO_0000001>,
        UBERGRAPH:is_decrease_of,
        UBERGRAPH:is_increase_of,
        SEMMEDDB:ADMINISTERED_TO ;
    skos:relatedMatch <http://identifiers.org/drugbank/pathway> ;
    biolink:canonical_predicate "True" .

biolink:has_sequence_variant a owl:ObjectProperty ;
    rdfs:label "has sequence variant" ;
    rdfs:domain biolink:GenomicEntity ;
    rdfs:range biolink:SequenceVariant ;
    rdfs:subPropertyOf biolink:related_to_at_instance_level ;
    owl:inverseOf biolink:is_sequence_variant_of .

biolink:is_sequence_variant_of a owl:ObjectProperty ;
    rdfs:label "is sequence variant of" ;
    rdfs:domain biolink:SequenceVariant ;
    rdfs:range biolink:GenomicEntity ;
    rdfs:subPropertyOf biolink:related_to_at_instance_level ;
    owl:inverseOf biolink:has_sequence_variant ;
    skos:altLabel "allelic variant of",
        "gene product sequence variation encoded by gene mutant",
        "gene product variant of gene product" ;
    skos:definition "holds between a sequence variant and a nucleic acid entity" ;
    skos:narrowMatch WIKIDATA:P3433 ;
    biolink:canonical_predicate "True" .

biolink:related_to_at_concept_level a owl:ObjectProperty,
        owl:SymmetricProperty ;
    rdfs:label "related to at concept level" ;
    rdfs:domain biolink:NamedThing ;
    rdfs:range biolink:NamedThing ;
    rdfs:subPropertyOf biolink:related_to ;
    skos:definition "Represents a relationship held between terminology components that describe the conceptual model of a domain." ;
    biolink:canonical_predicate "True" .

biolink:sex_qualifier a owl:ObjectProperty ;
    rdfs:label "sex qualifier" ;
    rdfs:domain biolink:Association ;
    rdfs:range biolink:BiologicalSex ;
    rdfs:subPropertyOf biolink:qualifier ;
    skos:definition "a qualifier used in a phenotypic association to state whether the association is specific to a particular sex." .

biolink:Disease a owl:Class ;
    rdfs:label "disease" ;
    rdfs:subClassOf biolink:DiseaseOrPhenotypicFeature ;
    skos:altLabel "condition",
        "disorder",
        "medical condition" ;
    skos:definition "A disorder of structure or function, especially one that produces specific  signs, phenotypes or symptoms or that affects a specific location and is not simply a  direct result of physical injury.  A disposition to undergo pathological processes that exists in an  organism because of one or more disorders in that organism." ;
    skos:exactMatch STY:T047,
        <http://purl.obolibrary.org/obo/DOID_4>,
        <http://purl.obolibrary.org/obo/MONDO_0000001>,
        <http://purl.obolibrary.org/obo/NCIT_C2991>,
        SIO:010299,
        dcid:Disease,
        UMLSSG:DISO,
        WIKIDATA:Q12136 ;
    skos:narrowMatch STY:T019,
        STY:T020,
        STY:T048,
        STY:T049,
        STY:T190,
        STY:T191,
        <http://purl.obolibrary.org/obo/MONDO_0042489> .

biolink:Drug a owl:Class ;
    rdfs:label "drug" ;
    rdfs:subClassOf biolink:ChemicalOrDrugOrTreatment,
        biolink:MolecularMixture,
        biolink:OntologyClass ;
    skos:broadMatch STY:T121 ;
    skos:definition "A substance intended for use in the diagnosis, cure, mitigation, treatment, or prevention of disease" ;
    skos:exactMatch STY:T200,
        <http://purl.obolibrary.org/obo/CHEBI_23888>,
        dcid:Drug,
        WIKIDATA:Q12140 ;
    skos:narrowMatch STY:T195 ;
    skos:note "The CHEBI ID represents a role rather than a substance" .

biolink:EntityToDiseaseAssociationMixin a owl:Class ;
    rdfs:label "entity to disease association mixin" ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:onClass biolink:Disease ;
            owl:onProperty rdf:object ;
            owl:qualifiedCardinality 1 ],
        biolink:EntityToFeatureOrDiseaseQualifiersMixin,
        linkml:mixin ;
    skos:definition "mixin class for any association whose object (target node) is a disease" .

biolink:GenomicSequenceLocalization a owl:Class ;
    rdfs:label "genomic sequence localization" ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:maxQualifiedCardinality 1 ;
            owl:onClass linkml:Integer ;
            owl:onProperty biolink:start_interbase_coordinate ],
        [ a owl:Restriction ;
            owl:maxQualifiedCardinality 1 ;
            owl:onClass biolink:StrandEnum ;
            owl:onProperty biolink:genome_build ],
        [ a owl:Restriction ;
            owl:maxQualifiedCardinality 1 ;
            owl:onClass biolink:PhaseEnum ;
            owl:onProperty biolink:phase ],
        [ a owl:Restriction ;
            owl:onClass biolink:PredicateType ;
            owl:onProperty rdf:predicate ;
            owl:qualifiedCardinality 1 ],
        [ a owl:Restriction ;
            owl:maxQualifiedCardinality 1 ;
            owl:onClass linkml:Integer ;
            owl:onProperty biolink:end_interbase_coordinate ],
        [ a owl:Restriction ;
            owl:onClass biolink:NucleicAcidEntity ;
            owl:onProperty rdf:subject ;
            owl:qualifiedCardinality 1 ],
        [ a owl:Restriction ;
            owl:onClass biolink:NucleicAcidEntity ;
            owl:onProperty rdf:object ;
            owl:qualifiedCardinality 1 ],
        [ a owl:Restriction ;
            owl:maxQualifiedCardinality 1 ;
            owl:onClass biolink:StrandEnum ;
            owl:onProperty biolink:strand ],
        biolink:SequenceAssociation ;
    skos:broadMatch dcid:Chromosome ;
    skos:definition "A relationship between a sequence feature and a nucleic acid entity it is localized to. The reference entity may be a chromosome, chromosome region or information entity such as a contig." ;
    skos:exactMatch dcid:GenomeAnnotation .

biolink:OrganismalEntity a owl:Class ;
    rdfs:label "organismal entity" ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:allValuesFrom biolink:Attribute ;
            owl:onProperty biolink:has_attribute ],
        biolink:BiologicalEntity,
        biolink:SubjectOfInvestigation ;
    skos:definition "A named entity that is either a part of an organism, a whole organism, population or clade of organisms, excluding chemical entities" ;
    skos:exactMatch <http://purl.obolibrary.org/obo/CARO_0001010>,
        UMLSSG:LIVB,
        WIKIDATA:Q7239 .

biolink:id a owl:ObjectProperty ;
    rdfs:label "id" ;
    rdfs:range linkml:String ;
    skos:definition "A unique identifier for an entity. Must be either a CURIE shorthand for a URI or a complete URI" ;
    skos:exactMatch gff3:ID,
        gpi:DB_Object_ID,
        AGRKB:primaryId .

biolink:Outcome a owl:Class ;
    rdfs:label "outcome" ;
    rdfs:subClassOf linkml:mixin ;
    skos:definition "An entity that has the role of being the consequence of an exposure event. This is an abstract mixin grouping of various categories of possible biological or non-biological (e.g. clinical) outcomes." .

biolink:SubjectOfInvestigation a owl:Class ;
    rdfs:label "subject of investigation" ;
    rdfs:subClassOf linkml:mixin ;
    skos:definition "An entity that has the role of being studied in an investigation, study, or experiment" .

biolink:has_count a owl:ObjectProperty ;
    rdfs:label "has count" ;
    rdfs:domain biolink:NamedThing ;
    rdfs:range linkml:Integer ;
    rdfs:subPropertyOf biolink:aggregate_statistic ;
    skos:definition "number of things with a particular property" ;
    skos:exactMatch LOINC:has_count .

biolink:has_percentage a owl:ObjectProperty ;
    rdfs:label "has percentage" ;
    rdfs:domain biolink:NamedThing ;
    rdfs:range linkml:Double ;
    rdfs:subPropertyOf biolink:aggregate_statistic ;
    skos:definition "equivalent to has quotient multiplied by 100" .

biolink:has_quotient a owl:ObjectProperty ;
    rdfs:label "has quotient" ;
    rdfs:domain biolink:NamedThing ;
    rdfs:range linkml:Double ;
    rdfs:subPropertyOf biolink:aggregate_statistic .

biolink:has_total a owl:ObjectProperty ;
    rdfs:label "has total" ;
    rdfs:domain biolink:NamedThing ;
    rdfs:range linkml:Integer ;
    rdfs:subPropertyOf biolink:aggregate_statistic ;
    skos:definition "total number of things in a particular reference set" .

biolink:synonym a owl:ObjectProperty ;
    rdfs:label "synonym" ;
    rdfs:domain biolink:NamedThing ;
    rdfs:range biolink:LabelType ;
    rdfs:subPropertyOf biolink:node_property ;
    skos:altLabel "alias" ;
    skos:definition "Alternate human-readable names for a thing" ;
    skos:narrowMatch RXNORM:has_tradename,
        IAO:0000136,
        HANCESTRO:0330,
        skos:altLabel,
        gff3:Alias,
        gpi:DB_Object_Synonyms,
        AGRKB:synonyms .

biolink:BiologicalSex a owl:Class ;
    rdfs:label "biological sex" ;
    rdfs:subClassOf biolink:Attribute ;
    skos:exactMatch <http://purl.obolibrary.org/obo/PATO_0000047> .

biolink:MolecularActivity a owl:Class ;
    rdfs:label "molecular activity" ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:allValuesFrom biolink:MolecularEntity ;
            owl:onProperty biolink:has_output ],
        [ a owl:Restriction ;
            owl:allValuesFrom biolink:MolecularEntity ;
            owl:onProperty biolink:has_input ],
        [ a owl:Restriction ;
            owl:allValuesFrom biolink:MacromolecularMachineMixin ;
            owl:onProperty biolink:enabled_by ],
        biolink:BiologicalProcessOrActivity,
        biolink:Occurrent,
        biolink:OntologyClass ;
    skos:altLabel "molecular event",
        "molecular function",
        "reaction" ;
    skos:definition "An execution of a molecular function carried out by a gene product or macromolecular complex." ;
    skos:exactMatch STY:T044,
        <http://purl.obolibrary.org/obo/GO_0003674> .

biolink:PhysicalEssence a owl:Class ;
    rdfs:label "physical essence" ;
    rdfs:subClassOf biolink:PhysicalEssenceOrOccurrent,
        linkml:mixin ;
    skos:definition "Semantic mixin concept.  Pertains to entities that have physical properties such as mass, volume, or charge." .

biolink:has_biological_sequence a owl:ObjectProperty ;
    rdfs:label "has biological sequence" ;
    rdfs:domain biolink:NamedThing ;
    rdfs:range biolink:BiologicalSequence ;
    rdfs:subPropertyOf biolink:node_property ;
    skos:definition "connects a genomic feature to its sequence" .

biolink:Agent a owl:Class ;
    rdfs:label "agent" ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:maxQualifiedCardinality 1 ;
            owl:onClass biolink:LabelType ;
            owl:onProperty rdfs:label ],
        [ a owl:Restriction ;
            owl:maxQualifiedCardinality 1 ;
            owl:onClass linkml:String ;
            owl:onProperty biolink:address ],
        [ a owl:Restriction ;
            owl:onClass linkml:String ;
            owl:onProperty biolink:id ;
            owl:qualifiedCardinality 1 ],
        [ a owl:Restriction ;
            owl:allValuesFrom linkml:Uriorcurie ;
            owl:onProperty biolink:affiliation ],
        biolink:AdministrativeEntity ;
    skos:altLabel "group" ;
    skos:definition "person, group, organization or project that provides a piece of information (i.e. a knowledge association)" ;
    skos:exactMatch dct:Agent,
        prov:Agent ;
    skos:narrowMatch STY:T092,
        STY:T093,
        STY:T094,
        STY:T095,
        STY:T096,
        UMLSSG:ORGA .

biolink:BiologicalProcessOrActivity a owl:Class ;
    rdfs:label "biological process or activity" ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:allValuesFrom biolink:PhysicalEntity ;
            owl:onProperty biolink:enabled_by ],
        [ a owl:Restriction ;
            owl:allValuesFrom biolink:Occurrent ;
            owl:onProperty biolink:has_input ],
        [ a owl:Restriction ;
            owl:allValuesFrom biolink:Occurrent ;
            owl:onProperty biolink:has_output ],
        biolink:BiologicalEntity,
        biolink:Occurrent,
        biolink:OntologyClass ;
    skos:definition "Either an individual molecular activity, or a collection of causally connected molecular activities in a biological system." .

biolink:BiologicalSequence a owl:Class ;
    rdfs:label "biological sequence" ;
    rdfs:subClassOf linkml:String .

biolink:ChemicalOrDrugOrTreatment a owl:Class ;
    rdfs:label "chemical or drug or treatment" ;
    rdfs:subClassOf linkml:mixin .

biolink:onset_qualifier a owl:ObjectProperty ;
    rdfs:label "onset qualifier" ;
    rdfs:domain biolink:Association ;
    rdfs:range biolink:Onset ;
    rdfs:subPropertyOf biolink:qualifier ;
    skos:definition "a qualifier used in a phenotypic association to state when the phenotype appears is in the subject" .

biolink:severity_qualifier a owl:ObjectProperty ;
    rdfs:label "severity qualifier" ;
    rdfs:domain biolink:Association ;
    rdfs:range biolink:SeverityValue ;
    rdfs:subPropertyOf biolink:qualifier ;
    skos:definition "a qualifier used in a phenotypic association to state how severe the phenotype is in the subject" .

biolink:timepoint a owl:ObjectProperty ;
    rdfs:label "timepoint" ;
    rdfs:range biolink:TimeType ;
    skos:altLabel "duration" ;
    skos:definition "a point in time" .

biolink:NucleicAcidEntity a owl:Class ;
    rdfs:label "nucleic acid entity" ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:allValuesFrom biolink:OrganismTaxon ;
            owl:onProperty biolink:in_taxon ],
        [ a owl:Restriction ;
            owl:maxQualifiedCardinality 1 ;
            owl:onClass biolink:BiologicalSequence ;
            owl:onProperty biolink:has_biological_sequence ],
        biolink:GenomicEntity,
        biolink:MolecularEntity,
        biolink:OntologyClass,
        biolink:PhysicalEssence,
        biolink:ThingWithTaxon ;
    skos:altLabel "genomic entity",
        "sequence feature" ;
    skos:definition "A nucleic acid entity is a molecular entity characterized by availability in gene databases of nucleotide-based sequence representations of its precise sequence; for convenience of representation, partial sequences of various kinds are included." ;
    skos:exactMatch <http://purl.obolibrary.org/obo/SO_0000110> ;
    skos:narrowMatch STY:T086,
        STY:T114 .

biolink:Onset a owl:Class ;
    rdfs:label "onset" ;
    rdfs:subClassOf biolink:ClinicalCourse ;
    skos:definition "The age group in which (disease) symptom manifestations appear" ;
    skos:exactMatch <http://purl.obolibrary.org/obo/HP_0003674> .

biolink:SeverityValue a owl:Class ;
    rdfs:label "severity value" ;
    rdfs:subClassOf biolink:Attribute ;
    skos:definition "describes the severity of a phenotypic feature or disease" .

biolink:frequency_qualifier a owl:ObjectProperty ;
    rdfs:label "frequency qualifier" ;
    rdfs:domain biolink:Association ;
    rdfs:range biolink:FrequencyValue ;
    rdfs:subPropertyOf biolink:qualifier ;
    skos:definition "a qualifier used in a phenotypic association to state how frequent the phenotype is observed in the subject" .

biolink:qualifier a owl:ObjectProperty ;
    rdfs:label "qualifier" ;
    rdfs:domain biolink:Association ;
    rdfs:range linkml:String ;
    rdfs:subPropertyOf biolink:association_slot ;
    skos:definition "grouping slot for all qualifiers on an edge.  useful for testing compliance with association classes" .

biolink:FrequencyValue a owl:Class ;
    rdfs:label "frequency value" ;
    rdfs:subClassOf linkml:String .

biolink:BiologicalProcess a owl:Class ;
    rdfs:label "biological process" ;
    rdfs:subClassOf biolink:BiologicalProcessOrActivity,
        biolink:Occurrent,
        biolink:OntologyClass ;
    skos:broadMatch WIKIDATA:P682 ;
    skos:definition "One or more causally connected executions of molecular functions" ;
    skos:exactMatch <http://purl.obolibrary.org/obo/GO_0008150>,
        SIO:000006,
        WIKIDATA:Q2996394 .

biolink:ExposureEvent a owl:Class ;
    rdfs:label "exposure event" ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:maxQualifiedCardinality 1 ;
            owl:onClass biolink:TimeType ;
            owl:onProperty biolink:timepoint ],
        biolink:OntologyClass,
        linkml:mixin ;
    skos:altLabel "experimental condition",
        "exposure" ;
    skos:definition "A (possibly time bounded) incidence of a feature of the environment of an organism that influences one or more phenotypic features of that organism, potentially mediated by genes" ;
    skos:exactMatch <http://purl.obolibrary.org/obo/XCO_0000000> .

biolink:MolecularEntity a owl:Class ;
    rdfs:label "molecular entity" ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:maxQualifiedCardinality 1 ;
            owl:onClass linkml:Boolean ;
            owl:onProperty biolink:is_metabolite ],
        biolink:ChemicalEntity ;
    skos:definition "A molecular entity is a chemical entity composed of individual or covalently bonded atoms." ;
    skos:narrowMatch STY:T085,
        STY:T088,
        <http://purl.obolibrary.org/obo/CHEBI_23367>,
        bioschemas:MolecularEntity .

biolink:TimeType a owl:Class ;
    rdfs:label "time type" ;
    rdfs:subClassOf linkml:Time .

biolink:LabelType a owl:Class ;
    rdfs:label "label type" ;
    rdfs:subClassOf linkml:String .

biolink:OrganismTaxon a owl:Class ;
    rdfs:label "organism taxon" ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:maxQualifiedCardinality 1 ;
            owl:onClass biolink:TaxonomicRank ;
            owl:onProperty biolink:has_taxonomic_rank ],
        biolink:NamedThing ;
    skos:altLabel "taxon",
        "taxonomic classification" ;
    skos:definition "A classification of a set of organisms. Example instances: NCBITaxon:9606 (Homo sapiens), NCBITaxon:2 (Bacteria). Can also be used to represent strains or subspecies." ;
    skos:exactMatch STY:T001,
        bioschemas:Taxon,
        WIKIDATA:Q16521 ;
    skos:narrowMatch dcid:BiologicalSpecies .

biolink:InformationContentEntity a owl:Class ;
    rdfs:label "information content entity" ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:maxQualifiedCardinality 1 ;
            owl:onClass linkml:String ;
            owl:onProperty biolink:license ],
        [ a owl:Restriction ;
            owl:maxQualifiedCardinality 1 ;
            owl:onClass linkml:Date ;
            owl:onProperty biolink:creation_date ],
        [ a owl:Restriction ;
            owl:maxQualifiedCardinality 1 ;
            owl:onClass linkml:String ;
            owl:onProperty biolink:format ],
        [ a owl:Restriction ;
            owl:maxQualifiedCardinality 1 ;
            owl:onClass linkml:String ;
            owl:onProperty biolink:rights ],
        biolink:NamedThing ;
    skos:altLabel "information",
        "information artefact",
        "information entity" ;
    skos:definition "a piece of information that typically describes some topic of discourse or is used as support." ;
    skos:exactMatch IAO:0000030 ;
    skos:narrowMatch STY:T077,
        STY:T078,
        STY:T079,
        STY:T080,
        STY:T081,
        STY:T082,
        STY:T089,
        STY:T102,
        STY:T169,
        STY:T171,
        STY:T185,
        UMLSSG:CONC .

biolink:Publication a owl:Class ;
    rdfs:label "publication" ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:onClass linkml:String ;
            owl:onProperty biolink:id ;
            owl:qualifiedCardinality 1 ],
        [ a owl:Restriction ;
            owl:onClass linkml:String ;
            owl:onProperty dct:type ;
            owl:qualifiedCardinality 1 ],
        [ a owl:Restriction ;
            owl:allValuesFrom linkml:Uriorcurie ;
            owl:onProperty biolink:mesh_terms ],
        [ a owl:Restriction ;
            owl:maxQualifiedCardinality 1 ;
            owl:onClass biolink:LabelType ;
            owl:onProperty rdfs:label ],
        [ a owl:Restriction ;
            owl:maxQualifiedCardinality 1 ;
            owl:onClass linkml:String ;
            owl:onProperty biolink:summary ],
        [ a owl:Restriction ;
            owl:allValuesFrom linkml:String ;
            owl:onProperty biolink:authors ],
        [ a owl:Restriction ;
            owl:allValuesFrom linkml:String ;
            owl:onProperty biolink:pages ],
        [ a owl:Restriction ;
            owl:allValuesFrom linkml:String ;
            owl:onProperty biolink:keywords ],
        biolink:InformationContentEntity ;
    skos:definition "Any published piece of information. Can refer to a whole publication, its encompassing publication (i.e. journal or book) or to a part of a publication, if of significant knowledge scope (e.g. a figure, figure legend, or section highlighted by NLP). The scope is intended to be general and include information published on the web, as well as printed materials, either directly or in one of the Publication Biolink category subclasses." ;
    skos:exactMatch IAO:0000311 ;
    skos:narrowMatch STY:T170,
        IAO:0000013 .

biolink:BiologicalEntity a owl:Class ;
    rdfs:label "biological entity" ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:allValuesFrom biolink:OrganismTaxon ;
            owl:onProperty biolink:in_taxon ],
        biolink:NamedThing,
        biolink:ThingWithTaxon ;
    skos:altLabel "bioentity" ;
    skos:narrowMatch STY:T050,
        SIO:010046,
        WIKIDATA:Q28845870 .

biolink:Attribute a owl:Class ;
    rdfs:label "attribute" ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:maxQualifiedCardinality 1 ;
            owl:onClass biolink:NamedThing ;
            owl:onProperty biolink:has_qualitative_value ],
        [ a owl:Restriction ;
            owl:onClass biolink:OntologyClass ;
            owl:onProperty biolink:has_attribute_type ;
            owl:qualifiedCardinality 1 ],
        [ a owl:Restriction ;
            owl:allValuesFrom biolink:QuantityValue ;
            owl:onProperty biolink:has_quantitative_value ],
        [ a owl:Restriction ;
            owl:maxQualifiedCardinality 1 ;
            owl:onClass biolink:LabelType ;
            owl:onProperty rdfs:label ],
        biolink:NamedThing,
        biolink:OntologyClass ;
    skos:definition "A property or characteristic of an entity. For example, an apple may have properties such as color, shape, age, crispiness. An environmental sample may have attributes such as depth, lat, long, material." ;
    skos:exactMatch SIO:000614 .

biolink:AnatomicalEntity a owl:Class ;
    rdfs:label "anatomical entity" ;
    rdfs:subClassOf biolink:OrganismalEntity,
        biolink:PhysicalEssence ;
    skos:definition "A subcellular location, cell type or gross anatomical part" ;
    skos:exactMatch STY:T017,
        <http://purl.obolibrary.org/obo/CARO_0000000>,
        <http://purl.obolibrary.org/obo/FMA_62955>,
        <http://purl.obolibrary.org/obo/UBERON_0001062>,
        SIO:001262,
        UMLSSG:ANAT,
        WIKIDATA:Q4936952 ;
    skos:narrowMatch <http://purl.obolibrary.org/obo/EMAPA_0>,
        <http://purl.obolibrary.org/obo/FBbt_10000000>,
        <http://purl.obolibrary.org/obo/GO_0110165>,
        <http://purl.obolibrary.org/obo/MA_0000001>,
        <http://purl.obolibrary.org/obo/NCIT_C12219>,
        WBbt:0000100,
        <http://purl.obolibrary.org/obo/XAO_0000000>,
        <http://purl.obolibrary.org/obo/ZFA_0100000> ;
    skos:relatedMatch SNOMEDCT:123037004 .

biolink:SequenceVariant a owl:Class ;
    rdfs:label "sequence variant" ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:allValuesFrom biolink:Gene ;
            owl:onProperty biolink:has_gene ],
        [ a owl:Restriction ;
            owl:maxQualifiedCardinality 1 ;
            owl:onClass biolink:BiologicalSequence ;
            owl:onProperty biolink:has_biological_sequence ],
        [ a owl:Restriction ;
            owl:onClass linkml:String ;
            owl:onProperty biolink:id ;
            owl:qualifiedCardinality 1 ],
        biolink:BiologicalEntity,
        biolink:GenomicEntity,
        biolink:OntologyClass,
        biolink:PhysicalEssence ;
    skos:altLabel "allele" ;
    skos:closeMatch <http://purl.obolibrary.org/obo/GENO_0000002>,
        <http://purl.obolibrary.org/obo/SO_0001060>,
        SIO:010277,
        dcid:Allele,
        VMC:Allele ;
    skos:definition "A sequence_variant is a non exact copy of a sequence_feature or genome exhibiting one or more sequence_alteration." ;
    skos:exactMatch WIKIDATA:Q15304597 ;
    skos:note "This class is for modeling the specific state at a locus. A single DBSNP rs ID could correspond to more than one sequence variants (e.g CIViC:1252 and CIViC:1253, two distinct BRCA2 alleles for rs28897743)" .

biolink:Gene a owl:Class ;
    rdfs:label "gene" ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:maxQualifiedCardinality 1 ;
            owl:onClass linkml:String ;
            owl:onProperty biolink:symbol ],
        [ a owl:Restriction ;
            owl:allValuesFrom biolink:LabelType ;
            owl:onProperty biolink:synonym ],
        [ a owl:Restriction ;
            owl:maxQualifiedCardinality 1 ;
            owl:onClass biolink:BiologicalSequence ;
            owl:onProperty biolink:has_biological_sequence ],
        biolink:BiologicalEntity,
        biolink:ChemicalEntityOrGeneOrGeneProduct,
        biolink:GeneOrGeneProduct,
        biolink:GenomicEntity,
        biolink:OntologyClass,
        biolink:PhysicalEssence ;
    skos:broadMatch <http://purl.obolibrary.org/obo/NCIT_C45822> ;
    skos:definition "A region (or regions) that includes all of the sequence elements necessary to encode a functional transcript. A gene locus may include regulatory regions, transcribed regions and/or other functional sequence regions." ;
    skos:exactMatch <http://purl.obolibrary.org/obo/SO_0000704>,
        SIO:010035,
        dcid:Gene,
        WIKIDATA:Q7187 ;
    skos:narrowMatch bioschemas:gene .

biolink:ChemicalEntity a owl:Class ;
    rdfs:label "chemical entity" ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:maxQualifiedCardinality 1 ;
            owl:onClass linkml:String ;
            owl:onProperty biolink:max_tolerated_dose ],
        [ a owl:Restriction ;
            owl:allValuesFrom biolink:ChemicalRole ;
            owl:onProperty biolink:has_chemical_role ],
        [ a owl:Restriction ;
            owl:maxQualifiedCardinality 1 ;
            owl:onClass linkml:Boolean ;
            owl:onProperty biolink:is_toxic ],
        [ a owl:Restriction ;
            owl:maxQualifiedCardinality 1 ;
            owl:onClass biolink:ChemicalEntity ;
            owl:onProperty biolink:trade_name ],
        [ a owl:Restriction ;
            owl:allValuesFrom biolink:DrugAvailabilityEnum ;
            owl:onProperty biolink:available_from ],
        biolink:ChemicalEntityOrGeneOrGeneProduct,
        biolink:ChemicalEntityOrProteinOrPolypeptide,
        biolink:ChemicalOrDrugOrTreatment,
        biolink:NamedThing,
        biolink:PhysicalEssence ;
    skos:definition "A chemical entity is a physical entity that pertains to chemistry or biochemistry." ;
    skos:exactMatch STY:T103,
        <http://purl.obolibrary.org/obo/CHEBI_24431>,
        SIO:010004,
        WIKIDATA:Q79529 ;
    skos:narrowMatch STY:T129,
        WIKIDATA:Q43460564 .

biolink:ChemicalEntityOrGeneOrGeneProduct a owl:Class ;
    rdfs:label "chemical entity or gene or gene product" ;
    rdfs:subClassOf linkml:mixin ;
    skos:definition "A union of chemical entities and children, and gene or gene product. This mixin is helpful to use when searching across chemical entities that must include genes and their children as chemical entities." .

biolink:GenomicEntity a owl:Class ;
    rdfs:label "genomic entity" ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:maxQualifiedCardinality 1 ;
            owl:onClass biolink:BiologicalSequence ;
            owl:onProperty biolink:has_biological_sequence ],
        linkml:mixin ;
    skos:narrowMatch STY:T028,
        <http://purl.obolibrary.org/obo/GENO_0000897> .

biolink:Occurrent a owl:Class ;
    rdfs:label "occurrent" ;
    rdfs:subClassOf biolink:PhysicalEssenceOrOccurrent,
        linkml:mixin ;
    skos:definition "A processual entity." ;
    skos:exactMatch <http://purl.obolibrary.org/obo/BFO_0000003> .

biolink:DiseaseOrPhenotypicFeature a owl:Class ;
    rdfs:label "disease or phenotypic feature" ;
    rdfs:subClassOf biolink:BiologicalEntity ;
    skos:altLabel "phenome" ;
    skos:definition "Either one of a disease or an individual phenotypic feature. Some knowledge resources such as Monarch treat these as distinct, others such as MESH conflate.  Please see definitions of phenotypic feature and disease in this model for their independent descriptions.  This class is helpful to enforce domains and ranges   that may involve either a disease or a phenotypic feature." ;
    skos:narrowMatch STY:T033 .

rdf:predicate a owl:ObjectProperty ;
    rdfs:label "predicate" ;
    rdfs:domain biolink:Association ;
    rdfs:range biolink:PredicateType ;
    rdfs:subPropertyOf biolink:association_slot ;
    skos:definition "A high-level grouping for the relationship type. AKA minimal predicate. This is analogous to category for nodes." ;
    skos:editorialNote "Has a value from the Biolink related_to hierarchy. In RDF,  this corresponds to rdf:predicate and in Neo4j this corresponds to the relationship type. The convention is for an edge label in snake_case form. For example, biolink:related_to, biolink:causes, biolink:treats" ;
    skos:exactMatch OBAN:association_has_predicate,
        rdf:predicate,
        owl:annotatedProperty .

biolink:PredicateType a owl:Class ;
    rdfs:label "predicate type" ;
    rdfs:subClassOf linkml:Uriorcurie .

biolink:GeneOrGeneProduct a owl:Class ;
    rdfs:label "gene or gene product" ;
    rdfs:subClassOf biolink:MacromolecularMachineMixin,
        linkml:mixin ;
    skos:definition "A union of gene loci or gene products. Frequently an identifier for one will be used as proxy for another" .

biolink:OntologyClass a owl:Class ;
    rdfs:label "ontology class" ;
    rdfs:seeAlso "https://github.com/biolink/biolink-model/issues/486" ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:onClass linkml:String ;
            owl:onProperty biolink:id ;
            owl:qualifiedCardinality 1 ],
        linkml:mixin ;
    skos:definition "a concept or class in an ontology, vocabulary or thesaurus. Note that nodes in a biolink compatible KG can be considered both instances of biolink classes, and OWL classes in their own right. In general you should not need to use this class directly. Instead, use the appropriate biolink class. For example, for the GO concept of endocytosis (GO:0006897), use bl:BiologicalProcess as the type." ;
    skos:exactMatch schema:Class,
        owl:Class ;
    skos:note "Note that formally this is a metaclass. Instances of this class are instances in the graph, but can be the object of 'type' edges. For example, if we had a node in the graph representing a specific brain of a specific patient (e.g brain001), this could have a category of bl:Sample, and by typed more specifically with an ontology class UBERON:nnn, which has as category bl:AnatomicalEntity",
        "This is modeled as a mixin. 'ontology class' should not be the primary type of a node in the KG. Instead you should use an informative bioloink category, such as AnatomicalEntity (for Uberon classes), ChemicalSubstance (for CHEBI or CHEMBL), etc" ;
    linkml:examples "Example(value='UBERON:0000955', description=\"the class 'brain' from the Uberon anatomy ontology\")" .

biolink:association_slot a owl:ObjectProperty ;
    rdfs:label "association slot" ;
    rdfs:domain biolink:Association ;
    rdfs:range linkml:String ;
    skos:altLabel "edge property",
        "edge qualifier",
        "node qualifier",
        "statement property",
        "statement qualifier" ;
    skos:definition "any slot that relates an association to another entity" .

biolink:node_property a owl:ObjectProperty ;
    rdfs:label "node property" ;
    rdfs:domain biolink:NamedThing ;
    rdfs:range linkml:String ;
    skos:definition "A grouping for any property that holds between a node and a value" .

rdf:object a owl:ObjectProperty ;
    rdfs:label "object" ;
    rdfs:domain biolink:Association ;
    rdfs:range biolink:NamedThing ;
    rdfs:subPropertyOf biolink:association_slot ;
    skos:definition "connects an association to the object of the association. For example, in a gene-to-phenotype association, the gene is subject and phenotype is object." ;
    skos:exactMatch OBAN:association_has_object,
        rdf:object,
        owl:annotatedTarget .

rdf:subject a owl:ObjectProperty ;
    rdfs:label "subject" ;
    rdfs:domain biolink:Association ;
    rdfs:range biolink:NamedThing ;
    rdfs:subPropertyOf biolink:association_slot ;
    skos:definition "connects an association to the subject of the association. For example, in a gene-to-phenotype association, the gene is subject and phenotype is object." ;
    skos:exactMatch OBAN:association_has_subject,
        rdf:subject,
        owl:annotatedSource .

biolink:related_to_at_instance_level a owl:ObjectProperty,
        owl:SymmetricProperty ;
    rdfs:label "related to at instance level" ;
    rdfs:domain biolink:NamedThing ;
    rdfs:range biolink:NamedThing ;
    rdfs:subPropertyOf biolink:related_to ;
    skos:definition "Represents a relationship held between two instances of a data classes.  Much like an assertion component, in an ABox, these represent facts associated with the conceptual model." ;
    biolink:canonical_predicate "True" .

biolink:Association a owl:Class ;
    rdfs:label "association" ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:onClass biolink:NamedThing ;
            owl:onProperty rdf:object ;
            owl:qualifiedCardinality 1 ],
        [ a owl:Restriction ;
            owl:onClass biolink:PredicateType ;
            owl:onProperty rdf:predicate ;
            owl:qualifiedCardinality 1 ],
        [ a owl:Restriction ;
            owl:onClass biolink:NamedThing ;
            owl:onProperty rdf:subject ;
            owl:qualifiedCardinality 1 ],
        [ a owl:Restriction ;
            owl:maxQualifiedCardinality 1 ;
            owl:onClass linkml:String ;
            owl:onProperty biolink:original_object ],
        [ a owl:Restriction ;
            owl:maxQualifiedCardinality 1 ;
            owl:onClass biolink:InformationResource ;
            owl:onProperty biolink:knowledge_source ],
        [ a owl:Restriction ;
            owl:allValuesFrom biolink:InformationResource ;
            owl:onProperty biolink:aggregator_knowledge_source ],
        [ a owl:Restriction ;
            owl:allValuesFrom linkml:String ;
            owl:onProperty rdf:type ],
        [ a owl:Restriction ;
            owl:maxQualifiedCardinality 1 ;
            owl:onClass linkml:Uriorcurie ;
            owl:onProperty biolink:original_predicate ],
        [ a owl:Restriction ;
            owl:allValuesFrom biolink:EvidenceType ;
            owl:onProperty biolink:has_evidence ],
        [ a owl:Restriction ;
            owl:maxQualifiedCardinality 1 ;
            owl:onClass biolink:TimeType ;
            owl:onProperty biolink:timepoint ],
        [ a owl:Restriction ;
            owl:allValuesFrom biolink:Publication ;
            owl:onProperty biolink:publications ],
        [ a owl:Restriction ;
            owl:allValuesFrom biolink:OntologyClass ;
            owl:onProperty biolink:qualifiers ],
        [ a owl:Restriction ;
            owl:maxQualifiedCardinality 1 ;
            owl:onClass biolink:InformationResource ;
            owl:onProperty biolink:primary_knowledge_source ],
        [ a owl:Restriction ;
            owl:maxQualifiedCardinality 1 ;
            owl:onClass linkml:Boolean ;
            owl:onProperty biolink:negated ],
        [ a owl:Restriction ;
            owl:maxQualifiedCardinality 1 ;
            owl:onClass linkml:String ;
            owl:onProperty biolink:original_subject ],
        [ a owl:Restriction ;
            owl:allValuesFrom biolink:CategoryType ;
            owl:onProperty biolink:category ],
        biolink:Entity ;
    skos:definition "A typed association between two entities, supported by evidence" ;
    skos:exactMatch OBAN:association,
        rdf:Statement,
        owl:Axiom ;
    skos:note "This is roughly the model used by biolink and ontobio at the moment" .

biolink:NamedThing a owl:Class ;
    rdfs:label "named thing" ;
    rdfs:subClassOf [ a owl:Class ;
            owl:intersectionOf ( [ a owl:Restriction ;
                        owl:allValuesFrom biolink:CategoryType ;
                        owl:onProperty biolink:category ] [ a owl:Restriction ;
                        owl:onProperty biolink:category ;
                        owl:someValuesFrom biolink:CategoryType ] ) ],
        [ a owl:Restriction ;
            owl:allValuesFrom linkml:String ;
            owl:onProperty biolink:provided_by ],
        [ a owl:Restriction ;
            owl:allValuesFrom linkml:Uriorcurie ;
            owl:onProperty biolink:xref ],
        biolink:Entity ;
    skos:definition "a databased entity or concept/class" ;
    skos:exactMatch STY:T071,
        <http://purl.obolibrary.org/obo/BFO_0000001>,
        dcid:Thing,
        UMLSSG:OBJC,
        WIKIDATA:Q35120 .