@prefix AGRKB: <https://www.alliancegenome.org/> .
@prefix CHADO: <http://gmod.org/wiki/Chado/> .
@prefix CHEMBL.MECHANISM: <https://www.ebi.ac.uk/chembl/mechanism/inspect/> .
@prefix CPT: <https://www.ama-assn.org/practice-management/cpt/> .
@prefix CTD: <http://ctdbase.org/> .
@prefix DGIdb: <https://www.dgidb.org/interaction_types> .
@prefix DOID-PROPERTY: <http://purl.obolibrary.org/obo/doid#> .
@prefix DrugCentral: <http://drugcentral.org/drugcard/> .
@prefix ECTO: <http://purl.obolibrary.org/obo/ECTO_> .
@prefix EDAM-DATA: <http://edamontology.org/data_> .
@prefix EFO: <http://www.ebi.ac.uk/efo/EFO_> .
@prefix ExO: <http://purl.obolibrary.org/obo/ExO_> .
@prefix FMA: <http://purl.obolibrary.org/obo/FMA_> .
@prefix FYPO: <http://purl.obolibrary.org/obo/FYPO_> .
@prefix GOREL: <http://purl.obolibrary.org/obo/GOREL_> .
@prefix HANCESTRO: <http://www.ebi.ac.uk/ancestro/ancestro_> .
@prefix HCPCS: <http://purl.bioontology.org/ontology/HCPCS/> .
@prefix HsapDv: <http://purl.obolibrary.org/obo/HsapDv_> .
@prefix IAO: <http://purl.obolibrary.org/obo/IAO_> .
@prefix INO: <http://purl.obolibrary.org/obo/INO_> .
@prefix LOINC: <http://loinc.org/rdf/> .
@prefix MAXO: <http://purl.obolibrary.org/obo/MAXO_> .
@prefix MESH: <http://id.nlm.nih.gov/mesh/> .
@prefix MI: <http://purl.obolibrary.org/obo/MI_> .
@prefix NBO-PROPERTY: <http://purl.obolibrary.org/obo/nbo#> .
@prefix NCIT-OBO: <http://purl.obolibrary.org/obo/ncit#> .
@prefix NDDF: <http://purl.bioontology.org/ontology/NDDF/> .
@prefix OBAN: <http://purl.org/oban/> .
@prefix OIO: <http://www.geneontology.org/formats/oboInOwl#> .
@prefix ORDO: <http://www.orpha.net/ORDO/> .
@prefix PHAROS: <http://pharos.nih.gov> .
@prefix PathWhiz: <http://smpdb.ca/pathways/#> .
@prefix REPODB: <http://apps.chiragjpgroup.org/repoDB/> .
@prefix RO: <http://purl.obolibrary.org/obo/RO_> .
@prefix RXNORM: <http://purl.bioontology.org/ontology/RXNORM/> .
@prefix SEMMEDDB: <https://skr3.nlm.nih.gov/SemMedDB> .
@prefix SIO: <http://semanticscience.org/resource/SIO_> .
@prefix SNOMEDCT: <http://snomed.info/id/> .
@prefix STY: <http://purl.bioontology.org/ontology/STY/> .
@prefix UBERGRAPH: <http://translator.renci.org/ubergraph-axioms.ofn#> .
@prefix UBERON_CORE: <http://purl.obolibrary.org/obo/uberon/core#> .
@prefix UBERON_NONAMESPACE: <http://purl.obolibrary.org/obo/core#> .
@prefix UMLSSG: <https://lhncbc.nlm.nih.gov/semanticnetwork/download/sg_archive/SemGroups-v04.txt> .
@prefix UO-PROPERTY: <http://purl.obolibrary.org/obo/uo#> .
@prefix VANDF: <https://www.nlm.nih.gov/research/umls/sourcereleasedocs/current/VANDF/> .
@prefix VMC: <https://github.com/ga4gh/vr-spec/> .
@prefix WBVocab: <http://bio2rdf.org/wormbase_vocabulary> .
@prefix WBbt: <http://purl.obolibrary.org/obo/WBbt_> .
@prefix WIKIDATA: <https://www.wikidata.org/entity/> .
@prefix WIKIDATA_PROPERTY: <https://www.wikidata.org/prop/> .
@prefix XPO: <http://purl.obolibrary.org/obo/XPO_> .
@prefix biolink: <https://w3id.org/biolink/vocab/> .
@prefix bioschemas: <https://bioschemas.org/> .
@prefix dcat: <http://www.w3.org/ns/dcat#> .
@prefix dcid: <https://datacommons.org/browser/> .
@prefix dcmitype: <http://purl.org/dc/dcmitype/> .
@prefix dct: <http://purl.org/dc/terms/> .
@prefix fabio: <http://purl.org/spar/fabio/> .
@prefix foaf: <http://xmlns.com/foaf/0.1/> .
@prefix gff3: <https://github.com/The-Sequence-Ontology/Specifications/blob/master/gff3.md#> .
@prefix gpi: <https://github.com/geneontology/go-annotation/blob/master/specs/gpad-gpi-2-0.md#> .
@prefix linkml: <https://w3id.org/linkml/> .
@prefix os: <https://github.com/cmungall/owlstar/blob/master/owlstar.ttl> .
@prefix owl: <http://www.w3.org/2002/07/owl#> .
@prefix pav: <http://purl.org/pav/> .
@prefix prov: <http://www.w3.org/ns/prov#> .
@prefix qud: <http://qudt.org/1.1/schema/qudt#> .
@prefix rdf: <http://www.w3.org/1999/02/22-rdf-syntax-ns#> .
@prefix rdfs: <http://www.w3.org/2000/01/rdf-schema#> .
@prefix schema1: <http://schema.org/> .
@prefix skos: <http://www.w3.org/2004/02/skos/core#> .
@prefix wgs1: <http://www.w3.org/2003/01/geo/wgs84_pos> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<http://purl.obolibrary.org/obo/UO_0000187> a rdfs:Datatype ;
    owl:equivalentClass xsd:double .

<http://purl.obolibrary.org/obo/UO_0010006> a rdfs:Datatype ;
    owl:equivalentClass xsd:double .

<https://w3id.org/biolink/vocab/.owl.ttl> a owl:Ontology ;
    rdfs:label "Biolink-Model" ;
    dct:license "https://creativecommons.org/publicdomain/zero/1.0/" ;
    pav:version "4.4.6" ;
    skos:definition "Entity and association taxonomy and datamodel for life-sciences data" .

biolink:BehavioralOutcome a owl:Class ;
    rdfs:label "behavioral outcome" ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:onProperty linkml:mixins ;
            owl:someValuesFrom biolink:Outcome ],
        linkml:ClassDefinition ;
    skos:definition "An outcome resulting from an exposure event which is the manifestation of human behavior." ;
    skos:inScheme biolink: .

biolink:DiseaseOrPhenotypicFeatureOutcome a owl:Class ;
    rdfs:label "disease or phenotypic feature outcome" ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:onProperty linkml:mixins ;
            owl:someValuesFrom biolink:Outcome ],
        linkml:ClassDefinition ;
    skos:definition "Physiological outcomes resulting from an exposure event which is the manifestation of a disease or other characteristic phenotype." ;
    skos:inScheme biolink: .

biolink:Edge a owl:Class ;
    rdfs:label "Edge" ;
    rdfs:subClassOf linkml:ClassDefinition ;
    skos:definition "A generic edge in a KGX-formatted knowledge graph, representing a directed relationship between a subject node and an object node qualified by a predicate. This class serves as the structural superclass for `association` in Biolink, providing the minimal KGX-compliant contract (subject, predicate, object, and associated metadata) that any biolink relationship participating in a knowledge graph must satisfy." ;
    skos:inScheme biolink: .

biolink:EntityToFeatureOrDiseaseQualifiersMixin a owl:Class ;
    rdfs:label "entity to feature or disease qualifiers mixin" ;
    rdfs:subClassOf linkml:ClassDefinition ;
    skos:definition "DEPRECATED. An accidental duplicate of 'entity to disease or phenotypic feature association mixin' - \"feature\" here was shorthand for \"phenotypic feature\", so the two classes named the same scope while carrying disjoint slots. Use 'entity to disease or phenotypic feature association mixin' instead; this class now inherits from it and adds nothing." ;
    skos:inScheme biolink: .

biolink:EpidemiologicalOutcome a owl:Class ;
    rdfs:label "epidemiological outcome" ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:onProperty linkml:mixins ;
            owl:someValuesFrom biolink:Outcome ],
        linkml:ClassDefinition ;
    skos:definition "An epidemiological outcome, such as societal disease burden, resulting from an exposure event." ;
    skos:inScheme biolink: ;
    skos:relatedMatch <http://purl.obolibrary.org/obo/NCIT_C19291> .

biolink:HospitalizationOutcome a owl:Class ;
    rdfs:label "hospitalization outcome" ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:onProperty linkml:mixins ;
            owl:someValuesFrom biolink:Outcome ],
        linkml:ClassDefinition ;
    skos:definition "An outcome resulting from an exposure event which is the increased manifestation of acute (e.g. emergency room visit) or chronic (inpatient) hospitalization." ;
    skos:inScheme biolink: .

biolink:KnowledgeGraph a owl:Class ;
    rdfs:label "KnowledgeGraph",
        "knowledge graph" ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:minCardinality 0 ;
            owl:onProperty biolink:edges ],
        [ a owl:Restriction ;
            owl:allValuesFrom biolink:Entity ;
            owl:onProperty biolink:nodes ],
        [ a owl:Restriction ;
            owl:allValuesFrom biolink:Association ;
            owl:onProperty biolink:edges ],
        [ a owl:Restriction ;
            owl:allValuesFrom biolink:Association ;
            owl:onProperty biolink:edges ],
        [ a owl:Restriction ;
            owl:minCardinality 0 ;
            owl:onProperty biolink:edges ],
        [ a owl:Restriction ;
            owl:minCardinality 0 ;
            owl:onProperty biolink:nodes ],
        [ a owl:Restriction ;
            owl:minCardinality 0 ;
            owl:onProperty biolink:nodes ],
        [ a owl:Restriction ;
            owl:allValuesFrom biolink:Entity ;
            owl:onProperty biolink:nodes ],
        linkml:ClassDefinition ;
    skos:definition "A container representing a knowledge graph serialized in KGX (Knowledge Graph Exchange) format. A KnowledgeGraph aggregates a collection of nodes (entities) and edges (relationships between entities) conforming to the KGX specification, enabling interoperable exchange of biomedical knowledge graphs across tools and systems in the Biolink ecosystem.",
        "A knowledge graph is a structured representation of knowledge in the form of a graph, where nodes represent entities or concepts, and edges represent relationships between them. Knowledge graphs are used to organize and connect information from various sources, enabling better understanding, analysis, and reasoning about complex domains." ;
    skos:inScheme biolink: .

biolink:MappingCollection a owl:Class ;
    rdfs:label "mapping collection" ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:allValuesFrom biolink:PredicateMapping ;
            owl:onProperty biolink:predicate_mappings ],
        [ a owl:Restriction ;
            owl:minCardinality 0 ;
            owl:onProperty biolink:predicate_mappings ],
        linkml:ClassDefinition ;
    skos:definition "An abstract container class that holds a set of predicate mappings. Serves as a top-level root for documents that enumerate how third-party or deprecated predicates should be rewritten to Biolink predicates and their associated qualifiers." ;
    skos:inScheme biolink: .

biolink:MortalityOutcome a owl:Class ;
    rdfs:label "mortality outcome" ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:onProperty linkml:mixins ;
            owl:someValuesFrom biolink:Outcome ],
        linkml:ClassDefinition ;
    skos:definition "An outcome of death from resulting from an exposure event." ;
    skos:inScheme biolink: .

biolink:Node a owl:Class ;
    rdfs:label "Node" ;
    rdfs:subClassOf linkml:ClassDefinition ;
    skos:definition "A generic node in a KGX-formatted knowledge graph, representing a single entity or concept with a unique identifier. This class serves as the structural superclass for `named thing` in Biolink, providing the minimal KGX-compliant contract (identifier, category, etc.) that any biolink entity participating in a knowledge graph must satisfy." ;
    skos:inScheme biolink: .

biolink:PathologicalAnatomicalOutcome a owl:Class ;
    rdfs:label "pathological anatomical outcome" ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:onProperty linkml:mixins ;
            owl:someValuesFrom biolink:Outcome ],
        linkml:ClassDefinition ;
    skos:definition "An outcome resulting from an exposure event which is the manifestation of an abnormal anatomical structure." ;
    skos:inScheme biolink: .

biolink:PathologicalProcessOutcome a owl:Class ;
    rdfs:label "pathological process outcome" ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:onProperty linkml:mixins ;
            owl:someValuesFrom biolink:Outcome ],
        linkml:ClassDefinition ;
    skos:definition "An outcome resulting from an exposure event which is the manifestation of a pathological process." ;
    skos:inScheme biolink: .

biolink:RelationshipType a owl:Class ;
    rdfs:label "relationship type" ;
    rdfs:subClassOf biolink:OntologyClass ;
    skos:definition "An OWL property used as an edge label" ;
    skos:inScheme biolink: .

biolink:SocioeconomicOutcome a owl:Class ;
    rdfs:label "socioeconomic outcome" ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:onProperty linkml:mixins ;
            owl:someValuesFrom biolink:Outcome ],
        linkml:ClassDefinition ;
    skos:definition "An general social or economic outcome, such as healthcare costs, utilization, etc., resulting from an exposure event" ;
    skos:inScheme biolink: .

biolink:adverse_event_of a owl:ObjectProperty ;
    rdfs:label "adverse event of" ;
    rdfs:domain biolink:DiseaseOrPhenotypicFeature ;
    rdfs:range biolink:ChemicalOrDrugOrTreatment ;
    rdfs:subPropertyOf biolink:affected_by ;
    owl:inverseOf biolink:has_adverse_event ;
    skos:inScheme biolink: .

biolink:amount_or_activity_decreased_by a owl:DatatypeProperty ;
    rdfs:label "amount or activity decreased by" ;
    rdfs:subPropertyOf biolink:related_to_at_instance_level ;
    owl:inverseOf biolink:decreases_amount_or_activity_of ;
    skos:inScheme biolink: .

biolink:amount_or_activity_increased_by a owl:DatatypeProperty ;
    rdfs:label "amount or activity increased by" ;
    rdfs:subPropertyOf biolink:related_to_at_instance_level ;
    owl:inverseOf biolink:increases_amount_or_activity_of ;
    skos:inScheme biolink: .

biolink:animal_model_available_from a owl:DatatypeProperty ;
    rdfs:label "animal model available from" ;
    rdfs:range xsd:string ;
    rdfs:subPropertyOf biolink:node_property ;
    skos:definition "A resource (such as a model organism database) from which an animal model representing the given disease or phenotypic feature may be obtained. " ;
    skos:inScheme biolink: .

biolink:binds a owl:DatatypeProperty,
        owl:SymmetricProperty ;
    rdfs:label "binds" ;
    rdfs:subPropertyOf biolink:directly_physically_interacts_with ;
    skos:closeMatch DGIdb:binder ;
    skos:definition "A causal mechanism mediated by the direct contact between effector and target chemical or biomolecular entity, which form a stable physical interaction." ;
    skos:inScheme biolink: ;
    biolink:canonical_predicate true .

biolink:biological_role_mixin a owl:DatatypeProperty ;
    rdfs:label "biological role mixin" ;
    skos:definition "A role played by the chemical entity or part thereof within a biological context." ;
    skos:inScheme biolink: ;
    skos:narrowMatch <http://purl.obolibrary.org/obo/CHEBI_24432> .

biolink:bonferonni_adjusted_p_value a owl:DatatypeProperty ;
    rdfs:label "bonferonni adjusted p value" ;
    rdfs:range xsd:float ;
    rdfs:subPropertyOf biolink:adjusted_p_value ;
    skos:definition "The Bonferroni correction is an adjustment made to P values when several dependent or independent statistical tests are being performed simultaneously on a single data set. To perform a Bonferroni correction, divide the critical P value (α) by the number of comparisons being made.  P is always italicized and capitalized. The actual P value* should be expressed (P=. 04) rather than expressing a statement of inequality (P<. 05), unless P<." ;
    skos:inScheme biolink: .

biolink:broad_matches a owl:DatatypeProperty ;
    rdfs:label "broad matches" ;
    skos:definition "A list of terms from different schemas or terminology systems that have a broader meaning. Such terms often describe a more general concept from different ontological perspectives." ;
    skos:inScheme biolink: .

biolink:can_be_carried_out_by a owl:ObjectProperty ;
    rdfs:label "can be carried out by" ;
    rdfs:domain biolink:Occurrent ;
    rdfs:range biolink:NamedThing ;
    rdfs:subPropertyOf biolink:actively_involves ;
    owl:inverseOf biolink:capable_of ;
    skos:inScheme biolink: .

biolink:caused_by a owl:DatatypeProperty ;
    rdfs:label "caused by" ;
    rdfs:subPropertyOf biolink:contribution_from ;
    owl:inverseOf biolink:causes ;
    skos:altLabel "disease caused by disruption of",
        "disease has basis in dysfunction of",
        "realized in response to",
        "realized in response to stimulus" ;
    skos:definition "holds between two entities where the occurrence, existence, or activity of one is caused by the occurrence or generation of the other" ;
    skos:exactMatch WIKIDATA_PROPERTY:P828 ;
    skos:inScheme biolink: ;
    skos:narrowMatch RO:0001022,
        RO:0002608,
        RO:0004019,
        RO:0004020,
        RO:0004028,
        RO:0009501 .

biolink:chembl_assay_description a owl:DatatypeProperty ;
    rdfs:label "chembl assay description" ;
    rdfs:range xsd:string ;
    skos:definition "Text describing the assay associated with a chemical entity." ;
    skos:inScheme <https://w3id.org/biolink/biolink-model/attributes> .

biolink:chembl_binding_site_comment a owl:DatatypeProperty ;
    rdfs:label "chembl binding site comment" ;
    rdfs:range xsd:string ;
    skos:definition "Text describing the binding site for a chemical entity." ;
    skos:inScheme <https://w3id.org/biolink/biolink-model/attributes> .

biolink:chembl_binding_site_name a owl:DatatypeProperty ;
    rdfs:label "chembl binding site name" ;
    rdfs:range xsd:string ;
    skos:definition "Text indicating the name of the binding site for a chemical entity." ;
    skos:inScheme <https://w3id.org/biolink/biolink-model/attributes> .

biolink:chembl_confidence_score a owl:DatatypeProperty ;
    rdfs:label "chembl confidence score" ;
    rdfs:range xsd:integer ;
    skos:definition "A score defined by ChEMBL that represents the confidence level of a particular drug-target  interaction, based on the type and quality of evidence supporting the interaction. The score  ranges from 0 to 9, with higher scores indicating stronger evidence for the interaction." ;
    skos:inScheme <https://w3id.org/biolink/biolink-model/attributes> .

biolink:chembl_mechanism_of_action_comment a owl:DatatypeProperty ;
    rdfs:label "chembl mechanism of action comment" ;
    rdfs:range xsd:string ;
    skos:definition "Additional comments regarding the mechanism of action." ;
    skos:inScheme <https://w3id.org/biolink/biolink-model/attributes> .

biolink:chembl_mechanism_of_action_description a owl:DatatypeProperty ;
    rdfs:label "chembl mechanism of action description" ;
    rdfs:range xsd:string ;
    skos:definition "Text describing the mechanism of action for a chemical entity." ;
    skos:inScheme <https://w3id.org/biolink/biolink-model/attributes> .

biolink:chembl_mutation a owl:DatatypeProperty ;
    rdfs:label "chembl mutation" ;
    rdfs:range xsd:string ;
    skos:definition "Text describing mutations associated with a chemical entity." ;
    skos:inScheme <https://w3id.org/biolink/biolink-model/attributes> .

biolink:chembl_mutation_accession a owl:DatatypeProperty ;
    rdfs:label "chembl mutation accession" ;
    rdfs:range xsd:string ;
    skos:definition "Accession identifier for a mutation associated with a chemical entity." ;
    skos:inScheme <https://w3id.org/biolink/biolink-model/attributes> .

biolink:chembl_selectivity_comment a owl:DatatypeProperty ;
    rdfs:label "chembl selectivity comment" ;
    rdfs:range xsd:string ;
    skos:definition "Additional comments regarding the selectivity of the drug." ;
    skos:inScheme <https://w3id.org/biolink/biolink-model/attributes> .

biolink:chemical_entity_or_drug_or_treatment a owl:DatatypeProperty ;
    rdfs:label "chemical entity or drug or treatment" ;
    skos:definition "A union of chemical entities and children, and drug or treatment." ;
    skos:inScheme biolink: .

biolink:chemical_role_mixin a owl:DatatypeProperty ;
    rdfs:label "chemical role mixin" ;
    skos:definition "A role played by the chemical entity or part thereof within a chemical context." ;
    skos:exactMatch <http://purl.obolibrary.org/obo/CHEBI_51086> ;
    skos:inScheme biolink: .

biolink:chemically_similar_to a owl:DatatypeProperty,
        owl:SymmetricProperty ;
    rdfs:label "chemically similar to" ;
    rdfs:subPropertyOf biolink:similar_to ;
    skos:definition "holds between one small molecule entity and another that it approximates for purposes of scientific study, in virtue of its exhibiting similar features of the studied entity." ;
    skos:inScheme biolink: ;
    skos:narrowMatch <http://purl.obolibrary.org/obo/CHEBI_has_functional_parent>,
        <http://purl.obolibrary.org/obo/CHEBI_has_parent_hydride>,
        <http://purl.obolibrary.org/obo/CHEBI_is_conjugate_acid_of>,
        <http://purl.obolibrary.org/obo/CHEBI_is_conjugate_base_of>,
        <http://purl.obolibrary.org/obo/CHEBI_is_enantiomer_of>,
        <http://purl.obolibrary.org/obo/CHEBI_is_tautomer_of>,
        <http://purl.obolibrary.org/obo/NCIT_has_salt_form> ;
    biolink:canonical_predicate true .

biolink:clinical_modifier_qualifier a owl:ObjectProperty ;
    rdfs:label "clinical modifier qualifier" ;
    rdfs:range biolink:ClinicalModifier ;
    rdfs:subPropertyOf biolink:association_slot ;
    skos:definition "the method or process of administering a pharmaceutical compound to achieve a therapeutic effect in humans or animals." ;
    skos:inScheme biolink: .

biolink:clinical_trial_intervention_boxed_warning a owl:DatatypeProperty ;
    rdfs:label "clinical trial intervention boxed warning" ;
    rdfs:domain biolink:Association ;
    rdfs:range xsd:boolean ;
    rdfs:subPropertyOf biolink:node_property ;
    skos:definition "A boolean flag indicating whether a clinical trial intervention has a boxed warning. A boxed warning is the strongest warning that the FDA requires on a prescription drug label. This property should be populated from DailyMed." ;
    skos:inScheme biolink: .

biolink:clinical_trial_time_perspective a owl:DatatypeProperty ;
    rdfs:label "clinical trial time perspective" ;
    rdfs:domain biolink:ClinicalTrial ;
    rdfs:range xsd:string ;
    rdfs:subPropertyOf biolink:node_property ;
    skos:definition "The time perspective of a clinical trial as determined by clinicaltrials.gov.  The most common values are PROSPECTIVE, RETROSPECTIVE, CROSS_SECTIONAL, or OTHER (most common).." ;
    skos:inScheme biolink: .

biolink:coexpressed_with a owl:ObjectProperty,
        owl:SymmetricProperty ;
    rdfs:label "coexpressed with" ;
    rdfs:domain biolink:GeneOrGeneProduct ;
    rdfs:range biolink:GeneOrGeneProduct ;
    rdfs:subPropertyOf biolink:correlated_with ;
    skos:definition "holds between any two genes or gene products, in which both are generally expressed within a single defined experimental context." ;
    skos:inScheme biolink: ;
    biolink:canonical_predicate true .

biolink:colocalizes_with a owl:DatatypeProperty,
        owl:SymmetricProperty ;
    rdfs:label "colocalizes with" ;
    rdfs:subPropertyOf biolink:coexists_with ;
    skos:definition "holds between two entities that are observed to be located in the same place." ;
    skos:exactMatch RO:0002325 ;
    skos:inScheme biolink: ;
    biolink:canonical_predicate true .

biolink:completed_by a owl:DatatypeProperty ;
    rdfs:label "completed by" ;
    rdfs:subPropertyOf biolink:related_to_at_instance_level ;
    owl:inverseOf biolink:has_completed ;
    skos:inScheme biolink: .

biolink:concept_count_object a owl:DatatypeProperty ;
    rdfs:label "concept count object" ;
    rdfs:range xsd:integer ;
    rdfs:subPropertyOf biolink:association_slot ;
    skos:definition "The number of instances in a dataset/cohort whose records contain the concept in the object slot of an association." ;
    skos:inScheme biolink: .

biolink:concept_count_subject a owl:DatatypeProperty ;
    rdfs:label "concept count subject" ;
    rdfs:range xsd:integer ;
    rdfs:subPropertyOf biolink:association_slot ;
    skos:definition "The number of instances in a dataset/cohort whose records contain the concept in the subject slot of an association." ;
    skos:inScheme biolink: .

biolink:concept_pair_count a owl:DatatypeProperty ;
    rdfs:label "concept pair count" ;
    rdfs:range xsd:integer ;
    rdfs:subPropertyOf biolink:association_slot ;
    skos:definition "The number of instances in a dataset/cohort whose records contain both the subject and object concept of an association." ;
    skos:inScheme biolink: .

biolink:condition_ameliorated_by a owl:ObjectProperty ;
    rdfs:label "condition ameliorated by" ;
    rdfs:domain biolink:DiseaseOrPhenotypicFeature ;
    rdfs:range biolink:ChemicalOrDrugOrTreatment ;
    rdfs:subPropertyOf biolink:affected_by ;
    owl:inverseOf biolink:ameliorates_condition ;
    skos:inScheme biolink: .

biolink:condition_associated_with_gene a owl:ObjectProperty ;
    rdfs:label "condition associated with gene" ;
    rdfs:domain biolink:DiseaseOrPhenotypicFeature ;
    rdfs:range biolink:Gene ;
    rdfs:subPropertyOf biolink:genetically_associated_with ;
    owl:inverseOf biolink:gene_associated_with_condition ;
    skos:altLabel "disease associated with gene" ;
    skos:definition "holds between a gene and a disease or phenotypic feature that may be influenced, contribute to, or be correlated with the gene or its alleles/products" ;
    skos:inScheme biolink: ;
    skos:narrowMatch <http://purl.obolibrary.org/obo/NCIT_R176>,
        RO:0004000 .

biolink:condition_exacerbated_by a owl:ObjectProperty ;
    rdfs:label "condition exacerbated by" ;
    rdfs:domain biolink:DiseaseOrPhenotypicFeature ;
    rdfs:range biolink:ChemicalOrDrugOrTreatment ;
    rdfs:subPropertyOf biolink:affected_by ;
    owl:inverseOf biolink:exacerbates_condition ;
    skos:inScheme biolink: .

biolink:condition_predisposed_by a owl:ObjectProperty ;
    rdfs:label "condition predisposed by" ;
    rdfs:domain biolink:DiseaseOrPhenotypicFeature ;
    rdfs:range biolink:ChemicalOrDrugOrTreatment ;
    rdfs:subPropertyOf biolink:likelihood_affected_by ;
    owl:inverseOf biolink:predisposes_to_condition ;
    skos:inScheme biolink: .

biolink:condition_promoted_by a owl:ObjectProperty ;
    rdfs:label "condition promoted by" ;
    rdfs:domain biolink:DiseaseOrPhenotypicFeature ;
    rdfs:range biolink:ChemicalOrDrugOrTreatment ;
    rdfs:subPropertyOf biolink:likelihood_affected_by ;
    owl:inverseOf biolink:promotes_condition ;
    skos:inScheme biolink: .

biolink:consumed_by a owl:ObjectProperty ;
    rdfs:label "consumed by" ;
    rdfs:domain biolink:NamedThing ;
    rdfs:range biolink:NamedThing ;
    rdfs:subPropertyOf biolink:is_input_of ;
    owl:inverseOf biolink:consumes ;
    skos:inScheme biolink: .

biolink:contains_process a owl:DatatypeProperty ;
    rdfs:label "contains process" ;
    rdfs:subPropertyOf biolink:related_to_at_instance_level ;
    owl:inverseOf biolink:occurs_in ;
    skos:inScheme biolink: .

biolink:created_with a owl:DatatypeProperty ;
    rdfs:label "created with" ;
    rdfs:domain biolink:Dataset ;
    rdfs:subPropertyOf biolink:node_property ;
    skos:definition "An identifier (typically a URL or CURIE) of the software tool, service, or pipeline used to create the dataset." ;
    skos:exactMatch pav:createdWith ;
    skos:inScheme biolink: .

biolink:dataset_download_url a owl:DatatypeProperty ;
    rdfs:label "dataset download url" ;
    rdfs:domain biolink:Dataset ;
    rdfs:subPropertyOf biolink:node_property ;
    skos:definition "A URL from which the dataset itself may be directly downloaded specialised for the dataset domain." ;
    skos:inScheme biolink: .

biolink:decreased_amount_in a owl:DatatypeProperty ;
    rdfs:label "decreased amount in" ;
    rdfs:subPropertyOf biolink:related_to_at_instance_level ;
    owl:inverseOf biolink:has_decreased_amount ;
    skos:inScheme biolink: .

biolink:decreased_likelihood_associated_with a owl:DatatypeProperty ;
    rdfs:label "decreased likelihood associated with" ;
    rdfs:subPropertyOf biolink:likelihood_associated_with ;
    owl:inverseOf biolink:associated_with_decreased_likelihood_of ;
    skos:inScheme biolink: .

biolink:develops_into a owl:DatatypeProperty ;
    rdfs:label "develops into" ;
    rdfs:subPropertyOf biolink:related_to_at_instance_level ;
    owl:inverseOf biolink:develops_from ;
    skos:inScheme biolink: .

biolink:dgidb_relative_drug_specificity_score a owl:DatatypeProperty ;
    rdfs:label "dgidb relative drug specificity score" ;
    rdfs:range xsd:float ;
    skos:definition "A score defined by DGIdb that quantifies the gene-interaction specificity of a given drug - representing the ratio of average known gene partners for all drugs to the known partners for the given drug. See https://dgidb.org/about/overview/interaction-score." ;
    skos:inScheme <https://w3id.org/biolink/biolink-model/attributes> .

biolink:dgidb_relative_gene_specificity_score a owl:DatatypeProperty ;
    rdfs:label "dgidb relative gene specificity score" ;
    rdfs:range xsd:float ;
    skos:definition "A score defined by DGIdb that quantifies the drug-interaction specificity of a given gene - representing the ratio of average known drug partners for all genes to the known partners for the given gene. See https://dgidb.org/about/overview/interaction-score." ;
    skos:inScheme <https://w3id.org/biolink/biolink-model/attributes> .

biolink:disrupted_by a owl:DatatypeProperty ;
    rdfs:label "disrupted by" ;
    rdfs:subPropertyOf biolink:affected_by ;
    owl:inverseOf biolink:disrupts ;
    skos:definition "describes a relationship where the structure, function, or occurrence of one entity is degraded or interfered with by another." ;
    skos:inScheme biolink: .

biolink:download_url a owl:DatatypeProperty ;
    rdfs:label "download url" ;
    rdfs:domain biolink:InformationContentEntity ;
    rdfs:subPropertyOf biolink:node_property ;
    skos:definition "A URL from which the information content entity may be directly downloaded in its native serialization." ;
    skos:inScheme biolink: .

biolink:drug_rep_hub_disease_area a owl:DatatypeProperty ;
    rdfs:label "drug_rep_hub disease area" ;
    rdfs:range xsd:string ;
    skos:definition "A term used by Drug Repurposing Hub to describe the disease area associated with a drug." ;
    skos:inScheme <https://w3id.org/biolink/biolink-model/attributes> .

biolink:end_coordinate a owl:DatatypeProperty ;
    rdfs:label "end coordinate" ;
    rdfs:subPropertyOf biolink:base_coordinate ;
    skos:altLabel "end" ;
    skos:closeMatch <http://biohackathon.org/resource/faldo#end> ;
    skos:definition "The position at which the subject genomic entity ends on the chromosome or other entity to which it is located on." ;
    skos:exactMatch gff3:end ;
    skos:inScheme biolink: .

biolink:exact_matches a owl:DatatypeProperty ;
    rdfs:label "exact matches" ;
    skos:definition "A list of terms from different schemas or terminology systems that have an identical meaning. Such terms often describe the same concept from different ontological perspectives." ;
    skos:inScheme biolink: .

biolink:expected_count a owl:DatatypeProperty ;
    rdfs:label "expected count" ;
    rdfs:subPropertyOf biolink:association_slot ;
    skos:definition "The expected (calculated) number of instances in a dataset/cohort whose records contain both the subject and object concept of an association if the subject and object concepts are independent." ;
    skos:inScheme biolink: .

biolink:expresses a owl:ObjectProperty ;
    rdfs:label "expresses" ;
    rdfs:domain biolink:AnatomicalEntity ;
    rdfs:range biolink:GeneOrGeneProduct ;
    rdfs:subPropertyOf biolink:location_of ;
    owl:inverseOf biolink:expressed_in ;
    skos:altLabel "anatomy expresses gene" ;
    skos:definition "holds between an anatomical entity and gene or gene product that is expressed there" ;
    skos:exactMatch RO:0002292 ;
    skos:inScheme biolink: .

biolink:gene_fusion_with a owl:ObjectProperty,
        owl:SymmetricProperty ;
    rdfs:label "gene_fusion_with" ;
    rdfs:domain biolink:Gene ;
    rdfs:range biolink:Gene ;
    rdfs:subPropertyOf biolink:genetically_interacts_with ;
    skos:definition "holds between two independent genes that have fused through translocation, interstitial deletion, or chromosomal inversion to form a new, hybrid gene. Fusion genes are often implicated in various neoplasms and cancers." ;
    skos:inScheme biolink: ;
    biolink:canonical_predicate true .

biolink:genetic_association a owl:DatatypeProperty,
        owl:SymmetricProperty ;
    rdfs:label "genetic association" ;
    rdfs:subPropertyOf biolink:associated_with ;
    skos:inScheme biolink: .

biolink:genetic_neighborhood_of a owl:ObjectProperty,
        owl:SymmetricProperty ;
    rdfs:label "genetic_neighborhood_of" ;
    rdfs:domain biolink:Gene ;
    rdfs:range biolink:Gene ;
    rdfs:subPropertyOf biolink:genetically_interacts_with ;
    skos:definition "holds between two genes located nearby one another on a chromosome." ;
    skos:inScheme biolink: ;
    biolink:canonical_predicate true .

biolink:has_active_component a owl:ObjectProperty ;
    rdfs:label "has active component" ;
    rdfs:domain biolink:CellularComponent ;
    rdfs:range biolink:GeneOrGeneProduct ;
    rdfs:subPropertyOf biolink:location_of ;
    owl:inverseOf biolink:active_in ;
    skos:inScheme biolink: .

biolink:has_author a owl:ObjectProperty ;
    rdfs:label "has author" ;
    rdfs:domain biolink:Publication ;
    rdfs:range biolink:Agent ;
    rdfs:subPropertyOf biolink:has_contributor ;
    owl:inverseOf biolink:author ;
    skos:inScheme biolink: .

biolink:has_biomarker a owl:ObjectProperty ;
    rdfs:label "has biomarker" ;
    rdfs:domain biolink:DiseaseOrPhenotypicFeature ;
    rdfs:range biolink:ChemicalEntityOrGeneOrGeneProduct ;
    rdfs:subPropertyOf biolink:correlated_with ;
    owl:inverseOf biolink:biomarker_for ;
    skos:definition """holds between a disease or phenotypic feature and a measurable chemical entity that is used as an indicator of the presence or state of the disease or feature.
 # metabolite""" ;
    skos:inScheme biolink: ;
    skos:narrowMatch <http://purl.obolibrary.org/obo/NCIT_disease_has_molecular_abnormality>,
        <http://purl.obolibrary.org/obo/NCIT_disease_is_marked_by_gene> .

biolink:has_catalyst a owl:DatatypeProperty ;
    rdfs:label "has catalyst" ;
    rdfs:subPropertyOf biolink:has_participant ;
    owl:inverseOf biolink:catalyzes ;
    skos:inScheme biolink: .

biolink:has_chemical_formula a owl:DatatypeProperty ;
    rdfs:label "has chemical formula" ;
    rdfs:range xsd:string ;
    rdfs:subPropertyOf biolink:node_property ;
    skos:definition "description of chemical compound based on element symbols" ;
    skos:exactMatch WIKIDATA_PROPERTY:P274 ;
    skos:inScheme biolink: .

biolink:has_confidence_level a owl:DatatypeProperty ;
    rdfs:label "has confidence level" ;
    rdfs:subPropertyOf biolink:association_slot ;
    skos:definition "connects an association to a qualitative term denoting the level of confidence" ;
    skos:inScheme biolink: .

biolink:has_constituent a owl:ObjectProperty ;
    rdfs:label "has constituent" ;
    rdfs:range biolink:MolecularEntity ;
    rdfs:subPropertyOf biolink:node_property ;
    skos:definition "one or more molecular entities within a chemical mixture" ;
    skos:inScheme biolink: .

biolink:has_contraindication a owl:ObjectProperty ;
    rdfs:label "has contraindication" ;
    rdfs:domain biolink:BiologicalEntity ;
    rdfs:range biolink:ChemicalOrDrugOrTreatment ;
    rdfs:subPropertyOf biolink:related_to_at_instance_level ;
    owl:inverseOf biolink:contraindicated_in ;
    skos:inScheme biolink: .

biolink:has_editor a owl:ObjectProperty ;
    rdfs:label "has editor" ;
    rdfs:domain biolink:Publication ;
    rdfs:range biolink:Agent ;
    rdfs:subPropertyOf biolink:has_contributor ;
    owl:inverseOf biolink:editor ;
    skos:inScheme biolink: .

biolink:has_frameshift_variant a owl:ObjectProperty ;
    rdfs:label "has frameshift variant" ;
    rdfs:domain biolink:GenomicEntity ;
    rdfs:range biolink:SequenceVariant ;
    rdfs:subPropertyOf biolink:has_sequence_variant ;
    owl:inverseOf biolink:is_frameshift_variant_of ;
    skos:altLabel "splice acceptor variant",
        "splice donor variant",
        "splice region variant" ;
    skos:inScheme biolink: .

biolink:has_gene_product a owl:ObjectProperty ;
    rdfs:label "has gene product" ;
    rdfs:domain biolink:Gene ;
    rdfs:range biolink:GeneProductMixin ;
    rdfs:subPropertyOf biolink:related_to_at_instance_level ;
    owl:inverseOf biolink:gene_product_of ;
    skos:closeMatch <http://purl.obolibrary.org/obo/PR_has_gene_template> ;
    skos:definition "holds between a gene and a transcribed and/or translated product generated from it" ;
    skos:exactMatch <http://purl.obolibrary.org/obo/NCIT_gene_encodes_gene_product>,
        RO:0002205,
        WIKIDATA_PROPERTY:P688 ;
    skos:inScheme biolink: ;
    skos:narrowMatch <http://purl.obolibrary.org/obo/NCIT_R178> .

biolink:has_missense_variant a owl:ObjectProperty ;
    rdfs:label "has missense variant" ;
    rdfs:domain biolink:GenomicEntity ;
    rdfs:range biolink:SequenceVariant ;
    rdfs:subPropertyOf biolink:has_sequence_variant ;
    owl:inverseOf biolink:is_missense_variant_of ;
    skos:inScheme biolink: .

biolink:has_nearby_variant a owl:ObjectProperty ;
    rdfs:label "has nearby variant" ;
    rdfs:domain biolink:GenomicEntity ;
    rdfs:range biolink:SequenceVariant ;
    rdfs:subPropertyOf biolink:has_sequence_variant ;
    owl:inverseOf biolink:is_nearby_variant_of ;
    skos:altLabel "3 prime UTR variant",
        "5 prime UTR premature start codon gain variant",
        "5 prime UTR variant",
        "intron variant",
        "non coding transcript exon variant" ;
    skos:inScheme biolink: .

biolink:has_negative_upstream_actor a owl:ObjectProperty ;
    rdfs:label "has negative upstream actor" ;
    rdfs:domain biolink:BiologicalProcess ;
    rdfs:range biolink:GeneOrGeneProduct ;
    rdfs:subPropertyOf biolink:has_upstream_actor ;
    owl:inverseOf biolink:acts_upstream_of_negative_effect ;
    skos:inScheme biolink: .

biolink:has_negative_upstream_or_within_actor a owl:ObjectProperty ;
    rdfs:label "has negative upstream or within actor" ;
    rdfs:domain biolink:BiologicalProcess ;
    rdfs:range biolink:GeneOrGeneProduct ;
    rdfs:subPropertyOf biolink:has_upstream_or_within_actor ;
    owl:inverseOf biolink:acts_upstream_of_or_within_negative_effect ;
    skos:inScheme biolink: .

biolink:has_non_coding_variant a owl:ObjectProperty ;
    rdfs:label "has non coding variant" ;
    rdfs:domain biolink:GenomicEntity ;
    rdfs:range biolink:SequenceVariant ;
    rdfs:subPropertyOf biolink:has_sequence_variant ;
    owl:inverseOf biolink:is_non_coding_variant_of ;
    skos:inScheme biolink: .

biolink:has_nonsense_variant a owl:ObjectProperty ;
    rdfs:label "has nonsense variant" ;
    rdfs:domain biolink:GenomicEntity ;
    rdfs:range biolink:SequenceVariant ;
    rdfs:subPropertyOf biolink:has_sequence_variant ;
    owl:inverseOf biolink:is_nonsense_variant_of ;
    skos:inScheme biolink: .

biolink:has_positive_upstream_actor a owl:ObjectProperty ;
    rdfs:label "has positive upstream actor" ;
    rdfs:domain biolink:BiologicalProcess ;
    rdfs:range biolink:GeneOrGeneProduct ;
    rdfs:subPropertyOf biolink:has_upstream_actor ;
    owl:inverseOf biolink:acts_upstream_of_positive_effect ;
    skos:inScheme biolink: .

biolink:has_positive_upstream_or_within_actor a owl:ObjectProperty ;
    rdfs:label "has positive upstream or within actor" ;
    rdfs:domain biolink:BiologicalProcess ;
    rdfs:range biolink:GeneOrGeneProduct ;
    rdfs:subPropertyOf biolink:has_upstream_or_within_actor ;
    owl:inverseOf biolink:acts_upstream_of_or_within_positive_effect ;
    skos:inScheme biolink: .

biolink:has_preventative_intervention a owl:ObjectProperty ;
    rdfs:label "has preventative intervention" ;
    rdfs:domain biolink:DiseaseOrPhenotypicFeature ;
    rdfs:range biolink:ChemicalOrDrugOrTreatment ;
    rdfs:subPropertyOf biolink:likelihood_affected_by ;
    owl:inverseOf biolink:preventative_for_condition ;
    skos:inScheme biolink: .

biolink:has_provider a owl:ObjectProperty ;
    rdfs:label "has provider" ;
    rdfs:domain biolink:InformationContentEntity ;
    rdfs:range biolink:Agent ;
    rdfs:subPropertyOf biolink:has_contributor ;
    owl:inverseOf biolink:provider ;
    skos:inScheme biolink: .

biolink:has_publisher a owl:ObjectProperty ;
    rdfs:label "has publisher" ;
    rdfs:domain biolink:Publication ;
    rdfs:range biolink:Agent ;
    rdfs:subPropertyOf biolink:has_contributor ;
    owl:inverseOf biolink:publisher ;
    skos:inScheme biolink: .

biolink:has_receptor a owl:ObjectProperty ;
    rdfs:label "has receptor" ;
    rdfs:domain biolink:ExposureEvent ;
    rdfs:range biolink:OrganismalEntity ;
    rdfs:subPropertyOf biolink:node_property ;
    skos:definition "An entity that interacts with an exposure stimulus during an exposure event." ;
    skos:exactMatch ExO:0000001 ;
    skos:inScheme biolink: .

biolink:has_route a owl:DatatypeProperty ;
    rdfs:label "has route" ;
    rdfs:domain biolink:ExposureEvent ;
    rdfs:subPropertyOf biolink:node_property ;
    skos:definition "the process that results in the stressor coming into direct contact with the receptor" ;
    skos:exactMatch ExO:0000055 ;
    skos:inScheme biolink: ;
    skos:narrowMatch LOINC:has_pharmaceutical_route,
        <http://purl.obolibrary.org/obo/SNOMED_has_dose_form_intended_site>,
        <http://purl.obolibrary.org/obo/SNOMED_has_route_of_administration> .

biolink:has_splice_site_variant a owl:ObjectProperty ;
    rdfs:label "has splice site variant" ;
    rdfs:domain biolink:GenomicEntity ;
    rdfs:range biolink:SequenceVariant ;
    rdfs:subPropertyOf biolink:has_sequence_variant ;
    owl:inverseOf biolink:is_splice_site_variant_of ;
    skos:altLabel "downstream gene variant",
        "upstream gene variant" ;
    skos:inScheme biolink: .

biolink:has_stressor a owl:DatatypeProperty ;
    rdfs:label "has stressor" ;
    rdfs:domain biolink:ExposureEvent ;
    rdfs:subPropertyOf biolink:node_property ;
    skos:altLabel "has stimulus" ;
    skos:definition "An agent, stimulus, activity, or event that causes stress or tension on an organism and interacts with an exposure_receptor during an exposure event." ;
    skos:exactMatch ExO:0000000 ;
    skos:inScheme biolink: .

biolink:has_synonymous_variant a owl:ObjectProperty ;
    rdfs:label "has synonymous variant" ;
    rdfs:domain biolink:GenomicEntity ;
    rdfs:range biolink:SequenceVariant ;
    rdfs:subPropertyOf biolink:has_sequence_variant ;
    owl:inverseOf biolink:is_synonymous_variant_of ;
    skos:altLabel "stop gained" ;
    skos:inScheme biolink: .

biolink:has_target a owl:ObjectProperty ;
    rdfs:label "has target" ;
    rdfs:domain biolink:Disease ;
    rdfs:range biolink:Gene ;
    rdfs:subPropertyOf biolink:related_to_at_instance_level ;
    owl:inverseOf biolink:target_for ;
    skos:inScheme biolink: .

biolink:has_topic a owl:ObjectProperty ;
    rdfs:label "has topic" ;
    rdfs:range biolink:OntologyClass ;
    rdfs:subPropertyOf biolink:node_property ;
    skos:altLabel "descriptors",
        "topic" ;
    skos:definition "Connects a node to a vocabulary term or ontology class that describes some aspect of the entity. In general specific characterization is preferred. See https://github.com/biolink/biolink-model/issues/238" ;
    skos:exactMatch foaf:topic ;
    skos:inScheme biolink: .

biolink:in_cell_population_with a owl:ObjectProperty,
        owl:SymmetricProperty ;
    rdfs:label "in cell population with" ;
    rdfs:domain biolink:GeneOrGeneProduct ;
    rdfs:range biolink:GeneOrGeneProduct ;
    rdfs:subPropertyOf biolink:coexists_with ;
    skos:definition "holds between two genes or gene products that are expressed in the same cell type or population" ;
    skos:inScheme biolink: ;
    biolink:canonical_predicate true .

biolink:in_complex_with a owl:ObjectProperty,
        owl:SymmetricProperty ;
    rdfs:label "in complex with" ;
    rdfs:domain biolink:GeneOrGeneProduct ;
    rdfs:range biolink:GeneOrGeneProduct ;
    rdfs:subPropertyOf biolink:coexists_with ;
    skos:broadMatch SIO:010285 ;
    skos:definition "holds between two genes or gene products that are part of (or code for products that are part of) in the same macromolecular complex" ;
    skos:inScheme biolink: ;
    skos:relatedMatch SIO:010497 ;
    biolink:canonical_predicate true .

biolink:in_linkage_disequilibrium_with a owl:DatatypeProperty,
        owl:SymmetricProperty ;
    rdfs:label "in linkage disequilibrium with" ;
    rdfs:subPropertyOf biolink:related_to_at_instance_level ;
    skos:definition "holds between two sequence variants, the presence of which are correlated in a population" ;
    skos:exactMatch <http://purl.obolibrary.org/obo/NCIT_C16798> ;
    skos:inScheme biolink: ;
    biolink:canonical_predicate true .

biolink:in_pathway_with a owl:ObjectProperty,
        owl:SymmetricProperty ;
    rdfs:label "in pathway with" ;
    rdfs:domain biolink:GeneOrGeneProduct ;
    rdfs:range biolink:GeneOrGeneProduct ;
    rdfs:subPropertyOf biolink:coexists_with ;
    skos:definition "holds between two genes or gene products that are part of in the same biological pathway" ;
    skos:inScheme biolink: ;
    skos:relatedMatch SIO:010532 ;
    biolink:canonical_predicate true .

biolink:increased_amount_of a owl:DatatypeProperty ;
    rdfs:label "increased amount of" ;
    rdfs:subPropertyOf biolink:related_to_at_instance_level ;
    owl:inverseOf biolink:has_increased_amount ;
    skos:inScheme biolink: .

biolink:increased_likelihood_associated_with a owl:DatatypeProperty ;
    rdfs:label "increased likelihood associated with" ;
    rdfs:subPropertyOf biolink:likelihood_associated_with ;
    owl:inverseOf biolink:associated_with_increased_likelihood_of ;
    skos:inScheme biolink: .

biolink:indirectly_physically_interacts_with a owl:DatatypeProperty,
        owl:SymmetricProperty ;
    rdfs:label "indirectly physically interacts with" ;
    rdfs:subPropertyOf biolink:physically_interacts_with ;
    skos:definition "Holds between two entities that physically interact by way of one or more intermediary entities, rather than through direct physical contact." ;
    skos:inScheme biolink: ;
    biolink:canonical_predicate true .

biolink:intact_confidence_value a owl:DatatypeProperty ;
    rdfs:label "intact confidence value" ;
    skos:altLabel "intact interaction score",
        "intact miscore" ;
    skos:definition "A score defined by MI / IntAct that represents the degree of confidence in the existence of a particular interaction by assessing the annotation of that specific interaction in a standards-compliant dataset. The score given to an interaction will increase as the number of experimental evidences supporting that interaction increases. Experimental evidences contribute more highly to the final score than evidences derived by predictive algorithms or literature text-mining methods. Range is 0-1, with higher scores indicated more confidence. See here for details: https://www.ebi.ac.uk/intact/documentation/user-guide#interaction_scoring." ;
    skos:inScheme <https://w3id.org/biolink/biolink-model/attributes> .

biolink:is_active_ingredient_of a owl:ObjectProperty ;
    rdfs:label "is active ingredient of" ;
    rdfs:domain biolink:MolecularEntity ;
    rdfs:range biolink:Drug ;
    rdfs:subPropertyOf biolink:part_of ;
    owl:inverseOf biolink:has_active_ingredient ;
    skos:definition "holds between a molecular entity and a drug, in which the former is a part of the latter, and is a biologically active component" ;
    skos:inScheme biolink: ;
    skos:mappingRelation RO:0002249 .

biolink:is_diagnosed_by a owl:ObjectProperty ;
    rdfs:label "is diagnosed by" ;
    rdfs:domain biolink:DiseaseOrPhenotypicFeature ;
    rdfs:range biolink:DiagnosticAid ;
    rdfs:subPropertyOf biolink:related_to_at_instance_level ;
    owl:inverseOf biolink:diagnoses ;
    skos:inScheme biolink: .

biolink:is_excipient_of a owl:ObjectProperty ;
    rdfs:label "is excipient of" ;
    rdfs:domain biolink:MolecularEntity ;
    rdfs:range biolink:Drug ;
    rdfs:subPropertyOf biolink:part_of ;
    owl:inverseOf biolink:has_excipient ;
    skos:definition "holds between a molecular entity and a drug in which the former is a part of the latter, and is a biologically inactive component" ;
    skos:inScheme biolink: ;
    skos:mappingRelation WIKIDATA:Q902638 .

biolink:is_metabolite_of a owl:ObjectProperty ;
    rdfs:label "is metabolite of" ;
    rdfs:domain biolink:MolecularEntity ;
    rdfs:range biolink:MolecularEntity ;
    rdfs:subPropertyOf biolink:derives_from ;
    owl:inverseOf biolink:has_metabolite ;
    skos:definition "holds between two molecular entities in which the first one is derived from the second one as a product of metabolism" ;
    skos:exactMatch <http://purl.obolibrary.org/obo/CHEBI_25212> ;
    skos:inScheme biolink: ;
    skos:note "The CHEBI ID represents a role rather than a predicate" .

biolink:is_molecular_consequence_of a owl:DatatypeProperty ;
    rdfs:label "is molecular consequence of" ;
    rdfs:domain biolink:OntologyClass ;
    rdfs:subPropertyOf biolink:related_to_at_instance_level ;
    owl:inverseOf biolink:has_molecular_consequence ;
    skos:inScheme biolink: .

biolink:is_output_of a owl:ObjectProperty ;
    rdfs:label "is output of" ;
    rdfs:domain biolink:NamedThing ;
    rdfs:range biolink:BiologicalProcessOrActivity ;
    rdfs:subPropertyOf biolink:participates_in ;
    owl:inverseOf biolink:has_output ;
    skos:exactMatch RO:0002353 ;
    skos:inScheme biolink: ;
    skos:narrowMatch RO:0002354 .

biolink:is_side_effect_of a owl:ObjectProperty ;
    rdfs:label "is side effect of" ;
    rdfs:domain biolink:DiseaseOrPhenotypicFeature ;
    rdfs:range biolink:ChemicalOrDrugOrTreatment ;
    rdfs:subPropertyOf biolink:affected_by ;
    owl:inverseOf biolink:has_side_effect ;
    skos:inScheme biolink: .

biolink:is_substrate_of a owl:ObjectProperty ;
    rdfs:label "is substrate of" ;
    rdfs:domain biolink:ChemicalEntityOrGeneOrGeneProduct ;
    rdfs:range biolink:ChemicalEntityOrGeneOrGeneProduct ;
    rdfs:subPropertyOf biolink:participates_in ;
    owl:inverseOf biolink:has_substrate ;
    skos:inScheme biolink: .

biolink:ln_ratio a owl:DatatypeProperty ;
    rdfs:label "ln ratio" ;
    rdfs:range xsd:float ;
    rdfs:subPropertyOf biolink:association_slot ;
    skos:definition "the natural log of the ratio of co-occurrence to expected" ;
    skos:inScheme biolink: .

biolink:ln_ratio_confidence_interval a owl:DatatypeProperty ;
    rdfs:label "ln ratio confidence interval" ;
    rdfs:range xsd:float ;
    rdfs:subPropertyOf biolink:association_slot ;
    skos:definition "The 99% confidence interval for the ln_ratio calculation (i.e. the range of values within which the true value has a 99% chance of falling)" ;
    skos:inScheme biolink: .

biolink:location_of_disease a owl:DatatypeProperty ;
    rdfs:label "location of disease" ;
    rdfs:subPropertyOf biolink:related_to ;
    owl:inverseOf biolink:disease_has_location ;
    skos:inScheme biolink: .

biolink:logical_interpretation a owl:ObjectProperty ;
    rdfs:label "logical interpretation" ;
    rdfs:domain biolink:Association ;
    rdfs:range biolink:LogicalInterpretationEnum ;
    rdfs:subPropertyOf biolink:association_slot ;
    skos:exactMatch os:LogicalInterpretation ;
    skos:inScheme biolink: .

biolink:mechanism_of_action a owl:DatatypeProperty ;
    rdfs:label "mechanism of action" ;
    rdfs:range xsd:boolean ;
    rdfs:subPropertyOf biolink:association_slot ;
    skos:definition "a boolean flag to indicate if the edge is part of a path or subgraph of a knowledge graph that constitutes the mechanism of action for a result." ;
    skos:exactMatch LOINC:MTHU019741,
        MI:2044,
        <http://purl.obolibrary.org/obo/NCIT_C54680> ;
    skos:inScheme biolink: .

biolink:member_of a owl:DatatypeProperty ;
    rdfs:label "member of" ;
    rdfs:subPropertyOf biolink:related_to_at_concept_level ;
    owl:inverseOf biolink:has_member ;
    skos:closeMatch skos:member ;
    skos:definition "Defines a mereological relation between a item and a collection." ;
    skos:exactMatch RO:0002350 ;
    skos:inScheme biolink: .

biolink:mentioned_by a owl:DatatypeProperty ;
    rdfs:label "mentioned by" ;
    rdfs:subPropertyOf biolink:related_to_at_instance_level ;
    owl:inverseOf biolink:mentions ;
    skos:definition "refers to is a relation between one named thing and the information content entity that it makes reference to." ;
    skos:inScheme biolink: .

biolink:missing_from a owl:DatatypeProperty ;
    rdfs:label "missing from" ;
    rdfs:subPropertyOf biolink:related_to_at_instance_level ;
    owl:inverseOf biolink:lacks_part ;
    skos:inScheme biolink: .

biolink:mode_of_inheritance_of a owl:ObjectProperty ;
    rdfs:label "mode of inheritance of" ;
    rdfs:domain biolink:GeneticInheritance ;
    rdfs:range biolink:DiseaseOrPhenotypicFeature ;
    rdfs:subPropertyOf biolink:manifestation_of ;
    owl:inverseOf biolink:has_mode_of_inheritance ;
    skos:inScheme biolink: .

biolink:models a owl:DatatypeProperty ;
    rdfs:label "models" ;
    rdfs:subPropertyOf biolink:related_to_at_instance_level ;
    owl:inverseOf biolink:model_of ;
    skos:inScheme biolink: .

biolink:models_demonstrating_benefits_for a owl:ObjectProperty ;
    rdfs:label "models demonstrating benefits for" ;
    rdfs:domain biolink:DiseaseOrPhenotypicFeature ;
    rdfs:range biolink:ChemicalOrDrugOrTreatment ;
    rdfs:subPropertyOf biolink:subject_of_treatment_application_or_study_for_treatment_by,
        biolink:tested_by_preclinical_trials_of ;
    owl:inverseOf biolink:beneficial_in_models_for ;
    skos:inScheme biolink: .

biolink:narrow_matches a owl:DatatypeProperty ;
    rdfs:label "narrow matches" ;
    skos:definition "A list of terms from different schemas or terminology systems that have a narrower meaning. Such terms often describe a more specific concept from different ontological perspectives." ;
    skos:inScheme biolink: .

biolink:negatively_correlated_with a owl:ObjectProperty,
        owl:SymmetricProperty ;
    rdfs:label "negatively correlated with" ;
    rdfs:domain biolink:NamedThing ;
    rdfs:range biolink:NamedThing ;
    rdfs:subPropertyOf biolink:correlated_with ;
    skos:definition "A relationship that holds between two concepts represented by variables for which a statistical correlation is demonstrated, wherein variable values move in opposite directions (i.e. increased in one or presence of one correlates with a decrease or absence of the other)." ;
    skos:exactMatch CTD:negative_correlation ;
    skos:inScheme biolink: ;
    biolink:canonical_predicate true ;
    biolink:opposite_of "positively correlated with" .

biolink:not_completed_by a owl:DatatypeProperty ;
    rdfs:label "not completed by" ;
    rdfs:subPropertyOf biolink:related_to_at_instance_level ;
    owl:inverseOf biolink:has_not_completed ;
    skos:inScheme biolink: .

biolink:nutrient_of a owl:ObjectProperty ;
    rdfs:label "nutrient of" ;
    rdfs:domain biolink:ChemicalEntity ;
    rdfs:range biolink:ChemicalEntity ;
    rdfs:subPropertyOf biolink:food_component_of ;
    owl:inverseOf biolink:has_nutrient ;
    skos:definition "holds between a one or more chemical entities present in food, irrespective of nutritional value (i.e. could also be a contaminant or additive)" ;
    skos:inScheme biolink: .

biolink:occurs_in_disease a owl:DatatypeProperty ;
    rdfs:label "occurs in disease" ;
    rdfs:subPropertyOf biolink:related_to_at_instance_level ;
    owl:inverseOf biolink:disease_has_basis_in ;
    skos:inScheme biolink: .

biolink:occurs_together_in_literature_with a owl:ObjectProperty,
        owl:SymmetricProperty ;
    rdfs:label "occurs together in literature with" ;
    rdfs:domain biolink:NamedThing ;
    rdfs:range biolink:NamedThing ;
    rdfs:subPropertyOf biolink:correlated_with ;
    skos:definition "holds between two entities where their co-occurrence is correlated by counts of publications in which both occur, using some threshold of occurrence as defined by the edge provider." ;
    skos:inScheme biolink: ;
    biolink:canonical_predicate true .

biolink:opposite_of a owl:DatatypeProperty,
        owl:SymmetricProperty ;
    rdfs:label "opposite of" ;
    rdfs:seeAlso <https://doi.org/10.1101/108977>,
        <https://github.com/biolink/biolink-model/issues/657> ;
    rdfs:subPropertyOf biolink:related_to_at_instance_level ;
    skos:definition "x is the opposite of y if there exists some distance metric M, and there exists no z such as M(x,z) <= M(x,y) or M(y,z) <= M(y,x). (This description is from RO. Needs to be rephrased)." ;
    skos:exactMatch RO:0002604 ;
    skos:inScheme biolink: ;
    biolink:canonical_predicate true .

biolink:orthologous_to a owl:DatatypeProperty,
        owl:SymmetricProperty ;
    rdfs:label "orthologous to" ;
    rdfs:subPropertyOf biolink:homologous_to ;
    skos:definition "a homology relationship between entities (typically genes) that diverged after a speciation event." ;
    skos:exactMatch RO:HOM0000017,
        WIKIDATA_PROPERTY:P684 ;
    skos:inScheme biolink: ;
    biolink:canonical_predicate true .

biolink:paralogous_to a owl:DatatypeProperty,
        owl:SymmetricProperty ;
    rdfs:label "paralogous to" ;
    rdfs:subPropertyOf biolink:homologous_to ;
    skos:definition "a homology relationship that holds between entities (typically genes) that diverged after a duplication event." ;
    skos:exactMatch RO:HOM0000011 ;
    skos:inScheme biolink: ;
    biolink:canonical_predicate true .

biolink:pharmacologically_interacts_with a owl:ObjectProperty,
        owl:SymmetricProperty ;
    rdfs:label "pharmacologically interacts with" ;
    rdfs:domain biolink:ChemicalEntity ;
    rdfs:range biolink:ChemicalEntity ;
    rdfs:subPropertyOf biolink:interacts_with ;
    skos:altLabel "drug drug interaction" ;
    skos:definition "holds between two pharmacologically active chemicals (typically drugs), where one alters the availability, efficacy, or toxicity of the other in the body when taken simultaneously - typically by altering how the body processes the chemical (pharmacokinetics) or how the chemical acts on the body (pharmacodynamics)." ;
    skos:inScheme biolink: ;
    biolink:canonical_predicate true .

biolink:phenotype_of a owl:ObjectProperty ;
    rdfs:label "phenotype of" ;
    rdfs:domain biolink:PhenotypicFeature ;
    rdfs:range biolink:BiologicalEntity ;
    rdfs:subPropertyOf biolink:related_to_at_instance_level ;
    owl:inverseOf biolink:has_phenotype ;
    skos:inScheme biolink: .

biolink:plasma_membrane_part_of a owl:DatatypeProperty ;
    rdfs:label "plasma membrane part of" ;
    rdfs:subPropertyOf biolink:part_of ;
    owl:inverseOf biolink:has_plasma_membrane_part ;
    skos:inScheme biolink: .

biolink:positively_correlated_with a owl:ObjectProperty,
        owl:SymmetricProperty ;
    rdfs:label "positively correlated with" ;
    rdfs:domain biolink:NamedThing ;
    rdfs:range biolink:NamedThing ;
    rdfs:subPropertyOf biolink:correlated_with ;
    skos:definition "A relationship that holds between two concepts represented by variables for which a statistical correlation is demonstrated, wherein variable values move together in the same direction (i.e. increased in one or presence of one correlates with an increase or presence of the other)." ;
    skos:exactMatch CTD:positive_correlation ;
    skos:inScheme biolink: ;
    biolink:canonical_predicate true ;
    biolink:opposite_of "negatively correlated with" .

biolink:preceded_by a owl:ObjectProperty ;
    rdfs:label "preceded by" ;
    rdfs:domain biolink:Occurrent ;
    rdfs:range biolink:Occurrent ;
    rdfs:subPropertyOf biolink:temporally_related_to ;
    owl:inverseOf biolink:precedes ;
    skos:broadMatch <http://purl.obolibrary.org/obo/GENEPIO_0001739> ;
    skos:definition "holds between two processes, where the other is completed before the one begins" ;
    skos:exactMatch <http://purl.obolibrary.org/obo/BFO_0000062> ;
    skos:inScheme biolink: ;
    skos:narrowMatch FMA:transforms_from,
        RO:0002087,
        RO:0002285 .

biolink:primarily_composed_of a owl:DatatypeProperty ;
    rdfs:label "primarily composed of" ;
    rdfs:subPropertyOf biolink:related_to ;
    owl:inverseOf biolink:composed_primarily_of ;
    skos:inScheme biolink: .

biolink:produced_by a owl:DatatypeProperty ;
    rdfs:label "produced by" ;
    rdfs:subPropertyOf biolink:related_to_at_instance_level ;
    owl:inverseOf biolink:produces ;
    skos:exactMatch RO:0003001 ;
    skos:inScheme biolink: .

biolink:reaction_balanced a owl:DatatypeProperty ;
    rdfs:label "reaction balanced" ;
    rdfs:range xsd:boolean ;
    rdfs:subPropertyOf biolink:association_slot ;
    skos:definition "Indicates whether a chemical reaction is stoichiometrically balanced, i.e. whether the conservation of atoms (and charge) holds between the reactants and the products." ;
    skos:inScheme biolink: .

biolink:regulated_by a owl:ObjectProperty ;
    rdfs:label "regulated by" ;
    rdfs:domain biolink:PhysicalEssenceOrOccurrent ;
    rdfs:range biolink:PhysicalEssenceOrOccurrent ;
    rdfs:subPropertyOf biolink:affected_by ;
    owl:inverseOf biolink:regulates ;
    skos:inScheme biolink: .

biolink:related_condition a owl:DatatypeProperty,
        owl:SymmetricProperty ;
    rdfs:label "related condition" ;
    rdfs:subPropertyOf biolink:related_to_at_instance_level ;
    skos:definition "Links a genotype or genetic variant to a condition (disease or phenotypic feature) that is associated with it." ;
    skos:exactMatch <http://purl.obolibrary.org/obo/GENO_0000790> ;
    skos:inScheme biolink: ;
    biolink:canonical_predicate true .

biolink:relation a owl:DatatypeProperty ;
    rdfs:label "relation" ;
    skos:inScheme biolink: .

biolink:relative_frequency_object a owl:DatatypeProperty ;
    rdfs:label "relative frequency object" ;
    rdfs:range xsd:string ;
    rdfs:subPropertyOf biolink:association_slot ;
    skos:definition "The frequency at which subject and object concepts co-occur in records within a dataset/cohort, relative to the frequency at which the object concept appears in these same records." ;
    skos:inScheme biolink: .

biolink:relative_frequency_object_confidence_interval a owl:DatatypeProperty ;
    rdfs:label "relative frequency object confidence interval" ;
    rdfs:range xsd:string ;
    rdfs:subPropertyOf biolink:association_slot ;
    skos:definition "The 99% confidence interval for the relative_frequency_object calculation (i.e. the range of values within which the true value has a 99% chance of falling)" ;
    skos:inScheme biolink: .

biolink:relative_frequency_subject a owl:DatatypeProperty ;
    rdfs:label "relative frequency subject" ;
    rdfs:range xsd:float ;
    rdfs:subPropertyOf biolink:association_slot ;
    skos:definition "The frequency at which subject and object concepts co-occur in records within a dataset/cohort, relative to the frequency at which the subject concept appears in these same records." ;
    skos:inScheme biolink: .

biolink:relative_frequency_subject_confidence_interval a owl:DatatypeProperty ;
    rdfs:label "relative frequency subject confidence interval" ;
    rdfs:range xsd:string ;
    rdfs:subPropertyOf biolink:association_slot ;
    skos:definition "The 99% confidence interval for the relative_frequency_subject calculation (i.e. the range of values within which the true value has a 99% chance of falling)" ;
    skos:inScheme biolink: .

biolink:resistance_associated_with a owl:ObjectProperty ;
    rdfs:label "resistance associated with" ;
    rdfs:domain biolink:ChemicalEntity ;
    rdfs:range biolink:NamedThing ;
    rdfs:subPropertyOf biolink:response_associated_with ;
    owl:inverseOf biolink:associated_with_resistance_to ;
    skos:inScheme biolink: .

biolink:retrieved_on a owl:DatatypeProperty ;
    rdfs:label "retrieved on" ;
    rdfs:domain biolink:Dataset ;
    rdfs:range xsd:date ;
    rdfs:subPropertyOf biolink:node_property ;
    skos:definition "The date on which a dataset was retrieved or harvested from its original source, following pav:retrievedOn." ;
    skos:exactMatch pav:retrievedOn ;
    skos:inScheme biolink: .

biolink:same_as a owl:DatatypeProperty,
        owl:SymmetricProperty ;
    rdfs:label "same as" ;
    rdfs:subPropertyOf biolink:exact_match ;
    skos:closeMatch owl:equivalentClass ;
    skos:definition "holds between two entities that are considered equivalent to each other" ;
    skos:exactMatch <http://purl.obolibrary.org/obo/MONDO_equivalentTo>,
        owl:sameAs,
        skos:exactMatch,
        CHEMBL.MECHANISM:equivalent_to,
        WIKIDATA_PROPERTY:P2888 ;
    skos:inScheme biolink: ;
    skos:narrowMatch <http://identifiers.org/drugbank/external-identifier> ;
    biolink:canonical_predicate true .

biolink:sensitivity_associated_with a owl:ObjectProperty ;
    rdfs:label "sensitivity associated with" ;
    rdfs:domain biolink:ChemicalEntity ;
    rdfs:range biolink:NamedThing ;
    rdfs:subPropertyOf biolink:response_associated_with ;
    owl:inverseOf biolink:associated_with_sensitivity_to ;
    skos:inScheme biolink: .

biolink:sensitivity_decreased_by a owl:ObjectProperty ;
    rdfs:label "sensitivity decreased by" ;
    rdfs:domain biolink:ChemicalEntityOrGeneOrGeneProduct ;
    rdfs:range biolink:ChemicalEntityOrGeneOrGeneProduct ;
    rdfs:subPropertyOf biolink:sensitivity_affected_by ;
    owl:inverseOf biolink:decreases_sensitivity_to ;
    skos:inScheme biolink: .

biolink:sensitivity_increased_by a owl:ObjectProperty ;
    rdfs:label "sensitivity increased by" ;
    rdfs:domain biolink:ChemicalEntityOrGeneOrGeneProduct ;
    rdfs:range biolink:ChemicalEntityOrGeneOrGeneProduct ;
    rdfs:subPropertyOf biolink:sensitivity_affected_by ;
    owl:inverseOf biolink:increases_sensitivity_to ;
    skos:inScheme biolink: .

biolink:sequence_location_of a owl:ObjectProperty ;
    rdfs:label "sequence location of" ;
    rdfs:domain biolink:NucleicAcidEntity ;
    rdfs:range biolink:NucleicAcidEntity ;
    rdfs:subPropertyOf biolink:related_to_at_instance_level ;
    owl:inverseOf biolink:has_sequence_location ;
    skos:inScheme biolink: .

biolink:sequence_variant_qualifier a owl:ObjectProperty ;
    rdfs:label "sequence variant qualifier" ;
    rdfs:range biolink:SequenceVariant ;
    rdfs:subPropertyOf biolink:association_slot ;
    skos:definition "a qualifier used in an association with the variant" ;
    skos:inScheme biolink: .

biolink:severity_qualifier a owl:ObjectProperty ;
    rdfs:label "severity qualifier" ;
    rdfs:range biolink:SeverityValue ;
    rdfs:subPropertyOf biolink:qualifier ;
    skos:definition "a qualifier used in a phenotypic association to state how severe the phenotype is in the subject" ;
    skos:inScheme biolink: .

biolink:signor_confidence_score a owl:DatatypeProperty ;
    rdfs:label "signor confidence score" ;
    rdfs:range xsd:float ;
    skos:definition "A score defined by SIGNOR Lab Diseases that reports confidence level in a curated interaction. Scores are based on four factors: number of supporting publications, occurrence in curated SIGNOR pathways, support in Reactome interaction data, co-mentions in UniProt records. Scores range 0-1, and reflect a relative measure of evidence support, not an absolute probability or statistical confidence measure. " ;
    skos:inScheme <https://w3id.org/biolink/biolink-model/attributes> .

biolink:start_coordinate a owl:DatatypeProperty ;
    rdfs:label "start coordinate" ;
    rdfs:subPropertyOf biolink:base_coordinate ;
    skos:altLabel "start" ;
    skos:closeMatch <http://biohackathon.org/resource/faldo#begin> ;
    skos:definition "The position at which the subject genomic entity starts on the chromosome or other entity to which it is located on. (ie: the start of the sequence being referenced is 1)." ;
    skos:exactMatch gff3:start ;
    skos:inScheme biolink: .

biolink:superclass_of a owl:ObjectProperty ;
    rdfs:label "superclass of" ;
    rdfs:domain biolink:OntologyClass ;
    rdfs:range biolink:OntologyClass ;
    rdfs:subPropertyOf biolink:related_to_at_concept_level ;
    owl:inverseOf biolink:subclass_of ;
    skos:definition "holds between two classes where the domain class is a super class of the range class" ;
    skos:exactMatch MESH:inverse_isa,
        RXNORM:inverse_isa,
        <http://purl.obolibrary.org/obo/GO_inverse_isa>,
        CHEMBL.MECHANISM:superset_of,
        VANDF:inverse_isa,
        WIKIDATA:Q66088480 ;
    skos:inScheme biolink: ;
    skos:narrowMatch <http://identifiers.org/umls/RB>,
        <http://purl.obolibrary.org/obo/NCIT_cdrh_parent_of>,
        <http://purl.obolibrary.org/obo/NCIT_ctcae_5_parent_of>,
        <http://purl.obolibrary.org/obo/NCIT_subset_includes_concept>,
        <http://purl.obolibrary.org/obo/OMIM_has_manifestation>,
        <http://purl.obolibrary.org/obo/SNOMED_has_basic_dose_form> .

biolink:support_graphs a owl:DatatypeProperty ;
    rdfs:label "support graphs" ;
    rdfs:subPropertyOf biolink:association_slot ;
    skos:definition "A list of knowledge graphs that support the existence of this association." ;
    skos:inScheme biolink: .

biolink:supporting_data_set a owl:DatatypeProperty ;
    rdfs:label "supporting data set" ;
    rdfs:subPropertyOf biolink:association_slot ;
    skos:definition "A set of data used as evidence to generate the knowledge expressed in an Association (e.g. through computation on, reasoning or inference over the retrieved data)." ;
    skos:inScheme biolink: .

biolink:supporting_data_source a owl:DatatypeProperty ;
    rdfs:label "supporting data source" ;
    rdfs:subPropertyOf biolink:association_slot ;
    skos:definition "An Information Resource from which data was retrieved and subsequently used as evidence to generate the knowledge expressed in an Association (e.g. through computation on, reasoning or inference over the retrieved data)." ;
    skos:editorialNote "For example, in this Feature Variable Association Edge generated by the Exposure Agent’s ICEES KP, through statistical analysis of clinical and environmental data supplied by the UNC Clinical Data Warehouse, the Edge is passed to the Ranking Agent’s ARAGORN ARA, and then on to the ARS. The retrieval path for this Edge is as follows: ARS--retrieved_from-->  ARAGORN  --retrieved_from-->   ICEES --supporting_data_from-->  UNC Data Warehouse This example illustrates how to represent the source provenance of KP-generated knowledge, including the source of data from which the knowledge was derived. The \"primary knowledge source\" for this edge is \"infores:icees-asthma\". A \"supporting data source\" for this KP- generated knowledge is \"infores:unc-cdw-health.\"  The \"aggregator knowledge source\" for this data is \"infores:aragorn-ara\"" ;
    skos:inScheme biolink: .

biolink:supporting_study_cohort a owl:DatatypeProperty ;
    rdfs:label "supporting study cohort" ;
    rdfs:range xsd:string ;
    rdfs:subPropertyOf biolink:supporting_study_metadata ;
    skos:definition "A description of a study population/cohort that was interrogated to provide evidence for the association." ;
    skos:inScheme biolink: .

biolink:supporting_study_context a owl:DatatypeProperty ;
    rdfs:label "supporting study context" ;
    rdfs:range xsd:string ;
    rdfs:subPropertyOf biolink:supporting_study_metadata ;
    skos:definition "A term or terms describing the experimental setting/context in which evidence supporting the Association was generated ('context' may be defined by many factors, including taxon, model system, tissue type, disease, etc.)." ;
    skos:inScheme biolink: .

biolink:supporting_study_date_range a owl:DatatypeProperty ;
    rdfs:label "supporting study date range" ;
    rdfs:range xsd:string ;
    rdfs:subPropertyOf biolink:supporting_study_metadata ;
    skos:definition "The date range over which data was collected in a study that provided evidence for an Association." ;
    skos:inScheme biolink: .

biolink:supporting_study_method_description a owl:DatatypeProperty ;
    rdfs:label "supporting study method description" ;
    rdfs:range xsd:anyURI ;
    rdfs:subPropertyOf biolink:supporting_study_metadata ;
    skos:definition "A uri or curie pointing to information about the methodology used to generate data supporting an Association." ;
    skos:inScheme biolink: .

biolink:supporting_study_method_types a owl:DatatypeProperty ;
    rdfs:label "supporting study method types" ;
    rdfs:range xsd:anyURI ;
    rdfs:subPropertyOf biolink:supporting_study_metadata ;
    skos:definition "Type(s) of methods that were applied in a study used to generate the information used as evidence (e.g. a type of experimental assay, or statistical calculation, or computational analysis)." ;
    skos:inScheme biolink: .

biolink:supporting_study_size a owl:DatatypeProperty ;
    rdfs:label "supporting study size" ;
    rdfs:range xsd:integer ;
    rdfs:subPropertyOf biolink:supporting_study_metadata ;
    skos:definition "The sample size used in a study that provided evidence for the association (e.g. 'n' of a cohort for a clinical study)." ;
    skos:inScheme biolink: .

biolink:systematic_synonym a owl:DatatypeProperty ;
    rdfs:label "systematic synonym" ;
    rdfs:domain biolink:NamedThing ;
    rdfs:range xsd:string ;
    rdfs:subPropertyOf biolink:node_property ;
    skos:definition "more commonly used for gene symbols in yeast" ;
    skos:inScheme biolink: .

biolink:taxon_of a owl:ObjectProperty ;
    rdfs:label "taxon of" ;
    rdfs:domain biolink:OrganismTaxon ;
    rdfs:range biolink:ThingWithTaxon ;
    rdfs:subPropertyOf biolink:related_to_at_instance_level ;
    owl:inverseOf biolink:in_taxon ;
    skos:inScheme biolink: .

biolink:temporal_interval_qualifier a owl:DatatypeProperty ;
    rdfs:label "temporal interval qualifier" ;
    rdfs:subPropertyOf biolink:temporal_context_qualifier ;
    skos:definition "a constraint of a time interval placed upon the truth value of an association." ;
    skos:inScheme biolink: .

biolink:tested_by_clinical_trials_of a owl:ObjectProperty ;
    rdfs:label "tested by clinical trials of" ;
    rdfs:domain biolink:DiseaseOrPhenotypicFeature ;
    rdfs:range biolink:ChemicalOrDrugOrTreatment ;
    rdfs:subPropertyOf biolink:subject_of_treatment_application_or_study_for_treatment_by,
        biolink:treated_in_studies_by ;
    owl:inverseOf biolink:in_clinical_trials_for ;
    skos:inScheme biolink: .

biolink:transcribed_to a owl:ObjectProperty ;
    rdfs:label "transcribed to" ;
    rdfs:domain biolink:Gene ;
    rdfs:range biolink:Transcript ;
    rdfs:subPropertyOf biolink:related_to_at_instance_level ;
    owl:inverseOf biolink:transcribed_from ;
    skos:definition "inverse of transcribed from" ;
    skos:exactMatch RO:0002511,
        SIO:010080 ;
    skos:inScheme biolink: .

biolink:translation_of a owl:ObjectProperty ;
    rdfs:label "translation of" ;
    rdfs:domain biolink:Protein ;
    rdfs:range biolink:Transcript ;
    rdfs:subPropertyOf biolink:related_to_at_instance_level ;
    owl:inverseOf biolink:translates_to ;
    skos:closeMatch RO:0002512,
        SIO:010083 ;
    skos:definition "inverse of translates to" ;
    skos:inScheme biolink: .

biolink:treatment_applications_from a owl:ObjectProperty ;
    rdfs:label "treatment applications from" ;
    rdfs:domain biolink:DiseaseOrPhenotypicFeature ;
    rdfs:range biolink:ChemicalOrDrugOrTreatment ;
    rdfs:subPropertyOf biolink:related_to_at_instance_level,
        biolink:subject_of_treatment_application_or_study_for_treatment_by ;
    owl:inverseOf biolink:applied_to_treat ;
    skos:inScheme biolink: .

biolink:url a owl:DatatypeProperty ;
    rdfs:label "url" ;
    rdfs:domain biolink:Entity ;
    rdfs:range xsd:string ;
    rdfs:subPropertyOf biolink:node_property ;
    skos:definition "This slot holds a string representation of a URL for an external resource about the node it is present on. Unlike an 'xref' that is primarily represented by a CURIE, this slot is intended to hold a full URL that can be used to directly access a resource. When linking to an external resource that cannot be represented by a unique CURIE, this slot should be used.  However, when the intent is to link to the default URI expansion of a CURIE related to the node it is present on, the xref slot should be used instead." ;
    skos:inScheme biolink: .

biolink:variant_part_of a owl:DatatypeProperty ;
    rdfs:label "variant part of" ;
    rdfs:subPropertyOf biolink:part_of ;
    owl:inverseOf biolink:has_variant_part ;
    skos:inScheme biolink: .

biolink:version a owl:DatatypeProperty ;
    rdfs:label "version" ;
    rdfs:domain biolink:Dataset ;
    rdfs:subPropertyOf biolink:node_property ;
    skos:broadMatch pav:version,
        owl:versionInfo ;
    skos:definition "A label identifying a particular release or edition of a dataset or resource, typically following a versioning scheme such as a semantic version string or a release date." ;
    skos:inScheme biolink: .

biolink:version_of a owl:ObjectProperty ;
    rdfs:label "version of" ;
    rdfs:domain biolink:DatasetVersion ;
    rdfs:range biolink:DatasetSummary ;
    rdfs:subPropertyOf biolink:node_property ;
    skos:definition "Links a dataset version to the dataset summary of which it is a version, edition, or adaptation." ;
    skos:exactMatch dct:isVersionOf ;
    skos:inScheme biolink: .

biolink:was_tested_for_effect_of a owl:ObjectProperty ;
    rdfs:label "was tested for effect of" ;
    rdfs:domain biolink:NamedThing ;
    rdfs:range biolink:NamedThing ;
    rdfs:subPropertyOf biolink:related_to_at_instance_level ;
    owl:inverseOf biolink:was_tested_for_effect_on ;
    skos:inScheme biolink: .

biolink:xenologous_to a owl:DatatypeProperty,
        owl:SymmetricProperty ;
    rdfs:label "xenologous to" ;
    rdfs:subPropertyOf biolink:homologous_to ;
    skos:definition "a homology relationship characterized by an interspecies (horizontal) transfer since the common ancestor." ;
    skos:exactMatch RO:HOM0000018 ;
    skos:inScheme biolink: ;
    biolink:canonical_predicate true .

biolink:Annotation a owl:Class ;
    rdfs:label "annotation" ;
    rdfs:subClassOf biolink:QuantityValue,
        linkml:ClassDefinition ;
    skos:definition "Biolink Model root class for entity annotations." ;
    skos:inScheme biolink: .

<https://w3id.org/biolink/vocab/ChemicalEntityDerivativeEnum#metabolite> a owl:Class ;
    rdfs:label "metabolite" ;
    rdfs:subClassOf biolink:ChemicalEntityDerivativeEnum,
        linkml:PermissibleValue .

biolink:ChemicalToEntityAssociationMixin a owl:Class ;
    rdfs:label "chemical to entity association mixin" ;
    rdfs:subClassOf biolink:ChemicalEntityToEntityAssociationMixin ;
    skos:definition "An interaction between a chemical entity and another entity" ;
    skos:inScheme biolink: .

biolink:EntityToFeatureOrGeneQualifiersMixin a owl:Class ;
    rdfs:label "entity to feature or gene qualifiers mixin" ;
    rdfs:subClassOf biolink:FrequencyQualifierMixin ;
    skos:definition "Qualifiers for entity to gene associations." ;
    skos:inScheme biolink: .

biolink:EntityToFeatureOrVariantQualifiersMixin a owl:Class ;
    rdfs:label "entity to feature or variant qualifiers mixin" ;
    rdfs:subClassOf biolink:FrequencyQualifierMixin ;
    skos:definition "Qualifiers for entity to variant associations." ;
    skos:inScheme biolink: .

biolink:PathognomonicityQuantifier a owl:Class ;
    rdfs:label "pathognomonicity quantifier" ;
    rdfs:subClassOf biolink:SpecificityQuantifier ;
    skos:definition "A relationship quantifier between a variant or symptom and a disease, which is high when the presence of the feature implies the existence of the disease" ;
    skos:inScheme biolink: .

biolink:SensitivityQuantifier a owl:Class ;
    rdfs:label "sensitivity quantifier" ;
    rdfs:subClassOf biolink:RelationshipQuantifier ;
    skos:definition "A relationship quantifier that measures the sensitivity of a relationship, such as the proportion of true positives correctly identified in a diagnostic or association context." ;
    skos:inScheme biolink: .

biolink:active_in a owl:ObjectProperty ;
    rdfs:label "active in" ;
    rdfs:domain biolink:GeneOrGeneProduct ;
    rdfs:range biolink:CellularComponent ;
    rdfs:subPropertyOf biolink:located_in ;
    skos:definition "Holds between a gene or gene product and a cellular component in which it carries out its molecular function." ;
    skos:exactMatch RO:0002432 ;
    skos:inScheme biolink: ;
    biolink:canonical_predicate true .

biolink:actively_involves a owl:ObjectProperty ;
    rdfs:label "actively involves" ;
    rdfs:domain biolink:BiologicalProcessOrActivity ;
    rdfs:range biolink:NamedThing ;
    rdfs:subPropertyOf biolink:has_participant ;
    owl:inverseOf biolink:actively_involved_in ;
    skos:inScheme biolink: .

biolink:acts_upstream_of_negative_effect a owl:ObjectProperty ;
    rdfs:label "acts upstream of negative effect" ;
    rdfs:domain biolink:GeneOrGeneProduct ;
    rdfs:range biolink:BiologicalProcess ;
    rdfs:subPropertyOf biolink:acts_upstream_of ;
    skos:definition "Holds between a gene or gene product and a biological process where the molecular function of the gene product is upstream of and has a negative (inhibiting or decreasing) effect on the execution of the process." ;
    skos:exactMatch RO:0004035 ;
    skos:inScheme biolink: ;
    biolink:canonical_predicate true .

biolink:acts_upstream_of_or_within_negative_effect a owl:ObjectProperty ;
    rdfs:label "acts upstream of or within negative effect" ;
    rdfs:domain biolink:GeneOrGeneProduct ;
    rdfs:range biolink:BiologicalProcess ;
    rdfs:subPropertyOf biolink:acts_upstream_of_or_within ;
    skos:definition "Holds between a gene or gene product and a biological process when the gene product acts upstream of or within the process with a negative (inhibiting or decreasing) effect on its execution. Corresponds to RO:0004033." ;
    skos:exactMatch RO:0004033 ;
    skos:inScheme biolink: ;
    biolink:canonical_predicate true .

biolink:acts_upstream_of_or_within_positive_effect a owl:ObjectProperty ;
    rdfs:label "acts upstream of or within positive effect" ;
    rdfs:domain biolink:GeneOrGeneProduct ;
    rdfs:range biolink:BiologicalProcess ;
    rdfs:subPropertyOf biolink:acts_upstream_of_or_within ;
    skos:definition "Holds between a gene or gene product and a biological process when the gene product acts upstream of or within the process with a positive (activating or increasing) effect on its execution. Corresponds to RO:0004032." ;
    skos:exactMatch RO:0004032 ;
    skos:inScheme biolink: ;
    biolink:canonical_predicate true .

biolink:acts_upstream_of_positive_effect a owl:ObjectProperty ;
    rdfs:label "acts upstream of positive effect" ;
    rdfs:domain biolink:GeneOrGeneProduct ;
    rdfs:range biolink:BiologicalProcess ;
    rdfs:subPropertyOf biolink:acts_upstream_of ;
    skos:definition "Holds between a gene or gene product and a biological process where the molecular function of the gene product is upstream of and has a positive (activating or increasing) effect on the execution of the process." ;
    skos:exactMatch RO:0004034 ;
    skos:inScheme biolink: ;
    biolink:canonical_predicate true .

biolink:ameliorates_condition a owl:ObjectProperty ;
    rdfs:label "ameliorates condition" ;
    rdfs:domain biolink:ChemicalOrDrugOrTreatment ;
    rdfs:range biolink:DiseaseOrPhenotypicFeature ;
    rdfs:subPropertyOf biolink:affects,
        biolink:treats ;
    skos:altLabel "ameliorates",
        "beneficial for condition",
        "therapeutic for condition" ;
    skos:definition "Holds between an entity and an existing medical condition (disease or phenotypic feature) where the entity is able to ameliorate symptoms, stabilize progression, or cure the condition." ;
    skos:editorialNote "This predicate describes a narrower view of 'treats' - that covers interventions that are beneficial for existing disease, and excludes interventions that prevent/reduce risk of developing a condition in the future." ;
    skos:exactMatch RO:0003307 ;
    skos:inScheme biolink: ;
    biolink:canonical_predicate true ;
    biolink:opposite_of "exacerbates condition" .

biolink:applied_to_treat a owl:ObjectProperty ;
    rdfs:label "applied to treat" ;
    rdfs:domain biolink:ChemicalOrDrugOrTreatment ;
    rdfs:range biolink:DiseaseOrPhenotypicFeature ;
    rdfs:subPropertyOf biolink:related_to_at_instance_level,
        biolink:treats_or_applied_or_studied_to_treat ;
    skos:altLabel "administered to treat",
        "given to treat",
        "used to treat" ;
    skos:definition "Holds between an  substance, procedure, or activity and a medical condition, and reports that the  substance, procedure, or activity was actually taken by one or more patients with the intent of treating the condition." ;
    skos:editorialNote "This predicate is used simply to report observations of use in the real world, and is agnostic to whether the treatment is approved for or might be effective in treating the condition. The treatment could be taken by a patient on their own accord or prescribed by a clinician, as an off-label or an approved intervention. In practice, it would be used to represent records/statements from patient self-reporting sources like FAERS / AEOLUS where patients directly report the condition for which they took a drug, or statements from a database cataloging instances of off-label prescription of drugs for specific conditions." ;
    skos:inScheme biolink: ;
    biolink:canonical_predicate true .

biolink:associated_with_decreased_likelihood_of a owl:DatatypeProperty ;
    rdfs:label "associated with decreased likelihood of" ;
    rdfs:subPropertyOf biolink:associated_with_likelihood_of ;
    skos:definition "Expresses a relationship between two named things where the relationship is typically generated statistically and the state or fact of something is less probable." ;
    skos:inScheme biolink: ;
    biolink:canonical_predicate true .

biolink:associated_with_increased_likelihood_of a owl:DatatypeProperty ;
    rdfs:label "associated with increased likelihood of" ;
    rdfs:subPropertyOf biolink:associated_with_likelihood_of ;
    skos:definition "Expresses a relationship between two named things where the relationship is typically generated statistically and the state or fact of something is more probable." ;
    skos:inScheme biolink: ;
    biolink:canonical_predicate true .

biolink:associated_with_resistance_to a owl:ObjectProperty ;
    rdfs:label "associated with resistance to" ;
    rdfs:domain biolink:NamedThing ;
    rdfs:range biolink:ChemicalEntity ;
    rdfs:subPropertyOf biolink:associated_with_response_to ;
    skos:definition "A relation that holds between a named thing and a chemical that specifies that the change in the named thing is found to be associated with the degree of resistance to treatment by the chemical." ;
    skos:inScheme biolink: ;
    biolink:canonical_predicate true .

biolink:associated_with_sensitivity_to a owl:ObjectProperty ;
    rdfs:label "associated with sensitivity to" ;
    rdfs:domain biolink:NamedThing ;
    rdfs:range biolink:ChemicalEntity ;
    rdfs:subPropertyOf biolink:associated_with_response_to ;
    skos:broadMatch <http://purl.obolibrary.org/obo/PATO_0000085> ;
    skos:definition "A relation that holds between a named thing and a chemical that specifies that the change in the named thing is found to be associated with the degree of sensitivity to treatment by the chemical." ;
    skos:inScheme biolink: ;
    skos:narrowMatch SNOMEDCT:418038007 ;
    biolink:canonical_predicate true .

biolink:author a owl:ObjectProperty ;
    rdfs:label "author" ;
    rdfs:domain biolink:Agent ;
    rdfs:range biolink:Publication ;
    rdfs:subPropertyOf biolink:contributor ;
    skos:definition "an instance of one (co-)creator primarily responsible for a written work" ;
    skos:exactMatch dct:creator,
        WIKIDATA_PROPERTY:P50 ;
    skos:inScheme biolink: .

biolink:beneficial_in_models_for a owl:ObjectProperty ;
    rdfs:label "beneficial in models for" ;
    rdfs:domain biolink:ChemicalOrDrugOrTreatment ;
    rdfs:range biolink:DiseaseOrPhenotypicFeature ;
    rdfs:subPropertyOf biolink:in_preclinical_trials_for,
        biolink:treats_or_applied_or_studied_to_treat ;
    skos:definition "Holds between an  substance, procedure, or activity and a medical condition, and reports that the substance, procedure, or activity has been shown to be effective in alleviating, preventing, or delaying symptoms/ phenotypes associated with a disease, in a model system for that disease (e.g. a mouse, fly, cell line, etc)." ;
    skos:editorialNote "This predicate would be used to represent Model Organism Database (MOD) records reporting that an intervention alleviated phenotypes associated with a human disease in a model organism designated as a model of that disease. (e.g. a ZFIN record reporting that treatment with Braf Inhibitors reduced the abnormal brain cell proliferation phenotype of zebrafish used to model the human disease Kabuki Syndrome) ." ;
    skos:inScheme biolink: ;
    biolink:canonical_predicate true .

biolink:biomarker_for a owl:ObjectProperty ;
    rdfs:label "biomarker for" ;
    rdfs:domain biolink:ChemicalEntityOrGeneOrGeneProduct ;
    rdfs:range biolink:DiseaseOrPhenotypicFeature ;
    rdfs:subPropertyOf biolink:correlated_with ;
    skos:broadMatch RO:0002607 ;
    skos:definition "holds between a measurable chemical entity and a disease or phenotypic feature, where the entity is used as an indicator of the presence or state of the disease or feature." ;
    skos:exactMatch <http://purl.obolibrary.org/obo/NCIT_R39> ;
    skos:inScheme biolink: ;
    skos:narrowMatch <http://purl.obolibrary.org/obo/NCIT_R47>,
        <http://purl.obolibrary.org/obo/NCIT_genetic_biomarker_related_to>,
        <http://purl.obolibrary.org/obo/NCIT_is_molecular_abnormality_of_disease>,
        ORDO:Orphanet_465410 ;
    biolink:canonical_predicate true .

biolink:capable_of a owl:ObjectProperty ;
    rdfs:label "capable of" ;
    rdfs:domain biolink:NamedThing ;
    rdfs:range biolink:Occurrent ;
    rdfs:subPropertyOf biolink:actively_involved_in ;
    skos:definition "holds between a physical entity and process or function, where the continuant alone has the ability to carry out the process or function." ;
    skos:exactMatch RO:0002215 ;
    skos:inScheme biolink: ;
    skos:narrowMatch <http://purl.obolibrary.org/obo/NCIT_R52>,
        RO:0002500 ;
    biolink:canonical_predicate true .

biolink:catalyzes a owl:DatatypeProperty ;
    rdfs:label "catalyzes" ;
    rdfs:subPropertyOf biolink:participates_in ;
    skos:definition "Holds between a macromolecular machine (typically an enzyme or ribozyme) and a biochemical reaction or process whose rate it accelerates, without itself being consumed, by lowering the activation energy." ;
    skos:exactMatch RO:0002327 ;
    skos:inScheme biolink: ;
    biolink:canonical_predicate true .

biolink:causes a owl:DatatypeProperty ;
    rdfs:label "causes" ;
    rdfs:subPropertyOf biolink:contributes_to ;
    skos:broadMatch RO:0002410,
        RO:0002506 ;
    skos:definition "holds between two entities where the occurrence, existence, or activity of one causes the occurrence or generation of the other" ;
    skos:exactMatch RO:0003303,
        <http://purl.obolibrary.org/obo/SNOMED_cause_of>,
        SEMMEDDB:CAUSES,
        WIKIDATA_PROPERTY:P1542 ;
    skos:inScheme biolink: ;
    skos:narrowMatch <http://identifiers.org/umls/has_physiologic_effect>,
        GOREL:0000040,
        <http://purl.obolibrary.org/obo/MONDO_disease_causes_feature>,
        <http://purl.obolibrary.org/obo/MONDO_disease_triggers>,
        <http://purl.obolibrary.org/obo/NCIT_allele_has_abnormality>,
        <http://purl.obolibrary.org/obo/NCIT_biological_process_has_result_biological_process>,
        <http://purl.obolibrary.org/obo/NCIT_chemical_or_drug_has_physiologic_effect>,
        <http://purl.obolibrary.org/obo/NCIT_chemical_or_drug_initiates_biological_process>,
        <http://purl.obolibrary.org/obo/NCIT_chromosome_mapped_to_disease>,
        <http://purl.obolibrary.org/obo/NCIT_disease_has_normal_tissue_origin>,
        <http://purl.obolibrary.org/obo/NCIT_process_initiates_biological_process>,
        RO:0002256,
        RO:0002315,
        RO:0002507,
        RO:0002509,
        RO:0004001,
        <http://purl.obolibrary.org/obo/SNOMED_causative_agent_of>,
        <http://purl.obolibrary.org/obo/SNOMED_has_realization>,
        NBO-PROPERTY:in_response_to,
        ORDO:Orphanet_317343,
        ORDO:Orphanet_317344,
        ORDO:Orphanet_317346,
        ORDO:Orphanet_410295,
        ORDO:Orphanet_410296 ;
    biolink:canonical_predicate true .

biolink:close_match a owl:DatatypeProperty,
        owl:SymmetricProperty ;
    rdfs:label "close match" ;
    rdfs:subPropertyOf biolink:related_to_at_concept_level ;
    skos:definition "a list of terms from different schemas or terminology systems that have a semantically similar but not strictly equivalent, broader, or narrower meaning. Such terms often describe the same general concept from different ontological perspectives." ;
    skos:exactMatch skos:closeMatch,
        SEMMEDDB:same_as ;
    skos:inScheme biolink: ;
    skos:narrowMatch <http://identifiers.org/meddra/classified_as>,
        <http://identifiers.org/umls/SY>,
        RXNORM:has_quantified_form,
        <http://purl.obolibrary.org/obo/CHEBI_is_enantiomer_of>,
        <http://purl.obolibrary.org/obo/CHEBI_is_tautomer_of>,
        OIO:hasDbXref ;
    biolink:canonical_predicate true .

biolink:composed_primarily_of a owl:DatatypeProperty ;
    rdfs:label "composed primarily of" ;
    rdfs:subPropertyOf biolink:related_to ;
    skos:definition "x composed_primarily_of_y if:more than half of the mass of x is made from parts of y." ;
    skos:exactMatch RO:0002473 ;
    skos:inScheme biolink: ;
    biolink:canonical_predicate true .

biolink:consumes a owl:ObjectProperty ;
    rdfs:label "consumes" ;
    rdfs:domain biolink:NamedThing ;
    rdfs:range biolink:NamedThing ;
    rdfs:subPropertyOf biolink:has_input ;
    skos:definition "Holds between a process and an entity that is taken in and depleted by the process; for example a metabolite consumed in a biochemical reaction." ;
    skos:inScheme biolink: ;
    skos:narrowMatch RO:0004009 ;
    biolink:canonical_predicate true .

biolink:contraindicated_in a owl:ObjectProperty ;
    rdfs:label "contraindicated in" ;
    rdfs:domain biolink:ChemicalOrDrugOrTreatment ;
    rdfs:range biolink:BiologicalEntity ;
    rdfs:subPropertyOf biolink:related_to_at_instance_level ;
    skos:definition "Holds between a substance, procedure, or activity and a medical condition or circumstance, where an authority has established that the substance, procedure, or activity should not be applied as an intervention in patients with the condition or circumstance because it can result in detrimental outcomes." ;
    skos:editorialNote "This predicate relates the intervention with a specific disease, phenotype, or other medical circumstance that puts patients at high risk for detrimental outcomes.  This may be a different condition from the one that the drug would be used to treat (e.g. pseudoephedrine is contraindicated in people with high-blood pressure as a treatment for nasal congestion), a biological state (e.g. isotretinoin is contraindicated in people who are pregnant as a treatment for acne), or being on a different medication (e.g. aspirin is contraindicated in people taking warfarin as a preventative treatment for stroke)." ;
    skos:exactMatch <http://purl.obolibrary.org/obo/NCIT_C37933> ;
    skos:inScheme biolink: ;
    biolink:canonical_predicate true ;
    biolink:opposite_of "treats" .

biolink:contribution_from a owl:DatatypeProperty ;
    rdfs:label "contribution from" ;
    rdfs:subPropertyOf biolink:related_to_at_instance_level ;
    owl:inverseOf biolink:contributes_to ;
    skos:inScheme biolink: .

biolink:dataset_count a owl:DatatypeProperty ;
    rdfs:label "dataset count" ;
    rdfs:range xsd:integer ;
    rdfs:subPropertyOf biolink:association_slot ;
    skos:definition "The total number of instances in a dataset/cohort." ;
    skos:inScheme biolink: .

biolink:decreases_amount_or_activity_of a owl:DatatypeProperty ;
    rdfs:label "decreases amount or activity of" ;
    rdfs:subPropertyOf biolink:related_to_at_instance_level ;
    skos:definition "A grouping mixin to help with searching for all the predicates that decrease the amount or activity of the object." ;
    skos:inScheme biolink: .

biolink:decreases_sensitivity_to a owl:ObjectProperty ;
    rdfs:label "decreases sensitivity to" ;
    rdfs:domain biolink:ChemicalEntityOrGeneOrGeneProduct ;
    rdfs:range biolink:ChemicalEntityOrGeneOrGeneProduct ;
    rdfs:subPropertyOf biolink:affects_sensitivity_to ;
    skos:definition "holds between two chemical entities or genes or gene products where the action or effect of one decreases the susceptibility/sensitivity of a biological entity or system  to the other" ;
    skos:exactMatch CTD:decreases_response_to ;
    skos:inScheme biolink: ;
    skos:narrowMatch CTD:decreases_response_to_substance ;
    biolink:canonical_predicate true ;
    biolink:opposite_of "increases sensitivity to" .

biolink:derives_into a owl:DatatypeProperty ;
    rdfs:label "derives into" ;
    rdfs:subPropertyOf biolink:related_to_at_instance_level ;
    owl:inverseOf biolink:derives_from ;
    skos:altLabel "is normal cell origin of disease",
        "may be normal cell origin of disease" ;
    skos:definition "holds between two distinct material entities, the old entity and the new entity, in which the new entity begins to exist when the old entity ceases to exist, and the new entity inherits the significant portion of the matter of the old entity" ;
    skos:exactMatch FMA:derives,
        RO:0001001,
        SEMMEDDB:CONVERTS_TO ;
    skos:inScheme biolink: .

biolink:develops_from a owl:DatatypeProperty ;
    rdfs:label "develops from" ;
    rdfs:subPropertyOf biolink:related_to_at_instance_level ;
    skos:closeMatch FMA:develops_into,
        RO:0002203 ;
    skos:definition "Holds between two entities where the first develops, by one or more developmental processes, from the second; for example a cell type developing from a precursor cell type or a tissue developing from an embryonic primordium. Corresponds to RO:0002202." ;
    skos:exactMatch <http://purl.obolibrary.org/obo/BTO_develops_from>,
        <http://purl.obolibrary.org/obo/DDANAT_develops_from>,
        FMA:develops_from,
        RO:0002202 ;
    skos:inScheme biolink: ;
    skos:narrowMatch RO:0002207,
        RO:0002225,
        RO:0002226 ;
    biolink:canonical_predicate true .

biolink:diagnoses a owl:ObjectProperty ;
    rdfs:label "diagnoses" ;
    rdfs:domain biolink:DiagnosticAid ;
    rdfs:range biolink:DiseaseOrPhenotypicFeature ;
    rdfs:subPropertyOf biolink:related_to_at_instance_level ;
    skos:closeMatch <http://purl.obolibrary.org/obo/NCIT_C15220>,
        SIO:001331 ;
    skos:definition "a relationship that identifies the nature of (an illness or other problem) by examination of the symptoms." ;
    skos:exactMatch DrugCentral:5271,
        SEMMEDDB:DIAGNOSES ;
    skos:inScheme biolink: ;
    biolink:canonical_predicate true .

biolink:directly_physically_interacts_with a owl:DatatypeProperty,
        owl:SymmetricProperty ;
    rdfs:label "directly physically interacts with" ;
    rdfs:subPropertyOf biolink:physically_interacts_with ;
    skos:broadMatch RO:0002578,
        SIO:000203 ;
    skos:definition "A causal mechanism mediated by a direct contact between the effector and target entities (this contact may be weak or strong, transient or stable)." ;
    skos:exactMatch RO:0002436 ;
    skos:inScheme biolink: ;
    skos:narrowMatch CTD:affects_binding,
        <http://identifiers.org/drugbank/chelator>,
        PHAROS:drug_targets,
        DGIdb:cofactor ;
    biolink:canonical_predicate true .

biolink:disease_has_basis_in a owl:DatatypeProperty ;
    rdfs:label "disease has basis in" ;
    rdfs:subPropertyOf biolink:related_to_at_instance_level ;
    skos:definition "A relation that holds between a disease and an entity where the state of the entity has contribution to the disease." ;
    skos:inScheme biolink: ;
    skos:narrowMatch <http://purl.obolibrary.org/obo/MONDO_disease_has_basis_in_accumulation_of>,
        <http://purl.obolibrary.org/obo/MONDO_disease_has_basis_in_development_of> ;
    biolink:canonical_predicate true .

biolink:disease_has_location a owl:DatatypeProperty ;
    rdfs:label "disease has location" ;
    rdfs:subPropertyOf biolink:related_to ;
    skos:definition "A relationship between a disease and an anatomical entity where the disease has one or more features that are located in that entity." ;
    skos:exactMatch <http://purl.obolibrary.org/obo/MONDO_disease_has_location>,
        RO:0004026 ;
    skos:inScheme biolink: .

biolink:disrupts a owl:DatatypeProperty ;
    rdfs:label "disrupts" ;
    rdfs:subPropertyOf biolink:affects ;
    skos:altLabel "disease causes disruption of" ;
    skos:definition "describes a relationship where one entity degrades or interferes with the structure, function, or occurrence of another." ;
    skos:exactMatch SEMMEDDB:DISRUPTS,
        CHEMBL.MECHANISM:disrupting_agent ;
    skos:inScheme biolink: ;
    skos:narrowMatch RO:0004024,
        RO:0004025 ;
    biolink:canonical_predicate true ;
    biolink:opposite_of "enables" .

biolink:editor a owl:ObjectProperty ;
    rdfs:label "editor" ;
    rdfs:domain biolink:Agent ;
    rdfs:range biolink:Publication ;
    rdfs:subPropertyOf biolink:contributor ;
    skos:definition "editor of a compiled work such as a book or a periodical (newspaper or an academic journal). Note that in the case of publications which have a containing \"published in\" node property, the editor association may not be attached directly to the embedded child publication, but only made in between the parent's publication node and the editorial agent of the encompassing publication (e.g. only from the Book referenced by the 'published_in' property of a book chapter Publication node)." ;
    skos:exactMatch WIKIDATA_PROPERTY:P98 ;
    skos:inScheme biolink: .

biolink:enables a owl:ObjectProperty ;
    rdfs:label "enables" ;
    rdfs:domain biolink:PhysicalEntity ;
    rdfs:range biolink:BiologicalProcessOrActivity ;
    rdfs:subPropertyOf biolink:participates_in ;
    skos:definition "holds between a physical entity and a process, where the physical entity executes the process" ;
    skos:exactMatch RO:0002327 ;
    skos:inScheme biolink: ;
    biolink:canonical_predicate true .

biolink:exacerbates_condition a owl:ObjectProperty ;
    rdfs:label "exacerbates condition" ;
    rdfs:domain biolink:ChemicalOrDrugOrTreatment ;
    rdfs:range biolink:DiseaseOrPhenotypicFeature ;
    rdfs:subPropertyOf biolink:affects,
        biolink:promotes_condition ;
    skos:altLabel "detrimental for condition",
        "exacerbates" ;
    skos:broadMatch SEMMEDDB:COMPLICATES ;
    skos:definition """Holds between a substance, procedure, or activity and an existing medical condition (disease or phenotypic
 feature) where the substance, procedure, or activity worsens some or all aspects of the condition.""" ;
    skos:exactMatch RO:0003309 ;
    skos:inScheme biolink: ;
    biolink:canonical_predicate true ;
    biolink:opposite_of "ameliorates condition" .

biolink:expressed_in a owl:ObjectProperty ;
    rdfs:label "expressed in" ;
    rdfs:domain biolink:GeneOrGeneProduct ;
    rdfs:range biolink:AnatomicalEntity ;
    rdfs:subPropertyOf biolink:located_in ;
    skos:definition "holds between a gene or gene product and an anatomical entity in which it is expressed" ;
    skos:exactMatch RO:0002206 ;
    skos:inScheme biolink: ;
    skos:narrowMatch <http://purl.obolibrary.org/obo/NCIT_R46>,
        <http://purl.obolibrary.org/obo/NCIT_R49> ;
    biolink:canonical_predicate true .

biolink:food_component_of a owl:ObjectProperty ;
    rdfs:label "food component of" ;
    rdfs:domain biolink:ChemicalEntity ;
    rdfs:range biolink:ChemicalEntity ;
    rdfs:subPropertyOf biolink:part_of ;
    owl:inverseOf biolink:has_food_component ;
    skos:definition "holds between a one or more chemical entities present in food, irrespective of nutritional value (i.e. could also be a contaminant or additive)" ;
    skos:inScheme biolink: .

biolink:gene_associated_with_condition a owl:ObjectProperty ;
    rdfs:label "gene associated with condition" ;
    rdfs:domain biolink:Gene ;
    rdfs:range biolink:DiseaseOrPhenotypicFeature ;
    rdfs:subPropertyOf biolink:genetically_associated_with ;
    skos:broadMatch <http://purl.obolibrary.org/obo/GENO_0000840>,
        <http://purl.obolibrary.org/obo/GENO_0000841> ;
    skos:definition "holds between a gene and a disease or phenotypic feature that the gene or its alleles/products may influence, contribute to, or correlate with" ;
    skos:inScheme biolink: ;
    skos:narrowMatch <http://purl.obolibrary.org/obo/NCIT_R175>,
        <http://purl.obolibrary.org/obo/NCIT_R38>,
        <http://purl.obolibrary.org/obo/NCIT_R48> ;
    biolink:canonical_predicate true .

biolink:gene_product_of a owl:ObjectProperty ;
    rdfs:label "gene product of" ;
    rdfs:domain biolink:GeneProductMixin ;
    rdfs:range biolink:Gene ;
    rdfs:subPropertyOf biolink:related_to_at_instance_level ;
    skos:definition "definition x has gene product of y if and only if y is a gene (SO:0000704) that participates in some gene expression process (GO:0010467) where the output of thatf process is either y or something that is ribosomally translated from x" ;
    skos:exactMatch RO:0002204 ;
    skos:inScheme biolink: ;
    biolink:canonical_predicate true .

biolink:has_active_ingredient a owl:ObjectProperty ;
    rdfs:label "has active ingredient" ;
    rdfs:domain biolink:Drug ;
    rdfs:range biolink:MolecularEntity ;
    rdfs:subPropertyOf biolink:has_part ;
    skos:definition "holds between a drug and a molecular entity in which the latter is a part of the former, and is a biologically active component" ;
    skos:inScheme biolink: ;
    skos:mappingRelation RO:0002248 ;
    biolink:canonical_predicate true ;
    biolink:opposite_of "is excipient of" .

biolink:has_adverse_event a owl:ObjectProperty ;
    rdfs:label "has adverse event" ;
    rdfs:domain biolink:ChemicalOrDrugOrTreatment ;
    rdfs:range biolink:DiseaseOrPhenotypicFeature ;
    rdfs:subPropertyOf biolink:affects ;
    skos:altLabel "adverse effect" ;
    skos:definition "An untoward medical occurrence in a patient or clinical investigation subject that happens during treatment with a therapeutic agent. Adverse events may be caused by something other than the drug or therapy being given and may include abnormal laboratory finding, symptoms, or diseases temporally associated with the treatment, whether or not considered related to the treatment. Adverse events are unintended effects that occur when a medication is administered correctly." ;
    skos:inScheme biolink: ;
    biolink:canonical_predicate true .

biolink:has_completed a owl:DatatypeProperty ;
    rdfs:label "has completed" ;
    rdfs:subPropertyOf biolink:related_to_at_instance_level ;
    skos:definition "holds between an entity and a process that the entity is capable of and has completed" ;
    skos:exactMatch <http://purl.obolibrary.org/obo/CL_has_completed> ;
    skos:inScheme biolink: ;
    biolink:canonical_predicate true ;
    biolink:opposite_of "has not completed" .

biolink:has_decreased_amount a owl:DatatypeProperty ;
    rdfs:label "has decreased amount" ;
    rdfs:subPropertyOf biolink:related_to_at_instance_level ;
    skos:definition "Holds between an entity and a component that is present at lower amount than in a reference state or sibling entity; used for comparative compositional statements." ;
    skos:inScheme biolink: ;
    skos:narrowMatch <http://purl.obolibrary.org/obo/CL_has_low_plasma_membrane_amount> ;
    biolink:canonical_predicate true ;
    biolink:opposite_of "has increased amount" .

biolink:has_excipient a owl:ObjectProperty ;
    rdfs:label "has excipient" ;
    rdfs:domain biolink:Drug ;
    rdfs:range biolink:MolecularEntity ;
    rdfs:subPropertyOf biolink:has_part ;
    skos:definition "holds between a drug and a molecular entities in which the latter is a part of the former, and is a biologically inactive component" ;
    skos:inScheme biolink: ;
    skos:mappingRelation WIKIDATA:Q902638 ;
    biolink:canonical_predicate true .

biolink:has_increased_amount a owl:DatatypeProperty ;
    rdfs:label "has increased amount" ;
    rdfs:subPropertyOf biolink:related_to_at_instance_level ;
    skos:definition "Holds between an entity and a component that is present at higher amount than in a reference state or sibling entity; used for comparative compositional statements." ;
    skos:inScheme biolink: ;
    skos:narrowMatch <http://purl.obolibrary.org/obo/CL_has_high_plasma_membrane_amount> ;
    biolink:canonical_predicate true ;
    biolink:opposite_of "has decreased amount" .

biolink:has_manifestation a owl:DatatypeProperty ;
    rdfs:label "has manifestation" ;
    rdfs:domain biolink:Disease ;
    rdfs:subPropertyOf biolink:related_to_at_instance_level ;
    owl:inverseOf biolink:manifestation_of ;
    skos:inScheme biolink: .

biolink:has_member a owl:DatatypeProperty ;
    rdfs:label "has member" ;
    rdfs:subPropertyOf biolink:related_to_at_concept_level ;
    skos:definition "Defines a mereological relation between a collection and an item." ;
    skos:exactMatch RO:0002351,
        skos:member ;
    skos:inScheme biolink: .

biolink:has_metabolite a owl:ObjectProperty ;
    rdfs:label "has metabolite" ;
    rdfs:domain biolink:MolecularEntity ;
    rdfs:range biolink:MolecularEntity ;
    rdfs:subPropertyOf biolink:derives_into ;
    skos:definition "holds between two molecular entities in which the second one is derived from the first one as a product of metabolism" ;
    skos:exactMatch <http://purl.obolibrary.org/obo/CHEBI_25212> ;
    skos:inScheme biolink: ;
    skos:note "The CHEBI ID represents a role rather than a predicate" ;
    biolink:canonical_predicate true .

biolink:has_mode_of_inheritance a owl:ObjectProperty ;
    rdfs:label "has mode of inheritance" ;
    rdfs:domain biolink:DiseaseOrPhenotypicFeature ;
    rdfs:range biolink:GeneticInheritance ;
    rdfs:subPropertyOf biolink:has_manifestation ;
    skos:definition "Relates a disease or phenotypic feature to its observed genetic segregation and assumed associated underlying DNA manifestation (i.e. autosomal, sex or mitochondrial chromosome)." ;
    skos:inScheme biolink: ;
    biolink:canonical_predicate true .

biolink:has_molecular_consequence a owl:ObjectProperty ;
    rdfs:label "has molecular consequence" ;
    rdfs:range biolink:OntologyClass ;
    rdfs:subPropertyOf biolink:related_to_at_instance_level ;
    skos:altLabel "allele has activity" ;
    skos:definition "connects a sequence variant to a class describing the molecular consequence. E.g.  SO:0001583" ;
    skos:inScheme biolink: ;
    skos:narrowMatch <http://purl.obolibrary.org/obo/NCIT_allele_has_activity> ;
    biolink:canonical_predicate true .

biolink:has_not_completed a owl:DatatypeProperty ;
    rdfs:label "has not completed" ;
    rdfs:subPropertyOf biolink:related_to_at_instance_level ;
    skos:definition "holds between an entity and a process that the entity is capable of, but has not completed" ;
    skos:exactMatch <http://purl.obolibrary.org/obo/CL_has_not_completed> ;
    skos:inScheme biolink: ;
    biolink:canonical_predicate true ;
    biolink:opposite_of "has completed" .

biolink:has_nutrient a owl:ObjectProperty ;
    rdfs:label "has nutrient" ;
    rdfs:domain biolink:ChemicalEntity ;
    rdfs:range biolink:ChemicalEntity ;
    rdfs:subPropertyOf biolink:has_food_component ;
    skos:definition "one or more nutrients which are growth factors for a living organism" ;
    skos:exactMatch WIKIDATA:Q181394 ;
    skos:inScheme biolink: ;
    biolink:canonical_predicate true .

biolink:has_phenotype a owl:ObjectProperty ;
    rdfs:label "has phenotype" ;
    rdfs:domain biolink:BiologicalEntity ;
    rdfs:range biolink:PhenotypicFeature ;
    rdfs:subPropertyOf biolink:related_to_at_instance_level ;
    skos:altLabel "disease presents symptom" ;
    skos:broadMatch <http://purl.obolibrary.org/obo/NCIT_R108>,
        <http://purl.obolibrary.org/obo/NCIT_R115> ;
    skos:definition "holds between a biological entity and a phenotype, where a phenotype is construed broadly as any kind of quality of an organism part, a collection of these qualities, or a change in quality or qualities (e.g. abnormally increased temperature). In SNOMEDCT, disorders with keyword 'characterized by' should translate into this predicate." ;
    skos:editorialNote "check the range" ;
    skos:exactMatch RO:0002200 ;
    skos:inScheme biolink: ;
    skos:narrowMatch <http://purl.obolibrary.org/obo/NCIT_R89>,
        RO:0004022,
        RO:0004029,
        DOID-PROPERTY:has_symptom ;
    biolink:canonical_predicate true .

biolink:has_plasma_membrane_part a owl:DatatypeProperty ;
    rdfs:label "has plasma membrane part" ;
    rdfs:subPropertyOf biolink:has_part ;
    skos:definition "Holds between a cell c and a protein complex or protein p if and only if that cell has as part a plasma_membrane[GO:0005886], and that plasma membrane has p as part." ;
    skos:exactMatch RO:0002104 ;
    skos:inScheme biolink: ;
    biolink:canonical_predicate true .

biolink:has_sequence_location a owl:ObjectProperty ;
    rdfs:label "has sequence location" ;
    rdfs:domain biolink:NucleicAcidEntity ;
    rdfs:range biolink:NucleicAcidEntity ;
    rdfs:subPropertyOf biolink:related_to_at_instance_level ;
    skos:definition "holds between two nucleic acid entities when the subject can be localized in sequence coordinates on the object. For example, between an exon and a chromosome/contig." ;
    skos:exactMatch <http://biohackathon.org/resource/faldo#location> ;
    skos:inScheme biolink: ;
    biolink:canonical_predicate true .

biolink:has_side_effect a owl:ObjectProperty ;
    rdfs:label "has side effect" ;
    rdfs:domain biolink:ChemicalOrDrugOrTreatment ;
    rdfs:range biolink:DiseaseOrPhenotypicFeature ;
    rdfs:subPropertyOf biolink:affects ;
    skos:altLabel "adverse drug reaction" ;
    skos:definition "An unintended, but predictable, secondary effect shown to be correlated with a therapeutic agent, drug or treatment. Side effects happen at normal, recommended doses or treatments, and are unrelated to the intended purpose of the medication." ;
    skos:editorialNote "Side effects are listed on drug labels. There can be positive side effects, while adverse events are always negative. Aeolus, Sider are both resources that provide side effects." ;
    skos:exactMatch <http://purl.obolibrary.org/obo/NCIT_C2861> ;
    skos:inScheme biolink: ;
    biolink:canonical_predicate true .

biolink:has_substrate a owl:ObjectProperty ;
    rdfs:label "has substrate" ;
    rdfs:domain biolink:ChemicalEntityOrGeneOrGeneProduct ;
    rdfs:range biolink:ChemicalEntityOrGeneOrGeneProduct ;
    rdfs:subPropertyOf biolink:has_participant ;
    skos:definition "Holds between a biochemical reaction or catalytic process and a chemical entity that is acted upon (consumed or transformed) by that reaction." ;
    skos:inScheme biolink: ;
    biolink:canonical_predicate true .

biolink:has_variant_part a owl:DatatypeProperty ;
    rdfs:label "has variant part" ;
    rdfs:subPropertyOf biolink:has_part ;
    skos:definition "holds between a nucleic acid entity and a nucleic acid entity that is a sub-component of it" ;
    skos:exactMatch <http://purl.obolibrary.org/obo/GENO_0000382> ;
    skos:inScheme biolink: ;
    biolink:canonical_predicate true .

biolink:in_clinical_trials_for a owl:ObjectProperty ;
    rdfs:label "in clinical trials for" ;
    rdfs:domain biolink:ChemicalOrDrugOrTreatment ;
    rdfs:range biolink:DiseaseOrPhenotypicFeature ;
    rdfs:subPropertyOf biolink:studied_to_treat,
        biolink:treats_or_applied_or_studied_to_treat ;
    skos:definition "Holds between an intervention and a medical condition, and reports that a clinical trial  is being or has been performed in human patients to test the potential of the intervention to treat the medical condition (e.g. to ameliorate, stabilize, or cure the condition, or to delay, prevent, or reduce the risk of it manifesting in the first place)." ;
    skos:editorialNote "This predicate should be used when a source reports a clinical trial where the intervention is being or was interrogated, regardless of the phase of the trial, or its ultimate outcome.  Information about phase and outcome can be capture using other modeling elements." ;
    skos:inScheme biolink: ;
    biolink:canonical_predicate true .

biolink:increases_amount_or_activity_of a owl:DatatypeProperty ;
    rdfs:label "increases amount or activity of" ;
    rdfs:subPropertyOf biolink:related_to_at_instance_level ;
    skos:definition "A grouping mixin to help with searching for all the predicates that increase the amount or activity of the object." ;
    skos:inScheme biolink: .

biolink:increases_sensitivity_to a owl:ObjectProperty ;
    rdfs:label "increases sensitivity to" ;
    rdfs:domain biolink:ChemicalEntityOrGeneOrGeneProduct ;
    rdfs:range biolink:ChemicalEntityOrGeneOrGeneProduct ;
    rdfs:subPropertyOf biolink:affects_sensitivity_to ;
    skos:definition "holds between two chemical entities or genes or gene products where the action or effect of one increases the susceptibility/sensitivity of a biological entity or system to the other" ;
    skos:exactMatch CTD:increases_response_to ;
    skos:inScheme biolink: ;
    biolink:canonical_predicate true ;
    biolink:opposite_of "decreases sensitivity to" .

biolink:is_chemical_role_of a owl:ObjectProperty ;
    rdfs:label "is chemical role of" ;
    rdfs:domain biolink:ChemicalRole ;
    rdfs:range biolink:ChemicalEntity ;
    rdfs:subPropertyOf biolink:related_to_at_concept_level ;
    owl:inverseOf biolink:has_chemical_role ;
    skos:definition "Holds between a chemical role and a chemical entity that exhibits that role." ;
    skos:inScheme biolink: .

biolink:is_frameshift_variant_of a owl:ObjectProperty ;
    rdfs:label "is frameshift variant of" ;
    rdfs:domain biolink:SequenceVariant ;
    rdfs:range biolink:GenomicEntity ;
    rdfs:subPropertyOf biolink:is_sequence_variant_of ;
    skos:altLabel "frameshift variant",
        "start lost",
        "stop lost" ;
    skos:definition "holds between a sequence variant and a gene, such the sequence variant causes a disruption of the translational reading frame, because the number of nucleotides inserted or deleted is not a multiple of three." ;
    skos:exactMatch <http://purl.obolibrary.org/obo/SO_0001589> ;
    skos:inScheme biolink: ;
    biolink:canonical_predicate true .

biolink:is_input_of a owl:ObjectProperty ;
    rdfs:label "is input of" ;
    rdfs:domain biolink:NamedThing ;
    rdfs:range biolink:BiologicalProcessOrActivity ;
    rdfs:subPropertyOf biolink:participates_in ;
    owl:inverseOf biolink:has_input ;
    skos:exactMatch RO:0002352 ;
    skos:inScheme biolink: .

biolink:is_missense_variant_of a owl:ObjectProperty ;
    rdfs:label "is missense variant of" ;
    rdfs:domain biolink:SequenceVariant ;
    rdfs:range biolink:GenomicEntity ;
    rdfs:subPropertyOf biolink:is_sequence_variant_of ;
    skos:definition "holds between a gene  and a sequence variant, such the sequence variant results in a different amino acid sequence but where the length is preserved." ;
    skos:exactMatch <http://purl.obolibrary.org/obo/SO_0001583> ;
    skos:inScheme biolink: ;
    biolink:canonical_predicate true .

biolink:is_nearby_variant_of a owl:ObjectProperty ;
    rdfs:label "is nearby variant of" ;
    rdfs:domain biolink:SequenceVariant ;
    rdfs:range biolink:GenomicEntity ;
    rdfs:subPropertyOf biolink:is_sequence_variant_of ;
    skos:definition "holds between a sequence variant and a gene sequence that the variant is genomically close to." ;
    skos:inScheme biolink: ;
    biolink:canonical_predicate true .

biolink:is_non_coding_variant_of a owl:ObjectProperty ;
    rdfs:label "is non coding variant of" ;
    rdfs:domain biolink:SequenceVariant ;
    rdfs:range biolink:GenomicEntity ;
    rdfs:subPropertyOf biolink:is_sequence_variant_of ;
    skos:definition "holds between a sequence variant and a gene, where the variant does not affect the coding sequence" ;
    skos:inScheme biolink: ;
    biolink:canonical_predicate true .

biolink:is_nonsense_variant_of a owl:ObjectProperty ;
    rdfs:label "is nonsense variant of" ;
    rdfs:domain biolink:SequenceVariant ;
    rdfs:range biolink:GenomicEntity ;
    rdfs:subPropertyOf biolink:is_sequence_variant_of ;
    skos:broadMatch <http://purl.obolibrary.org/obo/SO_0002054> ;
    skos:definition "holds between a sequence variant and a gene, such the sequence variant results in a premature stop codon" ;
    skos:inScheme biolink: ;
    biolink:canonical_predicate true .

biolink:is_splice_site_variant_of a owl:ObjectProperty ;
    rdfs:label "is splice site variant of" ;
    rdfs:domain biolink:SequenceVariant ;
    rdfs:range biolink:GenomicEntity ;
    rdfs:subPropertyOf biolink:is_sequence_variant_of ;
    skos:definition "holds between a sequence variant and a gene, such the sequence variant is in the canonical splice site of one of the gene's exons." ;
    skos:exactMatch <http://purl.obolibrary.org/obo/SO_0001629> ;
    skos:inScheme biolink: ;
    biolink:canonical_predicate true .

biolink:is_synonymous_variant_of a owl:ObjectProperty ;
    rdfs:label "is synonymous variant of" ;
    rdfs:domain biolink:SequenceVariant ;
    rdfs:range biolink:GenomicEntity ;
    rdfs:subPropertyOf biolink:is_sequence_variant_of ;
    skos:definition "holds between a sequence variant and a gene, such the sequence variant is in the coding sequence of the gene, but results in the same amino acid sequence" ;
    skos:exactMatch <http://purl.obolibrary.org/obo/SO_0001819> ;
    skos:inScheme biolink: ;
    biolink:canonical_predicate true .

biolink:lacks_part a owl:DatatypeProperty ;
    rdfs:label "lacks part" ;
    rdfs:subPropertyOf biolink:related_to_at_instance_level ;
    skos:definition "Holds between an entity and a component that is absent from it relative to a reference type; for example a cell type lacking a particular organelle or a protein lacking a particular domain. Corresponds to CL:lacks_part / PR:lacks_part." ;
    skos:exactMatch <http://purl.obolibrary.org/obo/CL_lacks_part>,
        <http://purl.obolibrary.org/obo/PR_lacks_part> ;
    skos:inScheme biolink: ;
    skos:narrowMatch <http://purl.obolibrary.org/obo/CL_lacks_plasma_membrane_part> ;
    biolink:canonical_predicate true ;
    biolink:opposite_of "has part" .

biolink:mentions a owl:DatatypeProperty ;
    rdfs:label "mentions" ;
    rdfs:subPropertyOf biolink:related_to_at_instance_level ;
    skos:definition "refers to is a relation between one information content entity and the named thing that it makes reference to." ;
    skos:exactMatch IAO:0000142 ;
    skos:inScheme biolink: ;
    skos:narrowMatch SIO:000628 .

biolink:model_of a owl:DatatypeProperty ;
    rdfs:label "model of" ;
    rdfs:subPropertyOf biolink:related_to_at_instance_level ;
    skos:definition "holds between a thing and some other thing it approximates for purposes of scientific study, in virtue of its exhibiting similar features of the studied entity." ;
    skos:exactMatch RO:0003301 ;
    skos:inScheme biolink: ;
    skos:narrowMatch <http://purl.obolibrary.org/obo/FOODON_00001301> ;
    biolink:canonical_predicate true .

biolink:occurs_in a owl:DatatypeProperty ;
    rdfs:label "occurs in" ;
    rdfs:subPropertyOf biolink:related_to_at_instance_level ;
    skos:closeMatch <http://purl.obolibrary.org/obo/BFO_0000067>,
        <http://purl.obolibrary.org/obo/SNOMED_has_occurrence>,
        <http://purl.obolibrary.org/obo/UBERON_site_of> ;
    skos:definition "holds between a process and a material entity or site within which the process occurs" ;
    skos:exactMatch <http://purl.obolibrary.org/obo/BFO_0000066>,
        <http://purl.obolibrary.org/obo/SNOMED_occurs_in>,
        PathWhiz:has_location ;
    skos:inScheme biolink: ;
    skos:narrowMatch LOINC:has_imaged_location,
        RO:0002231,
        RO:0002232,
        <http://purl.obolibrary.org/obo/SNOMED_has_direct_procedure_site>,
        <http://purl.obolibrary.org/obo/SNOMED_has_direct_site>,
        <http://purl.obolibrary.org/obo/SNOMED_has_procedure_site>,
        UBERON_CORE:site_of,
        PathWhiz:in_species,
        SEMMEDDB:OCCURS_IN,
        SEMMEDDB:PROCESS_OF ;
    biolink:canonical_predicate true .

biolink:precedes a owl:ObjectProperty ;
    rdfs:label "precedes" ;
    rdfs:domain biolink:Occurrent ;
    rdfs:range biolink:Occurrent ;
    rdfs:subPropertyOf biolink:temporally_related_to ;
    skos:broadMatch WIKIDATA_PROPERTY:P156 ;
    skos:closeMatch RO:0002263,
        RO:0002264 ;
    skos:definition "holds between two processes, where one completes before the other begins" ;
    skos:exactMatch <http://purl.obolibrary.org/obo/BFO_0000063>,
        <http://purl.obolibrary.org/obo/SNOMED_occurs_before>,
        SEMMEDDB:PRECEDES ;
    skos:inScheme biolink: ;
    skos:narrowMatch FMA:transforms_into,
        RO:0002090,
        RO:0002411,
        RO:0002412 ;
    biolink:canonical_predicate true .

biolink:predisposes_to_condition a owl:ObjectProperty ;
    rdfs:label "predisposes to condition" ;
    rdfs:domain biolink:ChemicalOrDrugOrTreatment ;
    rdfs:range biolink:DiseaseOrPhenotypicFeature ;
    rdfs:subPropertyOf biolink:affects_likelihood_of,
        biolink:promotes_condition ;
    skos:altLabel "risk factor for" ;
    skos:broadMatch SEMMEDDB:PREDISPOSES ;
    skos:definition "Holds between two entities where the presence or application of one increases the chance that the other will come to be." ;
    skos:inScheme biolink: ;
    biolink:canonical_predicate true .

biolink:preventative_for_condition a owl:ObjectProperty ;
    rdfs:label "preventative for condition" ;
    rdfs:domain biolink:ChemicalOrDrugOrTreatment ;
    rdfs:range biolink:DiseaseOrPhenotypicFeature ;
    rdfs:subPropertyOf biolink:affects_likelihood_of,
        biolink:treats ;
    skos:altLabel "prevents",
        "prophylactic for" ;
    skos:broadMatch SEMMEDDB:PREVENTS ;
    skos:definition "Holds between a substance, procedure, or activity and a medical condition (disease or phenotypic feature), and states that the  substance, procedure, or activity is able to prevent it manifesting in the first place." ;
    skos:inScheme biolink: ;
    biolink:canonical_predicate true ;
    biolink:opposite_of "promotes condition" .

biolink:produces a owl:DatatypeProperty ;
    rdfs:label "produces" ;
    rdfs:subPropertyOf biolink:related_to_at_instance_level ;
    skos:definition "holds between a material entity and a product that is generated through the intentional actions or functioning of the material entity" ;
    skos:exactMatch RO:0003000,
        SEMMEDDB:PRODUCES,
        WIKIDATA_PROPERTY:P1056 ;
    skos:inScheme biolink: ;
    skos:narrowMatch <http://purl.obolibrary.org/obo/NCIT_R29>,
        <http://purl.obolibrary.org/obo/SNOMED_has_process_output>,
        <http://purl.obolibrary.org/obo/SNOMED_specimen_procedure_of> ;
    skos:relatedMatch GOREL:0001010 ;
    biolink:canonical_predicate true .

biolink:provider a owl:DatatypeProperty ;
    rdfs:label "provider" ;
    rdfs:subPropertyOf biolink:contributor ;
    skos:definition "person, group, organization or project that provides a piece of information." ;
    skos:inScheme biolink: .

biolink:publisher a owl:ObjectProperty ;
    rdfs:label "publisher" ;
    rdfs:domain biolink:Agent ;
    rdfs:range biolink:Publication ;
    rdfs:subPropertyOf biolink:contributor ;
    skos:definition "organization or person responsible for publishing books, periodicals, podcasts, games or software. Note that in the case of publications which have a containing \"published in\" node property, the publisher association may not be attached directly to the embedded child publication, but only made in between the parent's publication node and the publisher agent of the encompassing publication (e.g. only from the Journal referenced by the 'published_in' property of an journal article Publication node)." ;
    skos:exactMatch dct:publisher,
        WIKIDATA_PROPERTY:P123 ;
    skos:inScheme biolink: .

biolink:regulates a owl:ObjectProperty ;
    rdfs:label "regulates" ;
    rdfs:domain biolink:PhysicalEssenceOrOccurrent ;
    rdfs:range biolink:PhysicalEssenceOrOccurrent ;
    rdfs:subPropertyOf biolink:affects,
        biolink:interacts_with ;
    skos:broadMatch RO:0002295,
        RO:0002332,
        RO:0002448,
        CHEMBL.MECHANISM:modulator,
        WIKIDATA_PROPERTY:P128 ;
    skos:definition "A more specific form of affects, that implies the effect results from a biologically evolved control mechanism. Gene-affects-gene relationships will (almost) always involve regulation.  Exogenous/environmental chemical-affects-gene relationships are not cases of regulation in this definition. Instead these would be captured using the 'affects' predicate, or possibly one of the 'interacts with' predicates depending on the nature of the interaction." ;
    skos:editorialNote "The RO definition of 'directly regulates the activity of' is an exact_mapping here because it describes genetic regulation from the point of view of one genetic entity regulating another, as opposed to \"RO:0002211\" which describes process to process regulation." ;
    skos:exactMatch RO:0002448 ;
    skos:inScheme biolink: ;
    biolink:canonical_predicate true .

biolink:subclass_of a owl:ObjectProperty ;
    rdfs:label "subclass of" ;
    rdfs:domain biolink:OntologyClass ;
    rdfs:range biolink:OntologyClass ;
    rdfs:subPropertyOf biolink:related_to_at_concept_level ;
    skos:closeMatch LOINC:class_of,
        LOINC:has_class ;
    skos:definition "holds between two classes where the domain class is a specialization of the range class" ;
    skos:exactMatch MESH:isa,
        RXNORM:isa,
        <http://purl.obolibrary.org/obo/GO_isa>,
        rdfs:subClassOf,
        SEMMEDDB:ISA,
        CHEMBL.MECHANISM:subset_of,
        VANDF:isa,
        WIKIDATA_PROPERTY:P279 ;
    skos:inScheme biolink: ;
    skos:narrowMatch LOINC:has_archetype,
        LOINC:has_parent_group,
        LOINC:is_presence_guidance_for,
        NDDF:has_dose_form,
        RXNORM:has_dose_form,
        RXNORM:has_doseformgroup,
        <http://purl.obolibrary.org/obo/CHEBI_has_parent_hydride>,
        <http://purl.obolibrary.org/obo/NCIT_A11>,
        <http://purl.obolibrary.org/obo/NCIT_A14>,
        <http://purl.obolibrary.org/obo/NCIT_A16>,
        <http://purl.obolibrary.org/obo/NCIT_A3>,
        <http://purl.obolibrary.org/obo/NCIT_R36>,
        <http://purl.obolibrary.org/obo/NCIT_R42>,
        <http://purl.obolibrary.org/obo/NCIT_gene_product_has_chemical_classification>,
        <http://purl.obolibrary.org/obo/SNOMED_entire_anatomy_structure_of>,
        <http://purl.obolibrary.org/obo/SNOMED_has_dose_form>,
        rdfs:subPropertyOf ;
    biolink:canonical_predicate true .

biolink:target_for a owl:ObjectProperty ;
    rdfs:label "target for" ;
    rdfs:domain biolink:Gene ;
    rdfs:range biolink:Disease ;
    rdfs:subPropertyOf biolink:related_to_at_instance_level ;
    skos:definition "A gene is a target of a disease when its products are druggable and when a drug interaction with the gene product could have a therapeutic effect" ;
    skos:inScheme biolink: ;
    biolink:canonical_predicate true .

biolink:tested_by_preclinical_trials_of a owl:ObjectProperty ;
    rdfs:label "tested by preclinical trials of" ;
    rdfs:domain biolink:DiseaseOrPhenotypicFeature ;
    rdfs:range biolink:ChemicalOrDrugOrTreatment ;
    rdfs:subPropertyOf biolink:subject_of_treatment_application_or_study_for_treatment_by,
        biolink:treated_in_studies_by ;
    owl:inverseOf biolink:in_preclinical_trials_for ;
    skos:inScheme biolink: .

biolink:transcribed_from a owl:ObjectProperty ;
    rdfs:label "transcribed from" ;
    rdfs:domain biolink:Transcript ;
    rdfs:range biolink:Gene ;
    rdfs:subPropertyOf biolink:related_to_at_instance_level ;
    skos:definition "x is transcribed from y if and only if x is synthesized from template y" ;
    skos:exactMatch RO:0002510,
        SIO:010081 ;
    skos:inScheme biolink: ;
    biolink:canonical_predicate true .

biolink:translates_to a owl:ObjectProperty ;
    rdfs:label "translates to" ;
    rdfs:domain biolink:Transcript ;
    rdfs:range biolink:Protein ;
    rdfs:subPropertyOf biolink:related_to_at_instance_level ;
    skos:closeMatch RO:0002513,
        SIO:010082 ;
    skos:definition "x (amino acid chain/polypeptide) is the ribosomal translation of y (transcript) if and only if a ribosome reads y (transcript) through a series of triplet codon-amino acid adaptor activities (GO:0030533) and produces x (amino acid chain/polypeptide)" ;
    skos:inScheme biolink: ;
    biolink:canonical_predicate true .

biolink:treated_by a owl:ObjectProperty ;
    rdfs:label "treated by" ;
    rdfs:domain biolink:DiseaseOrPhenotypicFeature ;
    rdfs:range biolink:ChemicalOrDrugOrTreatment ;
    rdfs:subPropertyOf biolink:subject_of_treatment_application_or_study_for_treatment_by ;
    owl:inverseOf biolink:treats ;
    skos:exactMatch <http://purl.obolibrary.org/obo/MONDO_disease_responds_to>,
        WIKIDATA_PROPERTY:P2176 ;
    skos:inScheme biolink: ;
    skos:narrowMatch RO:0002302 .

biolink:was_tested_for_effect_on a owl:ObjectProperty ;
    rdfs:label "was tested for effect on" ;
    rdfs:domain biolink:NamedThing ;
    rdfs:range biolink:NamedThing ;
    rdfs:subPropertyOf biolink:related_to_at_instance_level ;
    skos:altLabel "was assayed against",
        "was experimentally tested against" ;
    skos:definition "Reports that the subject was interrogated in an experiment to determine how it may affect the object. A relationship between some perturbing agent (usually a chemical compound) and some target entity, where the affect of the perturbing agent on the target entity was interrogated in a particular assay. The target might be a particular protein, tissue, phenotype, whole organism, cell line, or other type of biological entity." ;
    skos:inScheme biolink: ;
    biolink:canonical_predicate true .

<http://purl.obolibrary.org/obo/UO_0000000> a rdfs:Datatype ;
    owl:equivalentClass xsd:string .

<http://purl.obolibrary.org/obo/UO_0000046> a rdfs:Datatype ;
    owl:equivalentClass xsd:string .

<http://purl.obolibrary.org/obo/UO_0000105> a rdfs:Datatype ;
    owl:equivalentClass xsd:string .

os:AllSomeInterpretation a owl:Class ;
    rdfs:label "all_some" ;
    rdfs:subClassOf biolink:LogicalInterpretationEnum,
        linkml:PermissibleValue ;
    skos:definition "A modifier on a triple that causes the triple to be interpreted as an all-some statement." .

os:SomeSomeInterpretation a owl:Class ;
    rdfs:label "some_some" ;
    rdfs:subClassOf biolink:LogicalInterpretationEnum,
        linkml:PermissibleValue ;
    skos:definition "A modifier on a triple that causes the triple to be interpreted as a some-some statement" .

biolink:AccessibleDnaRegion a owl:Class ;
    rdfs:label "accessible dna region" ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:onProperty linkml:mixins ;
            owl:someValuesFrom biolink:ChemicalEntityOrGeneOrGeneProduct ],
        [ a owl:Restriction ;
            owl:onProperty linkml:mixins ;
            owl:someValuesFrom biolink:PhysicalEssence ],
        [ a owl:Restriction ;
            owl:onProperty linkml:mixins ;
            owl:someValuesFrom biolink:OntologyClass ],
        [ a owl:Restriction ;
            owl:onProperty linkml:mixins ;
            owl:someValuesFrom biolink:GenomicEntity ],
        biolink:RegulatoryRegion ;
    skos:altLabel "atac-seq accessible region",
        "dnase-seq accessible region" ;
    skos:definition "A region (or regions) of a chromatinized genome that has been measured to be more accessible to an enzyme such as DNase-I or Tn5 Transpose" ;
    skos:exactMatch <http://purl.obolibrary.org/obo/SO_0002231> ;
    skos:inScheme biolink: .

<https://w3id.org/biolink/vocab/AgentTypeEnum#computational_model> a owl:Class ;
    rdfs:label "computational_model" ;
    rdfs:subClassOf biolink:AgentTypeEnum,
        <https://w3id.org/biolink/vocab/AgentTypeEnum#automated_agent> ;
    skos:definition "An automated agent that generates knowledge statements (typically predictions) based on rules/logic explicitly encoded in an algorithm (e.g. heuristic models, supervised classifiers), or learned from patterns observed in data (e.g. ML models, unsupervised classifiers)." ;
    skos:editorialNote "The bar is quite low relatively for what is considered to be a ‘computational model’ by our definition. Even agents/tools that apply simple rules or logic to the output of an ingest or analysis pipeline to allow for a stronger or more general conclusion to be stated can qualify an agent as a model. For example, an ingest pipeline that applies rules to its ingest of clinical trials data to create a 'treats' prediction edge when the source reports a drug to be in phase 2 or 3 trials represents a computational model because it is automatically drawing a stronger conclusion than the source reports, based on logic encoded in the ingest pipeline. Similarly, a data analysis pipeline that is extended with rules to automatically generate broader conclusions based on dataset-specific statistical correlations (e.g. create a 'treats' edge when the analysis reveals a drug-disease correlation in the data with statistical scores that meet a certain threshold), would also qualify as a computational model by our definition." .

<https://w3id.org/biolink/vocab/AgentTypeEnum#data_analysis_pipeline> a owl:Class ;
    rdfs:label "data_analysis_pipeline" ;
    rdfs:subClassOf biolink:AgentTypeEnum,
        <https://w3id.org/biolink/vocab/AgentTypeEnum#automated_agent> ;
    skos:definition "An automated agent that executes an analysis workflow over data and reports the direct results of the analysis. These typically report statistical associations/correlations between variables in the input dataset, and do not interpret/infer broader conclusions from associations the analysis reveals in the data." ;
    skos:editorialNote "If an analysis pipeline includes any rules for generating broader conclusions based on the dataset-specific statistical correlations it calculates (e.g. create a 'treats' edge when the analysis reveals a drug-disease correlation in the data with statistical scores that meet a certain threshold) - we would consider this agent to be a Computational Model rather than just a Data Analysis Pipeline." .

<https://w3id.org/biolink/vocab/AgentTypeEnum#image_processing_agent> a owl:Class ;
    rdfs:label "image_processing_agent" ;
    rdfs:subClassOf biolink:AgentTypeEnum,
        <https://w3id.org/biolink/vocab/AgentTypeEnum#automated_agent> ;
    skos:definition "An automated agent that processes images to generate textual statements of knowledge derived from the image and/or expressed in text the image depicts (e.g. via OCR)." .

<https://w3id.org/biolink/vocab/AgentTypeEnum#manual_agent> a owl:Class ;
    rdfs:label "manual_agent" ;
    rdfs:subClassOf biolink:AgentTypeEnum,
        linkml:PermissibleValue ;
    skos:definition "A human agent who is responsible for generating a statement of knowledge. The human may utilize computationally generated information as evidence for the resulting knowledge, but the human is the one who ultimately interprets/reasons with this evidence to produce a statement of knowledge." .

<https://w3id.org/biolink/vocab/AgentTypeEnum#manual_validation_of_automated_agent> a owl:Class ;
    rdfs:label "manual_validation_of_automated_agent" ;
    rdfs:subClassOf biolink:AgentTypeEnum,
        linkml:PermissibleValue ;
    skos:definition "A human agent reviews and validates/approves the veracity of knowledge that is initially generated by an automated agent." ;
    skos:editorialNote "This term applies when a human was only involved in evaluating the veracity of a knowledge statement that was generated by an automated agent. It is important to indicate when such manual review has occurred, because it can give a user more confidence in an automated statement." .

<https://w3id.org/biolink/vocab/AgentTypeEnum#not_provided> a owl:Class ;
    rdfs:label "not_provided" ;
    rdfs:subClassOf biolink:AgentTypeEnum,
        linkml:PermissibleValue ;
    skos:definition "The agent type is not provided, typically because it cannot be determined from available information if the agent that generated the knowledge is manual or automated." .

<https://w3id.org/biolink/vocab/AgentTypeEnum#text_mining_agent> a owl:Class ;
    rdfs:label "text_mining_agent" ;
    rdfs:subClassOf biolink:AgentTypeEnum,
        <https://w3id.org/biolink/vocab/AgentTypeEnum#automated_agent> ;
    skos:definition "An automated agent that uses Natural Language Processing to recognize concepts and/or relationships in text, and report them using formally encoded semantics (e.g. as an edge in a knowledge graph)." ;
    skos:editorialNote "The original statement in the source text is typically made by a human / manual agent, but if a specific encoding of this knowledge is produced by a text-mining tool, it has an agent_type of 'text_mining_agent'. Examples of text mining agents include SemmedDB, and the Translator Text-Mining Knowledge Provider. Note that text-mining tools are prone to erroneous interpretation of concepts and relationships, and can fail to provide important details about the context in which the original knowledge was reported - so users should always consult the source text for a text-mined statement to assess its veracity and relevance." .

<https://w3id.org/biolink/vocab/ApprovalStatusEnum#discovery_and_development_phase> a owl:Class ;
    rdfs:label "discovery_and_development_phase" ;
    rdfs:subClassOf biolink:ApprovalStatusEnum,
        linkml:PermissibleValue ;
    skos:definition "Discovery & Development Phase. Discovery involves researchers finding new possibilities for medication through testing molecular compounds, noting unexpected effects from existing treatments, or the creation of new technology that allows novel ways of targeting medical products to sites in the body. Drug development occurs after researchers identify potential compounds for experiments." .

<https://w3id.org/biolink/vocab/ApprovalStatusEnum#fda_accelerated_approval> a owl:Class ;
    rdfs:label "fda_accelerated_approval" ;
    rdfs:subClassOf biolink:ApprovalStatusEnum,
        linkml:PermissibleValue ;
    skos:definition "When studying a new drug, it can sometimes take many years to learn whether a drug actually provides a real effect on how a patient survives, feels, or functions. A positive therapeutic effect that is clinically meaningful in the context of a given disease is known as “clinical benefit”. Mindful of the fact that it may take an extended period of time to measure a drug’s intended clinical benefit, in 1992 FDA instituted the Accelerated Approval regulations. These regulations allowed drugs for serious conditions that filled an unmet medical need to be approved based on a surrogate endpoint. Using a surrogate endpoint enabled the FDA to approve these drugs faster. For more information https://www.fda.gov/patients/fast-track-breakthrough-therapy-accelerated-approval-priority-review/accelerated-approval" .

<https://w3id.org/biolink/vocab/ApprovalStatusEnum#fda_breakthrough_therapy> a owl:Class ;
    rdfs:label "fda_breakthrough_therapy" ;
    rdfs:subClassOf biolink:ApprovalStatusEnum,
        linkml:PermissibleValue ;
    skos:definition "Breakthrough Therapy designation is a process designed to expedite the development and review of drugs that are intended to treat a serious condition and preliminary clinical evidence indicates that the drug may demonstrate substantial improvement over available therapy on a clinically significant endpoint(s). For more information https://www.fda.gov/patients/fast-track-breakthrough-therapy-accelerated-approval-priority-review/breakthrough-therapy" .

<https://w3id.org/biolink/vocab/ApprovalStatusEnum#fda_clinical_research_phase> a owl:Class ;
    rdfs:label "fda_clinical_research_phase" ;
    rdfs:subClassOf biolink:ApprovalStatusEnum,
        linkml:PermissibleValue ;
    skos:definition "Clinical Research Phase. Clinical research involves trials of the drug on people, and it is one of the most involved stages in the drug development and approval process. Clinical trials must answer specific questions and follow a protocol determined by the drug researcher or manufacturer." .

<https://w3id.org/biolink/vocab/ApprovalStatusEnum#fda_clinical_research_phase_1> a owl:Class ;
    rdfs:label "fda_clinical_research_phase_1" ;
    rdfs:subClassOf biolink:ApprovalStatusEnum,
        linkml:PermissibleValue ;
    skos:definition "In the FDA Clinical Research Phase, the Clinical Research Phase 1 involves 20 – 100 study participants and lasts several months. This phase is used to determine the safety and dosage of the drug, and about 70% of these drugs move on to the next clinical research phase." .

<https://w3id.org/biolink/vocab/ApprovalStatusEnum#fda_clinical_research_phase_2> a owl:Class ;
    rdfs:label "fda_clinical_research_phase_2" ;
    rdfs:subClassOf biolink:ApprovalStatusEnum,
        linkml:PermissibleValue ;
    skos:definition "In the FDA Clinical Research Phase, the Clinical Research Phase 2 involves up to several hundred people, who must have the disease or condition the drug supposes to treat. This phase can last from a few months to two years, and its purpose is to monitor the efficacy of the drug, as well as note side effects that may occur." .

<https://w3id.org/biolink/vocab/ApprovalStatusEnum#fda_clinical_research_phase_3> a owl:Class ;
    rdfs:label "fda_clinical_research_phase_3" ;
    rdfs:subClassOf biolink:ApprovalStatusEnum,
        linkml:PermissibleValue ;
    skos:definition "In the FDA Clinical Research Phase, the Clinical Research Phase 3 involves 300 – 3000 volunteers and can last up to four years. It is used to continue monitoring the efficacy of the drug, as well as exploring any longer-term adverse reactions." .

<https://w3id.org/biolink/vocab/ApprovalStatusEnum#fda_clinical_research_phase_4> a owl:Class ;
    rdfs:label "fda_clinical_research_phase_4" ;
    rdfs:subClassOf biolink:ApprovalStatusEnum,
        linkml:PermissibleValue ;
    skos:definition "In the FDA Clinical Research Phase, the Clinical Research Phase 4 involves several thousands of volunteers who have the disease or condition and continues to monitor safety and efficacy. If a drug passes this phase, it goes on to FDA review." .

<https://w3id.org/biolink/vocab/ApprovalStatusEnum#fda_fast_track> a owl:Class ;
    rdfs:label "fda_fast_track" ;
    rdfs:subClassOf biolink:ApprovalStatusEnum,
        linkml:PermissibleValue ;
    skos:definition "Fast track is a process designed to facilitate the development, and expedite the review of drugs to treat serious conditions and fill an unmet medical need. The purpose is to get important new drugs to the patient earlier. Fast Track addresses a broad range of serious conditions. For more information https://www.fda.gov/patients/fast-track-breakthrough-therapy-accelerated-approval-priority-review/fast-track" .

<https://w3id.org/biolink/vocab/ApprovalStatusEnum#fda_post_market_safety_review> a owl:Class ;
    rdfs:label "fda_post_market_safety_review" ;
    rdfs:subClassOf biolink:ApprovalStatusEnum,
        linkml:PermissibleValue ;
    skos:definition "FDA Post-Market Safety Monitoring.  The last phase of drug approval is an ongoing one while the drug is on the marketplace. If a developer wants to change anything about the drug formulation or approve it for a new use, they must apply with the FDA. The FDA also frequently reviews the drug’s advertising and its manufacturing facility to make sure everything involved in its creation and marketing is in compliance with regulations." .

<https://w3id.org/biolink/vocab/ApprovalStatusEnum#fda_priority_review> a owl:Class ;
    rdfs:label "fda_priority_review" ;
    rdfs:subClassOf biolink:ApprovalStatusEnum,
        linkml:PermissibleValue ;
    skos:definition "Prior to approval, each drug marketed in the United States must go through a detailed FDA review process. In 1992, under the Prescription Drug User Act (PDUFA), FDA agreed to specific goals for improving the drug review time and created a two-tiered system of review times – Standard Review and Priority Review. A Priority Review designation means FDA’s goal is to take action on an application within 6 months (compared to 10 months under standard review). For more information https://www.fda.gov/patients/fast-track-breakthrough-therapy-accelerated-approval-priority-review/priority-review" .

<https://w3id.org/biolink/vocab/ApprovalStatusEnum#fda_review_phase_4> a owl:Class ;
    rdfs:label "fda_review_phase_4" ;
    rdfs:subClassOf biolink:ApprovalStatusEnum,
        linkml:PermissibleValue ;
    skos:definition "FDA Review" .

<https://w3id.org/biolink/vocab/ApprovalStatusEnum#post_approval_withdrawal> a owl:Class ;
    rdfs:label "post_approval_withdrawal" ;
    rdfs:subClassOf biolink:ApprovalStatusEnum,
        linkml:PermissibleValue .

<https://w3id.org/biolink/vocab/ApprovalStatusEnum#preclinical_research_phase> a owl:Class ;
    rdfs:label "preclinical_research_phase" ;
    rdfs:subClassOf biolink:ApprovalStatusEnum,
        linkml:PermissibleValue ;
    skos:definition "Preclinical Research Phase.  Once researchers have examined the possibilities a new drug may contain, they must do preliminary research to determine its potential for harm (toxicity). This is categorized as preclinical research and can be one of two types: in vitro or in vivo." .

<https://w3id.org/biolink/vocab/ApprovalStatusEnum#regular_fda_approval> a owl:Class ;
    rdfs:label "regular_fda_approval" ;
    rdfs:subClassOf biolink:ApprovalStatusEnum,
        linkml:PermissibleValue ;
    skos:definition "Regular FDA Approval.  The last phase of drug approval is an ongoing one while the drug is on the marketplace. If a developer wants to change anything about the drug formulation or approve it for a new use, they must apply with the FDA. The FDA also frequently reviews the drug’s advertising and its manufacturing facility to make sure everything involved in its creation and marketing is in compliance with regulations." .

<https://w3id.org/biolink/vocab/AssociationBasisEnum#functional> a owl:Class ;
    rdfs:label "functional" ;
    rdfs:subClassOf biolink:AssociationBasisEnum,
        linkml:PermissibleValue ;
    skos:definition "An association based on the participation of two biological entities in a common biological function, process, pathway, reaction, molecular complex, interaction, gene expression program, or other functional system. Functionally associated entities need not interact directly or contribute in the same direction to the shared function; they are related by their involvement in the same biological phenomenon." .

<https://w3id.org/biolink/vocab/AssociationBasisEnum#genetic> a owl:Class ;
    rdfs:label "genetic" ;
    rdfs:subClassOf biolink:AssociationBasisEnum,
        linkml:PermissibleValue ;
    skos:definition "An association based on the relationship of two biological entities through inherited genetic variation. Examples include associations between genetic variants and phenotypes, diseases, traits, gene expression levels, protein abundance, or other molecular or organismal phenotypes. Such associations do not necessarily imply causation or direct biological function and are typically identified through genetic association studies, including genome-wide association studies (GWAS), phenome-wide association studies (PheWAS), and quantitative trait locus (QTL) mapping (e.g., eQTL and pQTL analyses)." .

<https://w3id.org/biolink/vocab/AssociationBasisEnum#statistical> a owl:Class ;
    rdfs:label "statistical" ;
    rdfs:subClassOf biolink:AssociationBasisEnum,
        linkml:PermissibleValue ;
    skos:definition "An association based on statistical dependence (i.e., non-independence), derived from analysis of observational or experimental data using an appropriate statistical method." .

biolink:BehaviorToBehavioralFeatureAssociation a owl:Class ;
    rdfs:label "behavior to behavioral feature association" ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:subject ],
        [ a owl:Restriction ;
            owl:minCardinality 1 ;
            owl:onProperty biolink:subject ],
        [ a owl:Restriction ;
            owl:minCardinality 1 ;
            owl:onProperty biolink:object ],
        [ a owl:Restriction ;
            owl:allValuesFrom biolink:Behavior ;
            owl:onProperty biolink:subject ],
        [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:object ],
        [ a owl:Restriction ;
            owl:onProperty linkml:mixins ;
            owl:someValuesFrom biolink:EntityToPhenotypicFeatureAssociationMixin ],
        [ a owl:Restriction ;
            owl:allValuesFrom biolink:BehavioralFeature ;
            owl:onProperty biolink:object ],
        biolink:Association ;
    skos:definition "An association between an mixture behavior and a behavioral feature manifested by the individual exhibited or has exhibited the behavior." ;
    skos:inScheme biolink: .

biolink:BehavioralExposure a owl:Class ;
    rdfs:label "behavioral exposure" ;
    rdfs:subClassOf biolink:ExposureEvent ;
    skos:definition "A behavioral exposure is a factor relating to behavior impacting an individual." ;
    skos:inScheme biolink: .

<https://w3id.org/biolink/vocab/BinaryRelationEnum#equal_to> a owl:Class ;
    rdfs:label "equal_to" ;
    rdfs:subClassOf biolink:BinaryRelationEnum,
        linkml:PermissibleValue .

<https://w3id.org/biolink/vocab/BinaryRelationEnum#greater_than> a owl:Class ;
    rdfs:label "greater_than" ;
    rdfs:subClassOf biolink:BinaryRelationEnum,
        linkml:PermissibleValue .

<https://w3id.org/biolink/vocab/BinaryRelationEnum#less_than> a owl:Class ;
    rdfs:label "less_than" ;
    rdfs:subClassOf biolink:BinaryRelationEnum,
        linkml:PermissibleValue .

biolink:BiologicalProcessOrActivityToAnatomicalEntityAssociation a owl:Class ;
    rdfs:label "biological process or activity to anatomical entity association" ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:allValuesFrom biolink:AnatomicalEntity ;
            owl:onProperty biolink:object ],
        [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:subject ],
        [ a owl:Restriction ;
            owl:minCardinality 1 ;
            owl:onProperty biolink:subject ],
        [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:object ],
        [ a owl:Restriction ;
            owl:minCardinality 1 ;
            owl:onProperty biolink:object ],
        [ a owl:Restriction ;
            owl:allValuesFrom biolink:BiologicalProcessOrActivity ;
            owl:onProperty biolink:subject ],
        biolink:Association ;
    skos:definition "An association between a biological process or activity and an anatomical entity." ;
    skos:inScheme biolink: .

biolink:BiologicalProcessOrActivityToBiologicalProcessOrActivityAssociation a owl:Class ;
    rdfs:label "biological process or activity to biological process or activity association" ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:minCardinality 1 ;
            owl:onProperty biolink:predicate ],
        [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:subject ],
        [ a owl:Restriction ;
            owl:allValuesFrom xsd:string ;
            owl:onProperty biolink:predicate ],
        [ a owl:Restriction ;
            owl:minCardinality 1 ;
            owl:onProperty biolink:object ],
        [ a owl:Restriction ;
            owl:allValuesFrom biolink:BiologicalProcessOrActivity ;
            owl:onProperty biolink:subject ],
        [ a owl:Restriction ;
            owl:allValuesFrom biolink:BiologicalProcessOrActivity ;
            owl:onProperty biolink:object ],
        [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:predicate ],
        [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:object ],
        [ a owl:Restriction ;
            owl:minCardinality 1 ;
            owl:onProperty biolink:subject ],
        biolink:Association ;
    skos:definition "Classification relationship between biological processes or activities (e.g. coupling of two molecular activities;  assignment of molecular activity to a pathway; implicating a pathway in a biological process; etc.)" ;
    skos:inScheme biolink: .

biolink:BiologicalProcessOrActivityToGeneOrGeneProductOrGeneFamilyAssociation a owl:Class ;
    rdfs:label "biological process or activity to gene or gene product or gene family association" ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:minCardinality 1 ;
            owl:onProperty biolink:predicate ],
        [ a owl:Restriction ;
            owl:allValuesFrom biolink:BiologicalProcessOrActivity ;
            owl:onProperty biolink:subject ],
        [ a owl:Restriction ;
            owl:allValuesFrom biolink:GeneOrGeneProductOrGeneFamily ;
            owl:onProperty biolink:object ],
        [ a owl:Restriction ;
            owl:allValuesFrom xsd:string ;
            owl:onProperty biolink:predicate ],
        [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:predicate ],
        [ a owl:Restriction ;
            owl:minCardinality 1 ;
            owl:onProperty biolink:object ],
        [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:subject ],
        [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:object ],
        [ a owl:Restriction ;
            owl:minCardinality 1 ;
            owl:onProperty biolink:subject ],
        biolink:Association ;
    skos:definition "Relationship between a biological processor activity (e.g. molecular activity, biological process or pathway) to gene or gene product or gene family." ;
    skos:inScheme biolink: .

biolink:BioticExposure a owl:Class ;
    rdfs:label "biotic exposure" ;
    rdfs:subClassOf biolink:ExposureEvent ;
    skos:altLabel "bacterial exposure",
        "viral exposure" ;
    skos:definition "An external biotic exposure is an intake of (sometimes pathological) biological organisms (including viruses)." ;
    skos:inScheme biolink: .

biolink:Book a owl:Class ;
    rdfs:label "book" ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:allValuesFrom xsd:string ;
            owl:onProperty biolink:type ],
        [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:id ],
        [ a owl:Restriction ;
            owl:minCardinality 0 ;
            owl:onProperty biolink:type ],
        [ a owl:Restriction ;
            owl:minCardinality 1 ;
            owl:onProperty biolink:id ],
        [ a owl:Restriction ;
            owl:allValuesFrom xsd:string ;
            owl:onProperty biolink:id ],
        biolink:Publication ;
    skos:definition "This class may rarely be instantiated except if use cases of a given knowledge graph support its utility." ;
    skos:inScheme biolink: .

biolink:CaseToDiseaseAssociation a owl:Class ;
    rdfs:label "case to disease association" ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:allValuesFrom biolink:NamedThing ;
            owl:onProperty biolink:subject ],
        [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:onset_qualifier ],
        [ a owl:Restriction ;
            owl:allValuesFrom xsd:anyURI ;
            owl:onProperty biolink:predicate ],
        [ a owl:Restriction ;
            owl:onProperty linkml:mixins ;
            owl:someValuesFrom biolink:CaseToEntityAssociationMixin ],
        [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:object ],
        [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:predicate ],
        [ a owl:Restriction ;
            owl:minCardinality 0 ;
            owl:onProperty biolink:onset_qualifier ],
        [ a owl:Restriction ;
            owl:minCardinality 1 ;
            owl:onProperty biolink:predicate ],
        [ a owl:Restriction ;
            owl:minCardinality 1 ;
            owl:onProperty biolink:object ],
        [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:subject ],
        [ a owl:Restriction ;
            owl:allValuesFrom biolink:Onset ;
            owl:onProperty biolink:onset_qualifier ],
        [ a owl:Restriction ;
            owl:allValuesFrom biolink:Disease ;
            owl:onProperty biolink:object ],
        [ a owl:Restriction ;
            owl:minCardinality 1 ;
            owl:onProperty biolink:subject ],
        biolink:Association ;
    skos:definition "An association between a Case (patient) and a Disease" ;
    skos:inScheme biolink: .

biolink:CaseToGeneAssociation a owl:Class ;
    rdfs:label "case to gene association" ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:onProperty linkml:mixins ;
            owl:someValuesFrom biolink:CaseToEntityAssociationMixin ],
        [ a owl:Restriction ;
            owl:allValuesFrom xsd:anyURI ;
            owl:onProperty biolink:predicate ],
        [ a owl:Restriction ;
            owl:allValuesFrom biolink:NamedThing ;
            owl:onProperty biolink:subject ],
        [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:subject ],
        [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:predicate ],
        [ a owl:Restriction ;
            owl:minCardinality 1 ;
            owl:onProperty biolink:predicate ],
        [ a owl:Restriction ;
            owl:allValuesFrom biolink:GeneOrGeneProduct ;
            owl:onProperty biolink:object ],
        [ a owl:Restriction ;
            owl:minCardinality 1 ;
            owl:onProperty biolink:subject ],
        [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:object ],
        [ a owl:Restriction ;
            owl:minCardinality 1 ;
            owl:onProperty biolink:object ],
        biolink:Association ;
    skos:definition "Association between a Case and a Gene (e.g., indicating a gene of interest for the case)" ;
    skos:inScheme biolink: .

biolink:CaseToPhenotypicFeatureAssociation a owl:Class ;
    rdfs:label "case to phenotypic feature association" ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:negated ],
        [ a owl:Restriction ;
            owl:minCardinality 0 ;
            owl:onProperty biolink:negated ],
        [ a owl:Restriction ;
            owl:allValuesFrom xsd:boolean ;
            owl:onProperty biolink:negated ],
        [ a owl:Restriction ;
            owl:onProperty linkml:mixins ;
            owl:someValuesFrom biolink:EntityToPhenotypicFeatureAssociationMixin ],
        [ a owl:Restriction ;
            owl:minCardinality 0 ;
            owl:onProperty biolink:onset_qualifier ],
        [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:onset_qualifier ],
        [ a owl:Restriction ;
            owl:onProperty linkml:mixins ;
            owl:someValuesFrom biolink:CaseToEntityAssociationMixin ],
        [ a owl:Restriction ;
            owl:allValuesFrom biolink:Onset ;
            owl:onProperty biolink:onset_qualifier ],
        biolink:Association ;
    skos:definition "An association between a case (e.g. individual patient) and a phenotypic feature in which the individual has or has had the phenotype." ;
    skos:inScheme biolink: .

biolink:CaseToVariantAssociation a owl:Class ;
    rdfs:label "case to variant association" ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:minCardinality 0 ;
            owl:onProperty biolink:has_zygosity ],
        [ a owl:Restriction ;
            owl:onProperty linkml:mixins ;
            owl:someValuesFrom biolink:CaseToEntityAssociationMixin ],
        [ a owl:Restriction ;
            owl:minCardinality 1 ;
            owl:onProperty biolink:predicate ],
        [ a owl:Restriction ;
            owl:allValuesFrom xsd:anyURI ;
            owl:onProperty biolink:predicate ],
        [ a owl:Restriction ;
            owl:minCardinality 1 ;
            owl:onProperty biolink:subject ],
        [ a owl:Restriction ;
            owl:allValuesFrom biolink:SequenceVariant ;
            owl:onProperty biolink:object ],
        [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:has_zygosity ],
        [ a owl:Restriction ;
            owl:minCardinality 1 ;
            owl:onProperty biolink:object ],
        [ a owl:Restriction ;
            owl:allValuesFrom biolink:NamedThing ;
            owl:onProperty biolink:subject ],
        [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:object ],
        [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:predicate ],
        [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:subject ],
        [ a owl:Restriction ;
            owl:allValuesFrom biolink:Zygosity ;
            owl:onProperty biolink:has_zygosity ],
        biolink:Association ;
    skos:definition "Association between a Case and a Genetic Variant" ;
    skos:inScheme biolink: .

biolink:CausalGeneToDiseaseAssociation a owl:Class ;
    rdfs:label "causal gene to disease association" ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:minCardinality 0 ;
            owl:onProperty biolink:qualified_predicate ],
        [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:subject_form_or_variant_qualifier ],
        [ a owl:Restriction ;
            owl:allValuesFrom biolink:GeneOrGeneProductOrChemicalEntityAspectEnum ;
            owl:onProperty biolink:subject_aspect_qualifier ],
        [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:object ],
        [ a owl:Restriction ;
            owl:allValuesFrom [ a rdfs:Datatype ;
                    owl:intersectionOf ( xsd:string [ a rdfs:Datatype ;
                                owl:onDatatype xsd:string ;
                                owl:withRestrictions ( [ xsd:pattern "^HP:\\d{7}$" ] ) ] ) ] ;
            owl:onProperty biolink:allelic_requirement ],
        [ a owl:Restriction ;
            owl:minCardinality 0 ;
            owl:onProperty biolink:subject_form_or_variant_qualifier ],
        [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:subject ],
        [ a owl:Restriction ;
            owl:minCardinality 0 ;
            owl:onProperty biolink:subject_aspect_qualifier ],
        [ a owl:Restriction ;
            owl:allValuesFrom biolink:DirectionQualifierEnum ;
            owl:onProperty biolink:object_direction_qualifier ],
        [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:object_direction_qualifier ],
        [ a owl:Restriction ;
            owl:minCardinality 0 ;
            owl:onProperty biolink:object_direction_qualifier ],
        [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:allelic_requirement ],
        [ a owl:Restriction ;
            owl:minCardinality 1 ;
            owl:onProperty biolink:object ],
        [ a owl:Restriction ;
            owl:allValuesFrom xsd:string ;
            owl:onProperty biolink:subject_form_or_variant_qualifier ],
        [ a owl:Restriction ;
            owl:minCardinality 1 ;
            owl:onProperty biolink:subject ],
        [ a owl:Restriction ;
            owl:allValuesFrom biolink:Disease ;
            owl:onProperty biolink:object ],
        [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:subject_aspect_qualifier ],
        [ a owl:Restriction ;
            owl:onProperty linkml:mixins ;
            owl:someValuesFrom biolink:GeneToEntityAssociationMixin ],
        [ a owl:Restriction ;
            owl:allValuesFrom xsd:anyURI ;
            owl:onProperty biolink:qualified_predicate ],
        [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:qualified_predicate ],
        [ a owl:Restriction ;
            owl:minCardinality 0 ;
            owl:onProperty biolink:allelic_requirement ],
        [ a owl:Restriction ;
            owl:allValuesFrom biolink:GeneOrGeneProduct ;
            owl:onProperty biolink:subject ],
        biolink:Association ;
    skos:definition "An association between a gene and a disease where variation in the gene has been shown to have a causal role in the disease." ;
    skos:inScheme biolink: .

<https://w3id.org/biolink/vocab/CausalMechanismQualifierEnum#ADP-ribosylation> a owl:Class ;
    rdfs:label "ADP-ribosylation" ;
    rdfs:subClassOf biolink:CausalMechanismQualifierEnum,
        <https://w3id.org/biolink/vocab/CausalMechanismQualifierEnum#molecular_modification> .

<https://w3id.org/biolink/vocab/CausalMechanismQualifierEnum#acetylation> a owl:Class ;
    rdfs:label "acetylation" ;
    rdfs:subClassOf biolink:CausalMechanismQualifierEnum,
        <https://w3id.org/biolink/vocab/CausalMechanismQualifierEnum#molecular_modification> .

<https://w3id.org/biolink/vocab/CausalMechanismQualifierEnum#adduction> a owl:Class ;
    rdfs:label "adduction" ;
    rdfs:subClassOf biolink:CausalMechanismQualifierEnum,
        <https://w3id.org/biolink/vocab/CausalMechanismQualifierEnum#covalent_binding> ;
    skos:definition "A covalent binding mechanism in which a drug-protein adduct forms by the covalent binding of electrophilic drugs or their reactive metabolite(s) to a target protein." .

<https://w3id.org/biolink/vocab/CausalMechanismQualifierEnum#allosteric_antagonism> a owl:Class ;
    rdfs:label "allosteric_antagonism" ;
    rdfs:subClassOf biolink:CausalMechanismQualifierEnum,
        <https://w3id.org/biolink/vocab/CausalMechanismQualifierEnum#antagonism> ;
    skos:definition "An inhibition mechanism in which the effector binds to a receptor at an allosteric site and prevents activation by a positive allosteric modulator at that site." .

<https://w3id.org/biolink/vocab/CausalMechanismQualifierEnum#ampylation> a owl:Class ;
    rdfs:label "ampylation" ;
    rdfs:subClassOf biolink:CausalMechanismQualifierEnum,
        <https://w3id.org/biolink/vocab/CausalMechanismQualifierEnum#molecular_modification> ;
    skos:definition "A molecular modification involving the addition of an adenylyl (AMP) moiety to a substrate protein residue." .

<https://w3id.org/biolink/vocab/CausalMechanismQualifierEnum#antibody_agonism> a owl:Class ;
    rdfs:label "antibody_agonism" ;
    rdfs:subClassOf biolink:CausalMechanismQualifierEnum,
        <https://w3id.org/biolink/vocab/CausalMechanismQualifierEnum#agonism> ;
    skos:definition "An agonism mechanism in which the effector is an antobody that binds and activates a receptor to mimic the effect of an endogenous ligand." .

<https://w3id.org/biolink/vocab/CausalMechanismQualifierEnum#antibody_inhibition> a owl:Class ;
    rdfs:label "antibody_inhibition" ;
    rdfs:subClassOf biolink:CausalMechanismQualifierEnum,
        <https://w3id.org/biolink/vocab/CausalMechanismQualifierEnum#inhibition> ;
    skos:definition "An inhibition mechanism in which an antibody effector specifically binds to and interferes with the target." .

<https://w3id.org/biolink/vocab/CausalMechanismQualifierEnum#antisense_oligonucleotide_inhibition> a owl:Class ;
    rdfs:label "antisense_oligonucleotide_inhibition" ;
    rdfs:subClassOf biolink:CausalMechanismQualifierEnum,
        <https://w3id.org/biolink/vocab/CausalMechanismQualifierEnum#negative_modulation> ;
    skos:definition "A negative modulation mechanism in which an antisense oligonucleotide effector prevents translation of a complementary mRNA sequence through binding and targeting it for degradation. Note that while this is called \"inhibition', it is not inhibition in the classic biochemical sense that requires a direct interaction between effector and target." .

<https://w3id.org/biolink/vocab/CausalMechanismQualifierEnum#atpase_activation> a owl:Class ;
    rdfs:label "atpase_activation" ;
    rdfs:subClassOf biolink:CausalMechanismQualifierEnum,
        <https://w3id.org/biolink/vocab/CausalMechanismQualifierEnum#negative_modulation> ;
    skos:definition "An activation mechanism in which the effector accelerates the intrinsic ATPase activity of a target protein, promoting the conversion of the active, ATP-bound form to the inactive, ADP-bound form, thereby terminating a signaling event. Note that this is a negative modulation mechanism because the target is the protein whose activity is attenuated through atpase activation." .

<https://w3id.org/biolink/vocab/CausalMechanismQualifierEnum#biased_agonism> a owl:Class ;
    rdfs:label "biased_agonism" ;
    rdfs:subClassOf biolink:CausalMechanismQualifierEnum,
        <https://w3id.org/biolink/vocab/CausalMechanismQualifierEnum#agonism> ;
    skos:definition "An agonism mechanism in which the effector  binds to a receptor and activates certain signaling pathways while ignoring others, allowing it to produce a desired effect without unwanted side effects." .

<https://w3id.org/biolink/vocab/CausalMechanismQualifierEnum#binding> a owl:Class ;
    rdfs:label "binding" ;
    rdfs:subClassOf biolink:CausalMechanismQualifierEnum,
        <https://w3id.org/biolink/vocab/CausalMechanismQualifierEnum#modulation> ;
    skos:definition "A modulation mechanism mediated by the direct contact between effector and target chemical or biomolecular entity, which form a stable physical interaction (typically non-covalent)." .

<https://w3id.org/biolink/vocab/CausalMechanismQualifierEnum#biphasic_allosteric_modulation> a owl:Class ;
    rdfs:label "biphasic_allosteric_modulation" ;
    rdfs:subClassOf biolink:CausalMechanismQualifierEnum,
        <https://w3id.org/biolink/vocab/CausalMechanismQualifierEnum#mixed_allosteric_modulation> ;
    skos:definition "A mixed allosteric modulation mechanism that occurs when a chemical exerts an activating effect at lower concentrations, and an inhibitory effect at higher concentrations." .

<https://w3id.org/biolink/vocab/CausalMechanismQualifierEnum#carboxylation> a owl:Class ;
    rdfs:label "carboxylation" ;
    rdfs:subClassOf biolink:CausalMechanismQualifierEnum,
        <https://w3id.org/biolink/vocab/CausalMechanismQualifierEnum#molecular_modification> .

<https://w3id.org/biolink/vocab/CausalMechanismQualifierEnum#catalytic_activity> a owl:Class ;
    rdfs:label "catalytic_activity" ;
    rdfs:subClassOf biolink:CausalMechanismQualifierEnum,
        <https://w3id.org/biolink/vocab/CausalMechanismQualifierEnum#modulation> ;
    skos:definition "A modulation mechanism mediated by through the catalytic activity of the effector on the target." .

<https://w3id.org/biolink/vocab/CausalMechanismQualifierEnum#chaperone_mediated_stabilization> a owl:Class ;
    rdfs:label "chaperone_mediated_stabilization" ;
    rdfs:subClassOf biolink:CausalMechanismQualifierEnum,
        <https://w3id.org/biolink/vocab/CausalMechanismQualifierEnum#stabilization> .

<https://w3id.org/biolink/vocab/CausalMechanismQualifierEnum#chelation> a owl:Class ;
    rdfs:label "chelation" ;
    rdfs:subClassOf biolink:CausalMechanismQualifierEnum,
        <https://w3id.org/biolink/vocab/CausalMechanismQualifierEnum#modulation> ;
    skos:definition "A modulation mechanism in which an effector binds to a metal ion target, reducing its availability/reactivity for further interactions." .

<https://w3id.org/biolink/vocab/CausalMechanismQualifierEnum#chemical_modification> a owl:Class ;
    rdfs:label "chemical_modification" ;
    rdfs:subClassOf biolink:CausalMechanismQualifierEnum,
        <https://w3id.org/biolink/vocab/CausalMechanismQualifierEnum#modulation> ;
    skos:definition "A modulation mechanism mediated by a protein/complex effector altering a small molecule by modifying it or converting it to something else." .

<https://w3id.org/biolink/vocab/CausalMechanismQualifierEnum#cleavage> a owl:Class ;
    rdfs:label "cleavage" ;
    rdfs:subClassOf biolink:CausalMechanismQualifierEnum,
        <https://w3id.org/biolink/vocab/CausalMechanismQualifierEnum#modulation> ;
    skos:definition "A modulation mechanism in which an effector promotes degeneration of the target protein through cleaving of the peptide bonds." .

<https://w3id.org/biolink/vocab/CausalMechanismQualifierEnum#cofactor> a owl:Class ;
    rdfs:label "cofactor" ;
    rdfs:subClassOf biolink:CausalMechanismQualifierEnum,
        <https://w3id.org/biolink/vocab/CausalMechanismQualifierEnum#positive_modulation> ;
    skos:definition "A positive modulation mechanism in which the effector (usually some non-protein chemical compound or metallic ion) is required for a target enzyme's biological/catalytic activity." .

<https://w3id.org/biolink/vocab/CausalMechanismQualifierEnum#competitive_inhibition> a owl:Class ;
    rdfs:label "competitive_inhibition" ;
    rdfs:subClassOf biolink:CausalMechanismQualifierEnum,
        <https://w3id.org/biolink/vocab/CausalMechanismQualifierEnum#inhibition> ;
    skos:definition "An inhibition mechanism in which the effector binds to a target molecule (such as an enzyme) and prevents the binding of a substrate (or another binding partner) and vice versa." .

<https://w3id.org/biolink/vocab/CausalMechanismQualifierEnum#crosslinking> a owl:Class ;
    rdfs:label "crosslinking" ;
    rdfs:subClassOf biolink:CausalMechanismQualifierEnum,
        <https://w3id.org/biolink/vocab/CausalMechanismQualifierEnum#covalent_binding> ;
    skos:definition "A covalent binding mechanism in which an effector induces cross-linking of target proteins or nucleic acids - covalently joining them into a rigid structure." .

<https://w3id.org/biolink/vocab/CausalMechanismQualifierEnum#de-ADP-ribosylation> a owl:Class ;
    rdfs:label "de-ADP-ribosylation" ;
    rdfs:subClassOf biolink:CausalMechanismQualifierEnum,
        <https://w3id.org/biolink/vocab/CausalMechanismQualifierEnum#molecular_modification> .

<https://w3id.org/biolink/vocab/CausalMechanismQualifierEnum#deacetylation> a owl:Class ;
    rdfs:label "deacetylation" ;
    rdfs:subClassOf biolink:CausalMechanismQualifierEnum,
        <https://w3id.org/biolink/vocab/CausalMechanismQualifierEnum#molecular_modification> .

<https://w3id.org/biolink/vocab/CausalMechanismQualifierEnum#deglycosylation> a owl:Class ;
    rdfs:label "deglycosylation" ;
    rdfs:subClassOf biolink:CausalMechanismQualifierEnum,
        <https://w3id.org/biolink/vocab/CausalMechanismQualifierEnum#molecular_modification> .

<https://w3id.org/biolink/vocab/CausalMechanismQualifierEnum#degradation> a owl:Class ;
    rdfs:label "degradation" ;
    rdfs:subClassOf biolink:CausalMechanismQualifierEnum,
        <https://w3id.org/biolink/vocab/CausalMechanismQualifierEnum#modulation> ;
    skos:definition "A modulation mechanism that controls protein and cellular component levels through the regulated breakdown and recycling of molecules." .

<https://w3id.org/biolink/vocab/CausalMechanismQualifierEnum#demethylation> a owl:Class ;
    rdfs:label "demethylation" ;
    rdfs:subClassOf biolink:CausalMechanismQualifierEnum,
        <https://w3id.org/biolink/vocab/CausalMechanismQualifierEnum#molecular_modification> .

<https://w3id.org/biolink/vocab/CausalMechanismQualifierEnum#deneddylation> a owl:Class ;
    rdfs:label "deneddylation" ;
    rdfs:subClassOf biolink:CausalMechanismQualifierEnum,
        <https://w3id.org/biolink/vocab/CausalMechanismQualifierEnum#molecular_modification> .

<https://w3id.org/biolink/vocab/CausalMechanismQualifierEnum#dephosphorylation> a owl:Class ;
    rdfs:label "dephosphorylation" ;
    rdfs:subClassOf biolink:CausalMechanismQualifierEnum,
        <https://w3id.org/biolink/vocab/CausalMechanismQualifierEnum#molecular_modification> .

<https://w3id.org/biolink/vocab/CausalMechanismQualifierEnum#destabilization> a owl:Class ;
    rdfs:label "destabilization" ;
    rdfs:subClassOf biolink:CausalMechanismQualifierEnum,
        <https://w3id.org/biolink/vocab/CausalMechanismQualifierEnum#modulation> ;
    skos:definition "A modulation mechanism in which a chaperone molecule directly binds to a partially folded biosynthetic intermediate to stabilize the protein and allow it to complete the folding process to yield a functional protein." .

<https://w3id.org/biolink/vocab/CausalMechanismQualifierEnum#desumoylation> a owl:Class ;
    rdfs:label "desumoylation" ;
    rdfs:subClassOf biolink:CausalMechanismQualifierEnum,
        <https://w3id.org/biolink/vocab/CausalMechanismQualifierEnum#molecular_modification> .

<https://w3id.org/biolink/vocab/CausalMechanismQualifierEnum#deubiquitination> a owl:Class ;
    rdfs:label "deubiquitination" ;
    rdfs:subClassOf biolink:CausalMechanismQualifierEnum,
        <https://w3id.org/biolink/vocab/CausalMechanismQualifierEnum#molecular_modification> .

<https://w3id.org/biolink/vocab/CausalMechanismQualifierEnum#disruption> a owl:Class ;
    rdfs:label "disruption" ;
    rdfs:subClassOf biolink:CausalMechanismQualifierEnum,
        <https://w3id.org/biolink/vocab/CausalMechanismQualifierEnum#modulation> ;
    skos:definition "A modulation mechanism in which an effector destabilizes or disrupts a protein complex, macromolecular assembly, cell membrane etc." .

<https://w3id.org/biolink/vocab/CausalMechanismQualifierEnum#disuphide_binding> a owl:Class ;
    rdfs:label "disuphide_binding" ;
    rdfs:subClassOf biolink:CausalMechanismQualifierEnum,
        <https://w3id.org/biolink/vocab/CausalMechanismQualifierEnum#covalent_binding> ;
    skos:definition "A covalent binding mechanism involving a covalent bond formed between two cysteine residues in or between proteins." .

<https://w3id.org/biolink/vocab/CausalMechanismQualifierEnum#exogenous_gene> a owl:Class ;
    rdfs:label "exogenous_gene" ;
    rdfs:subClassOf biolink:CausalMechanismQualifierEnum,
        <https://w3id.org/biolink/vocab/CausalMechanismQualifierEnum#modulation> ;
    skos:definition "A modulation mechanism in which a nucleic acid from an exogenous source acts as a substitute or supplement for a specific gene which is absent or has reduced function in an affected target/subject." .

<https://w3id.org/biolink/vocab/CausalMechanismQualifierEnum#exogenous_protein> a owl:Class ;
    rdfs:label "exogenous_protein" ;
    rdfs:subClassOf biolink:CausalMechanismQualifierEnum,
        <https://w3id.org/biolink/vocab/CausalMechanismQualifierEnum#modulation> ;
    skos:definition "A modulation mechanism in which a protein from an exogenous source acts as a substitute or supplement for a specific protein which is absent or has reduced function in an affected target/subject." .

<https://w3id.org/biolink/vocab/CausalMechanismQualifierEnum#feedback_inhibition> a owl:Class ;
    rdfs:label "feedback_inhibition" ;
    rdfs:subClassOf biolink:CausalMechanismQualifierEnum,
        <https://w3id.org/biolink/vocab/CausalMechanismQualifierEnum#negative_modulation> ;
    skos:definition "An negative modulation mechanism in which the end product of a metabolic pathway inhibits an enzyme early in that same pathway, which stops the production of the final product when it's no longer needed." .

<https://w3id.org/biolink/vocab/CausalMechanismQualifierEnum#gating_inhibition> a owl:Class ;
    rdfs:label "gating_inhibition" ;
    rdfs:subClassOf biolink:CausalMechanismQualifierEnum,
        <https://w3id.org/biolink/vocab/CausalMechanismQualifierEnum#inhibition> ;
    skos:definition "An inhibition mechanism mediated by the transition of ion channels between their open (conducting) and closed (non-conducting) conformational states." .

<https://w3id.org/biolink/vocab/CausalMechanismQualifierEnum#glycosylation> a owl:Class ;
    rdfs:label "glycosylation" ;
    rdfs:subClassOf biolink:CausalMechanismQualifierEnum,
        <https://w3id.org/biolink/vocab/CausalMechanismQualifierEnum#molecular_modification> .

<https://w3id.org/biolink/vocab/CausalMechanismQualifierEnum#gtpase_activation> a owl:Class ;
    rdfs:label "gtpase_activation" ;
    rdfs:subClassOf biolink:CausalMechanismQualifierEnum,
        <https://w3id.org/biolink/vocab/CausalMechanismQualifierEnum#negative_modulation> ;
    skos:definition "An activation mechanism in which the effector accelerates the intrinsic GTPase activity of a G-protein, promoting the conversion of the active, GTP-bound form to the inactive, GDP-bound form, thereby terminating a signaling event. Note that this is a negative modulation mechanism because the target is the G-protein whose activity is attenuated through gtpase activation." .

<https://w3id.org/biolink/vocab/CausalMechanismQualifierEnum#guanyl_nucleotide_exchange> a owl:Class ;
    rdfs:label "guanyl_nucleotide_exchange" ;
    rdfs:subClassOf biolink:CausalMechanismQualifierEnum,
        <https://w3id.org/biolink/vocab/CausalMechanismQualifierEnum#activation> ;
    skos:definition "An activation mechanism in which the effector catalyzes the exchange of guanosine diphosphate (GDP) for guanosine triphosphate (GTP) in a guanine nucleotide-binding protein (G-protein)." .

<https://w3id.org/biolink/vocab/CausalMechanismQualifierEnum#hydrolysis> a owl:Class ;
    rdfs:label "hydrolysis" ;
    rdfs:subClassOf biolink:CausalMechanismQualifierEnum,
        <https://w3id.org/biolink/vocab/CausalMechanismQualifierEnum#modulation> ;
    skos:definition "A modulation mechanism in which an effector cleaves its target through a chemical reaction where a molecule of water is used to break a bond." .

<https://w3id.org/biolink/vocab/CausalMechanismQualifierEnum#hydroxylation> a owl:Class ;
    rdfs:label "hydroxylation" ;
    rdfs:subClassOf biolink:CausalMechanismQualifierEnum,
        <https://w3id.org/biolink/vocab/CausalMechanismQualifierEnum#molecular_modification> .

<https://w3id.org/biolink/vocab/CausalMechanismQualifierEnum#induction> a owl:Class ;
    rdfs:label "induction" ;
    rdfs:subClassOf biolink:CausalMechanismQualifierEnum,
        <https://w3id.org/biolink/vocab/CausalMechanismQualifierEnum#positive_modulation> ;
    skos:closeMatch DGIdb:inducer ;
    skos:definition "A positive modulation mechanism in which the effector binds to and increases the activity/rate of an enzyme that processes drugs in the body." .

<https://w3id.org/biolink/vocab/CausalMechanismQualifierEnum#inverse_agonism> a owl:Class ;
    rdfs:label "inverse_agonism" ;
    rdfs:subClassOf biolink:CausalMechanismQualifierEnum,
        <https://w3id.org/biolink/vocab/CausalMechanismQualifierEnum#inhibition> ;
    skos:closeMatch DGIdb:inverse_agonist,
        CHEMBL.MECHANISM:inverse_agonist ;
    skos:definition "An inhibition mechanism in which the effector binds to the same receptor-binding site as an agonist and antagonizes its effects, often exerting the opposite effect of the agonist by suppressing spontaneous receptor signaling." .

<https://w3id.org/biolink/vocab/CausalMechanismQualifierEnum#irreversible_inhibition> a owl:Class ;
    rdfs:label "irreversible_inhibition" ;
    rdfs:subClassOf biolink:CausalMechanismQualifierEnum,
        <https://w3id.org/biolink/vocab/CausalMechanismQualifierEnum#inhibition> ;
    skos:definition "An inhibition mechanism in which an effector permanently binds to a target, permanently disrupting its activity." .

<https://w3id.org/biolink/vocab/CausalMechanismQualifierEnum#isomerization> a owl:Class ;
    rdfs:label "isomerization" ;
    rdfs:subClassOf biolink:CausalMechanismQualifierEnum,
        <https://w3id.org/biolink/vocab/CausalMechanismQualifierEnum#modulation> ;
    skos:definition "A modulation mechanism mediated by an effector that alters the isomeric conformation of a target." .

<https://w3id.org/biolink/vocab/CausalMechanismQualifierEnum#mixed_agonism> a owl:Class ;
    rdfs:label "mixed_agonism" ;
    rdfs:subClassOf biolink:CausalMechanismQualifierEnum,
        <https://w3id.org/biolink/vocab/CausalMechanismQualifierEnum#modulation> ;
    skos:definition "An modulation mechanism in which the effector acts as both an agonist (activating a receptor) and an antagonist (blocking a receptor) at different receptor sites." .

<https://w3id.org/biolink/vocab/CausalMechanismQualifierEnum#molecular_channel_blockage> a owl:Class ;
    rdfs:label "molecular_channel_blockage" ;
    rdfs:subClassOf biolink:CausalMechanismQualifierEnum,
        <https://w3id.org/biolink/vocab/CausalMechanismQualifierEnum#inhibition> ;
    skos:definition "An inhibition mechanism in which the effector binds to a molecular channel and prevents or reduces transport of ions through it." .

<https://w3id.org/biolink/vocab/CausalMechanismQualifierEnum#molecular_channel_opening> a owl:Class ;
    rdfs:label "molecular_channel_opening" ;
    rdfs:subClassOf biolink:CausalMechanismQualifierEnum,
        <https://w3id.org/biolink/vocab/CausalMechanismQualifierEnum#activation> ;
    skos:closeMatch CHEMBL.MECHANISM:opener ;
    skos:definition "An activation mechanism in which the effector binds to a molecular channel and facilitates transport of ions through it." .

<https://w3id.org/biolink/vocab/CausalMechanismQualifierEnum#monoubiquitination> a owl:Class ;
    rdfs:label "monoubiquitination" ;
    rdfs:subClassOf biolink:CausalMechanismQualifierEnum,
        <https://w3id.org/biolink/vocab/CausalMechanismQualifierEnum#ubiquitination> .

<https://w3id.org/biolink/vocab/CausalMechanismQualifierEnum#multitarget_modulation> a owl:Class ;
    rdfs:label "multitarget_modulation" ;
    rdfs:subClassOf biolink:CausalMechanismQualifierEnum,
        <https://w3id.org/biolink/vocab/CausalMechanismQualifierEnum#modulation> ;
    skos:definition "A modulation mechanism in which an effector achieves a physiological effect through simultaneous interaction with multiple gene targets." .

<https://w3id.org/biolink/vocab/CausalMechanismQualifierEnum#myristoylation> a owl:Class ;
    rdfs:label "myristoylation" ;
    rdfs:subClassOf biolink:CausalMechanismQualifierEnum,
        <https://w3id.org/biolink/vocab/CausalMechanismQualifierEnum#lipidation> .

<https://w3id.org/biolink/vocab/CausalMechanismQualifierEnum#neddylation> a owl:Class ;
    rdfs:label "neddylation" ;
    rdfs:subClassOf biolink:CausalMechanismQualifierEnum,
        <https://w3id.org/biolink/vocab/CausalMechanismQualifierEnum#molecular_modification> .

<https://w3id.org/biolink/vocab/CausalMechanismQualifierEnum#negative_allosteric_modulation> a owl:Class ;
    rdfs:label "negative_allosteric_modulation" ;
    rdfs:subClassOf biolink:CausalMechanismQualifierEnum,
        <https://w3id.org/biolink/vocab/CausalMechanismQualifierEnum#noncompetitive_inhibition> ;
    skos:closeMatch DGIdb:inhibitory_allosteric_modulator,
        CHEMBL.MECHANISM:negative_allosteric_modulator ;
    skos:definition "A noncompetitive inhibition mechanism in which the effector reduces or prevents the action of the endogenous ligand of a receptor by binding to a site distinct from that ligand, and causing a conformational change that affects ligand binding." .

<https://w3id.org/biolink/vocab/CausalMechanismQualifierEnum#negative_gene_editing_modulation> a owl:Class ;
    rdfs:label "negative_gene_editing_modulation" ;
    rdfs:subClassOf biolink:CausalMechanismQualifierEnum,
        <https://w3id.org/biolink/vocab/CausalMechanismQualifierEnum#negative_modulation> ;
    skos:definition "A negative modulation mechanism in which the effector elicits the negative modulation of its target through a gene editing activity." .

<https://w3id.org/biolink/vocab/CausalMechanismQualifierEnum#non_competitive_antagonism> a owl:Class ;
    rdfs:label "non_competitive_antagonism" ;
    rdfs:subClassOf biolink:CausalMechanismQualifierEnum,
        <https://w3id.org/biolink/vocab/CausalMechanismQualifierEnum#antagonism> ;
    skos:definition "An inhibition mechanism in which the effector binds a site distinct from the agonist's binding site (non-orthosteric), or irreversibly/insurmountably inactivates the receptor - reduces the receptor’s maximal response (Emax) in a way that cannot be overcome by adding more agonist." .

<https://w3id.org/biolink/vocab/CausalMechanismQualifierEnum#opening> a owl:Class ;
    rdfs:label "opening" ;
    rdfs:subClassOf biolink:CausalMechanismQualifierEnum,
        <https://w3id.org/biolink/vocab/CausalMechanismQualifierEnum#modulation> ;
    skos:definition "A modulation mechanism in which an effector positively effects the normal functioning of an ion channel e.g., facilitates transport of ions through the channel." .

<https://w3id.org/biolink/vocab/CausalMechanismQualifierEnum#oxidation> a owl:Class ;
    rdfs:label "oxidation" ;
    rdfs:subClassOf biolink:CausalMechanismQualifierEnum,
        <https://w3id.org/biolink/vocab/CausalMechanismQualifierEnum#molecular_modification> ;
    skos:definition "A molecular modification mechanism in which an effector modifies a target substrate via an oxidation reaction." .

<https://w3id.org/biolink/vocab/CausalMechanismQualifierEnum#oxidoreduction> a owl:Class ;
    rdfs:label "oxidoreduction" ;
    rdfs:subClassOf biolink:CausalMechanismQualifierEnum,
        <https://w3id.org/biolink/vocab/CausalMechanismQualifierEnum#modulation> ;
    skos:definition "A modulation mechanism in which in which electrons are transferred between molecules catalyzed by an oxidoreductase enzyme." .

<https://w3id.org/biolink/vocab/CausalMechanismQualifierEnum#palmitoylation> a owl:Class ;
    rdfs:label "palmitoylation" ;
    rdfs:subClassOf biolink:CausalMechanismQualifierEnum,
        <https://w3id.org/biolink/vocab/CausalMechanismQualifierEnum#lipidation> .

<https://w3id.org/biolink/vocab/CausalMechanismQualifierEnum#partial_agonism> a owl:Class ;
    rdfs:label "partial_agonism" ;
    rdfs:subClassOf biolink:CausalMechanismQualifierEnum,
        <https://w3id.org/biolink/vocab/CausalMechanismQualifierEnum#agonism> ;
    skos:definition "An agonism mechanism in which the effector binds to and only partially activates a receptor (relative to the response to a full agonist)" .

<https://w3id.org/biolink/vocab/CausalMechanismQualifierEnum#phosphorylation> a owl:Class ;
    rdfs:label "phosphorylation" ;
    rdfs:subClassOf biolink:CausalMechanismQualifierEnum,
        <https://w3id.org/biolink/vocab/CausalMechanismQualifierEnum#molecular_modification> .

<https://w3id.org/biolink/vocab/CausalMechanismQualifierEnum#polyubiquitination> a owl:Class ;
    rdfs:label "polyubiquitination" ;
    rdfs:subClassOf biolink:CausalMechanismQualifierEnum,
        <https://w3id.org/biolink/vocab/CausalMechanismQualifierEnum#ubiquitination> .

<https://w3id.org/biolink/vocab/CausalMechanismQualifierEnum#positive_allosteric_modulation> a owl:Class ;
    rdfs:label "positive_allosteric_modulation" ;
    rdfs:subClassOf biolink:CausalMechanismQualifierEnum,
        <https://w3id.org/biolink/vocab/CausalMechanismQualifierEnum#activation> ;
    skos:broadMatch DGIdb:allosteric_modulator,
        DGIdb:modulator ;
    skos:closeMatch DGIdb:positive_allosteric_modulator,
        CHEMBL.MECHANISM:positive_allosteric_modulator,
        CHEMBL.MECHANISM:positive_modulator ;
    skos:definition "A positive modulation mechanism in which the effector enhances the action of the endogenous ligand of a receptor by binding to a site distinct from that ligand (i.e. non-competitive inhibition)" .

<https://w3id.org/biolink/vocab/CausalMechanismQualifierEnum#post_transcriptional_regulation> a owl:Class ;
    rdfs:label "post_transcriptional_regulation" ;
    rdfs:subClassOf biolink:CausalMechanismQualifierEnum,
        <https://w3id.org/biolink/vocab/CausalMechanismQualifierEnum#modulation> ;
    skos:definition "A modulation mechanism which controls expression of a target gene at the RNA level after a gene has been transcribed into messenger RNA (mRNA)." .

<https://w3id.org/biolink/vocab/CausalMechanismQualifierEnum#potentiation> a owl:Class ;
    rdfs:label "potentiation" ;
    rdfs:subClassOf biolink:CausalMechanismQualifierEnum,
        <https://w3id.org/biolink/vocab/CausalMechanismQualifierEnum#positive_modulation> ;
    skos:definition "A positive modulation mechanism in which the effector binds to and enhances or intensifies the effect of some other chemical or drug on its target." .

<https://w3id.org/biolink/vocab/CausalMechanismQualifierEnum#reduction> a owl:Class ;
    rdfs:label "reduction" ;
    rdfs:subClassOf biolink:CausalMechanismQualifierEnum,
        <https://w3id.org/biolink/vocab/CausalMechanismQualifierEnum#molecular_modification> ;
    skos:definition "A molecular modification mechanism in which an effector modifies a target substrate via a reduction reaction." .

<https://w3id.org/biolink/vocab/CausalMechanismQualifierEnum#release> a owl:Class ;
    rdfs:label "release" ;
    rdfs:subClassOf biolink:CausalMechanismQualifierEnum,
        <https://w3id.org/biolink/vocab/CausalMechanismQualifierEnum#modulation> ;
    skos:closeMatch <CHEMBL:MECHANISM:releasing_agent> ;
    skos:definition "A modulation mechanism in which an effector reverses the normal functioning of a transporter, causing release of the substrate, rather than uptake" .

<https://w3id.org/biolink/vocab/CausalMechanismQualifierEnum#relocalization> a owl:Class ;
    rdfs:label "relocalization" ;
    rdfs:subClassOf biolink:CausalMechanismQualifierEnum,
        <https://w3id.org/biolink/vocab/CausalMechanismQualifierEnum#modulation> ;
    skos:definition "A modulation mechanism mediated by an effector that alters the localization of a target in the cell or body." .

<https://w3id.org/biolink/vocab/CausalMechanismQualifierEnum#rna_interference_inhibition> a owl:Class ;
    rdfs:label "rna_interference_inhibition" ;
    rdfs:subClassOf biolink:CausalMechanismQualifierEnum,
        <https://w3id.org/biolink/vocab/CausalMechanismQualifierEnum#negative_modulation> ;
    skos:definition "A negative modulation mechanism in which an effector small interfering RNA (siRNA) molecule finds and destroys messenger RNA (mRNA) with a complementary sequence, preventing a specific gene from being translated into a protein. Note that while this is called \"inhibition', it is not inhibition in the classic biochemical sense that requires a direct interaction between effector and target." .

<https://w3id.org/biolink/vocab/CausalMechanismQualifierEnum#s_nitrosylation> a owl:Class ;
    rdfs:label "s_nitrosylation" ;
    rdfs:subClassOf biolink:CausalMechanismQualifierEnum,
        <https://w3id.org/biolink/vocab/CausalMechanismQualifierEnum#molecular_modification> .

<https://w3id.org/biolink/vocab/CausalMechanismQualifierEnum#sequestration> a owl:Class ;
    rdfs:label "sequestration" ;
    rdfs:subClassOf biolink:CausalMechanismQualifierEnum,
        <https://w3id.org/biolink/vocab/CausalMechanismQualifierEnum#modulation> ;
    skos:definition "A modulation mechanism in which an effector binds to a substance such as a drug, toxin or metabolite and reduces its availability for further interactions." .

<https://w3id.org/biolink/vocab/CausalMechanismQualifierEnum#signaling_mediated_control> a owl:Class ;
    rdfs:label "signaling_mediated_control" ;
    rdfs:subClassOf biolink:CausalMechanismQualifierEnum,
        <https://w3id.org/biolink/vocab/CausalMechanismQualifierEnum#modulation> ;
    skos:definition "A modulation mechanism mediated by the activation or control of signaling events that influence the some aspect of the target entity (e.g. its activity, processing, transport, etc.)." .

<https://w3id.org/biolink/vocab/CausalMechanismQualifierEnum#stimulation> a owl:Class ;
    rdfs:label "stimulation" ;
    rdfs:subClassOf biolink:CausalMechanismQualifierEnum,
        <https://w3id.org/biolink/vocab/CausalMechanismQualifierEnum#activation> ;
    skos:closeMatch SEMMEDDB:STIMULATES,
        DGIdb:stimulator ;
    skos:definition "An activation mechanism in which the effector directly or indirectly affects its target, stimulating a physiological response." .

<https://w3id.org/biolink/vocab/CausalMechanismQualifierEnum#sulfation> a owl:Class ;
    rdfs:label "sulfation" ;
    rdfs:subClassOf biolink:CausalMechanismQualifierEnum,
        <https://w3id.org/biolink/vocab/CausalMechanismQualifierEnum#molecular_modification> .

<https://w3id.org/biolink/vocab/CausalMechanismQualifierEnum#sumoylation> a owl:Class ;
    rdfs:label "sumoylation" ;
    rdfs:subClassOf biolink:CausalMechanismQualifierEnum,
        <https://w3id.org/biolink/vocab/CausalMechanismQualifierEnum#molecular_modification> .

<https://w3id.org/biolink/vocab/CausalMechanismQualifierEnum#suppression> a owl:Class ;
    rdfs:label "suppression" ;
    rdfs:subClassOf biolink:CausalMechanismQualifierEnum,
        <https://w3id.org/biolink/vocab/CausalMechanismQualifierEnum#negative_modulation> ;
    skos:definition "A negative modulation mechanism in which the effector directly or indirectly affects its target, suppressing a physiological process." .

<https://w3id.org/biolink/vocab/CausalMechanismQualifierEnum#transcriptional_regulation> a owl:Class ;
    rdfs:label "transcriptional_regulation" ;
    rdfs:subClassOf biolink:CausalMechanismQualifierEnum,
        <https://w3id.org/biolink/vocab/CausalMechanismQualifierEnum#modulation> ;
    skos:definition "A modulation mechanism mediated by through the control of target gene transcription." .

<https://w3id.org/biolink/vocab/CausalMechanismQualifierEnum#transglutamination> a owl:Class ;
    rdfs:label "transglutamination" ;
    rdfs:subClassOf biolink:CausalMechanismQualifierEnum,
        <https://w3id.org/biolink/vocab/CausalMechanismQualifierEnum#covalent_binding> ;
    skos:definition "A covalent binding mechanism involving formation of a covalent bond between a glutamine residue and an amine as catalyzed by a transglutaminase." .

<https://w3id.org/biolink/vocab/CausalMechanismQualifierEnum#translational_regulation> a owl:Class ;
    rdfs:label "translational_regulation" ;
    rdfs:subClassOf biolink:CausalMechanismQualifierEnum,
        <https://w3id.org/biolink/vocab/CausalMechanismQualifierEnum#modulation> ;
    skos:definition "A modulation mechanism mediated by through the control of target gene translation." .

<https://w3id.org/biolink/vocab/CausalMechanismQualifierEnum#trimethylation> a owl:Class ;
    rdfs:label "trimethylation" ;
    rdfs:subClassOf biolink:CausalMechanismQualifierEnum,
        <https://w3id.org/biolink/vocab/CausalMechanismQualifierEnum#methylation> .

<https://w3id.org/biolink/vocab/CausalMechanismQualifierEnum#tyrosination> a owl:Class ;
    rdfs:label "tyrosination" ;
    rdfs:subClassOf biolink:CausalMechanismQualifierEnum,
        <https://w3id.org/biolink/vocab/CausalMechanismQualifierEnum#molecular_modification> .

<https://w3id.org/biolink/vocab/CausalMechanismQualifierEnum#vaccine_antigen> a owl:Class ;
    rdfs:label "vaccine_antigen" ;
    rdfs:subClassOf biolink:CausalMechanismQualifierEnum,
        <https://w3id.org/biolink/vocab/CausalMechanismQualifierEnum#immune_system_modulation> ;
    skos:definition "An immune system modulation mechanism in which a vaccine mediates its effect through the activation of the immune system against the target." .

biolink:Cell a owl:Class ;
    rdfs:label "cell" ;
    rdfs:subClassOf biolink:AnatomicalEntity ;
    skos:definition "The basic structural and functional unit of all organisms. Includes the plasma membrane and any external encapsulating structures such as the cell wall and cell envelope." ;
    skos:exactMatch MESH:D002477,
        STY:T025,
        <http://purl.obolibrary.org/obo/CL_0000000>,
        <http://purl.obolibrary.org/obo/GO_0005623>,
        SIO:010001,
        WIKIDATA:Q7868 ;
    skos:inScheme biolink: .

biolink:CellLineAsAModelOfDiseaseAssociation a owl:Class ;
    rdfs:label "cell line as a model of disease association" ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:onProperty linkml:mixins ;
            owl:someValuesFrom biolink:EntityToDiseaseAssociationMixin ],
        [ a owl:Restriction ;
            owl:minCardinality 1 ;
            owl:onProperty biolink:subject ],
        [ a owl:Restriction ;
            owl:onProperty linkml:mixins ;
            owl:someValuesFrom biolink:ModelToDiseaseAssociationMixin ],
        [ a owl:Restriction ;
            owl:allValuesFrom biolink:CellLine ;
            owl:onProperty biolink:subject ],
        [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:subject ],
        biolink:CellLineToDiseaseOrPhenotypicFeatureAssociation ;
    skos:definition "An association in which a cell line - typically derived from an organismal entity with a disease state - serves as a model for that disease in experimental settings." ;
    skos:inScheme biolink: .

biolink:CellLineToEntityAssociationMixin a owl:Class ;
    rdfs:label "cell line to entity association mixin" ;
    rdfs:subClassOf <https://w3id.org/linkml/ClassDefinition#Mixin> ;
    skos:definition "An relationship between a cell line and another entity" ;
    skos:inScheme biolink: .

biolink:ChemicalAffectsGeneAssociation a owl:Class ;
    rdfs:label "chemical affects gene association" ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:allValuesFrom xsd:float ;
            owl:onProperty biolink:dgidb_interaction_score ],
        [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:evidence_count ],
        [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:dgidb_interaction_score ],
        [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:dgidb_evidence_score ],
        [ a owl:Restriction ;
            owl:minCardinality 0 ;
            owl:onProperty biolink:dgidb_interaction_score ],
        [ a owl:Restriction ;
            owl:allValuesFrom xsd:integer ;
            owl:onProperty biolink:dgidb_evidence_score ],
        [ a owl:Restriction ;
            owl:minCardinality 0 ;
            owl:onProperty biolink:evidence_count ],
        [ a owl:Restriction ;
            owl:allValuesFrom xsd:integer ;
            owl:onProperty biolink:evidence_count ],
        [ a owl:Restriction ;
            owl:allValuesFrom xsd:anyURI ;
            owl:onProperty biolink:supporting_documents ],
        [ a owl:Restriction ;
            owl:minCardinality 0 ;
            owl:onProperty biolink:supporting_documents ],
        [ a owl:Restriction ;
            owl:minCardinality 0 ;
            owl:onProperty biolink:dgidb_evidence_score ],
        biolink:ChemicalAffectsBiologicalEntityAssociation ;
    skos:definition "Describes an effect that a chemical has on a gene or gene product (e.g. an impact of on its abundance, activity,localization, processing, expression, etc.)" ;
    skos:inScheme biolink: .

biolink:ChemicalEntityAssessesNamedThingAssociation a owl:Class ;
    rdfs:label "chemical entity assesses named thing association" ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:minCardinality 1 ;
            owl:onProperty biolink:predicate ],
        [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:object ],
        [ a owl:Restriction ;
            owl:allValuesFrom biolink:ChemicalEntity ;
            owl:onProperty biolink:subject ],
        [ a owl:Restriction ;
            owl:minCardinality 1 ;
            owl:onProperty biolink:subject ],
        [ a owl:Restriction ;
            owl:allValuesFrom xsd:string ;
            owl:onProperty biolink:predicate ],
        [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:subject ],
        [ a owl:Restriction ;
            owl:minCardinality 1 ;
            owl:onProperty biolink:object ],
        [ a owl:Restriction ;
            owl:allValuesFrom biolink:NamedThing ;
            owl:onProperty biolink:object ],
        [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:predicate ],
        biolink:Association ;
    skos:inScheme biolink: .

biolink:ChemicalEntityOrGeneOrGeneProductRegulatesGeneAssociation a owl:Class ;
    rdfs:label "chemical entity or gene or gene product regulates gene association" ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:allValuesFrom biolink:GeneOrGeneProduct ;
            owl:onProperty biolink:object ],
        [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:object_direction_qualifier ],
        [ a owl:Restriction ;
            owl:allValuesFrom xsd:string ;
            owl:onProperty biolink:predicate ],
        [ a owl:Restriction ;
            owl:minCardinality 0 ;
            owl:onProperty biolink:object_direction_qualifier ],
        [ a owl:Restriction ;
            owl:minCardinality 1 ;
            owl:onProperty biolink:object ],
        [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:predicate ],
        [ a owl:Restriction ;
            owl:minCardinality 1 ;
            owl:onProperty biolink:predicate ],
        [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:subject ],
        [ a owl:Restriction ;
            owl:allValuesFrom biolink:ChemicalEntityOrGeneOrGeneProduct ;
            owl:onProperty biolink:subject ],
        [ a owl:Restriction ;
            owl:allValuesFrom biolink:DirectionQualifierEnum ;
            owl:onProperty biolink:object_direction_qualifier ],
        [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:object ],
        [ a owl:Restriction ;
            owl:minCardinality 1 ;
            owl:onProperty biolink:subject ],
        biolink:Association ;
    skos:definition "A regulatory relationship between two genes" ;
    skos:inScheme biolink: .

biolink:ChemicalEntityToAnatomicalEntityAssociation a owl:Class ;
    rdfs:label "chemical entity to anatomical entity association" ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:minCardinality 1 ;
            owl:onProperty biolink:subject ],
        [ a owl:Restriction ;
            owl:minCardinality 1 ;
            owl:onProperty biolink:object ],
        [ a owl:Restriction ;
            owl:allValuesFrom biolink:ChemicalEntity ;
            owl:onProperty biolink:subject ],
        [ a owl:Restriction ;
            owl:allValuesFrom biolink:AnatomicalEntity ;
            owl:onProperty biolink:object ],
        [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:object ],
        [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:subject ],
        biolink:Association ;
    skos:definition "An association between a chemical entity (other than 'gene or gene product or gene family', for example, a metabolite) and an anatomical entity, such as a tissue or subcellular location." ;
    skos:inScheme biolink: .

biolink:ChemicalEntityToBiologicalProcessAssociation a owl:Class ;
    rdfs:label "chemical entity to biological process association" ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:minCardinality 0 ;
            owl:onProperty biolink:qualified_predicate ],
        [ a owl:Restriction ;
            owl:allValuesFrom xsd:anyURI ;
            owl:onProperty biolink:qualified_predicate ],
        [ a owl:Restriction ;
            owl:allValuesFrom biolink:ChemicalEntity ;
            owl:onProperty biolink:subject ],
        [ a owl:Restriction ;
            owl:allValuesFrom biolink:BiologicalProcess ;
            owl:onProperty biolink:object ],
        [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:qualified_predicate ],
        [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:object_direction_qualifier ],
        [ a owl:Restriction ;
            owl:minCardinality 0 ;
            owl:onProperty biolink:object_direction_qualifier ],
        [ a owl:Restriction ;
            owl:allValuesFrom xsd:string ;
            owl:onProperty biolink:anatomical_context_qualifier ],
        [ a owl:Restriction ;
            owl:minCardinality 1 ;
            owl:onProperty biolink:object ],
        [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:object ],
        [ a owl:Restriction ;
            owl:allValuesFrom biolink:DirectionQualifierEnum ;
            owl:onProperty biolink:object_direction_qualifier ],
        [ a owl:Restriction ;
            owl:minCardinality 0 ;
            owl:onProperty biolink:anatomical_context_qualifier ],
        [ a owl:Restriction ;
            owl:minCardinality 1 ;
            owl:onProperty biolink:predicate ],
        [ a owl:Restriction ;
            owl:allValuesFrom xsd:string ;
            owl:onProperty biolink:predicate ],
        [ a owl:Restriction ;
            owl:minCardinality 0 ;
            owl:onProperty biolink:species_context_qualifier ],
        [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:subject ],
        [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:predicate ],
        [ a owl:Restriction ;
            owl:allValuesFrom biolink:OrganismTaxon ;
            owl:onProperty biolink:species_context_qualifier ],
        [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:species_context_qualifier ],
        [ a owl:Restriction ;
            owl:minCardinality 1 ;
            owl:onProperty biolink:subject ],
        biolink:Association ;
    skos:definition "An association between a chemical entity and a biological process, where the chemical entity has some effect on the biological process." ;
    skos:inScheme biolink: .

biolink:ChemicalEntityToChemicalDerivationAssociation a owl:Class ;
    rdfs:label "chemical entity to chemical derivation association" ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:allValuesFrom biolink:ChemicalEntity ;
            owl:onProperty biolink:object ],
        [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:object ],
        [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:subject ],
        [ a owl:Restriction ;
            owl:minCardinality 0 ;
            owl:onProperty biolink:catalyst_qualifier ],
        [ a owl:Restriction ;
            owl:minCardinality 1 ;
            owl:onProperty biolink:predicate ],
        [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:predicate ],
        [ a owl:Restriction ;
            owl:allValuesFrom xsd:string ;
            owl:onProperty biolink:predicate ],
        [ a owl:Restriction ;
            owl:allValuesFrom biolink:ChemicalEntity ;
            owl:onProperty biolink:subject ],
        [ a owl:Restriction ;
            owl:allValuesFrom biolink:MacromolecularMachineMixin ;
            owl:onProperty biolink:catalyst_qualifier ],
        [ a owl:Restriction ;
            owl:minCardinality 1 ;
            owl:onProperty biolink:subject ],
        [ a owl:Restriction ;
            owl:minCardinality 1 ;
            owl:onProperty biolink:object ],
        biolink:ChemicalEntityToChemicalEntityAssociation ;
    skos:definition "A causal relationship between two chemical entities, where the subject represents the upstream entity and the object represents the downstream. For any such association there is an implicit reaction: IF R has-input C1 AND R has-output C2 AND R enabled-by P AND R type Reaction THEN C1 derives-into C2 catalyst qualifier P" ;
    skos:inScheme biolink: .

biolink:ChemicalEntityToDiseaseOrPhenotypicFeatureAssociation a owl:Class ;
    rdfs:label "chemical entity to disease or phenotypic feature association" ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:minCardinality 1 ;
            owl:onProperty biolink:object ],
        [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:object ],
        [ a owl:Restriction ;
            owl:onProperty linkml:mixins ;
            owl:someValuesFrom biolink:EntityToDiseaseOrPhenotypicFeatureAssociationMixin ],
        [ a owl:Restriction ;
            owl:allValuesFrom biolink:DiseaseOrPhenotypicFeature ;
            owl:onProperty biolink:object ],
        biolink:Association ;
    skos:definition "An interaction between a chemical entity and a phenotype or disease, where the presence of the chemical gives rise to or exacerbates the phenotype." ;
    skos:inScheme biolink: ;
    skos:narrowMatch SIO:000993 .

biolink:ChemicalEntityToPathwayAssociation a owl:Class ;
    rdfs:label "chemical entity to pathway association" ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:allValuesFrom biolink:ChemicalEntity ;
            owl:onProperty biolink:subject ],
        [ a owl:Restriction ;
            owl:allValuesFrom biolink:Pathway ;
            owl:onProperty biolink:object ],
        [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:subject ],
        [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:object ],
        [ a owl:Restriction ;
            owl:minCardinality 1 ;
            owl:onProperty biolink:subject ],
        [ a owl:Restriction ;
            owl:minCardinality 1 ;
            owl:onProperty biolink:object ],
        biolink:Association ;
    skos:definition "An interaction between a chemical entity and a biological process or pathway." ;
    skos:exactMatch SIO:001250 ;
    skos:inScheme biolink: .

biolink:ChemicalGeneInteractionAssociation a owl:Class ;
    rdfs:label "chemical gene interaction association" ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:object_aspect_qualifier ],
        [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:dgidb_interaction_score ],
        [ a owl:Restriction ;
            owl:allValuesFrom xsd:integer ;
            owl:onProperty biolink:dgidb_evidence_score ],
        [ a owl:Restriction ;
            owl:minCardinality 0 ;
            owl:onProperty biolink:subject_part_qualifier ],
        [ a owl:Restriction ;
            owl:minCardinality 0 ;
            owl:onProperty biolink:species_context_qualifier ],
        [ a owl:Restriction ;
            owl:minCardinality 0 ;
            owl:onProperty biolink:anatomical_context_qualifier ],
        [ a owl:Restriction ;
            owl:allValuesFrom biolink:CausalMechanismQualifierEnum ;
            owl:onProperty biolink:causal_mechanism_qualifier ],
        [ a owl:Restriction ;
            owl:allValuesFrom biolink:GeneOrGeneProductOrChemicalPartQualifierEnum ;
            owl:onProperty biolink:subject_part_qualifier ],
        [ a owl:Restriction ;
            owl:allValuesFrom biolink:ChemicalOrGeneOrGeneProductFormOrVariantEnum ;
            owl:onProperty biolink:subject_form_or_variant_qualifier ],
        [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:object_context_qualifier ],
        [ a owl:Restriction ;
            owl:minCardinality 0 ;
            owl:onProperty biolink:subject_form_or_variant_qualifier ],
        [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:object ],
        [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:subject ],
        [ a owl:Restriction ;
            owl:minCardinality 0 ;
            owl:onProperty biolink:dgidb_interaction_score ],
        [ a owl:Restriction ;
            owl:minCardinality 1 ;
            owl:onProperty biolink:subject ],
        [ a owl:Restriction ;
            owl:minCardinality 0 ;
            owl:onProperty biolink:object_context_qualifier ],
        [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:object_form_or_variant_qualifier ],
        [ a owl:Restriction ;
            owl:allValuesFrom biolink:AnatomicalEntity ;
            owl:onProperty biolink:anatomical_context_qualifier ],
        [ a owl:Restriction ;
            owl:minCardinality 0 ;
            owl:onProperty biolink:object_aspect_qualifier ],
        [ a owl:Restriction ;
            owl:minCardinality 0 ;
            owl:onProperty biolink:object_part_qualifier ],
        [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:dgidb_evidence_score ],
        [ a owl:Restriction ;
            owl:allValuesFrom biolink:AnatomicalEntity ;
            owl:onProperty biolink:object_context_qualifier ],
        [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:qualified_predicate ],
        [ a owl:Restriction ;
            owl:allValuesFrom biolink:ChemicalEntity ;
            owl:onProperty biolink:subject ],
        [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:subject_form_or_variant_qualifier ],
        [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:subject_part_qualifier ],
        [ a owl:Restriction ;
            owl:allValuesFrom xsd:anyURI ;
            owl:onProperty biolink:qualified_predicate ],
        [ a owl:Restriction ;
            owl:allValuesFrom biolink:OrganismTaxon ;
            owl:onProperty biolink:species_context_qualifier ],
        [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:species_context_qualifier ],
        [ a owl:Restriction ;
            owl:allValuesFrom biolink:ChemicalOrGeneOrGeneProductFormOrVariantEnum ;
            owl:onProperty biolink:object_form_or_variant_qualifier ],
        [ a owl:Restriction ;
            owl:minCardinality 1 ;
            owl:onProperty biolink:predicate ],
        [ a owl:Restriction ;
            owl:minCardinality 1 ;
            owl:onProperty biolink:object ],
        [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:subject_context_qualifier ],
        [ a owl:Restriction ;
            owl:minCardinality 0 ;
            owl:onProperty biolink:object_form_or_variant_qualifier ],
        [ a owl:Restriction ;
            owl:allValuesFrom biolink:GeneOrGeneProduct ;
            owl:onProperty biolink:object ],
        [ a owl:Restriction ;
            owl:allValuesFrom xsd:string ;
            owl:onProperty biolink:predicate ],
        [ a owl:Restriction ;
            owl:allValuesFrom biolink:GeneOrGeneProductOrChemicalPartQualifierEnum ;
            owl:onProperty biolink:object_part_qualifier ],
        [ a owl:Restriction ;
            owl:minCardinality 0 ;
            owl:onProperty biolink:causal_mechanism_qualifier ],
        [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:predicate ],
        [ a owl:Restriction ;
            owl:allValuesFrom biolink:ChemicalEntityDerivativeEnum ;
            owl:onProperty biolink:subject_derivative_qualifier ],
        [ a owl:Restriction ;
            owl:allValuesFrom xsd:float ;
            owl:onProperty biolink:dgidb_interaction_score ],
        [ a owl:Restriction ;
            owl:minCardinality 0 ;
            owl:onProperty biolink:object_direction_qualifier ],
        [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:object_part_qualifier ],
        [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:causal_mechanism_qualifier ],
        [ a owl:Restriction ;
            owl:minCardinality 0 ;
            owl:onProperty biolink:dgidb_evidence_score ],
        [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:subject_derivative_qualifier ],
        [ a owl:Restriction ;
            owl:minCardinality 0 ;
            owl:onProperty biolink:qualified_predicate ],
        [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:object_direction_qualifier ],
        [ a owl:Restriction ;
            owl:minCardinality 0 ;
            owl:onProperty biolink:subject_derivative_qualifier ],
        [ a owl:Restriction ;
            owl:allValuesFrom biolink:AnatomicalEntity ;
            owl:onProperty biolink:subject_context_qualifier ],
        [ a owl:Restriction ;
            owl:allValuesFrom biolink:GeneOrGeneProductOrChemicalEntityAspectEnum ;
            owl:onProperty biolink:object_aspect_qualifier ],
        [ a owl:Restriction ;
            owl:allValuesFrom biolink:DirectionQualifierEnum ;
            owl:onProperty biolink:object_direction_qualifier ],
        [ a owl:Restriction ;
            owl:minCardinality 0 ;
            owl:onProperty biolink:subject_context_qualifier ],
        biolink:Association ;
    skos:broadMatch SIO:001257 ;
    skos:definition "describes an interaction between a chemical entity and a gene or gene product. Any biological or chemical effect resulting from such an interaction are out of scope, and covered by the ChemicalAffectsGeneAssociation type (e.g. impact of a chemical on the abundance, activity, structure, etc, of either participant in the interaction)" ;
    skos:inScheme biolink: .

biolink:ChemicalGeneSensitivityAssociation a owl:Class ;
    rdfs:label "chemical gene sensitivity association" ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:object_aspect_qualifier ],
        [ a owl:Restriction ;
            owl:minCardinality 0 ;
            owl:onProperty biolink:subject_part_qualifier ],
        [ a owl:Restriction ;
            owl:allValuesFrom xsd:integer ;
            owl:onProperty biolink:evidence_count ],
        [ a owl:Restriction ;
            owl:minCardinality 0 ;
            owl:onProperty biolink:qualified_predicate ],
        [ a owl:Restriction ;
            owl:allValuesFrom xsd:anyURI ;
            owl:onProperty biolink:supporting_documents ],
        [ a owl:Restriction ;
            owl:allValuesFrom biolink:ChemicalOrGeneOrGeneProductFormOrVariantEnum ;
            owl:onProperty biolink:subject_form_or_variant_qualifier ],
        [ a owl:Restriction ;
            owl:minCardinality 0 ;
            owl:onProperty biolink:species_context_qualifier ],
        [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:subject_form_or_variant_qualifier ],
        [ a owl:Restriction ;
            owl:minCardinality 0 ;
            owl:onProperty biolink:object_aspect_qualifier ],
        [ a owl:Restriction ;
            owl:minCardinality 0 ;
            owl:onProperty biolink:subject_direction_qualifier ],
        [ a owl:Restriction ;
            owl:minCardinality 0 ;
            owl:onProperty biolink:subject_form_or_variant_qualifier ],
        [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:species_context_qualifier ],
        [ a owl:Restriction ;
            owl:minCardinality 0 ;
            owl:onProperty biolink:object_direction_qualifier ],
        [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:object_direction_qualifier ],
        [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:qualified_predicate ],
        [ a owl:Restriction ;
            owl:allValuesFrom biolink:OrganismTaxon ;
            owl:onProperty biolink:species_context_qualifier ],
        [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:object_derivative_qualifier ],
        [ a owl:Restriction ;
            owl:allValuesFrom xsd:string ;
            owl:onProperty biolink:predicate ],
        [ a owl:Restriction ;
            owl:minCardinality 0 ;
            owl:onProperty biolink:subject_aspect_qualifier ],
        [ a owl:Restriction ;
            owl:allValuesFrom biolink:GeneOrGeneProductOrChemicalPartQualifierEnum ;
            owl:onProperty biolink:object_part_qualifier ],
        [ a owl:Restriction ;
            owl:allValuesFrom biolink:DirectionQualifierEnum ;
            owl:onProperty biolink:subject_direction_qualifier ],
        [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:object_part_qualifier ],
        [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:object ],
        [ a owl:Restriction ;
            owl:allValuesFrom biolink:ChemicalOrGeneOrGeneProductFormOrVariantEnum ;
            owl:onProperty biolink:object_form_or_variant_qualifier ],
        [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:object_form_or_variant_qualifier ],
        [ a owl:Restriction ;
            owl:allValuesFrom biolink:AnatomicalEntity ;
            owl:onProperty biolink:anatomical_context_qualifier ],
        [ a owl:Restriction ;
            owl:minCardinality 0 ;
            owl:onProperty biolink:object_form_or_variant_qualifier ],
        [ a owl:Restriction ;
            owl:minCardinality 1 ;
            owl:onProperty biolink:predicate ],
        [ a owl:Restriction ;
            owl:allValuesFrom biolink:DirectionQualifierEnum ;
            owl:onProperty biolink:object_direction_qualifier ],
        [ a owl:Restriction ;
            owl:allValuesFrom biolink:GeneOrGeneProductOrChemicalEntityAspectEnum ;
            owl:onProperty biolink:subject_aspect_qualifier ],
        [ a owl:Restriction ;
            owl:allValuesFrom xsd:anyURI ;
            owl:onProperty biolink:qualified_predicate ],
        [ a owl:Restriction ;
            owl:minCardinality 0 ;
            owl:onProperty biolink:object_part_qualifier ],
        [ a owl:Restriction ;
            owl:allValuesFrom biolink:ChemicalEntityDerivativeEnum ;
            owl:onProperty biolink:object_derivative_qualifier ],
        [ a owl:Restriction ;
            owl:minCardinality 1 ;
            owl:onProperty biolink:subject ],
        [ a owl:Restriction ;
            owl:allValuesFrom biolink:GeneOrGeneProduct ;
            owl:onProperty biolink:object ],
        [ a owl:Restriction ;
            owl:minCardinality 0 ;
            owl:onProperty biolink:evidence_count ],
        [ a owl:Restriction ;
            owl:allValuesFrom biolink:ChemicalEntity ;
            owl:onProperty biolink:subject ],
        [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:subject ],
        [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:subject_aspect_qualifier ],
        [ a owl:Restriction ;
            owl:minCardinality 0 ;
            owl:onProperty biolink:object_derivative_qualifier ],
        [ a owl:Restriction ;
            owl:allValuesFrom biolink:GeneOrGeneProductOrChemicalEntityAspectEnum ;
            owl:onProperty biolink:object_aspect_qualifier ],
        [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:subject_derivative_qualifier ],
        [ a owl:Restriction ;
            owl:minCardinality 0 ;
            owl:onProperty biolink:subject_derivative_qualifier ],
        [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:subject_direction_qualifier ],
        [ a owl:Restriction ;
            owl:minCardinality 1 ;
            owl:onProperty biolink:object ],
        [ a owl:Restriction ;
            owl:minCardinality 0 ;
            owl:onProperty biolink:supporting_documents ],
        [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:subject_part_qualifier ],
        [ a owl:Restriction ;
            owl:allValuesFrom biolink:ChemicalEntityDerivativeEnum ;
            owl:onProperty biolink:subject_derivative_qualifier ],
        [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:predicate ],
        [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:evidence_count ],
        [ a owl:Restriction ;
            owl:allValuesFrom biolink:GeneOrGeneProductOrChemicalPartQualifierEnum ;
            owl:onProperty biolink:subject_part_qualifier ],
        [ a owl:Restriction ;
            owl:minCardinality 0 ;
            owl:onProperty biolink:anatomical_context_qualifier ],
        biolink:Association ;
    skos:broadMatch SIO:001257 ;
    skos:definition "Describes a relationship in which a chemical entity affects the sensitivity or susceptibility of a biological system to a gene or gene product (e.g. a chemical that increases or decreases the response to a gene or gene product). This covers 'response to substance' style interactions from sources such as CTD that map to the 'affects sensitivity to' predicate hierarchy, as opposed to the abundance/activity/processing effects covered by ChemicalAffectsGeneAssociation." ;
    skos:inScheme biolink: .

biolink:ChemicalOrDrugOrTreatmentAdverseEventAssociation a owl:Class ;
    rdfs:label "chemical or drug or treatment adverse event association" ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:predicate ],
        [ a owl:Restriction ;
            owl:allValuesFrom xsd:string ;
            owl:onProperty biolink:predicate ],
        [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:FDA_adverse_event_level ],
        [ a owl:Restriction ;
            owl:allValuesFrom biolink:FDAIDAAdverseEventEnum ;
            owl:onProperty biolink:FDA_adverse_event_level ],
        [ a owl:Restriction ;
            owl:onProperty linkml:mixins ;
            owl:someValuesFrom biolink:EntityToDiseaseOrPhenotypicFeatureAssociationMixin ],
        [ a owl:Restriction ;
            owl:minCardinality 1 ;
            owl:onProperty biolink:predicate ],
        [ a owl:Restriction ;
            owl:minCardinality 0 ;
            owl:onProperty biolink:FDA_adverse_event_level ],
        biolink:Association ;
    skos:definition "This association defines a relationship between a chemical or treatment (or procedure) and a disease or phenotypic feature where the disease or phenotypic feature is an untoward medical occurrence that happens during treatment, whether or not considered related to the treatment." ;
    skos:inScheme biolink: .

biolink:ChemicalOrDrugOrTreatmentSideEffectAssociation a owl:Class ;
    rdfs:label "chemical or drug or treatment side effect association" ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:predicate ],
        [ a owl:Restriction ;
            owl:onProperty linkml:mixins ;
            owl:someValuesFrom biolink:EntityToDiseaseOrPhenotypicFeatureAssociationMixin ],
        [ a owl:Restriction ;
            owl:allValuesFrom xsd:string ;
            owl:onProperty biolink:predicate ],
        [ a owl:Restriction ;
            owl:minCardinality 1 ;
            owl:onProperty biolink:predicate ],
        biolink:Association ;
    skos:definition "This association defines a relationship between a chemical or treatment (or procedure) and a disease or phenotypic feature where the disease or phenotypic feature is an unintended, but predictable, secondary effect of the treatment." ;
    skos:inScheme biolink: .

biolink:ChemicalOrDrugOrTreatmentToDiseaseOrPhenotypicFeatureAssociation a owl:Class ;
    rdfs:label "chemical or drug or treatment to disease or phenotypic feature association" ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:onProperty linkml:mixins ;
            owl:someValuesFrom biolink:ClinicalTrialAndRegulatoryApprovalContextMixin ],
        [ a owl:Restriction ;
            owl:allValuesFrom biolink:TreatmentOutcomeEnum ;
            owl:onProperty biolink:treatment_outcome ],
        [ a owl:Restriction ;
            owl:minCardinality 0 ;
            owl:onProperty biolink:treatment_outcome ],
        [ a owl:Restriction ;
            owl:onProperty linkml:mixins ;
            owl:someValuesFrom biolink:EntityToDiseaseOrPhenotypicFeatureAssociationMixin ],
        [ a owl:Restriction ;
            owl:minCardinality 1 ;
            owl:onProperty biolink:predicate ],
        [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:predicate ],
        [ a owl:Restriction ;
            owl:allValuesFrom xsd:string ;
            owl:onProperty biolink:predicate ],
        biolink:Association ;
    skos:definition "This association defines a relationship between a chemical or treatment (or procedure) and a disease or phenotypic feature where the chemical or treatment is used to treat, or is being studied to treat, the disease or phenotypic feature." ;
    skos:inScheme biolink: .

<https://w3id.org/biolink/vocab/ChemicalOrGeneOrGeneProductFormOrVariantEnum#analog_form> a owl:Class ;
    rdfs:label "analog_form" ;
    rdfs:subClassOf biolink:ChemicalOrGeneOrGeneProductFormOrVariantEnum,
        <https://w3id.org/biolink/vocab/ChemicalOrGeneOrGeneProductFormOrVariantEnum#modified_form> .

<https://w3id.org/biolink/vocab/ChemicalOrGeneOrGeneProductFormOrVariantEnum#dominant_negative_variant_form> a owl:Class ;
    rdfs:label "dominant_negative_variant_form" ;
    rdfs:subClassOf biolink:ChemicalOrGeneOrGeneProductFormOrVariantEnum,
        <https://w3id.org/biolink/vocab/ChemicalOrGeneOrGeneProductFormOrVariantEnum#non_loss_of_function_variant_form> .

<https://w3id.org/biolink/vocab/ChemicalOrGeneOrGeneProductFormOrVariantEnum#gain_of_function_variant_form> a owl:Class ;
    rdfs:label "gain_of_function_variant_form" ;
    rdfs:subClassOf biolink:ChemicalOrGeneOrGeneProductFormOrVariantEnum,
        <https://w3id.org/biolink/vocab/ChemicalOrGeneOrGeneProductFormOrVariantEnum#non_loss_of_function_variant_form> .

<https://w3id.org/biolink/vocab/ChemicalOrGeneOrGeneProductFormOrVariantEnum#loss_of_function_variant_form> a owl:Class ;
    rdfs:label "loss_of_function_variant_form" ;
    rdfs:subClassOf biolink:ChemicalOrGeneOrGeneProductFormOrVariantEnum,
        <https://w3id.org/biolink/vocab/ChemicalOrGeneOrGeneProductFormOrVariantEnum#genetic_variant_form> .

<https://w3id.org/biolink/vocab/ChemicalOrGeneOrGeneProductFormOrVariantEnum#mutant_form> a owl:Class ;
    rdfs:label "mutant_form" ;
    rdfs:subClassOf biolink:ChemicalOrGeneOrGeneProductFormOrVariantEnum,
        <https://w3id.org/biolink/vocab/ChemicalOrGeneOrGeneProductFormOrVariantEnum#genetic_variant_form> .

<https://w3id.org/biolink/vocab/ChemicalOrGeneOrGeneProductFormOrVariantEnum#snp_form> a owl:Class ;
    rdfs:label "snp_form" ;
    rdfs:subClassOf biolink:ChemicalOrGeneOrGeneProductFormOrVariantEnum,
        <https://w3id.org/biolink/vocab/ChemicalOrGeneOrGeneProductFormOrVariantEnum#polymorphic_form> .

<https://w3id.org/biolink/vocab/ClinicalApprovalStatusEnum#fda_approved_for_condition> a owl:Class ;
    rdfs:label "fda_approved_for_condition" ;
    rdfs:subClassOf biolink:ClinicalApprovalStatusEnum,
        <https://w3id.org/biolink/vocab/ClinicalApprovalStatusEnum#approved_for_condition> .

<https://w3id.org/biolink/vocab/ClinicalApprovalStatusEnum#not_provided> a owl:Class ;
    rdfs:label "not_provided" ;
    rdfs:subClassOf biolink:ClinicalApprovalStatusEnum,
        linkml:PermissibleValue .

<https://w3id.org/biolink/vocab/ClinicalApprovalStatusEnum#off_label_use> a owl:Class ;
    rdfs:label "off_label_use" ;
    rdfs:subClassOf biolink:ClinicalApprovalStatusEnum,
        <https://w3id.org/biolink/vocab/ClinicalApprovalStatusEnum#not_approved_for_condition> .

<https://w3id.org/biolink/vocab/ClinicalApprovalStatusEnum#post_approval_withdrawal> a owl:Class ;
    rdfs:label "post_approval_withdrawal" ;
    rdfs:subClassOf biolink:ClinicalApprovalStatusEnum,
        <https://w3id.org/biolink/vocab/ClinicalApprovalStatusEnum#not_approved_for_condition> .

biolink:ClinicalFinding a owl:Class ;
    rdfs:label "clinical finding" ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:allValuesFrom biolink:ClinicalAttribute ;
            owl:onProperty biolink:has_attribute ],
        [ a owl:Restriction ;
            owl:minCardinality 0 ;
            owl:onProperty biolink:has_attribute ],
        biolink:PhenotypicFeature ;
    skos:definition "this category is currently considered broad enough to tag clinical lab measurements and other biological attributes taken as 'clinical traits' with some statistical score, for example, a p value in genetic associations." ;
    skos:inScheme biolink: .

biolink:ClinicalMeasurement a owl:Class ;
    rdfs:label "clinical measurement" ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:allValuesFrom owl:Thing ;
            owl:onProperty biolink:has_attribute_type ],
        [ a owl:Restriction ;
            owl:minCardinality 1 ;
            owl:onProperty biolink:has_attribute_type ],
        [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:has_attribute_type ],
        biolink:ClinicalAttribute ;
    skos:definition "A clinical measurement is a special kind of attribute which results from a laboratory observation from a subject individual or sample. Measurements can be connected to their subject by the 'has attribute' slot." ;
    skos:exactMatch EFO:0001444 ;
    skos:inScheme biolink: .

<https://w3id.org/biolink/vocab/ClinicalTrialAgeStageEnum#adult> a owl:Class ;
    rdfs:label "adult" ;
    rdfs:subClassOf biolink:ClinicalTrialAgeStageEnum,
        linkml:PermissibleValue .

<https://w3id.org/biolink/vocab/ClinicalTrialAgeStageEnum#child> a owl:Class ;
    rdfs:label "child" ;
    rdfs:subClassOf biolink:ClinicalTrialAgeStageEnum,
        linkml:PermissibleValue .

<https://w3id.org/biolink/vocab/ClinicalTrialAgeStageEnum#older_adult> a owl:Class ;
    rdfs:label "older_adult" ;
    rdfs:subClassOf biolink:ClinicalTrialAgeStageEnum,
        linkml:PermissibleValue .

<https://w3id.org/biolink/vocab/ClinicalTrialStatusEnum#ACTIVE_NOT_RECRUITING> a owl:Class ;
    rdfs:label "ACTIVE_NOT_RECRUITING" ;
    rdfs:subClassOf biolink:ClinicalTrialStatusEnum,
        linkml:PermissibleValue ;
    skos:definition "The study is ongoing but not currently recruiting participants." .

<https://w3id.org/biolink/vocab/ClinicalTrialStatusEnum#APPROVED_FOR_MARKETING> a owl:Class ;
    rdfs:label "APPROVED_FOR_MARKETING" ;
    rdfs:subClassOf biolink:ClinicalTrialStatusEnum,
        linkml:PermissibleValue ;
    skos:definition "The intervention has received regulatory approval for marketing." .

<https://w3id.org/biolink/vocab/ClinicalTrialStatusEnum#AVAILABLE> a owl:Class ;
    rdfs:label "AVAILABLE" ;
    rdfs:subClassOf biolink:ClinicalTrialStatusEnum,
        linkml:PermissibleValue ;
    skos:definition "The intervention or data is available for use or distribution." .

<https://w3id.org/biolink/vocab/ClinicalTrialStatusEnum#COMPLETED> a owl:Class ;
    rdfs:label "COMPLETED" ;
    rdfs:subClassOf biolink:ClinicalTrialStatusEnum,
        linkml:PermissibleValue ;
    skos:definition "The study has ended normally and participants are no longer being examined or treated." .

<https://w3id.org/biolink/vocab/ClinicalTrialStatusEnum#ENROLLING_BY_INVITATION> a owl:Class ;
    rdfs:label "ENROLLING_BY_INVITATION" ;
    rdfs:subClassOf biolink:ClinicalTrialStatusEnum,
        linkml:PermissibleValue ;
    skos:definition "Participants are being enrolled by invitation only." .

<https://w3id.org/biolink/vocab/ClinicalTrialStatusEnum#NOT_YET_RECRUITING> a owl:Class ;
    rdfs:label "NOT_YET_RECRUITING" ;
    rdfs:subClassOf biolink:ClinicalTrialStatusEnum,
        linkml:PermissibleValue ;
    skos:definition "The study has not yet started recruiting participants." .

<https://w3id.org/biolink/vocab/ClinicalTrialStatusEnum#NO_LONGER_AVAILABLE> a owl:Class ;
    rdfs:label "NO_LONGER_AVAILABLE" ;
    rdfs:subClassOf biolink:ClinicalTrialStatusEnum,
        linkml:PermissibleValue ;
    skos:definition "The intervention or data is no longer available." .

<https://w3id.org/biolink/vocab/ClinicalTrialStatusEnum#RECRUITING> a owl:Class ;
    rdfs:label "RECRUITING" ;
    rdfs:subClassOf biolink:ClinicalTrialStatusEnum,
        linkml:PermissibleValue ;
    skos:definition "The study is currently recruiting participants." .

<https://w3id.org/biolink/vocab/ClinicalTrialStatusEnum#SUSPENDED> a owl:Class ;
    rdfs:label "SUSPENDED" ;
    rdfs:subClassOf biolink:ClinicalTrialStatusEnum,
        linkml:PermissibleValue ;
    skos:definition "The study has been temporarily halted but may resume." .

<https://w3id.org/biolink/vocab/ClinicalTrialStatusEnum#TEMPORARILY_NOT_AVAILABLE> a owl:Class ;
    rdfs:label "TEMPORARILY_NOT_AVAILABLE" ;
    rdfs:subClassOf biolink:ClinicalTrialStatusEnum,
        linkml:PermissibleValue ;
    skos:definition "The intervention or data is not currently available but may become available later." .

<https://w3id.org/biolink/vocab/ClinicalTrialStatusEnum#TERMINATED> a owl:Class ;
    rdfs:label "TERMINATED" ;
    rdfs:subClassOf biolink:ClinicalTrialStatusEnum,
        linkml:PermissibleValue ;
    skos:definition "The study has stopped prematurely and will not start again." .

<https://w3id.org/biolink/vocab/ClinicalTrialStatusEnum#UNKNOWN> a owl:Class ;
    rdfs:label "UNKNOWN" ;
    rdfs:subClassOf biolink:ClinicalTrialStatusEnum,
        linkml:PermissibleValue ;
    skos:definition "The recruitment or availability status is unknown." .

<https://w3id.org/biolink/vocab/ClinicalTrialStatusEnum#WITHDRAWN> a owl:Class ;
    rdfs:label "WITHDRAWN" ;
    rdfs:subClassOf biolink:ClinicalTrialStatusEnum,
        linkml:PermissibleValue ;
    skos:definition "The study was halted before enrolling its first participant." .

biolink:Cohort a owl:Class ;
    rdfs:label "cohort" ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:onProperty linkml:mixins ;
            owl:someValuesFrom biolink:SubjectOfInvestigation ],
        biolink:StudyPopulation ;
    skos:definition "A group of people banded together or treated as a group who share common characteristics. A cohort 'study' is a particular form of longitudinal study that samples a cohort, performing a cross-section at intervals through time." ;
    skos:exactMatch WIKIDATA:Q1303415 ;
    skos:inScheme biolink: ;
    skos:narrowMatch STY:T097,
        STY:T099,
        STY:T100,
        STY:T101 .

biolink:ComplexChemicalExposure a owl:Class ;
    rdfs:label "complex chemical exposure" ;
    rdfs:subClassOf biolink:ExposureEvent ;
    skos:definition "A complex chemical exposure is an intake of a chemical mixture, other than a drug." ;
    skos:inScheme biolink: .

biolink:ComplexMolecularMixture a owl:Class ;
    rdfs:label "complex molecular mixture" ;
    rdfs:subClassOf biolink:ChemicalMixture ;
    skos:definition "A complex molecular mixture is a chemical mixture composed of two or more molecular entities with unknown concentration and stoichiometry." ;
    skos:inScheme biolink: .

biolink:ContributorAssociation a owl:Class ;
    rdfs:label "contributor association" ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:minCardinality 0 ;
            owl:onProperty biolink:qualifiers ],
        [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:predicate ],
        [ a owl:Restriction ;
            owl:allValuesFrom biolink:InformationContentEntity ;
            owl:onProperty biolink:subject ],
        [ a owl:Restriction ;
            owl:minCardinality 1 ;
            owl:onProperty biolink:subject ],
        [ a owl:Restriction ;
            owl:minCardinality 1 ;
            owl:onProperty biolink:object ],
        [ a owl:Restriction ;
            owl:allValuesFrom owl:Thing ;
            owl:onProperty biolink:qualifiers ],
        [ a owl:Restriction ;
            owl:allValuesFrom biolink:Agent ;
            owl:onProperty biolink:object ],
        [ a owl:Restriction ;
            owl:minCardinality 1 ;
            owl:onProperty biolink:predicate ],
        [ a owl:Restriction ;
            owl:allValuesFrom xsd:string ;
            owl:onProperty biolink:predicate ],
        [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:object ],
        [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:subject ],
        biolink:Association ;
    skos:definition "Any association between an entity (such as a publication) and various agents that contribute to its realisation" ;
    skos:inScheme biolink: .

biolink:CorrelatedGeneToDiseaseAssociation a owl:Class ;
    rdfs:label "correlated gene to disease association" ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:z_score ],
        [ a owl:Restriction ;
            owl:onProperty linkml:mixins ;
            owl:someValuesFrom biolink:GeneToEntityAssociationMixin ],
        [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:subject_form_or_variant_qualifier ],
        [ a owl:Restriction ;
            owl:allValuesFrom xsd:float ;
            owl:onProperty biolink:diseases_confidence_score ],
        [ a owl:Restriction ;
            owl:allValuesFrom xsd:string ;
            owl:onProperty biolink:predicate ],
        [ a owl:Restriction ;
            owl:minCardinality 1 ;
            owl:onProperty biolink:subject ],
        [ a owl:Restriction ;
            owl:onProperty linkml:mixins ;
            owl:someValuesFrom biolink:EntityToDiseaseAssociationMixin ],
        [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:object ],
        [ a owl:Restriction ;
            owl:minCardinality 0 ;
            owl:onProperty biolink:subject_form_or_variant_qualifier ],
        [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:qualified_predicate ],
        [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:subject ],
        [ a owl:Restriction ;
            owl:allValuesFrom biolink:Disease ;
            owl:onProperty biolink:object ],
        [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:allelic_requirement ],
        [ a owl:Restriction ;
            owl:allValuesFrom xsd:string ;
            owl:onProperty biolink:subject_form_or_variant_qualifier ],
        [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:diseases_confidence_score ],
        [ a owl:Restriction ;
            owl:minCardinality 0 ;
            owl:onProperty biolink:diseases_confidence_score ],
        [ a owl:Restriction ;
            owl:allValuesFrom [ a rdfs:Datatype ;
                    owl:intersectionOf ( xsd:string [ a rdfs:Datatype ;
                                owl:onDatatype xsd:string ;
                                owl:withRestrictions ( [ xsd:pattern "^HP:\\d{7}$" ] ) ] ) ] ;
            owl:onProperty biolink:allelic_requirement ],
        [ a owl:Restriction ;
            owl:allValuesFrom biolink:GeneOrGeneProduct ;
            owl:onProperty biolink:subject ],
        [ a owl:Restriction ;
            owl:allValuesFrom biolink:DirectionQualifierEnum ;
            owl:onProperty biolink:object_direction_qualifier ],
        [ a owl:Restriction ;
            owl:minCardinality 0 ;
            owl:onProperty biolink:subject_aspect_qualifier ],
        [ a owl:Restriction ;
            owl:minCardinality 0 ;
            owl:onProperty biolink:qualified_predicate ],
        [ a owl:Restriction ;
            owl:minCardinality 1 ;
            owl:onProperty biolink:predicate ],
        [ a owl:Restriction ;
            owl:allValuesFrom xsd:float ;
            owl:onProperty biolink:z_score ],
        [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:object_direction_qualifier ],
        [ a owl:Restriction ;
            owl:minCardinality 0 ;
            owl:onProperty biolink:object_direction_qualifier ],
        [ a owl:Restriction ;
            owl:allValuesFrom xsd:anyURI ;
            owl:onProperty biolink:qualified_predicate ],
        [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:predicate ],
        [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:subject_aspect_qualifier ],
        [ a owl:Restriction ;
            owl:minCardinality 0 ;
            owl:onProperty biolink:allelic_requirement ],
        [ a owl:Restriction ;
            owl:allValuesFrom biolink:GeneOrGeneProductOrChemicalEntityAspectEnum ;
            owl:onProperty biolink:subject_aspect_qualifier ],
        [ a owl:Restriction ;
            owl:minCardinality 1 ;
            owl:onProperty biolink:object ],
        [ a owl:Restriction ;
            owl:minCardinality 0 ;
            owl:onProperty biolink:z_score ],
        biolink:Association ;
    skos:definition "An association between a gene (or gene product) and a disease for which the gene is statistically correlated with the disease rather than asserted as causal. Such associations typically derive from GWAS, co-occurrence analyses, or other statistical methods, and are annotated with scores such as a z-score or a diseases confidence score." ;
    skos:inScheme biolink: .

<https://w3id.org/biolink/vocab/DirectionQualifierEnum#downregulated> a owl:Class ;
    rdfs:label "downregulated" ;
    rdfs:subClassOf biolink:DirectionQualifierEnum,
        <https://w3id.org/biolink/vocab/DirectionQualifierEnum#decreased> ;
    skos:broadMatch RO:0004033 ;
    skos:closeMatch RO:0002335 ;
    skos:exactMatch RO:0002212,
        RO:0004035 .

<https://w3id.org/biolink/vocab/DirectionQualifierEnum#upregulated> a owl:Class ;
    rdfs:label "upregulated" ;
    rdfs:subClassOf biolink:DirectionQualifierEnum,
        <https://w3id.org/biolink/vocab/DirectionQualifierEnum#increased> ;
    skos:closeMatch RO:0002336 ;
    skos:exactMatch RO:0002213 ;
    skos:narrowMatch RO:0002629,
        RO:0004032,
        RO:0004034 .

biolink:DiseaseAssociatedWithResponseToChemicalEntityAssociation a owl:Class ;
    rdfs:label "disease associated with response to chemical entity association" ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:allValuesFrom biolink:ResponseEnum ;
            owl:onProperty biolink:response_context_qualifier ],
        [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:subject ],
        [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:object ],
        [ a owl:Restriction ;
            owl:allValuesFrom biolink:ChemicalEntity ;
            owl:onProperty biolink:object ],
        [ a owl:Restriction ;
            owl:minCardinality 1 ;
            owl:onProperty biolink:predicate ],
        [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:predicate ],
        [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:response_context_qualifier ],
        [ a owl:Restriction ;
            owl:minCardinality 0 ;
            owl:onProperty biolink:response_context_qualifier ],
        [ a owl:Restriction ;
            owl:minCardinality 0 ;
            owl:onProperty biolink:response_target_context_qualifier ],
        [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:response_target_context_qualifier ],
        [ a owl:Restriction ;
            owl:allValuesFrom biolink:Disease ;
            owl:onProperty biolink:subject ],
        [ a owl:Restriction ;
            owl:allValuesFrom xsd:string ;
            owl:onProperty biolink:predicate ],
        [ a owl:Restriction ;
            owl:minCardinality 1 ;
            owl:onProperty biolink:object ],
        [ a owl:Restriction ;
            owl:allValuesFrom biolink:ResponseTargetEnum ;
            owl:onProperty biolink:response_target_context_qualifier ],
        [ a owl:Restriction ;
            owl:minCardinality 1 ;
            owl:onProperty biolink:subject ],
        biolink:Association ;
    skos:definition "A statistical association between a disease and a chemical entity where the chemical entity has a therapeutic or adverse effect on the disease progression, symptoms or outcomes in a patient, cell line, or any model system." ;
    skos:inScheme biolink: .

biolink:DiseaseOrPhenotypicFeatureExposure a owl:Class ;
    rdfs:label "disease or phenotypic feature exposure" ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:onProperty linkml:mixins ;
            owl:someValuesFrom biolink:PathologicalEntityMixin ],
        biolink:ExposureEvent ;
    skos:definition "A disease or phenotypic feature state, when viewed as an exposure, represented as a precondition, leading to or influencing an outcome,." ;
    skos:inScheme biolink: .

biolink:DiseaseOrPhenotypicFeatureToGeneticInheritanceAssociation a owl:Class ;
    rdfs:label "disease or phenotypic feature to genetic inheritance association" ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:allValuesFrom xsd:string ;
            owl:onProperty biolink:predicate ],
        [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:object ],
        [ a owl:Restriction ;
            owl:minCardinality 1 ;
            owl:onProperty biolink:object ],
        [ a owl:Restriction ;
            owl:allValuesFrom biolink:GeneticInheritance ;
            owl:onProperty biolink:object ],
        [ a owl:Restriction ;
            owl:onProperty linkml:mixins ;
            owl:someValuesFrom biolink:DiseaseOrPhenotypicFeatureToEntityAssociationMixin ],
        [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:predicate ],
        [ a owl:Restriction ;
            owl:minCardinality 1 ;
            owl:onProperty biolink:predicate ],
        biolink:Association ;
    skos:definition "An association between either a disease or a phenotypic feature and its mode of (genetic) inheritance." ;
    skos:inScheme biolink: .

biolink:DiseaseOrPhenotypicFeatureToLocationAssociation a owl:Class ;
    rdfs:label "disease or phenotypic feature to location association" ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:object ],
        [ a owl:Restriction ;
            owl:onProperty linkml:mixins ;
            owl:someValuesFrom biolink:DiseaseOrPhenotypicFeatureToEntityAssociationMixin ],
        [ a owl:Restriction ;
            owl:allValuesFrom biolink:AnatomicalEntity ;
            owl:onProperty biolink:object ],
        [ a owl:Restriction ;
            owl:minCardinality 1 ;
            owl:onProperty biolink:object ],
        biolink:Association ;
    skos:definition "An association between either a disease or a phenotypic feature and an anatomical entity, where the disease/feature manifests in that site." ;
    skos:inScheme biolink: .

biolink:DiseaseToDiseaseAssociation a owl:Class ;
    rdfs:label "disease to disease association" ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:minCardinality 1 ;
            owl:onProperty biolink:predicate ],
        [ a owl:Restriction ;
            owl:allValuesFrom biolink:Disease ;
            owl:onProperty biolink:subject ],
        [ a owl:Restriction ;
            owl:minCardinality 1 ;
            owl:onProperty biolink:subject ],
        [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:object ],
        [ a owl:Restriction ;
            owl:onProperty linkml:mixins ;
            owl:someValuesFrom biolink:DiseaseToEntityAssociationMixin ],
        [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:subject ],
        [ a owl:Restriction ;
            owl:onProperty linkml:mixins ;
            owl:someValuesFrom biolink:EntityToDiseaseAssociationMixin ],
        [ a owl:Restriction ;
            owl:minCardinality 1 ;
            owl:onProperty biolink:object ],
        [ a owl:Restriction ;
            owl:allValuesFrom xsd:string ;
            owl:onProperty biolink:predicate ],
        [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:predicate ],
        [ a owl:Restriction ;
            owl:allValuesFrom biolink:Disease ;
            owl:onProperty biolink:object ],
        biolink:Association ;
    skos:definition "An association between two diseases. Captures clinical or biological relationships such as comorbidity, sequela, post-infectious complication, shared susceptibility, or differential diagnosis. The precise relationship is carried by the predicate (e.g. ``associated with``, ``contributes to``, ``risk affected by``, ``temporally related to``); use this class whenever both ends of the association are diseases, rather than the more specific ``disease to phenotypic feature association`` (which forces the object to be a phenotypic feature) or a generic ``association``." ;
    skos:inScheme biolink: .

biolink:DiseaseToExposureEventAssociation a owl:Class ;
    rdfs:label "disease to exposure event association" ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:onProperty linkml:mixins ;
            owl:someValuesFrom biolink:DiseaseToEntityAssociationMixin ],
        [ a owl:Restriction ;
            owl:onProperty linkml:mixins ;
            owl:someValuesFrom biolink:EntityToExposureEventAssociationMixin ],
        biolink:Association ;
    skos:definition "An association between an exposure event and a disease." ;
    skos:inScheme biolink: .

biolink:DiseaseToPhenotypicFeatureAssociation a owl:Class ;
    rdfs:label "disease to phenotypic feature association" ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:onProperty linkml:mixins ;
            owl:someValuesFrom biolink:EntityToPhenotypicFeatureAssociationMixin ],
        [ a owl:Restriction ;
            owl:allValuesFrom biolink:PhenotypicFeature ;
            owl:onProperty biolink:object ],
        [ a owl:Restriction ;
            owl:minCardinality 0 ;
            owl:onProperty biolink:onset_qualifier ],
        [ a owl:Restriction ;
            owl:minCardinality 1 ;
            owl:onProperty biolink:object ],
        [ a owl:Restriction ;
            owl:minCardinality 1 ;
            owl:onProperty biolink:subject ],
        [ a owl:Restriction ;
            owl:allValuesFrom biolink:Disease ;
            owl:onProperty biolink:subject ],
        [ a owl:Restriction ;
            owl:onProperty linkml:mixins ;
            owl:someValuesFrom biolink:DiseaseToEntityAssociationMixin ],
        [ a owl:Restriction ;
            owl:onProperty linkml:mixins ;
            owl:someValuesFrom biolink:FrequencyQuantifier ],
        [ a owl:Restriction ;
            owl:allValuesFrom biolink:Onset ;
            owl:onProperty biolink:onset_qualifier ],
        [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:subject ],
        [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:onset_qualifier ],
        [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:object ],
        biolink:Association ;
    skos:closeMatch dcid:DiseaseSymptomAssociation ;
    skos:definition "An association between a disease and a phenotypic feature in which the phenotypic feature is associated with the disease in some way." ;
    skos:inScheme biolink: .

<https://w3id.org/biolink/vocab/DrugAvailabilityEnum#over_the_counter> a owl:Class ;
    rdfs:label "over_the_counter" ;
    rdfs:subClassOf biolink:DrugAvailabilityEnum,
        linkml:PermissibleValue ;
    skos:definition "chemical entity is available over the counter without a prescription." .

<https://w3id.org/biolink/vocab/DrugAvailabilityEnum#prescription> a owl:Class ;
    rdfs:label "prescription" ;
    rdfs:subClassOf biolink:DrugAvailabilityEnum,
        linkml:PermissibleValue ;
    skos:definition "chemical entity is available by prescription." .

<https://w3id.org/biolink/vocab/DrugDeliveryEnum#absorption_through_the_skin> a owl:Class ;
    rdfs:label "absorption_through_the_skin" ;
    rdfs:subClassOf biolink:DrugDeliveryEnum,
        linkml:PermissibleValue .

<https://w3id.org/biolink/vocab/DrugDeliveryEnum#inhalation> a owl:Class ;
    rdfs:label "inhalation" ;
    rdfs:subClassOf biolink:DrugDeliveryEnum,
        linkml:PermissibleValue .

<https://w3id.org/biolink/vocab/DrugDeliveryEnum#intramuscular_injection> a owl:Class ;
    rdfs:label "intramuscular_injection" ;
    rdfs:subClassOf biolink:DrugDeliveryEnum,
        <https://w3id.org/biolink/vocab/DrugDeliveryEnum#injection> .

<https://w3id.org/biolink/vocab/DrugDeliveryEnum#intravenous_injection> a owl:Class ;
    rdfs:label "intravenous_injection" ;
    rdfs:subClassOf biolink:DrugDeliveryEnum,
        <https://w3id.org/biolink/vocab/DrugDeliveryEnum#injection> .

<https://w3id.org/biolink/vocab/DrugDeliveryEnum#oral> a owl:Class ;
    rdfs:label "oral" ;
    rdfs:subClassOf biolink:DrugDeliveryEnum,
        linkml:PermissibleValue .

<https://w3id.org/biolink/vocab/DrugDeliveryEnum#subcutaneous_injection> a owl:Class ;
    rdfs:label "subcutaneous_injection" ;
    rdfs:subClassOf biolink:DrugDeliveryEnum,
        <https://w3id.org/biolink/vocab/DrugDeliveryEnum#injection> .

biolink:DrugLabel a owl:Class ;
    rdfs:label "drug label" ;
    rdfs:subClassOf biolink:Publication ;
    skos:broadMatch NCIT-OBO:C41203 ;
    skos:definition "a document accompanying a drug or its container that provides written, printed or graphic information about the drug, including drug contents, specific instructions or warnings for administration, storage and disposal instructions, etc." ;
    skos:inScheme biolink: .

biolink:DrugToEntityAssociationMixin a owl:Class ;
    rdfs:label "drug to entity association mixin" ;
    rdfs:subClassOf biolink:ChemicalEntityToEntityAssociationMixin ;
    skos:definition "An interaction between a drug and another entity" ;
    skos:inScheme biolink: .

biolink:DrugToGeneAssociation a owl:Class ;
    rdfs:label "drug to gene association" ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:minCardinality 1 ;
            owl:onProperty biolink:object ],
        [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:object ],
        [ a owl:Restriction ;
            owl:onProperty linkml:mixins ;
            owl:someValuesFrom biolink:DrugToEntityAssociationMixin ],
        [ a owl:Restriction ;
            owl:allValuesFrom biolink:GeneOrGeneProduct ;
            owl:onProperty biolink:object ],
        biolink:Association ;
    skos:definition "An interaction between a drug and a gene or gene product." ;
    skos:inScheme biolink: ;
    skos:relatedMatch SIO:001257 .

biolink:DrugToGeneInteractionExposure a owl:Class ;
    rdfs:label "drug to gene interaction exposure" ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:onProperty linkml:mixins ;
            owl:someValuesFrom biolink:GeneGroupingMixin ],
        biolink:DrugExposure ;
    skos:definition "drug to gene interaction exposure is a drug exposure is where the interactions of the drug with specific genes are known to constitute an 'exposure' to the organism, leading to or influencing an outcome." ;
    skos:inScheme biolink: .

<https://w3id.org/biolink/vocab/DruggableGeneCategoryEnum#tbio> a owl:Class ;
    rdfs:label "tbio" ;
    rdfs:subClassOf biolink:DruggableGeneCategoryEnum,
        linkml:PermissibleValue ;
    skos:definition "These targets have activities in ChEMBL, Guide to Pharmacology or DrugCentral that satisfy the activity thresholds detailed below." .

<https://w3id.org/biolink/vocab/DruggableGeneCategoryEnum#tchem> a owl:Class ;
    rdfs:label "tchem" ;
    rdfs:subClassOf biolink:DruggableGeneCategoryEnum,
        linkml:PermissibleValue ;
    skos:definition "These targets do not have known drug or small molecule activities that satisfy the activity thresholds detailed below AND satisfy one or more of the following criteria: target is above the cutoff criteria for the target is annotated with a Gene Ontology Molecular Function or Biological Process leaf term(s) with an Experimental Evidence code" .

<https://w3id.org/biolink/vocab/DruggableGeneCategoryEnum#tclin> a owl:Class ;
    rdfs:label "tclin" ;
    rdfs:subClassOf biolink:DruggableGeneCategoryEnum,
        linkml:PermissibleValue ;
    skos:definition "These targets have activities in DrugCentral (ie. approved drugs) with known mechanism of action." .

<https://w3id.org/biolink/vocab/DruggableGeneCategoryEnum#tdark> a owl:Class ;
    rdfs:label "tdark" ;
    rdfs:subClassOf biolink:DruggableGeneCategoryEnum,
        linkml:PermissibleValue ;
    skos:definition "These are targets about which virtually nothing is known. They do not have known drug or small molecule activities that satisfy the activity thresholds detailed below AND satisfy two or more of the following criteria: A PubMed text-mining score from Jensen Lab less than 5, greater than or equal TO 3 Gene RIFs, or less than or equal to 50 Antibodies available according to http://antibodypedia.com." .

biolink:DruggableGeneToDiseaseAssociation a owl:Class ;
    rdfs:label "druggable gene to disease association" ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:minCardinality 1 ;
            owl:onProperty biolink:predicate ],
        [ a owl:Restriction ;
            owl:onProperty linkml:mixins ;
            owl:someValuesFrom biolink:EntityToDiseaseAssociationMixin ],
        [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:druggable_gene_category ],
        [ a owl:Restriction ;
            owl:allValuesFrom xsd:string ;
            owl:onProperty biolink:predicate ],
        [ a owl:Restriction ;
            owl:minCardinality 1 ;
            owl:onProperty biolink:subject ],
        [ a owl:Restriction ;
            owl:onProperty linkml:mixins ;
            owl:someValuesFrom biolink:GeneToEntityAssociationMixin ],
        [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:predicate ],
        [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:subject ],
        [ a owl:Restriction ;
            owl:allValuesFrom biolink:GeneOrGeneProduct ;
            owl:onProperty biolink:subject ],
        [ a owl:Restriction ;
            owl:allValuesFrom biolink:DruggableGeneCategoryEnum ;
            owl:onProperty biolink:druggable_gene_category ],
        [ a owl:Restriction ;
            owl:minCardinality 0 ;
            owl:onProperty biolink:druggable_gene_category ],
        biolink:GeneToDiseaseAssociation ;
    skos:definition "An association between a gene (or gene product) and a disease in which the gene is classified by its druggability (e.g., via the IDG/Pharos target development-level tiers)." ;
    skos:inScheme biolink: .

<https://w3id.org/biolink/vocab/EffectTypeEnum#cohens_d> a owl:Class ;
    rdfs:label "cohens_d" ;
    rdfs:subClassOf biolink:EffectTypeEnum,
        <https://w3id.org/biolink/vocab/EffectTypeEnum#standardized_mean_difference> ;
    skos:closeMatch <http://purl.obolibrary.org/obo/STATO_0000618> ;
    skos:definition "A standardized mean difference using the square root of the average of the two group variances as the denominator, with a small-sample correction for n < 50." .

<https://w3id.org/biolink/vocab/EffectTypeEnum#eta_squared> a owl:Class ;
    rdfs:label "eta_squared" ;
    rdfs:subClassOf biolink:EffectTypeEnum,
        linkml:PermissibleValue ;
    skos:closeMatch <http://purl.obolibrary.org/obo/STATO_0000317> ;
    skos:definition "The proportion of total variance in the dependent variable attributable to a predictor in the sample (a biased estimator analogous to R-squared)." .

<https://w3id.org/biolink/vocab/EffectTypeEnum#glasss_delta> a owl:Class ;
    rdfs:label "glasss_delta" ;
    rdfs:subClassOf biolink:EffectTypeEnum,
        <https://w3id.org/biolink/vocab/EffectTypeEnum#standardized_mean_difference> ;
    skos:closeMatch <http://purl.obolibrary.org/obo/STATO_0000320> ;
    skos:definition "A standardized mean difference using only the control group's standard deviation as the denominator, preferred when group variances differ substantially." .

<https://w3id.org/biolink/vocab/EffectTypeEnum#goodman_kruskal_gamma> a owl:Class ;
    rdfs:label "goodman_kruskal_gamma" ;
    rdfs:subClassOf biolink:EffectTypeEnum,
        <https://w3id.org/biolink/vocab/EffectTypeEnum#correlation_coefficient> ;
    skos:closeMatch <http://purl.obolibrary.org/obo/STATO_0000612> ;
    skos:definition "A rank correlation measure for ordinal or continuous variables based on the difference between concordant and discordant pairs, excluding ties." .

<https://w3id.org/biolink/vocab/EffectTypeEnum#hazard_ratio> a owl:Class ;
    rdfs:label "hazard_ratio" ;
    rdfs:subClassOf biolink:EffectTypeEnum,
        linkml:PermissibleValue ;
    skos:closeMatch <http://purl.obolibrary.org/obo/STATO_0000677> ;
    skos:definition "The ratio of hazard rates between two groups over time, commonly reported in survival analysis and time-to-event omics studies." .

<https://w3id.org/biolink/vocab/EffectTypeEnum#hedges_g> a owl:Class ;
    rdfs:label "hedges_g" ;
    rdfs:subClassOf biolink:EffectTypeEnum,
        <https://w3id.org/biolink/vocab/EffectTypeEnum#standardized_mean_difference> ;
    skos:closeMatch <http://purl.obolibrary.org/obo/STATO_0000319> ;
    skos:definition "A standardized mean difference with a Gamma-function correction on the pooled standard deviation to reduce small-sample bias." .

<https://w3id.org/biolink/vocab/EffectTypeEnum#inverse_variance_weighted> a owl:Class ;
    rdfs:label "inverse_variance_weighted" ;
    rdfs:subClassOf biolink:EffectTypeEnum,
        linkml:PermissibleValue ;
    skos:definition "A Mendelian randomization estimator that combines per-variant Wald ratios using inverse-variance weighting, assuming all instruments are valid (no horizontal pleiotropy)." .

<https://w3id.org/biolink/vocab/EffectTypeEnum#kendalls_tau> a owl:Class ;
    rdfs:label "kendalls_tau" ;
    rdfs:subClassOf biolink:EffectTypeEnum,
        <https://w3id.org/biolink/vocab/EffectTypeEnum#correlation_coefficient> ;
    skos:closeMatch <http://purl.obolibrary.org/obo/STATO_0000240> ;
    skos:definition "A rank correlation coefficient based on concordant and discordant pairs, suitable for ordinal data." .

<https://w3id.org/biolink/vocab/EffectTypeEnum#log2_fold_change> a owl:Class ;
    rdfs:label "log2_fold_change" ;
    rdfs:subClassOf biolink:EffectTypeEnum,
        linkml:PermissibleValue ;
    skos:closeMatch <http://purl.obolibrary.org/obo/STATO_0000169> ;
    skos:definition "The base-2 logarithm of the ratio of a quantity (e.g. gene expression, protein abundance, metabolite concentration) between two conditions. The standard effect size in differential expression and differential abundance analyses across transcriptomics, proteomics, and metabolomics." .

<https://w3id.org/biolink/vocab/EffectTypeEnum#matthews_correlation_coefficient> a owl:Class ;
    rdfs:label "matthews_correlation_coefficient" ;
    rdfs:subClassOf biolink:EffectTypeEnum,
        <https://w3id.org/biolink/vocab/EffectTypeEnum#correlation_coefficient> ;
    skos:closeMatch <http://purl.obolibrary.org/obo/STATO_0000524> ;
    skos:definition "A correlation-based measure of binary classification quality (also known as the phi coefficient), ranging from -1 to +1." .

<https://w3id.org/biolink/vocab/EffectTypeEnum#mr_egger> a owl:Class ;
    rdfs:label "mr_egger" ;
    rdfs:subClassOf biolink:EffectTypeEnum,
        linkml:PermissibleValue ;
    skos:definition "A Mendelian randomization estimator based on Egger regression that allows for directional horizontal pleiotropy by fitting an intercept term; a non-zero intercept indicates pleiotropic bias." .

<https://w3id.org/biolink/vocab/EffectTypeEnum#odds_ratio> a owl:Class ;
    rdfs:label "odds_ratio" ;
    rdfs:subClassOf biolink:EffectTypeEnum,
        linkml:PermissibleValue ;
    skos:closeMatch <http://purl.obolibrary.org/obo/STATO_0000182> ;
    skos:definition "The ratio of the odds of an outcome in an exposed group to the odds in an unexposed group, measuring association strength between two binary variables." .

<https://w3id.org/biolink/vocab/EffectTypeEnum#omega_squared> a owl:Class ;
    rdfs:label "omega_squared" ;
    rdfs:subClassOf biolink:EffectTypeEnum,
        linkml:PermissibleValue ;
    skos:closeMatch <http://purl.obolibrary.org/obo/STATO_0000318> ;
    skos:definition "A less biased estimator of the proportion of variance explained by a predictor, providing a better population-level estimate than eta-squared." .

<https://w3id.org/biolink/vocab/EffectTypeEnum#pearsons_r> a owl:Class ;
    rdfs:label "pearsons_r" ;
    rdfs:subClassOf biolink:EffectTypeEnum,
        <https://w3id.org/biolink/vocab/EffectTypeEnum#correlation_coefficient> ;
    skos:closeMatch <http://purl.obolibrary.org/obo/STATO_0000280> ;
    skos:definition "A parametric correlation coefficient for two continuous, normally distributed variables with a linear relationship." .

<https://w3id.org/biolink/vocab/EffectTypeEnum#polychoric_correlation> a owl:Class ;
    rdfs:label "polychoric_correlation" ;
    rdfs:subClassOf biolink:EffectTypeEnum,
        <https://w3id.org/biolink/vocab/EffectTypeEnum#correlation_coefficient> ;
    skos:closeMatch <http://purl.obolibrary.org/obo/STATO_0000269> ;
    skos:definition "A correlation coefficient estimating the association between two latent continuous variables from observed ordinal data." .

<https://w3id.org/biolink/vocab/EffectTypeEnum#r2_linkage_disequilibrium> a owl:Class ;
    rdfs:label "r2_linkage_disequilibrium" ;
    rdfs:subClassOf biolink:EffectTypeEnum,
        <https://w3id.org/biolink/vocab/EffectTypeEnum#correlation_coefficient> ;
    skos:closeMatch <http://purl.obolibrary.org/obo/STATO_0000123> ;
    skos:definition "A squared correlation coefficient over two dichotomous variables used as a measure of linkage disequilibrium." .

<https://w3id.org/biolink/vocab/EffectTypeEnum#regression_coefficient> a owl:Class ;
    rdfs:label "regression_coefficient" ;
    rdfs:subClassOf biolink:EffectTypeEnum,
        linkml:PermissibleValue ;
    skos:closeMatch <http://purl.obolibrary.org/obo/STATO_0000565> ;
    skos:definition "The coefficient of an independent variable in a regression model, representing the expected change in the dependent variable per unit change in the predictor. Commonly reported as a beta coefficient in eQTL, pQTL, mQTL, and GWAS analyses." .

<https://w3id.org/biolink/vocab/EffectTypeEnum#relative_risk> a owl:Class ;
    rdfs:label "relative_risk" ;
    rdfs:subClassOf biolink:EffectTypeEnum,
        linkml:PermissibleValue ;
    skos:closeMatch <http://purl.obolibrary.org/obo/STATO_0000245> ;
    skos:definition "The ratio of event probability in an exposed group to event probability in an unexposed group (also called risk ratio)." .

<https://w3id.org/biolink/vocab/EffectTypeEnum#root_mean_square_standardized_effect> a owl:Class ;
    rdfs:label "root_mean_square_standardized_effect" ;
    rdfs:subClassOf biolink:EffectTypeEnum,
        linkml:PermissibleValue ;
    skos:closeMatch <http://purl.obolibrary.org/obo/STATO_0000316> ;
    skos:definition "The square root of the average of squared standardized effects in an analysis of variance context (RMSSE, Psi)." .

<https://w3id.org/biolink/vocab/EffectTypeEnum#spearmans_rho> a owl:Class ;
    rdfs:label "spearmans_rho" ;
    rdfs:subClassOf biolink:EffectTypeEnum,
        <https://w3id.org/biolink/vocab/EffectTypeEnum#correlation_coefficient> ;
    skos:closeMatch <http://purl.obolibrary.org/obo/STATO_0000201> ;
    skos:definition "A nonparametric rank correlation coefficient measuring monotonic dependence between two variables." .

<https://w3id.org/biolink/vocab/EffectTypeEnum#strictly_standardized_mean_difference> a owl:Class ;
    rdfs:label "strictly_standardized_mean_difference" ;
    rdfs:subClassOf biolink:EffectTypeEnum,
        <https://w3id.org/biolink/vocab/EffectTypeEnum#standardized_mean_difference> ;
    skos:closeMatch <http://purl.obolibrary.org/obo/STATO_0000135> ;
    skos:definition "The ratio of the mean difference to the standard deviation of the difference between two groups (SSMD), widely used in high-content screening for hit selection and quality control." .

<https://w3id.org/biolink/vocab/EffectTypeEnum#wald_ratio> a owl:Class ;
    rdfs:label "wald_ratio" ;
    rdfs:subClassOf biolink:EffectTypeEnum,
        linkml:PermissibleValue ;
    skos:definition "A single-variant Mendelian randomization estimator computed as the ratio of the genetic variant-outcome association to the genetic variant-exposure association." .

<https://w3id.org/biolink/vocab/EffectTypeEnum#weighted_median> a owl:Class ;
    rdfs:label "weighted_median" ;
    rdfs:subClassOf biolink:EffectTypeEnum,
        linkml:PermissibleValue ;
    skos:definition "A robust Mendelian randomization estimator that provides a consistent causal estimate when at least 50% of the instrument weight comes from valid variants." .

biolink:EntityToDiseaseAssociation a owl:Class ;
    rdfs:label "entity to disease association" ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:onProperty linkml:mixins ;
            owl:someValuesFrom biolink:EntityToDiseaseAssociationMixin ],
        [ a owl:Restriction ;
            owl:onProperty linkml:mixins ;
            owl:someValuesFrom biolink:ClinicalTrialAndRegulatoryApprovalContextMixin ],
        biolink:Association ;
    skos:definition "An association between any entity and a disease, capturing clinical context such as approval status, research phase, regulatory approvals, and number of cases." ;
    skos:inScheme biolink: .

biolink:EntityToExposureEventAssociationMixin a owl:Class ;
    rdfs:label "entity to exposure event association mixin" ;
    rdfs:subClassOf <https://w3id.org/linkml/ClassDefinition#Mixin> ;
    skos:definition "An association between some entity and an exposure event." ;
    skos:inScheme biolink: .

biolink:EntityToOutcomeAssociationMixin a owl:Class ;
    rdfs:label "entity to outcome association mixin" ;
    rdfs:subClassOf <https://w3id.org/linkml/ClassDefinition#Mixin> ;
    skos:definition "An association between some entity and an outcome" ;
    skos:inScheme biolink: .

biolink:EntityToPhenotypicFeatureAssociation a owl:Class ;
    rdfs:label "entity to phenotypic feature association" ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:onProperty linkml:mixins ;
            owl:someValuesFrom biolink:EntityToPhenotypicFeatureAssociationMixin ],
        [ a owl:Restriction ;
            owl:onProperty linkml:mixins ;
            owl:someValuesFrom biolink:ClinicalTrialAndRegulatoryApprovalContextMixin ],
        biolink:Association ;
    skos:definition "An association between any entity and a phenotypic feature, capturing clinical context such as approval status, research phase, regulatory approvals, and number of cases." ;
    skos:inScheme biolink: .

biolink:EnvironmentalFeature a owl:Class ;
    rdfs:label "environmental feature" ;
    rdfs:subClassOf biolink:PlanetaryEntity ;
    skos:definition "A system or entity in the natural environment that has the disposition to environ one or more material entities." ;
    skos:exactMatch <http://purl.obolibrary.org/obo/ENVO_01000254> ;
    skos:inScheme biolink: .

biolink:EnvironmentalFoodContaminant a owl:Class ;
    rdfs:label "environmental food contaminant" ;
    rdfs:subClassOf biolink:ChemicalEntity ;
    skos:definition "Any unwanted chemical in food. The term includes agrochemicals and industrial chemicals that may contaminate foodstuffs during their production, transportation or storage." ;
    skos:exactMatch <http://purl.obolibrary.org/obo/CHEBI_78299> ;
    skos:inScheme biolink: ;
    skos:relatedMatch <http://purl.obolibrary.org/obo/CHEBI_78299> .

biolink:EnvironmentalProcess a owl:Class ;
    rdfs:label "environmental process" ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:onProperty linkml:mixins ;
            owl:someValuesFrom biolink:Occurrent ],
        biolink:PlanetaryEntity ;
    skos:definition "A process that occurs within or involves the components of an environmental system." ;
    skos:exactMatch <http://purl.obolibrary.org/obo/ENVO_02500000> ;
    skos:inScheme biolink: .

biolink:EpigenomicEntity a owl:Class ;
    rdfs:label "epigenomic entity" ;
    rdfs:subClassOf <https://w3id.org/linkml/ClassDefinition#Mixin> ;
    skos:definition "A mixin for entities that represent epigenomic modifications or features associated with heritable changes in gene expression that do not involve changes to the DNA sequence itself." ;
    skos:inScheme biolink: .

biolink:Event a owl:Class ;
    rdfs:label "event" ;
    rdfs:subClassOf biolink:NamedThing ;
    skos:definition "Something that happens at a given place and time." ;
    skos:exactMatch STY:T051,
        <http://purl.obolibrary.org/obo/NCIT_C25499> ;
    skos:inScheme biolink: .

biolink:ExonToTranscriptRelationship a owl:Class ;
    rdfs:label "exon to transcript relationship" ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:allValuesFrom biolink:Exon ;
            owl:onProperty biolink:subject ],
        [ a owl:Restriction ;
            owl:minCardinality 1 ;
            owl:onProperty biolink:object ],
        [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:object ],
        [ a owl:Restriction ;
            owl:minCardinality 1 ;
            owl:onProperty biolink:subject ],
        [ a owl:Restriction ;
            owl:allValuesFrom biolink:Transcript ;
            owl:onProperty biolink:object ],
        [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:subject ],
        biolink:SequenceFeatureRelationship ;
    skos:definition "A transcript is formed from multiple exons" ;
    skos:inScheme biolink: .

biolink:ExposureEventToOutcomeAssociation a owl:Class ;
    rdfs:label "exposure event to outcome association" ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:minCardinality 0 ;
            owl:onProperty biolink:population_context_qualifier ],
        [ a owl:Restriction ;
            owl:minCardinality 0 ;
            owl:onProperty biolink:temporal_context_qualifier ],
        [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:temporal_context_qualifier ],
        [ a owl:Restriction ;
            owl:onProperty linkml:mixins ;
            owl:someValuesFrom biolink:EntityToOutcomeAssociationMixin ],
        [ a owl:Restriction ;
            owl:allValuesFrom biolink:PopulationOfIndividualOrganisms ;
            owl:onProperty biolink:population_context_qualifier ],
        [ a owl:Restriction ;
            owl:allValuesFrom xsd:string ;
            owl:onProperty biolink:temporal_context_qualifier ],
        [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:population_context_qualifier ],
        biolink:Association ;
    skos:definition "An association between an exposure event and an outcome." ;
    skos:inScheme biolink: .

biolink:ExposureEventToPhenotypicFeatureAssociation a owl:Class ;
    rdfs:label "exposure event to phenotypic feature association" ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:allValuesFrom biolink:ExposureEvent ;
            owl:onProperty biolink:subject ],
        [ a owl:Restriction ;
            owl:minCardinality 1 ;
            owl:onProperty biolink:subject ],
        [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:subject ],
        [ a owl:Restriction ;
            owl:onProperty linkml:mixins ;
            owl:someValuesFrom biolink:EntityToPhenotypicFeatureAssociationMixin ],
        biolink:Association ;
    skos:definition "Any association between an environment and a phenotypic feature, where being in the environment influences the phenotype." ;
    skos:inScheme biolink: .

<https://w3id.org/biolink/vocab/FDAIDAAdverseEventEnum#life_threatening_adverse_event> a owl:Class ;
    rdfs:label "life_threatening_adverse_event" ;
    rdfs:subClassOf biolink:FDAIDAAdverseEventEnum,
        linkml:PermissibleValue ;
    skos:definition "An adverse event or suspected adverse reaction is considered 'life-threatening' if, in the view of either the investigator or sponsor, its occurrence places the patient or subject at immediate risk of death. It does not include an adverse event or suspected adverse reaction that, had it occurred in a more severe form, might have caused death." .

<https://w3id.org/biolink/vocab/FDAIDAAdverseEventEnum#serious_adverse_event> a owl:Class ;
    rdfs:label "serious_adverse_event" ;
    rdfs:subClassOf biolink:FDAIDAAdverseEventEnum,
        linkml:PermissibleValue ;
    skos:definition "An adverse event or suspected adverse reaction is considered 'serious' if, in the view of either the investigator or sponsor, it results in any of the following outcomes: Death, a life-threatening adverse event, inpatient hospitalization or prolongation of existing hospitalization, a persistent or significant incapacity or substantial disruption of the ability to conduct normal life functions, or a congenital anomaly/birth defect. Important medical events that may not result in death, be life-threatening, or require hospitalization may be considered serious when, based upon appropriate medical judgment, they may jeopardize the patient or subject and may require medical or surgical intervention to prevent one of the outcomes listed in this definition. Examples of such medical events include allergic bronchospasm requiring intensive treatment in an emergency room or at home, blood dyscrasias or convulsions that do not result in inpatient hospitalization, or the development of drug dependency or drug abuse." .

<https://w3id.org/biolink/vocab/FDAIDAAdverseEventEnum#suspected_adverse_reaction> a owl:Class ;
    rdfs:label "suspected_adverse_reaction" ;
    rdfs:subClassOf biolink:FDAIDAAdverseEventEnum,
        linkml:PermissibleValue ;
    skos:definition "means any adverse event for which there is a reasonable possibility that the drug caused the adverse event. For the purposes of IND safety reporting, 'reasonable possibility' means there is evidence to suggest a causal relationship between the drug and the adverse event. Suspected adverse reaction implies a lesser degree of certainty about causality than adverse reaction, which means any adverse event caused by a drug." .

<https://w3id.org/biolink/vocab/FDAIDAAdverseEventEnum#unexpected_adverse_event> a owl:Class ;
    rdfs:label "unexpected_adverse_event" ;
    rdfs:subClassOf biolink:FDAIDAAdverseEventEnum,
        linkml:PermissibleValue ;
    skos:definition "An adverse event or suspected adverse reaction is considered 'unexpected' if it is not listed in the investigator brochure or is not listed at the specificity or severity that has been observed; or, if an investigator brochure is not required or available, is not consistent with the risk information described in the general investigational plan or elsewhere in the current application, as amended. For example, under this definition, hepatic necrosis would be unexpected (by virtue of greater severity) if the investigator brochure referred only to elevated hepatic enzymes or hepatitis. Similarly, cerebral thromboembolism and cerebral vasculitis would be unexpected (by virtue of greater specificity) if the investigator brochure listed only cerebral vascular accidents. 'Unexpected', as used in this definition, also refers to adverse events or suspected adverse reactions that are mentioned in the investigator brochure as occurring with a class of drugs or as anticipated from the pharmacological properties of the drug, but are not specifically mentioned as occurring with the particular drug under investigation." .

biolink:FeatureOrDiseaseQualifiersToEntityMixin a owl:Class ;
    rdfs:label "feature or disease qualifiers to entity mixin" ;
    rdfs:subClassOf biolink:FrequencyQualifierMixin ;
    skos:definition "Qualifiers for disease or phenotype to entity associations." ;
    skos:inScheme biolink: .

biolink:Food a owl:Class ;
    rdfs:label "food" ;
    rdfs:subClassOf biolink:ChemicalMixture ;
    skos:definition "A substance of plant, animal, or artificial origin consumed by a living organism to provide essential nutrients, energy, and support growth and the processes of life, or to satisfy other health needs or provide a social or organoleptic experience." ;
    skos:exactMatch <http://purl.obolibrary.org/obo/CHEBI_33290>,
        <http://purl.obolibrary.org/obo/FOODON_00002403> ;
    skos:inScheme biolink: .

biolink:FoodAdditive a owl:Class ;
    rdfs:label "food additive" ;
    rdfs:subClassOf biolink:ChemicalEntity ;
    skos:definition "Any substance which is added to food to preserve or enhance its flavour and/or appearance." ;
    skos:exactMatch <http://purl.obolibrary.org/obo/CHEBI_64047> ;
    skos:inScheme biolink: ;
    skos:relatedMatch <http://purl.obolibrary.org/obo/CHEBI_64047> .

biolink:Fungus a owl:Class ;
    rdfs:label "fungus" ;
    rdfs:subClassOf biolink:CellularOrganism ;
    skos:exactMatch STY:T004,
        <http://purl.obolibrary.org/obo/FOODON_03411261>,
        <http://purl.obolibrary.org/obo/NCIT_C14209> ;
    skos:inScheme biolink: ;
    skos:narrowMatch <http://purl.obolibrary.org/obo/FOODON_03315605>,
        <http://purl.obolibrary.org/obo/NCBITaxon_1670606> .

biolink:GeneAffectsChemicalAssociation a owl:Class ;
    rdfs:label "gene affects chemical association" ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:subject_context_qualifier ],
        [ a owl:Restriction ;
            owl:minCardinality 0 ;
            owl:onProperty biolink:object_part_qualifier ],
        [ a owl:Restriction ;
            owl:allValuesFrom biolink:ChemicalEntity ;
            owl:onProperty biolink:object ],
        [ a owl:Restriction ;
            owl:allValuesFrom biolink:GeneOrGeneProductOrChemicalPartQualifierEnum ;
            owl:onProperty biolink:subject_part_qualifier ],
        [ a owl:Restriction ;
            owl:minCardinality 0 ;
            owl:onProperty biolink:object_derivative_qualifier ],
        [ a owl:Restriction ;
            owl:allValuesFrom biolink:DirectionQualifierEnum ;
            owl:onProperty biolink:subject_direction_qualifier ],
        [ a owl:Restriction ;
            owl:minCardinality 0 ;
            owl:onProperty biolink:subject_aspect_qualifier ],
        [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:predicate ],
        [ a owl:Restriction ;
            owl:minCardinality 1 ;
            owl:onProperty biolink:predicate ],
        [ a owl:Restriction ;
            owl:allValuesFrom biolink:GeneOrGeneProductOrChemicalPartQualifierEnum ;
            owl:onProperty biolink:object_part_qualifier ],
        [ a owl:Restriction ;
            owl:allValuesFrom biolink:GeneOrGeneProductOrChemicalEntityAspectEnum ;
            owl:onProperty biolink:subject_aspect_qualifier ],
        [ a owl:Restriction ;
            owl:minCardinality 0 ;
            owl:onProperty biolink:subject_derivative_qualifier ],
        [ a owl:Restriction ;
            owl:allValuesFrom biolink:AnatomicalEntity ;
            owl:onProperty biolink:subject_context_qualifier ],
        [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:object_aspect_qualifier ],
        [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:object_direction_qualifier ],
        [ a owl:Restriction ;
            owl:allValuesFrom biolink:CausalMechanismQualifierEnum ;
            owl:onProperty biolink:causal_mechanism_qualifier ],
        [ a owl:Restriction ;
            owl:allValuesFrom biolink:ChemicalEntityOrGeneOrGeneProduct ;
            owl:onProperty biolink:subject ],
        [ a owl:Restriction ;
            owl:minCardinality 0 ;
            owl:onProperty biolink:species_context_qualifier ],
        [ a owl:Restriction ;
            owl:allValuesFrom biolink:ChemicalEntityDerivativeEnum ;
            owl:onProperty biolink:object_derivative_qualifier ],
        [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:subject_aspect_qualifier ],
        [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:subject_derivative_qualifier ],
        [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:qualified_predicate ],
        [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:causal_mechanism_qualifier ],
        [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:subject_direction_qualifier ],
        [ a owl:Restriction ;
            owl:minCardinality 1 ;
            owl:onProperty biolink:object ],
        [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:subject_part_qualifier ],
        [ a owl:Restriction ;
            owl:allValuesFrom xsd:string ;
            owl:onProperty biolink:predicate ],
        [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:object_part_qualifier ],
        [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:subject_form_or_variant_qualifier ],
        [ a owl:Restriction ;
            owl:minCardinality 0 ;
            owl:onProperty biolink:subject_direction_qualifier ],
        [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:species_context_qualifier ],
        [ a owl:Restriction ;
            owl:minCardinality 0 ;
            owl:onProperty biolink:object_form_or_variant_qualifier ],
        [ a owl:Restriction ;
            owl:minCardinality 0 ;
            owl:onProperty biolink:qualified_predicate ],
        [ a owl:Restriction ;
            owl:minCardinality 0 ;
            owl:onProperty biolink:object_context_qualifier ],
        [ a owl:Restriction ;
            owl:minCardinality 0 ;
            owl:onProperty biolink:object_aspect_qualifier ],
        [ a owl:Restriction ;
            owl:allValuesFrom biolink:AnatomicalEntity ;
            owl:onProperty biolink:object_context_qualifier ],
        [ a owl:Restriction ;
            owl:minCardinality 1 ;
            owl:onProperty biolink:subject ],
        [ a owl:Restriction ;
            owl:allValuesFrom biolink:DirectionQualifierEnum ;
            owl:onProperty biolink:object_direction_qualifier ],
        [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:object_form_or_variant_qualifier ],
        [ a owl:Restriction ;
            owl:allValuesFrom xsd:string ;
            owl:onProperty biolink:subject_derivative_qualifier ],
        [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:object_context_qualifier ],
        [ a owl:Restriction ;
            owl:allValuesFrom biolink:AnatomicalEntity ;
            owl:onProperty biolink:anatomical_context_qualifier ],
        [ a owl:Restriction ;
            owl:allValuesFrom biolink:OrganismTaxon ;
            owl:onProperty biolink:species_context_qualifier ],
        [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:subject ],
        [ a owl:Restriction ;
            owl:minCardinality 0 ;
            owl:onProperty biolink:subject_part_qualifier ],
        [ a owl:Restriction ;
            owl:minCardinality 0 ;
            owl:onProperty biolink:causal_mechanism_qualifier ],
        [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:object ],
        [ a owl:Restriction ;
            owl:allValuesFrom biolink:GeneOrGeneProductOrChemicalEntityAspectEnum ;
            owl:onProperty biolink:object_aspect_qualifier ],
        [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:object_derivative_qualifier ],
        [ a owl:Restriction ;
            owl:allValuesFrom biolink:ChemicalOrGeneOrGeneProductFormOrVariantEnum ;
            owl:onProperty biolink:subject_form_or_variant_qualifier ],
        [ a owl:Restriction ;
            owl:minCardinality 0 ;
            owl:onProperty biolink:subject_form_or_variant_qualifier ],
        [ a owl:Restriction ;
            owl:allValuesFrom xsd:anyURI ;
            owl:onProperty biolink:qualified_predicate ],
        [ a owl:Restriction ;
            owl:minCardinality 0 ;
            owl:onProperty biolink:anatomical_context_qualifier ],
        [ a owl:Restriction ;
            owl:allValuesFrom biolink:ChemicalOrGeneOrGeneProductFormOrVariantEnum ;
            owl:onProperty biolink:object_form_or_variant_qualifier ],
        [ a owl:Restriction ;
            owl:minCardinality 0 ;
            owl:onProperty biolink:object_direction_qualifier ],
        [ a owl:Restriction ;
            owl:minCardinality 0 ;
            owl:onProperty biolink:subject_context_qualifier ],
        biolink:Association ;
    skos:definition "Describes an effect that a gene or gene product has on a chemical entity (e.g. an impact of on its abundance, activity, localization, processing, transport, etc.)" ;
    skos:inScheme biolink: .

biolink:GeneAsAModelOfDiseaseAssociation a owl:Class ;
    rdfs:label "gene as a model of disease association" ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:subject ],
        [ a owl:Restriction ;
            owl:minCardinality 1 ;
            owl:onProperty biolink:subject ],
        [ a owl:Restriction ;
            owl:allValuesFrom biolink:GeneOrGeneProduct ;
            owl:onProperty biolink:subject ],
        [ a owl:Restriction ;
            owl:onProperty linkml:mixins ;
            owl:someValuesFrom biolink:EntityToDiseaseAssociationMixin ],
        [ a owl:Restriction ;
            owl:onProperty linkml:mixins ;
            owl:someValuesFrom biolink:ModelToDiseaseAssociationMixin ],
        biolink:GeneToDiseaseAssociation ;
    skos:definition "An association in which a gene (e.g., a model-organism ortholog of a known disease gene) serves as a model of a human disease - for example, because mutants of the gene recapitulate core features of the disease." ;
    skos:inScheme biolink: .

biolink:GeneFamilyToGeneOrGeneProductOrGeneFamilyAssociation a owl:Class ;
    rdfs:label "gene family to gene or gene product or gene family association" ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:object ],
        [ a owl:Restriction ;
            owl:allValuesFrom xsd:string ;
            owl:onProperty biolink:predicate ],
        [ a owl:Restriction ;
            owl:minCardinality 1 ;
            owl:onProperty biolink:subject ],
        [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:predicate ],
        [ a owl:Restriction ;
            owl:allValuesFrom biolink:GeneFamily ;
            owl:onProperty biolink:subject ],
        [ a owl:Restriction ;
            owl:minCardinality 1 ;
            owl:onProperty biolink:object ],
        [ a owl:Restriction ;
            owl:allValuesFrom biolink:GeneOrGeneProduct ;
            owl:onProperty biolink:object ],
        [ a owl:Restriction ;
            owl:minCardinality 1 ;
            owl:onProperty biolink:predicate ],
        [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:subject ],
        biolink:Association ;
    skos:definition "Relationship between a gene family and a contained gene or gene product or gene family." ;
    skos:inScheme biolink: .

biolink:GeneHasVariantThatContributesToDiseaseAssociation a owl:Class ;
    rdfs:label "gene has variant that contributes to disease association" ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:minCardinality 1 ;
            owl:onProperty biolink:predicate ],
        [ a owl:Restriction ;
            owl:allValuesFrom biolink:GeneOrGeneProduct ;
            owl:onProperty biolink:subject ],
        [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:subject ],
        [ a owl:Restriction ;
            owl:minCardinality 1 ;
            owl:onProperty biolink:subject ],
        [ a owl:Restriction ;
            owl:minCardinality 1 ;
            owl:onProperty biolink:object ],
        [ a owl:Restriction ;
            owl:allValuesFrom biolink:Disease ;
            owl:onProperty biolink:object ],
        [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:object ],
        [ a owl:Restriction ;
            owl:allValuesFrom xsd:string ;
            owl:onProperty biolink:subject_form_or_variant_qualifier ],
        [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:predicate ],
        [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:subject_form_or_variant_qualifier ],
        [ a owl:Restriction ;
            owl:allValuesFrom xsd:string ;
            owl:onProperty biolink:predicate ],
        [ a owl:Restriction ;
            owl:minCardinality 0 ;
            owl:onProperty biolink:subject_form_or_variant_qualifier ],
        biolink:GeneToDiseaseAssociation ;
    skos:definition "A gene-to-disease association that is asserted on the grounds that the gene harbours a sequence variant that contributes to the disease. Qualifies the gene with the form or variant that underlies the contribution." ;
    skos:inScheme biolink: .

<https://w3id.org/biolink/vocab/GeneOrGeneProductOrChemicalEntityAspectEnum#ADP-ribosylation> a owl:Class ;
    rdfs:label "ADP-ribosylation" ;
    rdfs:subClassOf biolink:GeneOrGeneProductOrChemicalEntityAspectEnum,
        <https://w3id.org/biolink/vocab/GeneOrGeneProductOrChemicalEntityAspectEnum#molecular_modification> .

<https://w3id.org/biolink/vocab/GeneOrGeneProductOrChemicalEntityAspectEnum#absorption> a owl:Class ;
    rdfs:label "absorption" ;
    rdfs:subClassOf biolink:GeneOrGeneProductOrChemicalEntityAspectEnum,
        linkml:PermissibleValue .

<https://w3id.org/biolink/vocab/GeneOrGeneProductOrChemicalEntityAspectEnum#acetylation> a owl:Class ;
    rdfs:label "acetylation" ;
    rdfs:subClassOf biolink:GeneOrGeneProductOrChemicalEntityAspectEnum,
        <https://w3id.org/biolink/vocab/GeneOrGeneProductOrChemicalEntityAspectEnum#molecular_modification> .

<https://w3id.org/biolink/vocab/GeneOrGeneProductOrChemicalEntityAspectEnum#activity> a owl:Class ;
    rdfs:label "activity" ;
    rdfs:subClassOf biolink:GeneOrGeneProductOrChemicalEntityAspectEnum,
        <https://w3id.org/biolink/vocab/GeneOrGeneProductOrChemicalEntityAspectEnum#activity_or_abundance> .

<https://w3id.org/biolink/vocab/GeneOrGeneProductOrChemicalEntityAspectEnum#acylation> a owl:Class ;
    rdfs:label "acylation" ;
    rdfs:subClassOf biolink:GeneOrGeneProductOrChemicalEntityAspectEnum,
        <https://w3id.org/biolink/vocab/GeneOrGeneProductOrChemicalEntityAspectEnum#molecular_modification> .

<https://w3id.org/biolink/vocab/GeneOrGeneProductOrChemicalEntityAspectEnum#adenyl_nucleotide_exchange> a owl:Class ;
    rdfs:label "adenyl_nucleotide_exchange" ;
    rdfs:subClassOf biolink:GeneOrGeneProductOrChemicalEntityAspectEnum,
        <https://w3id.org/biolink/vocab/GeneOrGeneProductOrChemicalEntityAspectEnum#molecular_interaction> .

<https://w3id.org/biolink/vocab/GeneOrGeneProductOrChemicalEntityAspectEnum#aggregation> a owl:Class ;
    rdfs:label "aggregation" ;
    rdfs:subClassOf biolink:GeneOrGeneProductOrChemicalEntityAspectEnum,
        linkml:PermissibleValue .

<https://w3id.org/biolink/vocab/GeneOrGeneProductOrChemicalEntityAspectEnum#alkylation> a owl:Class ;
    rdfs:label "alkylation" ;
    rdfs:subClassOf biolink:GeneOrGeneProductOrChemicalEntityAspectEnum,
        <https://w3id.org/biolink/vocab/GeneOrGeneProductOrChemicalEntityAspectEnum#molecular_modification> .

<https://w3id.org/biolink/vocab/GeneOrGeneProductOrChemicalEntityAspectEnum#amination> a owl:Class ;
    rdfs:label "amination" ;
    rdfs:subClassOf biolink:GeneOrGeneProductOrChemicalEntityAspectEnum,
        <https://w3id.org/biolink/vocab/GeneOrGeneProductOrChemicalEntityAspectEnum#molecular_modification> .

<https://w3id.org/biolink/vocab/GeneOrGeneProductOrChemicalEntityAspectEnum#carbamoylation> a owl:Class ;
    rdfs:label "carbamoylation" ;
    rdfs:subClassOf biolink:GeneOrGeneProductOrChemicalEntityAspectEnum,
        <https://w3id.org/biolink/vocab/GeneOrGeneProductOrChemicalEntityAspectEnum#molecular_modification> .

<https://w3id.org/biolink/vocab/GeneOrGeneProductOrChemicalEntityAspectEnum#carboxylation> a owl:Class ;
    rdfs:label "carboxylation" ;
    rdfs:subClassOf biolink:GeneOrGeneProductOrChemicalEntityAspectEnum,
        <https://w3id.org/biolink/vocab/GeneOrGeneProductOrChemicalEntityAspectEnum#molecular_modification> .

<https://w3id.org/biolink/vocab/GeneOrGeneProductOrChemicalEntityAspectEnum#degradation> a owl:Class ;
    rdfs:label "degradation" ;
    rdfs:subClassOf biolink:GeneOrGeneProductOrChemicalEntityAspectEnum,
        linkml:PermissibleValue .

<https://w3id.org/biolink/vocab/GeneOrGeneProductOrChemicalEntityAspectEnum#ethylation> a owl:Class ;
    rdfs:label "ethylation" ;
    rdfs:subClassOf biolink:GeneOrGeneProductOrChemicalEntityAspectEnum,
        <https://w3id.org/biolink/vocab/GeneOrGeneProductOrChemicalEntityAspectEnum#molecular_modification> .

<https://w3id.org/biolink/vocab/GeneOrGeneProductOrChemicalEntityAspectEnum#expression> a owl:Class ;
    rdfs:label "expression" ;
    rdfs:subClassOf biolink:GeneOrGeneProductOrChemicalEntityAspectEnum,
        <https://w3id.org/biolink/vocab/GeneOrGeneProductOrChemicalEntityAspectEnum#abundance> .

<https://w3id.org/biolink/vocab/GeneOrGeneProductOrChemicalEntityAspectEnum#farnesylation> a owl:Class ;
    rdfs:label "farnesylation" ;
    rdfs:subClassOf biolink:GeneOrGeneProductOrChemicalEntityAspectEnum,
        <https://w3id.org/biolink/vocab/GeneOrGeneProductOrChemicalEntityAspectEnum#molecular_modification> .

<https://w3id.org/biolink/vocab/GeneOrGeneProductOrChemicalEntityAspectEnum#folding> a owl:Class ;
    rdfs:label "folding" ;
    rdfs:subClassOf biolink:GeneOrGeneProductOrChemicalEntityAspectEnum,
        linkml:PermissibleValue .

<https://w3id.org/biolink/vocab/GeneOrGeneProductOrChemicalEntityAspectEnum#geranoylation> a owl:Class ;
    rdfs:label "geranoylation" ;
    rdfs:subClassOf biolink:GeneOrGeneProductOrChemicalEntityAspectEnum,
        <https://w3id.org/biolink/vocab/GeneOrGeneProductOrChemicalEntityAspectEnum#molecular_modification> .

<https://w3id.org/biolink/vocab/GeneOrGeneProductOrChemicalEntityAspectEnum#glucuronidation> a owl:Class ;
    rdfs:label "glucuronidation" ;
    rdfs:subClassOf biolink:GeneOrGeneProductOrChemicalEntityAspectEnum,
        <https://w3id.org/biolink/vocab/GeneOrGeneProductOrChemicalEntityAspectEnum#molecular_modification> .

<https://w3id.org/biolink/vocab/GeneOrGeneProductOrChemicalEntityAspectEnum#glutathionylation> a owl:Class ;
    rdfs:label "glutathionylation" ;
    rdfs:subClassOf biolink:GeneOrGeneProductOrChemicalEntityAspectEnum,
        <https://w3id.org/biolink/vocab/GeneOrGeneProductOrChemicalEntityAspectEnum#molecular_modification> .

<https://w3id.org/biolink/vocab/GeneOrGeneProductOrChemicalEntityAspectEnum#glycation> a owl:Class ;
    rdfs:label "glycation" ;
    rdfs:subClassOf biolink:GeneOrGeneProductOrChemicalEntityAspectEnum,
        <https://w3id.org/biolink/vocab/GeneOrGeneProductOrChemicalEntityAspectEnum#molecular_modification> .

<https://w3id.org/biolink/vocab/GeneOrGeneProductOrChemicalEntityAspectEnum#glycosylation> a owl:Class ;
    rdfs:label "glycosylation" ;
    rdfs:subClassOf biolink:GeneOrGeneProductOrChemicalEntityAspectEnum,
        <https://w3id.org/biolink/vocab/GeneOrGeneProductOrChemicalEntityAspectEnum#molecular_modification> .

<https://w3id.org/biolink/vocab/GeneOrGeneProductOrChemicalEntityAspectEnum#guanyl_nucleotide_exchange> a owl:Class ;
    rdfs:label "guanyl_nucleotide_exchange" ;
    rdfs:subClassOf biolink:GeneOrGeneProductOrChemicalEntityAspectEnum,
        <https://w3id.org/biolink/vocab/GeneOrGeneProductOrChemicalEntityAspectEnum#molecular_interaction> .

<https://w3id.org/biolink/vocab/GeneOrGeneProductOrChemicalEntityAspectEnum#hydrolysis> a owl:Class ;
    rdfs:label "hydrolysis" ;
    rdfs:subClassOf biolink:GeneOrGeneProductOrChemicalEntityAspectEnum,
        <https://w3id.org/biolink/vocab/GeneOrGeneProductOrChemicalEntityAspectEnum#cleavage> .

<https://w3id.org/biolink/vocab/GeneOrGeneProductOrChemicalEntityAspectEnum#hydroxylation> a owl:Class ;
    rdfs:label "hydroxylation" ;
    rdfs:subClassOf biolink:GeneOrGeneProductOrChemicalEntityAspectEnum,
        <https://w3id.org/biolink/vocab/GeneOrGeneProductOrChemicalEntityAspectEnum#molecular_modification> .

<https://w3id.org/biolink/vocab/GeneOrGeneProductOrChemicalEntityAspectEnum#interaction> a owl:Class ;
    rdfs:label "interaction" ;
    rdfs:subClassOf biolink:GeneOrGeneProductOrChemicalEntityAspectEnum,
        linkml:PermissibleValue .

<https://w3id.org/biolink/vocab/GeneOrGeneProductOrChemicalEntityAspectEnum#isomerization> a owl:Class ;
    rdfs:label "isomerization" ;
    rdfs:subClassOf biolink:GeneOrGeneProductOrChemicalEntityAspectEnum,
        linkml:PermissibleValue .

<https://w3id.org/biolink/vocab/GeneOrGeneProductOrChemicalEntityAspectEnum#lipidation> a owl:Class ;
    rdfs:label "lipidation" ;
    rdfs:subClassOf biolink:GeneOrGeneProductOrChemicalEntityAspectEnum,
        <https://w3id.org/biolink/vocab/GeneOrGeneProductOrChemicalEntityAspectEnum#molecular_modification> .

<https://w3id.org/biolink/vocab/GeneOrGeneProductOrChemicalEntityAspectEnum#localization> a owl:Class ;
    rdfs:label "localization" ;
    rdfs:subClassOf biolink:GeneOrGeneProductOrChemicalEntityAspectEnum,
        linkml:PermissibleValue .

<https://w3id.org/biolink/vocab/GeneOrGeneProductOrChemicalEntityAspectEnum#metabolic_processing> a owl:Class ;
    rdfs:label "metabolic_processing" ;
    rdfs:subClassOf biolink:GeneOrGeneProductOrChemicalEntityAspectEnum,
        linkml:PermissibleValue .

<https://w3id.org/biolink/vocab/GeneOrGeneProductOrChemicalEntityAspectEnum#methylation> a owl:Class ;
    rdfs:label "methylation" ;
    rdfs:subClassOf biolink:GeneOrGeneProductOrChemicalEntityAspectEnum,
        <https://w3id.org/biolink/vocab/GeneOrGeneProductOrChemicalEntityAspectEnum#molecular_modification> .

<https://w3id.org/biolink/vocab/GeneOrGeneProductOrChemicalEntityAspectEnum#mutation_rate> a owl:Class ;
    rdfs:label "mutation_rate" ;
    rdfs:subClassOf biolink:GeneOrGeneProductOrChemicalEntityAspectEnum,
        linkml:PermissibleValue .

<https://w3id.org/biolink/vocab/GeneOrGeneProductOrChemicalEntityAspectEnum#myristoylation> a owl:Class ;
    rdfs:label "myristoylation" ;
    rdfs:subClassOf biolink:GeneOrGeneProductOrChemicalEntityAspectEnum,
        <https://w3id.org/biolink/vocab/GeneOrGeneProductOrChemicalEntityAspectEnum#molecular_modification> .

<https://w3id.org/biolink/vocab/GeneOrGeneProductOrChemicalEntityAspectEnum#n_linked_glycosylation> a owl:Class ;
    rdfs:label "n_linked_glycosylation" ;
    rdfs:subClassOf biolink:GeneOrGeneProductOrChemicalEntityAspectEnum,
        <https://w3id.org/biolink/vocab/GeneOrGeneProductOrChemicalEntityAspectEnum#molecular_modification> .

<https://w3id.org/biolink/vocab/GeneOrGeneProductOrChemicalEntityAspectEnum#nitrosation> a owl:Class ;
    rdfs:label "nitrosation" ;
    rdfs:subClassOf biolink:GeneOrGeneProductOrChemicalEntityAspectEnum,
        <https://w3id.org/biolink/vocab/GeneOrGeneProductOrChemicalEntityAspectEnum#molecular_modification> .

<https://w3id.org/biolink/vocab/GeneOrGeneProductOrChemicalEntityAspectEnum#nucleotidylation> a owl:Class ;
    rdfs:label "nucleotidylation" ;
    rdfs:subClassOf biolink:GeneOrGeneProductOrChemicalEntityAspectEnum,
        <https://w3id.org/biolink/vocab/GeneOrGeneProductOrChemicalEntityAspectEnum#molecular_modification> .

<https://w3id.org/biolink/vocab/GeneOrGeneProductOrChemicalEntityAspectEnum#o_linked_glycosylation> a owl:Class ;
    rdfs:label "o_linked_glycosylation" ;
    rdfs:subClassOf biolink:GeneOrGeneProductOrChemicalEntityAspectEnum,
        <https://w3id.org/biolink/vocab/GeneOrGeneProductOrChemicalEntityAspectEnum#molecular_modification> .

<https://w3id.org/biolink/vocab/GeneOrGeneProductOrChemicalEntityAspectEnum#oxidation> a owl:Class ;
    rdfs:label "oxidation" ;
    rdfs:subClassOf biolink:GeneOrGeneProductOrChemicalEntityAspectEnum,
        <https://w3id.org/biolink/vocab/GeneOrGeneProductOrChemicalEntityAspectEnum#molecular_modification> .

<https://w3id.org/biolink/vocab/GeneOrGeneProductOrChemicalEntityAspectEnum#palmitoylation> a owl:Class ;
    rdfs:label "palmitoylation" ;
    rdfs:subClassOf biolink:GeneOrGeneProductOrChemicalEntityAspectEnum,
        <https://w3id.org/biolink/vocab/GeneOrGeneProductOrChemicalEntityAspectEnum#molecular_modification> .

<https://w3id.org/biolink/vocab/GeneOrGeneProductOrChemicalEntityAspectEnum#phosphorylation> a owl:Class ;
    rdfs:label "phosphorylation" ;
    rdfs:subClassOf biolink:GeneOrGeneProductOrChemicalEntityAspectEnum,
        <https://w3id.org/biolink/vocab/GeneOrGeneProductOrChemicalEntityAspectEnum#molecular_modification> .

<https://w3id.org/biolink/vocab/GeneOrGeneProductOrChemicalEntityAspectEnum#prenylation> a owl:Class ;
    rdfs:label "prenylation" ;
    rdfs:subClassOf biolink:GeneOrGeneProductOrChemicalEntityAspectEnum,
        <https://w3id.org/biolink/vocab/GeneOrGeneProductOrChemicalEntityAspectEnum#molecular_modification> .

<https://w3id.org/biolink/vocab/GeneOrGeneProductOrChemicalEntityAspectEnum#reduction> a owl:Class ;
    rdfs:label "reduction" ;
    rdfs:subClassOf biolink:GeneOrGeneProductOrChemicalEntityAspectEnum,
        <https://w3id.org/biolink/vocab/GeneOrGeneProductOrChemicalEntityAspectEnum#molecular_modification> .

<https://w3id.org/biolink/vocab/GeneOrGeneProductOrChemicalEntityAspectEnum#release> a owl:Class ;
    rdfs:label "release" ;
    rdfs:subClassOf biolink:GeneOrGeneProductOrChemicalEntityAspectEnum,
        linkml:PermissibleValue .

<https://w3id.org/biolink/vocab/GeneOrGeneProductOrChemicalEntityAspectEnum#ribosylation> a owl:Class ;
    rdfs:label "ribosylation" ;
    rdfs:subClassOf biolink:GeneOrGeneProductOrChemicalEntityAspectEnum,
        <https://w3id.org/biolink/vocab/GeneOrGeneProductOrChemicalEntityAspectEnum#molecular_modification> .

<https://w3id.org/biolink/vocab/GeneOrGeneProductOrChemicalEntityAspectEnum#secretion> a owl:Class ;
    rdfs:label "secretion" ;
    rdfs:subClassOf biolink:GeneOrGeneProductOrChemicalEntityAspectEnum,
        <https://w3id.org/biolink/vocab/GeneOrGeneProductOrChemicalEntityAspectEnum#transport> .

<https://w3id.org/biolink/vocab/GeneOrGeneProductOrChemicalEntityAspectEnum#splicing> a owl:Class ;
    rdfs:label "splicing" ;
    rdfs:subClassOf biolink:GeneOrGeneProductOrChemicalEntityAspectEnum,
        linkml:PermissibleValue .

<https://w3id.org/biolink/vocab/GeneOrGeneProductOrChemicalEntityAspectEnum#stability> a owl:Class ;
    rdfs:label "stability" ;
    rdfs:subClassOf biolink:GeneOrGeneProductOrChemicalEntityAspectEnum,
        linkml:PermissibleValue .

<https://w3id.org/biolink/vocab/GeneOrGeneProductOrChemicalEntityAspectEnum#sulfation> a owl:Class ;
    rdfs:label "sulfation" ;
    rdfs:subClassOf biolink:GeneOrGeneProductOrChemicalEntityAspectEnum,
        <https://w3id.org/biolink/vocab/GeneOrGeneProductOrChemicalEntityAspectEnum#molecular_modification> .

<https://w3id.org/biolink/vocab/GeneOrGeneProductOrChemicalEntityAspectEnum#sumoylation> a owl:Class ;
    rdfs:label "sumoylation" ;
    rdfs:subClassOf biolink:GeneOrGeneProductOrChemicalEntityAspectEnum,
        <https://w3id.org/biolink/vocab/GeneOrGeneProductOrChemicalEntityAspectEnum#molecular_modification> .

<https://w3id.org/biolink/vocab/GeneOrGeneProductOrChemicalEntityAspectEnum#synthesis> a owl:Class ;
    rdfs:label "synthesis" ;
    rdfs:subClassOf biolink:GeneOrGeneProductOrChemicalEntityAspectEnum,
        <https://w3id.org/biolink/vocab/GeneOrGeneProductOrChemicalEntityAspectEnum#abundance> .

<https://w3id.org/biolink/vocab/GeneOrGeneProductOrChemicalEntityAspectEnum#ubiquitination> a owl:Class ;
    rdfs:label "ubiquitination" ;
    rdfs:subClassOf biolink:GeneOrGeneProductOrChemicalEntityAspectEnum,
        <https://w3id.org/biolink/vocab/GeneOrGeneProductOrChemicalEntityAspectEnum#molecular_modification> .

<https://w3id.org/biolink/vocab/GeneOrGeneProductOrChemicalEntityAspectEnum#uptake> a owl:Class ;
    rdfs:label "uptake" ;
    rdfs:subClassOf biolink:GeneOrGeneProductOrChemicalEntityAspectEnum,
        <https://w3id.org/biolink/vocab/GeneOrGeneProductOrChemicalEntityAspectEnum#transport> .

<https://w3id.org/biolink/vocab/GeneOrGeneProductOrChemicalPartQualifierEnum#3_prime_utr> a owl:Class ;
    rdfs:label "3_prime_utr" ;
    rdfs:subClassOf biolink:GeneOrGeneProductOrChemicalPartQualifierEnum,
        linkml:PermissibleValue .

<https://w3id.org/biolink/vocab/GeneOrGeneProductOrChemicalPartQualifierEnum#5_prime_utr> a owl:Class ;
    rdfs:label "5_prime_utr" ;
    rdfs:subClassOf biolink:GeneOrGeneProductOrChemicalPartQualifierEnum,
        linkml:PermissibleValue .

<https://w3id.org/biolink/vocab/GeneOrGeneProductOrChemicalPartQualifierEnum#enhancer> a owl:Class ;
    rdfs:label "enhancer" ;
    rdfs:subClassOf biolink:GeneOrGeneProductOrChemicalPartQualifierEnum,
        linkml:PermissibleValue .

<https://w3id.org/biolink/vocab/GeneOrGeneProductOrChemicalPartQualifierEnum#exon> a owl:Class ;
    rdfs:label "exon" ;
    rdfs:subClassOf biolink:GeneOrGeneProductOrChemicalPartQualifierEnum,
        linkml:PermissibleValue .

<https://w3id.org/biolink/vocab/GeneOrGeneProductOrChemicalPartQualifierEnum#intron> a owl:Class ;
    rdfs:label "intron" ;
    rdfs:subClassOf biolink:GeneOrGeneProductOrChemicalPartQualifierEnum,
        linkml:PermissibleValue .

<https://w3id.org/biolink/vocab/GeneOrGeneProductOrChemicalPartQualifierEnum#polya_tail> a owl:Class ;
    rdfs:label "polya_tail" ;
    rdfs:subClassOf biolink:GeneOrGeneProductOrChemicalPartQualifierEnum,
        linkml:PermissibleValue .

<https://w3id.org/biolink/vocab/GeneOrGeneProductOrChemicalPartQualifierEnum#promoter> a owl:Class ;
    rdfs:label "promoter" ;
    rdfs:subClassOf biolink:GeneOrGeneProductOrChemicalPartQualifierEnum,
        linkml:PermissibleValue .

biolink:GeneOrGeneProductOrGeneFamilyToAnatomicalEntityAssociation a owl:Class ;
    rdfs:label "gene or gene product or gene family to anatomical entity association" ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:subject ],
        [ a owl:Restriction ;
            owl:allValuesFrom biolink:AnatomicalEntity ;
            owl:onProperty biolink:object ],
        [ a owl:Restriction ;
            owl:minCardinality 1 ;
            owl:onProperty biolink:subject ],
        [ a owl:Restriction ;
            owl:allValuesFrom biolink:GeneOrGeneProductOrGeneFamily ;
            owl:onProperty biolink:subject ],
        [ a owl:Restriction ;
            owl:minCardinality 1 ;
            owl:onProperty biolink:object ],
        [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:object ],
        biolink:Association ;
    skos:definition "An association between a gene or gene product or gene family and an anatomical entity." ;
    skos:inScheme biolink: .

biolink:GeneOrGeneProductOrGeneFamilyToBiologicalProcessOrActivityAssociation a owl:Class ;
    rdfs:label "gene or gene product or gene family to biological process or activity association" ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:allValuesFrom xsd:string ;
            owl:onProperty biolink:predicate ],
        [ a owl:Restriction ;
            owl:minCardinality 1 ;
            owl:onProperty biolink:subject ],
        [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:subject ],
        [ a owl:Restriction ;
            owl:minCardinality 1 ;
            owl:onProperty biolink:predicate ],
        [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:predicate ],
        [ a owl:Restriction ;
            owl:minCardinality 1 ;
            owl:onProperty biolink:object ],
        [ a owl:Restriction ;
            owl:allValuesFrom biolink:GeneOrGeneProductOrGeneFamily ;
            owl:onProperty biolink:subject ],
        [ a owl:Restriction ;
            owl:allValuesFrom biolink:BiologicalProcessOrActivity ;
            owl:onProperty biolink:object ],
        [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:object ],
        biolink:Association ;
    skos:definition "Relationship between a gene or gene product or gene family to a specified biological process or activity (e.g. molecular activity, biological process or pathway)." ;
    skos:inScheme biolink: .

biolink:GeneRegulatesGeneAssociation a owl:Class ;
    rdfs:label "gene regulates gene association" ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:predicate ],
        [ a owl:Restriction ;
            owl:minCardinality 0 ;
            owl:onProperty biolink:causal_mechanism_qualifier ],
        [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:species_context_qualifier ],
        [ a owl:Restriction ;
            owl:minCardinality 0 ;
            owl:onProperty biolink:species_context_qualifier ],
        [ a owl:Restriction ;
            owl:allValuesFrom xsd:anyURI ;
            owl:onProperty biolink:qualified_predicate ],
        [ a owl:Restriction ;
            owl:minCardinality 1 ;
            owl:onProperty biolink:subject ],
        [ a owl:Restriction ;
            owl:minCardinality 1 ;
            owl:onProperty biolink:object ],
        [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:object_direction_qualifier ],
        [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:object_aspect_qualifier ],
        [ a owl:Restriction ;
            owl:allValuesFrom biolink:CausalMechanismQualifierEnum ;
            owl:onProperty biolink:causal_mechanism_qualifier ],
        [ a owl:Restriction ;
            owl:minCardinality 1 ;
            owl:onProperty biolink:object_aspect_qualifier ],
        [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:qualified_predicate ],
        [ a owl:Restriction ;
            owl:minCardinality 1 ;
            owl:onProperty biolink:predicate ],
        [ a owl:Restriction ;
            owl:allValuesFrom biolink:OrganismTaxon ;
            owl:onProperty biolink:species_context_qualifier ],
        [ a owl:Restriction ;
            owl:allValuesFrom biolink:DirectionQualifierEnum ;
            owl:onProperty biolink:object_direction_qualifier ],
        [ a owl:Restriction ;
            owl:allValuesFrom xsd:string ;
            owl:onProperty biolink:predicate ],
        [ a owl:Restriction ;
            owl:minCardinality 1 ;
            owl:onProperty biolink:object_direction_qualifier ],
        [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:subject ],
        [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:causal_mechanism_qualifier ],
        [ a owl:Restriction ;
            owl:allValuesFrom biolink:ChemicalEntityOrGeneOrGeneProduct ;
            owl:onProperty biolink:object ],
        [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:object ],
        [ a owl:Restriction ;
            owl:allValuesFrom biolink:GeneOrGeneProductOrChemicalEntityAspectEnum ;
            owl:onProperty biolink:object_aspect_qualifier ],
        [ a owl:Restriction ;
            owl:allValuesFrom biolink:ChemicalEntityOrGeneOrGeneProduct ;
            owl:onProperty biolink:subject ],
        [ a owl:Restriction ;
            owl:minCardinality 1 ;
            owl:onProperty biolink:qualified_predicate ],
        biolink:Association ;
    skos:definition "Describes a regulatory relationship between two genes or gene products." ;
    skos:inScheme biolink: .

<https://w3id.org/biolink/vocab/GeneToDiseasePredicateEnum#biolink%3Aaffects> a owl:Class ;
    rdfs:label "biolink:affects" ;
    rdfs:subClassOf biolink:GeneToDiseasePredicateEnum,
        linkml:PermissibleValue .

<https://w3id.org/biolink/vocab/GeneToDiseasePredicateEnum#biolink%3Aassociated_with> a owl:Class ;
    rdfs:label "biolink:associated_with" ;
    rdfs:subClassOf biolink:GeneToDiseasePredicateEnum,
        linkml:PermissibleValue .

<https://w3id.org/biolink/vocab/GeneToDiseasePredicateEnum#biolink%3Acontributes_to> a owl:Class ;
    rdfs:label "biolink:contributes_to" ;
    rdfs:subClassOf biolink:GeneToDiseasePredicateEnum,
        linkml:PermissibleValue .

biolink:GeneToExpressionSiteAssociation a owl:Class ;
    rdfs:label "gene to expression site association" ;
    rdfs:seeAlso <https://github.com/monarch-initiative/ingest-artifacts/tree/master/sources/BGee> ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:allValuesFrom biolink:GeneOrGeneProduct ;
            owl:onProperty biolink:subject ],
        [ a owl:Restriction ;
            owl:allValuesFrom biolink:OntologyClass ;
            owl:onProperty biolink:quantifier_qualifier ],
        [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:object ],
        [ a owl:Restriction ;
            owl:minCardinality 0 ;
            owl:onProperty biolink:quantifier_qualifier ],
        [ a owl:Restriction ;
            owl:minCardinality 1 ;
            owl:onProperty biolink:predicate ],
        [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:stage_qualifier ],
        [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:quantifier_qualifier ],
        [ a owl:Restriction ;
            owl:allValuesFrom biolink:AnatomicalEntity ;
            owl:onProperty biolink:object ],
        [ a owl:Restriction ;
            owl:minCardinality 1 ;
            owl:onProperty biolink:subject ],
        [ a owl:Restriction ;
            owl:minCardinality 1 ;
            owl:onProperty biolink:object ],
        [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:predicate ],
        [ a owl:Restriction ;
            owl:minCardinality 0 ;
            owl:onProperty biolink:stage_qualifier ],
        [ a owl:Restriction ;
            owl:allValuesFrom xsd:string ;
            owl:onProperty biolink:predicate ],
        [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:object_specialization_qualifier ],
        [ a owl:Restriction ;
            owl:allValuesFrom biolink:LifeStage ;
            owl:onProperty biolink:stage_qualifier ],
        [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:subject ],
        [ a owl:Restriction ;
            owl:minCardinality 0 ;
            owl:onProperty biolink:object_specialization_qualifier ],
        [ a owl:Restriction ;
            owl:allValuesFrom xsd:anyURI ;
            owl:onProperty biolink:object_specialization_qualifier ],
        biolink:Association ;
    skos:definition "An association between a gene and a gene expression site, possibly qualified by stage/timing info." ;
    skos:editorialNote "TBD: introduce subclasses for distinction between wild-type and experimental conditions?" ;
    skos:inScheme biolink: .

biolink:GeneToGeneCoexpressionAssociation a owl:Class ;
    rdfs:label "gene to gene coexpression association" ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:onProperty linkml:mixins ;
            owl:someValuesFrom biolink:GeneExpressionMixin ],
        [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:predicate ],
        [ a owl:Restriction ;
            owl:allValuesFrom xsd:string ;
            owl:onProperty biolink:predicate ],
        [ a owl:Restriction ;
            owl:minCardinality 1 ;
            owl:onProperty biolink:predicate ],
        biolink:GeneToGeneAssociation ;
    skos:definition "Indicates that two genes are co-expressed, generally under the same conditions." ;
    skos:inScheme biolink: .

biolink:GeneToGeneFamilyAssociation a owl:Class ;
    rdfs:label "gene to gene family association" ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:minCardinality 1 ;
            owl:onProperty biolink:object ],
        [ a owl:Restriction ;
            owl:minCardinality 1 ;
            owl:onProperty biolink:predicate ],
        [ a owl:Restriction ;
            owl:allValuesFrom biolink:GeneFamily ;
            owl:onProperty biolink:object ],
        [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:predicate ],
        [ a owl:Restriction ;
            owl:minCardinality 1 ;
            owl:onProperty biolink:subject ],
        [ a owl:Restriction ;
            owl:allValuesFrom biolink:Gene ;
            owl:onProperty biolink:subject ],
        [ a owl:Restriction ;
            owl:allValuesFrom xsd:string ;
            owl:onProperty biolink:predicate ],
        [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:object ],
        [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:subject ],
        biolink:Association ;
    skos:definition "Set membership of a gene in a family of genes related by common evolutionary ancestry usually inferred by sequence comparisons. The genes in a given family generally share common sequence motifs which generally map onto shared gene product structure-function relationships." ;
    skos:inScheme biolink: .

biolink:GeneToGeneHomologyAssociation a owl:Class ;
    rdfs:label "gene to gene homology association" ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:allValuesFrom xsd:string ;
            owl:onProperty biolink:predicate ],
        [ a owl:Restriction ;
            owl:allValuesFrom biolink:GeneOrGeneProduct ;
            owl:onProperty biolink:object ],
        [ a owl:Restriction ;
            owl:minCardinality 1 ;
            owl:onProperty biolink:object ],
        [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:predicate ],
        [ a owl:Restriction ;
            owl:allValuesFrom biolink:GeneOrGeneProduct ;
            owl:onProperty biolink:subject ],
        [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:object ],
        [ a owl:Restriction ;
            owl:minCardinality 1 ;
            owl:onProperty biolink:predicate ],
        [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:subject ],
        [ a owl:Restriction ;
            owl:minCardinality 1 ;
            owl:onProperty biolink:subject ],
        biolink:GeneToGeneAssociation ;
    skos:definition "A homology association between two genes. May be orthology (in which case the species of subject and object should differ) or paralogy (in which case the species may be the same)" ;
    skos:inScheme biolink: .

biolink:GeneToGeneProductRelationship a owl:Class ;
    rdfs:label "gene to gene product relationship" ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:allValuesFrom xsd:string ;
            owl:onProperty biolink:predicate ],
        [ a owl:Restriction ;
            owl:minCardinality 1 ;
            owl:onProperty biolink:object ],
        [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:predicate ],
        [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:object ],
        [ a owl:Restriction ;
            owl:minCardinality 1 ;
            owl:onProperty biolink:predicate ],
        [ a owl:Restriction ;
            owl:allValuesFrom biolink:GeneProductMixin ;
            owl:onProperty biolink:object ],
        [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:subject ],
        [ a owl:Restriction ;
            owl:minCardinality 1 ;
            owl:onProperty biolink:subject ],
        [ a owl:Restriction ;
            owl:allValuesFrom biolink:Gene ;
            owl:onProperty biolink:subject ],
        biolink:SequenceFeatureRelationship ;
    skos:definition "A gene is transcribed and potentially translated to a gene product" ;
    skos:inScheme biolink: .

biolink:GeneToGoTermAssociation a owl:Class ;
    rdfs:label "gene to go term association" ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:subject ],
        [ a owl:Restriction ;
            owl:allValuesFrom biolink:Gene ;
            owl:onProperty biolink:subject ],
        [ a owl:Restriction ;
            owl:allValuesFrom biolink:OntologyClass ;
            owl:onProperty biolink:object ],
        [ a owl:Restriction ;
            owl:minCardinality 1 ;
            owl:onProperty biolink:object ],
        [ a owl:Restriction ;
            owl:minCardinality 1 ;
            owl:onProperty biolink:subject ],
        [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:object ],
        biolink:FunctionalAssociation ;
    skos:altLabel "functional association" ;
    skos:definition "A functional association between a gene (or gene product or macromolecular complex) and a Gene Ontology (GO) term describing the molecular function, biological process, or cellular component in which it participates." ;
    skos:exactMatch WBVocab:Gene-GO-Association ;
    skos:inScheme biolink: .

biolink:GeneToPathwayAssociation a owl:Class ;
    rdfs:label "gene to pathway association" ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:minCardinality 1 ;
            owl:onProperty biolink:subject ],
        [ a owl:Restriction ;
            owl:allValuesFrom biolink:Pathway ;
            owl:onProperty biolink:object ],
        [ a owl:Restriction ;
            owl:minCardinality 1 ;
            owl:onProperty biolink:object ],
        [ a owl:Restriction ;
            owl:allValuesFrom biolink:GeneOrGeneProduct ;
            owl:onProperty biolink:subject ],
        [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:subject ],
        [ a owl:Restriction ;
            owl:onProperty linkml:mixins ;
            owl:someValuesFrom biolink:GeneToEntityAssociationMixin ],
        [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:object ],
        biolink:Association ;
    skos:definition "An interaction between a gene or gene product and a biological process or pathway." ;
    skos:inScheme biolink: .

biolink:GeneToPhenotypicFeatureAssociation a owl:Class ;
    rdfs:label "gene to phenotypic feature association" ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:minCardinality 0 ;
            owl:onProperty biolink:subject_aspect_qualifier ],
        [ a owl:Restriction ;
            owl:allValuesFrom biolink:GeneOrGeneProduct ;
            owl:onProperty biolink:subject ],
        [ a owl:Restriction ;
            owl:minCardinality 0 ;
            owl:onProperty biolink:subject_form_or_variant_qualifier ],
        [ a owl:Restriction ;
            owl:minCardinality 0 ;
            owl:onProperty biolink:allelic_requirement ],
        [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:predicate ],
        [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:subject ],
        [ a owl:Restriction ;
            owl:allValuesFrom biolink:ChemicalOrGeneOrGeneProductFormOrVariantEnum ;
            owl:onProperty biolink:subject_form_or_variant_qualifier ],
        [ a owl:Restriction ;
            owl:minCardinality 1 ;
            owl:onProperty biolink:object ],
        [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:subject_form_or_variant_qualifier ],
        [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:object_direction_qualifier ],
        [ a owl:Restriction ;
            owl:onProperty linkml:mixins ;
            owl:someValuesFrom biolink:EntityToPhenotypicFeatureAssociationMixin ],
        [ a owl:Restriction ;
            owl:minCardinality 0 ;
            owl:onProperty biolink:object_direction_qualifier ],
        [ a owl:Restriction ;
            owl:allValuesFrom biolink:GeneToPhenotypicFeaturePredicateEnum ;
            owl:onProperty biolink:predicate ],
        [ a owl:Restriction ;
            owl:allValuesFrom biolink:GeneOrGeneProductOrChemicalEntityAspectEnum ;
            owl:onProperty biolink:subject_aspect_qualifier ],
        [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:allelic_requirement ],
        [ a owl:Restriction ;
            owl:minCardinality 1 ;
            owl:onProperty biolink:subject ],
        [ a owl:Restriction ;
            owl:allValuesFrom [ a rdfs:Datatype ;
                    owl:intersectionOf ( xsd:string [ a rdfs:Datatype ;
                                owl:onDatatype xsd:string ;
                                owl:withRestrictions ( [ xsd:pattern "^HP:\\d{7}$" ] ) ] ) ] ;
            owl:onProperty biolink:allelic_requirement ],
        [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:subject_aspect_qualifier ],
        [ a owl:Restriction ;
            owl:onProperty linkml:mixins ;
            owl:someValuesFrom biolink:GeneToEntityAssociationMixin ],
        [ a owl:Restriction ;
            owl:allValuesFrom biolink:PhenotypicFeature ;
            owl:onProperty biolink:object ],
        [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:object ],
        [ a owl:Restriction ;
            owl:allValuesFrom biolink:DirectionQualifierEnum ;
            owl:onProperty biolink:object_direction_qualifier ],
        [ a owl:Restriction ;
            owl:minCardinality 1 ;
            owl:onProperty biolink:predicate ],
        biolink:Association ;
    skos:definition "An association between a gene or gene product and a phenotypic feature, where variation in the gene is correlated with the phenotypic feature." ;
    skos:exactMatch WBVocab:Gene-Phenotype-Association ;
    skos:inScheme biolink: ;
    skos:narrowMatch SIO:000983,
        dcid:DiseaseGeneAssociation ;
    skos:note "NCIT:R176 refers to the inverse relationship",
        "for use in describing the affect that the loss of function of a gene can have on exacerbating or ameliorating a symptom/phenotype",
        "if the relationship of the statement using this predicate is statistical in nature, please use `associated with likelihood` or one of its children." .

<https://w3id.org/biolink/vocab/GeneToPhenotypicFeaturePredicateEnum#biolink%3Aassociated_with> a owl:Class ;
    rdfs:label "biolink:associated_with" ;
    rdfs:subClassOf biolink:GeneToPhenotypicFeaturePredicateEnum,
        linkml:PermissibleValue .

<https://w3id.org/biolink/vocab/GeneToPhenotypicFeaturePredicateEnum#biolink%3Acauses> a owl:Class ;
    rdfs:label "biolink:causes" ;
    rdfs:subClassOf biolink:GeneToPhenotypicFeaturePredicateEnum,
        linkml:PermissibleValue .

<https://w3id.org/biolink/vocab/GeneToPhenotypicFeaturePredicateEnum#biolink%3Acontributes_to> a owl:Class ;
    rdfs:label "biolink:contributes_to" ;
    rdfs:subClassOf biolink:GeneToPhenotypicFeaturePredicateEnum,
        linkml:PermissibleValue .

<https://w3id.org/biolink/vocab/GeneToPhenotypicFeaturePredicateEnum#biolink%3Ahas_phenotype> a owl:Class ;
    rdfs:label "biolink:has_phenotype" ;
    rdfs:subClassOf biolink:GeneToPhenotypicFeaturePredicateEnum,
        linkml:PermissibleValue .

biolink:GenomicBackgroundExposure a owl:Class ;
    rdfs:label "genomic background exposure" ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:onProperty linkml:mixins ;
            owl:someValuesFrom biolink:OntologyClass ],
        [ a owl:Restriction ;
            owl:onProperty linkml:mixins ;
            owl:someValuesFrom biolink:ThingWithTaxon ],
        [ a owl:Restriction ;
            owl:onProperty linkml:mixins ;
            owl:someValuesFrom biolink:GeneGroupingMixin ],
        [ a owl:Restriction ;
            owl:onProperty linkml:mixins ;
            owl:someValuesFrom biolink:GenomicEntity ],
        [ a owl:Restriction ;
            owl:onProperty linkml:mixins ;
            owl:someValuesFrom biolink:PhysicalEssence ],
        biolink:ExposureEvent ;
    skos:definition "A genomic background exposure is where an individual's specific genomic background of genes, sequence variants or other pre-existing genomic conditions constitute a kind of 'exposure' to the organism, leading to or influencing an outcome." ;
    skos:inScheme biolink: .

biolink:GenotypeAsAModelOfDiseaseAssociation a owl:Class ;
    rdfs:label "genotype as a model of disease association" ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:onProperty linkml:mixins ;
            owl:someValuesFrom biolink:ModelToDiseaseAssociationMixin ],
        [ a owl:Restriction ;
            owl:minCardinality 1 ;
            owl:onProperty biolink:subject ],
        [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:subject ],
        [ a owl:Restriction ;
            owl:allValuesFrom biolink:Genotype ;
            owl:onProperty biolink:subject ],
        [ a owl:Restriction ;
            owl:onProperty linkml:mixins ;
            owl:someValuesFrom biolink:EntityToDiseaseAssociationMixin ],
        biolink:GenotypeToDiseaseAssociation ;
    skos:definition "An association in which a genotype serves as a model of a disease, recapitulating features relevant for studying the disease outside of a patient who carries it." ;
    skos:inScheme biolink: .

biolink:GenotypeToGeneAssociation a owl:Class ;
    rdfs:label "genotype to gene association" ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:minCardinality 1 ;
            owl:onProperty biolink:predicate ],
        [ a owl:Restriction ;
            owl:minCardinality 1 ;
            owl:onProperty biolink:object ],
        [ a owl:Restriction ;
            owl:allValuesFrom xsd:string ;
            owl:onProperty biolink:predicate ],
        [ a owl:Restriction ;
            owl:minCardinality 1 ;
            owl:onProperty biolink:subject ],
        [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:subject ],
        [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:predicate ],
        [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:object ],
        [ a owl:Restriction ;
            owl:allValuesFrom biolink:Genotype ;
            owl:onProperty biolink:subject ],
        [ a owl:Restriction ;
            owl:allValuesFrom biolink:Gene ;
            owl:onProperty biolink:object ],
        biolink:Association ;
    skos:definition "Any association between a genotype and a gene. The genotype have have multiple variants in that gene or a single one. There is no assumption of cardinality" ;
    skos:inScheme biolink: .

biolink:GenotypeToGenotypePartAssociation a owl:Class ;
    rdfs:label "genotype to genotype part association" ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:minCardinality 1 ;
            owl:onProperty biolink:predicate ],
        [ a owl:Restriction ;
            owl:minCardinality 1 ;
            owl:onProperty biolink:object ],
        [ a owl:Restriction ;
            owl:allValuesFrom biolink:Genotype ;
            owl:onProperty biolink:subject ],
        [ a owl:Restriction ;
            owl:minCardinality 1 ;
            owl:onProperty biolink:subject ],
        [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:subject ],
        [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:predicate ],
        [ a owl:Restriction ;
            owl:allValuesFrom xsd:string ;
            owl:onProperty biolink:predicate ],
        [ a owl:Restriction ;
            owl:allValuesFrom biolink:Genotype ;
            owl:onProperty biolink:object ],
        [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:object ],
        biolink:Association ;
    skos:definition "Any association between one genotype and a genotypic entity that is a sub-component of it" ;
    skos:inScheme biolink: .

biolink:GenotypeToPhenotypicFeatureAssociation a owl:Class ;
    rdfs:label "genotype to phenotypic feature association" ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:subject ],
        [ a owl:Restriction ;
            owl:onProperty linkml:mixins ;
            owl:someValuesFrom biolink:EntityToPhenotypicFeatureAssociationMixin ],
        [ a owl:Restriction ;
            owl:allValuesFrom biolink:Genotype ;
            owl:onProperty biolink:subject ],
        [ a owl:Restriction ;
            owl:onProperty linkml:mixins ;
            owl:someValuesFrom biolink:GenotypeToEntityAssociationMixin ],
        [ a owl:Restriction ;
            owl:minCardinality 1 ;
            owl:onProperty biolink:predicate ],
        [ a owl:Restriction ;
            owl:allValuesFrom xsd:string ;
            owl:onProperty biolink:predicate ],
        [ a owl:Restriction ;
            owl:minCardinality 1 ;
            owl:onProperty biolink:subject ],
        [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:predicate ],
        biolink:Association ;
    skos:definition "Any association between one genotype and a phenotypic feature, where having the genotype confers the phenotype, either in isolation or through environment" ;
    skos:inScheme biolink: .

biolink:GenotypeToVariantAssociation a owl:Class ;
    rdfs:label "genotype to variant association" ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:object ],
        [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:subject ],
        [ a owl:Restriction ;
            owl:minCardinality 1 ;
            owl:onProperty biolink:subject ],
        [ a owl:Restriction ;
            owl:allValuesFrom biolink:Genotype ;
            owl:onProperty biolink:subject ],
        [ a owl:Restriction ;
            owl:allValuesFrom biolink:SequenceVariant ;
            owl:onProperty biolink:object ],
        [ a owl:Restriction ;
            owl:minCardinality 1 ;
            owl:onProperty biolink:object ],
        [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:predicate ],
        [ a owl:Restriction ;
            owl:minCardinality 1 ;
            owl:onProperty biolink:predicate ],
        [ a owl:Restriction ;
            owl:allValuesFrom xsd:string ;
            owl:onProperty biolink:predicate ],
        biolink:Association ;
    skos:definition "Any association between a genotype and a sequence variant." ;
    skos:inScheme biolink: .

biolink:GenotypicSex a owl:Class ;
    rdfs:label "genotypic sex" ;
    rdfs:subClassOf biolink:BiologicalSex ;
    skos:definition "An attribute corresponding to the genotypic sex of the individual, based upon genotypic composition of sex chromosomes." ;
    skos:exactMatch <http://purl.obolibrary.org/obo/PATO_0020000> ;
    skos:inScheme biolink: .

biolink:GeographicExposure a owl:Class ;
    rdfs:label "geographic exposure" ;
    rdfs:subClassOf biolink:EnvironmentalExposure ;
    skos:closeMatch dcid:GeologicalEvent ;
    skos:definition "A geographic exposure is a factor relating to geographic proximity to some impactful entity." ;
    skos:inScheme biolink: ;
    skos:narrowMatch dcid:IceStoremEvent,
        dcid:LakeEffectSnowEvent,
        dcid:LandslideEvent,
        dcid:MarineDenseFogEvent,
        dcid:MarineLighteningEvent,
        dcid:MarineStrongWindEvent,
        dcid:MarineThunderstormWindEvent,
        dcid:StormEvent,
        dcid:StormSurgeTideEvent,
        dcid:StrongWindEvent,
        dcid:ThunderstormWindEvent,
        dcid:TornadoEvent,
        dcid:TropicalDepressionEvent,
        dcid:WinterStoremEvent .

biolink:GeographicLocationAtTime a owl:Class ;
    rdfs:label "geographic location at time" ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:allValuesFrom xsd:string ;
            owl:onProperty biolink:timepoint ],
        [ a owl:Restriction ;
            owl:minCardinality 0 ;
            owl:onProperty biolink:timepoint ],
        [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:timepoint ],
        biolink:GeographicLocation ;
    skos:definition "a location that can be described in lat/long coordinates, for a particular time" ;
    skos:inScheme biolink: .

biolink:GrossAnatomicalStructure a owl:Class ;
    rdfs:label "gross anatomical structure" ;
    rdfs:subClassOf biolink:AnatomicalEntity ;
    skos:altLabel "organ",
        "tissue" ;
    skos:definition "An anatomical structure that has more than one cell as a part." ;
    skos:exactMatch <http://purl.obolibrary.org/obo/UBERON_0010000>,
        WIKIDATA:Q4936952 ;
    skos:inScheme biolink: ;
    skos:narrowMatch STY:T018,
        STY:T023,
        STY:T024 .

biolink:Hospitalization a owl:Class ;
    rdfs:label "hospitalization" ;
    rdfs:subClassOf biolink:ClinicalIntervention ;
    skos:definition "The admission and care of a patient in a hospital for observation, diagnosis, or treatment." ;
    skos:exactMatch SNOMEDCT:32485007,
        WIKIDATA:Q3140971 ;
    skos:inScheme biolink: .

biolink:Human a owl:Class ;
    rdfs:label "human" ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:onProperty linkml:mixins ;
            owl:someValuesFrom biolink:SubjectOfInvestigation ],
        biolink:Mammal ;
    skos:exactMatch STY:T016,
        <http://purl.obolibrary.org/obo/NCBITaxon_9606>,
        <http://purl.obolibrary.org/obo/NCIT_C14225>,
        SIO:000485 ;
    skos:inScheme biolink: .

biolink:InformationContentEntityToNamedThingAssociation a owl:Class ;
    rdfs:label "information content entity to named thing association" ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:allValuesFrom owl:Thing ;
            owl:onProperty biolink:subject ],
        [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:predicate ],
        [ a owl:Restriction ;
            owl:allValuesFrom biolink:NamedThing ;
            owl:onProperty biolink:object ],
        [ a owl:Restriction ;
            owl:minCardinality 1 ;
            owl:onProperty biolink:predicate ],
        [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:object ],
        [ a owl:Restriction ;
            owl:allValuesFrom xsd:string ;
            owl:onProperty biolink:predicate ],
        [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:subject ],
        [ a owl:Restriction ;
            owl:minCardinality 1 ;
            owl:onProperty biolink:subject ],
        [ a owl:Restriction ;
            owl:minCardinality 1 ;
            owl:onProperty biolink:object ],
        biolink:Association ;
    skos:definition "association between a named thing and a information content entity where the specific context of the relationship between that named thing and the publication is unknown. For example, model organisms databases often capture the knowledge that a gene is found in a journal article, but not specifically the context in which that gene was documented in the article. In these cases, this association with the accompanying predicate 'mentions' could be used. Conversely, for more specific associations (like 'gene to disease association', the publication should be captured as an edge property)." ;
    skos:inScheme biolink: .

biolink:Invertebrate a owl:Class ;
    rdfs:label "invertebrate" ;
    rdfs:subClassOf biolink:CellularOrganism ;
    skos:exactMatch STY:T011,
        <http://purl.obolibrary.org/obo/FOODON_00002452>,
        <http://purl.obolibrary.org/obo/NCIT_C14228>,
        <http://purl.obolibrary.org/obo/OMIT_0008565> ;
    skos:inScheme biolink: ;
    skos:relatedMatch <http://purl.obolibrary.org/obo/NCBITaxon_1767184> .

biolink:JournalArticle a owl:Class ;
    rdfs:label "journal article" ;
    rdfs:subClassOf biolink:Article ;
    skos:definition "an article, typically presenting results of research, that is published in an issue of a scientific journal." ;
    skos:exactMatch IAO:0000013,
        fabio:JournalArticle ;
    skos:inScheme biolink: .

<https://w3id.org/biolink/vocab/KnowledgeLevelEnum#knowledge_assertion> a owl:Class ;
    rdfs:label "knowledge_assertion" ;
    rdfs:subClassOf biolink:KnowledgeLevelEnum,
        linkml:PermissibleValue ;
    skos:altLabel "assertion" ;
    skos:definition "A statement of purported fact that is put forth by an agent as true, based on assessment of direct evidence. Assertions are likely but not definitively true." ;
    skos:editorialNote "Knowledge Assertions are supported by direct evidence deemed sufficient by some agent to support a confidence assertion of truth. Our certainty in this truth is not absolute, but is typically higher than for Predictions." .

<https://w3id.org/biolink/vocab/KnowledgeLevelEnum#logical_entailment> a owl:Class ;
    rdfs:label "logical_entailment" ;
    rdfs:subClassOf biolink:KnowledgeLevelEnum,
        linkml:PermissibleValue ;
    skos:altLabel "deductive_inference" ;
    skos:definition "A statement reporting a conclusion that follows logically from premises representing established facts or knowledge assertions (e.g. fingernail part of finger, finger part of hand --> fingernail part of hand)." ;
    skos:editorialNote "These statements report entailed conclusions derived through dedictive inference. They are not directly asserted by a source, but logically follow from statement(s) a source does make - and are necessarily true if their supporting premises are true. In practice, these will primarily be entailments based on logic encoded in ontologies. Examples include propagation of annotated knowledge to hierarchically-related concepts, across paths through a graph constructed from transitive relationships, or sets of relationships that support property chain inference." .

<https://w3id.org/biolink/vocab/KnowledgeLevelEnum#not_provided> a owl:Class ;
    rdfs:label "not_provided" ;
    rdfs:subClassOf biolink:KnowledgeLevelEnum,
        linkml:PermissibleValue ;
    skos:definition "The knowledge level is not provided, typically because it cannot be determined from available. information." ;
    skos:editorialNote "This term is most often applied for text-mined edges, as NLP tools are typically not able to detect a specific knowledge level for the concept relationships they extract (e.g. whether the author was predicting or asserting a relationship, or merely observed it to occur)." .

<https://w3id.org/biolink/vocab/KnowledgeLevelEnum#observation> a owl:Class ;
    rdfs:label "observation" ;
    rdfs:subClassOf biolink:KnowledgeLevelEnum,
        linkml:PermissibleValue ;
    skos:definition "A statement reporting (and possibly quantifying) a phenomenon that was observed to occur - absent any analysis or interpretation that generates a statistical association or supports a broader conclusion or inference." ;
    skos:editorialNote "An observation that \"56362 people self-reported taking melatonin to treat migraines\" is agnostic to whether melatonin is an effective or approved treatment - it only claims that it was taken for this purpose. Such observations, however, may be used as the basis for predicting that a drug may be efficacious against a disease." .

<https://w3id.org/biolink/vocab/KnowledgeLevelEnum#prediction> a owl:Class ;
    rdfs:label "prediction" ;
    rdfs:subClassOf biolink:KnowledgeLevelEnum,
        linkml:PermissibleValue ;
    skos:altLabel "hypothesis" ;
    skos:definition "A statement of a possible fact based on probabilistic forms of reasoning over more indirect forms of evidence, that lead to more speculative conclusions." ;
    skos:editorialNote "Predictions typically result from non-deductive forms of reasoning - e.g. inductive and deductive inference, or statistical inference where conclusions are drawn about a broader/global population based on data from a representative cohort. For example, a prediction that a drug may treat a particular disease based on its chemical similarity to known drugs that treat the disease, and the fact that it can inhibit proteins in a pathway that is associated with the disease As Predictions are based on weaker forms of inference and evidence, they are typically considered lower confidence statements as compared to Knowledge Assertions and Logical Entailments." .

<https://w3id.org/biolink/vocab/KnowledgeLevelEnum#statistical_association> a owl:Class ;
    rdfs:label "statistical_association" ;
    rdfs:subClassOf biolink:KnowledgeLevelEnum,
        linkml:PermissibleValue ;
    skos:definition "A statement that reports concepts representing variables in a dataset to be statistically associated with each other in a particular cohort (e.g. 'Metformin Treatment (variable 1) is correlated with Diabetes Diagnosis (variable 2) in EHR dataset X')." ;
    skos:editorialNote "Such statements report the direct results of some statistical analysis. Their scope is limited tp the cohort/dataset interrogated in the analysis, and they do not make broader claims or draw more meaningful conclusions about the domain of discourse. Note however that such Statistical Associations can be used as evidence to support a more pointed/precise Prediction or Assertion of knowledge. For example, e.g. a Statistical Association between 'Metformin Prescription' and 'Diabetes Diagnosis' in EHR records could support a Prediction that 'Metformin treats Diabetes', or 'Metformin causes Diabetes'. This 'treats' edge may have a knowledge_level of 'Prediction', but the provider could use the 'evidence_type' edge property to indicate that this prediction is based on a 'Statistical Association'. Because Statistical Associations directly report analysis-specific results, we can consider them to be inherently true statements, whose broader utility is dependent on subsequent generalization of the reported result to a broader population, and/or interpretation of the result as support for a more meaningful statements about the domain of discourse." .

<https://w3id.org/biolink/vocab/KnowledgeLevelEnum#text_co_occurrence> a owl:Class ;
    rdfs:label "text_co_occurrence" ;
    rdfs:subClassOf biolink:KnowledgeLevelEnum,
        linkml:PermissibleValue ;
    skos:definition "A statement reporting that mentions of two concepts in some corpus of text (e.g. the biomedical literature) occur together at a statistically significant frequency - suggesting that a real-world biological or clinical relationship may exist between the concepts." ;
    skos:editorialNote "Such statements often utilize NLP/text-mining to identify concept mentions in text, but the reported statement is generated by a data analysis pipeline that performs calculations on mention counts and determines the strength of their correlation." .

<https://w3id.org/biolink/vocab/LogicalInterpretationEnum#inverse_all_some> a owl:Class ;
    rdfs:label "inverse_all_some" ;
    rdfs:subClassOf biolink:LogicalInterpretationEnum,
        linkml:PermissibleValue .

biolink:MacromolecularMachineHasSubstrateAssociation a owl:Class ;
    rdfs:label "macromolecular machine has substrate association" ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:allValuesFrom biolink:MacromolecularMachineMixin ;
            owl:onProperty biolink:subject ],
        [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:object_form_or_variant_qualifier ],
        [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:causal_mechanism_qualifier ],
        [ a owl:Restriction ;
            owl:minCardinality 0 ;
            owl:onProperty biolink:object_part_qualifier ],
        [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:subject ],
        [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:qualified_predicate ],
        [ a owl:Restriction ;
            owl:minCardinality 0 ;
            owl:onProperty biolink:anatomical_context_qualifier ],
        [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:object_part_qualifier ],
        [ a owl:Restriction ;
            owl:minCardinality 0 ;
            owl:onProperty biolink:subject_part_qualifier ],
        [ a owl:Restriction ;
            owl:allValuesFrom xsd:string ;
            owl:onProperty biolink:subject_context_qualifier ],
        [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:object ],
        [ a owl:Restriction ;
            owl:allValuesFrom xsd:string ;
            owl:onProperty biolink:anatomical_context_qualifier ],
        [ a owl:Restriction ;
            owl:minCardinality 1 ;
            owl:onProperty biolink:predicate ],
        [ a owl:Restriction ;
            owl:allValuesFrom xsd:string ;
            owl:onProperty biolink:predicate ],
        [ a owl:Restriction ;
            owl:allValuesFrom xsd:string ;
            owl:onProperty biolink:subject_form_or_variant_qualifier ],
        [ a owl:Restriction ;
            owl:minCardinality 0 ;
            owl:onProperty biolink:causal_mechanism_qualifier ],
        [ a owl:Restriction ;
            owl:allValuesFrom biolink:GeneOrGeneProductOrChemicalEntityAspectEnum ;
            owl:onProperty biolink:object_aspect_qualifier ],
        [ a owl:Restriction ;
            owl:minCardinality 0 ;
            owl:onProperty biolink:object_direction_qualifier ],
        [ a owl:Restriction ;
            owl:allValuesFrom xsd:string ;
            owl:onProperty biolink:subject_derivative_qualifier ],
        [ a owl:Restriction ;
            owl:minCardinality 0 ;
            owl:onProperty biolink:subject_context_qualifier ],
        [ a owl:Restriction ;
            owl:allValuesFrom biolink:DirectionQualifierEnum ;
            owl:onProperty biolink:subject_direction_qualifier ],
        [ a owl:Restriction ;
            owl:minCardinality 0 ;
            owl:onProperty biolink:object_form_or_variant_qualifier ],
        [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:subject_aspect_qualifier ],
        [ a owl:Restriction ;
            owl:allValuesFrom biolink:DirectionQualifierEnum ;
            owl:onProperty biolink:object_direction_qualifier ],
        [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:subject_derivative_qualifier ],
        [ a owl:Restriction ;
            owl:allValuesFrom xsd:anyURI ;
            owl:onProperty biolink:qualified_predicate ],
        [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:object_context_qualifier ],
        [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:subject_direction_qualifier ],
        [ a owl:Restriction ;
            owl:allValuesFrom xsd:string ;
            owl:onProperty biolink:object_context_qualifier ],
        [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:subject_context_qualifier ],
        [ a owl:Restriction ;
            owl:minCardinality 1 ;
            owl:onProperty biolink:object ],
        [ a owl:Restriction ;
            owl:minCardinality 0 ;
            owl:onProperty biolink:object_aspect_qualifier ],
        [ a owl:Restriction ;
            owl:minCardinality 0 ;
            owl:onProperty biolink:species_context_qualifier ],
        [ a owl:Restriction ;
            owl:allValuesFrom biolink:OrganismTaxon ;
            owl:onProperty biolink:species_context_qualifier ],
        [ a owl:Restriction ;
            owl:allValuesFrom xsd:string ;
            owl:onProperty biolink:object_form_or_variant_qualifier ],
        [ a owl:Restriction ;
            owl:allValuesFrom biolink:CausalMechanismQualifierEnum ;
            owl:onProperty biolink:causal_mechanism_qualifier ],
        [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:object_direction_qualifier ],
        [ a owl:Restriction ;
            owl:minCardinality 0 ;
            owl:onProperty biolink:qualified_predicate ],
        [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:subject_part_qualifier ],
        [ a owl:Restriction ;
            owl:minCardinality 0 ;
            owl:onProperty biolink:object_context_qualifier ],
        [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:predicate ],
        [ a owl:Restriction ;
            owl:minCardinality 0 ;
            owl:onProperty biolink:subject_derivative_qualifier ],
        [ a owl:Restriction ;
            owl:minCardinality 0 ;
            owl:onProperty biolink:subject_direction_qualifier ],
        [ a owl:Restriction ;
            owl:allValuesFrom xsd:string ;
            owl:onProperty biolink:object_part_qualifier ],
        [ a owl:Restriction ;
            owl:minCardinality 0 ;
            owl:onProperty biolink:subject_form_or_variant_qualifier ],
        [ a owl:Restriction ;
            owl:minCardinality 0 ;
            owl:onProperty biolink:subject_aspect_qualifier ],
        [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:species_context_qualifier ],
        [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:object_aspect_qualifier ],
        [ a owl:Restriction ;
            owl:allValuesFrom xsd:string ;
            owl:onProperty biolink:subject_part_qualifier ],
        [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:subject_form_or_variant_qualifier ],
        [ a owl:Restriction ;
            owl:minCardinality 1 ;
            owl:onProperty biolink:subject ],
        [ a owl:Restriction ;
            owl:allValuesFrom biolink:GeneOrGeneProductOrChemicalEntityAspectEnum ;
            owl:onProperty biolink:subject_aspect_qualifier ],
        [ a owl:Restriction ;
            owl:allValuesFrom biolink:ChemicalEntityOrProteinOrPolypeptide ;
            owl:onProperty biolink:object ],
        biolink:Association ;
    skos:definition "Describes the relationship between an enzyme (usually a macromolecular complex or gene product) and the molecules it acts on (substrate). The substrate can be a chemical, a polypeptide, or a protein." ;
    skos:editorialNote "Using macromolecular machine should cover cases of gene-protein conflation." ;
    skos:inScheme biolink: .

biolink:MacromolecularMachineToBiologicalProcessAssociation a owl:Class ;
    rdfs:label "macromolecular machine to biological process association" ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:object ],
        [ a owl:Restriction ;
            owl:minCardinality 1 ;
            owl:onProperty biolink:object ],
        [ a owl:Restriction ;
            owl:allValuesFrom biolink:BiologicalProcess ;
            owl:onProperty biolink:object ],
        [ a owl:Restriction ;
            owl:onProperty linkml:mixins ;
            owl:someValuesFrom biolink:MacromolecularMachineToEntityAssociationMixin ],
        biolink:FunctionalAssociation ;
    skos:definition "A functional association between a macromolecular machine (gene, gene product or complex) and a biological process or pathway (as represented in the GO biological process branch), where the entity carries out some part of the process, regulates it, or acts upstream of it." ;
    skos:inScheme biolink: .

biolink:MacromolecularMachineToCellularComponentAssociation a owl:Class ;
    rdfs:label "macromolecular machine to cellular component association" ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:object ],
        [ a owl:Restriction ;
            owl:onProperty linkml:mixins ;
            owl:someValuesFrom biolink:MacromolecularMachineToEntityAssociationMixin ],
        [ a owl:Restriction ;
            owl:minCardinality 1 ;
            owl:onProperty biolink:object ],
        [ a owl:Restriction ;
            owl:allValuesFrom biolink:CellularComponent ;
            owl:onProperty biolink:object ],
        biolink:FunctionalAssociation ;
    skos:definition "A functional association between a macromolecular machine (gene, gene product or complex) and a cellular component (as represented in the GO cellular component branch), where the entity carries out its function in the cellular component." ;
    skos:inScheme biolink: .

biolink:MacromolecularMachineToMolecularActivityAssociation a owl:Class ;
    rdfs:label "macromolecular machine to molecular activity association" ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:minCardinality 1 ;
            owl:onProperty biolink:object ],
        [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:object ],
        [ a owl:Restriction ;
            owl:onProperty linkml:mixins ;
            owl:someValuesFrom biolink:MacromolecularMachineToEntityAssociationMixin ],
        [ a owl:Restriction ;
            owl:allValuesFrom biolink:MolecularActivity ;
            owl:onProperty biolink:object ],
        biolink:FunctionalAssociation ;
    skos:definition "A functional association between a macromolecular machine (gene, gene product or complex) and a molecular activity (as represented in the GO molecular function branch), where the entity carries out the activity, or contributes to its execution." ;
    skos:inScheme biolink: .

biolink:MaterialSampleDerivationAssociation a owl:Class ;
    rdfs:label "material sample derivation association" ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:minCardinality 1 ;
            owl:onProperty biolink:predicate ],
        [ a owl:Restriction ;
            owl:allValuesFrom biolink:MaterialSample ;
            owl:onProperty biolink:subject ],
        [ a owl:Restriction ;
            owl:allValuesFrom xsd:anyURI ;
            owl:onProperty biolink:predicate ],
        [ a owl:Restriction ;
            owl:minCardinality 1 ;
            owl:onProperty biolink:object ],
        [ a owl:Restriction ;
            owl:allValuesFrom biolink:NamedThing ;
            owl:onProperty biolink:object ],
        [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:predicate ],
        [ a owl:Restriction ;
            owl:minCardinality 1 ;
            owl:onProperty biolink:subject ],
        [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:subject ],
        [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:object ],
        biolink:Association ;
    skos:definition "An association between a material sample and the material entity from which it is derived." ;
    skos:inScheme biolink: .

biolink:MaterialSampleToDiseaseOrPhenotypicFeatureAssociation a owl:Class ;
    rdfs:label "material sample to disease or phenotypic feature association" ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:onProperty linkml:mixins ;
            owl:someValuesFrom biolink:EntityToDiseaseOrPhenotypicFeatureAssociationMixin ],
        [ a owl:Restriction ;
            owl:onProperty linkml:mixins ;
            owl:someValuesFrom biolink:MaterialSampleToEntityAssociationMixin ],
        biolink:Association ;
    skos:definition "An association between a material sample and a disease or phenotype." ;
    skos:inScheme biolink: .

biolink:MaterialSampleToEntityAssociationMixin a owl:Class ;
    rdfs:label "material sample to entity association mixin" ;
    rdfs:subClassOf <https://w3id.org/linkml/ClassDefinition#Mixin> ;
    skos:definition "An association between a material sample and something." ;
    skos:inScheme biolink: .

biolink:MicroRNA a owl:Class ;
    rdfs:label "microRNA" ;
    rdfs:subClassOf biolink:NoncodingRNAProduct ;
    skos:definition "A small (~22 nucleotide) RNA molecule that is the endogenous transcript of a miRNA gene. Produced from precursor molecules that form hairpin structures, which are processed (typically via the Dicer pathway) to yield a single miRNA molecule. miRNAs function by triggering cleavage of target molecules or acting as translational repressors." ;
    skos:exactMatch <http://purl.obolibrary.org/obo/SO_0000276>,
        SIO:001397,
        WIKIDATA:Q310899 ;
    skos:inScheme biolink: .

biolink:MolecularActivityToChemicalEntityAssociation a owl:Class ;
    rdfs:label "molecular activity to chemical entity association" ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:minCardinality 1 ;
            owl:onProperty biolink:object ],
        [ a owl:Restriction ;
            owl:allValuesFrom biolink:MolecularActivity ;
            owl:onProperty biolink:subject ],
        [ a owl:Restriction ;
            owl:allValuesFrom biolink:ChemicalEntity ;
            owl:onProperty biolink:object ],
        [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:object ],
        [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:subject ],
        [ a owl:Restriction ;
            owl:minCardinality 1 ;
            owl:onProperty biolink:subject ],
        biolink:Association ;
    skos:definition "Added in response to capturing relationship between microbiome activities as measured via measurements of blood analytes as collected via blood and stool samples" ;
    skos:inScheme biolink: .

biolink:MolecularActivityToMolecularActivityAssociation a owl:Class ;
    rdfs:label "molecular activity to molecular activity association" ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:object ],
        [ a owl:Restriction ;
            owl:minCardinality 1 ;
            owl:onProperty biolink:subject ],
        [ a owl:Restriction ;
            owl:minCardinality 1 ;
            owl:onProperty biolink:object ],
        [ a owl:Restriction ;
            owl:allValuesFrom biolink:MolecularActivity ;
            owl:onProperty biolink:subject ],
        [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:subject ],
        [ a owl:Restriction ;
            owl:allValuesFrom biolink:MolecularActivity ;
            owl:onProperty biolink:object ],
        biolink:Association ;
    skos:definition "Added in response to capturing relationship between microbiome activities as measured via measurements of blood analytes as collected via blood and stool samples" ;
    skos:inScheme biolink: .

biolink:MolecularActivityToPathwayAssociation a owl:Class ;
    rdfs:label "molecular activity to pathway association" ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:allValuesFrom biolink:MolecularActivity ;
            owl:onProperty biolink:subject ],
        [ a owl:Restriction ;
            owl:allValuesFrom xsd:string ;
            owl:onProperty biolink:predicate ],
        [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:subject ],
        [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:object ],
        [ a owl:Restriction ;
            owl:minCardinality 1 ;
            owl:onProperty biolink:subject ],
        [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:predicate ],
        [ a owl:Restriction ;
            owl:allValuesFrom biolink:Pathway ;
            owl:onProperty biolink:object ],
        [ a owl:Restriction ;
            owl:minCardinality 1 ;
            owl:onProperty biolink:object ],
        [ a owl:Restriction ;
            owl:minCardinality 1 ;
            owl:onProperty biolink:predicate ],
        biolink:Association ;
    skos:definition "Association that holds the relationship between a reaction and the pathway it participates in." ;
    skos:inScheme biolink: .

biolink:NamedThingAssociatedWithLikelihoodOfNamedThingAssociation a owl:Class ;
    rdfs:label "named thing associated with likelihood of named thing association" ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:allValuesFrom biolink:OntologyClass ;
            owl:onProperty biolink:subject_context_qualifier ],
        [ a owl:Restriction ;
            owl:allValuesFrom biolink:GeneOrGeneProductOrChemicalEntityAspectEnum ;
            owl:onProperty biolink:subject_aspect_qualifier ],
        [ a owl:Restriction ;
            owl:minCardinality 1 ;
            owl:onProperty biolink:object ],
        [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:predicate ],
        [ a owl:Restriction ;
            owl:minCardinality 0 ;
            owl:onProperty biolink:subject_aspect_qualifier ],
        [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:population_context_qualifier ],
        [ a owl:Restriction ;
            owl:allValuesFrom xsd:anyURI ;
            owl:onProperty biolink:predicate ],
        [ a owl:Restriction ;
            owl:minCardinality 0 ;
            owl:onProperty biolink:object_context_qualifier ],
        [ a owl:Restriction ;
            owl:minCardinality 1 ;
            owl:onProperty biolink:predicate ],
        [ a owl:Restriction ;
            owl:allValuesFrom biolink:PopulationOfIndividualOrganisms ;
            owl:onProperty biolink:population_context_qualifier ],
        [ a owl:Restriction ;
            owl:allValuesFrom biolink:OntologyClass ;
            owl:onProperty biolink:object_context_qualifier ],
        [ a owl:Restriction ;
            owl:minCardinality 0 ;
            owl:onProperty biolink:object_aspect_qualifier ],
        [ a owl:Restriction ;
            owl:minCardinality 0 ;
            owl:onProperty biolink:subject_context_qualifier ],
        [ a owl:Restriction ;
            owl:allValuesFrom biolink:NamedThing ;
            owl:onProperty biolink:subject ],
        [ a owl:Restriction ;
            owl:allValuesFrom biolink:GeneOrGeneProductOrChemicalEntityAspectEnum ;
            owl:onProperty biolink:object_aspect_qualifier ],
        [ a owl:Restriction ;
            owl:minCardinality 0 ;
            owl:onProperty biolink:population_context_qualifier ],
        [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:object_aspect_qualifier ],
        [ a owl:Restriction ;
            owl:allValuesFrom biolink:NamedThing ;
            owl:onProperty biolink:object ],
        [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:object_context_qualifier ],
        [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:subject ],
        [ a owl:Restriction ;
            owl:minCardinality 1 ;
            owl:onProperty biolink:subject ],
        [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:subject_aspect_qualifier ],
        [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:object ],
        [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:subject_context_qualifier ],
        biolink:Association ;
    skos:definition "An association in which the subject entity is linked to the likelihood of the object entity occurring, manifesting, or being observed. Subject and object may each be qualified by aspect and context, and the association may be further qualified by a population context." ;
    skos:inScheme biolink: .

biolink:OrganismTaxonToEnvironmentAssociation a owl:Class ;
    rdfs:label "organism taxon to environment association" ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:allValuesFrom owl:Thing ;
            owl:onProperty biolink:object ],
        [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:object ],
        [ a owl:Restriction ;
            owl:minCardinality 1 ;
            owl:onProperty biolink:subject ],
        [ a owl:Restriction ;
            owl:onProperty linkml:mixins ;
            owl:someValuesFrom biolink:OrganismTaxonToEntityAssociation ],
        [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:predicate ],
        [ a owl:Restriction ;
            owl:minCardinality 1 ;
            owl:onProperty biolink:object ],
        [ a owl:Restriction ;
            owl:minCardinality 1 ;
            owl:onProperty biolink:predicate ],
        [ a owl:Restriction ;
            owl:allValuesFrom xsd:string ;
            owl:onProperty biolink:predicate ],
        [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:subject ],
        [ a owl:Restriction ;
            owl:allValuesFrom biolink:OrganismTaxon ;
            owl:onProperty biolink:subject ],
        biolink:Association ;
    skos:definition "An abstract association between an organism taxon and an environmental context (e.g., a habitat, biome, or ecological setting) in which the taxon occurs." ;
    skos:inScheme biolink: .

biolink:OrganismToOrganismAssociation a owl:Class ;
    rdfs:label "organism to organism association" ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:allValuesFrom biolink:IndividualOrganism ;
            owl:onProperty biolink:object ],
        [ a owl:Restriction ;
            owl:minCardinality 1 ;
            owl:onProperty biolink:object ],
        [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:subject ],
        [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:object ],
        [ a owl:Restriction ;
            owl:allValuesFrom biolink:IndividualOrganism ;
            owl:onProperty biolink:subject ],
        [ a owl:Restriction ;
            owl:minCardinality 1 ;
            owl:onProperty biolink:subject ],
        biolink:Association ;
    skos:definition "An association between two individual organisms (e.g., symbiosis, parasitism, predation, or other inter-organism relationships)." ;
    skos:inScheme biolink: .

biolink:OrganismalEntityAsAModelOfDiseaseAssociation a owl:Class ;
    rdfs:label "organismal entity as a model of disease association" ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:minCardinality 1 ;
            owl:onProperty biolink:subject ],
        [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:subject ],
        [ a owl:Restriction ;
            owl:onProperty linkml:mixins ;
            owl:someValuesFrom biolink:EntityToDiseaseAssociationMixin ],
        [ a owl:Restriction ;
            owl:allValuesFrom biolink:OrganismalEntity ;
            owl:onProperty biolink:subject ],
        [ a owl:Restriction ;
            owl:onProperty linkml:mixins ;
            owl:someValuesFrom biolink:ModelToDiseaseAssociationMixin ],
        biolink:Association ;
    skos:definition "An association in which an organismal entity (e.g., a strain or breed) serves as a model of a disease, either because it has a natural predisposition to the disease or was bred or engineered specifically to recapitulate it." ;
    skos:inScheme biolink: .

biolink:PairwiseMolecularInteraction a owl:Class ;
    rdfs:label "pairwise molecular interaction" ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:allValuesFrom biolink:MolecularEntity ;
            owl:onProperty biolink:subject ],
        [ a owl:Restriction ;
            owl:minCardinality 1 ;
            owl:onProperty biolink:predicate ],
        [ a owl:Restriction ;
            owl:allValuesFrom biolink:OntologyClass ;
            owl:onProperty biolink:interacting_molecules_category ],
        [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:subject ],
        [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:interacting_molecules_category ],
        [ a owl:Restriction ;
            owl:minCardinality 0 ;
            owl:onProperty biolink:interacting_molecules_category ],
        [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:id ],
        [ a owl:Restriction ;
            owl:allValuesFrom xsd:string ;
            owl:onProperty biolink:predicate ],
        [ a owl:Restriction ;
            owl:minCardinality 1 ;
            owl:onProperty biolink:subject ],
        [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:object ],
        [ a owl:Restriction ;
            owl:allValuesFrom biolink:MolecularEntity ;
            owl:onProperty biolink:object ],
        [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:predicate ],
        [ a owl:Restriction ;
            owl:minCardinality 1 ;
            owl:onProperty biolink:object ],
        [ a owl:Restriction ;
            owl:minCardinality 1 ;
            owl:onProperty biolink:id ],
        [ a owl:Restriction ;
            owl:allValuesFrom xsd:string ;
            owl:onProperty biolink:id ],
        biolink:PairwiseGeneToGeneInteraction ;
    skos:definition "An interaction at the molecular level between two physical entities" ;
    skos:inScheme biolink: .

biolink:Patent a owl:Class ;
    rdfs:label "patent" ;
    rdfs:subClassOf biolink:Publication ;
    skos:definition "a legal document granted by a patent issuing authority which confers upon the patenter the sole right to make, use and sell an invention for a set period of time." ;
    skos:exactMatch IAO:0000313,
        fabio:Patent,
        SIO:000153 ;
    skos:inScheme biolink: .

biolink:PathologicalAnatomicalExposure a owl:Class ;
    rdfs:label "pathological anatomical exposure" ;
    rdfs:subClassOf biolink:ExposureEvent ;
    skos:definition "An abnormal anatomical structure, when viewed as an exposure, represented as a precondition, leading to or influencing an outcome." ;
    skos:inScheme biolink: .

biolink:PathologicalAnatomicalStructure a owl:Class ;
    rdfs:label "pathological anatomical structure" ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:onProperty linkml:mixins ;
            owl:someValuesFrom biolink:PathologicalEntityMixin ],
        biolink:AnatomicalEntity ;
    skos:definition "An anatomical structure with the potential of have an abnormal or deleterious effect at the subcellular, cellular, multicellular, or organismal level." ;
    skos:exactMatch <http://purl.obolibrary.org/obo/MPATH_603> ;
    skos:inScheme biolink: .

biolink:PathologicalProcess a owl:Class ;
    rdfs:label "pathological process" ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:onProperty linkml:mixins ;
            owl:someValuesFrom biolink:PathologicalEntityMixin ],
        biolink:BiologicalProcess ;
    skos:definition "A biologic function or a process having an abnormal or deleterious effect at the subcellular, cellular, multicellular, or organismal level." ;
    skos:exactMatch <http://purl.obolibrary.org/obo/MPATH_596>,
        <http://purl.obolibrary.org/obo/NCIT_C16956>,
        <http://purl.obolibrary.org/obo/OBI_1110122> ;
    skos:inScheme biolink: ;
    skos:narrowMatch STY:T037,
        STY:T046,
        <http://purl.obolibrary.org/obo/NCIT_C19151>,
        EFO:0009708 .

biolink:PathologicalProcessExposure a owl:Class ;
    rdfs:label "pathological process exposure" ;
    rdfs:subClassOf biolink:ExposureEvent ;
    skos:definition "A pathological process, when viewed as an exposure, representing a precondition, leading to or influencing an outcome." ;
    skos:inScheme biolink: .

<https://w3id.org/biolink/vocab/PhaseEnum#0> a owl:Class ;
    rdfs:label "0" ;
    rdfs:subClassOf biolink:PhaseEnum,
        linkml:PermissibleValue .

<https://w3id.org/biolink/vocab/PhaseEnum#1> a owl:Class ;
    rdfs:label "1" ;
    rdfs:subClassOf biolink:PhaseEnum,
        linkml:PermissibleValue .

<https://w3id.org/biolink/vocab/PhaseEnum#2> a owl:Class ;
    rdfs:label "2" ;
    rdfs:subClassOf biolink:PhaseEnum,
        linkml:PermissibleValue .

biolink:Phenomenon a owl:Class ;
    rdfs:label "phenomenon" ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:onProperty linkml:mixins ;
            owl:someValuesFrom biolink:Occurrent ],
        biolink:NamedThing ;
    skos:broadMatch STY:T067,
        STY:T068,
        STY:T070 ;
    skos:definition "a fact or situation that is observed to exist or happen, especially one whose cause or explanation is in question" ;
    skos:exactMatch UMLSSG:PHEN ;
    skos:inScheme biolink: ;
    skos:narrowMatch STY:T034,
        STY:T038,
        STY:T069 .

biolink:PhenotypicFeatureToDiseaseAssociation a owl:Class ;
    rdfs:label "phenotypic feature to disease association" ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:predicate ],
        [ a owl:Restriction ;
            owl:allValuesFrom xsd:string ;
            owl:onProperty biolink:predicate ],
        [ a owl:Restriction ;
            owl:minCardinality 1 ;
            owl:onProperty biolink:predicate ],
        [ a owl:Restriction ;
            owl:onProperty linkml:mixins ;
            owl:someValuesFrom biolink:EntityToDiseaseAssociationMixin ],
        [ a owl:Restriction ;
            owl:onProperty linkml:mixins ;
            owl:someValuesFrom biolink:PhenotypicFeatureToEntityAssociationMixin ],
        biolink:Association ;
    skos:definition "An association between a phenotypic feature (sign or symptom) and a disease, where the phenotypic feature is a manifestation or clinical indicator of the disease." ;
    skos:inScheme biolink: .

biolink:PhenotypicFeatureToPhenotypicFeatureAssociation a owl:Class ;
    rdfs:label "phenotypic feature to phenotypic feature association" ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:onProperty linkml:mixins ;
            owl:someValuesFrom biolink:EntityToPhenotypicFeatureAssociationMixin ],
        [ a owl:Restriction ;
            owl:onProperty linkml:mixins ;
            owl:someValuesFrom biolink:PhenotypicFeatureToEntityAssociationMixin ],
        biolink:Association ;
    skos:definition "Association between two concept nodes of phenotypic character, qualified by the predicate used. This association may typically be used to specify 'similar_to' or 'member_of' relationships." ;
    skos:inScheme biolink: .

biolink:PhenotypicQuality a owl:Class ;
    rdfs:label "phenotypic quality" ;
    rdfs:subClassOf biolink:OrganismAttribute ;
    skos:altLabel "phenotypic properties" ;
    skos:broadMatch <http://purl.obolibrary.org/obo/PATO_0001995> ;
    skos:definition "A characteristic of a phenotype (e.g., weight, size, shape, color) that can be observed, measured, or compared across organisms or conditions." ;
    skos:inScheme biolink: .

biolink:PhenotypicSex a owl:Class ;
    rdfs:label "phenotypic sex" ;
    rdfs:subClassOf biolink:BiologicalSex ;
    skos:definition "An attribute corresponding to the phenotypic sex of the individual, based upon the reproductive organs present." ;
    skos:exactMatch <http://purl.obolibrary.org/obo/PATO_0001894> ;
    skos:inScheme biolink: .

biolink:PhysiologicalProcess a owl:Class ;
    rdfs:label "physiological process" ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:onProperty linkml:mixins ;
            owl:someValuesFrom biolink:OntologyClass ],
        biolink:BiologicalProcess ;
    skos:altLabel "physiology" ;
    skos:definition "A biological or chemical function within a living organism." ;
    skos:exactMatch STY:T039,
        WIKIDATA:Q30892994 ;
    skos:inScheme biolink: ;
    skos:narrowMatch STY:T040,
        STY:T042,
        STY:T043,
        STY:T045 .

biolink:Plant a owl:Class ;
    rdfs:label "plant" ;
    rdfs:subClassOf biolink:CellularOrganism ;
    skos:exactMatch STY:T002,
        <http://purl.obolibrary.org/obo/NCIT_C14258>,
        <http://purl.obolibrary.org/obo/NCIT_C79659>,
        <http://purl.obolibrary.org/obo/PO_0000003> ;
    skos:inScheme biolink: .

biolink:PopulationToPopulationAssociation a owl:Class ;
    rdfs:label "population to population association" ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:allValuesFrom biolink:PopulationOfIndividualOrganisms ;
            owl:onProperty biolink:object ],
        [ a owl:Restriction ;
            owl:minCardinality 1 ;
            owl:onProperty biolink:predicate ],
        [ a owl:Restriction ;
            owl:allValuesFrom biolink:PopulationOfIndividualOrganisms ;
            owl:onProperty biolink:subject ],
        [ a owl:Restriction ;
            owl:minCardinality 1 ;
            owl:onProperty biolink:object ],
        [ a owl:Restriction ;
            owl:allValuesFrom xsd:string ;
            owl:onProperty biolink:predicate ],
        [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:predicate ],
        [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:object ],
        [ a owl:Restriction ;
            owl:minCardinality 1 ;
            owl:onProperty biolink:subject ],
        [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:subject ],
        biolink:Association ;
    skos:definition "An association between a two populations" ;
    skos:inScheme biolink: .

biolink:PredicateMapping a owl:Class ;
    rdfs:label "predicate mapping" ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:allValuesFrom xsd:string ;
            owl:onProperty biolink:object_context_qualifier ],
        [ a owl:Restriction ;
            owl:allValuesFrom biolink:GeneOrGeneProductOrChemicalEntityAspectEnum ;
            owl:onProperty biolink:object_aspect_qualifier ],
        [ a owl:Restriction ;
            owl:minCardinality 0 ;
            owl:onProperty biolink:causal_mechanism_qualifier ],
        [ a owl:Restriction ;
            owl:minCardinality 0 ;
            owl:onProperty biolink:species_context_qualifier ],
        [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:subject_derivative_qualifier ],
        [ a owl:Restriction ;
            owl:allValuesFrom xsd:string ;
            owl:onProperty biolink:mapped_predicate ],
        [ a owl:Restriction ;
            owl:minCardinality 0 ;
            owl:onProperty biolink:object_direction_qualifier ],
        [ a owl:Restriction ;
            owl:minCardinality 0 ;
            owl:onProperty biolink:exact_match ],
        [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:subject_direction_qualifier ],
        [ a owl:Restriction ;
            owl:allValuesFrom xsd:anyURI ;
            owl:onProperty biolink:predicate ],
        [ a owl:Restriction ;
            owl:allValuesFrom xsd:string ;
            owl:onProperty biolink:anatomical_context_qualifier ],
        [ a owl:Restriction ;
            owl:allValuesFrom xsd:string ;
            owl:onProperty biolink:subject_derivative_qualifier ],
        [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:predicate ],
        [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:subject_form_or_variant_qualifier ],
        [ a owl:Restriction ;
            owl:allValuesFrom biolink:DirectionQualifierEnum ;
            owl:onProperty biolink:subject_direction_qualifier ],
        [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:subject_part_qualifier ],
        [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:broad_match ],
        [ a owl:Restriction ;
            owl:allValuesFrom biolink:CausalMechanismQualifierEnum ;
            owl:onProperty biolink:causal_mechanism_qualifier ],
        [ a owl:Restriction ;
            owl:allValuesFrom xsd:string ;
            owl:onProperty biolink:subject_context_qualifier ],
        [ a owl:Restriction ;
            owl:allValuesFrom owl:Thing ;
            owl:onProperty biolink:exact_match ],
        [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:narrow_match ],
        [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:exact_match ],
        [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:object_part_qualifier ],
        [ a owl:Restriction ;
            owl:minCardinality 0 ;
            owl:onProperty biolink:subject_aspect_qualifier ],
        [ a owl:Restriction ;
            owl:allValuesFrom xsd:string ;
            owl:onProperty biolink:subject_form_or_variant_qualifier ],
        [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:object_direction_qualifier ],
        [ a owl:Restriction ;
            owl:minCardinality 0 ;
            owl:onProperty biolink:mapped_predicate ],
        [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:object_context_qualifier ],
        [ a owl:Restriction ;
            owl:minCardinality 0 ;
            owl:onProperty biolink:subject_form_or_variant_qualifier ],
        [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:causal_mechanism_qualifier ],
        [ a owl:Restriction ;
            owl:minCardinality 0 ;
            owl:onProperty biolink:broad_match ],
        [ a owl:Restriction ;
            owl:allValuesFrom xsd:string ;
            owl:onProperty biolink:object_form_or_variant_qualifier ],
        [ a owl:Restriction ;
            owl:minCardinality 0 ;
            owl:onProperty biolink:qualified_predicate ],
        [ a owl:Restriction ;
            owl:minCardinality 0 ;
            owl:onProperty biolink:object_aspect_qualifier ],
        [ a owl:Restriction ;
            owl:minCardinality 0 ;
            owl:onProperty biolink:object_part_qualifier ],
        [ a owl:Restriction ;
            owl:minCardinality 1 ;
            owl:onProperty biolink:predicate ],
        [ a owl:Restriction ;
            owl:minCardinality 0 ;
            owl:onProperty biolink:subject_derivative_qualifier ],
        [ a owl:Restriction ;
            owl:minCardinality 0 ;
            owl:onProperty biolink:narrow_match ],
        [ a owl:Restriction ;
            owl:allValuesFrom xsd:string ;
            owl:onProperty biolink:subject_part_qualifier ],
        [ a owl:Restriction ;
            owl:minCardinality 0 ;
            owl:onProperty biolink:subject_context_qualifier ],
        [ a owl:Restriction ;
            owl:allValuesFrom xsd:string ;
            owl:onProperty biolink:object_part_qualifier ],
        [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:object_aspect_qualifier ],
        [ a owl:Restriction ;
            owl:allValuesFrom xsd:string ;
            owl:onProperty biolink:object_derivative_qualifier ],
        [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:object_derivative_qualifier ],
        [ a owl:Restriction ;
            owl:minCardinality 0 ;
            owl:onProperty biolink:subject_part_qualifier ],
        [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:mapped_predicate ],
        [ a owl:Restriction ;
            owl:allValuesFrom biolink:OrganismTaxon ;
            owl:onProperty biolink:species_context_qualifier ],
        [ a owl:Restriction ;
            owl:allValuesFrom biolink:GeneOrGeneProductOrChemicalEntityAspectEnum ;
            owl:onProperty biolink:subject_aspect_qualifier ],
        [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:subject_context_qualifier ],
        [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:subject_aspect_qualifier ],
        [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:qualified_predicate ],
        [ a owl:Restriction ;
            owl:minCardinality 0 ;
            owl:onProperty biolink:object_derivative_qualifier ],
        [ a owl:Restriction ;
            owl:allValuesFrom xsd:anyURI ;
            owl:onProperty biolink:qualified_predicate ],
        [ a owl:Restriction ;
            owl:minCardinality 0 ;
            owl:onProperty biolink:anatomical_context_qualifier ],
        [ a owl:Restriction ;
            owl:minCardinality 0 ;
            owl:onProperty biolink:object_context_qualifier ],
        [ a owl:Restriction ;
            owl:minCardinality 0 ;
            owl:onProperty biolink:object_form_or_variant_qualifier ],
        [ a owl:Restriction ;
            owl:allValuesFrom owl:Thing ;
            owl:onProperty biolink:narrow_match ],
        [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:species_context_qualifier ],
        [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:object_form_or_variant_qualifier ],
        [ a owl:Restriction ;
            owl:allValuesFrom owl:Thing ;
            owl:onProperty biolink:broad_match ],
        [ a owl:Restriction ;
            owl:minCardinality 0 ;
            owl:onProperty biolink:subject_direction_qualifier ],
        [ a owl:Restriction ;
            owl:allValuesFrom biolink:DirectionQualifierEnum ;
            owl:onProperty biolink:object_direction_qualifier ],
        linkml:ClassDefinition ;
    skos:definition "A deprecated predicate mapping object contains the deprecated predicate and an example of the rewiring that should be done to use a qualified statement in its place." ;
    skos:inScheme biolink: .

biolink:PreprintPublication a owl:Class ;
    rdfs:label "preprint publication" ;
    rdfs:subClassOf biolink:Publication ;
    skos:definition "a document reresenting an early version of an author's original scholarly work, such as a research paper or a review, prior to formal peer review and publication in a peer-reviewed scholarly or scientific journal." ;
    skos:exactMatch fabio:Preprint,
        EFO:0010558 ;
    skos:inScheme biolink: .

biolink:ProcessRegulatesProcessAssociation a owl:Class ;
    rdfs:label "process regulates process association" ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:allValuesFrom biolink:BiologicalProcess ;
            owl:onProperty biolink:object ],
        [ a owl:Restriction ;
            owl:allValuesFrom xsd:string ;
            owl:onProperty biolink:predicate ],
        [ a owl:Restriction ;
            owl:minCardinality 1 ;
            owl:onProperty biolink:object ],
        [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:predicate ],
        [ a owl:Restriction ;
            owl:minCardinality 1 ;
            owl:onProperty biolink:subject ],
        [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:object ],
        [ a owl:Restriction ;
            owl:allValuesFrom biolink:BiologicalProcess ;
            owl:onProperty biolink:subject ],
        [ a owl:Restriction ;
            owl:minCardinality 1 ;
            owl:onProperty biolink:predicate ],
        [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:subject ],
        biolink:Association ;
    skos:definition "Describes a regulatory relationship between two genes or gene products." ;
    skos:inScheme biolink: .

biolink:ProcessedMaterial a owl:Class ;
    rdfs:label "processed material" ;
    rdfs:subClassOf biolink:ChemicalMixture ;
    skos:definition "A chemical entity (often a mixture) processed for consumption for nutritional, medical or technical use. Is a material entity that is created or changed during material processing." ;
    skos:exactMatch <COB:0000026> ;
    skos:inScheme biolink: .

biolink:ProteinIsoform a owl:Class ;
    rdfs:label "protein isoform" ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:onProperty linkml:mixins ;
            owl:someValuesFrom biolink:GeneProductIsoformMixin ],
        biolink:Protein ;
    skos:altLabel "proteoform" ;
    skos:definition "Represents a protein that is a specific isoform of the canonical or reference protein." ;
    skos:inScheme biolink: ;
    skos:note "See https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4114032/" .

biolink:RNAProductIsoform a owl:Class ;
    rdfs:label "RNA product isoform" ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:onProperty linkml:mixins ;
            owl:someValuesFrom biolink:GeneProductIsoformMixin ],
        biolink:RNAProduct ;
    skos:definition "Represents a protein that is a specific isoform of the canonical or reference RNA" ;
    skos:inScheme biolink: .

<https://w3id.org/biolink/vocab/ReactionDirectionEnum#bidirectional> a owl:Class ;
    rdfs:label "bidirectional" ;
    rdfs:subClassOf biolink:ReactionDirectionEnum,
        linkml:PermissibleValue .

<https://w3id.org/biolink/vocab/ReactionDirectionEnum#left_to_right> a owl:Class ;
    rdfs:label "left_to_right" ;
    rdfs:subClassOf biolink:ReactionDirectionEnum,
        linkml:PermissibleValue .

<https://w3id.org/biolink/vocab/ReactionDirectionEnum#neutral> a owl:Class ;
    rdfs:label "neutral" ;
    rdfs:subClassOf biolink:ReactionDirectionEnum,
        linkml:PermissibleValue .

<https://w3id.org/biolink/vocab/ReactionDirectionEnum#right_to_left> a owl:Class ;
    rdfs:label "right_to_left" ;
    rdfs:subClassOf biolink:ReactionDirectionEnum,
        linkml:PermissibleValue .

<https://w3id.org/biolink/vocab/ReactionSideEnum#left> a owl:Class ;
    rdfs:label "left" ;
    rdfs:subClassOf biolink:ReactionSideEnum,
        linkml:PermissibleValue .

<https://w3id.org/biolink/vocab/ReactionSideEnum#right> a owl:Class ;
    rdfs:label "right" ;
    rdfs:subClassOf biolink:ReactionSideEnum,
        linkml:PermissibleValue .

biolink:ReactionToCatalystAssociation a owl:Class ;
    rdfs:label "reaction to catalyst association" ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:allValuesFrom biolink:GeneOrGeneProduct ;
            owl:onProperty biolink:object ],
        [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:object ],
        [ a owl:Restriction ;
            owl:minCardinality 1 ;
            owl:onProperty biolink:object ],
        biolink:ReactionToParticipantAssociation ;
    skos:definition "A specialization of reaction-to-participant association in which the participant is a gene or gene product (e.g., an enzyme) that catalyses the reaction." ;
    skos:inScheme biolink: .

<https://w3id.org/biolink/vocab/ResearchPhaseEnum#clinical_trial_phase_1> a owl:Class ;
    rdfs:label "clinical_trial_phase_1" ;
    rdfs:subClassOf biolink:ResearchPhaseEnum,
        <https://w3id.org/biolink/vocab/ResearchPhaseEnum#clinical_trial_phase> ;
    skos:definition "In the FDA Clinical Trial Phase, the Clinical Trial Phase 1 involves 20 – 100 study participants and lasts several months. This phase is used to determine the safety and dosage of the drug, and about 70% of these drugs move on to the next clinical research phase." .

<https://w3id.org/biolink/vocab/ResearchPhaseEnum#clinical_trial_phase_1_to_2> a owl:Class ;
    rdfs:label "clinical_trial_phase_1_to_2" ;
    rdfs:seeAlso <https://www.cancer.gov/publications/dictionaries/cancer-terms/def/phase-i-ii-clinical-trial> ;
    rdfs:subClassOf biolink:ResearchPhaseEnum,
        <https://w3id.org/biolink/vocab/ResearchPhaseEnum#clinical_trial_phase> ;
    skos:definition "A study that tests the safety, side effects, and best dose of a new treatment. Phase I/II clinical trials also test how well a certain type of cancer or other disease responds to a new treatment. In the phase II part of the clinical trial, patients usually receive the highest dose of treatment that did not cause harmful side effects in the phase I part of the clinical trial. Combining phases I and II may allow research questions to be answered more quickly or with fewer patients. Also called phase 1/phase 2 clinical trial." .

<https://w3id.org/biolink/vocab/ResearchPhaseEnum#clinical_trial_phase_2> a owl:Class ;
    rdfs:label "clinical_trial_phase_2" ;
    rdfs:subClassOf biolink:ResearchPhaseEnum,
        <https://w3id.org/biolink/vocab/ResearchPhaseEnum#clinical_trial_phase> ;
    skos:definition "In the FDA Clinical Trial Phase, the Clinical Trial Phase 2 involves up to several hundred people, who must have the disease or condition the drug supposes to treat. This phase can last from a few months to two years, and its purpose is to monitor the efficacy of the drug, as well as note side effects that may occur." .

<https://w3id.org/biolink/vocab/ResearchPhaseEnum#clinical_trial_phase_2_to_3> a owl:Class ;
    rdfs:label "clinical_trial_phase_2_to_3" ;
    rdfs:seeAlso <https://www.cancer.gov/publications/dictionaries/cancer-terms/def/phase-ii-iii-clinical-trial> ;
    rdfs:subClassOf biolink:ResearchPhaseEnum,
        <https://w3id.org/biolink/vocab/ResearchPhaseEnum#clinical_trial_phase> ;
    skos:definition "A study that tests how well a new treatment works for a certain type of cancer or other disease and compares the new treatment with a standard treatment. Phase II/III clinical trials may also provide more information about the safety and side effects of the new treatment. Combining phases II and III may allow research questions to be answered more quickly or with fewer patients. Also called phase 2/phase 3 clinical trial." .

<https://w3id.org/biolink/vocab/ResearchPhaseEnum#clinical_trial_phase_3> a owl:Class ;
    rdfs:label "clinical_trial_phase_3" ;
    rdfs:subClassOf biolink:ResearchPhaseEnum,
        <https://w3id.org/biolink/vocab/ResearchPhaseEnum#clinical_trial_phase> ;
    skos:definition "In the FDA Clinical Trial Phase, the Clinical Trial Phase 3 involves 300 – 3000 volunteers and can last up to four years. It is used to continue monitoring the efficacy of the drug, as well as exploring any longer-term adverse reactions." .

<https://w3id.org/biolink/vocab/ResearchPhaseEnum#clinical_trial_phase_4> a owl:Class ;
    rdfs:label "clinical_trial_phase_4" ;
    rdfs:subClassOf biolink:ResearchPhaseEnum,
        <https://w3id.org/biolink/vocab/ResearchPhaseEnum#clinical_trial_phase> ;
    skos:definition "In the FDA Clinical Trial Phase, the Clinical Trial Phase 4 involves several thousands of volunteers who have the disease or condition and continues to monitor safety and efficacy. If a drug passes this phase, it goes on to FDA review." .

<https://w3id.org/biolink/vocab/ResearchPhaseEnum#not_provided> a owl:Class ;
    rdfs:label "not_provided" ;
    rdfs:subClassOf biolink:ResearchPhaseEnum,
        linkml:PermissibleValue .

<https://w3id.org/biolink/vocab/ResearchPhaseEnum#pre_clinical_research_phase> a owl:Class ;
    rdfs:label "pre_clinical_research_phase" ;
    rdfs:subClassOf biolink:ResearchPhaseEnum,
        linkml:PermissibleValue ;
    skos:definition "Biolink 'pre_clinical_research' is the union of both the `FDA discovery and development phase` and `FDA preclinical research phase`. Discovery involves researchers finding new possibilities for medication through testing molecular compounds, noting unexpected effects from existing treatments, or the creation of new technology that allows novel ways of targeting medical products to sites in the body. Drug development occurs after researchers identify potential compounds for experiments Preclinical Research Phase. Once researchers have examined the possibilities a new drug may contain, they must do preliminary research to determine its potential for harm (toxicity). This is categorized as preclinical research and can be one of two types: in vitro or in vivo." ;
    skos:editorialNote "DrugBank calls this 'experimental'." .

<https://w3id.org/biolink/vocab/ResourceRoleEnum#aggregator_knowledge_source> a owl:Class ;
    rdfs:label "aggregator_knowledge_source" ;
    rdfs:subClassOf biolink:ResourceRoleEnum,
        linkml:PermissibleValue .

<https://w3id.org/biolink/vocab/ResourceRoleEnum#primary_knowledge_source> a owl:Class ;
    rdfs:label "primary_knowledge_source" ;
    rdfs:subClassOf biolink:ResourceRoleEnum,
        linkml:PermissibleValue .

<https://w3id.org/biolink/vocab/ResourceRoleEnum#supporting_data_source> a owl:Class ;
    rdfs:label "supporting_data_source" ;
    rdfs:subClassOf biolink:ResourceRoleEnum,
        linkml:PermissibleValue .

<https://w3id.org/biolink/vocab/ResponseEnum#negative> a owl:Class ;
    rdfs:label "negative" ;
    rdfs:subClassOf biolink:ResponseEnum,
        linkml:PermissibleValue ;
    skos:definition "A negative response to a treatment or intervention" .

<https://w3id.org/biolink/vocab/ResponseEnum#therapeutic_response> a owl:Class ;
    rdfs:label "therapeutic_response" ;
    rdfs:subClassOf biolink:ResponseEnum,
        linkml:PermissibleValue ;
    skos:definition "A positive response to a treatment or intervention" .

<https://w3id.org/biolink/vocab/ResponseTargetEnum#cell%20line> a owl:Class ;
    rdfs:label "cell line" ;
    rdfs:subClassOf biolink:ResponseTargetEnum,
        linkml:PermissibleValue ;
    skos:definition "A cell line that is the target of a treatment or intervention" .

<https://w3id.org/biolink/vocab/ResponseTargetEnum#cohort> a owl:Class ;
    rdfs:label "cohort" ;
    rdfs:subClassOf biolink:ResponseTargetEnum,
        linkml:PermissibleValue ;
    skos:definition "A group of individuals that are the target of a treatment or intervention" .

<https://w3id.org/biolink/vocab/ResponseTargetEnum#individual> a owl:Class ;
    rdfs:label "individual" ;
    rdfs:subClassOf biolink:ResponseTargetEnum,
        linkml:PermissibleValue ;
    skos:definition "An individual that is the target of a treatment or intervention" .

<https://w3id.org/biolink/vocab/ResponseTargetEnum#sample> a owl:Class ;
    rdfs:label "sample" ;
    rdfs:subClassOf biolink:ResponseTargetEnum,
        linkml:PermissibleValue ;
    skos:definition "A biological materialsample that is the target of a treatment or intervention" .

biolink:SequenceEnum a owl:Class ;
    rdfs:label "SequenceEnum" ;
    rdfs:subClassOf linkml:EnumDefinition ;
    owl:unionOf ( <https://w3id.org/biolink/vocab/SequenceEnum#na> <https://w3id.org/biolink/vocab/SequenceEnum#aa> ) ;
    skos:definition "type of sequence" ;
    skos:inScheme biolink: ;
    linkml:permissible_values <https://w3id.org/biolink/vocab/SequenceEnum#aa>,
        <https://w3id.org/biolink/vocab/SequenceEnum#na> .

<https://w3id.org/biolink/vocab/SequenceEnum#aa> a owl:Class ;
    rdfs:label "aa" ;
    rdfs:subClassOf biolink:SequenceEnum,
        linkml:PermissibleValue ;
    skos:definition "amino acid" .

<https://w3id.org/biolink/vocab/SequenceEnum#na> a owl:Class ;
    rdfs:label "na" ;
    rdfs:subClassOf biolink:SequenceEnum,
        linkml:PermissibleValue ;
    skos:definition "nucleic acid" .

biolink:SequenceVariantModulatesTreatmentAssociation a owl:Class ;
    rdfs:label "sequence variant modulates treatment association" ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:object ],
        [ a owl:Restriction ;
            owl:allValuesFrom biolink:SequenceVariant ;
            owl:onProperty biolink:subject ],
        [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:subject ],
        [ a owl:Restriction ;
            owl:minCardinality 1 ;
            owl:onProperty biolink:subject ],
        [ a owl:Restriction ;
            owl:minCardinality 1 ;
            owl:onProperty biolink:object ],
        [ a owl:Restriction ;
            owl:allValuesFrom biolink:Treatment ;
            owl:onProperty biolink:object ],
        biolink:Association ;
    skos:definition "An association between a sequence variant and a treatment or health intervention. The treatment object itself encompasses both the disease and the drug used." ;
    skos:inScheme biolink: ;
    skos:note "An alternate way to model the same information could be via a qualifier" .

biolink:Serial a owl:Class ;
    rdfs:label "serial" ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:iso_abbreviation ],
        [ a owl:Restriction ;
            owl:minCardinality 0 ;
            owl:onProperty biolink:type ],
        [ a owl:Restriction ;
            owl:allValuesFrom xsd:string ;
            owl:onProperty biolink:id ],
        [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:issue ],
        [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:id ],
        [ a owl:Restriction ;
            owl:minCardinality 0 ;
            owl:onProperty biolink:issue ],
        [ a owl:Restriction ;
            owl:minCardinality 0 ;
            owl:onProperty biolink:volume ],
        [ a owl:Restriction ;
            owl:allValuesFrom xsd:string ;
            owl:onProperty biolink:volume ],
        [ a owl:Restriction ;
            owl:minCardinality 1 ;
            owl:onProperty biolink:id ],
        [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:volume ],
        [ a owl:Restriction ;
            owl:allValuesFrom xsd:string ;
            owl:onProperty biolink:issue ],
        [ a owl:Restriction ;
            owl:allValuesFrom xsd:string ;
            owl:onProperty biolink:type ],
        [ a owl:Restriction ;
            owl:minCardinality 0 ;
            owl:onProperty biolink:iso_abbreviation ],
        [ a owl:Restriction ;
            owl:allValuesFrom xsd:string ;
            owl:onProperty biolink:iso_abbreviation ],
        biolink:Publication ;
    skos:altLabel "journal" ;
    skos:definition "This class may rarely be instantiated except if use cases of a given knowledge graph support its utility." ;
    skos:inScheme biolink: .

biolink:SiRNA a owl:Class ;
    rdfs:label "siRNA" ;
    rdfs:subClassOf biolink:NoncodingRNAProduct ;
    skos:altLabel "RNAi",
        "small interfering RNA" ;
    skos:definition "A small RNA molecule that is the product of a longer exogenous or endogenous dsRNA, which is either a bimolecular duplex or very long hairpin, processed (via the Dicer pathway) such that numerous siRNAs accumulate from both strands of the dsRNA. SRNAs trigger the cleavage of their target molecules." ;
    skos:exactMatch <http://purl.obolibrary.org/obo/SO_0000646>,
        WIKIDATA:Q203221 ;
    skos:inScheme biolink: .

biolink:SmallMolecule a owl:Class ;
    rdfs:label "small molecule" ;
    rdfs:subClassOf biolink:MolecularEntity ;
    skos:altLabel "chemical substance" ;
    skos:definition "A small molecule entity is a molecular entity characterized by availability in small-molecule databases of SMILES, InChI, IUPAC, or other unambiguous representation of its precise chemical structure; for convenience of representation, any valid chemical representation is included, even if it is not strictly molecular (e.g., sodium ion)." ;
    skos:inScheme biolink: ;
    skos:narrowMatch STY:T109,
        STY:T110,
        STY:T111,
        STY:T115,
        STY:T118,
        STY:T119,
        STY:T124,
        STY:T125,
        STY:T127,
        STY:T196,
        STY:T197,
        <http://purl.obolibrary.org/obo/CHEBI_59999>,
        bioschemas:ChemicalSubstance .

biolink:Snv a owl:Class ;
    rdfs:label "snv" ;
    rdfs:subClassOf biolink:SequenceVariant ;
    skos:altLabel "single nucleotide polymorphism",
        "single nucleotide variant",
        "snp" ;
    skos:definition "SNVs are single nucleotide positions in genomic DNA at which different sequence alternatives exist" ;
    skos:exactMatch <http://purl.obolibrary.org/obo/SO_0001483> ;
    skos:inScheme biolink: .

biolink:SocioeconomicExposure a owl:Class ;
    rdfs:label "socioeconomic exposure" ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:minCardinality 1 ;
            owl:onProperty biolink:has_attribute ],
        [ a owl:Restriction ;
            owl:allValuesFrom biolink:SocioeconomicAttribute ;
            owl:onProperty biolink:has_attribute ],
        biolink:ExposureEvent ;
    skos:definition "A socioeconomic exposure is a factor relating to social and financial status of an affected individual." ;
    skos:inScheme biolink: .

biolink:SpecificityQuantifier a owl:Class ;
    rdfs:label "specificity quantifier" ;
    rdfs:subClassOf biolink:RelationshipQuantifier ;
    skos:definition "A relationship quantifier that measures the specificity of a relationship, such as the proportion of true negatives correctly identified in a diagnostic or association context." ;
    skos:inScheme biolink: .

<https://w3id.org/biolink/vocab/StatisticalSignificanceQualifierEnum#not_significant> a owl:Class ;
    rdfs:label "not_significant" ;
    rdfs:subClassOf biolink:StatisticalSignificanceQualifierEnum,
        linkml:PermissibleValue ;
    skos:definition "A significance band denoting that the association does not meet the conventional threshold (significance statistic above 0.05), such that there is insufficient evidence to rule out the null hypothesis of no association." .

<https://w3id.org/biolink/vocab/StatisticalSignificanceQualifierEnum#significant> a owl:Class ;
    rdfs:label "significant" ;
    rdfs:subClassOf biolink:StatisticalSignificanceQualifierEnum,
        linkml:PermissibleValue ;
    skos:definition "A significance band denoting that the association meets the standard conventional threshold (significance statistic at or below alpha = 0.05), such that, under the null hypothesis, an effect at least this large would be expected in no more than about one in twenty comparable studies." .

<https://w3id.org/biolink/vocab/StatisticalSignificanceQualifierEnum#strongly_significant> a owl:Class ;
    rdfs:label "strongly_significant" ;
    rdfs:subClassOf biolink:StatisticalSignificanceQualifierEnum,
        linkml:PermissibleValue ;
    skos:definition "A significance band denoting that the association meets a stringent conventional threshold (significance statistic at or below 0.01)." .

<https://w3id.org/biolink/vocab/StatisticalSignificanceQualifierEnum#suggestive> a owl:Class ;
    rdfs:label "suggestive" ;
    rdfs:subClassOf biolink:StatisticalSignificanceQualifierEnum,
        linkml:PermissibleValue ;
    skos:definition "A significance band denoting a borderline result (significance statistic above 0.05 but at or below roughly 0.10, sometimes extended to 0.20 in fields such as genetics) that is suggestive of, but does not conclusively support, an association." .

<https://w3id.org/biolink/vocab/StatisticalSignificanceQualifierEnum#very_strongly_significant> a owl:Class ;
    rdfs:label "very_strongly_significant" ;
    rdfs:subClassOf biolink:StatisticalSignificanceQualifierEnum,
        linkml:PermissibleValue ;
    skos:definition "A significance band denoting that the association meets the most stringent conventional threshold (significance statistic at or below 0.001), such that, under the null hypothesis of no association, an effect at least this large would be expected in no more than about one in a thousand comparable studies." .

<https://w3id.org/biolink/vocab/StrandEnum#%2B> a owl:Class ;
    rdfs:label "+" ;
    rdfs:subClassOf biolink:StrandEnum,
        linkml:PermissibleValue ;
    skos:definition "Positive" .

<https://w3id.org/biolink/vocab/StrandEnum#%3F> a owl:Class ;
    rdfs:label "?" ;
    rdfs:subClassOf biolink:StrandEnum,
        linkml:PermissibleValue ;
    skos:definition "Unknown" .

<https://w3id.org/biolink/vocab/StrandEnum#-> a owl:Class ;
    rdfs:label "-" ;
    rdfs:subClassOf biolink:StrandEnum,
        linkml:PermissibleValue ;
    skos:definition "Negative" .

<https://w3id.org/biolink/vocab/StrandEnum#.> a owl:Class ;
    rdfs:label "." ;
    rdfs:subClassOf biolink:StrandEnum,
        linkml:PermissibleValue ;
    skos:definition "Unstranded" .

biolink:TaxonToTaxonAssociation a owl:Class ;
    rdfs:label "taxon to taxon association" ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:object ],
        [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:subject ],
        [ a owl:Restriction ;
            owl:minCardinality 1 ;
            owl:onProperty biolink:object ],
        [ a owl:Restriction ;
            owl:allValuesFrom biolink:OrganismTaxon ;
            owl:onProperty biolink:object ],
        [ a owl:Restriction ;
            owl:allValuesFrom biolink:OrganismTaxon ;
            owl:onProperty biolink:subject ],
        [ a owl:Restriction ;
            owl:minCardinality 1 ;
            owl:onProperty biolink:subject ],
        biolink:Association ;
    skos:definition "An association between two organism taxa, capturing ecological or evolutionary relationships between the taxa (e.g., a host-pathogen relationship or shared habitat)." ;
    skos:inScheme biolink: .

biolink:TaxonomicRank a owl:Class ;
    rdfs:label "taxonomic rank" ;
    rdfs:subClassOf biolink:OntologyClass ;
    skos:definition "A descriptor for the rank within a taxonomic classification. Example instance: TAXRANK:0000017 (kingdom)" ;
    skos:inScheme biolink: ;
    skos:mappingRelation WIKIDATA:Q427626 .

biolink:TranscriptToGeneRelationship a owl:Class ;
    rdfs:label "transcript to gene relationship" ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:minCardinality 1 ;
            owl:onProperty biolink:subject ],
        [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:object ],
        [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:subject ],
        [ a owl:Restriction ;
            owl:allValuesFrom biolink:Gene ;
            owl:onProperty biolink:object ],
        [ a owl:Restriction ;
            owl:minCardinality 1 ;
            owl:onProperty biolink:object ],
        [ a owl:Restriction ;
            owl:allValuesFrom biolink:Transcript ;
            owl:onProperty biolink:subject ],
        biolink:SequenceFeatureRelationship ;
    skos:definition "A gene is a collection of transcripts" ;
    skos:inScheme biolink: .

biolink:TranscriptionFactorBindingSite a owl:Class ;
    rdfs:label "transcription factor binding site" ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:onProperty linkml:mixins ;
            owl:someValuesFrom biolink:GenomicEntity ],
        [ a owl:Restriction ;
            owl:onProperty linkml:mixins ;
            owl:someValuesFrom biolink:ChemicalEntityOrGeneOrGeneProduct ],
        [ a owl:Restriction ;
            owl:onProperty linkml:mixins ;
            owl:someValuesFrom biolink:OntologyClass ],
        [ a owl:Restriction ;
            owl:onProperty linkml:mixins ;
            owl:someValuesFrom biolink:PhysicalEssence ],
        biolink:RegulatoryRegion ;
    skos:altLabel "binding site",
        "tf binding site" ;
    skos:definition "A region (or regions) of the genome that contains a region of DNA known or predicted to bind a protein that modulates gene transcription" ;
    skos:exactMatch <http://purl.obolibrary.org/obo/SO_0000235> ;
    skos:inScheme biolink: .

<https://w3id.org/biolink/vocab/TreatmentOutcomeEnum#deteriorated> a owl:Class ;
    rdfs:label "deteriorated" ;
    rdfs:subClassOf biolink:TreatmentOutcomeEnum,
        linkml:PermissibleValue ;
    skos:definition "Worsening of the condition following treatment." ;
    skos:exactMatch <http://purl.obolibrary.org/obo/NCIT_C25751> ;
    skos:narrowMatch <http://purl.obolibrary.org/obo/NCIT_C35571> .

<https://w3id.org/biolink/vocab/TreatmentOutcomeEnum#died> a owl:Class ;
    rdfs:label "died" ;
    rdfs:subClassOf biolink:TreatmentOutcomeEnum,
        linkml:PermissibleValue ;
    skos:definition "Death following treatment." ;
    skos:exactMatch <http://purl.obolibrary.org/obo/NCIT_C28554> .

<https://w3id.org/biolink/vocab/TreatmentOutcomeEnum#fully_recovered> a owl:Class ;
    rdfs:label "fully_recovered" ;
    rdfs:subClassOf biolink:TreatmentOutcomeEnum,
        linkml:PermissibleValue ;
    skos:definition "Complete recovery following treatment; free of symptoms with no lasting health problems." ;
    skos:exactMatch <http://purl.obolibrary.org/obo/NCIT_C82467> ;
    skos:narrowMatch <http://purl.obolibrary.org/obo/NCIT_C4870> .

<https://w3id.org/biolink/vocab/TreatmentOutcomeEnum#improved> a owl:Class ;
    rdfs:label "improved" ;
    rdfs:subClassOf biolink:TreatmentOutcomeEnum,
        linkml:PermissibleValue ;
    skos:definition "Partial improvement following treatment." ;
    skos:exactMatch <http://purl.obolibrary.org/obo/NCIT_C125459> ;
    skos:narrowMatch <http://purl.obolibrary.org/obo/NCIT_C18058> .

<https://w3id.org/biolink/vocab/TreatmentOutcomeEnum#unchanged> a owl:Class ;
    rdfs:label "unchanged" ;
    rdfs:subClassOf biolink:TreatmentOutcomeEnum,
        linkml:PermissibleValue ;
    skos:definition "No change in the condition following treatment." ;
    skos:exactMatch <http://purl.obolibrary.org/obo/NCIT_C71687> ;
    skos:narrowMatch <http://purl.obolibrary.org/obo/NCIT_C18213> .

<https://w3id.org/biolink/vocab/TreatmentOutcomeEnum#unknown> a owl:Class ;
    rdfs:label "unknown" ;
    rdfs:subClassOf biolink:TreatmentOutcomeEnum,
        linkml:PermissibleValue ;
    skos:definition "Treatment outcome is unknown." ;
    skos:exactMatch <http://purl.obolibrary.org/obo/NCIT_C17998> .

biolink:VariantAsAModelOfDiseaseAssociation a owl:Class ;
    rdfs:label "variant as a model of disease association" ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:subject ],
        [ a owl:Restriction ;
            owl:onProperty linkml:mixins ;
            owl:someValuesFrom biolink:ModelToDiseaseAssociationMixin ],
        [ a owl:Restriction ;
            owl:allValuesFrom biolink:SequenceVariant ;
            owl:onProperty biolink:subject ],
        [ a owl:Restriction ;
            owl:onProperty linkml:mixins ;
            owl:someValuesFrom biolink:EntityToDiseaseAssociationMixin ],
        [ a owl:Restriction ;
            owl:minCardinality 1 ;
            owl:onProperty biolink:subject ],
        biolink:VariantToDiseaseAssociation ;
    skos:definition "An association in which a sequence variant serves as a model of a disease, recapitulating features relevant for studying the disease outside of a patient who carries it." ;
    skos:inScheme biolink: .

biolink:VariantToGeneExpressionAssociation a owl:Class ;
    rdfs:label "variant to gene expression association" ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:predicate ],
        [ a owl:Restriction ;
            owl:onProperty linkml:mixins ;
            owl:someValuesFrom biolink:GeneExpressionMixin ],
        [ a owl:Restriction ;
            owl:minCardinality 1 ;
            owl:onProperty biolink:predicate ],
        [ a owl:Restriction ;
            owl:allValuesFrom xsd:string ;
            owl:onProperty biolink:predicate ],
        biolink:VariantToGeneAssociation ;
    skos:definition "An association between a variant and expression of a gene (i.e. e-QTL)" ;
    skos:inScheme biolink: .

biolink:VariantToPhenotypicFeatureAssociation a owl:Class ;
    rdfs:label "variant to phenotypic feature association" ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:onProperty linkml:mixins ;
            owl:someValuesFrom biolink:EntityToPhenotypicFeatureAssociationMixin ],
        [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:subject ],
        [ a owl:Restriction ;
            owl:allValuesFrom biolink:SequenceVariant ;
            owl:onProperty biolink:subject ],
        [ a owl:Restriction ;
            owl:onProperty linkml:mixins ;
            owl:someValuesFrom biolink:VariantToEntityAssociationMixin ],
        [ a owl:Restriction ;
            owl:minCardinality 1 ;
            owl:onProperty biolink:subject ],
        biolink:Association ;
    skos:definition "An association between a sequence variant and a phenotypic feature, in which the allele state of the variant is linked to the manifestation of the phenotype." ;
    skos:inScheme biolink: .

biolink:VariantToPopulationAssociation a owl:Class ;
    rdfs:label "variant to population association" ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:has_quotient ],
        [ a owl:Restriction ;
            owl:allValuesFrom biolink:SequenceVariant ;
            owl:onProperty biolink:subject ],
        [ a owl:Restriction ;
            owl:onProperty linkml:mixins ;
            owl:someValuesFrom biolink:VariantToEntityAssociationMixin ],
        [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:object ],
        [ a owl:Restriction ;
            owl:minCardinality 1 ;
            owl:onProperty biolink:subject ],
        [ a owl:Restriction ;
            owl:minCardinality 1 ;
            owl:onProperty biolink:object ],
        [ a owl:Restriction ;
            owl:minCardinality 0 ;
            owl:onProperty biolink:has_count ],
        [ a owl:Restriction ;
            owl:onProperty linkml:mixins ;
            owl:someValuesFrom biolink:FrequencyQuantifier ],
        [ a owl:Restriction ;
            owl:allValuesFrom xsd:string ;
            owl:onProperty biolink:has_total ],
        [ a owl:Restriction ;
            owl:allValuesFrom xsd:string ;
            owl:onProperty biolink:has_count ],
        [ a owl:Restriction ;
            owl:allValuesFrom biolink:PopulationOfIndividualOrganisms ;
            owl:onProperty biolink:object ],
        [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:subject ],
        [ a owl:Restriction ;
            owl:minCardinality 0 ;
            owl:onProperty biolink:has_quotient ],
        [ a owl:Restriction ;
            owl:onProperty linkml:mixins ;
            owl:someValuesFrom biolink:FrequencyQualifierMixin ],
        [ a owl:Restriction ;
            owl:minCardinality 0 ;
            owl:onProperty biolink:has_total ],
        [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:has_count ],
        [ a owl:Restriction ;
            owl:allValuesFrom xsd:string ;
            owl:onProperty biolink:has_quotient ],
        [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:has_total ],
        biolink:Association ;
    skos:definition "An association between a variant and a population, where the variant has particular frequency in the population" ;
    skos:inScheme biolink: .

biolink:Vertebrate a owl:Class ;
    rdfs:label "vertebrate" ;
    rdfs:subClassOf biolink:CellularOrganism ;
    skos:exactMatch STY:T010,
        <http://purl.obolibrary.org/obo/NCBITaxon_7742>,
        <http://purl.obolibrary.org/obo/OMIT_0015545> ;
    skos:inScheme biolink: ;
    skos:relatedMatch <http://purl.obolibrary.org/obo/NCBITaxon_2662825> .

biolink:WebPage a owl:Class ;
    rdfs:label "web page" ;
    rdfs:subClassOf biolink:Publication ;
    skos:definition "a document that is published according to World Wide Web standards, which may incorporate text, graphics, sound, and/or other features." ;
    skos:exactMatch NCIT-OBO:C142749,
        fabio:WebPage,
        SIO:000302 ;
    skos:inScheme biolink: .

biolink:actively_involved_in a owl:ObjectProperty ;
    rdfs:label "actively involved in" ;
    rdfs:domain biolink:NamedThing ;
    rdfs:range biolink:BiologicalProcessOrActivity ;
    rdfs:subPropertyOf biolink:participates_in ;
    skos:altLabel "involved in" ;
    skos:definition "holds between a continuant and a process or function, where the continuant actively contributes to part or all of the process or function it realizes" ;
    skos:exactMatch RO:0002331 ;
    skos:inScheme biolink: ;
    skos:narrowMatch RO:0002503,
        NBO-PROPERTY:by_means,
        ORDO:Orphanet_317348,
        ORDO:Orphanet_317349,
        ORDO:Orphanet_327767 ;
    biolink:canonical_predicate true .

biolink:affiliation a owl:DatatypeProperty ;
    rdfs:label "affiliation" ;
    rdfs:domain biolink:Agent ;
    rdfs:range xsd:anyURI ;
    rdfs:subPropertyOf biolink:node_property ;
    skos:definition "a professional relationship between one provider (often a person) within another provider (often an organization). Target provider identity should be specified by a CURIE. Providers may have multiple affiliations." ;
    skos:inScheme biolink: .

biolink:aggregator_knowledge_source a owl:DatatypeProperty ;
    rdfs:label "aggregator knowledge source" ;
    rdfs:subPropertyOf biolink:knowledge_source ;
    skos:definition "An intermediate aggregator resource from which knowledge expressed in an Association was retrieved downstream of the original source, on its path to its current serialized form." ;
    skos:editorialNote "For example, in this Feature Variable Association Edge generated by the Exposure Agent’s ICEES KP, through statistical analysis of clinical and environmental data supplied by the UNC Clinical Data Warehouse, the Edge is passed to the Ranking Agent’s ARAGORN ARA, and then on to the ARS. The retrieval path for this Edge is as follows: ARS--retrieved_from-->  ARAGORN  --retrieved_from-->   ICEES --supporting_data_from-->  UNC Data Warehouse This example illustrates how to represent the source provenance of KP-generated knowledge, including the source of data from which the knowledge was derived. The \"primary knowledge source\" for this edge is \"infores:icees-asthma\". A \"supporting data source\" for this KP- generated knowledge is \"infores:unc-cdw-health.\"  The \"aggregator knowledge source\" for this data is \"infores:aragorn-ara\"" ;
    skos:inScheme biolink: .

biolink:aspect_qualifier a owl:ObjectProperty ;
    rdfs:label "aspect qualifier" ;
    rdfs:range biolink:GeneOrGeneProductOrChemicalEntityAspectEnum ;
    rdfs:subPropertyOf biolink:qualifier ;
    skos:definition "Composes with the core concept to describe new concepts of a different ontological type. e.g. a process in which the core concept participates, a function/activity/role held by the core concept, or a characteristic/quality that inheres in the core concept.  The purpose of the aspect slot is to indicate what aspect is being affected in an 'affects' association." ;
    skos:editorialNote "for good examples of aspects in the gene-> chemical space, please see the GeneOrGeneProductOrChemicalEntityAspectEnum (below) which lists many aspects that can be used to qualify the gene making the full subject a different ontological type. the qualifier ‘expression’ combines with a core concept of ‘Gene X’ to express the composed concept ‘expression of Gene X’ (Gene → Biological Process) the qualifier ‘exposure’ combines with a core concept of ‘Chemical X’ to express the composed concept ‘exposure to Chemical X’ (Chemical → Exposure Process) the qualifier ‘activity’ combines with a core concept of ‘PPARG’ to express the concept ‘activity of PPARG’ (Gene → function/activity) the qualifier ‘emergency Department Visit’ combines with a core concept of ‘Disease X’ to express the concept ‘Emergency Department visits for Disease X’ (Disease → Clinical Event) the qualifier ‘infection’ combines with a core concept of ‘Giardia’ to express the concept ‘Infection with Giardia’ (Taxon → Biological / Pathological Process) the qualifier ‘severity’ combines with a core concept of ‘DILI’ to express the concept ‘the severity level of DILI’ (Disease → (intrinsic) Characteristic/Quality) the qualifier ‘abundance’ combines with a core concept of ‘BRCA2’ to express the concept ‘abundance of BRCA2’ (Gene → (extrinsic) characteristic/quality)" ;
    skos:inScheme biolink: .

biolink:authors a owl:ObjectProperty ;
    rdfs:label "authors" ;
    rdfs:domain biolink:Publication ;
    rdfs:range biolink:Agent ;
    rdfs:subPropertyOf biolink:node_property ;
    skos:definition "connects an publication to the list of authors who contributed to the publication. This property should be a comma-delimited list of author names. It is recommended that an author's name be formatted as \"surname, firstname initial.\".   Note that this property is a node annotation expressing the citation list of authorship which might typically otherwise be more completely documented in biolink:PublicationToProviderAssociation defined edges which point to full details about an author and possibly, some qualifiers which clarify the specific status of a given author in the publication." ;
    skos:inScheme biolink: .

biolink:available_from a owl:ObjectProperty ;
    rdfs:label "available from" ;
    rdfs:range biolink:DrugAvailabilityEnum ;
    rdfs:subPropertyOf biolink:node_property ;
    skos:definition "The regulatory or commercial availability channel through which a drug or chemical entity can be obtained, drawn from DrugAvailabilityEnum." ;
    skos:inScheme biolink: .

biolink:base_coordinate a owl:DatatypeProperty ;
    rdfs:label "base coordinate" ;
    rdfs:range xsd:integer ;
    rdfs:subPropertyOf biolink:sequence_localization_attribute ;
    skos:altLabel "fully-closed",
        "one-based" ;
    skos:definition "A position in the base coordinate system.  Base coordinates start at position 1 instead of position 0." ;
    skos:inScheme biolink: .

biolink:catalyst_qualifier a owl:ObjectProperty ;
    rdfs:label "catalyst qualifier" ;
    rdfs:range biolink:MacromolecularMachineMixin ;
    rdfs:subPropertyOf biolink:association_slot ;
    skos:definition "a qualifier that connects an association between two causally connected entities (for example, two chemical entities, or a chemical entity in that changes location) and the gene product, gene, or complex that enables or catalyzes the change." ;
    skos:inScheme biolink: .

biolink:clinical_trial_age_stage a owl:ObjectProperty ;
    rdfs:label "clinical trial age stage" ;
    rdfs:domain biolink:ClinicalTrial ;
    rdfs:range biolink:ClinicalTrialAgeStageEnum ;
    rdfs:subPropertyOf biolink:node_property ;
    skos:definition "The age stage of a clinical trial as determined by clinicaltrials.gov (adult, child, older adult)" ;
    skos:inScheme biolink: .

biolink:clinical_trial_conditions a owl:ObjectProperty ;
    rdfs:label "clinical trial conditions" ;
    rdfs:domain biolink:ClinicalTrial ;
    rdfs:range biolink:DiseaseOrPhenotypicFeature ;
    rdfs:subPropertyOf biolink:node_property ;
    skos:definition "connects a clinical trial to one or more conditions being studied in the trial" ;
    skos:inScheme biolink: .

biolink:clinical_trial_interventions a owl:ObjectProperty ;
    rdfs:label "clinical trial interventions" ;
    rdfs:domain biolink:ClinicalTrial ;
    rdfs:range biolink:ClinicalIntervention ;
    rdfs:subPropertyOf biolink:node_property ;
    skos:definition "connects a clinical trial to one or more interventions being tested in the trial" ;
    skos:inScheme biolink: .

biolink:contributes_to a owl:DatatypeProperty ;
    rdfs:label "contributes to" ;
    rdfs:subPropertyOf biolink:related_to_at_instance_level ;
    skos:closeMatch <http://purl.obolibrary.org/obo/IDO_0000664> ;
    skos:definition "holds between two entities where the occurrence, existence, or activity of one contributes to the occurrence or generation of the other" ;
    skos:exactMatch RO:0002326 ;
    skos:inScheme biolink: ;
    skos:narrowMatch CTD:marker_mechanism,
        <http://purl.obolibrary.org/obo/MONDO_predisposes_towards>,
        RO:0002255,
        RO:0003304 ;
    biolink:canonical_predicate true .

biolink:derivative_qualifier a owl:DatatypeProperty ;
    rdfs:label "derivative qualifier" ;
    rdfs:subPropertyOf biolink:qualifier ;
    skos:definition "A qualifier that composes with a core subject/object  concept to describe something that is derived from the core concept.  For example, the qualifier ‘metabolite’ combines with a ‘Chemical X’ core concept to express the composed concept ‘a metabolite of Chemical X’." ;
    skos:inScheme biolink: .

biolink:derives_from a owl:DatatypeProperty ;
    rdfs:label "derives from" ;
    rdfs:subPropertyOf biolink:related_to_at_instance_level ;
    skos:definition "holds between two distinct material entities, the new entity and the old entity, in which the new entity begins to exist when the old entity ceases to exist, and the new entity inherits the significant portion of the matter of the old entity" ;
    skos:exactMatch FMA:derives_from,
        RO:0001000,
        DOID-PROPERTY:derives_from ;
    skos:inScheme biolink: ;
    skos:narrowMatch <http://purl.obolibrary.org/obo/CHEBI_has_functional_parent>,
        <http://purl.obolibrary.org/obo/SNOMED_has_specimen_source_topography> ;
    biolink:canonical_predicate true .

biolink:direction_qualifier a owl:DatatypeProperty ;
    rdfs:label "direction qualifier" ;
    rdfs:subPropertyOf biolink:qualifier ;
    skos:definition "Composes with the core concept (+ aspect if provided) to describe a change in its direction or degree." ;
    skos:editorialNote "the qualifier ‘increased’ combines with a core concept of ‘Gene X’ and an aspect of ‘expression’ to express the composed concept ‘increased expression of Gene X’ the qualifier ‘decreased’ combines with a core concept of ‘Protein X’ and an aspect of ‘abundance’ to express the composed concept ‘decreased abundance of Protein X’" ;
    skos:inScheme biolink: .

biolink:equivalent_identifiers a owl:DatatypeProperty ;
    rdfs:label "equivalent identifiers" ;
    rdfs:range xsd:anyURI ;
    rdfs:seeAlso biolink:synonyms,
        biolink:xref ;
    skos:definition "A set of identifiers that are considered equivalent to the primary identifier of the entity. This attribute is used to represent a collection of identifiers that are considered equivalent to the primary identifier of an entity. These equivalent identifiers may come from different databases, ontologies, or naming conventions, but they all refer to the same underlying concept or entity. This attribute is particularly useful in data integration and interoperability scenarios, where it is important to recognize and link different representations of the same entity across various sources." ;
    skos:inScheme <https://w3id.org/biolink/biolink-model/attributes> .

biolink:form_or_variant_qualifier a owl:DatatypeProperty ;
    rdfs:label "form or variant qualifier" ;
    rdfs:subPropertyOf biolink:qualifier ;
    skos:definition "A qualifier that composes with a core subject/object concept to define a specific type, variant, alternative version of this concept. The composed concept remains a subtype or instance of the core concept. For example, the qualifier ‘mutation’ combines with the core concept ‘Gene X’ to express the compose concept ‘a mutation of Gene X’." ;
    skos:editorialNote "please see the ChemicalOrGeneOrGeneProductFormOrVariantEnum (below) for examples of 'form or variant qualifier' terms in the gene->chemical association space. the qualifier ‘mutation’ combines with the core concept ‘Gene X’ to express the compose concept ‘Mutated forms of Gene X’. the qualifier ‘late stage’ combines with a core concept of ‘Disease X’ to express the  more specific concept ‘Late Stage forms of Disease X’ the qualifier ‘recombinant’ combines with a core concept of ‘FLT1 Gene’ to express the composed concept ‘Recombinant forms of the FLT1 gene’ the qualifier ‘chemical analog’ combines with a core concept of ‘Ditiocarb’ to express the composed concept ‘analog forms of Ditiocarb’" ;
    skos:inScheme biolink: .

biolink:genetically_associated_with a owl:DatatypeProperty,
        owl:SymmetricProperty ;
    rdfs:label "genetically associated with" ;
    rdfs:subPropertyOf biolink:associated_with ;
    skos:definition "A statistical association, observed in genetic studies, between a genetic entity such as a gene, locus, or variant and a phenotype, disease, or trait." ;
    skos:exactMatch WIKIDATA_PROPERTY:P2293 ;
    skos:inScheme biolink: ;
    biolink:canonical_predicate true ;
    biolink:description "Co-occurrence of a certain allele of a genetic marker and the phenotype of interest in the same individuals at above-chance level" .

biolink:genetically_interacts_with a owl:ObjectProperty,
        owl:SymmetricProperty ;
    rdfs:label "genetically interacts with" ;
    rdfs:domain biolink:Gene ;
    rdfs:range biolink:Gene ;
    rdfs:subPropertyOf biolink:interacts_with ;
    skos:definition "holds between two genes whose phenotypic effects are dependent on each other in some way - such that their combined phenotypic effects are the result of some interaction between the activity of their gene products. Examples include epistasis and synthetic lethality." ;
    skos:exactMatch RO:0002435 ;
    skos:inScheme biolink: ;
    biolink:canonical_predicate true .

biolink:has_device a owl:ObjectProperty ;
    rdfs:label "has device" ;
    rdfs:range biolink:Device ;
    rdfs:subPropertyOf biolink:node_property ;
    skos:definition "connects an entity to one or more (medical) devices" ;
    skos:inScheme biolink: .

biolink:has_drug a owl:ObjectProperty ;
    rdfs:label "has drug" ;
    rdfs:range biolink:Drug ;
    rdfs:subPropertyOf biolink:node_property ;
    skos:definition "connects an entity to one or more drugs" ;
    skos:inScheme biolink: .

biolink:has_evidence a owl:ObjectProperty ;
    rdfs:label "has evidence" ;
    rdfs:range biolink:InformationContentEntity ;
    rdfs:subPropertyOf biolink:association_slot ;
    skos:definition "Connects an association to detailed information providing supporting evidence." ;
    skos:exactMatch RO:0002558 ;
    skos:inScheme biolink: .

biolink:has_evidence_of_type a owl:ObjectProperty ;
    rdfs:label "has evidence of type" ;
    rdfs:range biolink:EvidenceType ;
    rdfs:subPropertyOf biolink:association_slot ;
    skos:definition "Connects an association to an evidence type ontology term. Generally represents terms from the ECO ontology." ;
    skos:inScheme biolink: .

biolink:has_food_component a owl:ObjectProperty ;
    rdfs:label "has food component" ;
    rdfs:domain biolink:ChemicalEntity ;
    rdfs:range biolink:ChemicalEntity ;
    rdfs:subPropertyOf biolink:has_part ;
    skos:definition "holds between food and one or more chemical entities composing it, irrespective of nutritional value (i.e. could also be a contaminant or additive)" ;
    skos:inScheme biolink: ;
    biolink:canonical_predicate true .

biolink:has_gene a owl:ObjectProperty ;
    rdfs:label "has gene" ;
    rdfs:range biolink:Gene ;
    rdfs:subPropertyOf biolink:has_gene_or_gene_product ;
    skos:definition "connects an entity associated with one or more genes" ;
    skos:inScheme biolink: .

biolink:has_procedure a owl:ObjectProperty ;
    rdfs:label "has procedure" ;
    rdfs:range biolink:Procedure ;
    rdfs:subPropertyOf biolink:node_property ;
    skos:definition "connects an entity to one or more (medical) procedures" ;
    skos:inScheme biolink: .

biolink:has_studies a owl:ObjectProperty ;
    rdfs:label "has studies" ;
    rdfs:range biolink:Study ;
    rdfs:subPropertyOf biolink:node_property ;
    skos:closeMatch OBAN:has_study_id ;
    skos:definition "Studies which are components of a given node entity (e.g. a publication)" ;
    skos:inScheme biolink: .

biolink:has_study_results a owl:ObjectProperty ;
    rdfs:label "has study results" ;
    rdfs:domain biolink:Study ;
    rdfs:range biolink:StudyResult ;
    rdfs:subPropertyOf biolink:association_slot ;
    skos:definition "Connects an study to instances of its study result" ;
    skos:inScheme biolink: .

biolink:has_supporting_studies a owl:ObjectProperty ;
    rdfs:label "has supporting studies" ;
    rdfs:range biolink:Study ;
    rdfs:subPropertyOf biolink:association_slot ;
    skos:closeMatch OBAN:has_study_id ;
    skos:definition "Studies that produced information used as evidence to generate the knowledge expressed in an Association." ;
    skos:inScheme biolink: .

biolink:has_upstream_actor a owl:ObjectProperty ;
    rdfs:label "has upstream actor" ;
    rdfs:domain biolink:BiologicalProcess ;
    rdfs:range biolink:GeneOrGeneProduct ;
    rdfs:subPropertyOf biolink:has_upstream_or_within_actor ;
    owl:inverseOf biolink:acts_upstream_of ;
    skos:inScheme biolink: .

biolink:hgvs_nomenclature a owl:DatatypeProperty ;
    rdfs:label "hgvs nomenclature" ;
    rdfs:domain biolink:SequenceVariant ;
    rdfs:subPropertyOf biolink:node_property ;
    skos:definition "HGVS syntax refers to the specific rules and conventions used by the Human Variant Nomenclature Committee to describe the location and change in DNA, RNA, and protein sequence variants.  This slot is used to capture all the different forms of HGVS nomenclature that may be used to describe a sequence variant, including genomic, transcript, and protein HGVS expressions/nomenclatures and is thus multivalued." ;
    skos:inScheme biolink: ;
    skos:note "For more information, please see: https://hgvs-nomenclature.org/stable/background/simple/ and examples: https://hgvs-nomenclature.org/stable/recommendations/summary/." .

biolink:in_preclinical_trials_for a owl:ObjectProperty ;
    rdfs:label "in preclinical trials for" ;
    rdfs:domain biolink:ChemicalOrDrugOrTreatment ;
    rdfs:range biolink:DiseaseOrPhenotypicFeature ;
    rdfs:subPropertyOf biolink:studied_to_treat,
        biolink:treats_or_applied_or_studied_to_treat ;
    skos:definition "Holds between an  substance, procedure, or activity and a medical condition, and reports that a pre-clinical study has been performed specifically to test the potential of the  substance, procedure, or activity to treat the medical condition  (i.e. to ameliorate, stabilize, or cure the condition, or to delay, prevent, or reduce the risk of it manifesting in the first place)." ;
    skos:inScheme biolink: ;
    biolink:canonical_predicate true .

biolink:interbase_coordinate a owl:DatatypeProperty ;
    rdfs:label "interbase coordinate" ;
    rdfs:range xsd:integer ;
    rdfs:subPropertyOf biolink:sequence_localization_attribute ;
    skos:altLabel "half-open",
        "space-based",
        "zero-based" ;
    skos:definition "A position in interbase coordinates. Interbase coordinates start at position 0 instead of position 1. This is applied to a sequence localization edge." ;
    skos:inScheme biolink: .

biolink:keywords a owl:DatatypeProperty ;
    rdfs:label "keywords" ;
    rdfs:domain biolink:Publication ;
    rdfs:subPropertyOf biolink:node_property ;
    skos:definition "keywords tagging a publication" ;
    skos:inScheme biolink: .

biolink:likelihood_associated_with a owl:DatatypeProperty ;
    rdfs:label "likelihood associated with" ;
    rdfs:subPropertyOf biolink:associated_with ;
    owl:inverseOf biolink:associated_with_likelihood_of ;
    skos:inScheme biolink: .

biolink:location_of a owl:ObjectProperty ;
    rdfs:label "location of" ;
    rdfs:domain biolink:NamedThing ;
    rdfs:range biolink:NamedThing ;
    rdfs:subPropertyOf biolink:related_to_at_instance_level ;
    owl:inverseOf biolink:located_in ;
    skos:altLabel "site of" ;
    skos:definition "holds between material entity or site and a material entity that is located within it (but not considered a part of it)" ;
    skos:exactMatch FMA:location_of,
        RO:0001015,
        SEMMEDDB:LOCATION_OF,
        WIKIDATA_PROPERTY:P276 ;
    skos:inScheme biolink: ;
    skos:narrowMatch <http://purl.obolibrary.org/obo/NCIT_Anatomic_Structure_Has_Location_Role>,
        <http://purl.obolibrary.org/obo/SNOMED_inherent_location_of> .

biolink:log_odds_ratio_95_ci a owl:DatatypeProperty ;
    rdfs:label "log odds ratio 95 ci" ;
    rdfs:range xsd:float ;
    rdfs:subPropertyOf biolink:node_property ;
    skos:definition "The ninety-five percent confidence range in which the true log odds ratio for the sample population falls. To calculate the 95% confidence interval (CI) for a log odds ratio (a pair of numbers), you need the standard error (SE) of the log odds ratio.  This interval helps you understand the precision of your estimate and whether the association is statistically significant." ;
    skos:inScheme biolink: .

biolink:manifestation_of a owl:ObjectProperty ;
    rdfs:label "manifestation of" ;
    rdfs:range biolink:Disease ;
    rdfs:subPropertyOf biolink:related_to_at_instance_level ;
    skos:broadMatch WIKIDATA_PROPERTY:P1557 ;
    skos:definition "that part of a phenomenon which is directly observable or visibly expressed, or which gives evidence to the underlying process; used in SemMedDB for linking things like dysfunctions and processes to some disease or syndrome" ;
    skos:exactMatch <http://purl.obolibrary.org/obo/OMIM_manifestation_of>,
        SEMMEDDB:MANIFESTATION_OF ;
    skos:inScheme biolink: ;
    skos:narrowMatch <http://purl.obolibrary.org/obo/SNOMED_has_definitional_manifestation> ;
    biolink:canonical_predicate true .

biolink:mesh_terms a owl:DatatypeProperty ;
    rdfs:label "mesh terms" ;
    rdfs:domain biolink:Publication ;
    rdfs:range xsd:anyURI ;
    rdfs:subPropertyOf biolink:node_property ;
    skos:definition "mesh terms tagging a publication" ;
    skos:exactMatch dcid:MeSHTerm ;
    skos:inScheme biolink: .

biolink:object_category_closure a owl:ObjectProperty ;
    rdfs:label "object category closure" ;
    rdfs:domain biolink:Association ;
    rdfs:range biolink:OntologyClass ;
    rdfs:subPropertyOf biolink:association_slot ;
    skos:definition "Used to hold the object category closure of an association. This is a denormalized field used primarily in the SQL serialization of a knowledge graph via KGX." ;
    skos:inScheme biolink: ;
    biolink:denormalized true .

biolink:object_closure a owl:DatatypeProperty ;
    rdfs:label "object closure" ;
    rdfs:domain biolink:Association ;
    rdfs:subPropertyOf biolink:association_slot ;
    skos:definition "Used to hold the object closure of an association. This is a denormalized field used primarily in the SQL serialization of a knowledge graph via KGX." ;
    skos:inScheme biolink: ;
    biolink:denormalized true .

biolink:object_label_closure a owl:DatatypeProperty ;
    rdfs:label "object label closure" ;
    rdfs:domain biolink:Association ;
    rdfs:range xsd:string ;
    rdfs:subPropertyOf biolink:association_slot ;
    skos:definition "Used to hold the object label closure of an association. This is a denormalized field used primarily in the SQL serialization of a knowledge graph via KGX." ;
    skos:inScheme biolink: ;
    biolink:denormalized true .

biolink:object_location_in_text a owl:DatatypeProperty ;
    rdfs:label "object location in text" ;
    rdfs:range xsd:integer ;
    rdfs:subPropertyOf biolink:node_property ;
    skos:definition "Character offsets for the text span(s) in the supporting text corresponding to the object concept of the extracted assertion" ;
    skos:inScheme biolink: .

biolink:overlaps a owl:DatatypeProperty,
        owl:SymmetricProperty ;
    rdfs:label "overlaps" ;
    rdfs:subPropertyOf biolink:related_to_at_instance_level ;
    skos:definition "holds between entities that overlap in their extents (materials or processes)" ;
    skos:exactMatch RO:0002131 ;
    skos:inScheme biolink: ;
    skos:narrowMatch <http://purl.obolibrary.org/obo/BSPO_0005001>,
        RO:0002100,
        RO:0002102,
        RO:0002433,
        CHEMBL.MECHANISM:overlaps_with ;
    biolink:canonical_predicate true .

biolink:pages a owl:DatatypeProperty ;
    rdfs:label "pages" ;
    rdfs:domain biolink:Publication ;
    rdfs:subPropertyOf biolink:node_property ;
    skos:definition "page number of source referenced for statement or publication" ;
    skos:exactMatch WIKIDATA_PROPERTY:P304 ;
    skos:inScheme biolink: .

biolink:part_qualifier a owl:DatatypeProperty ;
    rdfs:label "part qualifier" ;
    rdfs:subPropertyOf biolink:qualifier ;
    skos:definition "defines a specific part/component of the core concept (used in cases there this specific part has no IRI we can use to directly represent it)." ;
    skos:inScheme biolink: .

biolink:physically_interacts_with a owl:DatatypeProperty,
        owl:SymmetricProperty ;
    rdfs:label "physically interacts with" ;
    rdfs:subPropertyOf biolink:interacts_with ;
    skos:broadMatch WIKIDATA_PROPERTY:P129 ;
    skos:definition "holds between two entities that make physical contact as part of some interaction. does not imply a causal relationship." ;
    skos:inScheme biolink: ;
    skos:narrowMatch <http://identifiers.org/drugbank/drug-interaction>,
        FMA:adheres_to,
        <http://purl.obolibrary.org/obo/NCIT_A7>,
        <http://purl.obolibrary.org/obo/PR_non-covalently_bound_to> ;
    biolink:canonical_predicate true .

biolink:predicate_mappings a owl:ObjectProperty ;
    rdfs:label "predicate mappings" ;
    rdfs:range biolink:PredicateMapping ;
    skos:definition "A collection of relationships that are not used in biolink, but have biolink patterns that can be used to replace them.  This is a temporary slot to help with the transition to the fully qualified predicate model in Biolink3." ;
    skos:inScheme biolink: .

biolink:provided_by a owl:DatatypeProperty ;
    rdfs:label "provided by" ;
    rdfs:subPropertyOf biolink:node_property ;
    skos:definition "The value in this node property represents the knowledge provider that created or assembled the node and all of its attributes.  Used internally to represent how a particular node made its way into a knowledge provider or graph." ;
    skos:inScheme biolink: .

biolink:publication_type a owl:DatatypeProperty ;
    rdfs:label "publication type" ;
    skos:definition "Ontology term for publication type may be drawn from Dublin Core types (https://www.dublincore.org/specifications/dublin-core/dcmi-type-vocabulary/), FRBR-aligned Bibliographic Ontology (https://sparontologies.github.io/fabio/current/fabio.html), the MESH publication types (https://www.nlm.nih.gov/mesh/pubtypes.html), the Confederation of Open Access Repositories (COAR) Controlled Vocabulary for Resource Type Genres (http://vocabularies.coar-repositories.org/documentation/resource_types/), Wikidata (https://www.wikidata.org/wiki/Wikidata:Publication_types), or equivalent publication type ontology. When a given publication type ontology term is used within a given knowledge graph, then the CURIE identified term must be documented in the graph as a concept node of biolink:category biolink:OntologyClass." ;
    skos:inScheme biolink: .

biolink:publications a owl:ObjectProperty ;
    rdfs:label "publications" ;
    rdfs:range biolink:Publication ;
    rdfs:subPropertyOf biolink:association_slot ;
    skos:altLabel "supporting documents",
        "supporting publications" ;
    skos:definition "One or more publications that report the statement expressed in an Association, or provide information used as evidence supporting this statement." ;
    skos:inScheme biolink: ;
    skos:note "The notion of a ‘Publication’ is considered broadly to include any document made available for public consumption. It covers journal issues, individual articles, and books - and also things like article pre-prints, white papers, patents, drug labels, web pages, protocol documents, etc." .

biolink:regulatory_approvals a owl:DatatypeProperty ;
    rdfs:label "regulatory approvals" ;
    rdfs:range xsd:string ;
    skos:definition "Numbers or identifiers issued by regulatory agencies that identify specific drug applications or marketing authorizations. Values are application-number provenance and are not guaranteed to be verified identifiers from any particular agency; they may include FDA application numbers (for example, as seen with ranitidine having both ANADA200536 and ANDA200536) as well as identifiers from other regulatory agencies such as EMA marketing authorizations. Each drug can have multiple approval numbers." ;
    skos:inScheme biolink: .

biolink:response_associated_with a owl:DatatypeProperty ;
    rdfs:label "response associated with" ;
    rdfs:subPropertyOf biolink:associated_with ;
    owl:inverseOf biolink:associated_with_response_to ;
    skos:inScheme biolink: .

biolink:retrieval_source_ids a owl:ObjectProperty ;
    rdfs:label "retrieval source ids" ;
    rdfs:range biolink:RetrievalSource ;
    skos:definition "A list of retrieval sources that served as a source of knowledge expressed in an Edge, or a source of data used to generate this knowledge." ;
    skos:inScheme biolink: .

biolink:routes_of_delivery a owl:ObjectProperty ;
    rdfs:label "routes of delivery" ;
    rdfs:range biolink:DrugDeliveryEnum ;
    skos:definition "the method or process of administering a pharmaceutical compound to achieve a therapeutic effect in humans or animals." ;
    skos:inScheme biolink: .

biolink:sensitivity_affected_by a owl:ObjectProperty ;
    rdfs:label "sensitivity affected by" ;
    rdfs:domain biolink:ChemicalEntityOrGeneOrGeneProduct ;
    rdfs:range biolink:ChemicalEntityOrGeneOrGeneProduct ;
    rdfs:subPropertyOf biolink:related_to_at_instance_level ;
    owl:inverseOf biolink:affects_sensitivity_to ;
    skos:inScheme biolink: .

biolink:similar_to a owl:DatatypeProperty,
        owl:SymmetricProperty ;
    rdfs:label "similar to" ;
    rdfs:subPropertyOf biolink:related_to_at_instance_level ;
    skos:definition "holds between an entity and some other entity with similar features." ;
    skos:exactMatch RO:HOM0000000,
        <http://purl.obolibrary.org/obo/SO_similar_to> ;
    skos:inScheme biolink: ;
    biolink:canonical_predicate true .

biolink:source_record_urls a owl:DatatypeProperty ;
    rdfs:label "source record urls" ;
    rdfs:domain biolink:RetrievalSource ;
    rdfs:range xsd:anyURI ;
    rdfs:subPropertyOf biolink:node_property ;
    skos:definition "A URL linking to a specific web page or document provided by the source, that contains a record of the knowledge expressed in the Edge. If the knowledge is contained in more than one web page on an Information Resource's site, urls MAY be provided for each." ;
    skos:inScheme biolink: .

biolink:sources a owl:ObjectProperty ;
    rdfs:label "sources" ;
    rdfs:range biolink:RetrievalSource ;
    rdfs:subPropertyOf biolink:association_slot ;
    skos:altLabel "source retrieval provenance" ;
    skos:definition "A set of RetrievalSources, which traces where the statement expressed in an Association came from. For example, the provenance of a Gene-Chemical Edge might be traced through the Translator Resource that provided it (e.g. MolePro) to one or more intermediate aggregator resources (e.g. ChEMBL), and finally to the resource that originally created/curated it (e.g. ClinicalTrials.org)." ;
    skos:inScheme biolink: ;
    skos:note "Note that source retrieval provenance concerns the mechanical retrieval and transformation of data between web accessible information systems. It does not trace the source of knowledge back to specific publications or data sets. And it is not concerned with the reasoning, inference or analysis activities that generate knowledge in the first place (this is instead covered by 'knowledge level' and 'agent type' properties)." .

biolink:specialization_qualifier a owl:DatatypeProperty ;
    rdfs:label "specialization qualifier" ;
    rdfs:subPropertyOf biolink:qualifier ;
    skos:definition "A qualifier that composes with a core subject/object concept to define a more specific version of the subject concept, specifically using an ontology term that is not a subclass or descendant of the core concept and in the vast majority of cases, is of a different ontological namespace than the category or namespace of the subject identifier." ;
    skos:inScheme biolink: .

biolink:study_method_types a owl:DatatypeProperty ;
    rdfs:label "study method types" ;
    rdfs:range xsd:anyURI ;
    rdfs:subPropertyOf biolink:study_metadata ;
    skos:definition "Type(s) of methods that were applied in a study (e.g. a type of experimental assay, or statistical calculation, or computational analysis)." ;
    skos:inScheme biolink: .

biolink:subject_category_closure a owl:ObjectProperty ;
    rdfs:label "subject category closure" ;
    rdfs:domain biolink:Association ;
    rdfs:range biolink:OntologyClass ;
    rdfs:subPropertyOf biolink:association_slot ;
    skos:definition "Used to hold the subject category closure of an association. This is a denormalized field used primarily in the SQL serialization of a knowledge graph via KGX." ;
    skos:inScheme biolink: ;
    biolink:denormalized true .

biolink:subject_closure a owl:DatatypeProperty ;
    rdfs:label "subject closure" ;
    rdfs:domain biolink:Association ;
    rdfs:subPropertyOf biolink:association_slot ;
    skos:definition "Used to hold the subject closure of an association. This is a denormalized field used primarily in the SQL serialization of a knowledge graph via KGX." ;
    skos:inScheme biolink: ;
    biolink:denormalized true .

biolink:subject_label_closure a owl:DatatypeProperty ;
    rdfs:label "subject label closure" ;
    rdfs:domain biolink:Association ;
    rdfs:range xsd:string ;
    rdfs:subPropertyOf biolink:association_slot ;
    skos:definition "Used to hold the subject label closure of an association. This is a denormalized field used primarily in the SQL serialization of a knowledge graph via KGX." ;
    skos:inScheme biolink: ;
    biolink:denormalized true .

biolink:subject_location_in_text a owl:DatatypeProperty ;
    rdfs:label "subject location in text" ;
    rdfs:range xsd:integer ;
    rdfs:subPropertyOf biolink:node_property ;
    skos:definition "Character offsets for the text span(s) in the supporting text corresponding to the subject concept of the extracted assertion." ;
    skos:inScheme biolink: .

biolink:subsets a owl:DatatypeProperty ;
    rdfs:label "subsets" ;
    rdfs:domain biolink:NamedThing ;
    rdfs:range xsd:string ;
    rdfs:subPropertyOf biolink:node_property ;
    skos:definition "The set of ontology subsets a term belongs to (e.g. GO slim subsets, MONDO rare disease subset). Carries the values of `oboInOwl:inSubset` annotations from source ontologies through to downstream knowledge graphs." ;
    skos:exactMatch OIO:inSubset ;
    skos:inScheme biolink: .

biolink:temporally_related_to a owl:ObjectProperty,
        owl:SymmetricProperty ;
    rdfs:label "temporally related to" ;
    rdfs:domain biolink:Occurrent ;
    rdfs:range biolink:Occurrent ;
    rdfs:subPropertyOf biolink:related_to_at_instance_level ;
    skos:definition "holds between two entities with a temporal relationship" ;
    skos:exactMatch <http://purl.obolibrary.org/obo/SNOMED_temporally_related_to> ;
    skos:inScheme biolink: ;
    skos:narrowMatch RO:0002082,
        RO:0002083,
        RO:0002092,
        RO:0002093,
        RO:0002223,
        RO:0002224,
        RO:0002229,
        RO:0002230,
        RO:0002488,
        RO:0002489,
        RO:0002492,
        RO:0002493,
        RO:0002496,
        RO:0002497 ;
    biolink:canonical_predicate true .

biolink:treated_in_studies_by a owl:ObjectProperty ;
    rdfs:label "treated in studies by" ;
    rdfs:domain biolink:DiseaseOrPhenotypicFeature ;
    rdfs:range biolink:ChemicalOrDrugOrTreatment ;
    rdfs:subPropertyOf biolink:subject_of_treatment_application_or_study_for_treatment_by,
        biolink:treated_by ;
    owl:inverseOf biolink:studied_to_treat ;
    skos:inScheme biolink: .

biolink:treatment_outcome a owl:ObjectProperty ;
    rdfs:label "treatment outcome" ;
    rdfs:range biolink:TreatmentOutcomeEnum ;
    rdfs:subPropertyOf biolink:association_slot ;
    skos:definition "The outcome of treating a disease or phenotypic feature with a chemical entity." ;
    skos:inScheme biolink: .

biolink:upstream_resource_ids a owl:DatatypeProperty ;
    rdfs:label "upstream resource ids" ;
    rdfs:domain biolink:RetrievalSource ;
    rdfs:range xsd:anyURI ;
    rdfs:subPropertyOf biolink:node_property ;
    skos:definition "An upstream InformationResource from which the resource being described directly retrieved a record of the knowledge expressed in the Edge, or data used to generate this knowledge. This is an array because there are cases where a merged Edge holds knowledge that was retrieved from multiple sources." ;
    skos:inScheme biolink: .

biolink:Activity a owl:Class ;
    rdfs:label "activity" ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:onProperty linkml:mixins ;
            owl:someValuesFrom biolink:ActivityAndBehavior ],
        biolink:NamedThing ;
    skos:definition "An activity is something that occurs over a period of time and acts upon or with entities; it may include consuming, processing, transforming, modifying, relocating, using, or generating entities." ;
    skos:exactMatch STY:T052,
        <http://purl.obolibrary.org/obo/NCIT_C43431>,
        prov:Activity ;
    skos:inScheme biolink: ;
    skos:narrowMatch STY:T056,
        STY:T057,
        STY:T058,
        STY:T062,
        STY:T064,
        STY:T065,
        STY:T066 .

biolink:AdministrativeEntity a owl:Class ;
    rdfs:label "administrative entity" ;
    rdfs:subClassOf biolink:Agent,
        biolink:NamedThing ;
    skos:definition "An entity that is the byproduct of an administrative process." ;
    skos:inScheme biolink: .

biolink:AnatomicalEntityHasPartAnatomicalEntityAssociation a owl:Class ;
    rdfs:label "anatomical entity has part anatomical entity association" ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:minCardinality 1 ;
            owl:onProperty biolink:object ],
        [ a owl:Restriction ;
            owl:allValuesFrom xsd:string ;
            owl:onProperty biolink:predicate ],
        [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:object ],
        [ a owl:Restriction ;
            owl:allValuesFrom biolink:AnatomicalEntity ;
            owl:onProperty biolink:subject ],
        [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:predicate ],
        [ a owl:Restriction ;
            owl:allValuesFrom biolink:AnatomicalEntity ;
            owl:onProperty biolink:object ],
        [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:subject ],
        [ a owl:Restriction ;
            owl:minCardinality 1 ;
            owl:onProperty biolink:subject ],
        [ a owl:Restriction ;
            owl:minCardinality 1 ;
            owl:onProperty biolink:predicate ],
        biolink:AnatomicalEntityToAnatomicalEntityAssociation ;
    skos:definition "A relationship between two anatomical entities where the relationship is mereological, i.e the two entities are related by parthood, that is, the subject is has the object entity as a part (the expected predicate is \"biolink:has_part\" or suitable predicate slots inheriting from it, i.e., \"biolink:has_plasma_membrane_part\",  \"biolink:has_variant_part\", etc.). This includes relationships between cells and cellular components, between issues and cells, whole organisms and tissues." ;
    skos:inScheme biolink: .

biolink:AnatomicalEntityPartOfAnatomicalEntityAssociation a owl:Class ;
    rdfs:label "anatomical entity part of anatomical entity association" ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:minCardinality 1 ;
            owl:onProperty biolink:predicate ],
        [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:object ],
        [ a owl:Restriction ;
            owl:minCardinality 1 ;
            owl:onProperty biolink:subject ],
        [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:subject ],
        [ a owl:Restriction ;
            owl:minCardinality 1 ;
            owl:onProperty biolink:object ],
        [ a owl:Restriction ;
            owl:allValuesFrom xsd:string ;
            owl:onProperty biolink:predicate ],
        [ a owl:Restriction ;
            owl:allValuesFrom biolink:AnatomicalEntity ;
            owl:onProperty biolink:subject ],
        [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:predicate ],
        [ a owl:Restriction ;
            owl:allValuesFrom biolink:AnatomicalEntity ;
            owl:onProperty biolink:object ],
        biolink:AnatomicalEntityToAnatomicalEntityAssociation ;
    skos:definition "A relationship between two anatomical entities where the relationship is mereological, i.e the two entities are related by parthood, that is, the subject is a part of the object entity (the expected predicate is \"biolink:part_of\" or suitable predicate slots inheriting from it, i.e., \"biolink:plasma_membrane_part_of\",  \"biolink:variant_part_of\", etc.). This includes relationships between cellular components and cells, between cells and tissues, tissues and whole organisms." ;
    skos:inScheme biolink: .

biolink:AnatomicalEntityToAnatomicalEntityOntogenicAssociation a owl:Class ;
    rdfs:label "anatomical entity to anatomical entity ontogenic association" ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:minCardinality 1 ;
            owl:onProperty biolink:predicate ],
        [ a owl:Restriction ;
            owl:minCardinality 1 ;
            owl:onProperty biolink:object ],
        [ a owl:Restriction ;
            owl:allValuesFrom xsd:string ;
            owl:onProperty biolink:predicate ],
        [ a owl:Restriction ;
            owl:minCardinality 1 ;
            owl:onProperty biolink:subject ],
        [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:predicate ],
        [ a owl:Restriction ;
            owl:allValuesFrom biolink:AnatomicalEntity ;
            owl:onProperty biolink:subject ],
        [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:subject ],
        [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:object ],
        [ a owl:Restriction ;
            owl:allValuesFrom biolink:AnatomicalEntity ;
            owl:onProperty biolink:object ],
        biolink:AnatomicalEntityToAnatomicalEntityAssociation ;
    skos:definition "A relationship between two anatomical entities where the relationship is ontogenic, i.e. the two entities are related by development. A number of different relationship types can be used to specify the precise nature of the relationship." ;
    skos:inScheme biolink: .

biolink:Article a owl:Class ;
    rdfs:label "article" ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:iso_abbreviation ],
        [ a owl:Restriction ;
            owl:minCardinality 1 ;
            owl:onProperty biolink:published_in ],
        [ a owl:Restriction ;
            owl:minCardinality 0 ;
            owl:onProperty biolink:iso_abbreviation ],
        [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:published_in ],
        [ a owl:Restriction ;
            owl:minCardinality 0 ;
            owl:onProperty biolink:issue ],
        [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:volume ],
        [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:issue ],
        [ a owl:Restriction ;
            owl:allValuesFrom xsd:string ;
            owl:onProperty biolink:volume ],
        [ a owl:Restriction ;
            owl:allValuesFrom xsd:string ;
            owl:onProperty biolink:issue ],
        [ a owl:Restriction ;
            owl:allValuesFrom xsd:anyURI ;
            owl:onProperty biolink:published_in ],
        [ a owl:Restriction ;
            owl:minCardinality 0 ;
            owl:onProperty biolink:volume ],
        [ a owl:Restriction ;
            owl:allValuesFrom xsd:string ;
            owl:onProperty biolink:iso_abbreviation ],
        biolink:Publication ;
    skos:definition "a piece of writing on a particular topic presented as a stand-alone section of a larger publication" ;
    skos:exactMatch fabio:article,
        SIO:000154 ;
    skos:inScheme biolink: .

biolink:Bacterium a owl:Class ;
    rdfs:label "bacterium" ;
    rdfs:subClassOf biolink:OrganismalEntity ;
    skos:definition "A member of a group of unicellular microorganisms lacking a nuclear membrane, that reproduce by binary fission and are often motile." ;
    skos:exactMatch STY:T007,
        <http://purl.obolibrary.org/obo/NCBITaxon_1869227> ;
    skos:inScheme biolink: .

biolink:Behavior a owl:Class ;
    rdfs:label "behavior" ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:onProperty linkml:mixins ;
            owl:someValuesFrom biolink:OntologyClass ],
        [ a owl:Restriction ;
            owl:onProperty linkml:mixins ;
            owl:someValuesFrom biolink:ActivityAndBehavior ],
        biolink:BiologicalProcess ;
    skos:definition "The internally coordinated responses (actions or inactions) of organisms (individuals or groups) to internal or external stimuli, via a mechanism that involves nervous system activity." ;
    skos:exactMatch STY:T053,
        <http://purl.obolibrary.org/obo/GO_0007610> ;
    skos:inScheme biolink: ;
    skos:narrowMatch STY:T041,
        STY:T054,
        STY:T055 .

biolink:BehavioralFeature a owl:Class ;
    rdfs:label "behavioral feature" ;
    rdfs:subClassOf biolink:PhenotypicFeature ;
    skos:definition "A phenotypic feature which is behavioral in nature." ;
    skos:exactMatch <http://purl.obolibrary.org/obo/NBO_0000243> ;
    skos:inScheme biolink: .

biolink:BookChapter a owl:Class ;
    rdfs:label "book chapter" ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:chapter ],
        [ a owl:Restriction ;
            owl:minCardinality 1 ;
            owl:onProperty biolink:published_in ],
        [ a owl:Restriction ;
            owl:allValuesFrom xsd:string ;
            owl:onProperty biolink:chapter ],
        [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:published_in ],
        [ a owl:Restriction ;
            owl:allValuesFrom xsd:anyURI ;
            owl:onProperty biolink:published_in ],
        [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:volume ],
        [ a owl:Restriction ;
            owl:minCardinality 0 ;
            owl:onProperty biolink:chapter ],
        [ a owl:Restriction ;
            owl:allValuesFrom xsd:string ;
            owl:onProperty biolink:volume ],
        [ a owl:Restriction ;
            owl:minCardinality 0 ;
            owl:onProperty biolink:volume ],
        biolink:Publication ;
    skos:definition "A section of a book that forms a discrete unit of a larger published work and may be independently authored or cited." ;
    skos:inScheme biolink: .

biolink:Case a owl:Class ;
    rdfs:label "case" ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:onProperty linkml:mixins ;
            owl:someValuesFrom biolink:SubjectOfInvestigation ],
        [ a owl:Restriction ;
            owl:allValuesFrom biolink:BiologicalSex ;
            owl:onProperty biolink:has_biological_sex ],
        [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:has_biological_sex ],
        [ a owl:Restriction ;
            owl:minCardinality 0 ;
            owl:onProperty biolink:has_biological_sex ],
        biolink:IndividualOrganism ;
    skos:altLabel "patient",
        "proband" ;
    skos:definition "An individual (human) organism that has a patient role in some clinical context." ;
    skos:inScheme biolink: .

<https://w3id.org/biolink/vocab/CausalMechanismQualifierEnum#allosteric_modulation> a owl:Class ;
    rdfs:label "allosteric_modulation" ;
    rdfs:subClassOf biolink:CausalMechanismQualifierEnum,
        <https://w3id.org/biolink/vocab/CausalMechanismQualifierEnum#modulation> ;
    skos:definition "A modulation mechanism that occurs when a chemical exerts an effect on a protein targets via a different binding site than the natural ('orthosteric') ligand site." .

<https://w3id.org/biolink/vocab/CausalMechanismQualifierEnum#immune_system_modulation> a owl:Class ;
    rdfs:label "immune_system_modulation" ;
    rdfs:subClassOf biolink:CausalMechanismQualifierEnum,
        <https://w3id.org/biolink/vocab/CausalMechanismQualifierEnum#modulation> ;
    skos:definition "A modulation mechanism in which the actions of the effector on the immune system ultimately mediate the affects a target." .

<https://w3id.org/biolink/vocab/CausalMechanismQualifierEnum#methylation> a owl:Class ;
    rdfs:label "methylation" ;
    rdfs:subClassOf biolink:CausalMechanismQualifierEnum,
        <https://w3id.org/biolink/vocab/CausalMechanismQualifierEnum#molecular_modification> .

<https://w3id.org/biolink/vocab/CausalMechanismQualifierEnum#mixed_allosteric_modulation> a owl:Class ;
    rdfs:label "mixed_allosteric_modulation" ;
    rdfs:subClassOf biolink:CausalMechanismQualifierEnum,
        <https://w3id.org/biolink/vocab/CausalMechanismQualifierEnum#allosteric_modulation> ;
    skos:definition "An allosteric modulation mechanism that occurs when a chemical may exert an activating effect or an inhibitory effect in different conditions / contexts (e.g. concentration, receptor conformational state, signaling pathway context, receptor subtype, cellular environment)." .

<https://w3id.org/biolink/vocab/CausalMechanismQualifierEnum#noncompetitive_inhibition> a owl:Class ;
    rdfs:label "noncompetitive_inhibition" ;
    rdfs:subClassOf biolink:CausalMechanismQualifierEnum,
        <https://w3id.org/biolink/vocab/CausalMechanismQualifierEnum#inhibition> ;
    skos:definition "An inhibition mechanism in which the effector binds to a target molecule (such as an enzyme) at a site other than the active site, in a way that reduces the activity of the target." .

<https://w3id.org/biolink/vocab/CausalMechanismQualifierEnum#stabilization> a owl:Class ;
    rdfs:label "stabilization" ;
    rdfs:subClassOf biolink:CausalMechanismQualifierEnum,
        <https://w3id.org/biolink/vocab/CausalMechanismQualifierEnum#modulation> ;
    skos:closeMatch CHEMBL.MECHANISM:stabiliser ;
    skos:definition "A modulation mechanism in which the effector increases the conformational stability of a protein or complex." .

biolink:CellLineToDiseaseOrPhenotypicFeatureAssociation a owl:Class ;
    rdfs:label "cell line to disease or phenotypic feature association" ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:allValuesFrom biolink:DiseaseOrPhenotypicFeature ;
            owl:onProperty biolink:subject ],
        [ a owl:Restriction ;
            owl:onProperty linkml:mixins ;
            owl:someValuesFrom biolink:CellLineToEntityAssociationMixin ],
        [ a owl:Restriction ;
            owl:minCardinality 1 ;
            owl:onProperty biolink:subject ],
        [ a owl:Restriction ;
            owl:onProperty linkml:mixins ;
            owl:someValuesFrom biolink:EntityToDiseaseOrPhenotypicFeatureAssociationMixin ],
        [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:subject ],
        biolink:Association ;
    skos:definition "An relationship between a cell line and a disease or a phenotype, where the cell line is derived from an individual with that disease or phenotype." ;
    skos:inScheme biolink: .

biolink:ChemicalAffectsBiologicalEntityAssociation a owl:Class ;
    rdfs:label "chemical affects biological entity association" ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:allValuesFrom biolink:GeneOrGeneProductOrChemicalEntityAspectEnum ;
            owl:onProperty biolink:subject_aspect_qualifier ],
        [ a owl:Restriction ;
            owl:minCardinality 1 ;
            owl:onProperty biolink:object ],
        [ a owl:Restriction ;
            owl:minCardinality 0 ;
            owl:onProperty biolink:object_aspect_qualifier ],
        [ a owl:Restriction ;
            owl:minCardinality 0 ;
            owl:onProperty biolink:species_context_qualifier ],
        [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:subject_derivative_qualifier ],
        [ a owl:Restriction ;
            owl:allValuesFrom biolink:ChemicalEntityDerivativeEnum ;
            owl:onProperty biolink:subject_derivative_qualifier ],
        [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:object_direction_qualifier ],
        [ a owl:Restriction ;
            owl:minCardinality 0 ;
            owl:onProperty biolink:anatomical_context_qualifier ],
        [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:subject_form_or_variant_qualifier ],
        [ a owl:Restriction ;
            owl:allValuesFrom biolink:BiologicalEntity ;
            owl:onProperty biolink:object ],
        [ a owl:Restriction ;
            owl:allValuesFrom biolink:ChemicalOrGeneOrGeneProductFormOrVariantEnum ;
            owl:onProperty biolink:subject_form_or_variant_qualifier ],
        [ a owl:Restriction ;
            owl:minCardinality 0 ;
            owl:onProperty biolink:object_direction_qualifier ],
        [ a owl:Restriction ;
            owl:minCardinality 0 ;
            owl:onProperty biolink:causal_mechanism_qualifier ],
        [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:object ],
        [ a owl:Restriction ;
            owl:allValuesFrom biolink:GeneOrGeneProductOrChemicalPartQualifierEnum ;
            owl:onProperty biolink:object_part_qualifier ],
        [ a owl:Restriction ;
            owl:minCardinality 0 ;
            owl:onProperty biolink:object_form_or_variant_qualifier ],
        [ a owl:Restriction ;
            owl:allValuesFrom biolink:ChemicalOrGeneOrGeneProductFormOrVariantEnum ;
            owl:onProperty biolink:object_form_or_variant_qualifier ],
        [ a owl:Restriction ;
            owl:allValuesFrom xsd:string ;
            owl:onProperty biolink:predicate ],
        [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:subject_direction_qualifier ],
        [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:qualified_predicate ],
        [ a owl:Restriction ;
            owl:allValuesFrom biolink:DirectionQualifierEnum ;
            owl:onProperty biolink:object_direction_qualifier ],
        [ a owl:Restriction ;
            owl:allValuesFrom biolink:AnatomicalEntity ;
            owl:onProperty biolink:object_context_qualifier ],
        [ a owl:Restriction ;
            owl:allValuesFrom biolink:DirectionQualifierEnum ;
            owl:onProperty biolink:subject_direction_qualifier ],
        [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:subject ],
        [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:subject_context_qualifier ],
        [ a owl:Restriction ;
            owl:allValuesFrom biolink:ChemicalEntity ;
            owl:onProperty biolink:subject ],
        [ a owl:Restriction ;
            owl:minCardinality 0 ;
            owl:onProperty biolink:qualified_predicate ],
        [ a owl:Restriction ;
            owl:minCardinality 0 ;
            owl:onProperty biolink:subject_part_qualifier ],
        [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:object_context_qualifier ],
        [ a owl:Restriction ;
            owl:allValuesFrom biolink:AnatomicalEntity ;
            owl:onProperty biolink:subject_context_qualifier ],
        [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:object_aspect_qualifier ],
        [ a owl:Restriction ;
            owl:allValuesFrom biolink:GeneOrGeneProductOrChemicalEntityAspectEnum ;
            owl:onProperty biolink:object_aspect_qualifier ],
        [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:subject_part_qualifier ],
        [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:predicate ],
        [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:subject_aspect_qualifier ],
        [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:object_part_qualifier ],
        [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:object_form_or_variant_qualifier ],
        [ a owl:Restriction ;
            owl:allValuesFrom biolink:OrganismTaxon ;
            owl:onProperty biolink:species_context_qualifier ],
        [ a owl:Restriction ;
            owl:allValuesFrom biolink:AnatomicalEntity ;
            owl:onProperty biolink:anatomical_context_qualifier ],
        [ a owl:Restriction ;
            owl:minCardinality 0 ;
            owl:onProperty biolink:subject_form_or_variant_qualifier ],
        [ a owl:Restriction ;
            owl:minCardinality 0 ;
            owl:onProperty biolink:subject_derivative_qualifier ],
        [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:causal_mechanism_qualifier ],
        [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:species_context_qualifier ],
        [ a owl:Restriction ;
            owl:minCardinality 0 ;
            owl:onProperty biolink:subject_direction_qualifier ],
        [ a owl:Restriction ;
            owl:minCardinality 0 ;
            owl:onProperty biolink:subject_aspect_qualifier ],
        [ a owl:Restriction ;
            owl:minCardinality 1 ;
            owl:onProperty biolink:subject ],
        [ a owl:Restriction ;
            owl:minCardinality 1 ;
            owl:onProperty biolink:predicate ],
        [ a owl:Restriction ;
            owl:allValuesFrom xsd:anyURI ;
            owl:onProperty biolink:qualified_predicate ],
        [ a owl:Restriction ;
            owl:minCardinality 0 ;
            owl:onProperty biolink:object_part_qualifier ],
        [ a owl:Restriction ;
            owl:allValuesFrom biolink:GeneOrGeneProductOrChemicalPartQualifierEnum ;
            owl:onProperty biolink:subject_part_qualifier ],
        [ a owl:Restriction ;
            owl:minCardinality 0 ;
            owl:onProperty biolink:subject_context_qualifier ],
        [ a owl:Restriction ;
            owl:allValuesFrom biolink:CausalMechanismQualifierEnum ;
            owl:onProperty biolink:causal_mechanism_qualifier ],
        [ a owl:Restriction ;
            owl:minCardinality 0 ;
            owl:onProperty biolink:object_context_qualifier ],
        biolink:Association ;
    skos:definition "Describes an effect that a chemical has on a biological entity (e.g. an impact of on its abundance, activity,localization, processing, expression, etc.)" ;
    skos:inScheme biolink: .

biolink:ChemicalEntityToEntityAssociationMixin a owl:Class ;
    rdfs:label "chemical entity to entity association mixin" ;
    rdfs:subClassOf <https://w3id.org/linkml/ClassDefinition#Mixin> ;
    skos:definition "An interaction between a chemical entity and another entity" ;
    skos:inScheme biolink: .

biolink:ChemicalExposure a owl:Class ;
    rdfs:label "chemical exposure" ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:minCardinality 0 ;
            owl:onProperty biolink:has_quantitative_value ],
        [ a owl:Restriction ;
            owl:allValuesFrom biolink:QuantityValue ;
            owl:onProperty biolink:has_quantitative_value ],
        biolink:ExposureEvent ;
    skos:definition "A chemical exposure is an intake of a particular chemical entity." ;
    skos:exactMatch ECTO:9000000,
        SIO:001399 ;
    skos:inScheme biolink: .

<https://w3id.org/biolink/vocab/ChemicalOrGeneOrGeneProductFormOrVariantEnum#polymorphic_form> a owl:Class ;
    rdfs:label "polymorphic_form" ;
    rdfs:subClassOf biolink:ChemicalOrGeneOrGeneProductFormOrVariantEnum,
        <https://w3id.org/biolink/vocab/ChemicalOrGeneOrGeneProductFormOrVariantEnum#genetic_variant_form> .

biolink:ChiSquaredAnalysisResult a owl:Class ;
    rdfs:label "chi squared analysis result" ;
    rdfs:subClassOf biolink:StudyResult ;
    skos:definition "A result of a chi squared analysis." ;
    skos:inScheme biolink: .

<https://w3id.org/biolink/vocab/ClinicalApprovalStatusEnum#approved_for_condition> a owl:Class ;
    rdfs:label "approved_for_condition" ;
    rdfs:subClassOf biolink:ClinicalApprovalStatusEnum,
        linkml:PermissibleValue .

biolink:ClinicalCourse a owl:Class ;
    rdfs:label "clinical course" ;
    rdfs:subClassOf biolink:ClinicalAttribute ;
    skos:definition "The course a disease typically takes from its onset, progression in time, and eventual resolution or death of the affected individual" ;
    skos:exactMatch <http://purl.obolibrary.org/obo/HP_0031797> ;
    skos:inScheme biolink: .

biolink:ClinicalEntity a owl:Class ;
    rdfs:label "clinical entity" ;
    rdfs:subClassOf biolink:NamedThing ;
    skos:definition "Any entity or process that exists in the clinical domain and outside the biological realm. Diseases are placed under biological entities" ;
    skos:inScheme biolink: .

biolink:ClinicalModifier a owl:Class ;
    rdfs:label "clinical modifier" ;
    rdfs:subClassOf biolink:ClinicalAttribute ;
    skos:definition "Used to characterize and specify the phenotypic abnormalities defined in the phenotypic abnormality sub-ontology, with respect to severity, laterality, and other aspects" ;
    skos:inScheme biolink: .

biolink:CommonDataElement a owl:Class ;
    rdfs:label "common data element" ;
    rdfs:subClassOf biolink:InformationContentEntity ;
    skos:closeMatch <http://purl.obolibrary.org/obo/NCIT_C19984> ;
    skos:definition "A Common Data Element (CDE) is a standardized, precisely defined question, paired with a set of allowable responses, used systematically across different sites, studies, or clinical trials to ensure consistent data collection. Multiple CDEs (from one or more Collections) can be curated into Forms. (https://cde.nlm.nih.gov/home)" ;
    skos:inScheme biolink: .

biolink:ConceptCountAnalysisResult a owl:Class ;
    rdfs:label "concept count analysis result" ;
    rdfs:subClassOf biolink:StudyResult ;
    skos:definition "A result of a concept count analysis." ;
    skos:inScheme biolink: .

biolink:ConfidenceLevel a owl:Class ;
    rdfs:label "confidence level" ;
    rdfs:subClassOf biolink:InformationContentEntity ;
    skos:closeMatch <http://purl.obolibrary.org/obo/SEPIO_0000167> ;
    skos:definition "Level of confidence in a statement" ;
    skos:exactMatch <http://purl.obolibrary.org/obo/CIO_0000028>,
        <http://purl.obolibrary.org/obo/SEPIO_0000187> ;
    skos:inScheme biolink: .

<https://w3id.org/biolink/vocab/DirectionQualifierEnum#decreased> a owl:Class ;
    rdfs:label "decreased" ;
    rdfs:subClassOf biolink:DirectionQualifierEnum,
        linkml:PermissibleValue .

<https://w3id.org/biolink/vocab/DirectionQualifierEnum#increased> a owl:Class ;
    rdfs:label "increased" ;
    rdfs:subClassOf biolink:DirectionQualifierEnum,
        linkml:PermissibleValue .

biolink:DiseaseOrPhenotypicFeatureToEntityAssociationMixin a owl:Class ;
    rdfs:label "disease or phenotypic feature to entity association mixin" ;
    rdfs:subClassOf <https://w3id.org/linkml/ClassDefinition#Mixin> ;
    skos:inScheme biolink: .

biolink:DrugExposure a owl:Class ;
    rdfs:label "drug exposure" ;
    rdfs:subClassOf biolink:ChemicalExposure ;
    skos:altLabel "drug dose",
        "drug intake",
        "medication intake" ;
    skos:broadMatch SIO:001005 ;
    skos:definition "A drug exposure is an intake of a particular drug." ;
    skos:exactMatch ECTO:0000509 ;
    skos:inScheme biolink: .

biolink:EnvironmentalExposure a owl:Class ;
    rdfs:label "environmental exposure" ;
    rdfs:subClassOf biolink:ExposureEvent ;
    skos:definition "A environmental exposure is a factor relating to abiotic processes in the environment including sunlight (UV-B), atmospheric (heat, cold, general pollution) and water-born contaminants." ;
    skos:inScheme biolink: .

biolink:Evidence a owl:Class ;
    rdfs:label "evidence" ;
    rdfs:subClassOf biolink:InformationContentEntity ;
    skos:definition "Dereferences detailed evidence that supports an association" ;
    skos:inScheme biolink: .

biolink:FDA_adverse_event_level a owl:ObjectProperty ;
    rdfs:label "FDA adverse event level" ;
    rdfs:range biolink:FDAIDAAdverseEventEnum ;
    rdfs:subPropertyOf biolink:association_slot ;
    skos:definition "The level or severity grade of an adverse event as classified by FDA adverse-event terminology, drawn from FDAIDAAdverseEventEnum; used on adverse-event associations." ;
    skos:inScheme biolink: .

biolink:GeneExpressionMixin a owl:Class ;
    rdfs:label "gene expression mixin" ;
    rdfs:subClassOf <https://w3id.org/linkml/ClassDefinition#Mixin> ;
    skos:definition "Observed gene expression intensity, context (site, stage) and associated phenotypic status within which the expression occurs." ;
    skos:inScheme biolink: .

<https://w3id.org/biolink/vocab/GeneOrGeneProductOrChemicalEntityAspectEnum#cleavage> a owl:Class ;
    rdfs:label "cleavage" ;
    rdfs:subClassOf biolink:GeneOrGeneProductOrChemicalEntityAspectEnum,
        linkml:PermissibleValue .

biolink:Genome a owl:Class ;
    rdfs:label "genome" ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:onProperty linkml:mixins ;
            owl:someValuesFrom biolink:OntologyClass ],
        [ a owl:Restriction ;
            owl:onProperty linkml:mixins ;
            owl:someValuesFrom biolink:PhysicalEssence ],
        [ a owl:Restriction ;
            owl:onProperty linkml:mixins ;
            owl:someValuesFrom biolink:GenomicEntity ],
        biolink:BiologicalEntity ;
    skos:closeMatch dcid:GenomeAssemblyUnit ;
    skos:definition "A genome is the sum of genetic material within a cell or virion." ;
    skos:exactMatch <http://purl.obolibrary.org/obo/SO_0001026>,
        SIO:000984,
        WIKIDATA:Q7020 ;
    skos:inScheme biolink: .

biolink:GenomicSequenceLocalization a owl:Class ;
    rdfs:label "genomic sequence localization" ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:object ],
        [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:phase ],
        [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:start_interbase_coordinate ],
        [ a owl:Restriction ;
            owl:allValuesFrom biolink:NucleicAcidEntity ;
            owl:onProperty biolink:subject ],
        [ a owl:Restriction ;
            owl:minCardinality 1 ;
            owl:onProperty biolink:predicate ],
        [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:end_interbase_coordinate ],
        [ a owl:Restriction ;
            owl:allValuesFrom xsd:string ;
            owl:onProperty biolink:predicate ],
        [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:strand ],
        [ a owl:Restriction ;
            owl:minCardinality 0 ;
            owl:onProperty biolink:phase ],
        [ a owl:Restriction ;
            owl:minCardinality 0 ;
            owl:onProperty biolink:genome_build ],
        [ a owl:Restriction ;
            owl:minCardinality 1 ;
            owl:onProperty biolink:object ],
        [ a owl:Restriction ;
            owl:minCardinality 0 ;
            owl:onProperty biolink:start_interbase_coordinate ],
        [ a owl:Restriction ;
            owl:allValuesFrom biolink:PhaseEnum ;
            owl:onProperty biolink:phase ],
        [ a owl:Restriction ;
            owl:allValuesFrom biolink:StrandEnum ;
            owl:onProperty biolink:genome_build ],
        [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:genome_build ],
        [ a owl:Restriction ;
            owl:allValuesFrom biolink:NucleicAcidEntity ;
            owl:onProperty biolink:object ],
        [ a owl:Restriction ;
            owl:allValuesFrom biolink:StrandEnum ;
            owl:onProperty biolink:strand ],
        [ a owl:Restriction ;
            owl:allValuesFrom xsd:string ;
            owl:onProperty biolink:start_interbase_coordinate ],
        [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:subject ],
        [ a owl:Restriction ;
            owl:minCardinality 0 ;
            owl:onProperty biolink:end_interbase_coordinate ],
        [ a owl:Restriction ;
            owl:minCardinality 0 ;
            owl:onProperty biolink:strand ],
        [ a owl:Restriction ;
            owl:allValuesFrom xsd:string ;
            owl:onProperty biolink:end_interbase_coordinate ],
        [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:predicate ],
        [ a owl:Restriction ;
            owl:minCardinality 1 ;
            owl:onProperty biolink:subject ],
        biolink:SequenceAssociation ;
    skos:broadMatch dcid:Chromosome ;
    skos:definition "A relationship between a sequence feature and a nucleic acid entity it is localized to. The reference entity may be a chromosome, chromosome region or information entity such as a contig." ;
    skos:exactMatch dcid:GenomeAnnotation ;
    skos:inScheme biolink: .

biolink:GenotypeToDiseaseAssociation a owl:Class ;
    rdfs:label "genotype to disease association" ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:allValuesFrom owl:Thing ;
            owl:onProperty biolink:object ],
        [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:predicate ],
        [ a owl:Restriction ;
            owl:minCardinality 1 ;
            owl:onProperty biolink:predicate ],
        [ a owl:Restriction ;
            owl:onProperty linkml:mixins ;
            owl:someValuesFrom biolink:EntityToDiseaseAssociationMixin ],
        [ a owl:Restriction ;
            owl:minCardinality 1 ;
            owl:onProperty biolink:object ],
        [ a owl:Restriction ;
            owl:onProperty linkml:mixins ;
            owl:someValuesFrom biolink:GenotypeToEntityAssociationMixin ],
        [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:subject ],
        [ a owl:Restriction ;
            owl:allValuesFrom xsd:string ;
            owl:onProperty biolink:predicate ],
        [ a owl:Restriction ;
            owl:allValuesFrom owl:Thing ;
            owl:onProperty biolink:subject ],
        [ a owl:Restriction ;
            owl:minCardinality 1 ;
            owl:onProperty biolink:subject ],
        [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:object ],
        biolink:Association ;
    skos:definition "An association between a genotype and a disease, in which the genotype (typically a combination of alleles at one or more loci) is linked to the disease state." ;
    skos:inScheme biolink: ;
    skos:note "TODO decide no how to model pathogenicity" .

biolink:GenotypeToEntityAssociationMixin a owl:Class ;
    rdfs:label "genotype to entity association mixin" ;
    rdfs:subClassOf <https://w3id.org/linkml/ClassDefinition#Mixin> ;
    skos:inScheme biolink: .

biolink:GeographicLocation a owl:Class ;
    rdfs:label "geographic location" ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:minCardinality 0 ;
            owl:onProperty biolink:longitude ],
        [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:latitude ],
        [ a owl:Restriction ;
            owl:allValuesFrom xsd:float ;
            owl:onProperty biolink:longitude ],
        [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:longitude ],
        [ a owl:Restriction ;
            owl:allValuesFrom xsd:float ;
            owl:onProperty biolink:latitude ],
        [ a owl:Restriction ;
            owl:minCardinality 0 ;
            owl:onProperty biolink:latitude ],
        biolink:PlanetaryEntity ;
    skos:definition "a location that can be described in lat/long coordinates" ;
    skos:exactMatch STY:T083,
        UMLSSG:GEOG ;
    skos:inScheme biolink: .

biolink:Haplotype a owl:Class ;
    rdfs:label "haplotype" ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:onProperty linkml:mixins ;
            owl:someValuesFrom biolink:OntologyClass ],
        [ a owl:Restriction ;
            owl:onProperty linkml:mixins ;
            owl:someValuesFrom biolink:PhysicalEssence ],
        [ a owl:Restriction ;
            owl:onProperty linkml:mixins ;
            owl:someValuesFrom biolink:GenomicEntity ],
        biolink:BiologicalEntity ;
    skos:definition "A set of zero or more Alleles on a single instance of a Sequence[VMC]" ;
    skos:exactMatch <http://purl.obolibrary.org/obo/GENO_0000871>,
        <http://purl.obolibrary.org/obo/SO_0001024>,
        VMC:Haplotype ;
    skos:inScheme biolink: .

biolink:IceesStudyResult a owl:Class ;
    rdfs:label "icees study result" ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:chi_squared_dof ],
        [ a owl:Restriction ;
            owl:allValuesFrom xsd:float ;
            owl:onProperty biolink:fisher_exact_odds_ratio ],
        [ a owl:Restriction ;
            owl:minCardinality 0 ;
            owl:onProperty biolink:fisher_exact_p ],
        [ a owl:Restriction ;
            owl:allValuesFrom xsd:integer ;
            owl:onProperty biolink:total_sample_size ],
        [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:total_sample_size ],
        [ a owl:Restriction ;
            owl:allValuesFrom xsd:float ;
            owl:onProperty biolink:log_odds_ratio ],
        [ a owl:Restriction ;
            owl:minCardinality 0 ;
            owl:onProperty biolink:chi_squared_p ],
        [ a owl:Restriction ;
            owl:allValuesFrom xsd:float ;
            owl:onProperty biolink:chi_squared_statistic ],
        [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:fisher_exact_odds_ratio ],
        [ a owl:Restriction ;
            owl:minCardinality 0 ;
            owl:onProperty biolink:fisher_exact_odds_ratio ],
        [ a owl:Restriction ;
            owl:allValuesFrom xsd:integer ;
            owl:onProperty biolink:chi_squared_dof ],
        [ a owl:Restriction ;
            owl:allValuesFrom xsd:float ;
            owl:onProperty biolink:log_odds_ratio_95_ci ],
        [ a owl:Restriction ;
            owl:allValuesFrom xsd:float ;
            owl:onProperty biolink:fisher_exact_p ],
        [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:log_odds_ratio ],
        [ a owl:Restriction ;
            owl:minCardinality 0 ;
            owl:onProperty biolink:chi_squared_dof ],
        [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:fisher_exact_p ],
        [ a owl:Restriction ;
            owl:minCardinality 0 ;
            owl:onProperty biolink:total_sample_size ],
        [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:chi_squared_p ],
        [ a owl:Restriction ;
            owl:allValuesFrom xsd:float ;
            owl:onProperty biolink:chi_squared_p ],
        [ a owl:Restriction ;
            owl:minCardinality 0 ;
            owl:onProperty biolink:log_odds_ratio_95_ci ],
        [ a owl:Restriction ;
            owl:minCardinality 0 ;
            owl:onProperty biolink:log_odds_ratio ],
        [ a owl:Restriction ;
            owl:minCardinality 0 ;
            owl:onProperty biolink:chi_squared_statistic ],
        [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:chi_squared_statistic ],
        biolink:StudyResult ;
    skos:definition "A study result that represents a result, from a supporting Study, which is specifically associated with an Integrated Clinical and Environmental Exposures Service (ICEES) knowledge assertion." ;
    skos:inScheme biolink: .

biolink:LogOddsAnalysisResult a owl:Class ;
    rdfs:label "log odds analysis result" ;
    rdfs:subClassOf biolink:StudyResult ;
    skos:definition "A result of a log odds ratio analysis." ;
    skos:inScheme biolink: .

biolink:MacromolecularComplex a owl:Class ;
    rdfs:label "macromolecular complex" ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:onProperty linkml:mixins ;
            owl:someValuesFrom biolink:MacromolecularMachineMixin ],
        biolink:BiologicalEntity ;
    skos:definition "A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together." ;
    skos:exactMatch <http://purl.obolibrary.org/obo/GO_0032991>,
        WIKIDATA:Q22325163 ;
    skos:inScheme biolink: .

biolink:Mammal a owl:Class ;
    rdfs:label "mammal" ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:onProperty linkml:mixins ;
            owl:someValuesFrom biolink:SubjectOfInvestigation ],
        biolink:CellularOrganism ;
    skos:exactMatch STY:T015,
        <http://purl.obolibrary.org/obo/FOODON_03411134>,
        <http://purl.obolibrary.org/obo/NCBITaxon_40674>,
        <http://purl.obolibrary.org/obo/NCIT_C14234> ;
    skos:inScheme biolink: .

biolink:MolecularMixture a owl:Class ;
    rdfs:label "molecular mixture" ;
    rdfs:subClassOf biolink:ChemicalMixture ;
    skos:definition "A molecular mixture is a chemical mixture composed of two or more molecular entities with known concentration and stoichiometry." ;
    skos:inScheme biolink: .

biolink:NucleicAcidSequenceMotif a owl:Class ;
    rdfs:label "nucleic acid sequence motif" ;
    rdfs:subClassOf biolink:BiologicalEntity ;
    skos:altLabel "consensus sequence" ;
    skos:definition "A linear nucleotide sequence pattern that is widespread and has, or is conjectured to have, a biological significance. consensus sequences." ;
    skos:inScheme biolink: .

biolink:NucleosomeModification a owl:Class ;
    rdfs:label "nucleosome modification" ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:onProperty linkml:mixins ;
            owl:someValuesFrom biolink:GeneProductIsoformMixin ],
        [ a owl:Restriction ;
            owl:onProperty linkml:mixins ;
            owl:someValuesFrom biolink:EpigenomicEntity ],
        [ a owl:Restriction ;
            owl:onProperty linkml:mixins ;
            owl:someValuesFrom biolink:GenomicEntity ],
        biolink:BiologicalEntity ;
    skos:definition "A chemical modification of a histone protein within a nucleosome octomer or a substitution of a histone with a variant histone isoform." ;
    skos:inScheme biolink: .

biolink:ObservedExpectedFrequencyAnalysisResult a owl:Class ;
    rdfs:label "observed expected frequency analysis result" ;
    rdfs:subClassOf biolink:StudyResult ;
    skos:definition "A result of a observed expected frequency analysis." ;
    skos:inScheme biolink: .

biolink:OrganismAttribute a owl:Class ;
    rdfs:label "organism attribute" ;
    rdfs:subClassOf biolink:Attribute ;
    skos:definition "describes a characteristic of an organismal entity." ;
    skos:exactMatch STY:T032 ;
    skos:inScheme biolink: .

biolink:OrganismTaxonToEntityAssociation a owl:Class ;
    rdfs:label "organism taxon to entity association" ;
    rdfs:subClassOf <https://w3id.org/linkml/ClassDefinition#Mixin> ;
    skos:definition "An association between an organism taxon and another entity" ;
    skos:inScheme biolink: .

biolink:OrganismTaxonToOrganismTaxonInteraction a owl:Class ;
    rdfs:label "organism taxon to organism taxon interaction" ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:associated_environmental_context ],
        [ a owl:Restriction ;
            owl:minCardinality 1 ;
            owl:onProperty biolink:subject ],
        [ a owl:Restriction ;
            owl:allValuesFrom biolink:OrganismTaxon ;
            owl:onProperty biolink:object ],
        [ a owl:Restriction ;
            owl:allValuesFrom xsd:string ;
            owl:onProperty biolink:associated_environmental_context ],
        [ a owl:Restriction ;
            owl:minCardinality 1 ;
            owl:onProperty biolink:object ],
        [ a owl:Restriction ;
            owl:allValuesFrom xsd:string ;
            owl:onProperty biolink:predicate ],
        [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:predicate ],
        [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:object ],
        [ a owl:Restriction ;
            owl:minCardinality 0 ;
            owl:onProperty biolink:associated_environmental_context ],
        [ a owl:Restriction ;
            owl:minCardinality 1 ;
            owl:onProperty biolink:predicate ],
        [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:subject ],
        [ a owl:Restriction ;
            owl:allValuesFrom biolink:OrganismTaxon ;
            owl:onProperty biolink:subject ],
        biolink:OrganismTaxonToOrganismTaxonAssociation ;
    skos:definition "An interaction relationship between two taxa. This may be a symbiotic relationship (encompassing mutualism and parasitism), or it may be non-symbiotic. Example: plague transmitted_by flea; cattle domesticated_by Homo sapiens; plague infects Homo sapiens" ;
    skos:inScheme biolink: .

biolink:OrganismTaxonToOrganismTaxonSpecialization a owl:Class ;
    rdfs:label "organism taxon to organism taxon specialization" ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:allValuesFrom biolink:OrganismTaxon ;
            owl:onProperty biolink:subject ],
        [ a owl:Restriction ;
            owl:minCardinality 1 ;
            owl:onProperty biolink:subject ],
        [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:predicate ],
        [ a owl:Restriction ;
            owl:allValuesFrom biolink:OrganismTaxon ;
            owl:onProperty biolink:object ],
        [ a owl:Restriction ;
            owl:minCardinality 1 ;
            owl:onProperty biolink:predicate ],
        [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:object ],
        [ a owl:Restriction ;
            owl:minCardinality 1 ;
            owl:onProperty biolink:object ],
        [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:subject ],
        [ a owl:Restriction ;
            owl:allValuesFrom xsd:string ;
            owl:onProperty biolink:predicate ],
        biolink:OrganismTaxonToOrganismTaxonAssociation ;
    skos:definition "A child-parent relationship between two taxa. For example: Homo sapiens subclass_of Homo" ;
    skos:inScheme biolink: .

biolink:PairwiseGeneToGeneInteraction a owl:Class ;
    rdfs:label "pairwise gene to gene interaction" ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:minCardinality 1 ;
            owl:onProperty biolink:predicate ],
        [ a owl:Restriction ;
            owl:allValuesFrom xsd:string ;
            owl:onProperty biolink:predicate ],
        [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:predicate ],
        biolink:GeneToGeneAssociation ;
    skos:definition "An interaction between two genes or two gene products. May be physical (e.g. protein binding) or genetic (between genes). May be symmetric (e.g. protein interaction) or directed (e.g. phosphorylation)" ;
    skos:inScheme biolink: ;
    skos:narrowMatch dcid:ProteinProteinInteraction .

biolink:PhenotypicFeatureToEntityAssociationMixin a owl:Class ;
    rdfs:label "phenotypic feature to entity association mixin" ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:onProperty linkml:mixins ;
            owl:someValuesFrom biolink:FrequencyQuantifier ],
        biolink:FeatureOrDiseaseQualifiersToEntityMixin ;
    skos:definition "A mixin applied to any association whose subject (source node) is a phenotypic feature." ;
    skos:inScheme biolink: .

biolink:PosttranslationalModification a owl:Class ;
    rdfs:label "posttranslational modification" ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:onProperty linkml:mixins ;
            owl:someValuesFrom biolink:GeneProductIsoformMixin ],
        biolink:BiologicalEntity ;
    skos:definition "A chemical modification of a polypeptide or protein that occurs after translation, altering its structure, activity, localization, or interactions." ;
    skos:exactMatch <http://purl.obolibrary.org/obo/MOD_00000> ;
    skos:inScheme biolink: .

biolink:ProteinDomain a owl:Class ;
    rdfs:label "protein domain" ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:onProperty linkml:mixins ;
            owl:someValuesFrom biolink:ChemicalEntityOrGeneOrGeneProduct ],
        [ a owl:Restriction ;
            owl:onProperty linkml:mixins ;
            owl:someValuesFrom biolink:GeneGroupingMixin ],
        biolink:BiologicalEntity ;
    skos:definition "A conserved part of protein sequence and (tertiary) structure that can evolve, function, and exist independently of the rest of the protein chain. Protein domains maintain their structure and function independently of the proteins in which they are found." ;
    skos:exactMatch <http://identifiers.org/umls/C1514562>,
        <http://purl.obolibrary.org/obo/NCIT_C13379>,
        SIO:001379 ;
    skos:inScheme biolink: .

biolink:ProteinFamily a owl:Class ;
    rdfs:label "protein family" ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:onProperty linkml:mixins ;
            owl:someValuesFrom biolink:GeneGroupingMixin ],
        [ a owl:Restriction ;
            owl:onProperty linkml:mixins ;
            owl:someValuesFrom biolink:ChemicalEntityOrGeneOrGeneProduct ],
        biolink:BiologicalEntity ;
    skos:definition "A set of proteins coding for diverse functions which, by virtue of their high degree of sequence similarity, are believed to have evolved from a single ancestral gene." ;
    skos:exactMatch <http://purl.obolibrary.org/obo/NCIT_C26004>,
        WIKIDATA:Q2278983 ;
    skos:inScheme biolink: ;
    skos:narrowMatch <http://purl.obolibrary.org/obo/NCIT_C20130>,
        SIO:001380,
        WIKIDATA:Q417841 .

biolink:ProteinLigandAssayResult a owl:Class ;
    rdfs:label "protein ligand assay result" ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:pKon ],
        [ a owl:Restriction ;
            owl:minCardinality 0 ;
            owl:onProperty biolink:pXC50 ],
        [ a owl:Restriction ;
            owl:minCardinality 0 ;
            owl:onProperty biolink:pEC50 ],
        [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:pKi ],
        [ a owl:Restriction ;
            owl:minCardinality 0 ;
            owl:onProperty biolink:pIC50 ],
        [ a owl:Restriction ;
            owl:allValuesFrom biolink:QuantityValue ;
            owl:onProperty biolink:pKoff ],
        [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:pAC50 ],
        [ a owl:Restriction ;
            owl:allValuesFrom biolink:QuantityValue ;
            owl:onProperty biolink:pKi ],
        [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:pIC50 ],
        [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:pKoff ],
        [ a owl:Restriction ;
            owl:minCardinality 0 ;
            owl:onProperty biolink:pKi ],
        [ a owl:Restriction ;
            owl:allValuesFrom biolink:QuantityValue ;
            owl:onProperty biolink:pKon ],
        [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:pEC50 ],
        [ a owl:Restriction ;
            owl:minCardinality 0 ;
            owl:onProperty biolink:pKoff ],
        [ a owl:Restriction ;
            owl:minCardinality 0 ;
            owl:onProperty biolink:pKd ],
        [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:pKd ],
        [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:pXC50 ],
        [ a owl:Restriction ;
            owl:minCardinality 0 ;
            owl:onProperty biolink:pAC50 ],
        [ a owl:Restriction ;
            owl:allValuesFrom biolink:QuantityValue ;
            owl:onProperty biolink:pAC50 ],
        [ a owl:Restriction ;
            owl:allValuesFrom biolink:QuantityValue ;
            owl:onProperty biolink:pEC50 ],
        [ a owl:Restriction ;
            owl:minCardinality 0 ;
            owl:onProperty biolink:pKon ],
        [ a owl:Restriction ;
            owl:allValuesFrom biolink:QuantityValue ;
            owl:onProperty biolink:pIC50 ],
        [ a owl:Restriction ;
            owl:allValuesFrom biolink:QuantityValue ;
            owl:onProperty biolink:pXC50 ],
        [ a owl:Restriction ;
            owl:allValuesFrom biolink:QuantityValue ;
            owl:onProperty biolink:pKd ],
        biolink:StudyResult ;
    skos:definition "The type of study result describing the strength of interaction affinity - or enzymatic interaction - between a ligand and a target protein. Measured binding or enzymatic assay values are generally stated as the negative base 10 logarithm of the raw measurements. For instance (i.e., in a molecular interaction database like BindingDb) if a ligand inhibits a target protein with a pIC50 of 8.6, then the affinity parameter is pIC50 and the affinity value is 8.6." ;
    skos:inScheme biolink: .

biolink:ReactionToParticipantAssociation a owl:Class ;
    rdfs:label "reaction to participant association" ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:allValuesFrom xsd:integer ;
            owl:onProperty biolink:stoichiometry ],
        [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:reaction_side ],
        [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:stoichiometry ],
        [ a owl:Restriction ;
            owl:allValuesFrom biolink:MolecularEntity ;
            owl:onProperty biolink:subject ],
        [ a owl:Restriction ;
            owl:minCardinality 1 ;
            owl:onProperty biolink:subject ],
        [ a owl:Restriction ;
            owl:minCardinality 0 ;
            owl:onProperty biolink:reaction_direction ],
        [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:reaction_direction ],
        [ a owl:Restriction ;
            owl:allValuesFrom biolink:ReactionSideEnum ;
            owl:onProperty biolink:reaction_side ],
        [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:subject ],
        [ a owl:Restriction ;
            owl:minCardinality 0 ;
            owl:onProperty biolink:stoichiometry ],
        [ a owl:Restriction ;
            owl:minCardinality 0 ;
            owl:onProperty biolink:reaction_side ],
        [ a owl:Restriction ;
            owl:allValuesFrom biolink:ReactionDirectionEnum ;
            owl:onProperty biolink:reaction_direction ],
        biolink:ChemicalEntityToChemicalEntityAssociation ;
    skos:definition "An association between a biochemical reaction and a participating molecular entity, qualified by the stoichiometry, the side (reactant vs. product) on which the participant appears, and the direction of the reaction." ;
    skos:inScheme biolink: .

biolink:ReagentTargetedGene a owl:Class ;
    rdfs:label "reagent targeted gene" ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:onProperty linkml:mixins ;
            owl:someValuesFrom biolink:OntologyClass ],
        [ a owl:Restriction ;
            owl:onProperty linkml:mixins ;
            owl:someValuesFrom biolink:PhysicalEssence ],
        [ a owl:Restriction ;
            owl:onProperty linkml:mixins ;
            owl:someValuesFrom biolink:GenomicEntity ],
        biolink:BiologicalEntity ;
    skos:altLabel "sequence targeting reagent" ;
    skos:definition "A gene altered in its expression level in the context of some experiment as a result of being targeted by gene-knockdown reagent(s) such as a morpholino or RNAi." ;
    skos:exactMatch <http://purl.obolibrary.org/obo/GENO_0000504> ;
    skos:inScheme biolink: .

biolink:RelativeFrequencyAnalysisResult a owl:Class ;
    rdfs:label "relative frequency analysis result" ;
    rdfs:subClassOf biolink:StudyResult ;
    skos:definition "A result of a relative frequency analysis." ;
    skos:inScheme biolink: .

biolink:SequenceAssociation a owl:Class ;
    rdfs:label "sequence association" ;
    rdfs:subClassOf biolink:Association ;
    skos:definition "An association between a sequence feature and a nucleic acid entity it is localized to." ;
    skos:inScheme biolink: .

biolink:SeverityValue a owl:Class ;
    rdfs:label "severity value" ;
    rdfs:subClassOf biolink:Attribute ;
    skos:definition "describes the severity of a phenotypic feature or disease" ;
    skos:inScheme biolink: .

biolink:SocioeconomicAttribute a owl:Class ;
    rdfs:label "socioeconomic attribute" ;
    rdfs:subClassOf biolink:Attribute ;
    skos:definition "Attributes relating to a socioeconomic manifestation" ;
    skos:inScheme biolink: .

biolink:StudyPopulation a owl:Class ;
    rdfs:label "study population" ;
    rdfs:subClassOf biolink:PopulationOfIndividualOrganisms ;
    skos:closeMatch WIKIDATA:Q7229825 ;
    skos:definition "A group of people banded together or treated as a group as participants in a research study." ;
    skos:inScheme biolink: .

biolink:StudyVariable a owl:Class ;
    rdfs:label "study variable" ;
    rdfs:subClassOf biolink:InformationContentEntity ;
    skos:closeMatch <http://purl.obolibrary.org/obo/STATO_0000258>,
        SIO:000367 ;
    skos:definition "a variable that is used as a measure in the investigation of a study" ;
    skos:inScheme biolink: ;
    skos:narrowMatch <http://purl.obolibrary.org/obo/NCIT_C142192> .

biolink:TextMiningStudyResult a owl:Class ;
    rdfs:label "text mining study result" ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:minCardinality 0 ;
            owl:onProperty biolink:supporting_document_year ],
        [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:supporting_document_type ],
        [ a owl:Restriction ;
            owl:allValuesFrom xsd:integer ;
            owl:onProperty biolink:object_location_in_text ],
        [ a owl:Restriction ;
            owl:allValuesFrom xsd:float ;
            owl:onProperty biolink:extraction_confidence_score ],
        [ a owl:Restriction ;
            owl:allValuesFrom xsd:integer ;
            owl:onProperty biolink:supporting_document_year ],
        [ a owl:Restriction ;
            owl:minCardinality 0 ;
            owl:onProperty biolink:supporting_text ],
        [ a owl:Restriction ;
            owl:minCardinality 0 ;
            owl:onProperty biolink:supporting_document_type ],
        [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:supporting_text_section_type ],
        [ a owl:Restriction ;
            owl:minCardinality 0 ;
            owl:onProperty biolink:subject_location_in_text ],
        [ a owl:Restriction ;
            owl:allValuesFrom xsd:string ;
            owl:onProperty biolink:supporting_document_type ],
        [ a owl:Restriction ;
            owl:minCardinality 0 ;
            owl:onProperty biolink:supporting_text_section_type ],
        [ a owl:Restriction ;
            owl:allValuesFrom xsd:integer ;
            owl:onProperty biolink:subject_location_in_text ],
        [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:extraction_confidence_score ],
        [ a owl:Restriction ;
            owl:allValuesFrom xsd:string ;
            owl:onProperty biolink:supporting_text ],
        [ a owl:Restriction ;
            owl:allValuesFrom xsd:string ;
            owl:onProperty biolink:supporting_text_section_type ],
        [ a owl:Restriction ;
            owl:minCardinality 0 ;
            owl:onProperty biolink:extraction_confidence_score ],
        [ a owl:Restriction ;
            owl:minCardinality 0 ;
            owl:onProperty biolink:object_location_in_text ],
        [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:supporting_document_year ],
        biolink:StudyResult ;
    skos:definition "A study result that represents information extracted from text using natural language processing techniques. This includes the extracted text, location offsets within the source document, confidence scores, and other metadata related to the text mining process." ;
    skos:inScheme biolink: .

biolink:Treatment a owl:Class ;
    rdfs:label "treatment" ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:allValuesFrom biolink:Procedure ;
            owl:onProperty biolink:has_procedure ],
        [ a owl:Restriction ;
            owl:onProperty linkml:mixins ;
            owl:someValuesFrom biolink:ChemicalOrDrugOrTreatment ],
        [ a owl:Restriction ;
            owl:allValuesFrom biolink:Device ;
            owl:onProperty biolink:has_device ],
        [ a owl:Restriction ;
            owl:minCardinality 0 ;
            owl:onProperty biolink:has_drug ],
        [ a owl:Restriction ;
            owl:allValuesFrom biolink:Drug ;
            owl:onProperty biolink:has_drug ],
        [ a owl:Restriction ;
            owl:minCardinality 0 ;
            owl:onProperty biolink:has_device ],
        [ a owl:Restriction ;
            owl:minCardinality 0 ;
            owl:onProperty biolink:has_procedure ],
        biolink:ExposureEvent ;
    skos:altLabel "medical action",
        "medical intervention" ;
    skos:broadMatch MAXO:0000058 ;
    skos:definition "A treatment is targeted at a disease or phenotype and may involve multiple drug 'exposures', medical devices and/or procedures" ;
    skos:exactMatch <http://purl.obolibrary.org/obo/OGMS_0000090>,
        SIO:001398 ;
    skos:inScheme biolink: .

biolink:VariantToDiseaseAssociation a owl:Class ;
    rdfs:label "variant to disease association" ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:allValuesFrom xsd:string ;
            owl:onProperty biolink:predicate ],
        [ a owl:Restriction ;
            owl:onProperty linkml:mixins ;
            owl:someValuesFrom biolink:VariantToEntityAssociationMixin ],
        [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:object ],
        [ a owl:Restriction ;
            owl:minCardinality 1 ;
            owl:onProperty biolink:object ],
        [ a owl:Restriction ;
            owl:onProperty linkml:mixins ;
            owl:someValuesFrom biolink:EntityToDiseaseAssociationMixin ],
        [ a owl:Restriction ;
            owl:allValuesFrom owl:Thing ;
            owl:onProperty biolink:subject ],
        [ a owl:Restriction ;
            owl:minCardinality 1 ;
            owl:onProperty biolink:predicate ],
        [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:predicate ],
        [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:subject ],
        [ a owl:Restriction ;
            owl:minCardinality 1 ;
            owl:onProperty biolink:subject ],
        [ a owl:Restriction ;
            owl:allValuesFrom owl:Thing ;
            owl:onProperty biolink:object ],
        biolink:Association ;
    skos:definition "An association between a sequence variant and a disease, in which the allele state of the variant is linked to the disease state." ;
    skos:inScheme biolink: ;
    skos:note "TODO decide no how to model pathogenicity" .

biolink:VariantToGeneAssociation a owl:Class ;
    rdfs:label "variant to gene association" ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:predicate ],
        [ a owl:Restriction ;
            owl:onProperty linkml:mixins ;
            owl:someValuesFrom biolink:VariantToEntityAssociationMixin ],
        [ a owl:Restriction ;
            owl:minCardinality 1 ;
            owl:onProperty biolink:predicate ],
        [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:object ],
        [ a owl:Restriction ;
            owl:allValuesFrom biolink:Gene ;
            owl:onProperty biolink:object ],
        [ a owl:Restriction ;
            owl:minCardinality 1 ;
            owl:onProperty biolink:object ],
        [ a owl:Restriction ;
            owl:allValuesFrom xsd:string ;
            owl:onProperty biolink:predicate ],
        biolink:Association ;
    skos:definition "An association between a variant and a gene, where the variant has a genetic association with the gene (i.e. is in linkage disequilibrium)" ;
    skos:inScheme biolink: .

biolink:Virus a owl:Class ;
    rdfs:label "virus" ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:onProperty linkml:mixins ;
            owl:someValuesFrom biolink:SubjectOfInvestigation ],
        biolink:OrganismalEntity ;
    skos:definition "A virus is a microorganism that replicates itself as a microRNA and infects the host cell." ;
    skos:exactMatch STY:T005,
        <http://purl.obolibrary.org/obo/NCBITaxon_10239> ;
    skos:inScheme biolink: ;
    skos:note "see: https://github.com/OBOFoundry/COB/pull/211" .

biolink:acts_upstream_of a owl:ObjectProperty ;
    rdfs:label "acts upstream of" ;
    rdfs:domain biolink:GeneOrGeneProduct ;
    rdfs:range biolink:BiologicalProcess ;
    rdfs:subPropertyOf biolink:acts_upstream_of_or_within ;
    skos:definition "Holds between a gene or gene product and a biological process such that the molecular function of the gene product, by way of a chain of causally linked events, is upstream of and contributes to the execution of the process." ;
    skos:exactMatch RO:0002263 ;
    skos:inScheme biolink: ;
    biolink:canonical_predicate true .

biolink:address a owl:DatatypeProperty ;
    rdfs:label "address" ;
    rdfs:subPropertyOf biolink:node_property ;
    skos:definition "the particulars of the place where someone or an organization is situated.  For now, this slot is a simple text \"blob\" containing all relevant details of the given location for fitness of purpose. For the moment, this \"address\" can include other contact details such as email and phone number(?)." ;
    skos:inScheme biolink: .

biolink:affects_sensitivity_to a owl:ObjectProperty ;
    rdfs:label "affects sensitivity to" ;
    rdfs:domain biolink:ChemicalEntityOrGeneOrGeneProduct ;
    rdfs:range biolink:ChemicalEntityOrGeneOrGeneProduct ;
    rdfs:subPropertyOf biolink:related_to_at_instance_level ;
    skos:definition "holds between two chemical entities or genes or gene products where the action of one affects the susceptibility/sensitivity of a biological entity or system to the other." ;
    skos:exactMatch CTD:affects_response_to ;
    skos:inScheme biolink: ;
    biolink:canonical_predicate true .

biolink:agent_type a owl:ObjectProperty ;
    rdfs:label "agent type" ;
    rdfs:domain biolink:Association ;
    rdfs:range biolink:AgentTypeEnum ;
    rdfs:subPropertyOf biolink:association_slot ;
    skos:definition "Describes the high-level category of agent who originally generated a statement of knowledge or other type of information." ;
    skos:editorialNote "Note that this property indicates the type of agent who produced a final statement of knowledge, which is often different from the agent oragents who produced information used as evidence to support generation of this knowledge. For example, if a human curator concludes that a particular gene variant causes a medical condition - based on their interpretation of information produced by computational modeling tools, automated data analysis pipelines, and robotic laboratory assay systems - the agent_type for this statement is 'manual agent' - despite all of the evidence being created by automated agents. But if any of these systems is programmed to generate knowledge statements directly and without human assistance, the statement would be attributed to an 'automated_agent'." ;
    skos:inScheme biolink: .

biolink:associated_environmental_context a owl:DatatypeProperty ;
    rdfs:label "associated environmental context" ;
    rdfs:subPropertyOf biolink:association_slot ;
    skos:definition """An attribute that can be applied to an association where the association holds between two entities located or occurring in a particular environment. For example, two microbial taxa may interact in the context of a human gut; a disease may give rise to a particular phenotype in a particular environmental exposure.
 # TODO: add examples of values for this property.""" ;
    skos:inScheme biolink: .

biolink:associated_with_likelihood_of a owl:DatatypeProperty ;
    rdfs:label "associated with likelihood of" ;
    rdfs:subPropertyOf biolink:associated_with ;
    skos:definition "A a relationship that holds between two concepts represented by variables for which a statistical dependence is demonstrated, wherein the state or value of one variable predicts the future state or value of the other.  E.g. the statement “An Atrial Fibrillation (Afib) diagnosis is associated with likelihood of a Myocardial Infraction (MI) diagnosis” asserts that the state of having Afib is associated with an increased or decreased likelihood that a patient will later exhibit MI." ;
    skos:inScheme biolink: ;
    biolink:canonical_predicate true .

biolink:associated_with_response_to a owl:DatatypeProperty ;
    rdfs:label "associated with response to" ;
    rdfs:subPropertyOf biolink:associated_with ;
    skos:definition "A statistical association used to indicate that the object of a statement using this predicate induces a response of some kind in the subject entity.  Intentionally broad in definition, this predicate should be used with qualifiers to narrow the type of response (E.g. whether the response is therapeutic, phenotypic, detrimental, resistant, etc. is captured in context, direction, and aspect qualifiers)." ;
    skos:inScheme biolink: ;
    biolink:canonical_predicate true .

biolink:association_basis_qualifier a owl:ObjectProperty ;
    rdfs:label "association basis qualifier" ;
    rdfs:range biolink:AssociationBasisEnum ;
    rdfs:subPropertyOf biolink:statement_qualifier ;
    skos:definition "A statement-level qualifier used with the 'associated with' predicate (or one of its subpredicates) to indicate the biological, clinical, or statistical basis of the asserted association. Use this qualifier when no more specific predicate exists to capture the intended meaning of the association." ;
    skos:inScheme biolink: .

biolink:broad_synonym a owl:DatatypeProperty ;
    rdfs:label "broad synonym" ;
    rdfs:subPropertyOf biolink:synonym ;
    skos:definition "An alternate label for an entity whose meaning is broader (more general) than the primary label but is still useful as a lexical alternative." ;
    skos:exactMatch OIO:hasBroadSynonym ;
    skos:inScheme biolink: .

biolink:chapter a owl:DatatypeProperty ;
    rdfs:label "chapter" ;
    rdfs:domain biolink:BookChapter ;
    rdfs:subPropertyOf biolink:node_property ;
    skos:definition "chapter of a book" ;
    skos:exactMatch WIKIDATA:Q1980247 ;
    skos:inScheme biolink: .

biolink:chembl_availability_type a owl:DatatypeProperty ;
    rdfs:label "chembl availability type" ;
    rdfs:range xsd:string ;
    skos:definition "Text indicating the availability type of the chemical entity." ;
    skos:inScheme <https://w3id.org/biolink/biolink-model/attributes> .

biolink:chembl_black_box_warning a owl:DatatypeProperty ;
    rdfs:label "chembl black box warning" ;
    rdfs:range xsd:string ;
    skos:definition "Text describing black box warnings for use of chemicals as therapeutics." ;
    skos:inScheme <https://w3id.org/biolink/biolink-model/attributes> .

biolink:chembl_chirality a owl:DatatypeProperty ;
    rdfs:label "chembl chirality" ;
    rdfs:range xsd:string ;
    skos:definition "Tern indicating the chirality of the chemical entity." ;
    skos:inScheme <https://w3id.org/biolink/biolink-model/attributes> .

biolink:chembl_drug_warning a owl:DatatypeProperty ;
    rdfs:label "chembl drug warning" ;
    rdfs:range xsd:string ;
    skos:definition "Text describing warnings for use of chemicals as therapeutics." ;
    skos:inScheme <https://w3id.org/biolink/biolink-model/attributes> .

biolink:chembl_natural_product a owl:DatatypeProperty ;
    rdfs:label "chembl natural product" ;
    rdfs:range xsd:boolean ;
    skos:definition "Flag indicating if a chemical entity is a natural product." ;
    skos:inScheme <https://w3id.org/biolink/biolink-model/attributes> .

biolink:chembl_prodrug a owl:DatatypeProperty ;
    rdfs:label "chembl prodrug" ;
    rdfs:range xsd:boolean ;
    skos:definition "Flag indicating if a drug is a prodrug that is active only after being metabolized by the body." ;
    skos:inScheme <https://w3id.org/biolink/biolink-model/attributes> .

biolink:chi_squared_dof a owl:DatatypeProperty ;
    rdfs:label "chi squared dof" ;
    rdfs:range xsd:integer ;
    rdfs:subPropertyOf biolink:node_property ;
    skos:definition "Degrees of freedom (dof) in a chi-squared test referring to the number of values in the final calculation of a statistic that are free to vary" ;
    skos:inScheme biolink: .

biolink:chi_squared_p a owl:DatatypeProperty ;
    rdfs:label "chi squared p" ;
    rdfs:range xsd:float ;
    rdfs:subPropertyOf biolink:node_property ;
    skos:definition "The chi-square p-value tells you the probability that the observed differences (or associations) in your data occurred by random chance, assuming the null hypothesis is true." ;
    skos:inScheme biolink: .

biolink:chi_squared_statistic a owl:DatatypeProperty ;
    rdfs:label "chi squared statistic" ;
    rdfs:range xsd:float ;
    rdfs:subPropertyOf biolink:node_property ;
    skos:definition "The chi-squared statistic measures how much observed data deviate from expected values under the null hypothesis." ;
    skos:exactMatch <http://purl.obolibrary.org/obo/STATO_0000030> ;
    skos:inScheme biolink: .

biolink:clinical_approval_status a owl:ObjectProperty ;
    rdfs:label "clinical approval status" ;
    rdfs:range biolink:ClinicalApprovalStatusEnum ;
    rdfs:subPropertyOf biolink:association_slot ;
    skos:definition "The clinical approval status of a chemical entity for treating a specific disease or condition, as captured in the context of the association between the chemical and the disease." ;
    skos:inScheme biolink: .

biolink:clinical_trial_age_range a owl:DatatypeProperty ;
    rdfs:label "clinical trial age range" ;
    rdfs:domain biolink:ClinicalTrial ;
    rdfs:range xsd:string ;
    rdfs:subPropertyOf biolink:node_property ;
    skos:definition "The age range of a clinical trial as determined by clinicaltrials.gov" ;
    skos:inScheme biolink: .

biolink:clinical_trial_brief_title a owl:DatatypeProperty ;
    rdfs:label "clinical trial brief title" ;
    rdfs:domain biolink:ClinicalTrial ;
    rdfs:range xsd:string ;
    rdfs:subPropertyOf biolink:node_property ;
    skos:definition "The brief title of a clinical trial as determined by clinicaltrials.gov" ;
    skos:inScheme biolink: .

biolink:clinical_trial_enrollment a owl:DatatypeProperty ;
    rdfs:label "clinical trial enrollment" ;
    rdfs:domain biolink:ClinicalTrial ;
    rdfs:range xsd:integer ;
    rdfs:subPropertyOf biolink:node_property ;
    skos:definition "The enrollment number of a clinical trial as determined by clinicaltrials.gov" ;
    skos:inScheme biolink: .

biolink:clinical_trial_enrollment_type a owl:DatatypeProperty ;
    rdfs:label "clinical trial enrollment type" ;
    rdfs:domain biolink:ClinicalTrial ;
    rdfs:range xsd:string ;
    rdfs:subPropertyOf biolink:node_property ;
    skos:definition "The enrollment type of a clinical trial as determined by clinicaltrials.gov (actual, anticipated, or estimated)" ;
    skos:inScheme biolink: .

biolink:clinical_trial_intervention_model a owl:DatatypeProperty ;
    rdfs:label "clinical trial intervention model" ;
    rdfs:domain biolink:ClinicalTrial ;
    rdfs:range xsd:string ;
    rdfs:subPropertyOf biolink:node_property ;
    skos:definition "The intervention model of a clinical trial as determined by clinicaltrials.gov.  The most common values are SINGLE_GROUP, PARALLEL, CROSSOVER, FACTORIAL, and (null)." ;
    skos:inScheme biolink: .

biolink:clinical_trial_overall_status a owl:ObjectProperty ;
    rdfs:label "clinical trial overall status" ;
    rdfs:domain biolink:ClinicalTrial ;
    rdfs:range biolink:ClinicalTrialStatusEnum ;
    rdfs:subPropertyOf biolink:node_property ;
    skos:definition "The overall status of a clinical trial as determined by clinicaltrials.gov" ;
    skos:inScheme biolink: .

biolink:clinical_trial_phase a owl:ObjectProperty ;
    rdfs:label "clinical trial phase" ;
    rdfs:range biolink:ResearchPhaseEnum ;
    rdfs:subPropertyOf biolink:node_property ;
    skos:definition "The phase that a clinical trials study represents" ;
    skos:inScheme biolink: .

biolink:clinical_trial_primary_purpose a owl:DatatypeProperty ;
    rdfs:label "clinical trial primary purpose" ;
    rdfs:domain biolink:ClinicalTrial ;
    rdfs:range xsd:string ;
    rdfs:subPropertyOf biolink:node_property ;
    skos:altLabel "primary purpose" ;
    skos:definition "The primary purpose of a clinical trial as determined by clinicaltrials.gov.  The most common values are TREATMENT and PREVENTION. Other possible values include BASIC_SCIENCE, SUPPORTIVE_CARE, DIAGNOSTIC, HEALTH_SERVICES_RESEARCH, SCREENING, DEVICE_FEASIBILITY, OTHER, and (null)." ;
    skos:inScheme biolink: .

biolink:clinical_trial_start_date a owl:DatatypeProperty ;
    rdfs:label "clinical trial start date" ;
    rdfs:domain biolink:ClinicalTrial ;
    rdfs:range xsd:string ;
    rdfs:subPropertyOf biolink:node_property ;
    skos:definition "The start date of a clinical trial as determined by clinicaltrials.gov" ;
    skos:inScheme biolink: .

biolink:clinical_trial_tested_intervention a owl:DatatypeProperty ;
    rdfs:label "clinical trial tested intervention" ;
    rdfs:domain biolink:ClinicalTrial ;
    rdfs:range xsd:string ;
    rdfs:subPropertyOf biolink:node_property ;
    skos:definition "Records whether the clinical trials are testing the intervention." ;
    skos:inScheme biolink: .

biolink:deprecated a owl:DatatypeProperty ;
    rdfs:label "deprecated" ;
    rdfs:range xsd:boolean ;
    skos:definition "A boolean flag indicating that an entity is no longer considered current or valid." ;
    skos:exactMatch OIO:ObsoleteClass ;
    skos:inScheme biolink: .

biolink:description a owl:DatatypeProperty ;
    rdfs:label "description" ;
    rdfs:range xsd:string ;
    skos:altLabel "definition" ;
    skos:definition "a human-readable description of an entity" ;
    skos:exactMatch IAO:0000115,
        skos:definitions ;
    skos:inScheme biolink: ;
    skos:narrowMatch gff3:Description .

biolink:disease_context_qualifier a owl:ObjectProperty ;
    rdfs:label "disease context qualifier" ;
    rdfs:range biolink:Disease ;
    rdfs:subPropertyOf biolink:context_qualifier ;
    skos:definition "A context qualifier representing a disease or condition in which a relationship expressed in an association took place." ;
    skos:inScheme biolink: .

biolink:distribution_download_url a owl:DatatypeProperty ;
    rdfs:label "distribution download url" ;
    rdfs:domain biolink:DatasetDistribution ;
    rdfs:subPropertyOf biolink:node_property ;
    skos:definition "A URL from which a specific distribution (serialization or format) of a dataset may be directly downloaded; corresponds to dcat:downloadURL specialised for the dataset distribution domain." ;
    skos:exactMatch dcat:downloadURL ;
    skos:inScheme biolink: .

biolink:drug_regulatory_status_world_wide a owl:ObjectProperty ;
    rdfs:label "drug regulatory status world wide" ;
    rdfs:range biolink:ApprovalStatusEnum ;
    skos:altLabel "max phase" ;
    skos:definition "An agglomeration of drug regulatory status worldwide. Not specific to FDA." ;
    skos:exactMatch <http://purl.obolibrary.org/obo/NCIT_C172573> ;
    skos:inScheme biolink: ;
    skos:narrowMatch REPODB:clinically_tested_approved_unknown_phase,
        REPODB:clinically_tested_suspended_phase_0,
        REPODB:clinically_tested_suspended_phase_1,
        REPODB:clinically_tested_suspended_phase_1_or_phase_2,
        REPODB:clinically_tested_suspended_phase_2,
        REPODB:clinically_tested_suspended_phase_2_or_phase_3,
        REPODB:clinically_tested_suspended_phase_3,
        REPODB:clinically_tested_terminated_phase_0,
        REPODB:clinically_tested_terminated_phase_1,
        REPODB:clinically_tested_terminated_phase_1_or_phase_2,
        REPODB:clinically_tested_terminated_phase_2,
        REPODB:clinically_tested_terminated_phase_2_or_phase_3,
        REPODB:clinically_tested_terminated_phase_3,
        REPODB:clinically_tested_withdrawn_phase_0,
        REPODB:clinically_tested_withdrawn_phase_1,
        REPODB:clinically_tested_withdrawn_phase_1_or_phase_2,
        REPODB:clinically_tested_withdrawn_phase_2,
        REPODB:clinically_tested_withdrawn_phase_2_or_phase_3,
        REPODB:clinically_tested_withdrawn_phase_3,
        <http://purl.obolibrary.org/obo/NCIT_R172>,
        <http://purl.obolibrary.org/obo/NCIT_regimen_has_accepted_use_for_disease> .

biolink:druggable_gene_category a owl:ObjectProperty ;
    rdfs:label "druggable gene category" ;
    rdfs:range biolink:DruggableGeneCategoryEnum ;
    skos:definition "Classification of druggable genes based on knowledge about drug or small molecule activities." ;
    skos:inScheme biolink: .

biolink:elevate_to_prediction a owl:DatatypeProperty ;
    rdfs:label "elevate to prediction" ;
    rdfs:range xsd:boolean ;
    rdfs:subPropertyOf biolink:node_property ;
    skos:definition "A boolean flag indicating whether a clinical trial finding should be elevated to a prediction." ;
    skos:inScheme biolink: .

biolink:end_interbase_coordinate a owl:DatatypeProperty ;
    rdfs:label "end interbase coordinate" ;
    rdfs:subPropertyOf biolink:interbase_coordinate ;
    skos:closeMatch <http://biohackathon.org/resource/faldo#end> ;
    skos:definition "The position at which the subject nucleic acid entity ends on the chromosome or other entity to which it is located on." ;
    skos:inScheme biolink: ;
    biolink:opposite_of "start interbase coordinate" .

biolink:exact_synonym a owl:DatatypeProperty ;
    rdfs:label "exact synonym" ;
    rdfs:subPropertyOf biolink:synonym ;
    skos:definition "An alternate label for an entity that denotes exactly the same meaning as the primary label and is interchangeable with it in all contexts." ;
    skos:exactMatch OIO:hasExactSynonym ;
    skos:inScheme biolink: .

biolink:exposure_additional_condition a owl:DatatypeProperty ;
    rdfs:label "exposure additional condition" ;
    rdfs:domain biolink:ExposureEvent ;
    rdfs:range xsd:string ;
    rdfs:subPropertyOf biolink:node_property ;
    skos:definition "Additional conditions impacting an exposure event." ;
    skos:inScheme biolink: .

biolink:exposure_duration a owl:DatatypeProperty ;
    rdfs:label "exposure duration" ;
    rdfs:domain biolink:ExposureEvent ;
    rdfs:range xsd:time ;
    rdfs:subPropertyOf biolink:node_property ;
    skos:definition "Duration of an exposure event." ;
    skos:inScheme biolink: .

biolink:exposure_end_age a owl:DatatypeProperty ;
    rdfs:label "exposure end age" ;
    rdfs:domain biolink:ExposureEvent ;
    rdfs:range xsd:integer ;
    rdfs:subPropertyOf biolink:node_property ;
    skos:definition "Ending stage of an exposure event." ;
    skos:inScheme biolink: .

biolink:exposure_magnitude a owl:DatatypeProperty ;
    rdfs:label "exposure magnitude" ;
    rdfs:domain biolink:ExposureEvent ;
    rdfs:range xsd:string ;
    rdfs:subPropertyOf biolink:node_property ;
    skos:definition "Magnitude of an exposure event, e.g, parts per million of a toxic chemical." ;
    skos:inScheme biolink: .

biolink:exposure_route a owl:DatatypeProperty ;
    rdfs:label "exposure route" ;
    rdfs:domain biolink:ExposureEvent ;
    rdfs:range xsd:string ;
    rdfs:subPropertyOf biolink:node_property ;
    skos:definition "Route of exposure." ;
    skos:inScheme biolink: .

biolink:exposure_start_age a owl:DatatypeProperty ;
    rdfs:label "exposure start age" ;
    rdfs:domain biolink:ExposureEvent ;
    rdfs:range xsd:integer ;
    rdfs:subPropertyOf biolink:node_property ;
    skos:definition "Starting age of an exposure event." ;
    skos:inScheme biolink: .

biolink:exposure_type a owl:DatatypeProperty ;
    rdfs:label "exposure type" ;
    rdfs:domain biolink:ExposureEvent ;
    rdfs:range xsd:string ;
    rdfs:subPropertyOf biolink:node_property ;
    skos:definition "Type of exposure" ;
    skos:inScheme biolink: .

biolink:exposure_vehicle a owl:DatatypeProperty ;
    rdfs:label "exposure vehicle" ;
    rdfs:domain biolink:ExposureEvent ;
    rdfs:range xsd:string ;
    rdfs:subPropertyOf biolink:node_property ;
    skos:definition "Type of an exposure event." ;
    skos:inScheme biolink: .

biolink:expression_site a owl:ObjectProperty ;
    rdfs:label "expression site" ;
    rdfs:range biolink:AnatomicalEntity ;
    rdfs:subPropertyOf biolink:association_slot ;
    skos:definition "location in which gene or protein expression takes place. May be cell, tissue, or organ." ;
    skos:inScheme biolink: .

biolink:extraction_confidence_score a owl:DatatypeProperty ;
    rdfs:label "extraction confidence score" ;
    rdfs:range xsd:float ;
    rdfs:subPropertyOf biolink:node_property ;
    skos:definition "A quantitative confidence value that represents the probability of obtaining a result at least as extreme as that actually obtained, assuming that the actual value was the result of chance alone." ;
    skos:inScheme biolink: .

biolink:fisher_exact_odds_ratio a owl:DatatypeProperty ;
    rdfs:label "fisher exact odds ratio" ;
    rdfs:range xsd:float ;
    rdfs:subPropertyOf biolink:node_property ;
    skos:definition """The Fisher Exact Test is used to determine whether there is a non-random association between two categorical variables in a 2×2 contingency table, especially when sample sizes are small. The odds ratio (OR) quantifies the strength of that association.
   OR = 1 implies No association
   OR > 1 implies Positive association (Group A more likely to have Outcome 1)
   OR < 1 implies Negative association (Group A less likely to have Outcome 1)""" ;
    skos:inScheme biolink: .

biolink:fisher_exact_p a owl:DatatypeProperty ;
    rdfs:label "fisher exact p" ;
    rdfs:range xsd:float ;
    rdfs:subPropertyOf biolink:node_property ;
    skos:definition "The Fisher exact p-value tells you the probability of observing a table as extreme as (or more extreme than) your actual data, assuming that the null hypothesis of independence is true. It's most commonly used for 2×2 contingency tables, especially when sample sizes are small or expected counts are low." ;
    skos:inScheme biolink: .

biolink:format a owl:DatatypeProperty ;
    rdfs:label "format" ;
    rdfs:domain biolink:InformationContentEntity ;
    rdfs:subPropertyOf biolink:node_property ;
    skos:definition "The file format, physical medium, or representational form of the information content entity; for digital resources typically a MIME type or format identifier. Corresponds to dct:format." ;
    skos:exactMatch dct:format,
        WIKIDATA_PROPERTY:P2701 ;
    skos:inScheme biolink: .

biolink:frequency_qualifier a owl:DatatypeProperty ;
    rdfs:label "frequency qualifier" ;
    rdfs:range <http://purl.obolibrary.org/obo/UO_0000105> ;
    rdfs:subPropertyOf biolink:qualifier ;
    skos:definition "a qualifier used in a phenotypic association to state how frequent the phenotype is observed in the subject" ;
    skos:inScheme biolink: .

biolink:full_name a owl:DatatypeProperty ;
    rdfs:label "full name" ;
    rdfs:domain biolink:NamedThing ;
    rdfs:range xsd:string ;
    rdfs:subPropertyOf biolink:node_property ;
    skos:definition "a long-form human readable name for a thing" ;
    skos:inScheme biolink: .

biolink:gene2phenotype_confidence_category a owl:DatatypeProperty ;
    rdfs:label "gene2phenotype confidence category" ;
    rdfs:range xsd:string ;
    skos:definition "A term used by EBI Gene2Phenotype to describe the confidence that the association is real. GenCC confidence terms are used for different levels of confidence (enum).  See https://www.ebi.ac.uk/gene2phenotype/about/terminology#g2p-confidence-section." ;
    skos:inScheme <https://w3id.org/biolink/biolink-model/attributes> .

biolink:genome_build a owl:ObjectProperty ;
    rdfs:label "genome build" ;
    rdfs:range biolink:StrandEnum ;
    rdfs:subPropertyOf biolink:sequence_localization_attribute ;
    skos:definition "The version of the genome on which a feature is located. For example, GRCh38 for Homo sapiens." ;
    skos:exactMatch gff3:strand ;
    skos:inScheme biolink: .

biolink:has_binary_relation a owl:ObjectProperty ;
    rdfs:label "has binary relation" ;
    rdfs:range biolink:BinaryRelationEnum ;
    skos:definition "Qualifies a value context with a mathematical binary relation." ;
    skos:inScheme biolink: .

biolink:has_biological_sex a owl:ObjectProperty ;
    rdfs:label "has biological sex" ;
    rdfs:range biolink:BiologicalSex ;
    skos:definition "The biological sex of the entity regarding a case description from a phenopacket" ;
    skos:inScheme biolink: .

biolink:has_chemical_role a owl:ObjectProperty ;
    rdfs:label "has chemical role" ;
    rdfs:domain biolink:ChemicalEntity ;
    rdfs:range biolink:ChemicalRole ;
    rdfs:subPropertyOf biolink:related_to_at_concept_level ;
    owl:inverseOf biolink:is_chemical_role_of ;
    skos:definition "A role is particular behaviour which a chemical entity may exhibit." ;
    skos:inScheme biolink: ;
    skos:note "We expect primarily to use CHEBI chemical roles here; however, we are looking for a mapping between CHEBI And ATC codes to support this slot." .

biolink:has_confidence_score a owl:DatatypeProperty ;
    rdfs:label "has confidence score" ;
    rdfs:range xsd:float ;
    rdfs:subPropertyOf biolink:association_slot ;
    skos:closeMatch <http://purl.obolibrary.org/obo/SEPIO_0000167>,
        <http://purl.obolibrary.org/obo/SEPIO_0000187> ;
    skos:definition "connects an association to a quantitative (numeric) value that can be interpreted as an indicator of the degree of confidence that a piece of information is true, and accurately reflects the aspect of reality it is about." ;
    skos:exactMatch <http://purl.obolibrary.org/obo/SEPIO_0000168> ;
    skos:inScheme biolink: .

biolink:has_dataset a owl:ObjectProperty ;
    rdfs:label "has dataset" ;
    rdfs:domain biolink:DatasetVersion ;
    rdfs:range biolink:Dataset ;
    rdfs:subPropertyOf biolink:node_property ;
    skos:broadMatch dct:source ;
    skos:definition "Links a dataset version to the underlying dataset that it is a version of." ;
    skos:inScheme biolink: .

biolink:has_distribution a owl:ObjectProperty ;
    rdfs:label "has distribution" ;
    rdfs:domain biolink:DatasetVersion ;
    rdfs:range biolink:DatasetDistribution ;
    rdfs:subPropertyOf biolink:node_property ;
    skos:definition "Links a dataset version to one of its dataset distributions (a specific representation or serialization of the dataset)." ;
    skos:inScheme biolink: .

biolink:has_gene_or_gene_product a owl:ObjectProperty ;
    rdfs:label "has gene or gene product" ;
    rdfs:range biolink:Gene ;
    rdfs:subPropertyOf biolink:node_property ;
    skos:definition "connects an entity with one or more gene or gene products" ;
    skos:inScheme biolink: .

biolink:has_numeric_value a owl:DatatypeProperty ;
    rdfs:label "has numeric value" ;
    rdfs:domain biolink:QuantityValue ;
    rdfs:range xsd:double ;
    skos:definition "connects a quantity value to a number" ;
    skos:exactMatch qud:quantityValue ;
    skos:inScheme biolink: .

biolink:has_percentage a owl:DatatypeProperty ;
    rdfs:label "has percentage" ;
    rdfs:range xsd:double ;
    rdfs:subPropertyOf biolink:aggregate_statistic ;
    skos:definition "equivalent to has quotient multiplied by 100" ;
    skos:inScheme biolink: .

biolink:has_qualitative_value a owl:ObjectProperty ;
    rdfs:label "has qualitative value" ;
    rdfs:domain biolink:Attribute ;
    rdfs:range biolink:NamedThing ;
    skos:definition "connects an attribute to a value" ;
    skos:inScheme biolink: .

biolink:has_taxonomic_rank a owl:ObjectProperty ;
    rdfs:label "has taxonomic rank" ;
    rdfs:range biolink:TaxonomicRank ;
    rdfs:subPropertyOf biolink:node_property ;
    skos:definition "The taxonomic rank (e.g. species, genus, family, order, kingdom) assigned to an organism taxon." ;
    skos:inScheme biolink: ;
    skos:mappingRelation WIKIDATA:P105 .

biolink:has_unit a owl:DatatypeProperty ;
    rdfs:label "has unit" ;
    rdfs:domain biolink:QuantityValue ;
    rdfs:range <http://purl.obolibrary.org/obo/UO_0000000> ;
    skos:closeMatch UO-PROPERTY:is_unit_of,
        EFO:0001697 ;
    skos:definition "connects a quantity value to a unit" ;
    skos:exactMatch IAO:0000039,
        qud:unit ;
    skos:inScheme biolink: ;
    skos:narrowMatch <http://purl.obolibrary.org/obo/SNOMED_has_concentration_strength_denominator_unit>,
        <http://purl.obolibrary.org/obo/SNOMED_has_concentration_strength_numerator_unit>,
        <http://purl.obolibrary.org/obo/SNOMED_has_presentation_strength_denominator_unit>,
        <http://purl.obolibrary.org/obo/SNOMED_has_presentation_strength_numerator_unit>,
        <http://purl.obolibrary.org/obo/SNOMED_has_unit_of_presentation> .

biolink:has_unit_prefix a owl:DatatypeProperty ;
    rdfs:label "has unit prefix" ;
    rdfs:domain biolink:QuantityValue ;
    rdfs:range <http://purl.obolibrary.org/obo/UO_0000046> ;
    skos:definition "relates to scaling of the associated quantitative unit" ;
    skos:inScheme biolink: .

biolink:has_upstream_or_within_actor a owl:ObjectProperty ;
    rdfs:label "has upstream or within actor" ;
    rdfs:domain biolink:BiologicalProcess ;
    rdfs:range biolink:GeneOrGeneProduct ;
    rdfs:subPropertyOf biolink:related_to_at_instance_level ;
    owl:inverseOf biolink:acts_upstream_of_or_within ;
    skos:inScheme biolink: .

biolink:highest_FDA_approval_status a owl:ObjectProperty ;
    rdfs:label "highest FDA approval status" ;
    rdfs:range biolink:ApprovalStatusEnum ;
    skos:definition "Should be the highest level of FDA approval this chemical entity or device has, regardless of which disease, condition or phenotype it is currently being reviewed to treat.  For specific levels of FDA approval for a specific condition, disease, phenotype, etc., see the association slot, 'clinical approval status.'" ;
    skos:inScheme biolink: .

biolink:homologous_to a owl:DatatypeProperty,
        owl:SymmetricProperty ;
    rdfs:label "homologous to" ;
    rdfs:subPropertyOf biolink:similar_to ;
    skos:altLabel "in homology relationship with" ;
    skos:definition "holds between two biological entities that have common evolutionary origin" ;
    skos:exactMatch RO:HOM0000001,
        SIO:010302 ;
    skos:inScheme biolink: ;
    skos:narrowMatch UBERON_CORE:sexually_homologous_to ;
    skos:note "typically used to describe homology relationships between genes or gene products" ;
    biolink:canonical_predicate true .

biolink:in_taxon_label a owl:DatatypeProperty ;
    rdfs:label "in taxon label" ;
    rdfs:domain biolink:ThingWithTaxon ;
    rdfs:range xsd:string ;
    rdfs:subPropertyOf biolink:node_property ;
    skos:definition "The human readable scientific name for the taxon of the entity." ;
    skos:exactMatch WIKIDATA_PROPERTY:P225 ;
    skos:inScheme biolink: ;
    biolink:denormalized true .

biolink:information_content a owl:DatatypeProperty ;
    rdfs:label "information content" ;
    rdfs:range xsd:float ;
    skos:definition "Information content (IC) value for a term, primarily from Automats." ;
    skos:inScheme <https://w3id.org/biolink/biolink-model/attributes> .

biolink:ingest_date a owl:DatatypeProperty ;
    rdfs:label "ingest date" ;
    rdfs:domain biolink:DatasetVersion ;
    rdfs:subPropertyOf biolink:node_property ;
    skos:broadMatch dct:issued ;
    skos:definition "The date on which a dataset version was ingested into the local knowledge graph or downstream data system; a specialization of dct:issued for the ingestion context." ;
    skos:inScheme biolink: .

biolink:inheritance a owl:ObjectProperty ;
    rdfs:label "inheritance" ;
    rdfs:domain biolink:DiseaseOrPhenotypicFeature ;
    rdfs:range biolink:GeneticInheritance ;
    rdfs:subPropertyOf biolink:node_property ;
    skos:definition "Connects genetic inheritance to a disease or phenotypic feature, as a node property." ;
    skos:exactMatch <http://purl.obolibrary.org/obo/OMIM_has_inheritance_type> ;
    skos:inScheme biolink: .

biolink:interacting_molecules_category a owl:ObjectProperty ;
    rdfs:label "interacting molecules category" ;
    rdfs:range biolink:OntologyClass ;
    rdfs:subPropertyOf biolink:association_slot ;
    skos:exactMatch MI:1046 ;
    skos:inScheme biolink: .

biolink:is_metabolite a owl:DatatypeProperty ;
    rdfs:label "is metabolite" ;
    rdfs:domain biolink:MolecularEntity ;
    rdfs:range xsd:boolean ;
    rdfs:subPropertyOf biolink:node_property ;
    skos:definition "indicates whether a molecular entity is a metabolite" ;
    skos:exactMatch <http://purl.obolibrary.org/obo/CHEBI_25212> ;
    skos:inScheme biolink: .

biolink:is_supplement a owl:DatatypeProperty ;
    rdfs:label "is supplement" ;
    rdfs:domain biolink:ChemicalMixture ;
    rdfs:subPropertyOf biolink:node_property ;
    skos:definition "A boolean or categorical flag indicating that a chemical mixture is marketed, formulated, or used as a dietary or nutritional supplement rather than as a conventional drug or food." ;
    skos:inScheme biolink: .

biolink:is_toxic a owl:DatatypeProperty ;
    rdfs:label "is toxic" ;
    rdfs:range xsd:boolean ;
    rdfs:subPropertyOf biolink:node_property ;
    skos:definition "A boolean flag indicating whether a chemical entity is toxic under ordinary conditions of exposure." ;
    skos:inScheme biolink: .

biolink:knowledge_level a owl:ObjectProperty ;
    rdfs:label "knowledge level" ;
    rdfs:domain biolink:Association ;
    rdfs:range biolink:KnowledgeLevelEnum ;
    rdfs:subPropertyOf biolink:association_slot ;
    skos:altLabel "knowledge type" ;
    skos:definition "Describes the level of knowledge expressed in a statement, based on the reasoning or analysis methods used to generate the statement, or the scope or specificity of what the statement expresses to be true." ;
    skos:editorialNote "The notion of a 'level' of knowledge can in one sense relate to the strength of a statement - i.e. how confident we are that it says something true about our domain of discourse. Here, we can generally consider Assertions to be stronger than Entailments to be stronger than Predictions. But in another sense, 'level' of knowledge can refer to the scope or specificity of what a statement expresses - on a spectrum from context-specific results of a data analysis, to generalized assertions of knowledge or fact. Here, Statistical Associations and  Observations represent more foundational statements that are only slightly removed from the data on which they are based (the former reporting the direct results of  an analysis in terms of correlations between variables in the data, and the latter describing phenomena that were observed/reported to have occurred)." ;
    skos:inScheme biolink: .

biolink:latitude a owl:DatatypeProperty ;
    rdfs:label "latitude" ;
    rdfs:range xsd:float ;
    rdfs:subPropertyOf biolink:node_property ;
    skos:definition "latitude" ;
    skos:exactMatch wgs1:lat ;
    skos:inScheme biolink: .

biolink:license a owl:DatatypeProperty ;
    rdfs:label "license" ;
    rdfs:domain biolink:InformationContentEntity ;
    rdfs:subPropertyOf biolink:node_property ;
    skos:definition "A legal instrument under which the information content entity is made available, typically identified by a URL or CURIE pointing to a license document." ;
    skos:exactMatch dct:license ;
    skos:inScheme biolink: ;
    skos:narrowMatch WIKIDATA_PROPERTY:P275 .

biolink:likelihood_affected_by a owl:DatatypeProperty ;
    rdfs:label "likelihood affected by" ;
    rdfs:subPropertyOf biolink:related_to_at_instance_level ;
    owl:inverseOf biolink:affects_likelihood_of ;
    skos:inScheme biolink: .

biolink:located_in a owl:ObjectProperty ;
    rdfs:label "located in" ;
    rdfs:domain biolink:NamedThing ;
    rdfs:range biolink:NamedThing ;
    rdfs:subPropertyOf biolink:related_to_at_instance_level ;
    skos:definition "holds between a material entity and a material entity or site within which it is located (but of which it is not considered a part)" ;
    skos:exactMatch FMA:has_location,
        RO:0001025 ;
    skos:inScheme biolink: ;
    skos:narrowMatch <http://identifiers.org/hmdb/at_cellular_location>,
        <http://identifiers.org/hmdb/at_tissue>,
        <http://identifiers.org/hmdb/in_biospecimen>,
        LOINC:has_imaging_focus,
        <http://purl.obolibrary.org/obo/BSPO_0000107>,
        <http://purl.obolibrary.org/obo/BSPO_0000108>,
        <http://purl.obolibrary.org/obo/BSPO_0000120>,
        <http://purl.obolibrary.org/obo/BSPO_0000121>,
        <http://purl.obolibrary.org/obo/BSPO_0000122>,
        <http://purl.obolibrary.org/obo/BSPO_0000123>,
        <http://purl.obolibrary.org/obo/BSPO_0000124>,
        <http://purl.obolibrary.org/obo/BSPO_0000125>,
        <http://purl.obolibrary.org/obo/BSPO_0000126>,
        <http://purl.obolibrary.org/obo/BSPO_0001100>,
        <http://purl.obolibrary.org/obo/BSPO_0001101>,
        <http://purl.obolibrary.org/obo/BSPO_0001107>,
        <http://purl.obolibrary.org/obo/BSPO_0015101>,
        <http://purl.obolibrary.org/obo/BSPO_0015102>,
        <http://purl.obolibrary.org/obo/BSPO_0015202>,
        FMA:has_location,
        GOREL:0001004,
        <http://purl.obolibrary.org/obo/NCIT_R100>,
        <http://purl.obolibrary.org/obo/NCIT_R145>,
        <http://purl.obolibrary.org/obo/NCIT_R155>,
        <http://purl.obolibrary.org/obo/NCIT_R156>,
        <http://purl.obolibrary.org/obo/NCIT_R165>,
        <http://purl.obolibrary.org/obo/NCIT_R166>,
        <http://purl.obolibrary.org/obo/NCIT_R167>,
        <http://purl.obolibrary.org/obo/NCIT_R168>,
        <http://purl.obolibrary.org/obo/NCIT_R169>,
        <http://purl.obolibrary.org/obo/NCIT_R170>,
        <http://purl.obolibrary.org/obo/NCIT_R171>,
        <http://purl.obolibrary.org/obo/NCIT_R40>,
        RO:0002303,
        <http://purl.obolibrary.org/obo/SNOMED_has_finding_site>,
        <http://purl.obolibrary.org/obo/SNOMED_has_indirect_procedure_site>,
        <http://purl.obolibrary.org/obo/SNOMED_has_inherent_location>,
        UBERON_CORE:in_central_side_of,
        UBERON_CORE:in_innermost_side_of,
        UBERON_CORE:in_outermost_side_of,
        EFO:0000784 ;
    biolink:canonical_predicate true .

biolink:log_odds_ratio a owl:DatatypeProperty ;
    rdfs:label "log odds ratio" ;
    rdfs:range xsd:float ;
    rdfs:subPropertyOf biolink:node_property ;
    skos:definition "The natural logarithm of the odds ratio (OR), or the ratio of the odds of an event Y occurring in an exposed group versus the odds of an event Y occurring in a non-exposed group." ;
    skos:inScheme biolink: .

biolink:longitude a owl:DatatypeProperty ;
    rdfs:label "longitude" ;
    rdfs:range xsd:float ;
    rdfs:subPropertyOf biolink:node_property ;
    skos:definition "longitude" ;
    skos:exactMatch wgs1:long ;
    skos:inScheme biolink: .

biolink:mapped_predicate a owl:DatatypeProperty ;
    rdfs:label "mapped predicate" ;
    skos:definition "The predicate that is being replaced by the fully qualified representation of predicate + subject and object qualifiers.  Only to be used in test data and mapping data to help with the transition to the fully qualified predicate model. Not to be used in knowledge graphs." ;
    skos:inScheme biolink: .

biolink:max_research_phase a owl:ObjectProperty ;
    rdfs:label "max research phase" ;
    rdfs:range biolink:ResearchPhaseEnum ;
    rdfs:subPropertyOf biolink:association_slot ;
    skos:definition "The maximum research phase reached for a specific chemical-disease pair, indicating the highest clinical trial phase achieved for the chemical entity's investigation as a treatment for the associated disease or condition." ;
    skos:inScheme biolink: .

biolink:max_tolerated_dose a owl:DatatypeProperty ;
    rdfs:label "max tolerated dose" ;
    rdfs:range xsd:string ;
    rdfs:subPropertyOf biolink:node_property ;
    skos:definition "The highest dose of a drug or treatment that does not cause unacceptable side effects. The maximum tolerated dose is determined in clinical trials by testing increasing doses on different groups of people until the highest dose with acceptable side effects is found. Also called MTD." ;
    skos:inScheme biolink: .

biolink:narrow_match a owl:DatatypeProperty ;
    rdfs:label "narrow match" ;
    rdfs:subPropertyOf biolink:related_to_at_concept_level ;
    owl:inverseOf biolink:broad_match ;
    skos:definition "a list of terms from different schemas or terminology systems that have a narrower, more specific meaning. Narrower terms are typically shown as children in a hierarchy or tree." ;
    skos:exactMatch skos:narrowMatch,
        WIKIDATA:Q39893967 ;
    skos:inScheme biolink: ;
    biolink:opposite_of "broad match" .

biolink:narrow_synonym a owl:DatatypeProperty ;
    rdfs:label "narrow synonym" ;
    rdfs:subPropertyOf biolink:synonym ;
    skos:definition "An alternate label for an entity whose meaning is narrower (more specific) than the primary label, for example naming a particular sub-type." ;
    skos:exactMatch OIO:hasNarrowSynonym ;
    skos:inScheme biolink: .

biolink:number_of_cases a owl:DatatypeProperty ;
    rdfs:label "number of cases" ;
    rdfs:subPropertyOf biolink:has_count ;
    skos:definition "The number of cases in a study or clinical trial, primarily used in conversion of drug approval data." ;
    skos:inScheme biolink: .

biolink:object_activity_qualifier a owl:DatatypeProperty ;
    rdfs:label "object activity qualifier" ;
    rdfs:subPropertyOf biolink:process_qualifier ;
    skos:inScheme biolink: .

biolink:object_category a owl:ObjectProperty ;
    rdfs:label "object category" ;
    rdfs:domain biolink:Association ;
    rdfs:range biolink:OntologyClass ;
    rdfs:subPropertyOf biolink:association_slot ;
    skos:definition "Used to hold the biolink class/category of an association. This is a denormalized field used primarily in the SQL serialization of a knowledge graph via KGX." ;
    skos:inScheme biolink: ;
    biolink:denormalized true .

biolink:object_feature_name a owl:DatatypeProperty ;
    rdfs:label "object feature name" ;
    rdfs:subPropertyOf biolink:association_slot ;
    skos:definition "Used to describe a subordinate feature of the associated object for example, a symptom diagnosis of a disease" ;
    skos:inScheme biolink: .

biolink:object_namespace a owl:DatatypeProperty ;
    rdfs:label "object namespace" ;
    rdfs:domain biolink:Association ;
    rdfs:range xsd:string ;
    rdfs:subPropertyOf biolink:association_slot ;
    skos:altLabel "object prefix" ;
    skos:definition "Used to hold the object namespace of an association. This is a denormalized field used primarily in the SQL serialization of a knowledge graph via KGX." ;
    skos:inScheme biolink: ;
    biolink:denormalized true .

biolink:object_process_qualifier a owl:DatatypeProperty ;
    rdfs:label "object process qualifier" ;
    rdfs:subPropertyOf biolink:process_qualifier ;
    skos:inScheme biolink: .

biolink:original_object a owl:DatatypeProperty ;
    rdfs:label "original object" ;
    rdfs:subPropertyOf biolink:association_slot ;
    skos:definition "used to hold the original object of a relation (or predicate) that an external knowledge source uses before transformation to match the biolink-model specification." ;
    skos:inScheme biolink: .

biolink:original_predicate a owl:DatatypeProperty ;
    rdfs:label "original predicate" ;
    rdfs:domain biolink:Association ;
    rdfs:range xsd:anyURI ;
    rdfs:subPropertyOf biolink:association_slot ;
    skos:altLabel "original relation",
        "relation" ;
    skos:definition "used to hold the original relation/predicate that an external knowledge source uses before transformation to match the biolink-model specification." ;
    skos:inScheme biolink: .

biolink:original_subject a owl:DatatypeProperty ;
    rdfs:label "original subject" ;
    rdfs:subPropertyOf biolink:association_slot ;
    skos:definition "used to hold the original subject of a relation (or predicate) that an external knowledge source uses before transformation to match the biolink-model specification." ;
    skos:inScheme biolink: .

biolink:pAC50 a owl:ObjectProperty ;
    rdfs:label "pAC50" ;
    rdfs:range biolink:QuantityValue ;
    rdfs:subPropertyOf biolink:node_property ;
    skos:definition "pAC50 is a base 10 negative logarithmic measure of potency for an activating (agonist) interaction between a molecule (such as a drug or ligand) and a biological target (such as a receptor or enzyme), where AC50 is the concentration (in molar units) of a compound that produces 50% of its maximal activation in a functional assay." ;
    skos:inScheme biolink: .

biolink:pEC50 a owl:ObjectProperty ;
    rdfs:label "pEC50" ;
    rdfs:range biolink:QuantityValue ;
    rdfs:subPropertyOf biolink:node_property ;
    skos:definition "Negative base 10 logarithm of the molar concentration of a chemical that produces a 50% excitation of a function" ;
    skos:inScheme biolink: .

biolink:pIC50 a owl:ObjectProperty ;
    rdfs:label "pIC50" ;
    rdfs:range biolink:QuantityValue ;
    rdfs:subPropertyOf biolink:node_property ;
    skos:definition "Negative base 10 logarithm of the the inhibitory concentration 50% (IC50) measures the concentration needed to block or inhibit a biological response." ;
    skos:inScheme biolink: .

biolink:pKd a owl:ObjectProperty ;
    rdfs:label "pKd" ;
    rdfs:range biolink:QuantityValue ;
    rdfs:subPropertyOf biolink:node_property ;
    skos:definition "Negative base 10 logarithm of the equilibrium dissociation constant (KD) which is a measure of the binding affinity and is defined as the ratio of koff to kon." ;
    skos:inScheme biolink: .

biolink:pKi a owl:ObjectProperty ;
    rdfs:label "pKi" ;
    rdfs:range biolink:QuantityValue ;
    rdfs:subPropertyOf biolink:node_property ;
    skos:definition "Negative base 10 logarithm of the equilibrium binding affinity for a ligand that reduces the activity of its binding partner. Ki represents the concentration at which the inhibitor ligand occupies 50% of the receptor sites when no competing ligand is present" ;
    skos:inScheme biolink: .

biolink:pKoff a owl:ObjectProperty ;
    rdfs:label "pKoff" ;
    rdfs:range biolink:QuantityValue ;
    rdfs:subPropertyOf biolink:node_property ;
    skos:definition "Negative base 10 logarithm of the dissociation rate constant (koff) describes the rate at which they dissociate." ;
    skos:inScheme biolink: .

biolink:pKon a owl:ObjectProperty ;
    rdfs:label "pKon" ;
    rdfs:range biolink:QuantityValue ;
    rdfs:subPropertyOf biolink:node_property ;
    skos:definition "Negative base 10 logarithm of the association rate constant (Kon) describes the rate at which molecules bind to each other." ;
    skos:inScheme biolink: .

biolink:pXC50 a owl:ObjectProperty ;
    rdfs:label "pXC50" ;
    rdfs:range biolink:QuantityValue ;
    rdfs:subPropertyOf biolink:node_property ;
    skos:definition "In the context of molecular interactions and drug discovery, pXC50 is a generic, base 10 negative logarithmic measure of compound potency that unifies different types of half‑maximal concentration values into a single notation, where XC50 means “the concentration at which 50% of the maximal effect is observed”, and X is a placeholder for the type of effect being measured (e.g., inhibition or activation). The X in pXC50 is intentionally generic and can represent different assay endpoints." ;
    skos:inScheme biolink: .

biolink:phase a owl:ObjectProperty ;
    rdfs:label "phase" ;
    rdfs:domain biolink:CodingSequence ;
    rdfs:range biolink:PhaseEnum ;
    rdfs:subPropertyOf biolink:sequence_localization_attribute ;
    skos:definition "The phase for a coding sequence entity. For example, phase of a CDS as represented in a GFF3 with a value of 0, 1 or 2." ;
    skos:exactMatch gff3:phase ;
    skos:inScheme biolink: .

biolink:phenotypic_state a owl:ObjectProperty ;
    rdfs:label "phenotypic state" ;
    rdfs:range biolink:DiseaseOrPhenotypicFeature ;
    rdfs:subPropertyOf biolink:association_slot ;
    skos:definition "in experiments (e.g. gene expression) assaying diseased or unhealthy tissue, the phenotypic state can be put here, e.g. MONDO ID. For healthy tissues, use XXX." ;
    skos:inScheme biolink: .

biolink:primary_knowledge_source a owl:DatatypeProperty ;
    rdfs:label "primary knowledge source" ;
    rdfs:subPropertyOf biolink:knowledge_source ;
    skos:definition "The most upstream source of the knowledge expressed in an Association that an implementer can identify.  Performing a rigorous analysis of upstream data providers is expected; every effort is made to catalog the most upstream source of data in this property.  Only one data source should be declared primary in any association.  \"aggregator knowledge source\" can be used to capture non-primary sources." ;
    skos:editorialNote "For example: a single ChemicalToGene Edge originally curated by ClinicalTrials.org, is aggregated by ChEMBL, then incorporated into the MolePro KP, then sent via TRAPI message to the ARAGORN ARA, and finally sent to the NCATS ARS. The retrieval path for this Edge is as follows: ARS--retrieved_from-->  ARAGORN  --retrieved_from-->   MolePro  --retrieved_from--> ChEMBL --retrieved_from-->  ClinicalTrials.gov The \"primary knowledge source\" for this edge is \"infores:clinical-trials-gov\".  \"infores:chembl\" and \"infores:molecular_data_provider\" are listed in the \"aggregator knowledge source\" property." ;
    skos:inScheme biolink: .

biolink:promotes_condition a owl:ObjectProperty ;
    rdfs:label "promotes condition" ;
    rdfs:domain biolink:ChemicalOrDrugOrTreatment ;
    rdfs:range biolink:DiseaseOrPhenotypicFeature ;
    rdfs:subPropertyOf biolink:affects_likelihood_of ;
    skos:definition "Holds between a substance, procedure, or activity and a medical condition (disease or phenotypic feature), and states that the  substance, procedure, or activity is able to promote it manifesting in the first place." ;
    skos:inScheme biolink: ;
    biolink:canonical_predicate true ;
    biolink:opposite_of "preventative for condition" .

biolink:reaction_direction a owl:ObjectProperty ;
    rdfs:label "reaction direction" ;
    rdfs:range biolink:ReactionDirectionEnum ;
    rdfs:subPropertyOf biolink:association_slot ;
    skos:definition "the direction of a reaction as constrained by the direction enum (ie: left_to_right, neutral, etc.)" ;
    skos:inScheme biolink: ;
    skos:narrowMatch <http://purl.obolibrary.org/obo/NCIT_C42677> .

biolink:reaction_side a owl:ObjectProperty ;
    rdfs:label "reaction side" ;
    rdfs:range biolink:ReactionSideEnum ;
    rdfs:subPropertyOf biolink:association_slot ;
    skos:definition "the side of a reaction being modeled (ie: left or right)" ;
    skos:inScheme biolink: .

biolink:related_synonym a owl:DatatypeProperty ;
    rdfs:label "related synonym" ;
    rdfs:subPropertyOf biolink:synonym ;
    skos:definition "An alternate label that is related to the primary label but is neither exactly synonymous nor cleanly broader or narrower; useful as a lexical pointer but not for strict equivalence. Corresponds to oboInOwl:hasRelatedSynonym." ;
    skos:exactMatch OIO:hasRelatedSynonym ;
    skos:inScheme biolink: .

biolink:resource_id a owl:DatatypeProperty ;
    rdfs:label "resource id" ;
    rdfs:domain biolink:RetrievalSource ;
    rdfs:range xsd:anyURI ;
    rdfs:subPropertyOf biolink:node_property ;
    skos:definition "The CURIE for an Information Resource that served as a source of knowledge expressed in an Edge, or a source of data used to generate this knowledge." ;
    skos:inScheme biolink: .

biolink:resource_role a owl:ObjectProperty ;
    rdfs:label "resource role" ;
    rdfs:domain biolink:RetrievalSource ;
    rdfs:range biolink:ResourceRoleEnum ;
    rdfs:subPropertyOf biolink:node_property ;
    skos:definition "The role played by the InformationResource in serving as a source for an Edge. Note that a given Edge should have one and only one 'primary' source, and may have any number of 'aggregator' or 'supporting data' sources." ;
    skos:inScheme biolink: .

biolink:response_context_qualifier a owl:ObjectProperty ;
    rdfs:label "response context qualifier" ;
    rdfs:range biolink:ResponseEnum ;
    rdfs:subPropertyOf biolink:context_qualifier ;
    skos:definition "a biological response (general, study, cohort, etc.) with a specific set of characteristics to constrain an association." ;
    skos:inScheme biolink: .

biolink:response_target_context_qualifier a owl:ObjectProperty ;
    rdfs:label "response target context qualifier" ;
    rdfs:range biolink:ResponseTargetEnum ;
    rdfs:subPropertyOf biolink:context_qualifier ;
    skos:definition "a biological response target (a patient, a cohort, a model system, a cell line, a sample of biological material, etc.)" ;
    skos:inScheme biolink: .

biolink:rights a owl:DatatypeProperty ;
    rdfs:label "rights" ;
    rdfs:domain biolink:InformationContentEntity ;
    rdfs:subPropertyOf biolink:node_property ;
    skos:definition "A statement describing rights held in or over the information content entity, such as copyright, intellectual property, or access and usage rights." ;
    skos:exactMatch dct:rights ;
    skos:inScheme biolink: .

biolink:semmed_agreement_count a owl:DatatypeProperty ;
    rdfs:label "semmed agreement count" ;
    rdfs:range xsd:integer ;
    rdfs:subPropertyOf biolink:association_slot ;
    skos:definition "The number of times this concept has been asserted in the SemMedDB literature database." ;
    skos:inScheme biolink: .

biolink:source_logo a owl:DatatypeProperty ;
    rdfs:label "source logo" ;
    rdfs:domain biolink:DatasetSummary ;
    rdfs:subPropertyOf biolink:node_property ;
    skos:definition "A URL referencing an image that serves as the visual logo of a data source." ;
    skos:inScheme biolink: .

biolink:source_web_page a owl:DatatypeProperty ;
    rdfs:label "source web page" ;
    rdfs:domain biolink:DatasetSummary ;
    rdfs:subPropertyOf biolink:node_property ;
    skos:broadMatch dct:source ;
    skos:definition "A URL of a web page that documents or serves as the landing page for a data source." ;
    skos:inScheme biolink: .

biolink:start_interbase_coordinate a owl:DatatypeProperty ;
    rdfs:label "start interbase coordinate" ;
    rdfs:subPropertyOf biolink:interbase_coordinate ;
    skos:closeMatch <http://biohackathon.org/resource/faldo#begin> ;
    skos:definition "The position at which the subject nucleic acid entity starts on the chromosome or other entity to which it is located on. (ie: the start of the sequence being referenced is 0)." ;
    skos:inScheme biolink: ;
    biolink:opposite_of "end interbase coordinate" .

biolink:stoichiometry a owl:DatatypeProperty ;
    rdfs:label "stoichiometry" ;
    rdfs:range xsd:integer ;
    rdfs:subPropertyOf biolink:association_slot ;
    skos:definition "the relationship between the relative quantities of substances taking part in a reaction or forming a compound, typically a ratio of whole integers." ;
    skos:inScheme biolink: .

biolink:strand a owl:ObjectProperty ;
    rdfs:label "strand" ;
    rdfs:range biolink:StrandEnum ;
    rdfs:subPropertyOf biolink:sequence_localization_attribute ;
    skos:definition "The strand on which a feature is located. Has a value of '+' (sense strand or forward strand) or '-' (anti-sense strand or reverse strand)." ;
    skos:exactMatch gff3:strand ;
    skos:inScheme biolink: .

biolink:stringdb_coexpression_score a owl:DatatypeProperty ;
    rdfs:label "stringdb coexpression score" ;
    rdfs:range xsd:float ;
    skos:definition "A confidence score assigned by STRING representing the estimated likelihood that two proteins are functionally associated based solely on evidence that their encoding genes exhibit correlated expression patterns across one or more transcriptomic datasets. Higher scores indicate stronger support for a biological association inferred from gene co-expression." ;
    skos:inScheme <https://w3id.org/biolink/biolink-model/attributes> .

biolink:stringdb_combined_score a owl:DatatypeProperty ;
    rdfs:label "stringdb combined score" ;
    rdfs:range xsd:float ;
    skos:definition "A confidence score assigned by STRING representing the estimated likelihood that two proteins are functionally associated, based on the probabilistic integration of all available evidence channels (e.g., curated databases, experiments, co-expression, evolutionary evidence, and text mining). Higher scores indicate greater confidence in the existence of a biologically meaningful functional association." ;
    skos:inScheme <https://w3id.org/biolink/biolink-model/attributes> .

biolink:stringdb_experimental_score a owl:DatatypeProperty ;
    rdfs:label "stringdb experimental score" ;
    rdfs:range xsd:float ;
    skos:definition "A confidence score assigned by STRING representing the estimated likelihood that two proteins are functionally associated based solely on experimental evidence, including laboratory measurements of physical interactions or protein associations. Higher scores indicate stronger experimental support for a biological association between the proteins." ;
    skos:inScheme <https://w3id.org/biolink/biolink-model/attributes> .

biolink:studied_to_treat a owl:ObjectProperty ;
    rdfs:label "studied to treat" ;
    rdfs:domain biolink:ChemicalOrDrugOrTreatment ;
    rdfs:range biolink:DiseaseOrPhenotypicFeature ;
    rdfs:subPropertyOf biolink:related_to_at_instance_level,
        biolink:treats_or_applied_or_studied_to_treat ;
    skos:definition "Holds between an  substance, procedure, or activity and a medical condition, and reports that one or more scientific study has been performed to specifically test the potential of the  substance, procedure, or activity to treat the medical condition  (i.e. to ameliorate, stabilize, or cure the condition, or to delay, prevent, or reduce the risk of it manifesting in the first place)." ;
    skos:editorialNote "Predicates in this hierarchy are used in practice when a source reports performance of a study, but there is not sufficient evidence or demonstrated efficacy against the condition to warrant creating a ‘treats’ assertion edge. Note however that a 'studied to treat' edge may be used as evidence to support creation of a separate 'treats' prediction edge." ;
    skos:inScheme biolink: ;
    biolink:canonical_predicate true .

biolink:study_cohort a owl:DatatypeProperty ;
    rdfs:label "study cohort" ;
    rdfs:range xsd:string ;
    rdfs:subPropertyOf biolink:study_metadata ;
    skos:definition "A description of the study population/cohort that was interrogated by a study." ;
    skos:inScheme biolink: .

biolink:study_context a owl:DatatypeProperty ;
    rdfs:label "study context" ;
    rdfs:range xsd:string ;
    rdfs:subPropertyOf biolink:study_metadata ;
    skos:definition "A term or terms describing the experimental setting/context in which a study was carried out ('context' may be defined by many factors, including taxon, model system, tissue type, disease, etc.)." ;
    skos:inScheme biolink: .

biolink:study_date_range a owl:DatatypeProperty ;
    rdfs:label "study date range" ;
    rdfs:range xsd:string ;
    rdfs:subPropertyOf biolink:study_metadata ;
    skos:definition "The date range over which data was collected in a study." ;
    skos:inScheme biolink: .

biolink:study_method_description a owl:DatatypeProperty ;
    rdfs:label "study method description" ;
    rdfs:range xsd:anyURI ;
    rdfs:subPropertyOf biolink:study_metadata ;
    skos:definition "A uri or curie pointing to information about the methodology used to generate the data produced by a study." ;
    skos:inScheme biolink: .

biolink:study_size a owl:DatatypeProperty ;
    rdfs:label "study size" ;
    rdfs:range xsd:integer ;
    rdfs:subPropertyOf biolink:study_metadata ;
    skos:definition "The sample size used in a study (e.g. 'n' of a cohort for a clinical study)." ;
    skos:inScheme biolink: .

biolink:subject_activity_qualifier a owl:DatatypeProperty ;
    rdfs:label "subject activity qualifier" ;
    rdfs:subPropertyOf biolink:process_qualifier ;
    skos:inScheme biolink: .

biolink:subject_category a owl:ObjectProperty ;
    rdfs:label "subject category" ;
    rdfs:domain biolink:Association ;
    rdfs:range biolink:OntologyClass ;
    rdfs:subPropertyOf biolink:association_slot ;
    skos:definition "Used to hold the biolink class/category of an association. This is a denormalized field used primarily in the SQL serialization of a knowledge graph via KGX." ;
    skos:inScheme biolink: ;
    biolink:denormalized true .

biolink:subject_feature_name a owl:DatatypeProperty ;
    rdfs:label "subject feature name" ;
    rdfs:subPropertyOf biolink:association_slot ;
    skos:definition "Used to describe a subordinate feature of the associated subject for example, a particular sequence variant of a gene" ;
    skos:inScheme biolink: .

biolink:subject_namespace a owl:DatatypeProperty ;
    rdfs:label "subject namespace" ;
    rdfs:domain biolink:Association ;
    rdfs:range xsd:string ;
    rdfs:subPropertyOf biolink:association_slot ;
    skos:altLabel "subject prefix" ;
    skos:definition "Used to hold the subject namespace of an association. This is a denormalized field used primarily in the SQL serialization of a knowledge graph via KGX." ;
    skos:inScheme biolink: ;
    biolink:denormalized true .

biolink:subject_process_qualifier a owl:DatatypeProperty ;
    rdfs:label "subject process qualifier" ;
    rdfs:subPropertyOf biolink:process_qualifier ;
    skos:inScheme biolink: .

biolink:subject_specialization_qualifier a owl:DatatypeProperty ;
    rdfs:label "subject specialization qualifier" ;
    rdfs:range xsd:anyURI ;
    rdfs:subPropertyOf biolink:specialization_qualifier ;
    skos:definition "A qualifier that composes with a core subject/object concept to define a more specific version of the subject concept, specifically using an ontology term that is not a subclass or descendant of the core concept and in the vast majority of cases, is of a different ontological namespace than the category or namespace of the subject identifier." ;
    skos:inScheme biolink: .

biolink:summary a owl:DatatypeProperty ;
    rdfs:label "summary" ;
    rdfs:domain biolink:Publication ;
    rdfs:subPropertyOf biolink:node_property ;
    skos:altLabel "abstract" ;
    skos:definition "executive  summary of a publication" ;
    skos:exactMatch dct:abstract,
        WIKIDATA:Q333291 ;
    skos:inScheme biolink: .

biolink:supporting_document_type a owl:DatatypeProperty ;
    rdfs:label "supporting document type" ;
    rdfs:range xsd:string ;
    rdfs:subPropertyOf biolink:node_property ;
    skos:definition "The document type (e.g., Journal Article, Case Study, Preprint) for the supporting document used in a Text Mining Result." ;
    skos:inScheme biolink: .

biolink:supporting_document_year a owl:DatatypeProperty ;
    rdfs:label "supporting document year" ;
    rdfs:range xsd:integer ;
    rdfs:subPropertyOf biolink:node_property ;
    skos:definition "The document year (typically the publication year) for the supporting document used in a Text Mining Result." ;
    skos:inScheme biolink: .

biolink:supporting_text_section_type a owl:DatatypeProperty ;
    rdfs:label "supporting text section type" ;
    rdfs:range xsd:string ;
    rdfs:subPropertyOf biolink:node_property ;
    skos:definition "The section of the supporting text of a Text Mining Result within the supporting document. This is in the form of the name of the document section (e.g., Abstract, Introduction) that contains the supporting text." ;
    skos:inScheme biolink: .

biolink:symbol a owl:DatatypeProperty ;
    rdfs:label "symbol" ;
    rdfs:domain biolink:NamedThing ;
    rdfs:subPropertyOf biolink:node_property ;
    skos:definition "Symbol for a particular thing" ;
    skos:exactMatch gpi:DB_Object_Symbol,
        AGRKB:symbol ;
    skos:inScheme biolink: .

biolink:taxon a owl:DatatypeProperty ;
    rdfs:label "taxon" ;
    rdfs:range xsd:anyURI ;
    rdfs:subPropertyOf biolink:node_property ;
    skos:definition "A property that indicates the taxonomic classification of an entity. Values for this slot should be from the NCBITaxon ontology." ;
    skos:inScheme biolink: ;
    skos:note "Note there is also a predicate 'in taxon' that can be used to instantiate an edge between a taxon entity and a thing with taxon entity.  This is an acceptable practice for KG construction, but for many applications it is more convenient to use this property slot to directly annotate the taxon on the entity itself." .

biolink:total_sample_size a owl:DatatypeProperty ;
    rdfs:label "total sample size" ;
    rdfs:range xsd:integer ;
    rdfs:subPropertyOf biolink:dataset_count ;
    skos:definition "The total number of patients or participants within a sample population." ;
    skos:inScheme biolink: .

biolink:trade_name a owl:DatatypeProperty ;
    rdfs:label "trade name" ;
    rdfs:domain biolink:ChemicalEntity ;
    rdfs:subPropertyOf biolink:node_property ;
    skos:definition "A proprietary brand or trade name under which a chemical entity (typically a drug) is manufactured and marketed by a vendor." ;
    skos:inScheme biolink: .

biolink:treats a owl:ObjectProperty ;
    rdfs:label "treats" ;
    rdfs:domain biolink:ChemicalOrDrugOrTreatment ;
    rdfs:range biolink:DiseaseOrPhenotypicFeature ;
    rdfs:subPropertyOf biolink:treats_or_applied_or_studied_to_treat ;
    skos:altLabel "ameliorates or prevents condition",
        "indicated for",
        "is substance that treats" ;
    skos:broadMatch <http://identifiers.org/drugbank/treats>,
        <http://purl.obolibrary.org/obo/MONDO_disease_responds_to>,
        SEMMEDDB:TREATS,
        WIKIDATA_PROPERTY:P2175 ;
    skos:definition "Holds between an intervention (substance, procedure, or activity) and a medical condition (disease or phenotypic feature), and states that the intervention is, in some population(s), able to ameliorate, stabilize, or cure the condition or delay, prevent, or reduce the risk of it manifesting in the first place. ‘Treats’ edges should be asserted (knowledge_level: assertion) only in cases where there is strong supporting evidence - i.e. in some population(s) the intervention is approved for the condition, passed phase 3 or in phase 4 trials for the condition, or is an otherwise established treatment in the medical community (e.g. a widely-accepted or formally recommended off-label use). In the absence of such evidence, weaker predicates should be used in asserted edges (e.g. ‘in clinical trials for’ or ‘beneficial in models of’). ‘Treats’ edges based on weaker or indirect forms of evidence can however be created as predictions (knowledge_level: prediction) and should point to the more foundational asserted edges that support them." ;
    skos:exactMatch <http://identifiers.org/drugbank/treats>,
        WIKIDATA_PROPERTY:P2175 ;
    skos:inScheme biolink: ;
    skos:narrowMatch REPODB:clinically_tested_approved_unknown_phase,
        REPODB:clinically_tested_suspended_phase_0,
        REPODB:clinically_tested_suspended_phase_1,
        REPODB:clinically_tested_suspended_phase_1_or_phase_2,
        REPODB:clinically_tested_suspended_phase_2,
        REPODB:clinically_tested_suspended_phase_2_or_phase_3,
        REPODB:clinically_tested_suspended_phase_3,
        REPODB:clinically_tested_terminated_phase_0,
        REPODB:clinically_tested_terminated_phase_1,
        REPODB:clinically_tested_terminated_phase_1_or_phase_2,
        REPODB:clinically_tested_terminated_phase_2,
        REPODB:clinically_tested_terminated_phase_2_or_phase_3,
        REPODB:clinically_tested_terminated_phase_3,
        REPODB:clinically_tested_withdrawn_phase_0,
        REPODB:clinically_tested_withdrawn_phase_1,
        REPODB:clinically_tested_withdrawn_phase_1_or_phase_2,
        REPODB:clinically_tested_withdrawn_phase_2,
        REPODB:clinically_tested_withdrawn_phase_2_or_phase_3,
        REPODB:clinically_tested_withdrawn_phase_3,
        <http://purl.obolibrary.org/obo/NCIT_regimen_has_accepted_use_for_disease>,
        RO:0002606,
        <http://purl.obolibrary.org/obo/SNOMED_plays_role> ;
    skos:relatedMatch <http://purl.obolibrary.org/obo/MONDO_disease_responds_to> ;
    biolink:canonical_predicate true .

biolink:update_date a owl:DatatypeProperty ;
    rdfs:label "update date" ;
    rdfs:range xsd:date ;
    rdfs:subPropertyOf biolink:node_property ;
    skos:definition "date on which an entity was updated. This can be applied to nodes or edges" ;
    skos:inScheme biolink: .

biolink:z_score a owl:DatatypeProperty ;
    rdfs:label "z score" ;
    rdfs:range xsd:float ;
    rdfs:subPropertyOf biolink:association_slot ;
    skos:altLabel "normal score",
        "standard score",
        "z-score",
        "z-value" ;
    skos:definition "A measure of the divergence of an individual experimental result from the most probable result, the mean. Z is expressed in terms of the number of standard deviations from the mean value." ;
    skos:exactMatch EDAM-DATA:1668,
        <http://purl.obolibrary.org/obo/NCIT_C68741>,
        <http://purl.obolibrary.org/obo/STATO_0000104> ;
    skos:inScheme biolink: .

biolink:ActivityAndBehavior a owl:Class ;
    rdfs:label "activity and behavior" ;
    rdfs:subClassOf biolink:Occurrent ;
    skos:definition "Activity or behavior of any independent integral living, organization or mechanical actor in the world" ;
    skos:exactMatch UMLSSG:ACTI ;
    skos:inScheme biolink: .

<https://w3id.org/biolink/vocab/CausalMechanismQualifierEnum#antagonism> a owl:Class ;
    rdfs:label "antagonism" ;
    rdfs:subClassOf biolink:CausalMechanismQualifierEnum,
        <https://w3id.org/biolink/vocab/CausalMechanismQualifierEnum#inhibition> ;
    skos:closeMatch DGIdb:antagonist,
        CHEMBL.MECHANISM:antagonist ;
    skos:definition "An inhibition mechanism in which the effector binds to a receptor and prevents activation by an agonist through competing for the binding site." ;
    skos:narrowMatch CHEMBL.MECHANISM:allosteric_antagonist .

<https://w3id.org/biolink/vocab/CausalMechanismQualifierEnum#lipidation> a owl:Class ;
    rdfs:label "lipidation" ;
    rdfs:subClassOf biolink:CausalMechanismQualifierEnum,
        <https://w3id.org/biolink/vocab/CausalMechanismQualifierEnum#molecular_modification> .

<https://w3id.org/biolink/vocab/CausalMechanismQualifierEnum#ubiquitination> a owl:Class ;
    rdfs:label "ubiquitination" ;
    rdfs:subClassOf biolink:CausalMechanismQualifierEnum,
        <https://w3id.org/biolink/vocab/CausalMechanismQualifierEnum#molecular_modification> .

biolink:ChemicalEntityOrProteinOrPolypeptide a owl:Class ;
    rdfs:label "chemical entity or protein or polypeptide" ;
    rdfs:subClassOf <https://w3id.org/linkml/ClassDefinition#Mixin> ;
    skos:definition "A union of chemical entities and children, and protein and polypeptide. This mixin is helpful to use when searching across chemical entities that must include genes and their children as chemical entities." ;
    skos:inScheme biolink: .

biolink:ChemicalEntityToChemicalEntityAssociation a owl:Class ;
    rdfs:label "chemical entity to chemical entity association" ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:species_context_qualifier ],
        [ a owl:Restriction ;
            owl:minCardinality 1 ;
            owl:onProperty biolink:predicate ],
        [ a owl:Restriction ;
            owl:allValuesFrom biolink:ChemicalEntity ;
            owl:onProperty biolink:object ],
        [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:subject ],
        [ a owl:Restriction ;
            owl:allValuesFrom biolink:NamedThing ;
            owl:onProperty biolink:subject ],
        [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:predicate ],
        [ a owl:Restriction ;
            owl:allValuesFrom biolink:OrganismTaxon ;
            owl:onProperty biolink:species_context_qualifier ],
        [ a owl:Restriction ;
            owl:minCardinality 0 ;
            owl:onProperty biolink:species_context_qualifier ],
        [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:object ],
        [ a owl:Restriction ;
            owl:minCardinality 1 ;
            owl:onProperty biolink:subject ],
        [ a owl:Restriction ;
            owl:minCardinality 1 ;
            owl:onProperty biolink:object ],
        [ a owl:Restriction ;
            owl:allValuesFrom xsd:anyURI ;
            owl:onProperty biolink:predicate ],
        biolink:Association ;
    skos:definition "A relationship between two chemical entities. This can encompass actual interactions as well as temporal causal edges, e.g. one chemical converted to another." ;
    skos:inScheme biolink: .

<https://w3id.org/biolink/vocab/ChemicalOrGeneOrGeneProductFormOrVariantEnum#modified_form> a owl:Class ;
    rdfs:label "modified_form" ;
    rdfs:subClassOf biolink:ChemicalOrGeneOrGeneProductFormOrVariantEnum,
        linkml:PermissibleValue .

<https://w3id.org/biolink/vocab/ChemicalOrGeneOrGeneProductFormOrVariantEnum#non_loss_of_function_variant_form> a owl:Class ;
    rdfs:label "non_loss_of_function_variant_form" ;
    rdfs:subClassOf biolink:ChemicalOrGeneOrGeneProductFormOrVariantEnum,
        <https://w3id.org/biolink/vocab/ChemicalOrGeneOrGeneProductFormOrVariantEnum#genetic_variant_form> .

<https://w3id.org/biolink/vocab/ClinicalApprovalStatusEnum#not_approved_for_condition> a owl:Class ;
    rdfs:label "not_approved_for_condition" ;
    rdfs:subClassOf biolink:ClinicalApprovalStatusEnum,
        linkml:PermissibleValue .

biolink:ClinicalTrialAndRegulatoryApprovalContextMixin a owl:Class ;
    rdfs:label "clinical trial and regulatory approval context mixin" ;
    rdfs:subClassOf <https://w3id.org/linkml/ClassDefinition#Mixin> ;
    skos:definition "A mixin providing the clinical trial and regulatory approval context of an association between an entity (typically a chemical, drug, or treatment) and the disease or phenotypic feature it is used, or is being studied, to treat. These slots are association-scoped: they describe the entity's status with respect to this particular indication. For the entity's overall regulatory status independent of any one indication, see the node properties 'highest FDA approval status' and 'drug regulatory status world wide'." ;
    skos:inScheme biolink: .

biolink:CodingSequence a owl:Class ;
    rdfs:label "coding sequence" ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:onProperty linkml:mixins ;
            owl:someValuesFrom biolink:GenomicEntity ],
        biolink:BiologicalEntity ;
    skos:definition "A contiguous sequence which begins with, and includes, a start codon and ends with, and includes, a stop codon." ;
    skos:exactMatch <http://purl.obolibrary.org/obo/SO_0000316>,
        SIO:001390 ;
    skos:inScheme biolink: .

biolink:Device a owl:Class ;
    rdfs:label "device" ;
    rdfs:subClassOf biolink:NamedThing ;
    skos:definition "A thing made or adapted for a particular purpose, especially a piece of mechanical or electronic equipment" ;
    skos:inScheme biolink: ;
    skos:narrowMatch STY:T074,
        STY:T075,
        STY:T203,
        UMLSSG:DEVI .

biolink:DiagnosticAid a owl:Class ;
    rdfs:label "diagnostic aid" ;
    rdfs:subClassOf biolink:NamedThing ;
    skos:definition "A device or substance used to help diagnose disease or injury" ;
    skos:exactMatch STY:T130,
        <http://purl.obolibrary.org/obo/SNOMED_2949005> ;
    skos:inScheme biolink: .

biolink:DiseaseToEntityAssociationMixin a owl:Class ;
    rdfs:label "disease to entity association mixin" ;
    rdfs:subClassOf <https://w3id.org/linkml/ClassDefinition#Mixin> ;
    skos:definition "A mixin applied to any association whose subject (source node) is a disease." ;
    skos:inScheme biolink: .

biolink:DrugAvailabilityEnum a owl:Class ;
    rdfs:label "DrugAvailabilityEnum" ;
    rdfs:subClassOf linkml:EnumDefinition ;
    owl:unionOf ( <https://w3id.org/biolink/vocab/DrugAvailabilityEnum#over_the_counter> <https://w3id.org/biolink/vocab/DrugAvailabilityEnum#prescription> ) ;
    skos:definition "An enumeration describing how a drug or chemical entity may be obtained, distinguishing products that are available over the counter from those that require a prescription." ;
    skos:inScheme biolink: ;
    linkml:permissible_values <https://w3id.org/biolink/vocab/DrugAvailabilityEnum#over_the_counter>,
        <https://w3id.org/biolink/vocab/DrugAvailabilityEnum#prescription> .

biolink:EvidenceType a owl:Class ;
    rdfs:label "evidence type" ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:onProperty linkml:mixins ;
            owl:someValuesFrom biolink:OntologyClass ],
        biolink:NamedThing ;
    skos:altLabel "evidence code" ;
    skos:definition "Class of evidence that supports an association" ;
    skos:exactMatch <http://purl.obolibrary.org/obo/ECO_0000000> ;
    skos:inScheme biolink: .

biolink:Exon a owl:Class ;
    rdfs:label "exon" ;
    rdfs:subClassOf biolink:BiologicalEntity ;
    skos:definition "A region of the transcript sequence within a gene which is not removed from the primary RNA transcript by RNA splicing." ;
    skos:exactMatch <http://purl.obolibrary.org/obo/SO_0000147>,
        SIO:010445,
        WIKIDATA:Q373027 ;
    skos:inScheme biolink: .

<https://w3id.org/biolink/vocab/GeneOrGeneProductOrChemicalEntityAspectEnum#abundance> a owl:Class ;
    rdfs:label "abundance" ;
    rdfs:subClassOf biolink:GeneOrGeneProductOrChemicalEntityAspectEnum,
        <https://w3id.org/biolink/vocab/GeneOrGeneProductOrChemicalEntityAspectEnum#activity_or_abundance> .

<https://w3id.org/biolink/vocab/GeneOrGeneProductOrChemicalEntityAspectEnum#activity_or_abundance> a owl:Class ;
    rdfs:label "activity_or_abundance" ;
    rdfs:subClassOf biolink:GeneOrGeneProductOrChemicalEntityAspectEnum,
        linkml:PermissibleValue ;
    skos:definition "Used in cases where the specificity of the relationship can not be determined to be either activity or abundance.  In general, a more specific value from this enumeration should be used." .

<https://w3id.org/biolink/vocab/GeneOrGeneProductOrChemicalEntityAspectEnum#molecular_interaction> a owl:Class ;
    rdfs:label "molecular_interaction" ;
    rdfs:subClassOf biolink:GeneOrGeneProductOrChemicalEntityAspectEnum,
        linkml:PermissibleValue .

<https://w3id.org/biolink/vocab/GeneOrGeneProductOrChemicalEntityAspectEnum#transport> a owl:Class ;
    rdfs:label "transport" ;
    rdfs:subClassOf biolink:GeneOrGeneProductOrChemicalEntityAspectEnum,
        linkml:PermissibleValue .

biolink:GeneToDiseasePredicateEnum a owl:Class ;
    rdfs:label "GeneToDiseasePredicateEnum" ;
    rdfs:subClassOf linkml:EnumDefinition ;
    owl:unionOf ( <https://w3id.org/biolink/vocab/GeneToDiseasePredicateEnum#biolink%3Acontributes_to> <https://w3id.org/biolink/vocab/GeneToDiseasePredicateEnum#biolink%3Aassociated_with> <https://w3id.org/biolink/vocab/GeneToDiseasePredicateEnum#biolink%3Aaffects> ) ;
    skos:definition "Enumeration of predicates permissible for use in gene to disease associations. This constrains the relationship types that can be used between genes and diseases." ;
    skos:inScheme biolink: ;
    linkml:permissible_values <https://w3id.org/biolink/vocab/GeneToDiseasePredicateEnum#biolink%3Aaffects>,
        <https://w3id.org/biolink/vocab/GeneToDiseasePredicateEnum#biolink%3Aassociated_with>,
        <https://w3id.org/biolink/vocab/GeneToDiseasePredicateEnum#biolink%3Acontributes_to> .

biolink:LogicalInterpretationEnum a owl:Class ;
    rdfs:label "LogicalInterpretationEnum" ;
    rdfs:subClassOf linkml:EnumDefinition ;
    owl:unionOf ( os:SomeSomeInterpretation os:AllSomeInterpretation <https://w3id.org/biolink/vocab/LogicalInterpretationEnum#inverse_all_some> ) ;
    skos:definition "An enumeration of logical interpretations that can be applied to a triple to indicate whether the relation should be read as existential on both sides (some-some), universal-existential (all-some), or its inverse (inverse all-some)." ;
    skos:inScheme biolink: ;
    linkml:permissible_values os:AllSomeInterpretation,
        os:SomeSomeInterpretation,
        <https://w3id.org/biolink/vocab/LogicalInterpretationEnum#inverse_all_some> .

biolink:MacromolecularMachineToEntityAssociationMixin a owl:Class ;
    rdfs:label "macromolecular machine to entity association mixin" ;
    rdfs:subClassOf <https://w3id.org/linkml/ClassDefinition#Mixin> ;
    skos:definition "an association which has a macromolecular machine mixin as a subject" ;
    skos:inScheme biolink: .

biolink:MaterialSample a owl:Class ;
    rdfs:label "material sample" ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:onProperty linkml:mixins ;
            owl:someValuesFrom biolink:SubjectOfInvestigation ],
        biolink:PhysicalEntity ;
    skos:altLabel "biosample",
        "biospecimen",
        "physical sample",
        "sample" ;
    skos:definition "A sample is a limited quantity of something (e.g. an individual or set of individuals from a population, or a portion of a substance) to be used for testing, analysis, inspection, investigation, demonstration, or trial use. [SIO]" ;
    skos:exactMatch <http://purl.obolibrary.org/obo/OBI_0000747>,
        SIO:001050 ;
    skos:inScheme biolink: .

biolink:NoncodingRNAProduct a owl:Class ;
    rdfs:label "noncoding RNA product" ;
    rdfs:subClassOf biolink:RNAProduct ;
    skos:definition "An RNA transcript that does not encode for a protein rather the RNA molecule is the functional gene product." ;
    skos:exactMatch <http://purl.obolibrary.org/obo/SO_0000655>,
        SIO:001235 ;
    skos:inScheme biolink: .

biolink:OrganismTaxonToOrganismTaxonAssociation a owl:Class ;
    rdfs:label "organism taxon to organism taxon association" ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:object ],
        [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:subject ],
        [ a owl:Restriction ;
            owl:minCardinality 1 ;
            owl:onProperty biolink:subject ],
        [ a owl:Restriction ;
            owl:onProperty linkml:mixins ;
            owl:someValuesFrom biolink:OrganismTaxonToEntityAssociation ],
        [ owl:unionOf ( biolink:OrganismTaxonToOrganismTaxonInteraction biolink:OrganismTaxonToOrganismTaxonSpecialization ) ],
        [ a owl:Restriction ;
            owl:minCardinality 1 ;
            owl:onProperty biolink:object ],
        [ a owl:Restriction ;
            owl:allValuesFrom biolink:OrganismTaxon ;
            owl:onProperty biolink:subject ],
        [ a owl:Restriction ;
            owl:allValuesFrom biolink:OrganismTaxon ;
            owl:onProperty biolink:object ],
        biolink:Association ;
    skos:definition "A relationship between two organism taxon nodes" ;
    skos:inScheme biolink: .

biolink:PathologicalEntityMixin a owl:Class ;
    rdfs:label "pathological entity mixin" ;
    rdfs:subClassOf <https://w3id.org/linkml/ClassDefinition#Mixin> ;
    skos:definition "A pathological (abnormal) structure or process." ;
    skos:exactMatch <http://purl.obolibrary.org/obo/MPATH_0> ;
    skos:inScheme biolink: ;
    skos:narrowMatch <http://purl.obolibrary.org/obo/HP_0000118> .

biolink:Polypeptide a owl:Class ;
    rdfs:label "polypeptide" ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:onProperty linkml:mixins ;
            owl:someValuesFrom biolink:ChemicalEntityOrProteinOrPolypeptide ],
        [ a owl:Restriction ;
            owl:onProperty linkml:mixins ;
            owl:someValuesFrom biolink:ChemicalEntityOrGeneOrGeneProduct ],
        biolink:BiologicalEntity ;
    skos:altLabel "amino acid entity" ;
    skos:definition "A polypeptide is a molecular entity characterized by availability in protein databases of amino-acid-based sequence representations of its precise primary structure; for convenience of representation, partial sequences of various kinds are included, even if they do not represent a physical molecule." ;
    skos:inScheme biolink: ;
    skos:narrowMatch STY:T087,
        STY:T116,
        <http://purl.obolibrary.org/obo/SO_0000104> .

biolink:Procedure a owl:Class ;
    rdfs:label "procedure" ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:onProperty linkml:mixins ;
            owl:someValuesFrom biolink:ActivityAndBehavior ],
        biolink:NamedThing ;
    skos:definition "A series of actions conducted in a certain order or manner" ;
    skos:exactMatch dcid:MedicalProcedure,
        UMLSSG:PROC ;
    skos:inScheme biolink: ;
    skos:narrowMatch STY:T059,
        STY:T060,
        STY:T061,
        STY:T063,
        MAXO:0000001 .

biolink:RNAProduct a owl:Class ;
    rdfs:label "RNA product" ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:onProperty linkml:mixins ;
            owl:someValuesFrom biolink:GeneProductMixin ],
        biolink:Transcript ;
    skos:definition "High molecular weight, linear polymers, composed of nucleotides containing ribose and linked by phosphodiester bonds typically synthesized by a DNA- or RNA-dependent RNA polymerase that constitutes the product of a gene. Distinct in emphasis from `biolink:Transcript`, which denotes the informational output of transcription at the gene-model level rather than the chemical species itself." ;
    skos:exactMatch <http://purl.obolibrary.org/obo/CHEBI_33697>,
        WIKIDATA:Q11053 ;
    skos:inScheme biolink: .

biolink:ReactionSideEnum a owl:Class ;
    rdfs:label "ReactionSideEnum" ;
    rdfs:subClassOf linkml:EnumDefinition ;
    owl:unionOf ( <https://w3id.org/biolink/vocab/ReactionSideEnum#left> <https://w3id.org/biolink/vocab/ReactionSideEnum#right> ) ;
    skos:definition "An enumeration indicating on which side of a biochemical reaction a participant appears - the left-hand (reactant/substrate) side or the right-hand (product) side, as written." ;
    skos:inScheme biolink: ;
    linkml:permissible_values <https://w3id.org/biolink/vocab/ReactionSideEnum#left>,
        <https://w3id.org/biolink/vocab/ReactionSideEnum#right> .

biolink:RelationshipQuantifier a owl:Class ;
    rdfs:label "relationship quantifier" ;
    rdfs:subClassOf <https://w3id.org/linkml/ClassDefinition#Mixin> ;
    skos:definition "A mixin for quantifying aspects of the strength, frequency, or specificity of a relationship between two entities." ;
    skos:inScheme biolink: .

biolink:ResponseEnum a owl:Class ;
    rdfs:label "ResponseEnum" ;
    rdfs:subClassOf linkml:EnumDefinition ;
    owl:unionOf ( <https://w3id.org/biolink/vocab/ResponseEnum#therapeutic_response> <https://w3id.org/biolink/vocab/ResponseEnum#negative> ) ;
    skos:definition "A response to a treatment or intervention" ;
    skos:inScheme biolink: ;
    linkml:permissible_values <https://w3id.org/biolink/vocab/ResponseEnum#negative>,
        <https://w3id.org/biolink/vocab/ResponseEnum#therapeutic_response> .

biolink:acts_upstream_of_or_within a owl:ObjectProperty ;
    rdfs:label "acts upstream of or within" ;
    rdfs:domain biolink:GeneOrGeneProduct ;
    rdfs:range biolink:BiologicalProcess ;
    rdfs:subPropertyOf biolink:related_to_at_instance_level ;
    skos:definition "Holds between a gene or gene product and a biological process when the gene product either acts upstream of the process or participates in it; used when the more specific causal relationship is not known. Corresponds to RO:0002264." ;
    skos:exactMatch RO:0002264 ;
    skos:inScheme biolink: ;
    biolink:canonical_predicate true .

biolink:affects_likelihood_of a owl:DatatypeProperty ;
    rdfs:label "affects likelihood of" ;
    rdfs:subPropertyOf biolink:related_to_at_instance_level ;
    skos:definition "Holds between two entities where the presence or application of one alters the chance that the other will come to be." ;
    skos:editorialNote "- This predicate implies causation, where the 'affected' entity is something that does not yet exist, and the actions/execution of effector impact the likelihood that this entity may come to be. It is NOT to be used for a statistical associations that describe correlations between two feature variables (use predicates in the 'associated with likelihood of' hierarchy here.)" ;
    skos:inScheme biolink: ;
    biolink:canonical_predicate true .

biolink:aggregate_statistic a owl:DatatypeProperty ;
    rdfs:label "aggregate statistic" ;
    rdfs:subPropertyOf biolink:node_property ;
    skos:definition "An abstract grouping for summary numerical measures (e.g. count, total, quotient, percentage, rate) computed over a set of observations or a reference population, used to describe a property of an aggregated entity rather than an individual instance." ;
    skos:inScheme biolink: .

biolink:broad_match a owl:DatatypeProperty ;
    rdfs:label "broad match" ;
    rdfs:subPropertyOf biolink:related_to_at_concept_level ;
    skos:definition "a list of terms from different schemas or terminology systems that have a broader, more general meaning. Broader terms are typically shown as parents in a hierarchy or tree." ;
    skos:exactMatch skos:broadMatch,
        WIKIDATA:Q39894595 ;
    skos:inScheme biolink: ;
    biolink:canonical_predicate true ;
    biolink:opposite_of "narrow match" .

biolink:coexists_with a owl:DatatypeProperty,
        owl:SymmetricProperty ;
    rdfs:label "coexists with" ;
    rdfs:subPropertyOf biolink:related_to_at_instance_level ;
    skos:broadMatch SEMMEDDB:COEXISTS_WITH ;
    skos:definition "holds between two entities that are co-located in the same aggregate object, process, or spatio-temporal region" ;
    skos:inScheme biolink: ;
    skos:narrowMatch LOINC:has_lateral_anatomic_location,
        LOINC:has_lateral_location_presence,
        <http://purl.obolibrary.org/obo/BSPO_0000096>,
        <http://purl.obolibrary.org/obo/BSPO_0000097>,
        <http://purl.obolibrary.org/obo/BSPO_0000098>,
        <http://purl.obolibrary.org/obo/BSPO_0000099>,
        <http://purl.obolibrary.org/obo/BSPO_0000100>,
        <http://purl.obolibrary.org/obo/BSPO_0000102>,
        <http://purl.obolibrary.org/obo/BSPO_0000104>,
        <http://purl.obolibrary.org/obo/BSPO_0000110>,
        <http://purl.obolibrary.org/obo/BSPO_0000113>,
        <http://purl.obolibrary.org/obo/BSPO_0015001>,
        <http://purl.obolibrary.org/obo/BSPO_0015002>,
        <http://purl.obolibrary.org/obo/BSPO_0015003>,
        <http://purl.obolibrary.org/obo/BSPO_0015005>,
        <http://purl.obolibrary.org/obo/BSPO_0015006>,
        <http://purl.obolibrary.org/obo/BSPO_0015007>,
        <http://purl.obolibrary.org/obo/BSPO_0015008>,
        <http://purl.obolibrary.org/obo/BSPO_0015009>,
        <http://purl.obolibrary.org/obo/BSPO_0015012>,
        <http://purl.obolibrary.org/obo/BSPO_0015014>,
        <http://purl.obolibrary.org/obo/BSPO_parallel_to>,
        <http://purl.obolibrary.org/obo/ENVO_01001307>,
        FMA:adjacent_to,
        FMA:afferent_to,
        FMA:anterior_to,
        FMA:anteroinferior_to,
        FMA:anterolateral_to,
        FMA:anteromedial_to,
        FMA:anterosuperior_to,
        FMA:arterial_supply_of,
        FMA:articulates_with,
        FMA:attaches_to,
        FMA:bounded_by,
        FMA:bounds,
        FMA:branch_of,
        FMA:connection_type_of,
        FMA:continuation_branch_of,
        FMA:continuous_distally_with,
        FMA:continuous_proximally_with,
        FMA:corresponds_to,
        FMA:development_type_of,
        FMA:developmental_stage_of,
        FMA:direct_cell_shape_of,
        FMA:direct_left_of,
        FMA:direct_right_of,
        FMA:distal_to,
        FMA:drains_into,
        FMA:efferent_to,
        FMA:external_to,
        FMA:formed_by,
        FMA:forms,
        FMA:full_grown_phenotype_of,
        FMA:fuses_with,
        FMA:fusion_of,
        FMA:germ_origin_of,
        FMA:has_adherent,
        FMA:has_arterial_supply,
        FMA:has_branch,
        FMA:has_connection_type,
        FMA:has_continuation_branch,
        FMA:has_development_type,
        FMA:has_developmental_stage,
        FMA:has_direct_cell_shape,
        FMA:has_full_grown_phenotype,
        FMA:has_fusion,
        FMA:has_germ_origin,
        FMA:has_inherent_3d_shape,
        FMA:has_insertion,
        FMA:has_lymphatic_drainage,
        FMA:has_nerve_supply,
        FMA:has_observed_anatomical_entity,
        FMA:has_origin,
        FMA:has_primary_segmental_supply,
        FMA:has_projection,
        FMA:has_regional_part,
        FMA:has_related_developmental_entity,
        FMA:has_secondary_segmental_supply,
        FMA:has_segmental_composition,
        FMA:has_segmental_supply,
        FMA:has_tributary,
        FMA:has_venous_drainage,
        FMA:inferior_to,
        FMA:inferolateral_to,
        FMA:inferomedial_to,
        FMA:inherent_3d_shape_of,
        FMA:insertion_of,
        FMA:internal_to,
        FMA:lateral_to,
        FMA:left_lateral_to,
        FMA:left_medial_to,
        FMA:lymphatic_drainage_of,
        FMA:matures_from,
        FMA:matures_into,
        FMA:medial_to,
        FMA:merges_with,
        FMA:nerve_supply_of,
        FMA:origin_of,
        FMA:posterior_to,
        FMA:posteroinferior_to,
        FMA:posterolateral_to,
        FMA:posteromedial_to,
        FMA:posterosuperior_to,
        FMA:primary_segmental_supply_of,
        FMA:projects_from,
        FMA:projects_to,
        FMA:proximal_to,
        FMA:receives_attachment_from,
        FMA:receives_drainage_from,
        FMA:receives_input_from,
        FMA:receives_projection,
        FMA:related_part,
        FMA:right_lateral_to,
        FMA:right_medial_to,
        FMA:secondary_segmental_supply_of,
        FMA:segmental_composition_of,
        FMA:segmental_supply_of,
        FMA:sends_output_to,
        FMA:superior_to,
        FMA:superolateral_to,
        FMA:superomedial_to,
        FMA:surrounded_by,
        FMA:surrounds,
        FMA:tributary_of,
        FMA:venous_drainage_of,
        RO:0002219,
        RO:0002220,
        RO:0002221,
        <http://purl.obolibrary.org/obo/SO_has_origin>,
        <http://purl.obolibrary.org/obo/UBERON_anastomoses_with>,
        <http://purl.obolibrary.org/obo/UBERON_anteriorly_connected_to>,
        <http://purl.obolibrary.org/obo/UBERON_channel_for>,
        <http://purl.obolibrary.org/obo/UBERON_channels_from>,
        <http://purl.obolibrary.org/obo/UBERON_channels_into>,
        <http://purl.obolibrary.org/obo/UBERON_conduit_for>,
        <http://purl.obolibrary.org/obo/UBERON_distally_connected_to>,
        <http://purl.obolibrary.org/obo/UBERON_existence_starts_and_ends_during>,
        <http://purl.obolibrary.org/obo/UBERON_extends_fibers_into>,
        <http://purl.obolibrary.org/obo/UBERON_filtered_through>,
        <http://purl.obolibrary.org/obo/UBERON_in_central_side_of>,
        <http://purl.obolibrary.org/obo/UBERON_in_innermost_side_of>,
        <http://purl.obolibrary.org/obo/UBERON_in_outermost_side_of>,
        <http://purl.obolibrary.org/obo/UBERON_indirectly_supplies>,
        <http://purl.obolibrary.org/obo/UBERON_posteriorly_connected_to>,
        <http://purl.obolibrary.org/obo/UBERON_protects>,
        <http://purl.obolibrary.org/obo/UBERON_proximally_connected_to>,
        <http://purl.obolibrary.org/obo/UBERON_sexually_homologous_to>,
        UBERON_NONAMESPACE:distally_connected_to,
        UBERON_NONAMESPACE:subdivision_of,
        UBERON_CORE:anastomoses_with,
        UBERON_CORE:anteriorly_connected_to,
        UBERON_CORE:channel_for,
        UBERON_CORE:channels_from,
        UBERON_CORE:channels_into,
        UBERON_CORE:conduit_for,
        UBERON_CORE:distally_connected_to,
        UBERON_CORE:extends_fibers_into,
        UBERON_CORE:filtered_through,
        UBERON_CORE:indirectly_supplies,
        UBERON_CORE:posteriorly_connected_to,
        UBERON_CORE:proximally_connected_to,
        UBERON_CORE:synapsed_by,
        UBERON_CORE:transitively_anteriorly_connected_to,
        UBERON_CORE:transitively_connected_to,
        UBERON_CORE:transitively_distally_connected_to,
        UBERON_CORE:transitively_proximally_connected_to ;
    biolink:canonical_predicate true .

biolink:edges a owl:ObjectProperty ;
    rdfs:label "edges" ;
    rdfs:range biolink:Association ;
    skos:definition "A list of associations between two entities." ;
    skos:inScheme biolink: .

biolink:effect_size a owl:DatatypeProperty ;
    rdfs:label "effect size" ;
    rdfs:range xsd:float ;
    rdfs:subPropertyOf biolink:association_slot ;
    skos:definition "A quantitative measure of the magnitude and direction of an effect or association between the subject and object of an edge, as estimated by a statistical method. The specific metric used (e.g. Cohen's d, odds ratio, Pearson's r) is indicated by the companion 'effect type' slot." ;
    skos:editorialNote "The numeric value here is metric-dependent and should always be interpreted together with 'effect type'. For example, an effect size of 0.8 with effect type 'cohens_d' means a large standardized mean difference, whereas 0.8 with effect type 'pearsons_r' means a strong positive linear correlation." ;
    skos:exactMatch <http://purl.obolibrary.org/obo/STATO_0000085> ;
    skos:inScheme biolink: .

biolink:effect_type a owl:ObjectProperty ;
    rdfs:label "effect type" ;
    rdfs:range biolink:EffectTypeEnum ;
    rdfs:subPropertyOf biolink:association_slot ;
    skos:definition "Specifies the statistical metric or method used to compute the numeric value in the companion 'effect size' slot. This disambiguates the effect size value, which is otherwise uninterpretable without knowing the metric (e.g. Cohen's d vs. odds ratio vs. Pearson's r)." ;
    skos:editorialNote "This slot should only be populated when 'effect size' is also populated. Enforced via a class rule on `association`." ;
    skos:inScheme biolink: .

biolink:exact_match a owl:DatatypeProperty,
        owl:SymmetricProperty ;
    rdfs:label "exact match" ;
    rdfs:subPropertyOf biolink:close_match ;
    skos:definition "holds between two entities that have strictly equivalent meanings, with a high degree of confidence" ;
    skos:exactMatch skos:exactMatch,
        WIKIDATA:P2888,
        WIKIDATA:Q39893449 ;
    skos:inScheme biolink: ;
    biolink:canonical_predicate true .

biolink:has_contributor a owl:ObjectProperty ;
    rdfs:label "has contributor" ;
    rdfs:domain biolink:InformationContentEntity ;
    rdfs:range biolink:Agent ;
    rdfs:subPropertyOf biolink:related_to_at_instance_level ;
    owl:inverseOf biolink:contributor ;
    skos:inScheme biolink: .

biolink:has_quantitative_value a owl:ObjectProperty ;
    rdfs:label "has quantitative value" ;
    rdfs:domain biolink:Attribute ;
    rdfs:range biolink:QuantityValue ;
    skos:definition "connects an attribute to a value" ;
    skos:exactMatch qud:quantityValue ;
    skos:inScheme biolink: ;
    skos:narrowMatch <http://purl.obolibrary.org/obo/SNOMED_has_concentration_strength_numerator_value>,
        <http://purl.obolibrary.org/obo/SNOMED_has_presentation_strength_denominator_value>,
        <http://purl.obolibrary.org/obo/SNOMED_has_presentation_strength_numerator_value> .

biolink:in_taxon a owl:ObjectProperty ;
    rdfs:label "in taxon" ;
    rdfs:domain biolink:ThingWithTaxon ;
    rdfs:range biolink:OrganismTaxon ;
    rdfs:subPropertyOf biolink:related_to_at_instance_level ;
    skos:altLabel "gene found in organism",
        "gene product has organism source",
        "instance of",
        "is organism source of gene product",
        "organism has gene" ;
    skos:definition "connects an entity to its taxonomic classification. Only certain kinds of entities can be taxonomically classified; see 'thing with taxon'" ;
    skos:exactMatch RO:0002162,
        WIKIDATA_PROPERTY:P703 ;
    skos:inScheme biolink: ;
    skos:narrowMatch RO:0002160 ;
    biolink:canonical_predicate true .

biolink:interacts_with a owl:ObjectProperty,
        owl:SymmetricProperty ;
    rdfs:label "interacts with" ;
    rdfs:domain biolink:NamedThing ;
    rdfs:range biolink:NamedThing ;
    rdfs:subPropertyOf biolink:related_to_at_instance_level ;
    skos:definition "holds between any two entities that directly or indirectly interact with each other in a physical or functional way." ;
    skos:editorialNote "A note on 'interacts with' vs 'affects': These are related but separate relationships. An interaction may or may not involve one interactor exerting an effect on the other. It simply indicates that two entities participate in a physical or functional relationship (e.g. molecular binding, genetic interactions such as epistasis, or pharmacological interactions in which the combined behavior of two drugs differs from that of either drug alone). An 'effect' may be mediated by an interaction or may arise without any direct interaction, through a chain of intermediary events. Any effect or causal influence must be asserted using a predicate in the affects or causes hierarchy.",
        "Please use a more specific child predicate of interacts with, either physically interacts with or genetically interacts with or pharmacologically interacts with." ;
    skos:exactMatch SEMMEDDB:INTERACTS_WITH ;
    skos:inScheme biolink: .

biolink:nodes a owl:ObjectProperty ;
    rdfs:label "nodes" ;
    rdfs:range biolink:Entity ;
    skos:definition "A list of entities that can be a subject or object of an association" ;
    skos:inScheme biolink: .

biolink:process_qualifier a owl:DatatypeProperty ;
    rdfs:label "process qualifier" ;
    rdfs:subPropertyOf biolink:qualifier ;
    skos:definition "Restricts the biological process within which the core concept (or qualified core concept) participates." ;
    skos:inScheme biolink: .

biolink:qualifiers a owl:ObjectProperty ;
    rdfs:label "qualifiers" ;
    rdfs:range biolink:OntologyClass ;
    rdfs:subPropertyOf biolink:association_slot ;
    skos:definition "connects an association to qualifiers that modify or qualify the meaning of that association" ;
    skos:inScheme biolink: .

biolink:statistical_significance_qualifier a owl:ObjectProperty ;
    rdfs:label "statistical significance qualifier" ;
    rdfs:range biolink:StatisticalSignificanceQualifierEnum ;
    rdfs:subPropertyOf biolink:statement_qualifier ;
    skos:definition "A statement qualifier that categorizes an association's evidence by statistical significance into coarse bands, as a categorical companion to the numeric 'p value' and 'adjusted p value' slots. It applies only to assessments derived from a quantitative significance statistic (raw p-value, multiple-testing-adjusted p-value, or q-value/FDR), and MUST NOT encode ordinal study-stage, evidence-tier, or confidence-level labels (e.g. clinical trial phases) that are not statistical-significance statements." ;
    skos:editorialNote "Bands use conventional defaults (alpha = 0.05); when a source's cutoffs differ, place the value in the closest band and always also populate the numeric slot(s).",
        "Enforced via a class rule on `association`: this qualifier may only be set when 'p value' or 'adjusted p value' is also populated (the numeric slots remain authoritative)." ;
    skos:inScheme biolink: .

biolink:supporting_documents a owl:DatatypeProperty ;
    rdfs:label "supporting documents" ;
    rdfs:range xsd:anyURI ;
    rdfs:subPropertyOf biolink:association_slot ;
    skos:definition "One or more referenceable documents that report the statement expressed in an Association, or provide information used as evidence supporting this statement." ;
    skos:inScheme biolink: .

biolink:supporting_text a owl:DatatypeProperty ;
    rdfs:label "supporting text" ;
    rdfs:range xsd:string ;
    rdfs:subPropertyOf biolink:node_property ;
    skos:definition "The segment of text from a document that supports the mined assertion." ;
    skos:inScheme biolink: .

biolink:temporal_context_qualifier a owl:DatatypeProperty ;
    rdfs:label "temporal context qualifier" ;
    rdfs:range xsd:string ;
    rdfs:subPropertyOf biolink:qualifier ;
    skos:definition "a constraint of time placed upon the truth value of an association. for time intervales, use temporal interval qualifier." ;
    skos:inScheme biolink: .

biolink:AnatomicalEntityToAnatomicalEntityAssociation a owl:Class ;
    rdfs:label "anatomical entity to anatomical entity association" ;
    rdfs:subClassOf [ owl:unionOf ( biolink:AnatomicalEntityHasPartAnatomicalEntityAssociation biolink:AnatomicalEntityPartOfAnatomicalEntityAssociation biolink:AnatomicalEntityToAnatomicalEntityOntogenicAssociation ) ],
        [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:subject ],
        [ a owl:Restriction ;
            owl:minCardinality 1 ;
            owl:onProperty biolink:subject ],
        [ a owl:Restriction ;
            owl:minCardinality 1 ;
            owl:onProperty biolink:object ],
        [ a owl:Restriction ;
            owl:allValuesFrom biolink:AnatomicalEntity ;
            owl:onProperty biolink:object ],
        [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:object ],
        [ a owl:Restriction ;
            owl:allValuesFrom biolink:AnatomicalEntity ;
            owl:onProperty biolink:subject ],
        biolink:Association ;
    skos:definition "An abstract parent class for associations between two anatomical entities, such as part-of, develops-from, or other mereological and ontogenic relationships." ;
    skos:inScheme biolink: .

biolink:AssociationBasisEnum a owl:Class ;
    rdfs:label "AssociationBasisEnum" ;
    rdfs:subClassOf linkml:EnumDefinition ;
    owl:unionOf ( <https://w3id.org/biolink/vocab/AssociationBasisEnum#statistical> <https://w3id.org/biolink/vocab/AssociationBasisEnum#functional> <https://w3id.org/biolink/vocab/AssociationBasisEnum#genetic> ) ;
    skos:definition "Permissible values for the 'association basis qualifier', indicating the nature or basis of an association asserted using the 'associated with' predicate or one of its subpredicates." ;
    skos:inScheme biolink: ;
    linkml:permissible_values <https://w3id.org/biolink/vocab/AssociationBasisEnum#functional>,
        <https://w3id.org/biolink/vocab/AssociationBasisEnum#genetic>,
        <https://w3id.org/biolink/vocab/AssociationBasisEnum#statistical> .

biolink:BinaryRelationEnum a owl:Class ;
    rdfs:label "BinaryRelationEnum" ;
    rdfs:subClassOf linkml:EnumDefinition ;
    owl:unionOf ( <https://w3id.org/biolink/vocab/BinaryRelationEnum#less_than> <https://w3id.org/biolink/vocab/BinaryRelationEnum#equal_to> <https://w3id.org/biolink/vocab/BinaryRelationEnum#greater_than> ) ;
    skos:definition "Mathematical binary relation qualifiers of a value in its context." ;
    skos:inScheme biolink: ;
    linkml:permissible_values <https://w3id.org/biolink/vocab/BinaryRelationEnum#equal_to>,
        <https://w3id.org/biolink/vocab/BinaryRelationEnum#greater_than>,
        <https://w3id.org/biolink/vocab/BinaryRelationEnum#less_than> .

biolink:CaseToEntityAssociationMixin a owl:Class ;
    rdfs:label "case to entity association mixin" ;
    rdfs:subClassOf <https://w3id.org/linkml/ClassDefinition#Mixin> ;
    skos:definition "An abstract association for use where the case is the subject" ;
    skos:inScheme biolink: .

<https://w3id.org/biolink/vocab/CausalMechanismQualifierEnum#agonism> a owl:Class ;
    rdfs:label "agonism" ;
    rdfs:subClassOf biolink:CausalMechanismQualifierEnum,
        <https://w3id.org/biolink/vocab/CausalMechanismQualifierEnum#activation> ;
    skos:closeMatch DGIdb:agonist,
        CHEMBL.MECHANISM:agonist ;
    skos:definition "An activation mechanism in which the effector binds and activates a receptor to mimic the effect of an endogenous ligand." ;
    skos:narrowMatch DGIdb:partial_agonist,
        CHEMBL.MECHANISM:partial_agonist .

biolink:CellLine a owl:Class ;
    rdfs:label "cell line" ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:onProperty linkml:mixins ;
            owl:someValuesFrom biolink:SubjectOfInvestigation ],
        biolink:OrganismalEntity ;
    skos:definition "A cultured cell population that is genetically stable and homogeneous, sharing a common propagation history through successive passages in culture." ;
    skos:exactMatch <http://purl.obolibrary.org/obo/CLO_0000031> ;
    skos:inScheme biolink: .

biolink:CellularComponent a owl:Class ;
    rdfs:label "cellular component" ;
    rdfs:subClassOf biolink:AnatomicalEntity ;
    skos:altLabel "cell component",
        "cell part" ;
    skos:broadMatch WIKIDATA:P681 ;
    skos:definition "A location in or around a cell" ;
    skos:exactMatch STY:T026,
        <http://purl.obolibrary.org/obo/GO_0005575>,
        SIO:001400,
        WIKIDATA:Q5058355 ;
    skos:inScheme biolink: .

biolink:ChemicalRole a owl:Class ;
    rdfs:label "chemical role" ;
    rdfs:subClassOf biolink:Attribute ;
    skos:definition "A role played by the molecular entity or part thereof within a chemical context." ;
    skos:exactMatch <http://purl.obolibrary.org/obo/CHEBI_51086> ;
    skos:inScheme biolink: .

biolink:ClinicalIntervention a owl:Class ;
    rdfs:label "clinical intervention" ;
    rdfs:subClassOf biolink:ClinicalEntity ;
    skos:definition "A medical procedure, treatment, or action taken by healthcare professionals to modify the course of a disease or condition." ;
    skos:inScheme biolink: .

biolink:ClinicalTrialAgeStageEnum a owl:Class ;
    rdfs:label "ClinicalTrialAgeStageEnum" ;
    rdfs:subClassOf linkml:EnumDefinition ;
    owl:unionOf ( <https://w3id.org/biolink/vocab/ClinicalTrialAgeStageEnum#adult> <https://w3id.org/biolink/vocab/ClinicalTrialAgeStageEnum#child> <https://w3id.org/biolink/vocab/ClinicalTrialAgeStageEnum#older_adult> ) ;
    skos:definition "Enumeration of age stages or populations commonly used in clinical trials to categorize participant demographics and target populations." ;
    skos:inScheme biolink: ;
    linkml:permissible_values <https://w3id.org/biolink/vocab/ClinicalTrialAgeStageEnum#adult>,
        <https://w3id.org/biolink/vocab/ClinicalTrialAgeStageEnum#child>,
        <https://w3id.org/biolink/vocab/ClinicalTrialAgeStageEnum#older_adult> .

<https://w3id.org/biolink/vocab/DrugDeliveryEnum#injection> a owl:Class ;
    rdfs:label "injection" ;
    rdfs:subClassOf biolink:DrugDeliveryEnum,
        linkml:PermissibleValue .

biolink:FrequencyQuantifier a owl:Class ;
    rdfs:label "frequency quantifier" ;
    rdfs:subClassOf biolink:RelationshipQuantifier ;
    skos:definition "A relationship quantifier that expresses how often a relationship holds, using count, total, quotient, or percentage measures." ;
    skos:inScheme biolink: .

biolink:GeneFamily a owl:Class ;
    rdfs:label "gene family" ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:onProperty linkml:mixins ;
            owl:someValuesFrom biolink:ChemicalEntityOrGeneOrGeneProduct ],
        [ a owl:Restriction ;
            owl:onProperty linkml:mixins ;
            owl:someValuesFrom biolink:GeneOrGeneProductOrGeneFamily ],
        [ a owl:Restriction ;
            owl:onProperty linkml:mixins ;
            owl:someValuesFrom biolink:GeneGroupingMixin ],
        biolink:BiologicalEntity ;
    skos:altLabel "orthogroup",
        "protein family" ;
    skos:definition "any grouping of multiple genes or gene products related by common descent" ;
    skos:exactMatch <http://purl.obolibrary.org/obo/NCIT_C26004>,
        WIKIDATA:Q2278983 ;
    skos:inScheme biolink: ;
    skos:narrowMatch <http://purl.obolibrary.org/obo/NCIT_C20130>,
        SIO:001380,
        WIKIDATA:Q417841 .

biolink:GeneProductIsoformMixin a owl:Class ;
    rdfs:label "gene product isoform mixin" ;
    rdfs:subClassOf biolink:GeneProductMixin ;
    skos:definition "This is an abstract class that can be mixed in with different kinds of gene products to indicate that the gene product is intended to represent a specific isoform rather than a canonical or reference or generic product. The designation of canonical or reference may be arbitrary, or it may represent the superclass of all isoforms." ;
    skos:inScheme biolink: .

biolink:GeneToDiseaseAssociation a owl:Class ;
    rdfs:label "gene to disease association" ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:allValuesFrom biolink:GeneOrGeneProduct ;
            owl:onProperty biolink:subject ],
        [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:subject_form_or_variant_qualifier ],
        [ a owl:Restriction ;
            owl:minCardinality 0 ;
            owl:onProperty biolink:subject_form_or_variant_qualifier ],
        [ a owl:Restriction ;
            owl:minCardinality 1 ;
            owl:onProperty biolink:subject ],
        [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:diseases_confidence_score ],
        [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:allelic_requirement ],
        [ a owl:Restriction ;
            owl:allValuesFrom xsd:anyURI ;
            owl:onProperty biolink:qualified_predicate ],
        [ a owl:Restriction ;
            owl:allValuesFrom biolink:Disease ;
            owl:onProperty biolink:object ],
        [ a owl:Restriction ;
            owl:minCardinality 0 ;
            owl:onProperty biolink:diseases_confidence_score ],
        [ a owl:Restriction ;
            owl:minCardinality 0 ;
            owl:onProperty biolink:qualified_predicate ],
        [ a owl:Restriction ;
            owl:onProperty linkml:mixins ;
            owl:someValuesFrom biolink:GeneToEntityAssociationMixin ],
        [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:predicate ],
        [ a owl:Restriction ;
            owl:allValuesFrom biolink:DirectionQualifierEnum ;
            owl:onProperty biolink:object_direction_qualifier ],
        [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:subject ],
        [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:gene2phenotype_confidence_category ],
        [ a owl:Restriction ;
            owl:onProperty linkml:mixins ;
            owl:someValuesFrom biolink:EntityToDiseaseAssociationMixin ],
        [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:object ],
        [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:qualified_predicate ],
        [ a owl:Restriction ;
            owl:allValuesFrom xsd:float ;
            owl:onProperty biolink:diseases_confidence_score ],
        [ a owl:Restriction ;
            owl:allValuesFrom xsd:string ;
            owl:onProperty biolink:gene2phenotype_confidence_category ],
        [ a owl:Restriction ;
            owl:minCardinality 0 ;
            owl:onProperty biolink:gene2phenotype_confidence_category ],
        [ a owl:Restriction ;
            owl:minCardinality 0 ;
            owl:onProperty biolink:subject_aspect_qualifier ],
        [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:subject_aspect_qualifier ],
        [ a owl:Restriction ;
            owl:minCardinality 1 ;
            owl:onProperty biolink:object ],
        [ a owl:Restriction ;
            owl:allValuesFrom biolink:GeneOrGeneProductOrChemicalEntityAspectEnum ;
            owl:onProperty biolink:subject_aspect_qualifier ],
        [ a owl:Restriction ;
            owl:allValuesFrom biolink:GeneToDiseasePredicateEnum ;
            owl:onProperty biolink:predicate ],
        [ a owl:Restriction ;
            owl:allValuesFrom [ a rdfs:Datatype ;
                    owl:intersectionOf ( xsd:string [ a rdfs:Datatype ;
                                owl:onDatatype xsd:string ;
                                owl:withRestrictions ( [ xsd:pattern "^HP:\\d{7}$" ] ) ] ) ] ;
            owl:onProperty biolink:allelic_requirement ],
        [ a owl:Restriction ;
            owl:minCardinality 0 ;
            owl:onProperty biolink:object_direction_qualifier ],
        [ a owl:Restriction ;
            owl:minCardinality 0 ;
            owl:onProperty biolink:allelic_requirement ],
        [ a owl:Restriction ;
            owl:minCardinality 1 ;
            owl:onProperty biolink:predicate ],
        [ a owl:Restriction ;
            owl:allValuesFrom biolink:ChemicalOrGeneOrGeneProductFormOrVariantEnum ;
            owl:onProperty biolink:subject_form_or_variant_qualifier ],
        [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:object_direction_qualifier ],
        biolink:Association ;
    skos:closeMatch dcid:DiseaseGeneAssociation ;
    skos:definition "An association between a gene or gene product and a disease, where variation in the gene is correlated with the disease." ;
    skos:exactMatch SIO:000983 ;
    skos:inScheme biolink: ;
    skos:note "NCIT:R176 refers to the inverse relationship",
        "for use in describing the affect that the loss of function of a gene can have on exacerbating or ameliorating a disease",
        "if the relationship of the statement using this predicate is statistical in nature, please use `associated with likelihood` or one of its children." .

biolink:GeneToGeneAssociation a owl:Class ;
    rdfs:label "gene to gene association" ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:allValuesFrom biolink:GeneOrGeneProductOrChemicalEntityAspectEnum ;
            owl:onProperty biolink:subject_aspect_qualifier ],
        [ a owl:Restriction ;
            owl:allValuesFrom biolink:CausalMechanismQualifierEnum ;
            owl:onProperty biolink:causal_mechanism_qualifier ],
        [ a owl:Restriction ;
            owl:minCardinality 0 ;
            owl:onProperty biolink:causal_mechanism_qualifier ],
        [ a owl:Restriction ;
            owl:allValuesFrom biolink:DirectionQualifierEnum ;
            owl:onProperty biolink:object_direction_qualifier ],
        [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:subject_process_qualifier ],
        [ a owl:Restriction ;
            owl:allValuesFrom biolink:AnatomicalEntity ;
            owl:onProperty biolink:object_context_qualifier ],
        [ a owl:Restriction ;
            owl:minCardinality 0 ;
            owl:onProperty biolink:object_direction_qualifier ],
        [ a owl:Restriction ;
            owl:minCardinality 0 ;
            owl:onProperty biolink:subject_activity_qualifier ],
        [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:object_process_qualifier ],
        [ a owl:Restriction ;
            owl:minCardinality 0 ;
            owl:onProperty biolink:subject_process_qualifier ],
        [ a owl:Restriction ;
            owl:allValuesFrom xsd:anyURI ;
            owl:onProperty biolink:predicate ],
        [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:object_activity_qualifier ],
        [ a owl:Restriction ;
            owl:allValuesFrom biolink:GeneOrGeneProductOrChemicalEntityAspectEnum ;
            owl:onProperty biolink:object_aspect_qualifier ],
        [ a owl:Restriction ;
            owl:allValuesFrom biolink:GeneOrGeneProduct ;
            owl:onProperty biolink:object ],
        [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:subject_direction_qualifier ],
        [ a owl:Restriction ;
            owl:allValuesFrom xsd:anyURI ;
            owl:onProperty biolink:qualified_predicate ],
        [ a owl:Restriction ;
            owl:minCardinality 0 ;
            owl:onProperty biolink:object_aspect_qualifier ],
        [ a owl:Restriction ;
            owl:allValuesFrom biolink:BiologicalProcess ;
            owl:onProperty biolink:object_process_qualifier ],
        [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:predicate ],
        [ a owl:Restriction ;
            owl:minCardinality 0 ;
            owl:onProperty biolink:object_process_qualifier ],
        [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:subject_activity_qualifier ],
        [ a owl:Restriction ;
            owl:minCardinality 1 ;
            owl:onProperty biolink:subject ],
        [ a owl:Restriction ;
            owl:minCardinality 0 ;
            owl:onProperty biolink:object_context_qualifier ],
        [ a owl:Restriction ;
            owl:minCardinality 0 ;
            owl:onProperty biolink:subject_aspect_qualifier ],
        [ a owl:Restriction ;
            owl:allValuesFrom biolink:OrganismTaxon ;
            owl:onProperty biolink:species_context_qualifier ],
        [ a owl:Restriction ;
            owl:minCardinality 0 ;
            owl:onProperty biolink:qualified_predicate ],
        [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:causal_mechanism_qualifier ],
        [ a owl:Restriction ;
            owl:allValuesFrom biolink:AnatomicalEntity ;
            owl:onProperty biolink:subject_context_qualifier ],
        [ a owl:Restriction ;
            owl:minCardinality 0 ;
            owl:onProperty biolink:species_context_qualifier ],
        [ a owl:Restriction ;
            owl:minCardinality 0 ;
            owl:onProperty biolink:subject_context_qualifier ],
        [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:qualified_predicate ],
        [ a owl:Restriction ;
            owl:allValuesFrom biolink:MolecularActivity ;
            owl:onProperty biolink:object_activity_qualifier ],
        [ a owl:Restriction ;
            owl:allValuesFrom biolink:BiologicalProcess ;
            owl:onProperty biolink:subject_process_qualifier ],
        [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:species_context_qualifier ],
        [ a owl:Restriction ;
            owl:allValuesFrom biolink:DirectionQualifierEnum ;
            owl:onProperty biolink:subject_direction_qualifier ],
        [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:subject_context_qualifier ],
        [ a owl:Restriction ;
            owl:allValuesFrom biolink:MolecularActivity ;
            owl:onProperty biolink:subject_activity_qualifier ],
        [ a owl:Restriction ;
            owl:minCardinality 1 ;
            owl:onProperty biolink:object ],
        [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:subject ],
        [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:object_aspect_qualifier ],
        [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:object_context_qualifier ],
        [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:object ],
        [ a owl:Restriction ;
            owl:allValuesFrom biolink:GeneOrGeneProduct ;
            owl:onProperty biolink:subject ],
        [ a owl:Restriction ;
            owl:minCardinality 1 ;
            owl:onProperty biolink:predicate ],
        [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:object_direction_qualifier ],
        [ a owl:Restriction ;
            owl:minCardinality 0 ;
            owl:onProperty biolink:object_activity_qualifier ],
        [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:subject_aspect_qualifier ],
        [ a owl:Restriction ;
            owl:minCardinality 0 ;
            owl:onProperty biolink:subject_direction_qualifier ],
        biolink:Association ;
    skos:altLabel "molecular or genetic interaction" ;
    skos:definition "parent class for different kinds of gene-gene or gene product to gene product relationships. Includes homology and interaction." ;
    skos:inScheme biolink: .

biolink:GeneToPhenotypicFeaturePredicateEnum a owl:Class ;
    rdfs:label "GeneToPhenotypicFeaturePredicateEnum" ;
    rdfs:subClassOf linkml:EnumDefinition ;
    owl:unionOf ( <https://w3id.org/biolink/vocab/GeneToPhenotypicFeaturePredicateEnum#biolink%3Acauses> <https://w3id.org/biolink/vocab/GeneToPhenotypicFeaturePredicateEnum#biolink%3Acontributes_to> <https://w3id.org/biolink/vocab/GeneToPhenotypicFeaturePredicateEnum#biolink%3Aassociated_with> <https://w3id.org/biolink/vocab/GeneToPhenotypicFeaturePredicateEnum#biolink%3Ahas_phenotype> ) ;
    skos:definition "Enumeration of predicates permissible for use in gene to phenotypic feature associations. This constrains the relationship types that can be used between genes and phenotypic features." ;
    skos:inScheme biolink: ;
    linkml:permissible_values <https://w3id.org/biolink/vocab/GeneToPhenotypicFeaturePredicateEnum#biolink%3Aassociated_with>,
        <https://w3id.org/biolink/vocab/GeneToPhenotypicFeaturePredicateEnum#biolink%3Acauses>,
        <https://w3id.org/biolink/vocab/GeneToPhenotypicFeaturePredicateEnum#biolink%3Acontributes_to>,
        <https://w3id.org/biolink/vocab/GeneToPhenotypicFeaturePredicateEnum#biolink%3Ahas_phenotype> .

biolink:Pathway a owl:Class ;
    rdfs:label "pathway" ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:onProperty linkml:mixins ;
            owl:someValuesFrom biolink:OntologyClass ],
        biolink:BiologicalProcess ;
    skos:definition "A hierarchical ordering of connected molecular reactions (steps) that represent a specific biological process, such as signaling or metabolism." ;
    skos:exactMatch <http://purl.obolibrary.org/obo/PW_0000001>,
        WIKIDATA:Q4915012 ;
    skos:inScheme biolink: ;
    skos:narrowMatch <http://purl.obolibrary.org/obo/GO_0007165>,
        SIO:010526 .

biolink:PhaseEnum a owl:Class ;
    rdfs:label "PhaseEnum" ;
    rdfs:subClassOf linkml:EnumDefinition ;
    owl:unionOf ( <https://w3id.org/biolink/vocab/PhaseEnum#0> <https://w3id.org/biolink/vocab/PhaseEnum#1> <https://w3id.org/biolink/vocab/PhaseEnum#2> ) ;
    skos:definition "phase" ;
    skos:inScheme biolink: ;
    linkml:permissible_values <https://w3id.org/biolink/vocab/PhaseEnum#0>,
        <https://w3id.org/biolink/vocab/PhaseEnum#1>,
        <https://w3id.org/biolink/vocab/PhaseEnum#2> .

biolink:PlanetaryEntity a owl:Class ;
    rdfs:label "planetary entity" ;
    rdfs:subClassOf biolink:NamedThing ;
    skos:definition "Any entity or process that exists at the level of the whole planet" ;
    skos:inScheme biolink: .

biolink:Protein a owl:Class ;
    rdfs:label "protein" ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:onProperty linkml:mixins ;
            owl:someValuesFrom biolink:GeneProductMixin ],
        biolink:Polypeptide ;
    skos:broadMatch bioschemas:Protein ;
    skos:definition "A gene product that is composed of a chain of amino acid sequences and is produced by ribosome-mediated translation of mRNA" ;
    skos:exactMatch <http://purl.obolibrary.org/obo/PR_000000001>,
        SIO:010043,
        WIKIDATA:Q8054 ;
    skos:inScheme biolink: ;
    skos:narrowMatch STY:T126,
        STY:T192 .

biolink:RegulatoryRegion a owl:Class ;
    rdfs:label "regulatory region" ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:onProperty linkml:mixins ;
            owl:someValuesFrom biolink:GenomicEntity ],
        [ a owl:Restriction ;
            owl:onProperty linkml:mixins ;
            owl:someValuesFrom biolink:PhysicalEssence ],
        [ a owl:Restriction ;
            owl:onProperty linkml:mixins ;
            owl:someValuesFrom biolink:OntologyClass ],
        [ a owl:Restriction ;
            owl:onProperty linkml:mixins ;
            owl:someValuesFrom biolink:ChemicalEntityOrGeneOrGeneProduct ],
        biolink:BiologicalEntity ;
    skos:altLabel "regulatory element" ;
    skos:definition "A region (or regions) of the genome that contains known or putative regulatory elements that act in cis- or trans- to affect the transcription of gene" ;
    skos:exactMatch <http://purl.obolibrary.org/obo/SO_0005836>,
        SIO:001225,
        WIKIDATA:Q3238407 ;
    skos:inScheme biolink: .

biolink:ResourceRoleEnum a owl:Class ;
    rdfs:label "ResourceRoleEnum" ;
    rdfs:subClassOf linkml:EnumDefinition ;
    owl:unionOf ( <https://w3id.org/biolink/vocab/ResourceRoleEnum#primary_knowledge_source> <https://w3id.org/biolink/vocab/ResourceRoleEnum#aggregator_knowledge_source> <https://w3id.org/biolink/vocab/ResourceRoleEnum#supporting_data_source> ) ;
    skos:definition "The role played by the information reource in serving as a source for an edge in a TRAPI message. Note that a given Edge should have one and only one 'primary' source, and may have any number of 'aggregator' or 'supporting data' sources.  This enumeration is found in Biolink Model, but is repeated here for convenience." ;
    skos:inScheme biolink: ;
    linkml:permissible_values <https://w3id.org/biolink/vocab/ResourceRoleEnum#aggregator_knowledge_source>,
        <https://w3id.org/biolink/vocab/ResourceRoleEnum#primary_knowledge_source>,
        <https://w3id.org/biolink/vocab/ResourceRoleEnum#supporting_data_source> .

biolink:SequenceFeatureRelationship a owl:Class ;
    rdfs:label "sequence feature relationship" ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:minCardinality 1 ;
            owl:onProperty biolink:subject ],
        [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:subject ],
        [ a owl:Restriction ;
            owl:minCardinality 1 ;
            owl:onProperty biolink:object ],
        [ a owl:Restriction ;
            owl:allValuesFrom biolink:NucleicAcidEntity ;
            owl:onProperty biolink:object ],
        [ a owl:Restriction ;
            owl:allValuesFrom biolink:NucleicAcidEntity ;
            owl:onProperty biolink:subject ],
        [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:object ],
        biolink:Association ;
    skos:definition "For example, a particular exon is part of a particular transcript or gene" ;
    skos:exactMatch CHADO:feature_relationship ;
    skos:inScheme biolink: .

biolink:VariantToEntityAssociationMixin a owl:Class ;
    rdfs:label "variant to entity association mixin" ;
    rdfs:subClassOf <https://w3id.org/linkml/ClassDefinition#Mixin> ;
    skos:inScheme biolink: .

biolink:Zygosity a owl:Class ;
    rdfs:label "zygosity" ;
    rdfs:subClassOf biolink:Attribute ;
    skos:definition "An allelic state describing the degree of similarity between features at a single locus, specifically whether alleles at the same location on paired chromosomes are identical or different." ;
    skos:exactMatch <http://purl.obolibrary.org/obo/GENO_0000133> ;
    skos:inScheme biolink: .

biolink:adjusted_p_value a owl:DatatypeProperty ;
    rdfs:label "adjusted p value" ;
    rdfs:range xsd:float ;
    rdfs:subPropertyOf biolink:p_value ;
    skos:definition "The adjusted p-value is the probability of obtaining test results at least as extreme as the results actually observed, under the assumption that the null hypothesis is correct, adjusted for multiple comparisons. P is always italicized and capitalized. The actual P value* should be expressed (P=. 04) rather than expressing a statement of inequality (P<. 05), unless P<." ;
    skos:inScheme biolink: .

biolink:context_qualifier a owl:DatatypeProperty ;
    rdfs:label "context qualifier" ;
    rdfs:subPropertyOf biolink:qualifier ;
    skos:definition "Restricts the setting/context/location where the core concept (or qualified core concept) resides or occurs." ;
    skos:inScheme biolink: .

biolink:contributor a owl:ObjectProperty ;
    rdfs:label "contributor" ;
    rdfs:domain biolink:Agent ;
    rdfs:range biolink:InformationContentEntity ;
    rdfs:subPropertyOf biolink:related_to_at_instance_level ;
    skos:definition "Links an information content entity (such as a dataset, publication, or software artefact) to an agent responsible for making contributions to it. Used as an abstract grouping predicate over more specific contribution roles (author, editor, publisher, provider). Corresponds to dct:contributor." ;
    skos:exactMatch dct:contributor ;
    skos:inScheme biolink: ;
    skos:note "This is a grouping for predicates relating entities to their associated contributors realizing them" .

biolink:knowledge_source a owl:DatatypeProperty ;
    rdfs:label "knowledge source" ;
    rdfs:subPropertyOf biolink:association_slot ;
    skos:closeMatch pav:providedBy ;
    skos:definition "An Information Resource from which the knowledge expressed in an Association was retrieved, directly or indirectly. This can be any resource through which the knowledge passed on its way to its currently serialized form. In practice, implementers should use one of the more specific subtypes of this generic property." ;
    skos:inScheme biolink: .

biolink:p_value a owl:DatatypeProperty ;
    rdfs:label "p value" ;
    rdfs:range xsd:float ;
    rdfs:subPropertyOf biolink:association_slot ;
    skos:altLabel "unadjusted p value" ;
    skos:definition "A quantitative confidence value that represents the probability of obtaining a result at least as extreme as that actually obtained, assuming that the actual value was the result of chance alone." ;
    skos:exactMatch EDAM-DATA:1669,
        <http://purl.obolibrary.org/obo/NCIT_C44185>,
        <http://purl.obolibrary.org/obo/OBI_0000175> ;
    skos:inScheme biolink: .

biolink:part_of a owl:DatatypeProperty ;
    rdfs:label "part of" ;
    rdfs:subPropertyOf biolink:overlaps ;
    owl:inverseOf biolink:has_part ;
    skos:broadMatch RXNORM:contained_in,
        FMA:contained_in,
        RO:0001018 ;
    skos:definition "holds between parts and wholes (material entities or processes)" ;
    skos:exactMatch RXNORM:constitutes,
        RXNORM:part_of,
        <http://purl.obolibrary.org/obo/BFO_0000050>,
        FMA:part_of,
        SEMMEDDB:PART_OF,
        WIKIDATA_PROPERTY:P361 ;
    skos:inScheme biolink: ;
    skos:narrowMatch <http://identifiers.org/drugbank/component_of>,
        <http://identifiers.org/meddra/member_of>,
        <http://identifiers.org/umls/component_of>,
        <http://identifiers.org/umls/has_owning_affiliate>,
        <http://identifiers.org/umls/owning_subsection_of>,
        LOINC:component_of,
        LOINC:has_supersystem,
        LOINC:member_of,
        LOINC:multipart_of,
        NDDF:ingredient_of,
        RXNORM:ingredient_of,
        RXNORM:ingredients_of,
        RXNORM:precise_ingredient_of,
        <http://purl.obolibrary.org/obo/BSPO_0001106>,
        <http://purl.obolibrary.org/obo/BSPO_0001108>,
        <http://purl.obolibrary.org/obo/BSPO_0001113>,
        <http://purl.obolibrary.org/obo/BSPO_0001115>,
        <http://purl.obolibrary.org/obo/CHEBI_is_substituent_group_from>,
        FMA:constitutional_part_of,
        FMA:member_of,
        FMA:regional_part_of,
        FMA:related_developmental_entity_of,
        <http://purl.obolibrary.org/obo/MONDO_part_of_progression_of_disease>,
        <http://purl.obolibrary.org/obo/NCIT_R27>,
        <http://purl.obolibrary.org/obo/NCIT_R82>,
        <http://purl.obolibrary.org/obo/NCIT_is_component_of_chemotherapy_regimen>,
        RO:0002007,
        RO:0002350,
        RO:0002376,
        RO:0002380,
        RO:0002571,
        RO:0002572,
        RO:0002576,
        <http://purl.obolibrary.org/obo/SNOMED_active_ingredient_of>,
        <http://purl.obolibrary.org/obo/SNOMED_basis_of_strength_substance_of>,
        <http://purl.obolibrary.org/obo/SNOMED_component_of>,
        <http://purl.obolibrary.org/obo/SNOMED_direct_substance_of>,
        <http://purl.obolibrary.org/obo/SNOMED_during>,
        <http://purl.obolibrary.org/obo/SNOMED_focus_of>,
        <http://purl.obolibrary.org/obo/SNOMED_has_dependent>,
        <http://purl.obolibrary.org/obo/SNOMED_part_anatomy_structure_of>,
        <http://purl.obolibrary.org/obo/SNOMED_precise_active_ingredient_of>,
        <http://purl.obolibrary.org/obo/UBERON_subdivision_of>,
        UBERON_CORE:layer_part_of,
        UBERON_CORE:subdivision_of,
        UBERON_CORE:trunk_part_of,
        CPT:panel_element_of,
        CPT:panel_element_of_possibly_included,
        VANDF:ingredient_of .

biolink:sequence_localization_attribute a owl:DatatypeProperty ;
    rdfs:label "sequence localization attribute" ;
    rdfs:domain biolink:GenomicSequenceLocalization ;
    rdfs:subPropertyOf biolink:association_slot ;
    skos:definition "An attribute that can be applied to a genome sequence localization edge. These edges connect a nucleic acid entity such as an exon to an entity such as a chromosome. Edge properties are used to ascribe specific positional information and other metadata to the localization. In pragmatic terms this can be thought of as columns in a GFF3 line." ;
    skos:inScheme biolink: .

<https://w3id.org/biolink/vocab/AgentTypeEnum#automated_agent> a owl:Class ;
    rdfs:label "automated_agent" ;
    rdfs:subClassOf biolink:AgentTypeEnum,
        linkml:PermissibleValue ;
    skos:definition "An automated agent, typically a software program or tool, that is responsible for generating a statement of knowledge. Human contribution to the knowledge creation process ends with the definition and coding of algorithms or analysis pipelines that get executed by the automated agent." .

<https://w3id.org/biolink/vocab/CausalMechanismQualifierEnum#covalent_binding> a owl:Class ;
    rdfs:label "covalent_binding" ;
    rdfs:subClassOf biolink:CausalMechanismQualifierEnum,
        <https://w3id.org/biolink/vocab/CausalMechanismQualifierEnum#modulation> ;
    skos:definition "A modulation mechanism mediated by a direct covalent binding interaction between effector and target chemical or biomolecular entity." .

<https://w3id.org/biolink/vocab/CausalMechanismQualifierEnum#positive_modulation> a owl:Class ;
    rdfs:label "positive_modulation" ;
    rdfs:subClassOf biolink:CausalMechanismQualifierEnum,
        <https://w3id.org/biolink/vocab/CausalMechanismQualifierEnum#modulation> ;
    skos:definition "A modulation mechanism that positively effects the normal functioning of a target by increasing or enhancing its activity or abundance, or its sensitivity to other factors that do so." .

biolink:ChemicalEntityDerivativeEnum a owl:Class ;
    rdfs:label "ChemicalEntityDerivativeEnum" ;
    rdfs:subClassOf linkml:EnumDefinition ;
    skos:definition "An enumeration of relationships by which one chemical entity is derived from another, e.g., a metabolite produced from a parent compound." ;
    skos:inScheme biolink: ;
    linkml:permissible_values <https://w3id.org/biolink/vocab/ChemicalEntityDerivativeEnum#metabolite> .

<https://w3id.org/biolink/vocab/ChemicalOrGeneOrGeneProductFormOrVariantEnum#genetic_variant_form> a owl:Class ;
    rdfs:label "genetic_variant_form" ;
    rdfs:subClassOf biolink:ChemicalOrGeneOrGeneProductFormOrVariantEnum,
        <https://w3id.org/biolink/vocab/ChemicalOrGeneOrGeneProductFormOrVariantEnum#modified_form> .

biolink:ClinicalAttribute a owl:Class ;
    rdfs:label "clinical attribute" ;
    rdfs:subClassOf biolink:Attribute ;
    skos:definition "Attributes relating to a clinical manifestation" ;
    skos:exactMatch STY:T201 ;
    skos:inScheme biolink: .

biolink:DatasetDistribution a owl:Class ;
    rdfs:label "dataset distribution" ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:minCardinality 0 ;
            owl:onProperty biolink:distribution_download_url ],
        [ a owl:Restriction ;
            owl:allValuesFrom xsd:string ;
            owl:onProperty biolink:distribution_download_url ],
        [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:distribution_download_url ],
        biolink:InformationContentEntity ;
    skos:definition "an item that holds distribution level information about a dataset." ;
    skos:exactMatch dcat:Distribution ;
    skos:inScheme biolink: .

biolink:DatasetSummary a owl:Class ;
    rdfs:label "dataset summary" ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:allValuesFrom xsd:string ;
            owl:onProperty biolink:source_web_page ],
        [ a owl:Restriction ;
            owl:allValuesFrom xsd:string ;
            owl:onProperty biolink:source_logo ],
        [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:source_web_page ],
        [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:source_logo ],
        [ a owl:Restriction ;
            owl:minCardinality 0 ;
            owl:onProperty biolink:source_web_page ],
        [ a owl:Restriction ;
            owl:minCardinality 0 ;
            owl:onProperty biolink:source_logo ],
        biolink:InformationContentEntity ;
    skos:definition "an item that holds summary level information about a dataset." ;
    skos:inScheme biolink: .

biolink:DruggableGeneCategoryEnum a owl:Class ;
    rdfs:label "DruggableGeneCategoryEnum" ;
    rdfs:subClassOf linkml:EnumDefinition ;
    owl:unionOf ( <https://w3id.org/biolink/vocab/DruggableGeneCategoryEnum#tclin> <https://w3id.org/biolink/vocab/DruggableGeneCategoryEnum#tbio> <https://w3id.org/biolink/vocab/DruggableGeneCategoryEnum#tchem> <https://w3id.org/biolink/vocab/DruggableGeneCategoryEnum#tdark> ) ;
    skos:definition "An enumeration of druggability categories for gene targets as defined by the IDG (Illuminating the Druggable Genome) / Pharos target development level classification: Tclin (targets of approved drugs), Tchem (targets with potent bioactives), Tbio (targets with biological knowledge), and Tdark (poorly characterized targets)." ;
    skos:inScheme biolink: ;
    linkml:permissible_values <https://w3id.org/biolink/vocab/DruggableGeneCategoryEnum#tbio>,
        <https://w3id.org/biolink/vocab/DruggableGeneCategoryEnum#tchem>,
        <https://w3id.org/biolink/vocab/DruggableGeneCategoryEnum#tclin>,
        <https://w3id.org/biolink/vocab/DruggableGeneCategoryEnum#tdark> .

<https://w3id.org/biolink/vocab/EffectTypeEnum#standardized_mean_difference> a owl:Class ;
    rdfs:label "standardized_mean_difference" ;
    rdfs:subClassOf biolink:EffectTypeEnum,
        linkml:PermissibleValue ;
    skos:closeMatch <http://purl.obolibrary.org/obo/STATO_0000100> ;
    skos:definition "The difference between two group means divided by a pooled standard deviation, used when the predictor is categorical and the outcome is continuous." .

biolink:FDAIDAAdverseEventEnum a owl:Class ;
    rdfs:label "FDAIDAAdverseEventEnum" ;
    rdfs:subClassOf linkml:EnumDefinition ;
    owl:unionOf ( <https://w3id.org/biolink/vocab/FDAIDAAdverseEventEnum#life_threatening_adverse_event> <https://w3id.org/biolink/vocab/FDAIDAAdverseEventEnum#serious_adverse_event> <https://w3id.org/biolink/vocab/FDAIDAAdverseEventEnum#suspected_adverse_reaction> <https://w3id.org/biolink/vocab/FDAIDAAdverseEventEnum#unexpected_adverse_event> ) ;
    skos:definition "please consult with the FDA guidelines as proposed in this document: https://www.accessdata.fda.gov/scripts/cdrh/cfdocs/cfcfr/cfrsearch.cfm?fr=312.32" ;
    skos:inScheme biolink: ;
    linkml:permissible_values <https://w3id.org/biolink/vocab/FDAIDAAdverseEventEnum#life_threatening_adverse_event>,
        <https://w3id.org/biolink/vocab/FDAIDAAdverseEventEnum#serious_adverse_event>,
        <https://w3id.org/biolink/vocab/FDAIDAAdverseEventEnum#suspected_adverse_reaction>,
        <https://w3id.org/biolink/vocab/FDAIDAAdverseEventEnum#unexpected_adverse_event> .

biolink:FrequencyQualifierMixin a owl:Class ;
    rdfs:label "frequency qualifier mixin" ;
    rdfs:subClassOf <https://w3id.org/linkml/ClassDefinition#Mixin> ;
    skos:definition "Qualifier for frequency type associations" ;
    skos:inScheme biolink: .

biolink:FunctionalAssociation a owl:Class ;
    rdfs:label "functional association" ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:allValuesFrom biolink:OntologyClass ;
            owl:onProperty biolink:object ],
        [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:object ],
        [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:subject ],
        [ a owl:Restriction ;
            owl:minCardinality 1 ;
            owl:onProperty biolink:object ],
        [ a owl:Restriction ;
            owl:minCardinality 1 ;
            owl:onProperty biolink:subject ],
        [ a owl:Restriction ;
            owl:allValuesFrom biolink:MacromolecularMachineMixin ;
            owl:onProperty biolink:subject ],
        biolink:Association ;
    skos:definition "An association between a macromolecular machine mixin (gene, gene product or complex of gene products) and either a molecular activity, a biological process or a cellular location in which a function is executed." ;
    skos:inScheme biolink: .

biolink:GeneGroupingMixin a owl:Class ;
    rdfs:label "gene grouping mixin" ;
    rdfs:subClassOf <https://w3id.org/linkml/ClassDefinition#Mixin> ;
    skos:definition "any grouping of multiple genes or gene products" ;
    skos:inScheme biolink: .

biolink:GeneOrGeneProductOrGeneFamily a owl:Class ;
    rdfs:label "gene or gene product or gene family" ;
    rdfs:subClassOf biolink:MacromolecularMachineMixin ;
    skos:definition "A union of gene family or gene loci or gene products, useful to define the association between a gene or gene product or gene family and some other general class of entity." ;
    skos:inScheme biolink: .

biolink:IndividualOrganism a owl:Class ;
    rdfs:label "individual organism" ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:onProperty linkml:mixins ;
            owl:someValuesFrom biolink:SubjectOfInvestigation ],
        biolink:OrganismalEntity ;
    skos:altLabel "organism" ;
    skos:definition "An instance of an organism. For example, Charles Darwin, my pet cat." ;
    skos:exactMatch STY:T001,
        SIO:010000 ;
    skos:inScheme biolink: ;
    skos:narrowMatch foaf:Person,
        WIKIDATA:Q795052 .

biolink:LifeStage a owl:Class ;
    rdfs:label "life stage" ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:onProperty linkml:mixins ;
            owl:someValuesFrom biolink:OntologyClass ],
        biolink:OrganismalEntity ;
    skos:definition "A stage of development or growth of an organism, including post-natal adult stages" ;
    skos:exactMatch <http://purl.obolibrary.org/obo/UBERON_0000105> ;
    skos:inScheme biolink: ;
    skos:narrowMatch HsapDv:0000000 .

biolink:ModelToDiseaseAssociationMixin a owl:Class ;
    rdfs:label "model to disease association mixin" ;
    rdfs:subClassOf <https://w3id.org/linkml/ClassDefinition#Mixin> ;
    skos:definition "This mixin is used for any association class for which the subject (source node) plays the role of a 'model', in that it recapitulates some features of the disease in a way that is useful for studying the disease outside a patient carrying the disease" ;
    skos:inScheme biolink: .

biolink:Onset a owl:Class ;
    rdfs:label "onset" ;
    rdfs:subClassOf biolink:ClinicalCourse ;
    skos:definition "The age group in which (disease) symptom manifestations appear." ;
    skos:editorialNote "This class is in Biolink to support HP ontology annotations which use \"onset\" (with terms from HP) as an annotation on a disease to phenotypic feature association.  This should be the primary use case for this class." ;
    skos:exactMatch <http://purl.obolibrary.org/obo/HP_0003674> ;
    skos:inScheme biolink: .

biolink:PhysicalEntity a owl:Class ;
    rdfs:label "physical entity" ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:onProperty linkml:mixins ;
            owl:someValuesFrom biolink:PhysicalEssence ],
        biolink:NamedThing ;
    skos:definition "An entity that has material reality (a.k.a. physical essence)." ;
    skos:exactMatch STY:T072 ;
    skos:inScheme biolink: ;
    skos:narrowMatch STY:T073 .

biolink:ReactionDirectionEnum a owl:Class ;
    rdfs:label "ReactionDirectionEnum" ;
    rdfs:subClassOf linkml:EnumDefinition ;
    owl:unionOf ( <https://w3id.org/biolink/vocab/ReactionDirectionEnum#left_to_right> <https://w3id.org/biolink/vocab/ReactionDirectionEnum#right_to_left> <https://w3id.org/biolink/vocab/ReactionDirectionEnum#bidirectional> <https://w3id.org/biolink/vocab/ReactionDirectionEnum#neutral> ) ;
    skos:definition "An enumeration of possible directions for a biochemical reaction, indicating whether it proceeds left-to-right, right-to-left, is bidirectional (reversible), or has no net direction." ;
    skos:inScheme biolink: ;
    linkml:permissible_values <https://w3id.org/biolink/vocab/ReactionDirectionEnum#bidirectional>,
        <https://w3id.org/biolink/vocab/ReactionDirectionEnum#left_to_right>,
        <https://w3id.org/biolink/vocab/ReactionDirectionEnum#neutral>,
        <https://w3id.org/biolink/vocab/ReactionDirectionEnum#right_to_left> .

biolink:ResponseTargetEnum a owl:Class ;
    rdfs:label "ResponseTargetEnum" ;
    rdfs:subClassOf linkml:EnumDefinition ;
    owl:unionOf ( <https://w3id.org/biolink/vocab/ResponseTargetEnum#cohort> <https://w3id.org/biolink/vocab/ResponseTargetEnum#cell%20line> <https://w3id.org/biolink/vocab/ResponseTargetEnum#individual> <https://w3id.org/biolink/vocab/ResponseTargetEnum#sample> ) ;
    skos:definition "The target of a treatment or intervention" ;
    skos:inScheme biolink: ;
    linkml:permissible_values <https://w3id.org/biolink/vocab/ResponseTargetEnum#cell%20line>,
        <https://w3id.org/biolink/vocab/ResponseTargetEnum#cohort>,
        <https://w3id.org/biolink/vocab/ResponseTargetEnum#individual>,
        <https://w3id.org/biolink/vocab/ResponseTargetEnum#sample> .

biolink:affected_by a owl:DatatypeProperty ;
    rdfs:label "affected by" ;
    rdfs:subPropertyOf biolink:related_to_at_instance_level ;
    owl:inverseOf biolink:affects ;
    skos:definition "describes an entity of which the state or quality is affected by another existing entity." ;
    skos:inScheme biolink: .

biolink:correlated_with a owl:ObjectProperty,
        owl:SymmetricProperty ;
    rdfs:label "correlated with" ;
    rdfs:domain biolink:NamedThing ;
    rdfs:range biolink:NamedThing ;
    rdfs:subPropertyOf biolink:associated_with ;
    skos:definition "A relationship that holds between two concepts represented by variables for which a statistical correlation is believed to exist, as demonstrated using a correlation analysis method." ;
    skos:editorialNote "These concepts may map exactly to the statistical variables, or represent related entities for which the variables serve as proxies in an Association (e.g. diseases, chemical entities or processes). Note also that this predicate can be used in the absence of a direct statistical analysis, if there is other evidence suggesting that a correlation is likely to exist." ;
    skos:exactMatch <http://purl.obolibrary.org/obo/PATO_correlates_with>,
        RO:0002610 ;
    skos:inScheme biolink: ;
    biolink:canonical_predicate true .

biolink:creation_date a owl:DatatypeProperty ;
    rdfs:label "creation date" ;
    rdfs:range xsd:date ;
    rdfs:subPropertyOf biolink:node_property ;
    skos:altLabel "date started",
        "publication date" ;
    skos:definition "date on which an entity was created. This can be applied to nodes or edges" ;
    skos:exactMatch dct:createdOn,
        WIKIDATA_PROPERTY:P577 ;
    skos:inScheme biolink: .

biolink:dgidb_evidence_score a owl:DatatypeProperty ;
    rdfs:label "dgidb evidence score" ;
    rdfs:range xsd:integer ;
    skos:definition "A score defined by DGIdb that is used to report the amount of evidence supporting a given interaction statement, which is simply the sum of all supporting sources and publications. See https://dgidb.org/about/overview/interaction-score." ;
    skos:inScheme <https://w3id.org/biolink/biolink-model/attributes> .

biolink:dgidb_interaction_score a owl:DatatypeProperty ;
    rdfs:label "dgidb interaction score" ;
    rdfs:range xsd:float ;
    skos:definition "A score defined by DGIdb that is used to rank interaction record results in DGIdb, which  combines their evidence score  (based on total supporting sources and pubs), with their relative gene specificity score and relative drug specificity score. See https://dgidb.org/about/overview/interaction-score." ;
    skos:inScheme <https://w3id.org/biolink/biolink-model/attributes> .

biolink:diseases_confidence_score a owl:DatatypeProperty ;
    rdfs:label "diseases confidence score" ;
    rdfs:range xsd:float ;
    skos:definition "A score defined by Jensen Lab Diseases that reports confidence level in an association on a scale of 1-5 stars.  It is based on different inputs for curated knowledge associations vs text-mined associations vs experimental/GWAS based associations, but adjusts/caps scores for these types of knowledge such that they are comparable on a single scale." ;
    skos:inScheme <https://w3id.org/biolink/biolink-model/attributes> .

biolink:enabled_by a owl:ObjectProperty ;
    rdfs:label "enabled by" ;
    rdfs:domain biolink:BiologicalProcessOrActivity ;
    rdfs:range biolink:PhysicalEntity ;
    rdfs:subPropertyOf biolink:has_participant ;
    owl:inverseOf biolink:enables ;
    skos:definition "holds between a process and a physical entity, where the physical entity executes the process" ;
    skos:exactMatch RO:0002333 ;
    skos:inScheme biolink: ;
    biolink:opposite_of "prevented by" .

biolink:has_attribute_type a owl:ObjectProperty ;
    rdfs:label "has attribute type" ;
    rdfs:domain biolink:Attribute ;
    rdfs:range biolink:OntologyClass ;
    skos:definition "connects an attribute to a class that describes it" ;
    skos:inScheme biolink: ;
    skos:narrowMatch LOINC:has_modality_type,
        LOINC:has_view_type .

biolink:has_part a owl:DatatypeProperty ;
    rdfs:label "has part" ;
    rdfs:subPropertyOf biolink:overlaps ;
    skos:broadMatch RXNORM:contains,
        FMA:contains,
        RO:0001019 ;
    skos:definition "holds between wholes and their parts (material entities or processes)" ;
    skos:exactMatch RXNORM:consists_of,
        RXNORM:has_part,
        <http://purl.obolibrary.org/obo/BFO_0000051>,
        <http://purl.obolibrary.org/obo/BFO_0000055>,
        RO:0001019,
        WIKIDATA_PROPERTY:P527 ;
    skos:inScheme biolink: ;
    skos:narrowMatch <http://identifiers.org/meddra/has_member>,
        <http://identifiers.org/umls/has_component>,
        LOINC:has_component,
        LOINC:has_member,
        NDDF:has_ingredient,
        RXNORM:has_ingredient,
        <http://purl.obolibrary.org/obo/BFO_0000117>,
        FMA:has_constitutional_part,
        FMA:has_member,
        FMA:has_part,
        <http://purl.obolibrary.org/obo/FOODON_00001563>,
        <http://purl.obolibrary.org/obo/FOODON_00002420>,
        <http://purl.obolibrary.org/obo/MONDO_disease_has_major_feature>,
        <http://purl.obolibrary.org/obo/NCIT_R50>,
        <http://purl.obolibrary.org/obo/NCIT_complex_has_physical_part>,
        RO:0002104,
        RO:0002180,
        RO:0002351,
        RO:0002473,
        RO:0002524,
        RO:0002551,
        <http://purl.obolibrary.org/obo/SNOMED_has_component>,
        PathWhiz:has_element_in_bound,
        PathWhiz:has_protein_in_complex ;
    biolink:canonical_predicate true ;
    biolink:opposite_of "lacks part" .

biolink:has_quotient a owl:DatatypeProperty ;
    rdfs:label "has quotient" ;
    rdfs:range xsd:double ;
    rdfs:subPropertyOf biolink:aggregate_statistic ;
    skos:inScheme biolink: .

biolink:has_total a owl:DatatypeProperty ;
    rdfs:label "has total" ;
    rdfs:range xsd:integer ;
    rdfs:subPropertyOf biolink:aggregate_statistic ;
    skos:definition "total number of things in a particular reference set" ;
    skos:inScheme biolink: .

biolink:has_zygosity a owl:ObjectProperty ;
    rdfs:label "has zygosity" ;
    rdfs:domain biolink:NucleicAcidEntity ;
    rdfs:range biolink:Zygosity ;
    rdfs:subPropertyOf biolink:node_property ;
    skos:definition "The zygosity characterising a genotype or nucleic acid entity at a particular locus." ;
    skos:inScheme biolink: .

biolink:iri a owl:DatatypeProperty ;
    rdfs:label "iri" ;
    rdfs:range xsd:string ;
    skos:definition "An IRI for an entity. This is determined by the id using expansion rules." ;
    skos:exactMatch WIKIDATA_PROPERTY:P854 ;
    skos:inScheme biolink: .

biolink:iso_abbreviation a owl:DatatypeProperty ;
    rdfs:label "iso abbreviation" ;
    rdfs:domain biolink:Publication ;
    rdfs:subPropertyOf biolink:node_property ;
    skos:definition "Standard abbreviation for periodicals in the International Organization for Standardization (ISO) 4 system See https://www.issn.org/services/online-services/access-to-the-ltwa/. If the 'published in' property is set, then the iso abbreviation pertains to the broader publication context (the journal) within which the given publication node is embedded, not the publication itself." ;
    skos:exactMatch WIKIDATA_PROPERTY:P1160 ;
    skos:inScheme biolink: .

biolink:issue a owl:DatatypeProperty ;
    rdfs:label "issue" ;
    rdfs:domain biolink:Publication ;
    rdfs:subPropertyOf biolink:node_property ;
    skos:definition "issue of a newspaper, a scientific journal or magazine for reference purpose" ;
    skos:exactMatch WIKIDATA_PROPERTY:P433 ;
    skos:inScheme biolink: .

biolink:negated a owl:DatatypeProperty ;
    rdfs:label "negated" ;
    rdfs:range xsd:boolean ;
    rdfs:subPropertyOf biolink:association_slot ;
    skos:definition "if set to true, then the association is negated i.e. is not true" ;
    skos:inScheme biolink: .

biolink:object_specialization_qualifier a owl:DatatypeProperty ;
    rdfs:label "object specialization qualifier" ;
    rdfs:range xsd:anyURI ;
    rdfs:subPropertyOf biolink:specialization_qualifier ;
    skos:definition "A qualifier that composes with a core subject/object concept to define a more specific version of the subject concept, specifically using an ontology term that is not a subclass or descendant of the core concept and in the vast majority of cases, is of a different ontological namespace than the category or namespace of the subject identifier." ;
    skos:inScheme biolink: .

biolink:participates_in a owl:ObjectProperty ;
    rdfs:label "participates in" ;
    rdfs:domain biolink:Occurrent ;
    rdfs:range biolink:BiologicalProcessOrActivity ;
    rdfs:subPropertyOf biolink:related_to_at_instance_level ;
    owl:inverseOf biolink:has_participant ;
    skos:definition "holds between a continuant and a process, where the continuant is somehow involved in the process" ;
    skos:exactMatch <http://purl.obolibrary.org/obo/BFO_0000056>,
        RO:0000056 ;
    skos:inScheme biolink: ;
    skos:narrowMatch <http://identifiers.org/drugbank/pathway>,
        <http://identifiers.org/hmdb/in_pathway>,
        LOINC:is_given_pharmaceutical_substance_for,
        <http://purl.obolibrary.org/obo/NCIT_R130>,
        <http://purl.obolibrary.org/obo/NCIT_R131>,
        <http://purl.obolibrary.org/obo/NCIT_R37>,
        <http://purl.obolibrary.org/obo/NCIT_R51>,
        <http://purl.obolibrary.org/obo/NCIT_R53>,
        <http://purl.obolibrary.org/obo/OBI_0000295>,
        RO:0002216,
        RO:0002505,
        <http://purl.obolibrary.org/obo/SNOMED_has_direct_device> .

biolink:published_in a owl:DatatypeProperty ;
    rdfs:label "published in" ;
    rdfs:domain biolink:Publication ;
    rdfs:range xsd:anyURI ;
    rdfs:subPropertyOf biolink:node_property ;
    skos:definition "CURIE identifier of a broader publication context within which the publication may be placed." ;
    skos:exactMatch WIKIDATA_PROPERTY:P1433 ;
    skos:inScheme biolink: .

biolink:quantifier_qualifier a owl:ObjectProperty ;
    rdfs:label "quantifier qualifier" ;
    rdfs:range biolink:OntologyClass ;
    rdfs:subPropertyOf biolink:association_slot ;
    skos:definition "A measurable quantity for the object of the association" ;
    skos:inScheme biolink: ;
    skos:narrowMatch <http://identifiers.org/umls/measures>,
        LOINC:analyzes,
        LOINC:measured_by,
        LOINC:property_of,
        SEMMEDDB:MEASURES .

biolink:related_to a owl:ObjectProperty,
        owl:SymmetricProperty ;
    rdfs:label "related to" ;
    rdfs:domain biolink:NamedThing ;
    rdfs:range biolink:NamedThing ;
    skos:broadMatch owl:topObjectProperty ;
    skos:definition "A relationship that is asserted between two named things" ;
    skos:exactMatch <http://identifiers.org/umls/related_to> ;
    skos:inScheme biolink: ;
    skos:narrowMatch MESH:RO,
        MESH:has_mapping_qualifier,
        MESH:mapped_to,
        <http://identifiers.org/hmdb/disease>,
        <http://identifiers.org/hmdb/has_protein_association>,
        <http://identifiers.org/umls/RO>,
        <http://identifiers.org/umls/RQ>,
        <http://identifiers.org/umls/class_code_classified_by>,
        <http://identifiers.org/umls/exhibited_by>,
        <http://identifiers.org/umls/has_context_binding>,
        <http://identifiers.org/umls/has_form>,
        <http://identifiers.org/umls/has_mapping_qualifier>,
        <http://identifiers.org/umls/larger_than>,
        <http://identifiers.org/umls/mapped_to>,
        <http://identifiers.org/umls/owning_section_of>,
        LOINC:has_answer,
        LOINC:has_challenge,
        LOINC:has_evaluation,
        LOINC:mapped_to,
        LOINC:mth_has_expanded_form,
        HCPCS:mapped_to,
        RXNORM:has_form,
        RXNORM:reformulated_to,
        <http://purl.obolibrary.org/obo/BFO_0000054>,
        <http://purl.obolibrary.org/obo/BTO_related_to>,
        <http://purl.obolibrary.org/obo/CHEBI_is_conjugate_acid_of>,
        <http://purl.obolibrary.org/obo/CHEBI_is_conjugate_base_of>,
        FMA:connected_to,
        FMA:continuous_with,
        FMA:homonym_of,
        FMA:related_developmental_entity_of,
        GOREL:0002005,
        GOREL:0012006,
        IAO:0000136,
        <http://purl.obolibrary.org/obo/MONDO_disease_shares_features_of>,
        <http://purl.obolibrary.org/obo/NCIT_disease_may_have_associated_disease>,
        <http://purl.obolibrary.org/obo/NCIT_human_disease_maps_to_eo_disease>,
        <http://purl.obolibrary.org/obo/NCIT_is_abnormal_cell_of_disease>,
        <http://purl.obolibrary.org/obo/NCIT_is_related_to_endogenous_product>,
        <http://purl.obolibrary.org/obo/PATO_reciprocal_of>,
        RO:0000052,
        RO:0000053,
        RO:0002001,
        RO:0002002,
        RO:0002003,
        RO:0002008,
        RO:0002084,
        RO:0002092,
        RO:0002093,
        RO:0002134,
        RO:0002150,
        RO:0002159,
        RO:0002176,
        RO:0002177,
        RO:0002178,
        RO:0002179,
        RO:0002314,
        RO:0002322,
        RO:0002328,
        RO:0002332,
        RO:0002338,
        RO:0002339,
        RO:0002341,
        RO:0002342,
        RO:0002344,
        RO:0002348,
        RO:0002349,
        RO:0002356,
        RO:0002371,
        RO:0002372,
        RO:0002373,
        RO:0002374,
        RO:0002385,
        RO:0002387,
        RO:0002451,
        RO:0002494,
        RO:0002495,
        RO:0002568,
        RO:0002573,
        RO:0004026,
        RO:0004027,
        RO:0009001,
        RO:0009004,
        <http://purl.obolibrary.org/obo/SNOMED_has_associated_morphology>,
        <http://purl.obolibrary.org/obo/SNOMED_has_associated_procedure>,
        <http://purl.obolibrary.org/obo/SNOMED_has_direct_morphology>,
        <http://purl.obolibrary.org/obo/SNOMED_has_disposition>,
        <http://purl.obolibrary.org/obo/SNOMED_has_indirect_morphology>,
        <http://purl.obolibrary.org/obo/SNOMED_has_modification>,
        <http://purl.obolibrary.org/obo/SNOMED_has_procedure_morphology>,
        <http://purl.obolibrary.org/obo/SNOMED_has_specimen_source_morphology>,
        <http://purl.obolibrary.org/obo/SNOMED_inheres_in>,
        <http://purl.obolibrary.org/obo/SNOMED_is_interpreted_by>,
        <http://purl.obolibrary.org/obo/SNOMED_relative_to_part_of>,
        <http://purl.obolibrary.org/obo/UBERON_synapsed_by>,
        UBERON_NONAMESPACE:connected_to,
        UBERON_NONAMESPACE:innervated_by,
        NBO-PROPERTY:is_about,
        UBERON_CORE:protects,
        EFO:0006351,
        SEMMEDDB:ADMINISTERED_TO,
        SEMMEDDB:ASSOCIATED_WITH,
        SEMMEDDB:compared_with,
        SEMMEDDB:higher_than,
        SEMMEDDB:lower_than,
        CPT:has_add_on_code,
        CPT:mapped_to ;
    biolink:canonical_predicate true .

biolink:sex_qualifier a owl:ObjectProperty ;
    rdfs:label "sex qualifier" ;
    rdfs:range biolink:BiologicalSex ;
    rdfs:subPropertyOf biolink:qualifier ;
    skos:definition "a qualifier used in a phenotypic association to state whether the association is specific to a particular sex." ;
    skos:inScheme biolink: .

biolink:stage_qualifier a owl:ObjectProperty ;
    rdfs:label "stage qualifier" ;
    rdfs:range biolink:LifeStage ;
    rdfs:subPropertyOf biolink:statement_qualifier ;
    skos:definition "stage during which gene or protein expression of takes place." ;
    skos:inScheme biolink: .

biolink:statement_qualifier a owl:DatatypeProperty ;
    rdfs:label "statement qualifier" ;
    rdfs:subPropertyOf biolink:qualifier ;
    skos:definition "A property that qualifies the entirety of the statement made in an association.  It applies to both a fully qualified subject and a fully qualified object as well as the predicate and qualified predicate in an association." ;
    skos:inScheme biolink: .

biolink:study_metadata a owl:DatatypeProperty ;
    rdfs:label "study metadata" ;
    rdfs:subPropertyOf biolink:node_property ;
    skos:definition "Information describing how a study was designed and carried out. In practice, data creators should use one of the more specific subtypes of this property." ;
    skos:inScheme biolink: ;
    skos:note "This is an abstract slot that groups a set of concrete slots that describe a Study itself. Because each of these properties describes a single study, they are node properties of the Study class rather than association slots. An Association links to the studies that supported it via 'has supporting studies', and the metadata for each of those studies is read off the Study node." .

biolink:subject_of_treatment_application_or_study_for_treatment_by a owl:ObjectProperty ;
    rdfs:label "subject of treatment application or study for treatment by" ;
    rdfs:domain biolink:DiseaseOrPhenotypicFeature ;
    rdfs:range biolink:ChemicalOrDrugOrTreatment ;
    rdfs:subPropertyOf biolink:related_to_at_instance_level ;
    owl:inverseOf biolink:treats_or_applied_or_studied_to_treat ;
    skos:inScheme biolink: .

biolink:supporting_study_metadata a owl:DatatypeProperty ;
    rdfs:label "supporting study metadata" ;
    rdfs:subPropertyOf biolink:association_slot ;
    skos:definition "Information about a study used to generate information used as evidence to support the knowledge expressed in an Association. In practice, data creators should use one of the more specific subtypes of this property." ;
    skos:inScheme biolink: .

<https://w3id.org/biolink/vocab/CausalMechanismQualifierEnum#activation> a owl:Class ;
    rdfs:label "activation" ;
    rdfs:subClassOf biolink:CausalMechanismQualifierEnum,
        <https://w3id.org/biolink/vocab/CausalMechanismQualifierEnum#positive_modulation> ;
    skos:closeMatch DGIdb:activator,
        CHEMBL.MECHANISM:activator ;
    skos:definition "A positive modulation mechanism in which the effector binds to and positively affects the normal functioning of its target." .

biolink:ChemicalMixture a owl:Class ;
    rdfs:label "chemical mixture" ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:highest_FDA_approval_status ],
        [ a owl:Restriction ;
            owl:allValuesFrom biolink:ApprovalStatusEnum ;
            owl:onProperty biolink:highest_FDA_approval_status ],
        [ a owl:Restriction ;
            owl:allValuesFrom xsd:string ;
            owl:onProperty biolink:is_supplement ],
        [ a owl:Restriction ;
            owl:minCardinality 0 ;
            owl:onProperty biolink:drug_regulatory_status_world_wide ],
        [ a owl:Restriction ;
            owl:minCardinality 0 ;
            owl:onProperty biolink:highest_FDA_approval_status ],
        [ a owl:Restriction ;
            owl:onProperty linkml:mixins ;
            owl:someValuesFrom biolink:OntologyClass ],
        [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:drug_regulatory_status_world_wide ],
        [ a owl:Restriction ;
            owl:minCardinality 0 ;
            owl:onProperty biolink:is_supplement ],
        [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:is_supplement ],
        [ a owl:Restriction ;
            owl:allValuesFrom biolink:ApprovalStatusEnum ;
            owl:onProperty biolink:drug_regulatory_status_world_wide ],
        biolink:ChemicalEntity ;
    skos:closeMatch dcid:ChemicalCompound ;
    skos:definition "A chemical mixture is a chemical entity composed of two or more molecular entities." ;
    skos:inScheme biolink: ;
    skos:narrowMatch <http://purl.obolibrary.org/obo/NCIT_C20401>,
        SNOMEDCT:49616005 .

biolink:DatasetVersion a owl:Class ;
    rdfs:label "dataset version" ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:minCardinality 0 ;
            owl:onProperty biolink:has_dataset ],
        [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:ingest_date ],
        [ a owl:Restriction ;
            owl:allValuesFrom biolink:Dataset ;
            owl:onProperty biolink:has_dataset ],
        [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:has_dataset ],
        [ a owl:Restriction ;
            owl:allValuesFrom xsd:string ;
            owl:onProperty biolink:ingest_date ],
        [ a owl:Restriction ;
            owl:minCardinality 0 ;
            owl:onProperty biolink:has_distribution ],
        [ a owl:Restriction ;
            owl:allValuesFrom biolink:DatasetDistribution ;
            owl:onProperty biolink:has_distribution ],
        [ a owl:Restriction ;
            owl:minCardinality 0 ;
            owl:onProperty biolink:ingest_date ],
        [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:has_distribution ],
        biolink:InformationContentEntity ;
    skos:definition "an item that holds version level information about a dataset." ;
    skos:inScheme biolink: .

biolink:GeneProductMixin a owl:Class ;
    rdfs:label "gene product mixin" ;
    rdfs:subClassOf biolink:GeneOrGeneProduct ;
    skos:definition "The functional molecular product of a single gene locus. Gene products are either proteins or functional RNA molecules." ;
    skos:exactMatch <http://purl.obolibrary.org/obo/GENO_0000907>,
        <http://purl.obolibrary.org/obo/NCIT_C26548>,
        WIKIDATA:Q424689 ;
    skos:inScheme biolink: .

biolink:GeneToEntityAssociationMixin a owl:Class ;
    rdfs:label "gene to entity association mixin" ;
    rdfs:subClassOf <https://w3id.org/linkml/ClassDefinition#Mixin> ;
    skos:inScheme biolink: .

biolink:PhysicalEssenceOrOccurrent a owl:Class ;
    rdfs:label "physical essence or occurrent" ;
    rdfs:subClassOf <https://w3id.org/linkml/ClassDefinition#Mixin> ;
    skos:definition "Either a physical or processual entity." ;
    skos:inScheme biolink: .

biolink:StatisticalSignificanceQualifierEnum a owl:Class ;
    rdfs:label "StatisticalSignificanceQualifierEnum" ;
    rdfs:subClassOf linkml:EnumDefinition ;
    owl:unionOf ( <https://w3id.org/biolink/vocab/StatisticalSignificanceQualifierEnum#very_strongly_significant> <https://w3id.org/biolink/vocab/StatisticalSignificanceQualifierEnum#strongly_significant> <https://w3id.org/biolink/vocab/StatisticalSignificanceQualifierEnum#significant> <https://w3id.org/biolink/vocab/StatisticalSignificanceQualifierEnum#suggestive> <https://w3id.org/biolink/vocab/StatisticalSignificanceQualifierEnum#not_significant> ) ;
    skos:definition "An enumeration used as a qualifier to categorize the statistical significance of an association's supporting evidence into coarse bands (e.g., very strongly significant, strongly significant, significant, suggestive, not significant), conventionally anchored to alpha = 0.05. The underlying numeric value lives in the 'p value' and 'adjusted p value' slots, which remain authoritative." ;
    skos:inScheme biolink: ;
    linkml:permissible_values <https://w3id.org/biolink/vocab/StatisticalSignificanceQualifierEnum#not_significant>,
        <https://w3id.org/biolink/vocab/StatisticalSignificanceQualifierEnum#significant>,
        <https://w3id.org/biolink/vocab/StatisticalSignificanceQualifierEnum#strongly_significant>,
        <https://w3id.org/biolink/vocab/StatisticalSignificanceQualifierEnum#suggestive>,
        <https://w3id.org/biolink/vocab/StatisticalSignificanceQualifierEnum#very_strongly_significant> .

biolink:ThingWithTaxon a owl:Class ;
    rdfs:label "thing with taxon" ;
    rdfs:subClassOf <https://w3id.org/linkml/ClassDefinition#Mixin> ;
    skos:definition "A mixin that can be used on any entity that can be taxonomically classified. This includes individual organisms; genes, their products and other molecular entities; body parts; biological processes" ;
    skos:inScheme biolink: .

biolink:affects a owl:DatatypeProperty ;
    rdfs:label "affects" ;
    rdfs:subPropertyOf biolink:related_to_at_instance_level ;
    skos:definition "Describes an entity that has an effect on the state or quality of another existing entity." ;
    skos:editorialNote "A note on 'affects' vs 'interacts with': These are related but separate relationships. An interaction may or may not involve one interactor exerting an effect on the other. Effects may be mediated by an interaction or may arise without any direct interaction, through a chain of intermediary events. An affects relationship asserts that one entity directly or indirectly exerts a meaningful influence on the activity, state, abundance, function, or properties of another entity. Unlike an interaction, an effect is directional: the subject changes, modulates, perturbs, regulates, or otherwise influences the object, even if no direct physical interaction occurs. Use interacts_with only when the relationship describes an interaction or association without asserting that one entity exerts an effect on the other.",
        "Use of the 'affects' predicate implies that the affected entity already exists, unlike predicates such as 'affects likelihood of' and 'prevents' where the effect concerns whether or when something may or may not come into existence." ;
    skos:exactMatch SEMMEDDB:AFFECTS,
        DGIdb:affects ;
    skos:inScheme biolink: ;
    skos:narrowMatch CTD:inferred,
        CTD:prediction_hypothesis,
        GOREL:0001006,
        <http://purl.obolibrary.org/obo/NCIT_R100>,
        <http://purl.obolibrary.org/obo/NCIT_R101>,
        <http://purl.obolibrary.org/obo/NCIT_R102>,
        <http://purl.obolibrary.org/obo/NCIT_R113>,
        <http://purl.obolibrary.org/obo/NCIT_R124>,
        <http://purl.obolibrary.org/obo/NCIT_R133>,
        <http://purl.obolibrary.org/obo/NCIT_R146>,
        <http://purl.obolibrary.org/obo/NCIT_R150>,
        <http://purl.obolibrary.org/obo/NCIT_R158>,
        <http://purl.obolibrary.org/obo/NCIT_R160>,
        <http://purl.obolibrary.org/obo/NCIT_R173>,
        <http://purl.obolibrary.org/obo/NCIT_R23>,
        <http://purl.obolibrary.org/obo/NCIT_R25>,
        <http://purl.obolibrary.org/obo/NCIT_R30>,
        <http://purl.obolibrary.org/obo/NCIT_R72>,
        <http://purl.obolibrary.org/obo/NCIT_gene_mapped_to_disease>,
        RO:0002263,
        RO:0002264,
        RO:0002343,
        RO:0002355,
        RO:0002591,
        RO:0002592,
        RO:0012003,
        <http://purl.obolibrary.org/obo/SNOMED_has_pathological_process>,
        <http://purl.obolibrary.org/obo/UPHENO_0000001>,
        UBERGRAPH:is_decrease_of,
        UBERGRAPH:is_increase_of ;
    skos:relatedMatch <http://identifiers.org/drugbank/pathway> ;
    biolink:canonical_predicate true .

biolink:associated_with a owl:ObjectProperty,
        owl:SymmetricProperty ;
    rdfs:label "associated with" ;
    rdfs:domain biolink:NamedThing ;
    rdfs:range biolink:NamedThing ;
    rdfs:subPropertyOf biolink:related_to_at_instance_level ;
    skos:definition "Indicates a non-causal association between two entities. Such associations are most commonly established through statistical analysis demonstrating that observations of the entities are not statistically independent, but may also be supported by other forms of evidence that establish a meaningful association. When representing a statistical association, the subject and object may correspond directly to the variables analyzed, or to the biological or clinical entities represented/described by those variables (e.g., diseases, genes, chemical entities, biological processes, or phenotypes).  The 'association basis qualifier' may be used to constrain the scope of this predicate within a statement if no more specific child predicate provides a more precise semantic context for the association." ;
    skos:inScheme biolink: ;
    skos:narrowMatch RO:0004029,
        SNOMEDCT:47429007 ;
    biolink:canonical_predicate true .

biolink:has_count a owl:DatatypeProperty ;
    rdfs:label "has count" ;
    rdfs:range xsd:integer ;
    rdfs:subPropertyOf biolink:aggregate_statistic ;
    skos:definition "number of things with a particular property" ;
    skos:exactMatch LOINC:has_count ;
    skos:inScheme biolink: .

biolink:has_output a owl:ObjectProperty ;
    rdfs:label "has output" ;
    rdfs:domain biolink:BiologicalProcessOrActivity ;
    rdfs:range biolink:NamedThing ;
    rdfs:subPropertyOf biolink:has_participant ;
    skos:definition "holds between a process and a continuant, where the continuant is an output of the process" ;
    skos:exactMatch RO:0002234 ;
    skos:inScheme biolink: ;
    skos:narrowMatch <http://purl.obolibrary.org/obo/NCIT_R31>,
        <http://purl.obolibrary.org/obo/OBI_0000299>,
        RO:0002296,
        RO:0002297,
        RO:0002298,
        RO:0002299,
        RO:0002588,
        RO:0004008,
        PathWhiz:has_right_element ;
    biolink:canonical_predicate true ;
    biolink:opposite_of "has input" .

biolink:has_participant a owl:ObjectProperty ;
    rdfs:label "has participant" ;
    rdfs:domain biolink:BiologicalProcessOrActivity ;
    rdfs:range biolink:Occurrent ;
    rdfs:subPropertyOf biolink:related_to_at_instance_level ;
    skos:closeMatch WIKIDATA_PROPERTY:P2283 ;
    skos:definition "holds between a process and a continuant, where the continuant is somehow involved in the process" ;
    skos:exactMatch RO:0000057,
        RO:has_participant ;
    skos:inScheme biolink: ;
    skos:narrowMatch LOINC:has_subject,
        <http://purl.obolibrary.org/obo/BFO_0000167>,
        <http://purl.obolibrary.org/obo/NCIT_process_involves_gene>,
        <http://purl.obolibrary.org/obo/OBI_0000293>,
        RO:0002565,
        RO:0004007,
        RO:0004020,
        RO:0004021,
        <http://purl.obolibrary.org/obo/SNOMED_has_indirect_device>,
        <http://purl.obolibrary.org/obo/SNOMED_has_procedure_device>,
        <http://purl.obolibrary.org/obo/SNOMED_has_recipient_category>,
        NBO-PROPERTY:has_participant,
        PathWhiz:has_bound,
        PathWhiz:has_compound,
        PathWhiz:has_element_collection,
        PathWhiz:has_enzyme,
        PathWhiz:has_nucleic_acid,
        PathWhiz:has_protein,
        PathWhiz:has_reaction ;
    biolink:canonical_predicate true .

biolink:has_sequence_variant a owl:ObjectProperty ;
    rdfs:label "has sequence variant" ;
    rdfs:domain biolink:GenomicEntity ;
    rdfs:range biolink:SequenceVariant ;
    rdfs:subPropertyOf biolink:related_to_at_instance_level ;
    owl:inverseOf biolink:is_sequence_variant_of ;
    skos:inScheme biolink: .

biolink:treats_or_applied_or_studied_to_treat a owl:ObjectProperty ;
    rdfs:label "treats or applied or studied to treat" ;
    rdfs:domain biolink:ChemicalOrDrugOrTreatment ;
    rdfs:range biolink:DiseaseOrPhenotypicFeature ;
    rdfs:subPropertyOf biolink:related_to_at_instance_level ;
    skos:definition "Holds between an substance, procedure, or activity and a medical condition (disease or phenotypic feature), and states that the substance, procedure, or activity is able to treat the condition, has been observed to be taken/prescribed in practice with the intent of treating the condition, or has been interrogated in a scientific study that hypothesized an ability to treat the condition (in humans or other biological systems/organisms)." ;
    skos:editorialNote "This predicate is helpful both as a grouping predicate to aid in searching for broader senses of treating a condition, and as a catch-all for representing sources that are not clear about the sense of treats that is being reported. For example, text-mined statements concerning treatments for disease are based on sentences that can report treatment in any of these different senses and thus require a broader predicate such as this to safely report statement semantics." ;
    skos:exactMatch SEMMEDDB:TREATS ;
    skos:inScheme biolink: ;
    biolink:canonical_predicate true .

biolink:CellularOrganism a owl:Class ;
    rdfs:label "cellular organism" ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:onProperty linkml:mixins ;
            owl:someValuesFrom biolink:SubjectOfInvestigation ],
        biolink:OrganismalEntity ;
    skos:definition "An organism that contains one or more cells belonging to the cellular lineages of life (Archaea, Bacteria, or Eukaryota), whose body consists of one or more cells. Distinguished from acellular biological entities such as viruses and viroids." ;
    skos:exactMatch <http://purl.obolibrary.org/obo/NCBITaxon_131567> ;
    skos:inScheme biolink: ;
    skos:note "see: https://github.com/OBOFoundry/COB/pull/211" .

biolink:ClinicalApprovalStatusEnum a owl:Class ;
    rdfs:label "ClinicalApprovalStatusEnum" ;
    rdfs:subClassOf linkml:EnumDefinition ;
    owl:unionOf ( <https://w3id.org/biolink/vocab/ClinicalApprovalStatusEnum#approved_for_condition> <https://w3id.org/biolink/vocab/ClinicalApprovalStatusEnum#fda_approved_for_condition> <https://w3id.org/biolink/vocab/ClinicalApprovalStatusEnum#not_approved_for_condition> <https://w3id.org/biolink/vocab/ClinicalApprovalStatusEnum#post_approval_withdrawal> <https://w3id.org/biolink/vocab/ClinicalApprovalStatusEnum#off_label_use> <https://w3id.org/biolink/vocab/ClinicalApprovalStatusEnum#not_provided> ) ;
    skos:definition "An enumeration describing whether a chemical or therapy is approved for use in treating a specific condition (e.g., FDA-approved for a condition, not approved, off-label use, or withdrawn following approval)." ;
    skos:inScheme biolink: ;
    linkml:permissible_values <https://w3id.org/biolink/vocab/ClinicalApprovalStatusEnum#approved_for_condition>,
        <https://w3id.org/biolink/vocab/ClinicalApprovalStatusEnum#fda_approved_for_condition>,
        <https://w3id.org/biolink/vocab/ClinicalApprovalStatusEnum#not_approved_for_condition>,
        <https://w3id.org/biolink/vocab/ClinicalApprovalStatusEnum#not_provided>,
        <https://w3id.org/biolink/vocab/ClinicalApprovalStatusEnum#off_label_use>,
        <https://w3id.org/biolink/vocab/ClinicalApprovalStatusEnum#post_approval_withdrawal> .

biolink:GeneticInheritance a owl:Class ;
    rdfs:label "genetic inheritance" ;
    rdfs:subClassOf biolink:BiologicalEntity ;
    skos:altLabel "inheritance" ;
    skos:closeMatch STY:T045 ;
    skos:definition "The pattern or 'mode' in which a particular genetic trait or disorder is passed from one generation to the next." ;
    skos:exactMatch <http://purl.obolibrary.org/obo/GENO_0000141>,
        <http://purl.obolibrary.org/obo/HP_0000005>,
        <http://purl.obolibrary.org/obo/NCIT_C45827> ;
    skos:inScheme biolink: .

<https://w3id.org/biolink/vocab/ResearchPhaseEnum#clinical_trial_phase> a owl:Class ;
    rdfs:label "clinical_trial_phase" ;
    rdfs:subClassOf biolink:ResearchPhaseEnum,
        linkml:PermissibleValue ;
    skos:definition "Clinical research involves trials of the drug on people, and it is one of the most involved stages in the drug development and approval process. Clinical trials must answer specific questions and follow a protocol determined by the drug researcher or manufacturer." .

biolink:StrandEnum a owl:Class ;
    rdfs:label "StrandEnum" ;
    rdfs:subClassOf linkml:EnumDefinition ;
    owl:unionOf ( <https://w3id.org/biolink/vocab/StrandEnum#%2B> <https://w3id.org/biolink/vocab/StrandEnum#-> <https://w3id.org/biolink/vocab/StrandEnum#.> <https://w3id.org/biolink/vocab/StrandEnum#%3F> ) ;
    skos:definition "strand" ;
    skos:inScheme biolink: ;
    linkml:permissible_values <https://w3id.org/biolink/vocab/StrandEnum#%2B>,
        <https://w3id.org/biolink/vocab/StrandEnum#%3F>,
        <https://w3id.org/biolink/vocab/StrandEnum#->,
        <https://w3id.org/biolink/vocab/StrandEnum#.> .

biolink:Study a owl:Class ;
    rdfs:label "study" ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:study_method_description ],
        [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:study_context ],
        [ a owl:Restriction ;
            owl:allValuesFrom xsd:string ;
            owl:onProperty biolink:study_date_range ],
        [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:study_date_range ],
        [ a owl:Restriction ;
            owl:minCardinality 0 ;
            owl:onProperty biolink:study_cohort ],
        [ a owl:Restriction ;
            owl:minCardinality 0 ;
            owl:onProperty biolink:study_method_types ],
        [ a owl:Restriction ;
            owl:minCardinality 0 ;
            owl:onProperty biolink:has_study_results ],
        [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:study_cohort ],
        [ a owl:Restriction ;
            owl:minCardinality 0 ;
            owl:onProperty biolink:study_context ],
        [ a owl:Restriction ;
            owl:allValuesFrom biolink:StudyResult ;
            owl:onProperty biolink:has_study_results ],
        [ a owl:Restriction ;
            owl:allValuesFrom xsd:string ;
            owl:onProperty biolink:study_cohort ],
        [ a owl:Restriction ;
            owl:minCardinality 0 ;
            owl:onProperty biolink:study_date_range ],
        [ a owl:Restriction ;
            owl:allValuesFrom xsd:anyURI ;
            owl:onProperty biolink:study_method_description ],
        [ a owl:Restriction ;
            owl:allValuesFrom xsd:anyURI ;
            owl:onProperty biolink:study_method_types ],
        [ a owl:Restriction ;
            owl:allValuesFrom xsd:string ;
            owl:onProperty biolink:study_context ],
        [ a owl:Restriction ;
            owl:minCardinality 0 ;
            owl:onProperty biolink:study_method_description ],
        [ a owl:Restriction ;
            owl:allValuesFrom xsd:integer ;
            owl:onProperty biolink:study_size ],
        [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:study_size ],
        [ a owl:Restriction ;
            owl:minCardinality 0 ;
            owl:onProperty biolink:study_size ],
        biolink:Activity ;
    skos:closeMatch <http://purl.obolibrary.org/obo/SEPIO_0000004>,
        SIO:001066 ;
    skos:definition "a detailed investigation and/or analysis" ;
    skos:exactMatch <http://purl.obolibrary.org/obo/NCIT_C63536> ;
    skos:inScheme biolink: ;
    skos:narrowMatch SIO:000994 .

biolink:TreatmentOutcomeEnum a owl:Class ;
    rdfs:label "TreatmentOutcomeEnum" ;
    rdfs:subClassOf linkml:EnumDefinition ;
    owl:unionOf ( <https://w3id.org/biolink/vocab/TreatmentOutcomeEnum#fully_recovered> <https://w3id.org/biolink/vocab/TreatmentOutcomeEnum#improved> <https://w3id.org/biolink/vocab/TreatmentOutcomeEnum#unchanged> <https://w3id.org/biolink/vocab/TreatmentOutcomeEnum#deteriorated> <https://w3id.org/biolink/vocab/TreatmentOutcomeEnum#died> <https://w3id.org/biolink/vocab/TreatmentOutcomeEnum#unknown> ) ;
    skos:definition "The outcome of treating a disease or phenotypic feature with a chemical entity." ;
    skos:inScheme biolink: ;
    linkml:permissible_values <https://w3id.org/biolink/vocab/TreatmentOutcomeEnum#deteriorated>,
        <https://w3id.org/biolink/vocab/TreatmentOutcomeEnum#died>,
        <https://w3id.org/biolink/vocab/TreatmentOutcomeEnum#fully_recovered>,
        <https://w3id.org/biolink/vocab/TreatmentOutcomeEnum#improved>,
        <https://w3id.org/biolink/vocab/TreatmentOutcomeEnum#unchanged>,
        <https://w3id.org/biolink/vocab/TreatmentOutcomeEnum#unknown> .

biolink:has_attribute a owl:ObjectProperty ;
    rdfs:label "has attribute" ;
    rdfs:domain biolink:Entity ;
    rdfs:range biolink:Attribute ;
    skos:closeMatch <http://purl.obolibrary.org/obo/OBI_0001927> ;
    skos:definition "connects any entity to an attribute" ;
    skos:exactMatch SIO:000008 ;
    skos:inScheme biolink: ;
    skos:narrowMatch <http://identifiers.org/drugbank/category>,
        <http://identifiers.org/umls/has_structural_class>,
        <http://identifiers.org/umls/has_supported_concept_property>,
        <http://identifiers.org/umls/has_supported_concept_relationship>,
        <http://identifiers.org/umls/may_be_qualified_by>,
        LOINC:has_action_guidance,
        LOINC:has_adjustment,
        LOINC:has_aggregation_view,
        LOINC:has_approach_guidance,
        LOINC:has_divisor,
        LOINC:has_exam,
        LOINC:has_method,
        LOINC:has_modality_subtype,
        LOINC:has_object_guidance,
        LOINC:has_scale,
        LOINC:has_suffix,
        LOINC:has_time_aspect,
        LOINC:has_time_modifier,
        LOINC:has_timing_of,
        INO:0000154,
        <http://purl.obolibrary.org/obo/NCIT_R88>,
        <http://purl.obolibrary.org/obo/NCIT_eo_disease_has_property_or_attribute>,
        <http://purl.obolibrary.org/obo/NCIT_has_data_element>,
        <http://purl.obolibrary.org/obo/NCIT_has_pharmaceutical_administration_method>,
        <http://purl.obolibrary.org/obo/NCIT_has_pharmaceutical_basic_dose_form>,
        <http://purl.obolibrary.org/obo/NCIT_has_pharmaceutical_intended_site>,
        <http://purl.obolibrary.org/obo/NCIT_has_pharmaceutical_release_characteristics>,
        <http://purl.obolibrary.org/obo/NCIT_has_pharmaceutical_state_of_matter>,
        <http://purl.obolibrary.org/obo/NCIT_has_pharmaceutical_transformation>,
        <http://purl.obolibrary.org/obo/NCIT_is_qualified_by>,
        <http://purl.obolibrary.org/obo/NCIT_qualifier_applies_to>,
        <http://purl.obolibrary.org/obo/NCIT_role_has_domain>,
        <http://purl.obolibrary.org/obo/NCIT_role_has_range>,
        RO:0000053,
        RO:0000086,
        RO:0000087,
        <http://purl.obolibrary.org/obo/SNOMED_has_access>,
        <http://purl.obolibrary.org/obo/SNOMED_has_clinical_course>,
        <http://purl.obolibrary.org/obo/SNOMED_has_count_of_base_of_active_ingredient>,
        <http://purl.obolibrary.org/obo/SNOMED_has_dose_form_administration_method>,
        <http://purl.obolibrary.org/obo/SNOMED_has_dose_form_release_characteristic>,
        <http://purl.obolibrary.org/obo/SNOMED_has_dose_form_transformation>,
        <http://purl.obolibrary.org/obo/SNOMED_has_finding_context>,
        <http://purl.obolibrary.org/obo/SNOMED_has_finding_informer>,
        <http://purl.obolibrary.org/obo/SNOMED_has_inherent_attribute>,
        <http://purl.obolibrary.org/obo/SNOMED_has_intent>,
        <http://purl.obolibrary.org/obo/SNOMED_has_interpretation>,
        <http://purl.obolibrary.org/obo/SNOMED_has_laterality>,
        <http://purl.obolibrary.org/obo/SNOMED_has_measurement_method>,
        <http://purl.obolibrary.org/obo/SNOMED_has_method>,
        <http://purl.obolibrary.org/obo/SNOMED_has_priority>,
        <http://purl.obolibrary.org/obo/SNOMED_has_procedure_context>,
        <http://purl.obolibrary.org/obo/SNOMED_has_process_duration>,
        <http://purl.obolibrary.org/obo/SNOMED_has_property>,
        <http://purl.obolibrary.org/obo/SNOMED_has_revision_status>,
        <http://purl.obolibrary.org/obo/SNOMED_has_scale_type>,
        <http://purl.obolibrary.org/obo/SNOMED_has_severity>,
        <http://purl.obolibrary.org/obo/SNOMED_has_specimen>,
        <http://purl.obolibrary.org/obo/SNOMED_has_state_of_matter>,
        <http://purl.obolibrary.org/obo/SNOMED_has_subject_relationship_context>,
        <http://purl.obolibrary.org/obo/SNOMED_has_surgical_approach>,
        <http://purl.obolibrary.org/obo/SNOMED_has_technique>,
        <http://purl.obolibrary.org/obo/SNOMED_has_temporal_context>,
        <http://purl.obolibrary.org/obo/SNOMED_has_time_aspect>,
        <http://purl.obolibrary.org/obo/SNOMED_has_units>,
        OBAN:association_has_object_property,
        OBAN:association_has_subject_property,
        HANCESTRO:0301,
        HANCESTRO:0308,
        EFO:is_executed_in,
        ORDO:Orphanet_C016,
        ORDO:Orphanet_C017,
        CPT:has_possibly_included_panel_element .

biolink:has_input a owl:ObjectProperty ;
    rdfs:label "has input" ;
    rdfs:domain biolink:BiologicalProcessOrActivity ;
    rdfs:range biolink:NamedThing ;
    rdfs:subPropertyOf biolink:has_participant ;
    skos:definition "holds between a process and a continuant, where the continuant is an input into the process" ;
    skos:exactMatch RO:0002233,
        SEMMEDDB:USES ;
    skos:inScheme biolink: ;
    skos:narrowMatch LOINC:has_fragments_for_synonyms,
        LOINC:has_system,
        RO:0002590,
        RO:0004009,
        <http://purl.obolibrary.org/obo/SNOMED_has_finding_method>,
        <http://purl.obolibrary.org/obo/SNOMED_has_precondition>,
        <http://purl.obolibrary.org/obo/SNOMED_has_specimen_source_identity>,
        <http://purl.obolibrary.org/obo/SNOMED_has_specimen_substance>,
        <http://purl.obolibrary.org/obo/SNOMED_uses_access_device>,
        <http://purl.obolibrary.org/obo/SNOMED_uses_device>,
        <http://purl.obolibrary.org/obo/SNOMED_uses_energy>,
        <http://purl.obolibrary.org/obo/SNOMED_uses_substance>,
        PathWhiz:has_left_element ;
    biolink:canonical_predicate true ;
    biolink:opposite_of "has output" .

biolink:is_sequence_variant_of a owl:ObjectProperty ;
    rdfs:label "is sequence variant of" ;
    rdfs:domain biolink:SequenceVariant ;
    rdfs:range biolink:GenomicEntity ;
    rdfs:subPropertyOf biolink:related_to_at_instance_level ;
    skos:altLabel "allelic variant of",
        "gene product sequence variation encoded by gene mutant",
        "gene product variant of gene product" ;
    skos:definition "holds between a sequence variant and a nucleic acid entity" ;
    skos:inScheme biolink: ;
    skos:narrowMatch WIKIDATA:P3433 ;
    biolink:canonical_predicate true .

biolink:synonym a owl:DatatypeProperty ;
    rdfs:label "synonym" ;
    rdfs:domain biolink:NamedThing ;
    rdfs:range xsd:string ;
    rdfs:subPropertyOf biolink:node_property ;
    skos:altLabel "alias" ;
    skos:definition "Alternate human-readable names for a thing" ;
    skos:inScheme biolink: ;
    skos:narrowMatch RXNORM:has_tradename,
        IAO:0000136,
        HANCESTRO:0330,
        skos:altLabel,
        gff3:Alias,
        gpi:DB_Object_Synonyms,
        AGRKB:synonyms .

biolink:BiologicalSex a owl:Class ;
    rdfs:label "biological sex" ;
    rdfs:subClassOf biolink:Attribute ;
    skos:definition "An organismal quality inhering in a bearer by virtue of the bearer's ability to undergo sexual reproduction in order to differentiate the individuals or types involved." ;
    skos:exactMatch <http://purl.obolibrary.org/obo/PATO_0000047> ;
    skos:inScheme biolink: .

biolink:Dataset a owl:Class ;
    rdfs:label "dataset" ;
    rdfs:subClassOf biolink:InformationContentEntity ;
    skos:definition "an item that refers to a collection of data from a data source." ;
    skos:exactMatch IAO:0000100,
        dcmitype:Dataset,
        schema1:dataset,
        dcid:Dataset ;
    skos:inScheme biolink: .

biolink:Drug a owl:Class ;
    rdfs:label "drug" ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:onProperty linkml:mixins ;
            owl:someValuesFrom biolink:ChemicalOrDrugOrTreatment ],
        [ a owl:Restriction ;
            owl:onProperty linkml:mixins ;
            owl:someValuesFrom biolink:OntologyClass ],
        biolink:MolecularMixture ;
    skos:broadMatch STY:T121 ;
    skos:definition "A substance intended for use in the diagnosis, cure, mitigation, treatment, or prevention of disease" ;
    skos:exactMatch STY:T200,
        <http://purl.obolibrary.org/obo/CHEBI_23888>,
        dcid:Drug,
        WIKIDATA:Q12140 ;
    skos:inScheme biolink: ;
    skos:narrowMatch STY:T195 ;
    skos:note "The CHEBI ID represents a role rather than a substance" .

biolink:DrugDeliveryEnum a owl:Class ;
    rdfs:label "DrugDeliveryEnum" ;
    rdfs:subClassOf linkml:EnumDefinition ;
    owl:unionOf ( <https://w3id.org/biolink/vocab/DrugDeliveryEnum#inhalation> <https://w3id.org/biolink/vocab/DrugDeliveryEnum#oral> <https://w3id.org/biolink/vocab/DrugDeliveryEnum#absorption_through_the_skin> <https://w3id.org/biolink/vocab/DrugDeliveryEnum#injection> <https://w3id.org/biolink/vocab/DrugDeliveryEnum#intravenous_injection> <https://w3id.org/biolink/vocab/DrugDeliveryEnum#subcutaneous_injection> <https://w3id.org/biolink/vocab/DrugDeliveryEnum#intramuscular_injection> ) ;
    skos:definition "An enumeration of routes by which a drug is administered or delivered to a patient, including inhalation, oral, transdermal absorption, and various forms of injection (intravenous, subcutaneous, intramuscular)." ;
    skos:inScheme biolink: ;
    linkml:permissible_values <https://w3id.org/biolink/vocab/DrugDeliveryEnum#absorption_through_the_skin>,
        <https://w3id.org/biolink/vocab/DrugDeliveryEnum#inhalation>,
        <https://w3id.org/biolink/vocab/DrugDeliveryEnum#injection>,
        <https://w3id.org/biolink/vocab/DrugDeliveryEnum#intramuscular_injection>,
        <https://w3id.org/biolink/vocab/DrugDeliveryEnum#intravenous_injection>,
        <https://w3id.org/biolink/vocab/DrugDeliveryEnum#oral>,
        <https://w3id.org/biolink/vocab/DrugDeliveryEnum#subcutaneous_injection> .

<https://w3id.org/biolink/vocab/EffectTypeEnum#correlation_coefficient> a owl:Class ;
    rdfs:label "correlation_coefficient" ;
    rdfs:subClassOf biolink:EffectTypeEnum,
        linkml:PermissibleValue ;
    skos:closeMatch <http://purl.obolibrary.org/obo/STATO_0000142> ;
    skos:definition "A normalized measure of association between two variables, ranging from -1 to +1, computed as covariance divided by the product of standard deviations." .

biolink:EntityToDiseaseOrPhenotypicFeatureAssociationMixin a owl:Class ;
    rdfs:label "entity to disease or phenotypic feature association mixin" ;
    rdfs:subClassOf biolink:FrequencyQualifierMixin ;
    skos:definition "A mixin applied to any association whose object (target node) is a disease or a phenotypic feature. Provides the shared qualifier vocabulary for such statements; subtypes narrow the object range to a disease or to a phenotypic feature specifically." ;
    skos:inScheme biolink: .

biolink:KnowledgeLevelEnum a owl:Class ;
    rdfs:label "KnowledgeLevelEnum" ;
    rdfs:subClassOf linkml:EnumDefinition ;
    owl:unionOf ( <https://w3id.org/biolink/vocab/KnowledgeLevelEnum#knowledge_assertion> <https://w3id.org/biolink/vocab/KnowledgeLevelEnum#logical_entailment> <https://w3id.org/biolink/vocab/KnowledgeLevelEnum#prediction> <https://w3id.org/biolink/vocab/KnowledgeLevelEnum#statistical_association> <https://w3id.org/biolink/vocab/KnowledgeLevelEnum#text_co_occurrence> <https://w3id.org/biolink/vocab/KnowledgeLevelEnum#observation> <https://w3id.org/biolink/vocab/KnowledgeLevelEnum#not_provided> ) ;
    skos:definition "An enumeration characterizing the type of knowledge expressed in a statement and the kind of evidence and reasoning that supports it, as defined by the Translator Knowledge Level / Agent Type (KL/AT) standard. Values include knowledge assertion, logical entailment, prediction, statistical association, text co-occurrence, direct observation, and not-provided." ;
    skos:inScheme biolink: ;
    linkml:permissible_values <https://w3id.org/biolink/vocab/KnowledgeLevelEnum#knowledge_assertion>,
        <https://w3id.org/biolink/vocab/KnowledgeLevelEnum#logical_entailment>,
        <https://w3id.org/biolink/vocab/KnowledgeLevelEnum#not_provided>,
        <https://w3id.org/biolink/vocab/KnowledgeLevelEnum#observation>,
        <https://w3id.org/biolink/vocab/KnowledgeLevelEnum#prediction>,
        <https://w3id.org/biolink/vocab/KnowledgeLevelEnum#statistical_association>,
        <https://w3id.org/biolink/vocab/KnowledgeLevelEnum#text_co_occurrence> .

biolink:MacromolecularMachineMixin a owl:Class ;
    rdfs:label "macromolecular machine mixin" ;
    rdfs:subClassOf <https://w3id.org/linkml/ClassDefinition#Mixin> ;
    skos:definition "A union of gene locus, gene product, and macromolecular complex. These are the basic units of function in a cell. They either carry out individual biological activities, or they encode molecules which do this." ;
    skos:inScheme biolink: .

biolink:MolecularActivity a owl:Class ;
    rdfs:label "molecular activity" ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:allValuesFrom biolink:MolecularEntity ;
            owl:onProperty biolink:has_input ],
        [ a owl:Restriction ;
            owl:onProperty linkml:mixins ;
            owl:someValuesFrom biolink:Occurrent ],
        [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:has_input ],
        [ a owl:Restriction ;
            owl:allValuesFrom biolink:MacromolecularMachineMixin ;
            owl:onProperty biolink:enabled_by ],
        [ a owl:Restriction ;
            owl:minCardinality 0 ;
            owl:onProperty biolink:enabled_by ],
        [ a owl:Restriction ;
            owl:onProperty linkml:mixins ;
            owl:someValuesFrom biolink:OntologyClass ],
        [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:has_output ],
        [ a owl:Restriction ;
            owl:minCardinality 0 ;
            owl:onProperty biolink:has_output ],
        [ a owl:Restriction ;
            owl:allValuesFrom biolink:MolecularEntity ;
            owl:onProperty biolink:has_output ],
        [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:enabled_by ],
        [ a owl:Restriction ;
            owl:minCardinality 0 ;
            owl:onProperty biolink:has_input ],
        biolink:BiologicalProcessOrActivity ;
    skos:altLabel "molecular event",
        "molecular function",
        "reaction" ;
    skos:broadMatch STY:T045 ;
    skos:definition "An execution of a molecular function carried out by a gene product or macromolecular complex." ;
    skos:exactMatch STY:T044,
        <http://purl.obolibrary.org/obo/GO_0003674> ;
    skos:inScheme biolink: .

biolink:evidence_count a owl:DatatypeProperty ;
    rdfs:label "evidence count" ;
    rdfs:range xsd:integer ;
    rdfs:subPropertyOf biolink:association_slot ;
    skos:definition "The number of evidence instances that are connected to an association." ;
    skos:inScheme biolink: .

biolink:has_biological_sequence a owl:DatatypeProperty ;
    rdfs:label "has biological sequence" ;
    rdfs:range xsd:string ;
    rdfs:subPropertyOf biolink:node_property ;
    skos:definition "connects a genomic feature to its sequence" ;
    skos:inScheme biolink: .

biolink:object_derivative_qualifier a owl:DatatypeProperty ;
    rdfs:label "object derivative qualifier" ;
    rdfs:subPropertyOf biolink:derivative_qualifier ;
    skos:definition "A qualifier that composes with a core subject/object  concept to describe something that is derived from the core concept.  For example, the qualifier ‘metabolite’ combines with a ‘Chemical X’ core concept to express the composed concept ‘a metabolite of Chemical X’.  This qualifier is for the object of an association (or statement)." ;
    skos:inScheme biolink: .

biolink:onset_qualifier a owl:ObjectProperty ;
    rdfs:label "onset qualifier" ;
    rdfs:range biolink:Onset ;
    rdfs:subPropertyOf biolink:qualifier ;
    skos:definition "a qualifier used in a phenotypic association to state when the phenotype appears is in the subject." ;
    skos:editorialNote "This  is in Biolink to support HP ontology annotations which use \"onset\" (with terms from HP) as an annotation on a disease to phenotypic feature association.  Please only use it for this purpose.  If the intent is to describe the onset of a disease in the context of a treatment, use object_aspect_qualifier and object_direction_qualifier to capture \"delayed onset\" or \"exacerbated onset\" slot." ;
    skos:inScheme biolink: .

biolink:population_context_qualifier a owl:ObjectProperty ;
    rdfs:label "population context qualifier" ;
    rdfs:range biolink:PopulationOfIndividualOrganisms ;
    rdfs:subPropertyOf biolink:qualifier ;
    skos:definition "a biological population (general, study, cohort, etc.) with a specific set of characteristics to constrain an association." ;
    skos:inScheme biolink: .

biolink:related_to_at_concept_level a owl:DatatypeProperty,
        owl:SymmetricProperty ;
    rdfs:label "related to at concept level" ;
    rdfs:subPropertyOf biolink:related_to ;
    skos:definition "Represents a relationship held between terminology components that describe the conceptual model of a domain." ;
    skos:inScheme biolink: ;
    biolink:canonical_predicate true .

biolink:timepoint a owl:DatatypeProperty ;
    rdfs:label "timepoint" ;
    rdfs:range xsd:string ;
    skos:altLabel "duration" ;
    skos:definition "a point in time" ;
    skos:inScheme biolink: .

biolink:type a owl:DatatypeProperty ;
    rdfs:label "type" ;
    rdfs:domain biolink:Entity ;
    skos:definition "An rdf:type property asserting that an entity is an instance of a particular class. In Biolink the value is typically used to indicate the most specific category of which the entity is an instance." ;
    skos:exactMatch gff3:type,
        gpi:DB_Object_Type ;
    skos:inScheme biolink: .

biolink:volume a owl:DatatypeProperty ;
    rdfs:label "volume" ;
    rdfs:domain biolink:Publication ;
    rdfs:subPropertyOf biolink:node_property ;
    skos:definition "volume of a book or music release in a collection/series or a published collection of journal issues in a serial publication" ;
    skos:exactMatch WIKIDATA_PROPERTY:P478 ;
    skos:inScheme biolink: .

biolink:AgentTypeEnum a owl:Class ;
    rdfs:label "AgentTypeEnum" ;
    rdfs:subClassOf linkml:EnumDefinition ;
    owl:unionOf ( <https://w3id.org/biolink/vocab/AgentTypeEnum#manual_agent> <https://w3id.org/biolink/vocab/AgentTypeEnum#automated_agent> <https://w3id.org/biolink/vocab/AgentTypeEnum#data_analysis_pipeline> <https://w3id.org/biolink/vocab/AgentTypeEnum#computational_model> <https://w3id.org/biolink/vocab/AgentTypeEnum#text_mining_agent> <https://w3id.org/biolink/vocab/AgentTypeEnum#image_processing_agent> <https://w3id.org/biolink/vocab/AgentTypeEnum#manual_validation_of_automated_agent> <https://w3id.org/biolink/vocab/AgentTypeEnum#not_provided> ) ;
    skos:definition "An enumeration of agent types responsible for generating a statement of knowledge, as defined by the Translator Knowledge Level / Agent Type (KL/AT) standard. Values distinguish human (manual) agents from automated agents (including data analysis pipelines, computational models, text-mining agents, image-processing agents) and mixed cases such as manual validation of automated output." ;
    skos:inScheme biolink: ;
    linkml:permissible_values <https://w3id.org/biolink/vocab/AgentTypeEnum#automated_agent>,
        <https://w3id.org/biolink/vocab/AgentTypeEnum#computational_model>,
        <https://w3id.org/biolink/vocab/AgentTypeEnum#data_analysis_pipeline>,
        <https://w3id.org/biolink/vocab/AgentTypeEnum#image_processing_agent>,
        <https://w3id.org/biolink/vocab/AgentTypeEnum#manual_agent>,
        <https://w3id.org/biolink/vocab/AgentTypeEnum#manual_validation_of_automated_agent>,
        <https://w3id.org/biolink/vocab/AgentTypeEnum#not_provided>,
        <https://w3id.org/biolink/vocab/AgentTypeEnum#text_mining_agent> .

<https://w3id.org/biolink/vocab/CausalMechanismQualifierEnum#inhibition> a owl:Class ;
    rdfs:label "inhibition" ;
    rdfs:subClassOf biolink:CausalMechanismQualifierEnum,
        <https://w3id.org/biolink/vocab/CausalMechanismQualifierEnum#negative_modulation> ;
    skos:closeMatch SEMMEDDB:INHIBITS,
        DGIdb:inhibitor ;
    skos:definition "A negative modulation mechanism in which the effector binds to the target and negatively effects its normal function, e.g. prevention of enzymatic reaction or activation of downstream pathway." ;
    skos:narrowMatch DGIdb:blocker,
        DGIdb:channel_blocker,
        DGIdb:gating_inhibitor,
        DGIdb:negative_modulator,
        CHEMBL.MECHANISM:antisense_inhibitor,
        CHEMBL.MECHANISM:blocker,
        CHEMBL.MECHANISM:inhibitor,
        CHEMBL.MECHANISM:negative_allosteric_modulator,
        CHEMBL.MECHANISM:negative_modulator .

<https://w3id.org/biolink/vocab/CausalMechanismQualifierEnum#negative_modulation> a owl:Class ;
    rdfs:label "negative_modulation" ;
    rdfs:subClassOf biolink:CausalMechanismQualifierEnum,
        <https://w3id.org/biolink/vocab/CausalMechanismQualifierEnum#modulation> ;
    skos:definition "A modulation mechanism that negatively effects the normal functioning of a target by decreasing or impeding its activity or abundance, or its sensitivity to other factors that do so." ;
    skos:narrowMatch DGIdb:negative_modulator .

biolink:EntityToPhenotypicFeatureAssociationMixin a owl:Class ;
    rdfs:label "entity to phenotypic feature association mixin" ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:onProperty linkml:mixins ;
            owl:someValuesFrom biolink:FrequencyQuantifier ],
        biolink:EntityToDiseaseOrPhenotypicFeatureAssociationMixin ;
    skos:definition "A mixin applied to any association whose object (target node) is a phenotypic feature." ;
    skos:inScheme biolink: .

biolink:Genotype a owl:Class ;
    rdfs:label "genotype" ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:minCardinality 0 ;
            owl:onProperty biolink:has_zygosity ],
        [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:has_zygosity ],
        [ a owl:Restriction ;
            owl:onProperty linkml:mixins ;
            owl:someValuesFrom biolink:OntologyClass ],
        [ a owl:Restriction ;
            owl:onProperty linkml:mixins ;
            owl:someValuesFrom biolink:GenomicEntity ],
        [ a owl:Restriction ;
            owl:onProperty linkml:mixins ;
            owl:someValuesFrom biolink:PhysicalEssence ],
        [ a owl:Restriction ;
            owl:allValuesFrom biolink:Zygosity ;
            owl:onProperty biolink:has_zygosity ],
        biolink:BiologicalEntity ;
    skos:definition "An information content entity that describes a genome by specifying the total variation in genomic sequence and/or gene expression, relative to some established background" ;
    skos:exactMatch <http://purl.obolibrary.org/obo/GENO_0000536>,
        SIO:001079 ;
    skos:inScheme biolink: ;
    skos:note "Consider renaming as genotypic entity" .

biolink:Outcome a owl:Class ;
    rdfs:label "outcome" ;
    rdfs:subClassOf <https://w3id.org/linkml/ClassDefinition#Mixin> ;
    skos:definition "An entity that has the role of being the consequence of an exposure event. This is an abstract mixin grouping of various categories of possible biological or non-biological outcomes." ;
    skos:inScheme biolink: .

biolink:PhenotypicFeature a owl:Class ;
    rdfs:label "phenotypic feature" ;
    rdfs:subClassOf biolink:DiseaseOrPhenotypicFeature ;
    skos:altLabel "endophenotype",
        "phenotype",
        "sign",
        "symptom",
        "trait" ;
    skos:broadMatch <http://purl.obolibrary.org/obo/BFO_0000019>,
        <http://purl.obolibrary.org/obo/PATO_0000001> ;
    skos:definition "A combination of entity and quality that makes up a phenotyping statement. An observable characteristic of an individual often resulting from the interaction of its genotype with its molecular and physical environment." ;
    skos:exactMatch MESH:D010641,
        <http://identifiers.org/umls/C4021819>,
        <http://purl.obolibrary.org/obo/NCIT_C16977>,
        <http://purl.obolibrary.org/obo/UPHENO_0001001>,
        SIO:010056,
        SNOMEDCT:8116006,
        WIKIDATA:Q104053 ;
    skos:inScheme biolink: ;
    skos:narrowMatch STY:T184,
        STY:T190,
        <http://purl.obolibrary.org/obo/APO_0000017>,
        <http://purl.obolibrary.org/obo/FBcv_0001347>,
        FYPO:0000001,
        <http://purl.obolibrary.org/obo/HP_0000118>,
        <http://purl.obolibrary.org/obo/MP_0000001>,
        <http://purl.obolibrary.org/obo/TO_0000387>,
        <http://purl.obolibrary.org/obo/WBPhenotype_0000886>,
        XPO:00000000,
        <http://purl.obolibrary.org/obo/ZP_00000000>,
        WIKIDATA:Q169872,
        WIKIDATA:Q25203551 .

biolink:Transcript a owl:Class ;
    rdfs:label "transcript" ;
    rdfs:subClassOf biolink:BiologicalEntity ;
    skos:definition "An RNA synthesized on a DNA or RNA template by an RNA polymerase." ;
    skos:exactMatch <http://purl.obolibrary.org/obo/SO_0000673>,
        SIO:010450,
        dcid:RNATranscript,
        WIKIDATA:Q7243183 ;
    skos:inScheme biolink: .

biolink:NucleicAcidEntity a owl:Class ;
    rdfs:label "nucleic acid entity" ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:onProperty linkml:mixins ;
            owl:someValuesFrom biolink:ThingWithTaxon ],
        [ a owl:Restriction ;
            owl:onProperty linkml:mixins ;
            owl:someValuesFrom biolink:PhysicalEssence ],
        [ a owl:Restriction ;
            owl:onProperty linkml:mixins ;
            owl:someValuesFrom biolink:OntologyClass ],
        [ a owl:Restriction ;
            owl:onProperty linkml:mixins ;
            owl:someValuesFrom biolink:GenomicEntity ],
        biolink:MolecularEntity ;
    skos:altLabel "genomic entity",
        "sequence feature" ;
    skos:definition "A nucleic acid entity is a molecular entity characterized by availability in gene databases of nucleotide-based sequence representations of its precise sequence; for convenience of representation, partial sequences of various kinds are included." ;
    skos:exactMatch <http://purl.obolibrary.org/obo/SO_0000110> ;
    skos:inScheme biolink: ;
    skos:narrowMatch STY:T086,
        STY:T114 .

biolink:PopulationOfIndividualOrganisms a owl:Class ;
    rdfs:label "population of individual organisms" ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:onProperty linkml:mixins ;
            owl:someValuesFrom biolink:SubjectOfInvestigation ],
        biolink:OrganismalEntity ;
    skos:definition "A collection of individuals from the same taxonomic class distinguished by one or more characteristics.  Characteristics can include, but are not limited to, shared geographic location, genetics, phenotypes." ;
    skos:exactMatch STY:T098,
        <http://purl.obolibrary.org/obo/OBI_0000181>,
        <http://purl.obolibrary.org/obo/PCO_0000001>,
        SIO:001061 ;
    skos:inScheme biolink: .

biolink:RetrievalSource a owl:Class ;
    rdfs:label "retrieval source" ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:allValuesFrom xsd:anyURI ;
            owl:onProperty biolink:xref ],
        [ a owl:Restriction ;
            owl:minCardinality 0 ;
            owl:onProperty biolink:xref ],
        [ a owl:Restriction ;
            owl:allValuesFrom xsd:anyURI ;
            owl:onProperty biolink:source_record_urls ],
        [ a owl:Restriction ;
            owl:minCardinality 0 ;
            owl:onProperty biolink:source_record_urls ],
        [ a owl:Restriction ;
            owl:allValuesFrom biolink:ResourceRoleEnum ;
            owl:onProperty biolink:resource_role ],
        [ a owl:Restriction ;
            owl:allValuesFrom xsd:anyURI ;
            owl:onProperty biolink:upstream_resource_ids ],
        [ a owl:Restriction ;
            owl:allValuesFrom xsd:anyURI ;
            owl:onProperty biolink:resource_id ],
        [ a owl:Restriction ;
            owl:minCardinality 1 ;
            owl:onProperty biolink:resource_id ],
        [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:resource_id ],
        [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:resource_role ],
        [ a owl:Restriction ;
            owl:minCardinality 1 ;
            owl:onProperty biolink:resource_role ],
        [ a owl:Restriction ;
            owl:minCardinality 0 ;
            owl:onProperty biolink:upstream_resource_ids ],
        biolink:InformationContentEntity ;
    skos:definition "Provides information about how a particular InformationResource served as a source from which knowledge expressed in an Edge, or data used to generate this knowledge, was retrieved." ;
    skos:inScheme biolink: .

biolink:xref a owl:DatatypeProperty ;
    rdfs:label "xref" ;
    rdfs:domain biolink:NamedThing ;
    rdfs:range xsd:anyURI ;
    skos:altLabel "DbXref",
        "Dbxref",
        "dbxref",
        "record_url",
        "source_record_urls" ;
    skos:definition "A database cross reference or alternative identifier for a NamedThing or edge between two NamedThings.  This property should point to a database record or webpage that supports the existence of the edge, or gives more detail about the edge. This property can be used on a node or edge to provide multiple URIs or CURIE cross references." ;
    skos:inScheme biolink: ;
    skos:narrowMatch gff3:Dbxref,
        gpi:DB_Xrefs .

biolink:StudyResult a owl:Class ;
    rdfs:label "study result" ;
    rdfs:subClassOf [ owl:unionOf ( biolink:ChiSquaredAnalysisResult biolink:ConceptCountAnalysisResult biolink:IceesStudyResult biolink:LogOddsAnalysisResult biolink:ObservedExpectedFrequencyAnalysisResult biolink:ProteinLigandAssayResult biolink:RelativeFrequencyAnalysisResult biolink:TextMiningStudyResult ) ],
        biolink:NamedThing ;
    skos:definition "A collection of data items from a study that are about a particular study subject or experimental unit (the 'focus' of the Result) - optionally with context/provenance metadata that may be relevant to the interpretation of this data as evidence." ;
    skos:editorialNote "The data/metadata included in a Study Result object are typically a subset of data from a larger study data set, that are selected by a curator because they may be useful as evidence for deriving knowledge about a specific focus of the study. The notion of a 'study' here is defined broadly to include any research activity at any scale that is aimed at generating knowledge or hypotheses. This may include a single assay or computational analyses, or a larger scale clinical trial or experimental research investigation." ;
    skos:inScheme biolink: .

biolink:SubjectOfInvestigation a owl:Class ;
    rdfs:label "subject of investigation" ;
    rdfs:subClassOf <https://w3id.org/linkml/ClassDefinition#Mixin> ;
    skos:definition "An entity that has the role of being studied in an investigation, study, or experiment" ;
    skos:inScheme biolink: .

biolink:allelic_requirement a owl:DatatypeProperty ;
    rdfs:label "allelic requirement" ;
    rdfs:range [ a rdfs:Datatype ;
            owl:intersectionOf ( xsd:string [ a rdfs:Datatype ;
                        owl:onDatatype xsd:string ;
                        owl:withRestrictions ( [ xsd:pattern "^HP:\\d{7}$" ] ) ] ) ] ;
    rdfs:subPropertyOf biolink:association_slot ;
    skos:definition "The allele configuration of a particular gene or variant required for the expression of a disease or phenotype in a specific patient or instance." ;
    skos:inScheme biolink: ;
    skos:note "This edge property may be used by associations between Genes or SequenceVariants and DiseaseOrPhenotypicFeatures to provide the inheritance pattern and genetic context of the relationship. Terms from the HP mode of inheritance sub-ontology (HP:0000005) should be used in the value of this slot. This slot differs from the predicate \"has_mode_of_inheritance\", in that the predicate is used to link a disease or phenotype with its general inheritance pattern (how it is typically transmitted from one generation to the next, regardless of the specific genetic variant that is present in an individual or instance)." .

biolink:Entity a owl:Class ;
    rdfs:label "entity" ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:allValuesFrom xsd:string ;
            owl:onProperty biolink:description ],
        [ a owl:Restriction ;
            owl:minCardinality 0 ;
            owl:onProperty biolink:deprecated ],
        [ a owl:Restriction ;
            owl:allValuesFrom xsd:string ;
            owl:onProperty biolink:type ],
        [ a owl:Restriction ;
            owl:allValuesFrom xsd:string ;
            owl:onProperty biolink:name ],
        [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:description ],
        [ a owl:Restriction ;
            owl:minCardinality 0 ;
            owl:onProperty biolink:category ],
        [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:name ],
        [ a owl:Restriction ;
            owl:minCardinality 0 ;
            owl:onProperty biolink:iri ],
        [ a owl:Restriction ;
            owl:minCardinality 1 ;
            owl:onProperty biolink:id ],
        [ a owl:Restriction ;
            owl:minCardinality 0 ;
            owl:onProperty biolink:name ],
        [ a owl:Restriction ;
            owl:minCardinality 0 ;
            owl:onProperty biolink:has_attribute ],
        [ a owl:Restriction ;
            owl:allValuesFrom xsd:anyURI ;
            owl:onProperty biolink:category ],
        [ owl:unionOf ( biolink:Association biolink:NamedThing ) ],
        [ a owl:Restriction ;
            owl:allValuesFrom xsd:string ;
            owl:onProperty biolink:iri ],
        [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:deprecated ],
        [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:id ],
        [ a owl:Restriction ;
            owl:minCardinality 0 ;
            owl:onProperty biolink:description ],
        [ a owl:Restriction ;
            owl:allValuesFrom biolink:Attribute ;
            owl:onProperty biolink:has_attribute ],
        [ a owl:Restriction ;
            owl:allValuesFrom xsd:string ;
            owl:onProperty biolink:id ],
        [ a owl:Restriction ;
            owl:minCardinality 0 ;
            owl:onProperty biolink:type ],
        [ a owl:Restriction ;
            owl:allValuesFrom xsd:boolean ;
            owl:onProperty biolink:deprecated ],
        [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:iri ],
        linkml:ClassDefinition ;
    skos:definition "Root Biolink Model class for all things and informational relationships, real or imagined." ;
    skos:inScheme biolink: .

biolink:OrganismalEntity a owl:Class ;
    rdfs:label "organismal entity" ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:allValuesFrom owl:Thing ;
            owl:onProperty biolink:has_attribute ],
        [ a owl:Restriction ;
            owl:minCardinality 0 ;
            owl:onProperty biolink:has_attribute ],
        [ owl:unionOf ( biolink:AnatomicalEntity biolink:Bacterium biolink:CellLine biolink:CellularOrganism biolink:IndividualOrganism biolink:LifeStage biolink:PopulationOfIndividualOrganisms biolink:Virus ) ],
        [ a owl:Restriction ;
            owl:onProperty linkml:mixins ;
            owl:someValuesFrom biolink:SubjectOfInvestigation ],
        biolink:BiologicalEntity ;
    skos:definition "A named entity that is either a part of an organism, a whole organism, population or clade of organisms, excluding chemical entities" ;
    skos:exactMatch <http://purl.obolibrary.org/obo/CARO_0001010>,
        UMLSSG:LIVB,
        WIKIDATA:Q7239 ;
    skos:inScheme biolink: ;
    skos:narrowMatch STY:T008 .

biolink:ResearchPhaseEnum a owl:Class ;
    rdfs:label "ResearchPhaseEnum" ;
    rdfs:subClassOf linkml:EnumDefinition ;
    owl:unionOf ( <https://w3id.org/biolink/vocab/ResearchPhaseEnum#pre_clinical_research_phase> <https://w3id.org/biolink/vocab/ResearchPhaseEnum#clinical_trial_phase> <https://w3id.org/biolink/vocab/ResearchPhaseEnum#clinical_trial_phase_1> <https://w3id.org/biolink/vocab/ResearchPhaseEnum#clinical_trial_phase_1_to_2> <https://w3id.org/biolink/vocab/ResearchPhaseEnum#clinical_trial_phase_2> <https://w3id.org/biolink/vocab/ResearchPhaseEnum#clinical_trial_phase_2_to_3> <https://w3id.org/biolink/vocab/ResearchPhaseEnum#clinical_trial_phase_3> <https://w3id.org/biolink/vocab/ResearchPhaseEnum#clinical_trial_phase_4> <https://w3id.org/biolink/vocab/ResearchPhaseEnum#not_provided> ) ;
    skos:definition "An enumeration of research phases describing the stage of investigation for a drug or therapy, spanning preclinical research through clinical trial phases 1 through 4 (including phase 1/2 and phase 2/3 combinations)." ;
    skos:inScheme biolink: ;
    linkml:permissible_values <https://w3id.org/biolink/vocab/ResearchPhaseEnum#clinical_trial_phase>,
        <https://w3id.org/biolink/vocab/ResearchPhaseEnum#clinical_trial_phase_1>,
        <https://w3id.org/biolink/vocab/ResearchPhaseEnum#clinical_trial_phase_1_to_2>,
        <https://w3id.org/biolink/vocab/ResearchPhaseEnum#clinical_trial_phase_2>,
        <https://w3id.org/biolink/vocab/ResearchPhaseEnum#clinical_trial_phase_2_to_3>,
        <https://w3id.org/biolink/vocab/ResearchPhaseEnum#clinical_trial_phase_3>,
        <https://w3id.org/biolink/vocab/ResearchPhaseEnum#clinical_trial_phase_4>,
        <https://w3id.org/biolink/vocab/ResearchPhaseEnum#not_provided>,
        <https://w3id.org/biolink/vocab/ResearchPhaseEnum#pre_clinical_research_phase> .

biolink:Attribute a owl:Class ;
    rdfs:label "attribute" ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:minCardinality 0 ;
            owl:onProperty biolink:has_quantitative_value ],
        [ a owl:Restriction ;
            owl:allValuesFrom biolink:NamedThing ;
            owl:onProperty biolink:has_qualitative_value ],
        [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:has_attribute_type ],
        [ a owl:Restriction ;
            owl:allValuesFrom xsd:string ;
            owl:onProperty biolink:iri ],
        [ a owl:Restriction ;
            owl:allValuesFrom biolink:QuantityValue ;
            owl:onProperty biolink:has_quantitative_value ],
        [ a owl:Restriction ;
            owl:minCardinality 0 ;
            owl:onProperty biolink:has_qualitative_value ],
        [ a owl:Restriction ;
            owl:onProperty linkml:mixins ;
            owl:someValuesFrom biolink:OntologyClass ],
        [ a owl:Restriction ;
            owl:minCardinality 1 ;
            owl:onProperty biolink:has_attribute_type ],
        [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:iri ],
        [ a owl:Restriction ;
            owl:allValuesFrom biolink:OntologyClass ;
            owl:onProperty biolink:has_attribute_type ],
        [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:name ],
        [ a owl:Restriction ;
            owl:minCardinality 0 ;
            owl:onProperty biolink:name ],
        [ a owl:Restriction ;
            owl:minCardinality 0 ;
            owl:onProperty biolink:iri ],
        [ a owl:Restriction ;
            owl:allValuesFrom xsd:string ;
            owl:onProperty biolink:name ],
        [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:has_qualitative_value ],
        biolink:NamedThing ;
    skos:definition "A property or characteristic of an entity. For example, an apple may have properties such as color, shape, age, crispiness. An environmental sample may have attributes such as depth, lat, long, material." ;
    skos:exactMatch SIO:000614 ;
    skos:inScheme biolink: .

biolink:EntityToDiseaseAssociationMixin a owl:Class ;
    rdfs:label "entity to disease association mixin" ;
    rdfs:subClassOf biolink:EntityToDiseaseOrPhenotypicFeatureAssociationMixin ;
    skos:definition "mixin class for any association whose object (target node) is a disease" ;
    skos:inScheme biolink: .

biolink:ClinicalTrial a owl:Class ;
    rdfs:label "clinical trial" ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:allValuesFrom xsd:string ;
            owl:onProperty biolink:clinical_trial_brief_title ],
        [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:clinical_trial_age_range ],
        [ a owl:Restriction ;
            owl:minCardinality 0 ;
            owl:onProperty biolink:clinical_trial_tested_intervention ],
        [ a owl:Restriction ;
            owl:minCardinality 0 ;
            owl:onProperty biolink:clinical_trial_age_range ],
        [ a owl:Restriction ;
            owl:minCardinality 0 ;
            owl:onProperty biolink:clinical_trial_enrollment_type ],
        [ a owl:Restriction ;
            owl:allValuesFrom xsd:string ;
            owl:onProperty biolink:clinical_trial_intervention_model ],
        [ a owl:Restriction ;
            owl:allValuesFrom xsd:date ;
            owl:onProperty biolink:creation_date ],
        [ a owl:Restriction ;
            owl:minCardinality 0 ;
            owl:onProperty biolink:clinical_trial_overall_status ],
        [ a owl:Restriction ;
            owl:allValuesFrom biolink:ClinicalTrialStatusEnum ;
            owl:onProperty biolink:clinical_trial_overall_status ],
        [ a owl:Restriction ;
            owl:allValuesFrom biolink:ClinicalTrialAgeStageEnum ;
            owl:onProperty biolink:clinical_trial_age_stage ],
        [ a owl:Restriction ;
            owl:minCardinality 0 ;
            owl:onProperty biolink:clinical_trial_phase ],
        [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:clinical_trial_enrollment ],
        [ a owl:Restriction ;
            owl:minCardinality 0 ;
            owl:onProperty biolink:clinical_trial_age_stage ],
        [ a owl:Restriction ;
            owl:allValuesFrom xsd:integer ;
            owl:onProperty biolink:clinical_trial_enrollment ],
        [ a owl:Restriction ;
            owl:minCardinality 0 ;
            owl:onProperty biolink:clinical_trial_conditions ],
        [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:clinical_trial_intervention_model ],
        [ a owl:Restriction ;
            owl:minCardinality 0 ;
            owl:onProperty biolink:clinical_trial_start_date ],
        [ a owl:Restriction ;
            owl:minCardinality 0 ;
            owl:onProperty biolink:clinical_trial_enrollment ],
        [ a owl:Restriction ;
            owl:minCardinality 0 ;
            owl:onProperty biolink:clinical_trial_intervention_model ],
        [ a owl:Restriction ;
            owl:allValuesFrom xsd:string ;
            owl:onProperty biolink:clinical_trial_primary_purpose ],
        [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:clinical_trial_overall_status ],
        [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:clinical_trial_enrollment_type ],
        [ a owl:Restriction ;
            owl:allValuesFrom biolink:ClinicalIntervention ;
            owl:onProperty biolink:clinical_trial_interventions ],
        [ a owl:Restriction ;
            owl:allValuesFrom biolink:DiseaseOrPhenotypicFeature ;
            owl:onProperty biolink:clinical_trial_conditions ],
        [ a owl:Restriction ;
            owl:minCardinality 0 ;
            owl:onProperty biolink:creation_date ],
        [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:clinical_trial_start_date ],
        [ a owl:Restriction ;
            owl:allValuesFrom xsd:string ;
            owl:onProperty biolink:clinical_trial_start_date ],
        [ a owl:Restriction ;
            owl:minCardinality 0 ;
            owl:onProperty biolink:clinical_trial_brief_title ],
        [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:clinical_trial_phase ],
        [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:clinical_trial_brief_title ],
        [ a owl:Restriction ;
            owl:allValuesFrom xsd:string ;
            owl:onProperty biolink:clinical_trial_age_range ],
        [ a owl:Restriction ;
            owl:allValuesFrom xsd:string ;
            owl:onProperty biolink:clinical_trial_tested_intervention ],
        [ a owl:Restriction ;
            owl:minCardinality 0 ;
            owl:onProperty biolink:clinical_trial_primary_purpose ],
        [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:clinical_trial_primary_purpose ],
        [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:clinical_trial_tested_intervention ],
        [ a owl:Restriction ;
            owl:minCardinality 0 ;
            owl:onProperty biolink:clinical_trial_interventions ],
        [ a owl:Restriction ;
            owl:allValuesFrom xsd:string ;
            owl:onProperty biolink:clinical_trial_enrollment_type ],
        [ a owl:Restriction ;
            owl:allValuesFrom biolink:ResearchPhaseEnum ;
            owl:onProperty biolink:clinical_trial_phase ],
        [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:creation_date ],
        biolink:Study ;
    skos:definition "A clinical trial is a research study that prospectively assigns human participants or groups of humans to one or more health-related interventions to evaluate the effects on health outcomes." ;
    skos:exactMatch <http://purl.obolibrary.org/obo/NCIT_C71104>,
        SIO:001000 ;
    skos:inScheme biolink: .

biolink:ClinicalTrialStatusEnum a owl:Class ;
    rdfs:label "ClinicalTrialStatusEnum" ;
    rdfs:subClassOf linkml:EnumDefinition ;
    owl:unionOf ( <https://w3id.org/biolink/vocab/ClinicalTrialStatusEnum#ACTIVE_NOT_RECRUITING> <https://w3id.org/biolink/vocab/ClinicalTrialStatusEnum#APPROVED_FOR_MARKETING> <https://w3id.org/biolink/vocab/ClinicalTrialStatusEnum#AVAILABLE> <https://w3id.org/biolink/vocab/ClinicalTrialStatusEnum#COMPLETED> <https://w3id.org/biolink/vocab/ClinicalTrialStatusEnum#ENROLLING_BY_INVITATION> <https://w3id.org/biolink/vocab/ClinicalTrialStatusEnum#NO_LONGER_AVAILABLE> <https://w3id.org/biolink/vocab/ClinicalTrialStatusEnum#NOT_YET_RECRUITING> <https://w3id.org/biolink/vocab/ClinicalTrialStatusEnum#RECRUITING> <https://w3id.org/biolink/vocab/ClinicalTrialStatusEnum#SUSPENDED> <https://w3id.org/biolink/vocab/ClinicalTrialStatusEnum#TEMPORARILY_NOT_AVAILABLE> <https://w3id.org/biolink/vocab/ClinicalTrialStatusEnum#TERMINATED> <https://w3id.org/biolink/vocab/ClinicalTrialStatusEnum#UNKNOWN> <https://w3id.org/biolink/vocab/ClinicalTrialStatusEnum#WITHDRAWN> ) ;
    skos:definition """Enumeration of clinical trial statuses indicating the recruitment state, availability, or regulatory status of a clinical study or intervention.
""" ;
    skos:inScheme biolink: ;
    linkml:permissible_values <https://w3id.org/biolink/vocab/ClinicalTrialStatusEnum#ACTIVE_NOT_RECRUITING>,
        <https://w3id.org/biolink/vocab/ClinicalTrialStatusEnum#APPROVED_FOR_MARKETING>,
        <https://w3id.org/biolink/vocab/ClinicalTrialStatusEnum#AVAILABLE>,
        <https://w3id.org/biolink/vocab/ClinicalTrialStatusEnum#COMPLETED>,
        <https://w3id.org/biolink/vocab/ClinicalTrialStatusEnum#ENROLLING_BY_INVITATION>,
        <https://w3id.org/biolink/vocab/ClinicalTrialStatusEnum#NOT_YET_RECRUITING>,
        <https://w3id.org/biolink/vocab/ClinicalTrialStatusEnum#NO_LONGER_AVAILABLE>,
        <https://w3id.org/biolink/vocab/ClinicalTrialStatusEnum#RECRUITING>,
        <https://w3id.org/biolink/vocab/ClinicalTrialStatusEnum#SUSPENDED>,
        <https://w3id.org/biolink/vocab/ClinicalTrialStatusEnum#TEMPORARILY_NOT_AVAILABLE>,
        <https://w3id.org/biolink/vocab/ClinicalTrialStatusEnum#TERMINATED>,
        <https://w3id.org/biolink/vocab/ClinicalTrialStatusEnum#UNKNOWN>,
        <https://w3id.org/biolink/vocab/ClinicalTrialStatusEnum#WITHDRAWN> .

biolink:GeneOrGeneProductOrChemicalPartQualifierEnum a owl:Class ;
    rdfs:label "GeneOrGeneProductOrChemicalPartQualifierEnum" ;
    rdfs:subClassOf linkml:EnumDefinition ;
    owl:unionOf ( <https://w3id.org/biolink/vocab/GeneOrGeneProductOrChemicalPartQualifierEnum#3_prime_utr> <https://w3id.org/biolink/vocab/GeneOrGeneProductOrChemicalPartQualifierEnum#5_prime_utr> <https://w3id.org/biolink/vocab/GeneOrGeneProductOrChemicalPartQualifierEnum#polya_tail> <https://w3id.org/biolink/vocab/GeneOrGeneProductOrChemicalPartQualifierEnum#promoter> <https://w3id.org/biolink/vocab/GeneOrGeneProductOrChemicalPartQualifierEnum#enhancer> <https://w3id.org/biolink/vocab/GeneOrGeneProductOrChemicalPartQualifierEnum#exon> <https://w3id.org/biolink/vocab/GeneOrGeneProductOrChemicalPartQualifierEnum#intron> ) ;
    skos:definition "An enumeration used as a qualifier to indicate a particular structural or functional part of a gene, gene product, or chemical (e.g., 3' UTR, 5' UTR, poly-A tail, promoter, enhancer, exon, or intron)." ;
    skos:inScheme biolink: ;
    linkml:permissible_values <https://w3id.org/biolink/vocab/GeneOrGeneProductOrChemicalPartQualifierEnum#3_prime_utr>,
        <https://w3id.org/biolink/vocab/GeneOrGeneProductOrChemicalPartQualifierEnum#5_prime_utr>,
        <https://w3id.org/biolink/vocab/GeneOrGeneProductOrChemicalPartQualifierEnum#enhancer>,
        <https://w3id.org/biolink/vocab/GeneOrGeneProductOrChemicalPartQualifierEnum#exon>,
        <https://w3id.org/biolink/vocab/GeneOrGeneProductOrChemicalPartQualifierEnum#intron>,
        <https://w3id.org/biolink/vocab/GeneOrGeneProductOrChemicalPartQualifierEnum#polya_tail>,
        <https://w3id.org/biolink/vocab/GeneOrGeneProductOrChemicalPartQualifierEnum#promoter> .

biolink:PhysicalEssence a owl:Class ;
    rdfs:label "physical essence" ;
    rdfs:subClassOf biolink:PhysicalEssenceOrOccurrent ;
    skos:definition "Semantic mixin concept.  Pertains to entities that have physical properties such as mass, volume, or charge." ;
    skos:inScheme biolink: .

biolink:name a owl:DatatypeProperty ;
    rdfs:label "name" ;
    rdfs:domain biolink:Entity ;
    rdfs:range xsd:string ;
    skos:altLabel "display name",
        "label",
        "title" ;
    skos:definition "A human-readable name for an attribute or entity." ;
    skos:exactMatch gff3:Name,
        gpi:DB_Object_Name ;
    skos:inScheme biolink: ;
    skos:narrowMatch dct:title,
        WIKIDATA_PROPERTY:P1476 .

biolink:Agent a owl:Class ;
    rdfs:label "agent" ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:minCardinality 0 ;
            owl:onProperty biolink:address ],
        [ a owl:Restriction ;
            owl:minCardinality 1 ;
            owl:onProperty biolink:id ],
        [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:id ],
        [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:address ],
        [ a owl:Restriction ;
            owl:allValuesFrom xsd:string ;
            owl:onProperty biolink:name ],
        [ a owl:Restriction ;
            owl:minCardinality 0 ;
            owl:onProperty biolink:name ],
        [ a owl:Restriction ;
            owl:allValuesFrom xsd:string ;
            owl:onProperty biolink:id ],
        [ a owl:Restriction ;
            owl:allValuesFrom xsd:anyURI ;
            owl:onProperty biolink:affiliation ],
        [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:name ],
        [ a owl:Restriction ;
            owl:allValuesFrom xsd:string ;
            owl:onProperty biolink:address ],
        [ a owl:Restriction ;
            owl:minCardinality 0 ;
            owl:onProperty biolink:affiliation ],
        biolink:AdministrativeEntity ;
    skos:altLabel "group" ;
    skos:definition "person, group, organization or project that provides a piece of information (i.e. a knowledge association)" ;
    skos:exactMatch dct:Agent,
        prov:Agent ;
    skos:inScheme biolink: ;
    skos:narrowMatch STY:T092,
        STY:T093,
        STY:T094,
        STY:T095,
        STY:T096,
        UMLSSG:ORGA .

biolink:anatomical_context_qualifier a owl:DatatypeProperty ;
    rdfs:label "anatomical context qualifier" ;
    rdfs:subPropertyOf biolink:statement_qualifier ;
    skos:definition "A statement qualifier representing an anatomical location where an relationship expressed in an association took place (can be a tissue, cell type, or sub-cellular location)." ;
    skos:editorialNote "Anatomical context values can be any term from UBERON. For example, the context qualifier ‘cerebral cortext’ combines with a core concept of ‘neuron’ to express the composed concept ‘neuron in the cerebral cortext’. The species_context_qualifier applies taxonomic context.  Ontology CURIEs are expected as values here, the examples below are intended to help clarify the content of the CURIEs." ;
    skos:inScheme biolink: .

biolink:Occurrent a owl:Class ;
    rdfs:label "occurrent" ;
    rdfs:subClassOf biolink:PhysicalEssenceOrOccurrent ;
    skos:definition "A processual entity." ;
    skos:exactMatch <http://purl.obolibrary.org/obo/BFO_0000003> ;
    skos:inScheme biolink: .

biolink:object_form_or_variant_qualifier a owl:DatatypeProperty ;
    rdfs:label "object form or variant qualifier" ;
    rdfs:subPropertyOf biolink:form_or_variant_qualifier ;
    skos:definition "A qualifier that composes with a core subject/object concept to define a specific type, variant, alternative version of this concept. The composed concept remains a subtype or instance of the core concept. For example, the qualifier ‘mutation’ combines with the core concept ‘Gene X’ to express the compose concept ‘a mutation of Gene X’.  This qualifier specifies a change in the object of an association (aka: statement)." ;
    skos:inScheme biolink: .

biolink:object_part_qualifier a owl:DatatypeProperty ;
    rdfs:label "object part qualifier" ;
    rdfs:subPropertyOf biolink:part_qualifier ;
    skos:definition "defines a specific part/component of the core concept (used in cases there this specific part has no IRI we can use to directly represent it).  This qualifier is for the object of an association (or statement)." ;
    skos:inScheme biolink: .

biolink:subject_derivative_qualifier a owl:DatatypeProperty ;
    rdfs:label "subject derivative qualifier" ;
    rdfs:subPropertyOf biolink:derivative_qualifier ;
    skos:definition "A qualifier that composes with a core subject/object  concept to describe something that is derived from the core concept.  For example, the qualifier ‘metabolite’ combines with a ‘Chemical X’ core concept to express the composed concept ‘a metabolite of Chemical X’.  This qualifier is for the subject of an association (or statement)." ;
    skos:inScheme biolink: .

biolink:subject_part_qualifier a owl:DatatypeProperty ;
    rdfs:label "subject part qualifier" ;
    rdfs:subPropertyOf biolink:part_qualifier ;
    skos:definition "defines a specific part/component of the core concept (used in cases there this specific part has no IRI we can use to directly represent it).  This qualifier is for the subject of an association (or statement)." ;
    skos:inScheme biolink: .

biolink:ApprovalStatusEnum a owl:Class ;
    rdfs:label "ApprovalStatusEnum" ;
    rdfs:subClassOf linkml:EnumDefinition ;
    owl:unionOf ( <https://w3id.org/biolink/vocab/ApprovalStatusEnum#discovery_and_development_phase> <https://w3id.org/biolink/vocab/ApprovalStatusEnum#preclinical_research_phase> <https://w3id.org/biolink/vocab/ApprovalStatusEnum#fda_clinical_research_phase> <https://w3id.org/biolink/vocab/ApprovalStatusEnum#fda_review_phase_4> <https://w3id.org/biolink/vocab/ApprovalStatusEnum#fda_post_market_safety_review> <https://w3id.org/biolink/vocab/ApprovalStatusEnum#fda_clinical_research_phase_1> <https://w3id.org/biolink/vocab/ApprovalStatusEnum#fda_clinical_research_phase_2> <https://w3id.org/biolink/vocab/ApprovalStatusEnum#fda_clinical_research_phase_3> <https://w3id.org/biolink/vocab/ApprovalStatusEnum#fda_clinical_research_phase_4> <https://w3id.org/biolink/vocab/ApprovalStatusEnum#fda_fast_track> <https://w3id.org/biolink/vocab/ApprovalStatusEnum#fda_breakthrough_therapy> <https://w3id.org/biolink/vocab/ApprovalStatusEnum#fda_accelerated_approval> <https://w3id.org/biolink/vocab/ApprovalStatusEnum#fda_priority_review> <https://w3id.org/biolink/vocab/ApprovalStatusEnum#regular_fda_approval> <https://w3id.org/biolink/vocab/ApprovalStatusEnum#post_approval_withdrawal> ) ;
    skos:definition "An enumeration of regulatory and development milestones for a drug or therapeutic, spanning discovery, preclinical research, FDA clinical trial phases (1-4), special review designations (e.g., fast track, breakthrough therapy, priority review), regular FDA approval, and post-approval withdrawal." ;
    skos:inScheme biolink: ;
    linkml:permissible_values <https://w3id.org/biolink/vocab/ApprovalStatusEnum#discovery_and_development_phase>,
        <https://w3id.org/biolink/vocab/ApprovalStatusEnum#fda_accelerated_approval>,
        <https://w3id.org/biolink/vocab/ApprovalStatusEnum#fda_breakthrough_therapy>,
        <https://w3id.org/biolink/vocab/ApprovalStatusEnum#fda_clinical_research_phase>,
        <https://w3id.org/biolink/vocab/ApprovalStatusEnum#fda_clinical_research_phase_1>,
        <https://w3id.org/biolink/vocab/ApprovalStatusEnum#fda_clinical_research_phase_2>,
        <https://w3id.org/biolink/vocab/ApprovalStatusEnum#fda_clinical_research_phase_3>,
        <https://w3id.org/biolink/vocab/ApprovalStatusEnum#fda_clinical_research_phase_4>,
        <https://w3id.org/biolink/vocab/ApprovalStatusEnum#fda_fast_track>,
        <https://w3id.org/biolink/vocab/ApprovalStatusEnum#fda_post_market_safety_review>,
        <https://w3id.org/biolink/vocab/ApprovalStatusEnum#fda_priority_review>,
        <https://w3id.org/biolink/vocab/ApprovalStatusEnum#fda_review_phase_4>,
        <https://w3id.org/biolink/vocab/ApprovalStatusEnum#post_approval_withdrawal>,
        <https://w3id.org/biolink/vocab/ApprovalStatusEnum#preclinical_research_phase>,
        <https://w3id.org/biolink/vocab/ApprovalStatusEnum#regular_fda_approval> .

biolink:Disease a owl:Class ;
    rdfs:label "disease" ;
    rdfs:subClassOf biolink:DiseaseOrPhenotypicFeature ;
    skos:altLabel "condition",
        "disorder",
        "medical condition" ;
    skos:definition "A disease is a disposition to undergo pathological processes that exists in an organism because of one or more disorders in that organism. A disorder of structure or function, especially one that produces specific signs, phenotypes or symptoms or that affects a specific location and is not simply a direct result of physical injury." ;
    skos:exactMatch STY:T047,
        <http://purl.obolibrary.org/obo/DOID_4>,
        <http://purl.obolibrary.org/obo/MONDO_0000001>,
        <http://purl.obolibrary.org/obo/NCIT_C2991>,
        SIO:010299,
        dcid:Disease,
        UMLSSG:DISO,
        WIKIDATA:Q12136 ;
    skos:inScheme biolink: ;
    skos:narrowMatch STY:T019,
        STY:T020,
        STY:T048,
        STY:T049,
        STY:T191,
        <http://purl.obolibrary.org/obo/MONDO_0042489> .

biolink:MolecularEntity a owl:Class ;
    rdfs:label "molecular entity" ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:onProperty linkml:mixins ;
            owl:someValuesFrom biolink:OntologyClass ],
        [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:is_metabolite ],
        [ a owl:Restriction ;
            owl:allValuesFrom xsd:boolean ;
            owl:onProperty biolink:is_metabolite ],
        [ a owl:Restriction ;
            owl:minCardinality 0 ;
            owl:onProperty biolink:is_metabolite ],
        biolink:ChemicalEntity ;
    skos:definition "A molecular entity is a chemical entity composed of individual or covalently bonded atoms." ;
    skos:inScheme biolink: ;
    skos:narrowMatch STY:T085,
        STY:T088,
        <http://purl.obolibrary.org/obo/CHEBI_23367>,
        bioschemas:MolecularEntity .

biolink:qualifier a owl:DatatypeProperty ;
    rdfs:label "qualifier" ;
    rdfs:subPropertyOf biolink:association_slot ;
    skos:definition "grouping slot for all qualifiers on an edge.  useful for testing compliance with association classes" ;
    skos:inScheme biolink: .

biolink:BiologicalProcessOrActivity a owl:Class ;
    rdfs:label "biological process or activity" ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:minCardinality 0 ;
            owl:onProperty biolink:has_input ],
        [ a owl:Restriction ;
            owl:allValuesFrom biolink:NamedThing ;
            owl:onProperty biolink:has_input ],
        [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:has_input ],
        [ a owl:Restriction ;
            owl:allValuesFrom biolink:PhysicalEntity ;
            owl:onProperty biolink:enabled_by ],
        [ a owl:Restriction ;
            owl:minCardinality 0 ;
            owl:onProperty biolink:enabled_by ],
        [ a owl:Restriction ;
            owl:onProperty linkml:mixins ;
            owl:someValuesFrom biolink:Occurrent ],
        [ a owl:Restriction ;
            owl:minCardinality 0 ;
            owl:onProperty biolink:has_output ],
        [ a owl:Restriction ;
            owl:onProperty linkml:mixins ;
            owl:someValuesFrom biolink:OntologyClass ],
        [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:enabled_by ],
        [ a owl:Restriction ;
            owl:allValuesFrom biolink:NamedThing ;
            owl:onProperty biolink:has_output ],
        [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:has_output ],
        biolink:BiologicalEntity ;
    skos:definition "Either an individual molecular activity, or a collection of causally connected molecular activities in a biological system." ;
    skos:inScheme biolink: .

biolink:ChemicalOrGeneOrGeneProductFormOrVariantEnum a owl:Class ;
    rdfs:label "ChemicalOrGeneOrGeneProductFormOrVariantEnum" ;
    rdfs:subClassOf linkml:EnumDefinition ;
    owl:unionOf ( <https://w3id.org/biolink/vocab/ChemicalOrGeneOrGeneProductFormOrVariantEnum#genetic_variant_form> <https://w3id.org/biolink/vocab/ChemicalOrGeneOrGeneProductFormOrVariantEnum#modified_form> <https://w3id.org/biolink/vocab/ChemicalOrGeneOrGeneProductFormOrVariantEnum#loss_of_function_variant_form> <https://w3id.org/biolink/vocab/ChemicalOrGeneOrGeneProductFormOrVariantEnum#non_loss_of_function_variant_form> <https://w3id.org/biolink/vocab/ChemicalOrGeneOrGeneProductFormOrVariantEnum#gain_of_function_variant_form> <https://w3id.org/biolink/vocab/ChemicalOrGeneOrGeneProductFormOrVariantEnum#dominant_negative_variant_form> <https://w3id.org/biolink/vocab/ChemicalOrGeneOrGeneProductFormOrVariantEnum#polymorphic_form> <https://w3id.org/biolink/vocab/ChemicalOrGeneOrGeneProductFormOrVariantEnum#snp_form> <https://w3id.org/biolink/vocab/ChemicalOrGeneOrGeneProductFormOrVariantEnum#mutant_form> <https://w3id.org/biolink/vocab/ChemicalOrGeneOrGeneProductFormOrVariantEnum#analog_form> ) ;
    skos:definition "An enumeration used as a qualifier to indicate a specific form or variant of a chemical, gene, or gene product involved in an association (e.g., modified form, loss-of-function variant, gain-of-function variant, dominant-negative variant, polymorphic form, SNP form, mutant form, or analog form)." ;
    skos:inScheme biolink: ;
    linkml:permissible_values <https://w3id.org/biolink/vocab/ChemicalOrGeneOrGeneProductFormOrVariantEnum#analog_form>,
        <https://w3id.org/biolink/vocab/ChemicalOrGeneOrGeneProductFormOrVariantEnum#dominant_negative_variant_form>,
        <https://w3id.org/biolink/vocab/ChemicalOrGeneOrGeneProductFormOrVariantEnum#gain_of_function_variant_form>,
        <https://w3id.org/biolink/vocab/ChemicalOrGeneOrGeneProductFormOrVariantEnum#genetic_variant_form>,
        <https://w3id.org/biolink/vocab/ChemicalOrGeneOrGeneProductFormOrVariantEnum#loss_of_function_variant_form>,
        <https://w3id.org/biolink/vocab/ChemicalOrGeneOrGeneProductFormOrVariantEnum#modified_form>,
        <https://w3id.org/biolink/vocab/ChemicalOrGeneOrGeneProductFormOrVariantEnum#mutant_form>,
        <https://w3id.org/biolink/vocab/ChemicalOrGeneOrGeneProductFormOrVariantEnum#non_loss_of_function_variant_form>,
        <https://w3id.org/biolink/vocab/ChemicalOrGeneOrGeneProductFormOrVariantEnum#polymorphic_form>,
        <https://w3id.org/biolink/vocab/ChemicalOrGeneOrGeneProductFormOrVariantEnum#snp_form> .

biolink:causal_mechanism_qualifier a owl:ObjectProperty ;
    rdfs:label "causal mechanism qualifier" ;
    rdfs:range biolink:CausalMechanismQualifierEnum ;
    rdfs:subPropertyOf biolink:statement_qualifier ;
    skos:definition "A statement qualifier representing a type of molecular control mechanism through which an effect of a chemical on a gene or gene product is mediated" ;
    skos:inScheme biolink: .

biolink:object_context_qualifier a owl:DatatypeProperty ;
    rdfs:label "object context qualifier" ;
    rdfs:subPropertyOf biolink:context_qualifier ;
    skos:definition "A qualifier describing the context in which the object of an association holds." ;
    skos:inScheme biolink: .

biolink:subject_context_qualifier a owl:DatatypeProperty ;
    rdfs:label "subject context qualifier" ;
    rdfs:subPropertyOf biolink:context_qualifier ;
    skos:definition "A qualifier describing the context in which the subject of an association holds." ;
    skos:inScheme biolink: .

biolink:InformationContentEntity a owl:Class ;
    rdfs:label "information content entity" ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:rights ],
        [ a owl:Restriction ;
            owl:allValuesFrom xsd:date ;
            owl:onProperty biolink:creation_date ],
        [ a owl:Restriction ;
            owl:minCardinality 0 ;
            owl:onProperty biolink:format ],
        [ a owl:Restriction ;
            owl:minCardinality 0 ;
            owl:onProperty biolink:rights ],
        [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:creation_date ],
        [ a owl:Restriction ;
            owl:allValuesFrom xsd:string ;
            owl:onProperty biolink:format ],
        [ a owl:Restriction ;
            owl:allValuesFrom xsd:string ;
            owl:onProperty biolink:license ],
        [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:format ],
        [ a owl:Restriction ;
            owl:allValuesFrom xsd:string ;
            owl:onProperty biolink:rights ],
        [ a owl:Restriction ;
            owl:minCardinality 0 ;
            owl:onProperty biolink:license ],
        [ a owl:Restriction ;
            owl:minCardinality 0 ;
            owl:onProperty biolink:creation_date ],
        [ owl:unionOf ( biolink:CommonDataElement biolink:ConfidenceLevel biolink:Dataset biolink:DatasetDistribution biolink:DatasetSummary biolink:DatasetVersion biolink:Evidence biolink:Publication biolink:RetrievalSource biolink:StudyVariable ) ],
        [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:license ],
        biolink:NamedThing ;
    skos:altLabel "information",
        "information artefact",
        "information entity" ;
    skos:definition "a piece of information that typically describes some topic of discourse or is used as support." ;
    skos:exactMatch IAO:0000030 ;
    skos:inScheme biolink: ;
    skos:narrowMatch STY:T077,
        STY:T078,
        STY:T079,
        STY:T080,
        STY:T081,
        STY:T082,
        STY:T089,
        STY:T102,
        STY:T169,
        STY:T171,
        STY:T185,
        UMLSSG:CONC .

biolink:QuantityValue a owl:Class ;
    rdfs:label "quantity value" ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:allValuesFrom <http://purl.obolibrary.org/obo/UO_0000000> ;
            owl:onProperty biolink:has_unit ],
        [ a owl:Restriction ;
            owl:minCardinality 0 ;
            owl:onProperty biolink:has_unit ],
        [ a owl:Restriction ;
            owl:allValuesFrom xsd:double ;
            owl:onProperty biolink:has_numeric_value ],
        [ a owl:Restriction ;
            owl:minCardinality 0 ;
            owl:onProperty biolink:has_numeric_value ],
        [ a owl:Restriction ;
            owl:minCardinality 0 ;
            owl:onProperty biolink:has_binary_relation ],
        [ a owl:Restriction ;
            owl:allValuesFrom biolink:BinaryRelationEnum ;
            owl:onProperty biolink:has_binary_relation ],
        [ a owl:Restriction ;
            owl:allValuesFrom <http://purl.obolibrary.org/obo/UO_0000046> ;
            owl:onProperty biolink:has_unit_prefix ],
        [ a owl:Restriction ;
            owl:minCardinality 0 ;
            owl:onProperty biolink:has_unit_prefix ],
        [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:has_unit_prefix ],
        [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:has_numeric_value ],
        [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:has_unit ],
        [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:has_binary_relation ],
        biolink:Annotation ;
    skos:definition "A value of an attribute that is quantitative and measurable, expressed as a combination of a unit, (optional) unit prefix and a numeric value. An optional binary relation qualifier may also be given, to allow capture of relative values, e.g., <1000.0 nM meaning \"less than 1000 nanometers\"" ;
    skos:inScheme biolink: .

biolink:BiologicalProcess a owl:Class ;
    rdfs:label "biological process" ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:onProperty linkml:mixins ;
            owl:someValuesFrom biolink:Occurrent ],
        [ a owl:Restriction ;
            owl:onProperty linkml:mixins ;
            owl:someValuesFrom biolink:OntologyClass ],
        biolink:BiologicalProcessOrActivity ;
    skos:broadMatch WIKIDATA:P682 ;
    skos:definition "One or more causally connected executions of molecular functions" ;
    skos:exactMatch <http://purl.obolibrary.org/obo/GO_0008150>,
        SIO:000006,
        WIKIDATA:Q2996394 ;
    skos:inScheme biolink: .

biolink:ExposureEvent a owl:Class ;
    rdfs:label "exposure event" ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:id ],
        [ a owl:Restriction ;
            owl:allValuesFrom xsd:string ;
            owl:onProperty biolink:exposure_additional_condition ],
        [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:exposure_route ],
        [ a owl:Restriction ;
            owl:minCardinality 0 ;
            owl:onProperty biolink:exposure_additional_condition ],
        [ a owl:Restriction ;
            owl:onProperty linkml:mixins ;
            owl:someValuesFrom biolink:OntologyClass ],
        [ a owl:Restriction ;
            owl:minCardinality 0 ;
            owl:onProperty biolink:exposure_route ],
        [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:exposure_end_age ],
        [ a owl:Restriction ;
            owl:allValuesFrom xsd:string ;
            owl:onProperty biolink:id ],
        [ a owl:Restriction ;
            owl:minCardinality 0 ;
            owl:onProperty biolink:exposure_vehicle ],
        [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:exposure_magnitude ],
        [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:timepoint ],
        [ a owl:Restriction ;
            owl:allValuesFrom xsd:string ;
            owl:onProperty biolink:exposure_type ],
        [ a owl:Restriction ;
            owl:minCardinality 0 ;
            owl:onProperty biolink:exposure_type ],
        [ a owl:Restriction ;
            owl:minCardinality 0 ;
            owl:onProperty biolink:exposure_duration ],
        [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:exposure_duration ],
        [ a owl:Restriction ;
            owl:allValuesFrom xsd:string ;
            owl:onProperty biolink:timepoint ],
        [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:exposure_type ],
        [ a owl:Restriction ;
            owl:allValuesFrom xsd:string ;
            owl:onProperty biolink:exposure_magnitude ],
        [ a owl:Restriction ;
            owl:minCardinality 0 ;
            owl:onProperty biolink:exposure_end_age ],
        [ a owl:Restriction ;
            owl:allValuesFrom xsd:integer ;
            owl:onProperty biolink:exposure_start_age ],
        [ a owl:Restriction ;
            owl:minCardinality 0 ;
            owl:onProperty biolink:exposure_magnitude ],
        [ a owl:Restriction ;
            owl:allValuesFrom xsd:integer ;
            owl:onProperty biolink:exposure_end_age ],
        [ a owl:Restriction ;
            owl:allValuesFrom xsd:time ;
            owl:onProperty biolink:exposure_duration ],
        [ a owl:Restriction ;
            owl:minCardinality 0 ;
            owl:onProperty biolink:exposure_start_age ],
        [ a owl:Restriction ;
            owl:allValuesFrom xsd:string ;
            owl:onProperty biolink:exposure_route ],
        [ a owl:Restriction ;
            owl:minCardinality 1 ;
            owl:onProperty biolink:id ],
        [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:exposure_additional_condition ],
        [ a owl:Restriction ;
            owl:allValuesFrom xsd:string ;
            owl:onProperty biolink:exposure_vehicle ],
        [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:exposure_vehicle ],
        [ a owl:Restriction ;
            owl:minCardinality 0 ;
            owl:onProperty biolink:timepoint ],
        [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:exposure_start_age ],
        biolink:NamedThing ;
    skos:altLabel "experimental condition",
        "exposure" ;
    skos:definition "A (possibly time bounded) incidence of a feature of the environment of an organism that influences one or more phenotypic features of that organism, potentially mediated by genes" ;
    skos:exactMatch <http://purl.obolibrary.org/obo/XCO_0000000> ;
    skos:inScheme biolink: .

<https://w3id.org/biolink/vocab/CausalMechanismQualifierEnum#molecular_modification> a owl:Class ;
    rdfs:label "molecular_modification" ;
    rdfs:subClassOf biolink:CausalMechanismQualifierEnum,
        <https://w3id.org/biolink/vocab/CausalMechanismQualifierEnum#modulation> ;
    skos:definition "A modulation mechanism through which an effect is mediated by the modification of a target, through addition of chemical moieties such phosphate groups, ubiquitin, lipids, etc., which alter its activity or cellular behavior." .

biolink:EffectTypeEnum a owl:Class ;
    rdfs:label "EffectTypeEnum" ;
    rdfs:subClassOf linkml:EnumDefinition ;
    owl:unionOf ( <https://w3id.org/biolink/vocab/EffectTypeEnum#regression_coefficient> <https://w3id.org/biolink/vocab/EffectTypeEnum#log2_fold_change> <https://w3id.org/biolink/vocab/EffectTypeEnum#wald_ratio> <https://w3id.org/biolink/vocab/EffectTypeEnum#inverse_variance_weighted> <https://w3id.org/biolink/vocab/EffectTypeEnum#mr_egger> <https://w3id.org/biolink/vocab/EffectTypeEnum#weighted_median> <https://w3id.org/biolink/vocab/EffectTypeEnum#standardized_mean_difference> <https://w3id.org/biolink/vocab/EffectTypeEnum#cohens_d> <https://w3id.org/biolink/vocab/EffectTypeEnum#hedges_g> <https://w3id.org/biolink/vocab/EffectTypeEnum#glasss_delta> <https://w3id.org/biolink/vocab/EffectTypeEnum#strictly_standardized_mean_difference> <https://w3id.org/biolink/vocab/EffectTypeEnum#correlation_coefficient> <https://w3id.org/biolink/vocab/EffectTypeEnum#pearsons_r> <https://w3id.org/biolink/vocab/EffectTypeEnum#spearmans_rho> <https://w3id.org/biolink/vocab/EffectTypeEnum#kendalls_tau> <https://w3id.org/biolink/vocab/EffectTypeEnum#polychoric_correlation> <https://w3id.org/biolink/vocab/EffectTypeEnum#matthews_correlation_coefficient> <https://w3id.org/biolink/vocab/EffectTypeEnum#goodman_kruskal_gamma> <https://w3id.org/biolink/vocab/EffectTypeEnum#r2_linkage_disequilibrium> <https://w3id.org/biolink/vocab/EffectTypeEnum#odds_ratio> <https://w3id.org/biolink/vocab/EffectTypeEnum#relative_risk> <https://w3id.org/biolink/vocab/EffectTypeEnum#hazard_ratio> <https://w3id.org/biolink/vocab/EffectTypeEnum#eta_squared> <https://w3id.org/biolink/vocab/EffectTypeEnum#omega_squared> <https://w3id.org/biolink/vocab/EffectTypeEnum#root_mean_square_standardized_effect> ) ;
    skos:definition "An enumeration of statistical metrics and estimators used to quantify the magnitude and direction of an effect or association between the subject and object of an edge. The numeric result is stored in the companion 'effect size' slot." ;
    skos:inScheme biolink: ;
    linkml:permissible_values <https://w3id.org/biolink/vocab/EffectTypeEnum#cohens_d>,
        <https://w3id.org/biolink/vocab/EffectTypeEnum#correlation_coefficient>,
        <https://w3id.org/biolink/vocab/EffectTypeEnum#eta_squared>,
        <https://w3id.org/biolink/vocab/EffectTypeEnum#glasss_delta>,
        <https://w3id.org/biolink/vocab/EffectTypeEnum#goodman_kruskal_gamma>,
        <https://w3id.org/biolink/vocab/EffectTypeEnum#hazard_ratio>,
        <https://w3id.org/biolink/vocab/EffectTypeEnum#hedges_g>,
        <https://w3id.org/biolink/vocab/EffectTypeEnum#inverse_variance_weighted>,
        <https://w3id.org/biolink/vocab/EffectTypeEnum#kendalls_tau>,
        <https://w3id.org/biolink/vocab/EffectTypeEnum#log2_fold_change>,
        <https://w3id.org/biolink/vocab/EffectTypeEnum#matthews_correlation_coefficient>,
        <https://w3id.org/biolink/vocab/EffectTypeEnum#mr_egger>,
        <https://w3id.org/biolink/vocab/EffectTypeEnum#odds_ratio>,
        <https://w3id.org/biolink/vocab/EffectTypeEnum#omega_squared>,
        <https://w3id.org/biolink/vocab/EffectTypeEnum#pearsons_r>,
        <https://w3id.org/biolink/vocab/EffectTypeEnum#polychoric_correlation>,
        <https://w3id.org/biolink/vocab/EffectTypeEnum#r2_linkage_disequilibrium>,
        <https://w3id.org/biolink/vocab/EffectTypeEnum#regression_coefficient>,
        <https://w3id.org/biolink/vocab/EffectTypeEnum#relative_risk>,
        <https://w3id.org/biolink/vocab/EffectTypeEnum#root_mean_square_standardized_effect>,
        <https://w3id.org/biolink/vocab/EffectTypeEnum#spearmans_rho>,
        <https://w3id.org/biolink/vocab/EffectTypeEnum#standardized_mean_difference>,
        <https://w3id.org/biolink/vocab/EffectTypeEnum#strictly_standardized_mean_difference>,
        <https://w3id.org/biolink/vocab/EffectTypeEnum#wald_ratio>,
        <https://w3id.org/biolink/vocab/EffectTypeEnum#weighted_median> .

biolink:Gene a owl:Class ;
    rdfs:label "gene" ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:minCardinality 0 ;
            owl:onProperty biolink:xref ],
        [ a owl:Restriction ;
            owl:minCardinality 0 ;
            owl:onProperty biolink:symbol ],
        [ a owl:Restriction ;
            owl:onProperty linkml:mixins ;
            owl:someValuesFrom biolink:OntologyClass ],
        [ a owl:Restriction ;
            owl:onProperty linkml:mixins ;
            owl:someValuesFrom biolink:GenomicEntity ],
        [ a owl:Restriction ;
            owl:allValuesFrom xsd:anyURI ;
            owl:onProperty biolink:xref ],
        [ a owl:Restriction ;
            owl:onProperty linkml:mixins ;
            owl:someValuesFrom biolink:PhysicalEssence ],
        [ a owl:Restriction ;
            owl:onProperty linkml:mixins ;
            owl:someValuesFrom biolink:ChemicalEntityOrGeneOrGeneProduct ],
        [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:symbol ],
        [ a owl:Restriction ;
            owl:onProperty linkml:mixins ;
            owl:someValuesFrom biolink:GeneOrGeneProduct ],
        [ a owl:Restriction ;
            owl:onProperty linkml:mixins ;
            owl:someValuesFrom biolink:GeneOrGeneProductOrGeneFamily ],
        [ a owl:Restriction ;
            owl:allValuesFrom xsd:string ;
            owl:onProperty biolink:symbol ],
        biolink:BiologicalEntity ;
    skos:broadMatch <http://purl.obolibrary.org/obo/NCIT_C45822> ;
    skos:definition "A region (or regions) that includes all of the sequence elements necessary to encode a functional transcript. A gene locus may include regulatory regions, transcribed regions and/or other functional sequence regions." ;
    skos:exactMatch <http://purl.obolibrary.org/obo/SO_0000704>,
        SIO:010035,
        dcid:Gene,
        WIKIDATA:Q7187 ;
    skos:inScheme biolink: ;
    skos:narrowMatch bioschemas:gene .

biolink:id a owl:DatatypeProperty ;
    rdfs:label "id" ;
    rdfs:domain biolink:Entity ;
    skos:definition "A unique identifier for an entity. Must be either a CURIE shorthand for a URI or a complete URI" ;
    skos:exactMatch gff3:ID,
        gpi:DB_Object_ID,
        AGRKB:primaryId ;
    skos:inScheme biolink: .

biolink:OrganismTaxon a owl:Class ;
    rdfs:label "organism taxon" ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:minCardinality 0 ;
            owl:onProperty biolink:has_taxonomic_rank ],
        [ a owl:Restriction ;
            owl:allValuesFrom biolink:TaxonomicRank ;
            owl:onProperty biolink:has_taxonomic_rank ],
        [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:has_taxonomic_rank ],
        biolink:NamedThing ;
    skos:altLabel "taxon",
        "taxonomic classification" ;
    skos:definition "A classification of a set of organisms. Example instances: NCBITaxon:9606 (Homo sapiens), NCBITaxon:2 (Bacteria). Can also be used to represent strains or subspecies." ;
    skos:exactMatch STY:T001,
        bioschemas:Taxon,
        WIKIDATA:Q16521 ;
    skos:inScheme biolink: ;
    skos:narrowMatch dcid:BiologicalSpecies .

biolink:Publication a owl:Class ;
    rdfs:label "publication" ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:minCardinality 0 ;
            owl:onProperty biolink:name ],
        [ a owl:Restriction ;
            owl:allValuesFrom xsd:string ;
            owl:onProperty biolink:keywords ],
        [ a owl:Restriction ;
            owl:allValuesFrom xsd:string ;
            owl:onProperty biolink:publication_type ],
        [ a owl:Restriction ;
            owl:allValuesFrom xsd:string ;
            owl:onProperty biolink:pages ],
        [ a owl:Restriction ;
            owl:minCardinality 0 ;
            owl:onProperty biolink:pages ],
        [ a owl:Restriction ;
            owl:allValuesFrom xsd:anyURI ;
            owl:onProperty biolink:xref ],
        [ a owl:Restriction ;
            owl:allValuesFrom biolink:Study ;
            owl:onProperty biolink:has_studies ],
        [ a owl:Restriction ;
            owl:minCardinality 0 ;
            owl:onProperty biolink:summary ],
        [ a owl:Restriction ;
            owl:allValuesFrom xsd:string ;
            owl:onProperty biolink:summary ],
        [ a owl:Restriction ;
            owl:minCardinality 0 ;
            owl:onProperty biolink:mesh_terms ],
        [ a owl:Restriction ;
            owl:allValuesFrom biolink:Agent ;
            owl:onProperty biolink:authors ],
        [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:id ],
        [ a owl:Restriction ;
            owl:allValuesFrom xsd:anyURI ;
            owl:onProperty biolink:mesh_terms ],
        [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:name ],
        [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:summary ],
        [ a owl:Restriction ;
            owl:minCardinality 0 ;
            owl:onProperty biolink:xref ],
        [ a owl:Restriction ;
            owl:minCardinality 0 ;
            owl:onProperty biolink:authors ],
        [ a owl:Restriction ;
            owl:allValuesFrom xsd:string ;
            owl:onProperty biolink:name ],
        [ a owl:Restriction ;
            owl:minCardinality 1 ;
            owl:onProperty biolink:id ],
        [ a owl:Restriction ;
            owl:minCardinality 0 ;
            owl:onProperty biolink:keywords ],
        [ a owl:Restriction ;
            owl:allValuesFrom xsd:string ;
            owl:onProperty biolink:id ],
        [ a owl:Restriction ;
            owl:minCardinality 1 ;
            owl:onProperty biolink:publication_type ],
        [ a owl:Restriction ;
            owl:minCardinality 0 ;
            owl:onProperty biolink:has_studies ],
        biolink:InformationContentEntity ;
    skos:definition "Any ‘published’ piece of information. Publications are considered broadly to include any document or document part made available in print or on the web - which may include scientific journal issues, individual articles, and books - as well as things like pre-prints, white papers, patents, drug labels, web pages, protocol documents,  and even a part of a publication if of significant knowledge scope." ;
    skos:exactMatch IAO:0000311 ;
    skos:inScheme biolink: ;
    skos:narrowMatch STY:T170,
        IAO:0000013 .

biolink:BiologicalEntity a owl:Class ;
    rdfs:label "biological entity" ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:onProperty linkml:mixins ;
            owl:someValuesFrom biolink:ThingWithTaxon ],
        [ owl:unionOf ( biolink:BiologicalProcessOrActivity biolink:CodingSequence biolink:DiseaseOrPhenotypicFeature biolink:Exon biolink:Gene biolink:GeneFamily biolink:GeneticInheritance biolink:Genome biolink:Genotype biolink:Haplotype biolink:MacromolecularComplex biolink:NucleicAcidSequenceMotif biolink:NucleosomeModification biolink:OrganismalEntity biolink:Polypeptide biolink:PosttranslationalModification biolink:ProteinDomain biolink:ProteinFamily biolink:ReagentTargetedGene biolink:RegulatoryRegion biolink:SequenceVariant biolink:Transcript ) ],
        biolink:NamedThing ;
    skos:altLabel "bioentity" ;
    skos:definition "A heterogeneous substance that contains genomic material or is the product of a biological process." ;
    skos:inScheme biolink: ;
    skos:narrowMatch STY:T050,
        STY:T129,
        SIO:010046,
        WIKIDATA:Q28845870 .

biolink:SequenceVariant a owl:Class ;
    rdfs:label "sequence variant" ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:onProperty linkml:mixins ;
            owl:someValuesFrom biolink:OntologyClass ],
        [ a owl:Restriction ;
            owl:minCardinality 0 ;
            owl:onProperty biolink:hgvs_nomenclature ],
        [ a owl:Restriction ;
            owl:minCardinality 0 ;
            owl:onProperty biolink:has_biological_sequence ],
        [ a owl:Restriction ;
            owl:onProperty linkml:mixins ;
            owl:someValuesFrom biolink:PhysicalEssence ],
        [ a owl:Restriction ;
            owl:allValuesFrom biolink:Gene ;
            owl:onProperty biolink:has_gene ],
        [ a owl:Restriction ;
            owl:allValuesFrom xsd:string ;
            owl:onProperty biolink:hgvs_nomenclature ],
        [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:has_biological_sequence ],
        [ a owl:Restriction ;
            owl:minCardinality 0 ;
            owl:onProperty biolink:has_gene ],
        [ a owl:Restriction ;
            owl:allValuesFrom xsd:string ;
            owl:onProperty biolink:id ],
        [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:id ],
        [ a owl:Restriction ;
            owl:minCardinality 1 ;
            owl:onProperty biolink:id ],
        [ a owl:Restriction ;
            owl:allValuesFrom xsd:string ;
            owl:onProperty biolink:has_biological_sequence ],
        [ a owl:Restriction ;
            owl:onProperty linkml:mixins ;
            owl:someValuesFrom biolink:GenomicEntity ],
        biolink:BiologicalEntity ;
    skos:altLabel "allele" ;
    skos:closeMatch <http://purl.obolibrary.org/obo/GENO_0000002>,
        <http://purl.obolibrary.org/obo/SO_0001060>,
        SIO:010277,
        dcid:Allele,
        VMC:Allele ;
    skos:definition "A sequence_variant is a non exact copy of a sequence_feature or genome exhibiting one or more sequence_alteration." ;
    skos:exactMatch WIKIDATA:Q15304597 ;
    skos:inScheme biolink: ;
    skos:note "This class is for modeling the specific state at a locus. A single DBSNP rs ID could correspond to more than one sequence variants (e.g CIViC:1252 and CIViC:1253, two distinct BRCA2 alleles for rs28897743)" .

biolink:GenomicEntity a owl:Class ;
    rdfs:label "genomic entity" ;
    rdfs:subClassOf <https://w3id.org/linkml/ClassDefinition#Mixin> ;
    skos:definition "A generically dependent continuant that carries biological sequence that is part of or derived from a genome." ;
    skos:inScheme biolink: ;
    skos:narrowMatch STY:T028,
        <http://purl.obolibrary.org/obo/GENO_0000897> .

biolink:subject_direction_qualifier a owl:ObjectProperty ;
    rdfs:label "subject direction qualifier" ;
    rdfs:range biolink:DirectionQualifierEnum ;
    rdfs:subPropertyOf biolink:direction_qualifier ;
    skos:definition "Composes with the core concept (+ aspect if provided) to describe a change in its direction or degree. This qualifier qualifies the subject of an association (aka: statement)." ;
    skos:inScheme biolink: .

<https://w3id.org/biolink/vocab/CausalMechanismQualifierEnum#modulation> a owl:Class ;
    rdfs:label "modulation" ;
    rdfs:subClassOf biolink:CausalMechanismQualifierEnum,
        linkml:PermissibleValue ;
    skos:definition "A causal mechanism that effects the normal functioning of a protein in some way e.g., mixed agonist/antagonist or unclear whether action is positive or negative" .

<https://w3id.org/biolink/vocab/GeneOrGeneProductOrChemicalEntityAspectEnum#molecular_modification> a owl:Class ;
    rdfs:label "molecular_modification" ;
    rdfs:subClassOf biolink:GeneOrGeneProductOrChemicalEntityAspectEnum,
        linkml:PermissibleValue .

biolink:subject_form_or_variant_qualifier a owl:DatatypeProperty ;
    rdfs:label "subject form or variant qualifier" ;
    rdfs:subPropertyOf biolink:form_or_variant_qualifier ;
    skos:definition "A qualifier that composes with a core subject/object concept to define a specific type, variant, alternative version of this concept. The composed concept remains a subtype or instance of the core concept. For example, the qualifier ‘mutation’ combines with the core concept ‘Gene X’ to express the compose concept ‘a mutation of Gene X’.  This qualifier specifies a change in the subject of an association (aka: statement)." ;
    skos:inScheme biolink: .

biolink:ChemicalEntityOrGeneOrGeneProduct a owl:Class ;
    rdfs:label "chemical entity or gene or gene product" ;
    rdfs:subClassOf <https://w3id.org/linkml/ClassDefinition#Mixin> ;
    skos:definition "A union of chemical entities and children, and gene or gene product. This mixin is helpful to use when searching across chemical entities that must include genes and their children as chemical entities." ;
    skos:inScheme biolink: .

biolink:ChemicalOrDrugOrTreatment a owl:Class ;
    rdfs:label "chemical or drug or treatment" ;
    rdfs:subClassOf <https://w3id.org/linkml/ClassDefinition#Mixin> ;
    skos:definition "A mixin for entities that represent chemical substances, pharmacological agents, or therapeutic interventions." ;
    skos:inScheme biolink: .

biolink:DirectionQualifierEnum a owl:Class ;
    rdfs:label "DirectionQualifierEnum" ;
    rdfs:subClassOf linkml:EnumDefinition ;
    owl:unionOf ( <https://w3id.org/biolink/vocab/DirectionQualifierEnum#increased> <https://w3id.org/biolink/vocab/DirectionQualifierEnum#upregulated> <https://w3id.org/biolink/vocab/DirectionQualifierEnum#decreased> <https://w3id.org/biolink/vocab/DirectionQualifierEnum#downregulated> ) ;
    skos:definition "An enumeration of values that qualify a change or effect by its direction, i.e., whether the referenced quantity or activity is increased (including up-regulated) or decreased (including down-regulated)." ;
    skos:inScheme biolink: ;
    linkml:permissible_values <https://w3id.org/biolink/vocab/DirectionQualifierEnum#decreased>,
        <https://w3id.org/biolink/vocab/DirectionQualifierEnum#downregulated>,
        <https://w3id.org/biolink/vocab/DirectionQualifierEnum#increased>,
        <https://w3id.org/biolink/vocab/DirectionQualifierEnum#upregulated> .

biolink:AnatomicalEntity a owl:Class ;
    rdfs:label "anatomical entity" ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:onProperty linkml:mixins ;
            owl:someValuesFrom biolink:OntologyClass ],
        [ a owl:Restriction ;
            owl:onProperty linkml:mixins ;
            owl:someValuesFrom biolink:PhysicalEssence ],
        biolink:OrganismalEntity ;
    skos:definition "A part of a cellular organism at or above the granularity of a protein complex. This is a grouping class with three concrete subclasses that should be preferred when applicable: \"biolink:Cell\" for whole cells, \"biolink:CellularComponent\" for subcellular and intracellular structures (organelles, membranes, bacterial flagella, etc.), and \"biolink:GrossAnatomcialStructure\" for multicellular parts (tissues, organs, body parts). Excludes viral and other acellular biological entities." ;
    skos:exactMatch STY:T017,
        STY:T029,
        STY:T030,
        <http://purl.obolibrary.org/obo/CARO_0000000>,
        FMA:62955,
        <http://purl.obolibrary.org/obo/UBERON_0001062>,
        SIO:001262,
        UMLSSG:ANAT,
        WIKIDATA:Q4936952 ;
    skos:inScheme biolink: ;
    skos:narrowMatch STY:T031,
        <http://purl.obolibrary.org/obo/EMAPA_0>,
        <http://purl.obolibrary.org/obo/FBbt_10000000>,
        <http://purl.obolibrary.org/obo/GO_0110165>,
        <http://purl.obolibrary.org/obo/MA_0000001>,
        <http://purl.obolibrary.org/obo/NCIT_C12219>,
        WBbt:0000100,
        <http://purl.obolibrary.org/obo/XAO_0000000>,
        <http://purl.obolibrary.org/obo/ZFA_0100000> ;
    skos:relatedMatch SNOMEDCT:123037004 .

biolink:ChemicalEntity a owl:Class ;
    rdfs:label "chemical entity" ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:chembl_drug_warning ],
        [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:chembl_chirality ],
        [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:trade_name ],
        [ a owl:Restriction ;
            owl:minCardinality 0 ;
            owl:onProperty biolink:routes_of_delivery ],
        [ a owl:Restriction ;
            owl:allValuesFrom xsd:string ;
            owl:onProperty biolink:chembl_availability_type ],
        [ a owl:Restriction ;
            owl:allValuesFrom xsd:string ;
            owl:onProperty biolink:max_tolerated_dose ],
        [ a owl:Restriction ;
            owl:minCardinality 0 ;
            owl:onProperty biolink:chembl_natural_product ],
        [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:is_toxic ],
        [ a owl:Restriction ;
            owl:minCardinality 0 ;
            owl:onProperty biolink:has_chemical_role ],
        [ a owl:Restriction ;
            owl:allValuesFrom biolink:DrugAvailabilityEnum ;
            owl:onProperty biolink:available_from ],
        [ a owl:Restriction ;
            owl:minCardinality 0 ;
            owl:onProperty biolink:chembl_availability_type ],
        [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:max_tolerated_dose ],
        [ a owl:Restriction ;
            owl:allValuesFrom biolink:ChemicalRole ;
            owl:onProperty biolink:has_chemical_role ],
        [ a owl:Restriction ;
            owl:minCardinality 0 ;
            owl:onProperty biolink:chembl_chirality ],
        [ a owl:Restriction ;
            owl:allValuesFrom xsd:string ;
            owl:onProperty biolink:trade_name ],
        [ a owl:Restriction ;
            owl:allValuesFrom xsd:boolean ;
            owl:onProperty biolink:is_toxic ],
        [ a owl:Restriction ;
            owl:onProperty linkml:mixins ;
            owl:someValuesFrom biolink:ChemicalOrDrugOrTreatment ],
        [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:chembl_black_box_warning ],
        [ a owl:Restriction ;
            owl:minCardinality 0 ;
            owl:onProperty biolink:max_tolerated_dose ],
        [ a owl:Restriction ;
            owl:allValuesFrom xsd:boolean ;
            owl:onProperty biolink:chembl_natural_product ],
        [ a owl:Restriction ;
            owl:allValuesFrom xsd:string ;
            owl:onProperty biolink:chembl_black_box_warning ],
        [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:chembl_prodrug ],
        [ a owl:Restriction ;
            owl:allValuesFrom xsd:string ;
            owl:onProperty biolink:chembl_drug_warning ],
        [ a owl:Restriction ;
            owl:allValuesFrom xsd:string ;
            owl:onProperty biolink:chembl_chirality ],
        [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:chembl_natural_product ],
        [ a owl:Restriction ;
            owl:minCardinality 0 ;
            owl:onProperty biolink:trade_name ],
        [ a owl:Restriction ;
            owl:minCardinality 0 ;
            owl:onProperty biolink:chembl_prodrug ],
        [ a owl:Restriction ;
            owl:onProperty linkml:mixins ;
            owl:someValuesFrom biolink:ChemicalEntityOrProteinOrPolypeptide ],
        [ a owl:Restriction ;
            owl:allValuesFrom xsd:boolean ;
            owl:onProperty biolink:chembl_prodrug ],
        [ a owl:Restriction ;
            owl:minCardinality 0 ;
            owl:onProperty biolink:is_toxic ],
        [ a owl:Restriction ;
            owl:minCardinality 0 ;
            owl:onProperty biolink:available_from ],
        [ a owl:Restriction ;
            owl:onProperty linkml:mixins ;
            owl:someValuesFrom biolink:PhysicalEssence ],
        [ a owl:Restriction ;
            owl:onProperty linkml:mixins ;
            owl:someValuesFrom biolink:ChemicalEntityOrGeneOrGeneProduct ],
        [ a owl:Restriction ;
            owl:minCardinality 0 ;
            owl:onProperty biolink:chembl_black_box_warning ],
        [ a owl:Restriction ;
            owl:allValuesFrom biolink:DrugDeliveryEnum ;
            owl:onProperty biolink:routes_of_delivery ],
        [ a owl:Restriction ;
            owl:minCardinality 0 ;
            owl:onProperty biolink:chembl_drug_warning ],
        [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:chembl_availability_type ],
        biolink:NamedThing ;
    skos:broadMatch STY:T167 ;
    skos:definition "A chemical entity is a physical entity that pertains to chemistry or biochemistry." ;
    skos:exactMatch STY:T103,
        <http://purl.obolibrary.org/obo/CHEBI_24431>,
        SIO:010004,
        WIKIDATA:Q79529 ;
    skos:inScheme biolink: ;
    skos:narrowMatch STY:T123,
        STY:T131,
        WIKIDATA:Q43460564 .

biolink:species_context_qualifier a owl:ObjectProperty ;
    rdfs:label "species context qualifier" ;
    rdfs:range biolink:OrganismTaxon ;
    rdfs:subPropertyOf biolink:statement_qualifier ;
    skos:definition "A statement qualifier representing a taxonomic category of species in which a relationship expressed in an association took place." ;
    skos:editorialNote "Ontology CURIEs are expected as values here, the examples below are intended to help clarify the content of the CURIEs." ;
    skos:inScheme biolink: .

biolink:object_aspect_qualifier a owl:ObjectProperty ;
    rdfs:label "object aspect qualifier" ;
    rdfs:range biolink:GeneOrGeneProductOrChemicalEntityAspectEnum ;
    rdfs:subPropertyOf biolink:aspect_qualifier ;
    skos:definition "Composes with the core concept to describe new concepts of a different ontological type. e.g. a process in which the core concept participates, a function/activity/role held by the core concept, or a characteristic/quality that inheres in the core concept.  The purpose of the aspect slot is to indicate what aspect is being affected in an 'affects' association.  This qualifier specifies a change in the object of an association (aka: statement)." ;
    skos:inScheme biolink: .

biolink:subject_aspect_qualifier a owl:ObjectProperty ;
    rdfs:label "subject aspect qualifier" ;
    rdfs:range biolink:GeneOrGeneProductOrChemicalEntityAspectEnum ;
    rdfs:subPropertyOf biolink:aspect_qualifier ;
    skos:definition "Composes with the core concept to describe new concepts of a different ontological type. e.g. a process in which the core concept participates, a function/activity/role held by the core concept, or a characteristic/quality that inheres in the core concept.  The purpose of the aspect slot is to indicate what aspect is being affected in an 'affects' association.  This qualifier specifies a change in the subject of an association (aka: statement)." ;
    skos:inScheme biolink: .

biolink:GeneOrGeneProduct a owl:Class ;
    rdfs:label "gene or gene product" ;
    rdfs:subClassOf biolink:MacromolecularMachineMixin ;
    skos:closeMatch <http://identifiers.org/drugbank/target> ;
    skos:definition "A union of gene loci or gene products. Frequently an identifier for one will be used as proxy for another" ;
    skos:inScheme biolink: .

biolink:qualified_predicate a owl:DatatypeProperty ;
    rdfs:label "qualified predicate" ;
    rdfs:range xsd:anyURI ;
    rdfs:subPropertyOf biolink:qualifier ;
    skos:definition "Predicate to be used in an association when subject and object qualifiers are present and the full reading of the statement requires a qualification to the predicate in use in order to refine or increase the specificity of the full statement reading.  Has a value from the Biolink 'related_to' hierarchy, for example, biolink:related_to, biolink:causes, biolink:treats This qualifier holds a relationship to be used instead of that expressed by the primary predicate, in a ‘full statement’ reading of the association, where qualifier-based semantics are included. This is necessary only in cases where the primary predicate does not work in a full statement reading." ;
    skos:editorialNote "to express the statement that “Chemical X causes increased expression of Gene Y”, the core triple is read using the fields subject:ChemX, predicate:affects, object:GeneY . . . and the full statement is read using the fields subject:ChemX, qualified_predicate:causes, object:GeneY, object_aspect: expression, object_direction:increased. The predicate ‘affects’ is needed for the core triple reading, but does not make sense in the full statement reading  (because “Chemical X affects increased expression of Gene Y'' is not what we mean to say here: it causes increased expression of Gene Y)" ;
    skos:inScheme biolink: .

biolink:DiseaseOrPhenotypicFeature a owl:Class ;
    rdfs:label "disease or phenotypic feature" ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:allValuesFrom biolink:GeneticInheritance ;
            owl:onProperty biolink:inheritance ],
        [ a owl:Restriction ;
            owl:minCardinality 0 ;
            owl:onProperty biolink:inheritance ],
        [ a owl:Restriction ;
            owl:onProperty linkml:mixins ;
            owl:someValuesFrom biolink:OntologyClass ],
        [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:inheritance ],
        biolink:BiologicalEntity ;
    skos:altLabel "phenome" ;
    skos:definition "A disease or an individual phenotypic feature, grouped as a single class to accommodate source vocabularies and assertions that do not distinguish the two. Prefer the more specific subclasses disease or phenotypic feature when the distinction is known." ;
    skos:inScheme biolink: ;
    skos:relatedMatch STY:T033 .

biolink:object_direction_qualifier a owl:ObjectProperty ;
    rdfs:label "object direction qualifier" ;
    rdfs:range biolink:DirectionQualifierEnum ;
    rdfs:subPropertyOf biolink:direction_qualifier ;
    skos:definition "Composes with the core concept (+ aspect if provided) to describe a change in its direction or degree. This qualifier qualifies the object of an association (aka: statement)." ;
    skos:inScheme biolink: .

biolink:OntologyClass a owl:Class ;
    rdfs:label "ontology class" ;
    rdfs:seeAlso <https://github.com/biolink/biolink-model/issues/486> ;
    rdfs:subClassOf <https://w3id.org/linkml/ClassDefinition#Mixin> ;
    skos:definition "a concept or class in an ontology, vocabulary or thesaurus. Note that nodes in a biolink compatible KG can be considered both instances of biolink classes, and OWL classes in their own right. In general you should not need to use this class directly. Instead, use the appropriate biolink class. For example, for the GO concept of endocytosis (GO:0006897), use biolink:BiologicalProcess as the type." ;
    skos:exactMatch schema1:Class,
        owl:Class ;
    skos:inScheme biolink: ;
    skos:note "Note that formally this is a metaclass. Instances of this class are instances in the graph, but can be the object of 'type' edges. For example, if we had a node in the graph representing a specific brain of a specific patient (e.g brain001), this could have a category of bl:Sample, and by typed more specifically with an ontology class UBERON:nnn, which has as category bl:AnatomicalEntity",
        "This is modeled as a mixin. 'ontology class' should not be the primary type of a node in the KG. Instead you should use an informative bioloink category, such as AnatomicalEntity (for Uberon classes), ChemicalSubstance (for CHEBI or CHEMBL), etc" .

biolink:association_slot a owl:DatatypeProperty ;
    rdfs:label "association slot" ;
    rdfs:domain biolink:Association ;
    skos:altLabel "edge property",
        "edge qualifier",
        "node qualifier",
        "statement property",
        "statement qualifier" ;
    skos:definition "any slot that relates an association to another entity" ;
    skos:inScheme biolink: .

biolink:related_to_at_instance_level a owl:DatatypeProperty,
        owl:SymmetricProperty ;
    rdfs:label "related to at instance level" ;
    rdfs:subPropertyOf biolink:related_to ;
    skos:definition "Represents a relationship held between two instances of a data classes.  Much like an assertion component, in an ABox, these represent facts associated with the conceptual model." ;
    skos:inScheme biolink: ;
    biolink:canonical_predicate true .

biolink:GeneOrGeneProductOrChemicalEntityAspectEnum a owl:Class ;
    rdfs:label "GeneOrGeneProductOrChemicalEntityAspectEnum" ;
    rdfs:subClassOf linkml:EnumDefinition ;
    owl:unionOf ( <https://w3id.org/biolink/vocab/GeneOrGeneProductOrChemicalEntityAspectEnum#activity_or_abundance> <https://w3id.org/biolink/vocab/GeneOrGeneProductOrChemicalEntityAspectEnum#abundance> <https://w3id.org/biolink/vocab/GeneOrGeneProductOrChemicalEntityAspectEnum#activity> <https://w3id.org/biolink/vocab/GeneOrGeneProductOrChemicalEntityAspectEnum#expression> <https://w3id.org/biolink/vocab/GeneOrGeneProductOrChemicalEntityAspectEnum#synthesis> <https://w3id.org/biolink/vocab/GeneOrGeneProductOrChemicalEntityAspectEnum#degradation> <https://w3id.org/biolink/vocab/GeneOrGeneProductOrChemicalEntityAspectEnum#cleavage> <https://w3id.org/biolink/vocab/GeneOrGeneProductOrChemicalEntityAspectEnum#hydrolysis> <https://w3id.org/biolink/vocab/GeneOrGeneProductOrChemicalEntityAspectEnum#metabolic_processing> <https://w3id.org/biolink/vocab/GeneOrGeneProductOrChemicalEntityAspectEnum#mutation_rate> <https://w3id.org/biolink/vocab/GeneOrGeneProductOrChemicalEntityAspectEnum#stability> <https://w3id.org/biolink/vocab/GeneOrGeneProductOrChemicalEntityAspectEnum#folding> <https://w3id.org/biolink/vocab/GeneOrGeneProductOrChemicalEntityAspectEnum#localization> <https://w3id.org/biolink/vocab/GeneOrGeneProductOrChemicalEntityAspectEnum#transport> <https://w3id.org/biolink/vocab/GeneOrGeneProductOrChemicalEntityAspectEnum#absorption> <https://w3id.org/biolink/vocab/GeneOrGeneProductOrChemicalEntityAspectEnum#aggregation> <https://w3id.org/biolink/vocab/GeneOrGeneProductOrChemicalEntityAspectEnum#interaction> <https://w3id.org/biolink/vocab/GeneOrGeneProductOrChemicalEntityAspectEnum#release> <https://w3id.org/biolink/vocab/GeneOrGeneProductOrChemicalEntityAspectEnum#isomerization> <https://w3id.org/biolink/vocab/GeneOrGeneProductOrChemicalEntityAspectEnum#secretion> <https://w3id.org/biolink/vocab/GeneOrGeneProductOrChemicalEntityAspectEnum#uptake> <https://w3id.org/biolink/vocab/GeneOrGeneProductOrChemicalEntityAspectEnum#splicing> <https://w3id.org/biolink/vocab/GeneOrGeneProductOrChemicalEntityAspectEnum#molecular_interaction> <https://w3id.org/biolink/vocab/GeneOrGeneProductOrChemicalEntityAspectEnum#guanyl_nucleotide_exchange> <https://w3id.org/biolink/vocab/GeneOrGeneProductOrChemicalEntityAspectEnum#adenyl_nucleotide_exchange> <https://w3id.org/biolink/vocab/GeneOrGeneProductOrChemicalEntityAspectEnum#molecular_modification> <https://w3id.org/biolink/vocab/GeneOrGeneProductOrChemicalEntityAspectEnum#acetylation> <https://w3id.org/biolink/vocab/GeneOrGeneProductOrChemicalEntityAspectEnum#acylation> <https://w3id.org/biolink/vocab/GeneOrGeneProductOrChemicalEntityAspectEnum#alkylation> <https://w3id.org/biolink/vocab/GeneOrGeneProductOrChemicalEntityAspectEnum#amination> <https://w3id.org/biolink/vocab/GeneOrGeneProductOrChemicalEntityAspectEnum#carbamoylation> <https://w3id.org/biolink/vocab/GeneOrGeneProductOrChemicalEntityAspectEnum#ethylation> <https://w3id.org/biolink/vocab/GeneOrGeneProductOrChemicalEntityAspectEnum#glutathionylation> <https://w3id.org/biolink/vocab/GeneOrGeneProductOrChemicalEntityAspectEnum#glycation> <https://w3id.org/biolink/vocab/GeneOrGeneProductOrChemicalEntityAspectEnum#glycosylation> <https://w3id.org/biolink/vocab/GeneOrGeneProductOrChemicalEntityAspectEnum#glucuronidation> <https://w3id.org/biolink/vocab/GeneOrGeneProductOrChemicalEntityAspectEnum#n_linked_glycosylation> <https://w3id.org/biolink/vocab/GeneOrGeneProductOrChemicalEntityAspectEnum#o_linked_glycosylation> <https://w3id.org/biolink/vocab/GeneOrGeneProductOrChemicalEntityAspectEnum#hydroxylation> <https://w3id.org/biolink/vocab/GeneOrGeneProductOrChemicalEntityAspectEnum#lipidation> <https://w3id.org/biolink/vocab/GeneOrGeneProductOrChemicalEntityAspectEnum#farnesylation> <https://w3id.org/biolink/vocab/GeneOrGeneProductOrChemicalEntityAspectEnum#geranoylation> <https://w3id.org/biolink/vocab/GeneOrGeneProductOrChemicalEntityAspectEnum#myristoylation> <https://w3id.org/biolink/vocab/GeneOrGeneProductOrChemicalEntityAspectEnum#palmitoylation> <https://w3id.org/biolink/vocab/GeneOrGeneProductOrChemicalEntityAspectEnum#prenylation> <https://w3id.org/biolink/vocab/GeneOrGeneProductOrChemicalEntityAspectEnum#methylation> <https://w3id.org/biolink/vocab/GeneOrGeneProductOrChemicalEntityAspectEnum#nitrosation> <https://w3id.org/biolink/vocab/GeneOrGeneProductOrChemicalEntityAspectEnum#nucleotidylation> <https://w3id.org/biolink/vocab/GeneOrGeneProductOrChemicalEntityAspectEnum#phosphorylation> <https://w3id.org/biolink/vocab/GeneOrGeneProductOrChemicalEntityAspectEnum#ribosylation> <https://w3id.org/biolink/vocab/GeneOrGeneProductOrChemicalEntityAspectEnum#ADP-ribosylation> <https://w3id.org/biolink/vocab/GeneOrGeneProductOrChemicalEntityAspectEnum#sulfation> <https://w3id.org/biolink/vocab/GeneOrGeneProductOrChemicalEntityAspectEnum#sumoylation> <https://w3id.org/biolink/vocab/GeneOrGeneProductOrChemicalEntityAspectEnum#ubiquitination> <https://w3id.org/biolink/vocab/GeneOrGeneProductOrChemicalEntityAspectEnum#oxidation> <https://w3id.org/biolink/vocab/GeneOrGeneProductOrChemicalEntityAspectEnum#reduction> <https://w3id.org/biolink/vocab/GeneOrGeneProductOrChemicalEntityAspectEnum#carboxylation> ) ;
    skos:definition "An enumeration used as a qualifier to indicate the specific aspect of a gene, gene product, or chemical entity that is affected or measured in an association. Values cover activity and abundance (expression, synthesis, degradation, stability, localization, transport), molecular interactions, and a wide range of molecular modifications such as phosphorylation, methylation, acetylation, ubiquitination, and other post-translational or chemical modifications." ;
    skos:inScheme biolink: ;
    linkml:permissible_values <https://w3id.org/biolink/vocab/GeneOrGeneProductOrChemicalEntityAspectEnum#ADP-ribosylation>,
        <https://w3id.org/biolink/vocab/GeneOrGeneProductOrChemicalEntityAspectEnum#absorption>,
        <https://w3id.org/biolink/vocab/GeneOrGeneProductOrChemicalEntityAspectEnum#abundance>,
        <https://w3id.org/biolink/vocab/GeneOrGeneProductOrChemicalEntityAspectEnum#acetylation>,
        <https://w3id.org/biolink/vocab/GeneOrGeneProductOrChemicalEntityAspectEnum#activity>,
        <https://w3id.org/biolink/vocab/GeneOrGeneProductOrChemicalEntityAspectEnum#activity_or_abundance>,
        <https://w3id.org/biolink/vocab/GeneOrGeneProductOrChemicalEntityAspectEnum#acylation>,
        <https://w3id.org/biolink/vocab/GeneOrGeneProductOrChemicalEntityAspectEnum#adenyl_nucleotide_exchange>,
        <https://w3id.org/biolink/vocab/GeneOrGeneProductOrChemicalEntityAspectEnum#aggregation>,
        <https://w3id.org/biolink/vocab/GeneOrGeneProductOrChemicalEntityAspectEnum#alkylation>,
        <https://w3id.org/biolink/vocab/GeneOrGeneProductOrChemicalEntityAspectEnum#amination>,
        <https://w3id.org/biolink/vocab/GeneOrGeneProductOrChemicalEntityAspectEnum#carbamoylation>,
        <https://w3id.org/biolink/vocab/GeneOrGeneProductOrChemicalEntityAspectEnum#carboxylation>,
        <https://w3id.org/biolink/vocab/GeneOrGeneProductOrChemicalEntityAspectEnum#cleavage>,
        <https://w3id.org/biolink/vocab/GeneOrGeneProductOrChemicalEntityAspectEnum#degradation>,
        <https://w3id.org/biolink/vocab/GeneOrGeneProductOrChemicalEntityAspectEnum#ethylation>,
        <https://w3id.org/biolink/vocab/GeneOrGeneProductOrChemicalEntityAspectEnum#expression>,
        <https://w3id.org/biolink/vocab/GeneOrGeneProductOrChemicalEntityAspectEnum#farnesylation>,
        <https://w3id.org/biolink/vocab/GeneOrGeneProductOrChemicalEntityAspectEnum#folding>,
        <https://w3id.org/biolink/vocab/GeneOrGeneProductOrChemicalEntityAspectEnum#geranoylation>,
        <https://w3id.org/biolink/vocab/GeneOrGeneProductOrChemicalEntityAspectEnum#glucuronidation>,
        <https://w3id.org/biolink/vocab/GeneOrGeneProductOrChemicalEntityAspectEnum#glutathionylation>,
        <https://w3id.org/biolink/vocab/GeneOrGeneProductOrChemicalEntityAspectEnum#glycation>,
        <https://w3id.org/biolink/vocab/GeneOrGeneProductOrChemicalEntityAspectEnum#glycosylation>,
        <https://w3id.org/biolink/vocab/GeneOrGeneProductOrChemicalEntityAspectEnum#guanyl_nucleotide_exchange>,
        <https://w3id.org/biolink/vocab/GeneOrGeneProductOrChemicalEntityAspectEnum#hydrolysis>,
        <https://w3id.org/biolink/vocab/GeneOrGeneProductOrChemicalEntityAspectEnum#hydroxylation>,
        <https://w3id.org/biolink/vocab/GeneOrGeneProductOrChemicalEntityAspectEnum#interaction>,
        <https://w3id.org/biolink/vocab/GeneOrGeneProductOrChemicalEntityAspectEnum#isomerization>,
        <https://w3id.org/biolink/vocab/GeneOrGeneProductOrChemicalEntityAspectEnum#lipidation>,
        <https://w3id.org/biolink/vocab/GeneOrGeneProductOrChemicalEntityAspectEnum#localization>,
        <https://w3id.org/biolink/vocab/GeneOrGeneProductOrChemicalEntityAspectEnum#metabolic_processing>,
        <https://w3id.org/biolink/vocab/GeneOrGeneProductOrChemicalEntityAspectEnum#methylation>,
        <https://w3id.org/biolink/vocab/GeneOrGeneProductOrChemicalEntityAspectEnum#molecular_interaction>,
        <https://w3id.org/biolink/vocab/GeneOrGeneProductOrChemicalEntityAspectEnum#molecular_modification>,
        <https://w3id.org/biolink/vocab/GeneOrGeneProductOrChemicalEntityAspectEnum#mutation_rate>,
        <https://w3id.org/biolink/vocab/GeneOrGeneProductOrChemicalEntityAspectEnum#myristoylation>,
        <https://w3id.org/biolink/vocab/GeneOrGeneProductOrChemicalEntityAspectEnum#n_linked_glycosylation>,
        <https://w3id.org/biolink/vocab/GeneOrGeneProductOrChemicalEntityAspectEnum#nitrosation>,
        <https://w3id.org/biolink/vocab/GeneOrGeneProductOrChemicalEntityAspectEnum#nucleotidylation>,
        <https://w3id.org/biolink/vocab/GeneOrGeneProductOrChemicalEntityAspectEnum#o_linked_glycosylation>,
        <https://w3id.org/biolink/vocab/GeneOrGeneProductOrChemicalEntityAspectEnum#oxidation>,
        <https://w3id.org/biolink/vocab/GeneOrGeneProductOrChemicalEntityAspectEnum#palmitoylation>,
        <https://w3id.org/biolink/vocab/GeneOrGeneProductOrChemicalEntityAspectEnum#phosphorylation>,
        <https://w3id.org/biolink/vocab/GeneOrGeneProductOrChemicalEntityAspectEnum#prenylation>,
        <https://w3id.org/biolink/vocab/GeneOrGeneProductOrChemicalEntityAspectEnum#reduction>,
        <https://w3id.org/biolink/vocab/GeneOrGeneProductOrChemicalEntityAspectEnum#release>,
        <https://w3id.org/biolink/vocab/GeneOrGeneProductOrChemicalEntityAspectEnum#ribosylation>,
        <https://w3id.org/biolink/vocab/GeneOrGeneProductOrChemicalEntityAspectEnum#secretion>,
        <https://w3id.org/biolink/vocab/GeneOrGeneProductOrChemicalEntityAspectEnum#splicing>,
        <https://w3id.org/biolink/vocab/GeneOrGeneProductOrChemicalEntityAspectEnum#stability>,
        <https://w3id.org/biolink/vocab/GeneOrGeneProductOrChemicalEntityAspectEnum#sulfation>,
        <https://w3id.org/biolink/vocab/GeneOrGeneProductOrChemicalEntityAspectEnum#sumoylation>,
        <https://w3id.org/biolink/vocab/GeneOrGeneProductOrChemicalEntityAspectEnum#synthesis>,
        <https://w3id.org/biolink/vocab/GeneOrGeneProductOrChemicalEntityAspectEnum#transport>,
        <https://w3id.org/biolink/vocab/GeneOrGeneProductOrChemicalEntityAspectEnum#ubiquitination>,
        <https://w3id.org/biolink/vocab/GeneOrGeneProductOrChemicalEntityAspectEnum#uptake> .

biolink:NamedThing a owl:Class ;
    rdfs:label "named thing" ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:allValuesFrom xsd:float ;
            owl:onProperty biolink:information_content ],
        [ a owl:Restriction ;
            owl:allValuesFrom xsd:string ;
            owl:onProperty biolink:broad_synonym ],
        [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:broad_synonym ],
        [ a owl:Restriction ;
            owl:allValuesFrom xsd:string ;
            owl:onProperty biolink:exact_synonym ],
        [ a owl:Restriction ;
            owl:allValuesFrom xsd:string ;
            owl:onProperty biolink:full_name ],
        [ a owl:Restriction ;
            owl:minCardinality 0 ;
            owl:onProperty biolink:equivalent_identifiers ],
        [ a owl:Restriction ;
            owl:allValuesFrom xsd:anyURI ;
            owl:onProperty biolink:xref ],
        [ a owl:Restriction ;
            owl:minCardinality 0 ;
            owl:onProperty biolink:information_content ],
        [ a owl:Restriction ;
            owl:minCardinality 0 ;
            owl:onProperty biolink:related_synonym ],
        [ a owl:Restriction ;
            owl:minCardinality 0 ;
            owl:onProperty biolink:broad_synonym ],
        [ a owl:Restriction ;
            owl:minCardinality 0 ;
            owl:onProperty biolink:synonym ],
        [ a owl:Restriction ;
            owl:allValuesFrom xsd:string ;
            owl:onProperty biolink:provided_by ],
        [ a owl:Restriction ;
            owl:minCardinality 1 ;
            owl:onProperty biolink:category ],
        [ a owl:Restriction ;
            owl:minCardinality 0 ;
            owl:onProperty biolink:exact_synonym ],
        [ a owl:Restriction ;
            owl:allValuesFrom xsd:string ;
            owl:onProperty biolink:related_synonym ],
        [ a owl:Restriction ;
            owl:allValuesFrom xsd:string ;
            owl:onProperty biolink:category ],
        [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:taxon ],
        [ a owl:Restriction ;
            owl:allValuesFrom xsd:string ;
            owl:onProperty biolink:synonym ],
        [ a owl:Restriction ;
            owl:minCardinality 0 ;
            owl:onProperty biolink:xref ],
        [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:narrow_synonym ],
        [ a owl:Restriction ;
            owl:allValuesFrom xsd:string ;
            owl:onProperty biolink:narrow_synonym ],
        [ a owl:Restriction ;
            owl:minCardinality 0 ;
            owl:onProperty biolink:provided_by ],
        [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:full_name ],
        [ a owl:Restriction ;
            owl:allValuesFrom xsd:anyURI ;
            owl:onProperty biolink:taxon ],
        [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:related_synonym ],
        [ a owl:Restriction ;
            owl:allValuesFrom xsd:anyURI ;
            owl:onProperty biolink:equivalent_identifiers ],
        [ a owl:Restriction ;
            owl:minCardinality 0 ;
            owl:onProperty biolink:full_name ],
        [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:information_content ],
        [ a owl:Restriction ;
            owl:minCardinality 0 ;
            owl:onProperty biolink:taxon ],
        [ a owl:Restriction ;
            owl:minCardinality 0 ;
            owl:onProperty biolink:narrow_synonym ],
        [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:exact_synonym ],
        biolink:Entity ;
    skos:definition "a databased entity or concept/class" ;
    skos:exactMatch STY:T071,
        <http://purl.obolibrary.org/obo/BFO_0000001>,
        dcid:Thing,
        UMLSSG:OBJC,
        WIKIDATA:Q35120 ;
    skos:inScheme biolink: .

biolink:Association a owl:Class ;
    rdfs:label "association" ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:original_subject ],
        [ a owl:Restriction ;
            owl:allValuesFrom xsd:anyURI ;
            owl:onProperty biolink:original_predicate ],
        [ a owl:Restriction ;
            owl:minCardinality 0 ;
            owl:onProperty biolink:object_category_closure ],
        [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:stringdb_experimental_score ],
        [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:agent_type ],
        [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:subject_category ],
        [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:predicate ],
        [ a owl:Restriction ;
            owl:minCardinality 0 ;
            owl:onProperty biolink:type ],
        [ a owl:Restriction ;
            owl:minCardinality 0 ;
            owl:onProperty biolink:semmed_agreement_count ],
        [ a owl:Restriction ;
            owl:allValuesFrom biolink:OntologyClass ;
            owl:onProperty biolink:object_category_closure ],
        [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:object_namespace ],
        [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:object ],
        [ a owl:Restriction ;
            owl:allValuesFrom biolink:EffectTypeEnum ;
            owl:onProperty biolink:effect_type ],
        [ a owl:Restriction ;
            owl:allValuesFrom biolink:Study ;
            owl:onProperty biolink:has_supporting_studies ],
        [ a owl:Restriction ;
            owl:minCardinality 0 ;
            owl:onProperty biolink:has_confidence_score ],
        [ a owl:Restriction ;
            owl:minCardinality 0 ;
            owl:onProperty biolink:sources ],
        [ a owl:Restriction ;
            owl:minCardinality 0 ;
            owl:onProperty biolink:update_date ],
        [ a owl:Restriction ;
            owl:minCardinality 0 ;
            owl:onProperty biolink:subject_namespace ],
        [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:semmed_agreement_count ],
        [ a owl:Restriction ;
            owl:minCardinality 1 ;
            owl:onProperty biolink:object ],
        [ a owl:Restriction ;
            owl:minCardinality 0 ;
            owl:onProperty biolink:effect_size ],
        [ a owl:Restriction ;
            owl:allValuesFrom xsd:string ;
            owl:onProperty biolink:type ],
        [ a owl:Restriction ;
            owl:minCardinality 0 ;
            owl:onProperty biolink:evidence_count ],
        [ a owl:Restriction ;
            owl:allValuesFrom xsd:string ;
            owl:onProperty biolink:original_subject ],
        [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:has_confidence_score ],
        [ a owl:Restriction ;
            owl:minCardinality 0 ;
            owl:onProperty biolink:supporting_text ],
        [ a owl:Restriction ;
            owl:minCardinality 0 ;
            owl:onProperty biolink:subject_category ],
        [ a owl:Restriction ;
            owl:allValuesFrom biolink:OntologyClass ;
            owl:onProperty biolink:qualifiers ],
        [ a owl:Restriction ;
            owl:minCardinality 1 ;
            owl:onProperty biolink:agent_type ],
        [ a owl:Restriction ;
            owl:allValuesFrom xsd:integer ;
            owl:onProperty biolink:semmed_agreement_count ],
        [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:species_context_qualifier ],
        [ a owl:Restriction ;
            owl:minCardinality 0 ;
            owl:onProperty biolink:negated ],
        [ a owl:Restriction ;
            owl:minCardinality 0 ;
            owl:onProperty biolink:has_evidence_of_type ],
        [ a owl:Restriction ;
            owl:allValuesFrom xsd:float ;
            owl:onProperty biolink:stringdb_coexpression_score ],
        [ a owl:Restriction ;
            owl:allValuesFrom xsd:string ;
            owl:onProperty biolink:timepoint ],
        [ a owl:Restriction ;
            owl:minCardinality 0 ;
            owl:onProperty biolink:object_feature_name ],
        [ a owl:Restriction ;
            owl:minCardinality 1 ;
            owl:onProperty biolink:subject ],
        [ a owl:Restriction ;
            owl:minCardinality 0 ;
            owl:onProperty biolink:stringdb_coexpression_score ],
        [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:qualifier ],
        [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:association_basis_qualifier ],
        [ a owl:Restriction ;
            owl:allValuesFrom xsd:float ;
            owl:onProperty biolink:p_value ],
        [ a owl:Restriction ;
            owl:allValuesFrom xsd:string ;
            owl:onProperty biolink:object_closure ],
        [ a owl:Restriction ;
            owl:minCardinality 0 ;
            owl:onProperty biolink:category ],
        [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:adjusted_p_value ],
        [ a owl:Restriction ;
            owl:allValuesFrom biolink:EvidenceType ;
            owl:onProperty biolink:has_evidence_of_type ],
        [ a owl:Restriction ;
            owl:allValuesFrom xsd:string ;
            owl:onProperty biolink:primary_knowledge_source ],
        [ a owl:Restriction ;
            owl:allValuesFrom xsd:string ;
            owl:onProperty biolink:subject_closure ],
        [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:statistical_significance_qualifier ],
        [ a owl:Restriction ;
            owl:minCardinality 1 ;
            owl:onProperty biolink:predicate ],
        [ a owl:Restriction ;
            owl:allValuesFrom biolink:OntologyClass ;
            owl:onProperty biolink:object_category ],
        [ a owl:Restriction ;
            owl:allValuesFrom xsd:string ;
            owl:onProperty biolink:original_object ],
        [ a owl:Restriction ;
            owl:minCardinality 0 ;
            owl:onProperty biolink:object_category ],
        [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:stringdb_coexpression_score ],
        [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:stringdb_combined_score ],
        [ a owl:Restriction ;
            owl:allValuesFrom biolink:OrganismTaxon ;
            owl:onProperty biolink:species_context_qualifier ],
        [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:subject_namespace ],
        [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:update_date ],
        [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:effect_size ],
        [ a owl:Restriction ;
            owl:allValuesFrom biolink:RetrievalSource ;
            owl:onProperty biolink:sources ],
        [ a owl:Restriction ;
            owl:allValuesFrom biolink:RetrievalSource ;
            owl:onProperty biolink:retrieval_source_ids ],
        [ a owl:Restriction ;
            owl:allValuesFrom xsd:anyURI ;
            owl:onProperty biolink:predicate ],
        [ a owl:Restriction ;
            owl:minCardinality 0 ;
            owl:onProperty biolink:effect_type ],
        [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:knowledge_level ],
        [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:evidence_count ],
        [ a owl:Restriction ;
            owl:allValuesFrom xsd:date ;
            owl:onProperty biolink:update_date ],
        [ a owl:Restriction ;
            owl:minCardinality 0 ;
            owl:onProperty biolink:qualifiers ],
        [ a owl:Restriction ;
            owl:allValuesFrom biolink:AgentTypeEnum ;
            owl:onProperty biolink:agent_type ],
        [ a owl:Restriction ;
            owl:allValuesFrom xsd:string ;
            owl:onProperty biolink:object_feature_name ],
        [ a owl:Restriction ;
            owl:allValuesFrom biolink:InformationContentEntity ;
            owl:onProperty biolink:has_evidence ],
        [ a owl:Restriction ;
            owl:minCardinality 0 ;
            owl:onProperty biolink:aggregator_knowledge_source ],
        [ a owl:Restriction ;
            owl:minCardinality 0 ;
            owl:onProperty biolink:original_subject ],
        [ a owl:Restriction ;
            owl:allValuesFrom biolink:OntologyClass ;
            owl:onProperty biolink:subject_category_closure ],
        [ a owl:Restriction ;
            owl:minCardinality 0 ;
            owl:onProperty biolink:subject_label_closure ],
        [ a owl:Restriction ;
            owl:allValuesFrom xsd:boolean ;
            owl:onProperty biolink:negated ],
        [ a owl:Restriction ;
            owl:allValuesFrom xsd:integer ;
            owl:onProperty biolink:evidence_count ],
        [ a owl:Restriction ;
            owl:allValuesFrom biolink:OntologyClass ;
            owl:onProperty biolink:subject_category ],
        [ a owl:Restriction ;
            owl:minCardinality 0 ;
            owl:onProperty biolink:adjusted_p_value ],
        [ a owl:Restriction ;
            owl:allValuesFrom biolink:StatisticalSignificanceQualifierEnum ;
            owl:onProperty biolink:statistical_significance_qualifier ],
        [ a owl:Restriction ;
            owl:allValuesFrom biolink:NamedThing ;
            owl:onProperty biolink:object ],
        [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:original_object ],
        [ a owl:Restriction ;
            owl:minCardinality 0 ;
            owl:onProperty biolink:elevate_to_prediction ],
        [ a owl:Restriction ;
            owl:allValuesFrom xsd:float ;
            owl:onProperty biolink:adjusted_p_value ],
        [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:subject ],
        [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:object_feature_name ],
        [ a owl:Restriction ;
            owl:minCardinality 0 ;
            owl:onProperty biolink:stringdb_experimental_score ],
        [ a owl:Restriction ;
            owl:allValuesFrom xsd:string ;
            owl:onProperty biolink:subject_feature_name ],
        [ a owl:Restriction ;
            owl:minCardinality 0 ;
            owl:onProperty biolink:species_context_qualifier ],
        [ a owl:Restriction ;
            owl:minCardinality 0 ;
            owl:onProperty biolink:statistical_significance_qualifier ],
        [ a owl:Restriction ;
            owl:allValuesFrom xsd:float ;
            owl:onProperty biolink:stringdb_experimental_score ],
        [ a owl:Restriction ;
            owl:minCardinality 1 ;
            owl:onProperty biolink:knowledge_level ],
        [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:subject_feature_name ],
        [ a owl:Restriction ;
            owl:minCardinality 0 ;
            owl:onProperty biolink:publications ],
        [ a owl:Restriction ;
            owl:minCardinality 0 ;
            owl:onProperty biolink:subject_category_closure ],
        [ a owl:Restriction ;
            owl:allValuesFrom biolink:NamedThing ;
            owl:onProperty biolink:subject ],
        [ a owl:Restriction ;
            owl:minCardinality 0 ;
            owl:onProperty biolink:object_label_closure ],
        [ a owl:Restriction ;
            owl:minCardinality 0 ;
            owl:onProperty biolink:has_evidence ],
        [ a owl:Restriction ;
            owl:minCardinality 0 ;
            owl:onProperty biolink:knowledge_source ],
        [ a owl:Restriction ;
            owl:allValuesFrom biolink:KnowledgeLevelEnum ;
            owl:onProperty biolink:knowledge_level ],
        [ a owl:Restriction ;
            owl:allValuesFrom xsd:string ;
            owl:onProperty biolink:subject_namespace ],
        [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:original_predicate ],
        [ a owl:Restriction ;
            owl:minCardinality 0 ;
            owl:onProperty biolink:association_basis_qualifier ],
        [ a owl:Restriction ;
            owl:allValuesFrom xsd:float ;
            owl:onProperty biolink:effect_size ],
        [ a owl:Restriction ;
            owl:minCardinality 0 ;
            owl:onProperty biolink:original_object ],
        [ a owl:Restriction ;
            owl:minCardinality 0 ;
            owl:onProperty biolink:has_supporting_studies ],
        [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:knowledge_source ],
        [ a owl:Restriction ;
            owl:allValuesFrom xsd:anyURI ;
            owl:onProperty biolink:category ],
        [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:primary_knowledge_source ],
        [ a owl:Restriction ;
            owl:allValuesFrom biolink:AssociationBasisEnum ;
            owl:onProperty biolink:association_basis_qualifier ],
        [ a owl:Restriction ;
            owl:minCardinality 0 ;
            owl:onProperty biolink:retrieval_source_ids ],
        [ a owl:Restriction ;
            owl:minCardinality 0 ;
            owl:onProperty biolink:object_closure ],
        [ a owl:Restriction ;
            owl:allValuesFrom biolink:Publication ;
            owl:onProperty biolink:publications ],
        [ a owl:Restriction ;
            owl:minCardinality 0 ;
            owl:onProperty biolink:qualifier ],
        [ a owl:Restriction ;
            owl:allValuesFrom xsd:string ;
            owl:onProperty biolink:supporting_text ],
        [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:effect_type ],
        [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:timepoint ],
        [ a owl:Restriction ;
            owl:minCardinality 0 ;
            owl:onProperty biolink:timepoint ],
        [ a owl:Restriction ;
            owl:allValuesFrom xsd:string ;
            owl:onProperty biolink:object_namespace ],
        [ a owl:Restriction ;
            owl:allValuesFrom xsd:float ;
            owl:onProperty biolink:has_confidence_score ],
        [ a owl:Restriction ;
            owl:allValuesFrom xsd:string ;
            owl:onProperty biolink:object_label_closure ],
        [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:negated ],
        [ a owl:Restriction ;
            owl:allValuesFrom xsd:boolean ;
            owl:onProperty biolink:elevate_to_prediction ],
        [ a owl:Restriction ;
            owl:minCardinality 0 ;
            owl:onProperty biolink:stringdb_combined_score ],
        [ a owl:Restriction ;
            owl:minCardinality 0 ;
            owl:onProperty biolink:subject_feature_name ],
        [ a owl:Restriction ;
            owl:minCardinality 0 ;
            owl:onProperty biolink:subject_closure ],
        [ a owl:Restriction ;
            owl:allValuesFrom xsd:float ;
            owl:onProperty biolink:stringdb_combined_score ],
        [ a owl:Restriction ;
            owl:allValuesFrom xsd:string ;
            owl:onProperty biolink:qualifier ],
        [ a owl:Restriction ;
            owl:allValuesFrom xsd:string ;
            owl:onProperty biolink:knowledge_source ],
        [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:object_category ],
        [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:elevate_to_prediction ],
        [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:p_value ],
        [ a owl:Restriction ;
            owl:minCardinality 0 ;
            owl:onProperty biolink:p_value ],
        [ a owl:Restriction ;
            owl:allValuesFrom xsd:string ;
            owl:onProperty biolink:aggregator_knowledge_source ],
        [ a owl:Restriction ;
            owl:minCardinality 0 ;
            owl:onProperty biolink:original_predicate ],
        [ a owl:Restriction ;
            owl:allValuesFrom xsd:string ;
            owl:onProperty biolink:subject_label_closure ],
        [ a owl:Restriction ;
            owl:minCardinality 0 ;
            owl:onProperty biolink:primary_knowledge_source ],
        [ a owl:Restriction ;
            owl:minCardinality 0 ;
            owl:onProperty biolink:object_namespace ],
        biolink:Entity ;
    skos:definition "A typed association between two entities, supported by evidence" ;
    skos:exactMatch OBAN:association,
        rdf:Statement,
        owl:Axiom ;
    skos:inScheme biolink: ;
    skos:note "This is roughly the model used by biolink and ontobio at the moment" .

biolink:CausalMechanismQualifierEnum a owl:Class ;
    rdfs:label "CausalMechanismQualifierEnum" ;
    rdfs:subClassOf linkml:EnumDefinition ;
    owl:unionOf ( <https://w3id.org/biolink/vocab/CausalMechanismQualifierEnum#modulation> <https://w3id.org/biolink/vocab/CausalMechanismQualifierEnum#allosteric_modulation> <https://w3id.org/biolink/vocab/CausalMechanismQualifierEnum#mixed_allosteric_modulation> <https://w3id.org/biolink/vocab/CausalMechanismQualifierEnum#biphasic_allosteric_modulation> <https://w3id.org/biolink/vocab/CausalMechanismQualifierEnum#mixed_agonism> <https://w3id.org/biolink/vocab/CausalMechanismQualifierEnum#positive_modulation> <https://w3id.org/biolink/vocab/CausalMechanismQualifierEnum#potentiation> <https://w3id.org/biolink/vocab/CausalMechanismQualifierEnum#induction> <https://w3id.org/biolink/vocab/CausalMechanismQualifierEnum#cofactor> <https://w3id.org/biolink/vocab/CausalMechanismQualifierEnum#activation> <https://w3id.org/biolink/vocab/CausalMechanismQualifierEnum#positive_allosteric_modulation> <https://w3id.org/biolink/vocab/CausalMechanismQualifierEnum#agonism> <https://w3id.org/biolink/vocab/CausalMechanismQualifierEnum#partial_agonism> <https://w3id.org/biolink/vocab/CausalMechanismQualifierEnum#biased_agonism> <https://w3id.org/biolink/vocab/CausalMechanismQualifierEnum#antibody_agonism> <https://w3id.org/biolink/vocab/CausalMechanismQualifierEnum#molecular_channel_opening> <https://w3id.org/biolink/vocab/CausalMechanismQualifierEnum#stimulation> <https://w3id.org/biolink/vocab/CausalMechanismQualifierEnum#guanyl_nucleotide_exchange> <https://w3id.org/biolink/vocab/CausalMechanismQualifierEnum#negative_modulation> <https://w3id.org/biolink/vocab/CausalMechanismQualifierEnum#negative_gene_editing_modulation> <https://w3id.org/biolink/vocab/CausalMechanismQualifierEnum#gtpase_activation> <https://w3id.org/biolink/vocab/CausalMechanismQualifierEnum#atpase_activation> <https://w3id.org/biolink/vocab/CausalMechanismQualifierEnum#antisense_oligonucleotide_inhibition> <https://w3id.org/biolink/vocab/CausalMechanismQualifierEnum#rna_interference_inhibition> <https://w3id.org/biolink/vocab/CausalMechanismQualifierEnum#suppression> <https://w3id.org/biolink/vocab/CausalMechanismQualifierEnum#feedback_inhibition> <https://w3id.org/biolink/vocab/CausalMechanismQualifierEnum#inhibition> <https://w3id.org/biolink/vocab/CausalMechanismQualifierEnum#antibody_inhibition> <https://w3id.org/biolink/vocab/CausalMechanismQualifierEnum#antagonism> <https://w3id.org/biolink/vocab/CausalMechanismQualifierEnum#allosteric_antagonism> <https://w3id.org/biolink/vocab/CausalMechanismQualifierEnum#non_competitive_antagonism> <https://w3id.org/biolink/vocab/CausalMechanismQualifierEnum#competitive_inhibition> <https://w3id.org/biolink/vocab/CausalMechanismQualifierEnum#noncompetitive_inhibition> <https://w3id.org/biolink/vocab/CausalMechanismQualifierEnum#negative_allosteric_modulation> <https://w3id.org/biolink/vocab/CausalMechanismQualifierEnum#gating_inhibition> <https://w3id.org/biolink/vocab/CausalMechanismQualifierEnum#irreversible_inhibition> <https://w3id.org/biolink/vocab/CausalMechanismQualifierEnum#molecular_channel_blockage> <https://w3id.org/biolink/vocab/CausalMechanismQualifierEnum#inverse_agonism> <https://w3id.org/biolink/vocab/CausalMechanismQualifierEnum#binding> <https://w3id.org/biolink/vocab/CausalMechanismQualifierEnum#covalent_binding> <https://w3id.org/biolink/vocab/CausalMechanismQualifierEnum#adduction> <https://w3id.org/biolink/vocab/CausalMechanismQualifierEnum#crosslinking> <https://w3id.org/biolink/vocab/CausalMechanismQualifierEnum#transglutamination> <https://w3id.org/biolink/vocab/CausalMechanismQualifierEnum#disuphide_binding> <https://w3id.org/biolink/vocab/CausalMechanismQualifierEnum#stabilization> <https://w3id.org/biolink/vocab/CausalMechanismQualifierEnum#chaperone_mediated_stabilization> <https://w3id.org/biolink/vocab/CausalMechanismQualifierEnum#destabilization> <https://w3id.org/biolink/vocab/CausalMechanismQualifierEnum#degradation> <https://w3id.org/biolink/vocab/CausalMechanismQualifierEnum#cleavage> <https://w3id.org/biolink/vocab/CausalMechanismQualifierEnum#hydrolysis> <https://w3id.org/biolink/vocab/CausalMechanismQualifierEnum#disruption> <https://w3id.org/biolink/vocab/CausalMechanismQualifierEnum#opening> <https://w3id.org/biolink/vocab/CausalMechanismQualifierEnum#multitarget_modulation> <https://w3id.org/biolink/vocab/CausalMechanismQualifierEnum#chelation> <https://w3id.org/biolink/vocab/CausalMechanismQualifierEnum#release> <https://w3id.org/biolink/vocab/CausalMechanismQualifierEnum#sequestration> <https://w3id.org/biolink/vocab/CausalMechanismQualifierEnum#oxidoreduction> <https://w3id.org/biolink/vocab/CausalMechanismQualifierEnum#exogenous_protein> <https://w3id.org/biolink/vocab/CausalMechanismQualifierEnum#exogenous_gene> <https://w3id.org/biolink/vocab/CausalMechanismQualifierEnum#transcriptional_regulation> <https://w3id.org/biolink/vocab/CausalMechanismQualifierEnum#translational_regulation> <https://w3id.org/biolink/vocab/CausalMechanismQualifierEnum#catalytic_activity> <https://w3id.org/biolink/vocab/CausalMechanismQualifierEnum#chemical_modification> <https://w3id.org/biolink/vocab/CausalMechanismQualifierEnum#relocalization> <https://w3id.org/biolink/vocab/CausalMechanismQualifierEnum#isomerization> <https://w3id.org/biolink/vocab/CausalMechanismQualifierEnum#signaling_mediated_control> <https://w3id.org/biolink/vocab/CausalMechanismQualifierEnum#immune_system_modulation> <https://w3id.org/biolink/vocab/CausalMechanismQualifierEnum#vaccine_antigen> <https://w3id.org/biolink/vocab/CausalMechanismQualifierEnum#post_transcriptional_regulation> <https://w3id.org/biolink/vocab/CausalMechanismQualifierEnum#molecular_modification> <https://w3id.org/biolink/vocab/CausalMechanismQualifierEnum#phosphorylation> <https://w3id.org/biolink/vocab/CausalMechanismQualifierEnum#dephosphorylation> <https://w3id.org/biolink/vocab/CausalMechanismQualifierEnum#neddylation> <https://w3id.org/biolink/vocab/CausalMechanismQualifierEnum#deneddylation> <https://w3id.org/biolink/vocab/CausalMechanismQualifierEnum#lipidation> <https://w3id.org/biolink/vocab/CausalMechanismQualifierEnum#palmitoylation> <https://w3id.org/biolink/vocab/CausalMechanismQualifierEnum#myristoylation> <https://w3id.org/biolink/vocab/CausalMechanismQualifierEnum#tyrosination> <https://w3id.org/biolink/vocab/CausalMechanismQualifierEnum#carboxylation> <https://w3id.org/biolink/vocab/CausalMechanismQualifierEnum#ubiquitination> <https://w3id.org/biolink/vocab/CausalMechanismQualifierEnum#monoubiquitination> <https://w3id.org/biolink/vocab/CausalMechanismQualifierEnum#polyubiquitination> <https://w3id.org/biolink/vocab/CausalMechanismQualifierEnum#deubiquitination> <https://w3id.org/biolink/vocab/CausalMechanismQualifierEnum#sulfation> <https://w3id.org/biolink/vocab/CausalMechanismQualifierEnum#reduction> <https://w3id.org/biolink/vocab/CausalMechanismQualifierEnum#oxidation> <https://w3id.org/biolink/vocab/CausalMechanismQualifierEnum#acetylation> <https://w3id.org/biolink/vocab/CausalMechanismQualifierEnum#deacetylation> <https://w3id.org/biolink/vocab/CausalMechanismQualifierEnum#glycosylation> <https://w3id.org/biolink/vocab/CausalMechanismQualifierEnum#deglycosylation> <https://w3id.org/biolink/vocab/CausalMechanismQualifierEnum#methylation> <https://w3id.org/biolink/vocab/CausalMechanismQualifierEnum#trimethylation> <https://w3id.org/biolink/vocab/CausalMechanismQualifierEnum#demethylation> <https://w3id.org/biolink/vocab/CausalMechanismQualifierEnum#sumoylation> <https://w3id.org/biolink/vocab/CausalMechanismQualifierEnum#desumoylation> <https://w3id.org/biolink/vocab/CausalMechanismQualifierEnum#ADP-ribosylation> <https://w3id.org/biolink/vocab/CausalMechanismQualifierEnum#de-ADP-ribosylation> <https://w3id.org/biolink/vocab/CausalMechanismQualifierEnum#ampylation> <https://w3id.org/biolink/vocab/CausalMechanismQualifierEnum#hydroxylation> <https://w3id.org/biolink/vocab/CausalMechanismQualifierEnum#s_nitrosylation> ) ;
    skos:definition "An enumeration used as a qualifier to specify the causal or pharmacologic mechanism by which an effect is exerted in an association (e.g., agonism, antagonism, inverse agonism, allosteric modulation, activation, inhibition, and their competitive or partial variants)." ;
    skos:inScheme biolink: ;
    linkml:permissible_values <https://w3id.org/biolink/vocab/CausalMechanismQualifierEnum#ADP-ribosylation>,
        <https://w3id.org/biolink/vocab/CausalMechanismQualifierEnum#acetylation>,
        <https://w3id.org/biolink/vocab/CausalMechanismQualifierEnum#activation>,
        <https://w3id.org/biolink/vocab/CausalMechanismQualifierEnum#adduction>,
        <https://w3id.org/biolink/vocab/CausalMechanismQualifierEnum#agonism>,
        <https://w3id.org/biolink/vocab/CausalMechanismQualifierEnum#allosteric_antagonism>,
        <https://w3id.org/biolink/vocab/CausalMechanismQualifierEnum#allosteric_modulation>,
        <https://w3id.org/biolink/vocab/CausalMechanismQualifierEnum#ampylation>,
        <https://w3id.org/biolink/vocab/CausalMechanismQualifierEnum#antagonism>,
        <https://w3id.org/biolink/vocab/CausalMechanismQualifierEnum#antibody_agonism>,
        <https://w3id.org/biolink/vocab/CausalMechanismQualifierEnum#antibody_inhibition>,
        <https://w3id.org/biolink/vocab/CausalMechanismQualifierEnum#antisense_oligonucleotide_inhibition>,
        <https://w3id.org/biolink/vocab/CausalMechanismQualifierEnum#atpase_activation>,
        <https://w3id.org/biolink/vocab/CausalMechanismQualifierEnum#biased_agonism>,
        <https://w3id.org/biolink/vocab/CausalMechanismQualifierEnum#binding>,
        <https://w3id.org/biolink/vocab/CausalMechanismQualifierEnum#biphasic_allosteric_modulation>,
        <https://w3id.org/biolink/vocab/CausalMechanismQualifierEnum#carboxylation>,
        <https://w3id.org/biolink/vocab/CausalMechanismQualifierEnum#catalytic_activity>,
        <https://w3id.org/biolink/vocab/CausalMechanismQualifierEnum#chaperone_mediated_stabilization>,
        <https://w3id.org/biolink/vocab/CausalMechanismQualifierEnum#chelation>,
        <https://w3id.org/biolink/vocab/CausalMechanismQualifierEnum#chemical_modification>,
        <https://w3id.org/biolink/vocab/CausalMechanismQualifierEnum#cleavage>,
        <https://w3id.org/biolink/vocab/CausalMechanismQualifierEnum#cofactor>,
        <https://w3id.org/biolink/vocab/CausalMechanismQualifierEnum#competitive_inhibition>,
        <https://w3id.org/biolink/vocab/CausalMechanismQualifierEnum#covalent_binding>,
        <https://w3id.org/biolink/vocab/CausalMechanismQualifierEnum#crosslinking>,
        <https://w3id.org/biolink/vocab/CausalMechanismQualifierEnum#de-ADP-ribosylation>,
        <https://w3id.org/biolink/vocab/CausalMechanismQualifierEnum#deacetylation>,
        <https://w3id.org/biolink/vocab/CausalMechanismQualifierEnum#deglycosylation>,
        <https://w3id.org/biolink/vocab/CausalMechanismQualifierEnum#degradation>,
        <https://w3id.org/biolink/vocab/CausalMechanismQualifierEnum#demethylation>,
        <https://w3id.org/biolink/vocab/CausalMechanismQualifierEnum#deneddylation>,
        <https://w3id.org/biolink/vocab/CausalMechanismQualifierEnum#dephosphorylation>,
        <https://w3id.org/biolink/vocab/CausalMechanismQualifierEnum#destabilization>,
        <https://w3id.org/biolink/vocab/CausalMechanismQualifierEnum#desumoylation>,
        <https://w3id.org/biolink/vocab/CausalMechanismQualifierEnum#deubiquitination>,
        <https://w3id.org/biolink/vocab/CausalMechanismQualifierEnum#disruption>,
        <https://w3id.org/biolink/vocab/CausalMechanismQualifierEnum#disuphide_binding>,
        <https://w3id.org/biolink/vocab/CausalMechanismQualifierEnum#exogenous_gene>,
        <https://w3id.org/biolink/vocab/CausalMechanismQualifierEnum#exogenous_protein>,
        <https://w3id.org/biolink/vocab/CausalMechanismQualifierEnum#feedback_inhibition>,
        <https://w3id.org/biolink/vocab/CausalMechanismQualifierEnum#gating_inhibition>,
        <https://w3id.org/biolink/vocab/CausalMechanismQualifierEnum#glycosylation>,
        <https://w3id.org/biolink/vocab/CausalMechanismQualifierEnum#gtpase_activation>,
        <https://w3id.org/biolink/vocab/CausalMechanismQualifierEnum#guanyl_nucleotide_exchange>,
        <https://w3id.org/biolink/vocab/CausalMechanismQualifierEnum#hydrolysis>,
        <https://w3id.org/biolink/vocab/CausalMechanismQualifierEnum#hydroxylation>,
        <https://w3id.org/biolink/vocab/CausalMechanismQualifierEnum#immune_system_modulation>,
        <https://w3id.org/biolink/vocab/CausalMechanismQualifierEnum#induction>,
        <https://w3id.org/biolink/vocab/CausalMechanismQualifierEnum#inhibition>,
        <https://w3id.org/biolink/vocab/CausalMechanismQualifierEnum#inverse_agonism>,
        <https://w3id.org/biolink/vocab/CausalMechanismQualifierEnum#irreversible_inhibition>,
        <https://w3id.org/biolink/vocab/CausalMechanismQualifierEnum#isomerization>,
        <https://w3id.org/biolink/vocab/CausalMechanismQualifierEnum#lipidation>,
        <https://w3id.org/biolink/vocab/CausalMechanismQualifierEnum#methylation>,
        <https://w3id.org/biolink/vocab/CausalMechanismQualifierEnum#mixed_agonism>,
        <https://w3id.org/biolink/vocab/CausalMechanismQualifierEnum#mixed_allosteric_modulation>,
        <https://w3id.org/biolink/vocab/CausalMechanismQualifierEnum#modulation>,
        <https://w3id.org/biolink/vocab/CausalMechanismQualifierEnum#molecular_channel_blockage>,
        <https://w3id.org/biolink/vocab/CausalMechanismQualifierEnum#molecular_channel_opening>,
        <https://w3id.org/biolink/vocab/CausalMechanismQualifierEnum#molecular_modification>,
        <https://w3id.org/biolink/vocab/CausalMechanismQualifierEnum#monoubiquitination>,
        <https://w3id.org/biolink/vocab/CausalMechanismQualifierEnum#multitarget_modulation>,
        <https://w3id.org/biolink/vocab/CausalMechanismQualifierEnum#myristoylation>,
        <https://w3id.org/biolink/vocab/CausalMechanismQualifierEnum#neddylation>,
        <https://w3id.org/biolink/vocab/CausalMechanismQualifierEnum#negative_allosteric_modulation>,
        <https://w3id.org/biolink/vocab/CausalMechanismQualifierEnum#negative_gene_editing_modulation>,
        <https://w3id.org/biolink/vocab/CausalMechanismQualifierEnum#negative_modulation>,
        <https://w3id.org/biolink/vocab/CausalMechanismQualifierEnum#non_competitive_antagonism>,
        <https://w3id.org/biolink/vocab/CausalMechanismQualifierEnum#noncompetitive_inhibition>,
        <https://w3id.org/biolink/vocab/CausalMechanismQualifierEnum#opening>,
        <https://w3id.org/biolink/vocab/CausalMechanismQualifierEnum#oxidation>,
        <https://w3id.org/biolink/vocab/CausalMechanismQualifierEnum#oxidoreduction>,
        <https://w3id.org/biolink/vocab/CausalMechanismQualifierEnum#palmitoylation>,
        <https://w3id.org/biolink/vocab/CausalMechanismQualifierEnum#partial_agonism>,
        <https://w3id.org/biolink/vocab/CausalMechanismQualifierEnum#phosphorylation>,
        <https://w3id.org/biolink/vocab/CausalMechanismQualifierEnum#polyubiquitination>,
        <https://w3id.org/biolink/vocab/CausalMechanismQualifierEnum#positive_allosteric_modulation>,
        <https://w3id.org/biolink/vocab/CausalMechanismQualifierEnum#positive_modulation>,
        <https://w3id.org/biolink/vocab/CausalMechanismQualifierEnum#post_transcriptional_regulation>,
        <https://w3id.org/biolink/vocab/CausalMechanismQualifierEnum#potentiation>,
        <https://w3id.org/biolink/vocab/CausalMechanismQualifierEnum#reduction>,
        <https://w3id.org/biolink/vocab/CausalMechanismQualifierEnum#release>,
        <https://w3id.org/biolink/vocab/CausalMechanismQualifierEnum#relocalization>,
        <https://w3id.org/biolink/vocab/CausalMechanismQualifierEnum#rna_interference_inhibition>,
        <https://w3id.org/biolink/vocab/CausalMechanismQualifierEnum#s_nitrosylation>,
        <https://w3id.org/biolink/vocab/CausalMechanismQualifierEnum#sequestration>,
        <https://w3id.org/biolink/vocab/CausalMechanismQualifierEnum#signaling_mediated_control>,
        <https://w3id.org/biolink/vocab/CausalMechanismQualifierEnum#stabilization>,
        <https://w3id.org/biolink/vocab/CausalMechanismQualifierEnum#stimulation>,
        <https://w3id.org/biolink/vocab/CausalMechanismQualifierEnum#sulfation>,
        <https://w3id.org/biolink/vocab/CausalMechanismQualifierEnum#sumoylation>,
        <https://w3id.org/biolink/vocab/CausalMechanismQualifierEnum#suppression>,
        <https://w3id.org/biolink/vocab/CausalMechanismQualifierEnum#transcriptional_regulation>,
        <https://w3id.org/biolink/vocab/CausalMechanismQualifierEnum#transglutamination>,
        <https://w3id.org/biolink/vocab/CausalMechanismQualifierEnum#translational_regulation>,
        <https://w3id.org/biolink/vocab/CausalMechanismQualifierEnum#trimethylation>,
        <https://w3id.org/biolink/vocab/CausalMechanismQualifierEnum#tyrosination>,
        <https://w3id.org/biolink/vocab/CausalMechanismQualifierEnum#ubiquitination>,
        <https://w3id.org/biolink/vocab/CausalMechanismQualifierEnum#vaccine_antigen> .

biolink:node_property a owl:DatatypeProperty ;
    rdfs:label "node property" ;
    rdfs:domain biolink:NamedThing ;
    skos:definition "A grouping for any property that holds between a node and a value" ;
    skos:inScheme biolink: .

biolink:predicate a owl:DatatypeProperty ;
    rdfs:label "predicate" ;
    rdfs:range xsd:anyURI ;
    rdfs:subPropertyOf biolink:association_slot ;
    skos:definition "Has a value from the Biolink 'related_to' hierarchy. In RDF,  this corresponds to rdf:predicate and in Neo4j this corresponds to the relationship type. The convention is for an edge label in snake_case form. For example, biolink:related_to, biolink:causes, biolink:treats" ;
    skos:exactMatch OBAN:association_has_predicate,
        owl:annotatedProperty ;
    skos:inScheme biolink: .

xsd:string a rdfs:Datatype ;
    owl:equivalentClass xsd:anyURI,
        xsd:time .

biolink:category a owl:DatatypeProperty ;
    rdfs:label "category" ;
    rdfs:domain biolink:Entity ;
    rdfs:range xsd:anyURI ;
    rdfs:subPropertyOf biolink:type ;
    skos:definition "Name of the high level ontology class in which this entity is categorized. Corresponds to the label for the biolink entity type class. In a neo4j database this MAY correspond to the neo4j label tag. In an RDF database it should be a biolink model class URI. This field is multi-valued. It should include values for ancestors of the biolink class; for example, a protein such as Shh would have category values `biolink:Protein`, `biolink:GeneProduct`, `biolink:MolecularEntity`. In an RDF database, nodes will typically have an rdf:type triples. This can be to the most specific biolink class, or potentially to a class more specific than something in biolink. For example, a sequence feature `f` may have a rdf:type assertion to a SO class such as TF_binding_site, which is more specific than anything in biolink. Here we would have categories {biolink:GenomicEntity, biolink:MolecularEntity, biolink:NamedThing}" ;
    skos:inScheme biolink: .

biolink:object a owl:ObjectProperty ;
    rdfs:label "object" ;
    rdfs:domain biolink:Association ;
    rdfs:range biolink:NamedThing ;
    rdfs:subPropertyOf biolink:association_slot ;
    skos:definition "connects an association to the object of the association. For example, in a gene-to-phenotype association, the gene is subject and phenotype is object." ;
    skos:exactMatch OBAN:association_has_object,
        owl:annotatedTarget ;
    skos:inScheme biolink: .

biolink:subject a owl:ObjectProperty ;
    rdfs:label "subject" ;
    rdfs:domain biolink:Association ;
    rdfs:range biolink:NamedThing ;
    rdfs:subPropertyOf biolink:association_slot ;
    skos:definition "connects an association to the subject of the association. For example, in a gene-to-phenotype association, the gene is subject and phenotype is object." ;
    skos:exactMatch OBAN:association_has_subject,
        owl:annotatedSource ;
    skos:inScheme biolink: .

[] a owl:Restriction ;
    rdfs:subClassOf biolink:ContributorAssociation ;
    owl:onProperty biolink:category ;
    owl:someValuesFrom biolink:ContributorAssociation .

[] a owl:Restriction ;
    rdfs:subClassOf biolink:ChemicalEntityToBiologicalProcessAssociation ;
    owl:onProperty biolink:category ;
    owl:someValuesFrom biolink:ChemicalEntityToBiologicalProcessAssociation .

[] a owl:Restriction ;
    rdfs:subClassOf biolink:GrossAnatomicalStructure ;
    owl:onProperty biolink:category ;
    owl:someValuesFrom biolink:GrossAnatomicalStructure .

[] a owl:Restriction ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:minCardinality 1 ;
            owl:onProperty biolink:predicate ],
        [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:subject ],
        [ a owl:Restriction ;
            owl:minCardinality 1 ;
            owl:onProperty biolink:object ],
        [ a owl:Restriction ;
            owl:allValuesFrom xsd:anyURI ;
            owl:onProperty biolink:predicate ],
        [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:object ],
        [ a owl:Restriction ;
            owl:allValuesFrom biolink:Case ;
            owl:onProperty biolink:subject ],
        [ a owl:Restriction ;
            owl:allValuesFrom biolink:NamedThing ;
            owl:onProperty biolink:object ],
        [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:predicate ],
        [ a owl:Restriction ;
            owl:minCardinality 1 ;
            owl:onProperty biolink:subject ] ;
    owl:onProperty linkml:mixins ;
    owl:someValuesFrom biolink:CaseToEntityAssociationMixin .

[] a owl:Restriction ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:allValuesFrom biolink:Disease ;
            owl:onProperty biolink:object ],
        [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:object ],
        [ a owl:Restriction ;
            owl:minCardinality 1 ;
            owl:onProperty biolink:object ] ;
    owl:onProperty linkml:mixins ;
    owl:someValuesFrom biolink:EntityToDiseaseAssociationMixin .

[] a owl:Restriction ;
    rdfs:subClassOf biolink:InformationContentEntityToNamedThingAssociation ;
    owl:onProperty biolink:category ;
    owl:someValuesFrom biolink:InformationContentEntityToNamedThingAssociation .

[] a owl:Restriction ;
    rdfs:subClassOf biolink:BiologicalEntity ;
    owl:onProperty biolink:category ;
    owl:someValuesFrom biolink:BiologicalEntity .

[] a owl:Restriction ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:allValuesFrom biolink:Drug ;
            owl:onProperty biolink:subject ],
        [ a owl:Restriction ;
            owl:allValuesFrom xsd:anyURI ;
            owl:onProperty biolink:predicate ],
        [ a owl:Restriction ;
            owl:minCardinality 1 ;
            owl:onProperty biolink:subject ],
        [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:object ],
        [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:subject ],
        [ a owl:Restriction ;
            owl:minCardinality 1 ;
            owl:onProperty biolink:predicate ],
        [ a owl:Restriction ;
            owl:minCardinality 1 ;
            owl:onProperty biolink:object ],
        [ a owl:Restriction ;
            owl:allValuesFrom biolink:NamedThing ;
            owl:onProperty biolink:object ],
        [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:predicate ] ;
    owl:onProperty linkml:mixins ;
    owl:someValuesFrom biolink:DrugToEntityAssociationMixin .

[] a owl:Restriction ;
    rdfs:subClassOf biolink:OrganismToOrganismAssociation ;
    owl:onProperty biolink:category ;
    owl:someValuesFrom biolink:OrganismToOrganismAssociation .

[] a owl:Restriction ;
    rdfs:subClassOf biolink:NucleicAcidSequenceMotif ;
    owl:onProperty biolink:category ;
    owl:someValuesFrom biolink:NucleicAcidSequenceMotif .

[] a owl:Restriction ;
    rdfs:subClassOf biolink:ChemicalEntityOrGeneOrGeneProductRegulatesGeneAssociation ;
    owl:onProperty biolink:category ;
    owl:someValuesFrom biolink:ChemicalEntityOrGeneOrGeneProductRegulatesGeneAssociation .

[] a owl:Restriction ;
    owl:onProperty linkml:mixins ;
    owl:someValuesFrom biolink:GeneOrGeneProductOrGeneFamily .

[] a owl:Restriction ;
    rdfs:subClassOf biolink:Activity ;
    owl:onProperty biolink:category ;
    owl:someValuesFrom biolink:Activity .

[] a owl:Restriction ;
    rdfs:subClassOf biolink:GeneOrGeneProductOrGeneFamilyToAnatomicalEntityAssociation ;
    owl:onProperty biolink:category ;
    owl:someValuesFrom biolink:GeneOrGeneProductOrGeneFamilyToAnatomicalEntityAssociation .

[] a owl:Restriction ;
    rdfs:subClassOf biolink:ProteinDomain ;
    owl:onProperty biolink:category ;
    owl:someValuesFrom biolink:ProteinDomain .

[] a owl:Restriction ;
    rdfs:subClassOf biolink:Haplotype ;
    owl:onProperty biolink:category ;
    owl:someValuesFrom biolink:Haplotype .

[] a owl:Restriction ;
    rdfs:subClassOf biolink:DiseaseOrPhenotypicFeatureToLocationAssociation ;
    owl:onProperty biolink:category ;
    owl:someValuesFrom biolink:DiseaseOrPhenotypicFeatureToLocationAssociation .

[] a owl:Restriction ;
    rdfs:subClassOf biolink:GeneToGeneHomologyAssociation ;
    owl:onProperty biolink:category ;
    owl:someValuesFrom biolink:GeneToGeneHomologyAssociation .

[] a owl:Restriction ;
    rdfs:subClassOf biolink:GeneOrGeneProductOrGeneFamilyToBiologicalProcessOrActivityAssociation ;
    owl:onProperty biolink:category ;
    owl:someValuesFrom biolink:GeneOrGeneProductOrGeneFamilyToBiologicalProcessOrActivityAssociation .

[] a owl:Restriction ;
    rdfs:subClassOf biolink:GeneFamilyToGeneOrGeneProductOrGeneFamilyAssociation ;
    owl:onProperty biolink:category ;
    owl:someValuesFrom biolink:GeneFamilyToGeneOrGeneProductOrGeneFamilyAssociation .

[] a owl:Restriction ;
    rdfs:subClassOf biolink:NucleosomeModification ;
    owl:onProperty biolink:category ;
    owl:someValuesFrom biolink:NucleosomeModification .

[] a owl:Restriction ;
    rdfs:subClassOf biolink:BookChapter ;
    owl:onProperty biolink:category ;
    owl:someValuesFrom biolink:BookChapter .

[] a owl:Restriction ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:subject ],
        [ a owl:Restriction ;
            owl:minCardinality 0 ;
            owl:onProperty biolink:sex_qualifier ],
        [ a owl:Restriction ;
            owl:allValuesFrom biolink:BiologicalSex ;
            owl:onProperty biolink:sex_qualifier ],
        [ a owl:Restriction ;
            owl:minCardinality 1 ;
            owl:onProperty biolink:subject ],
        [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:sex_qualifier ],
        [ a owl:Restriction ;
            owl:allValuesFrom biolink:PhenotypicFeature ;
            owl:onProperty biolink:subject ] ;
    owl:onProperty linkml:mixins ;
    owl:someValuesFrom biolink:PhenotypicFeatureToEntityAssociationMixin .

[] a owl:Restriction ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:allValuesFrom xsd:anyURI ;
            owl:onProperty biolink:predicate ],
        [ a owl:Restriction ;
            owl:allValuesFrom biolink:NamedThing ;
            owl:onProperty biolink:object ],
        [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:object ],
        [ a owl:Restriction ;
            owl:allValuesFrom biolink:ChemicalEntityOrGeneOrGeneProduct ;
            owl:onProperty biolink:subject ],
        [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:subject ],
        [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:predicate ],
        [ a owl:Restriction ;
            owl:minCardinality 1 ;
            owl:onProperty biolink:subject ],
        [ a owl:Restriction ;
            owl:minCardinality 1 ;
            owl:onProperty biolink:object ],
        [ a owl:Restriction ;
            owl:minCardinality 1 ;
            owl:onProperty biolink:predicate ] ;
    owl:onProperty linkml:mixins ;
    owl:someValuesFrom biolink:ChemicalEntityToEntityAssociationMixin .

[] a owl:Restriction ;
    rdfs:subClassOf biolink:ProcessedMaterial ;
    owl:onProperty biolink:category ;
    owl:someValuesFrom biolink:ProcessedMaterial .

[] a owl:Restriction ;
    rdfs:subClassOf biolink:AnatomicalEntityToAnatomicalEntityOntogenicAssociation ;
    owl:onProperty biolink:category ;
    owl:someValuesFrom biolink:AnatomicalEntityToAnatomicalEntityOntogenicAssociation .

[] a owl:Restriction ;
    rdfs:subClassOf biolink:RNAProduct ;
    owl:onProperty biolink:category ;
    owl:someValuesFrom biolink:RNAProduct .

[] a owl:Restriction ;
    rdfs:subClassOf biolink:Hospitalization ;
    owl:onProperty biolink:category ;
    owl:someValuesFrom biolink:Hospitalization .

[] a owl:Restriction ;
    rdfs:subClassOf biolink:ConceptCountAnalysisResult ;
    owl:onProperty biolink:category ;
    owl:someValuesFrom biolink:ConceptCountAnalysisResult .

[] a owl:Restriction ;
    rdfs:subClassOf biolink:DiagnosticAid ;
    owl:onProperty biolink:category ;
    owl:someValuesFrom biolink:DiagnosticAid .

[] a owl:Restriction ;
    rdfs:subClassOf biolink:TaxonToTaxonAssociation ;
    owl:onProperty biolink:category ;
    owl:someValuesFrom biolink:TaxonToTaxonAssociation .

[] a owl:Restriction ;
    owl:onProperty linkml:mixins ;
    owl:someValuesFrom biolink:ActivityAndBehavior .

[] a owl:Restriction ;
    rdfs:subClassOf biolink:Cohort ;
    owl:onProperty biolink:category ;
    owl:someValuesFrom biolink:Cohort .

[] a owl:Restriction ;
    rdfs:subClassOf biolink:BiologicalProcessOrActivity ;
    owl:onProperty biolink:category ;
    owl:someValuesFrom biolink:BiologicalProcessOrActivity .

[] a owl:Restriction ;
    rdfs:subClassOf biolink:StudyVariable ;
    owl:onProperty biolink:category ;
    owl:someValuesFrom biolink:StudyVariable .

[] a owl:Restriction ;
    rdfs:subClassOf biolink:GeographicLocationAtTime ;
    owl:onProperty biolink:category ;
    owl:someValuesFrom biolink:GeographicLocationAtTime .

[] a owl:Restriction ;
    rdfs:subClassOf biolink:GenomicBackgroundExposure ;
    owl:onProperty biolink:category ;
    owl:someValuesFrom biolink:GenomicBackgroundExposure .

[] a owl:Restriction ;
    rdfs:subClassOf biolink:EvidenceType ;
    owl:onProperty biolink:category ;
    owl:someValuesFrom biolink:EvidenceType .

[] a owl:Restriction ;
    rdfs:subClassOf biolink:RNAProductIsoform ;
    owl:onProperty biolink:category ;
    owl:someValuesFrom biolink:RNAProductIsoform .

[] a owl:Restriction ;
    rdfs:subClassOf biolink:CodingSequence ;
    owl:onProperty biolink:category ;
    owl:someValuesFrom biolink:CodingSequence .

[] a owl:Restriction ;
    rdfs:subClassOf biolink:BiologicalProcess ;
    owl:onProperty biolink:category ;
    owl:someValuesFrom biolink:BiologicalProcess .

[] a owl:Restriction ;
    rdfs:subClassOf biolink:DiseaseToExposureEventAssociation ;
    owl:onProperty biolink:category ;
    owl:someValuesFrom biolink:DiseaseToExposureEventAssociation .

[] a owl:Restriction ;
    rdfs:subClassOf biolink:ExposureEventToOutcomeAssociation ;
    owl:onProperty biolink:category ;
    owl:someValuesFrom biolink:ExposureEventToOutcomeAssociation .

[] a owl:Restriction ;
    rdfs:subClassOf biolink:MacromolecularMachineToMolecularActivityAssociation ;
    owl:onProperty biolink:category ;
    owl:someValuesFrom biolink:MacromolecularMachineToMolecularActivityAssociation .

[] a owl:Restriction ;
    rdfs:subClassOf biolink:Polypeptide ;
    owl:onProperty biolink:category ;
    owl:someValuesFrom biolink:Polypeptide .

[] a owl:Restriction ;
    rdfs:subClassOf biolink:Exon ;
    owl:onProperty biolink:category ;
    owl:someValuesFrom biolink:Exon .

[] a owl:Restriction ;
    rdfs:subClassOf biolink:Mammal ;
    owl:onProperty biolink:category ;
    owl:someValuesFrom biolink:Mammal .

[] a owl:Restriction ;
    rdfs:subClassOf biolink:Genome ;
    owl:onProperty biolink:category ;
    owl:someValuesFrom biolink:Genome .

[] a owl:Restriction ;
    rdfs:subClassOf biolink:GeneToGeneProductRelationship ;
    owl:onProperty biolink:category ;
    owl:someValuesFrom biolink:GeneToGeneProductRelationship .

[] a owl:Restriction ;
    rdfs:subClassOf biolink:CausalGeneToDiseaseAssociation ;
    owl:onProperty biolink:category ;
    owl:someValuesFrom biolink:CausalGeneToDiseaseAssociation .

[] a owl:Restriction ;
    rdfs:subClassOf biolink:PosttranslationalModification ;
    owl:onProperty biolink:category ;
    owl:someValuesFrom biolink:PosttranslationalModification .

[] a owl:Restriction ;
    rdfs:subClassOf biolink:ChemicalRole ;
    owl:onProperty biolink:category ;
    owl:someValuesFrom biolink:ChemicalRole .

[] a owl:Restriction ;
    rdfs:subClassOf biolink:Phenomenon ;
    owl:onProperty biolink:category ;
    owl:someValuesFrom biolink:Phenomenon .

[] a owl:Restriction ;
    rdfs:subClassOf biolink:ProcessRegulatesProcessAssociation ;
    owl:onProperty biolink:category ;
    owl:someValuesFrom biolink:ProcessRegulatesProcessAssociation .

[] a owl:Restriction ;
    rdfs:subClassOf biolink:CaseToPhenotypicFeatureAssociation ;
    owl:onProperty biolink:category ;
    owl:someValuesFrom biolink:CaseToPhenotypicFeatureAssociation .

[] a owl:Restriction ;
    rdfs:subClassOf biolink:MaterialSample ;
    owl:onProperty biolink:category ;
    owl:someValuesFrom biolink:MaterialSample .

[] a owl:Restriction ;
    rdfs:subClassOf biolink:ClinicalEntity ;
    owl:onProperty biolink:category ;
    owl:someValuesFrom biolink:ClinicalEntity .

[] a owl:Restriction ;
    rdfs:subClassOf biolink:IndividualOrganism ;
    owl:onProperty biolink:category ;
    owl:someValuesFrom biolink:IndividualOrganism .

[] a owl:Restriction ;
    rdfs:subClassOf biolink:BehaviorToBehavioralFeatureAssociation ;
    owl:onProperty biolink:category ;
    owl:someValuesFrom biolink:BehaviorToBehavioralFeatureAssociation .

[] a owl:Restriction ;
    rdfs:subClassOf biolink:EntityToPhenotypicFeatureAssociation ;
    owl:onProperty biolink:category ;
    owl:someValuesFrom biolink:EntityToPhenotypicFeatureAssociation .

[] a owl:Restriction ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:minCardinality 0 ;
            owl:onProperty biolink:name ],
        [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:name ],
        [ a owl:Restriction ;
            owl:allValuesFrom xsd:string ;
            owl:onProperty biolink:name ] ;
    owl:onProperty linkml:mixins ;
    owl:someValuesFrom biolink:MacromolecularMachineMixin .

[] a owl:Restriction ;
    rdfs:subClassOf biolink:MolecularActivityToChemicalEntityAssociation ;
    owl:onProperty biolink:category ;
    owl:someValuesFrom biolink:MolecularActivityToChemicalEntityAssociation .

[] a owl:Restriction ;
    owl:onProperty linkml:mixins ;
    owl:someValuesFrom biolink:GeneOrGeneProduct .

[] a owl:Restriction ;
    rdfs:subClassOf biolink:ExposureEventToPhenotypicFeatureAssociation ;
    owl:onProperty biolink:category ;
    owl:someValuesFrom biolink:ExposureEventToPhenotypicFeatureAssociation .

[] a owl:Restriction ;
    rdfs:subClassOf biolink:ClinicalMeasurement ;
    owl:onProperty biolink:category ;
    owl:someValuesFrom biolink:ClinicalMeasurement .

[] a owl:Restriction ;
    rdfs:subClassOf biolink:Zygosity ;
    owl:onProperty biolink:category ;
    owl:someValuesFrom biolink:Zygosity .

[] a owl:Restriction ;
    rdfs:subClassOf biolink:PreprintPublication ;
    owl:onProperty biolink:category ;
    owl:someValuesFrom biolink:PreprintPublication .

[] a owl:Restriction ;
    owl:onProperty linkml:mixins ;
    owl:someValuesFrom biolink:ChemicalEntityOrGeneOrGeneProduct .

[] a owl:Restriction ;
    rdfs:subClassOf biolink:ConfidenceLevel ;
    owl:onProperty biolink:category ;
    owl:someValuesFrom biolink:ConfidenceLevel .

[] a owl:Restriction ;
    owl:onProperty linkml:mixins ;
    owl:someValuesFrom biolink:SensitivityQuantifier .

[] a owl:Restriction ;
    rdfs:subClassOf biolink:Transcript ;
    owl:onProperty biolink:category ;
    owl:someValuesFrom biolink:Transcript .

[] a owl:Restriction ;
    rdfs:subClassOf biolink:DiseaseOrPhenotypicFeatureToGeneticInheritanceAssociation ;
    owl:onProperty biolink:category ;
    owl:someValuesFrom biolink:DiseaseOrPhenotypicFeatureToGeneticInheritanceAssociation .

[] a owl:Restriction ;
    owl:onProperty linkml:mixins ;
    owl:someValuesFrom biolink:ChemicalEntityOrProteinOrPolypeptide .

[] a owl:Restriction ;
    rdfs:subClassOf biolink:PhenotypicFeatureToDiseaseAssociation ;
    owl:onProperty biolink:category ;
    owl:someValuesFrom biolink:PhenotypicFeatureToDiseaseAssociation .

[] a owl:Restriction ;
    rdfs:subClassOf biolink:Book ;
    owl:onProperty biolink:category ;
    owl:someValuesFrom biolink:Book .

[] a owl:Restriction ;
    rdfs:subClassOf biolink:ReactionToParticipantAssociation ;
    owl:onProperty biolink:category ;
    owl:someValuesFrom biolink:ReactionToParticipantAssociation .

[] a owl:Restriction ;
    rdfs:subClassOf biolink:DruggableGeneToDiseaseAssociation ;
    owl:onProperty biolink:category ;
    owl:someValuesFrom biolink:DruggableGeneToDiseaseAssociation .

[] a owl:Restriction ;
    rdfs:subClassOf biolink:NamedThingAssociatedWithLikelihoodOfNamedThingAssociation ;
    owl:onProperty biolink:category ;
    owl:someValuesFrom biolink:NamedThingAssociatedWithLikelihoodOfNamedThingAssociation .

[] a owl:Restriction ;
    rdfs:subClassOf biolink:AdministrativeEntity ;
    owl:onProperty biolink:category ;
    owl:someValuesFrom biolink:AdministrativeEntity .

[] a owl:Restriction ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:stage_qualifier ],
        [ a owl:Restriction ;
            owl:allValuesFrom biolink:OntologyClass ;
            owl:onProperty biolink:quantifier_qualifier ],
        [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:expression_site ],
        [ a owl:Restriction ;
            owl:allValuesFrom biolink:AnatomicalEntity ;
            owl:onProperty biolink:expression_site ],
        [ a owl:Restriction ;
            owl:minCardinality 0 ;
            owl:onProperty biolink:quantifier_qualifier ],
        [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:quantifier_qualifier ],
        [ a owl:Restriction ;
            owl:minCardinality 0 ;
            owl:onProperty biolink:expression_site ],
        [ a owl:Restriction ;
            owl:minCardinality 0 ;
            owl:onProperty biolink:phenotypic_state ],
        [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:phenotypic_state ],
        [ a owl:Restriction ;
            owl:allValuesFrom biolink:DiseaseOrPhenotypicFeature ;
            owl:onProperty biolink:phenotypic_state ],
        [ a owl:Restriction ;
            owl:allValuesFrom biolink:LifeStage ;
            owl:onProperty biolink:stage_qualifier ],
        [ a owl:Restriction ;
            owl:minCardinality 0 ;
            owl:onProperty biolink:stage_qualifier ] ;
    owl:onProperty linkml:mixins ;
    owl:someValuesFrom biolink:GeneExpressionMixin .

[] a owl:Restriction ;
    rdfs:subClassOf biolink:ClinicalAttribute ;
    owl:onProperty biolink:category ;
    owl:someValuesFrom biolink:ClinicalAttribute .

[] a owl:Restriction ;
    rdfs:subClassOf biolink:PhenotypicQuality ;
    owl:onProperty biolink:category ;
    owl:someValuesFrom biolink:PhenotypicQuality .

[] a owl:Restriction ;
    rdfs:subClassOf biolink:Gene ;
    owl:onProperty biolink:category ;
    owl:someValuesFrom biolink:Gene .

[] a owl:Restriction ;
    rdfs:subClassOf biolink:DrugToGeneInteractionExposure ;
    owl:onProperty biolink:category ;
    owl:someValuesFrom biolink:DrugToGeneInteractionExposure .

[] a owl:Restriction ;
    rdfs:subClassOf biolink:PhenotypicSex ;
    owl:onProperty biolink:category ;
    owl:someValuesFrom biolink:PhenotypicSex .

[] a owl:Restriction ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:has_biological_sequence ],
        [ a owl:Restriction ;
            owl:minCardinality 0 ;
            owl:onProperty biolink:has_biological_sequence ],
        [ a owl:Restriction ;
            owl:allValuesFrom xsd:string ;
            owl:onProperty biolink:has_biological_sequence ] ;
    owl:onProperty linkml:mixins ;
    owl:someValuesFrom biolink:GenomicEntity .

[] a owl:Restriction ;
    rdfs:subClassOf biolink:PathologicalAnatomicalExposure ;
    owl:onProperty biolink:category ;
    owl:someValuesFrom biolink:PathologicalAnatomicalExposure .

[] a owl:Restriction ;
    rdfs:subClassOf biolink:AnatomicalEntityToAnatomicalEntityAssociation ;
    owl:onProperty biolink:category ;
    owl:someValuesFrom biolink:AnatomicalEntityToAnatomicalEntityAssociation .

[] a owl:Restriction ;
    rdfs:subClassOf biolink:MacromolecularMachineHasSubstrateAssociation ;
    owl:onProperty biolink:category ;
    owl:someValuesFrom biolink:MacromolecularMachineHasSubstrateAssociation .

[] a owl:Restriction ;
    rdfs:subClassOf biolink:TextMiningStudyResult ;
    owl:onProperty biolink:category ;
    owl:someValuesFrom biolink:TextMiningStudyResult .

[] a owl:Restriction ;
    rdfs:subClassOf biolink:ChemicalOrDrugOrTreatmentAdverseEventAssociation ;
    owl:onProperty biolink:category ;
    owl:someValuesFrom biolink:ChemicalOrDrugOrTreatmentAdverseEventAssociation .

[] a owl:Restriction ;
    rdfs:subClassOf biolink:CaseToVariantAssociation ;
    owl:onProperty biolink:category ;
    owl:someValuesFrom biolink:CaseToVariantAssociation .

[] a owl:Restriction ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:allValuesFrom biolink:OrganismTaxon ;
            owl:onProperty biolink:species_context_qualifier ],
        [ a owl:Restriction ;
            owl:minCardinality 1 ;
            owl:onProperty biolink:subject ],
        [ a owl:Restriction ;
            owl:minCardinality 1 ;
            owl:onProperty biolink:predicate ],
        [ a owl:Restriction ;
            owl:allValuesFrom xsd:anyURI ;
            owl:onProperty biolink:predicate ],
        [ a owl:Restriction ;
            owl:allValuesFrom biolink:NamedThing ;
            owl:onProperty biolink:object ],
        [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:species_context_qualifier ],
        [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:subject ],
        [ a owl:Restriction ;
            owl:minCardinality 0 ;
            owl:onProperty biolink:species_context_qualifier ],
        [ a owl:Restriction ;
            owl:minCardinality 1 ;
            owl:onProperty biolink:object ],
        [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:object ],
        [ a owl:Restriction ;
            owl:allValuesFrom biolink:NamedThing ;
            owl:onProperty biolink:subject ],
        [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:predicate ] ;
    owl:onProperty linkml:mixins ;
    owl:someValuesFrom biolink:MacromolecularMachineToEntityAssociationMixin .

[] a owl:Restriction ;
    rdfs:subClassOf biolink:PairwiseGeneToGeneInteraction ;
    owl:onProperty biolink:category ;
    owl:someValuesFrom biolink:PairwiseGeneToGeneInteraction .

[] a owl:Restriction ;
    rdfs:subClassOf biolink:SequenceFeatureRelationship ;
    owl:onProperty biolink:category ;
    owl:someValuesFrom biolink:SequenceFeatureRelationship .

[] a owl:Restriction ;
    rdfs:subClassOf biolink:Dataset ;
    owl:onProperty biolink:category ;
    owl:someValuesFrom biolink:Dataset .

[] a owl:Restriction ;
    rdfs:subClassOf biolink:NoncodingRNAProduct ;
    owl:onProperty biolink:category ;
    owl:someValuesFrom biolink:NoncodingRNAProduct .

[] a owl:Restriction ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:minCardinality 0 ;
            owl:onProperty biolink:frequency_qualifier ],
        [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:subject ],
        [ a owl:Restriction ;
            owl:minCardinality 1 ;
            owl:onProperty biolink:object ],
        [ a owl:Restriction ;
            owl:minCardinality 1 ;
            owl:onProperty biolink:predicate ],
        [ a owl:Restriction ;
            owl:allValuesFrom biolink:NamedThing ;
            owl:onProperty biolink:subject ],
        [ a owl:Restriction ;
            owl:allValuesFrom xsd:anyURI ;
            owl:onProperty biolink:predicate ],
        [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:predicate ],
        [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:frequency_qualifier ],
        [ a owl:Restriction ;
            owl:minCardinality 1 ;
            owl:onProperty biolink:subject ],
        [ a owl:Restriction ;
            owl:allValuesFrom <http://purl.obolibrary.org/obo/UO_0000105> ;
            owl:onProperty biolink:frequency_qualifier ],
        [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:object ],
        [ a owl:Restriction ;
            owl:allValuesFrom biolink:NamedThing ;
            owl:onProperty biolink:object ] ;
    owl:onProperty linkml:mixins ;
    owl:someValuesFrom biolink:FrequencyQualifierMixin .

[] a owl:Restriction ;
    rdfs:subClassOf biolink:Procedure ;
    owl:onProperty biolink:category ;
    owl:someValuesFrom biolink:Procedure .

[] a owl:Restriction ;
    rdfs:subClassOf biolink:GenotypeToDiseaseAssociation ;
    owl:onProperty biolink:category ;
    owl:someValuesFrom biolink:GenotypeToDiseaseAssociation .

[] a owl:Restriction ;
    rdfs:subClassOf biolink:ExposureEvent ;
    owl:onProperty biolink:category ;
    owl:someValuesFrom biolink:ExposureEvent .

[] a owl:Restriction ;
    rdfs:subClassOf biolink:MaterialSampleToDiseaseOrPhenotypicFeatureAssociation ;
    owl:onProperty biolink:category ;
    owl:someValuesFrom biolink:MaterialSampleToDiseaseOrPhenotypicFeatureAssociation .

[] a owl:Restriction ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:allValuesFrom biolink:NamedThing ;
            owl:onProperty biolink:object ],
        [ a owl:Restriction ;
            owl:allValuesFrom xsd:anyURI ;
            owl:onProperty biolink:predicate ],
        [ a owl:Restriction ;
            owl:allValuesFrom biolink:NamedThing ;
            owl:onProperty biolink:subject ],
        [ a owl:Restriction ;
            owl:minCardinality 1 ;
            owl:onProperty biolink:predicate ],
        [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:predicate ],
        [ a owl:Restriction ;
            owl:minCardinality 1 ;
            owl:onProperty biolink:subject ],
        [ a owl:Restriction ;
            owl:minCardinality 1 ;
            owl:onProperty biolink:object ],
        [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:object ],
        [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:subject ] ;
    owl:onProperty linkml:mixins ;
    owl:someValuesFrom biolink:ModelToDiseaseAssociationMixin .

[] a owl:Restriction ;
    rdfs:subClassOf biolink:GenotypeToPhenotypicFeatureAssociation ;
    owl:onProperty biolink:category ;
    owl:someValuesFrom biolink:GenotypeToPhenotypicFeatureAssociation .

[] a owl:Restriction ;
    rdfs:subClassOf biolink:Genotype ;
    owl:onProperty biolink:category ;
    owl:someValuesFrom biolink:Genotype .

[] a owl:Restriction ;
    rdfs:subClassOf biolink:CellularOrganism ;
    owl:onProperty biolink:category ;
    owl:someValuesFrom biolink:CellularOrganism .

[] a owl:Restriction ;
    rdfs:subClassOf biolink:LogOddsAnalysisResult ;
    owl:onProperty biolink:category ;
    owl:someValuesFrom biolink:LogOddsAnalysisResult .

[] a owl:Restriction ;
    rdfs:subClassOf biolink:GeographicLocation ;
    owl:onProperty biolink:category ;
    owl:someValuesFrom biolink:GeographicLocation .

[] a owl:Restriction ;
    rdfs:subClassOf biolink:Disease ;
    owl:onProperty biolink:category ;
    owl:someValuesFrom biolink:Disease .

[] a owl:Restriction ;
    rdfs:subClassOf biolink:OrganismTaxonToEnvironmentAssociation ;
    owl:onProperty biolink:category ;
    owl:someValuesFrom biolink:OrganismTaxonToEnvironmentAssociation .

[] a owl:Restriction ;
    rdfs:subClassOf biolink:DiseaseToPhenotypicFeatureAssociation ;
    owl:onProperty biolink:category ;
    owl:someValuesFrom biolink:DiseaseToPhenotypicFeatureAssociation .

[] a owl:Restriction ;
    rdfs:subClassOf biolink:AnatomicalEntityHasPartAnatomicalEntityAssociation ;
    owl:onProperty biolink:category ;
    owl:someValuesFrom biolink:AnatomicalEntityHasPartAnatomicalEntityAssociation .

[] a owl:Restriction ;
    rdfs:subClassOf biolink:ChemicalEntityToPathwayAssociation ;
    owl:onProperty biolink:category ;
    owl:someValuesFrom biolink:ChemicalEntityToPathwayAssociation .

[] a owl:Restriction ;
    rdfs:subClassOf biolink:PhenotypicFeature ;
    owl:onProperty biolink:category ;
    owl:someValuesFrom biolink:PhenotypicFeature .

[] a owl:Restriction ;
    rdfs:subClassOf biolink:ChemicalExposure ;
    owl:onProperty biolink:category ;
    owl:someValuesFrom biolink:ChemicalExposure .

[] a owl:Restriction ;
    rdfs:subClassOf biolink:GeographicExposure ;
    owl:onProperty biolink:category ;
    owl:someValuesFrom biolink:GeographicExposure .

[] a owl:Restriction ;
    rdfs:subClassOf biolink:SocioeconomicExposure ;
    owl:onProperty biolink:category ;
    owl:someValuesFrom biolink:SocioeconomicExposure .

[] a owl:Restriction ;
    rdfs:subClassOf biolink:CellLine ;
    owl:onProperty biolink:category ;
    owl:someValuesFrom biolink:CellLine .

[] a owl:Restriction ;
    rdfs:subClassOf biolink:ClinicalIntervention ;
    owl:onProperty biolink:category ;
    owl:someValuesFrom biolink:ClinicalIntervention .

[] a owl:Restriction ;
    rdfs:subClassOf biolink:AnatomicalEntity ;
    owl:onProperty biolink:category ;
    owl:someValuesFrom biolink:AnatomicalEntity .

[] a owl:Restriction ;
    rdfs:subClassOf biolink:NucleicAcidEntity ;
    owl:onProperty biolink:category ;
    owl:someValuesFrom biolink:NucleicAcidEntity .

[] a owl:Restriction ;
    rdfs:subClassOf biolink:RetrievalSource ;
    owl:onProperty biolink:category ;
    owl:someValuesFrom biolink:RetrievalSource .

[] a owl:Restriction ;
    rdfs:subClassOf biolink:BiologicalSex ;
    owl:onProperty biolink:category ;
    owl:someValuesFrom biolink:BiologicalSex .

[] a owl:Restriction ;
    rdfs:subClassOf biolink:DatasetDistribution ;
    owl:onProperty biolink:category ;
    owl:someValuesFrom biolink:DatasetDistribution .

[] a owl:Restriction ;
    rdfs:subClassOf biolink:ChemicalOrDrugOrTreatmentSideEffectAssociation ;
    owl:onProperty biolink:category ;
    owl:someValuesFrom biolink:ChemicalOrDrugOrTreatmentSideEffectAssociation .

[] a owl:Restriction ;
    rdfs:subClassOf biolink:DrugExposure ;
    owl:onProperty biolink:category ;
    owl:someValuesFrom biolink:DrugExposure .

[] a owl:Restriction ;
    rdfs:subClassOf biolink:ComplexMolecularMixture ;
    owl:onProperty biolink:category ;
    owl:someValuesFrom biolink:ComplexMolecularMixture .

[] a owl:Restriction ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:allValuesFrom biolink:OrganismTaxon ;
            owl:onProperty biolink:in_taxon ],
        [ a owl:Restriction ;
            owl:minCardinality 0 ;
            owl:onProperty biolink:in_taxon ],
        [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:in_taxon ],
        [ a owl:Restriction ;
            owl:minCardinality 0 ;
            owl:onProperty biolink:in_taxon_label ],
        [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:in_taxon_label ],
        [ a owl:Restriction ;
            owl:allValuesFrom xsd:string ;
            owl:onProperty biolink:in_taxon_label ] ;
    owl:onProperty linkml:mixins ;
    owl:someValuesFrom biolink:ThingWithTaxon .

[] a owl:Restriction ;
    rdfs:subClassOf biolink:Virus ;
    owl:onProperty biolink:category ;
    owl:someValuesFrom biolink:Virus .

[] a owl:Restriction ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:minCardinality 0 ;
            owl:onProperty biolink:object_direction_qualifier ],
        [ a owl:Restriction ;
            owl:allValuesFrom xsd:anyURI ;
            owl:onProperty biolink:qualified_predicate ],
        [ a owl:Restriction ;
            owl:minCardinality 0 ;
            owl:onProperty biolink:qualified_predicate ],
        [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:qualified_predicate ],
        [ a owl:Restriction ;
            owl:allValuesFrom biolink:GeneOrGeneProductOrChemicalEntityAspectEnum ;
            owl:onProperty biolink:object_aspect_qualifier ],
        [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:object_aspect_qualifier ],
        [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:subject_direction_qualifier ],
        [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:object_direction_qualifier ],
        [ a owl:Restriction ;
            owl:allValuesFrom biolink:DirectionQualifierEnum ;
            owl:onProperty biolink:object_direction_qualifier ],
        [ a owl:Restriction ;
            owl:minCardinality 0 ;
            owl:onProperty biolink:object_aspect_qualifier ],
        [ a owl:Restriction ;
            owl:minCardinality 0 ;
            owl:onProperty biolink:subject_direction_qualifier ],
        [ a owl:Restriction ;
            owl:minCardinality 0 ;
            owl:onProperty biolink:subject_aspect_qualifier ],
        [ a owl:Restriction ;
            owl:allValuesFrom biolink:DirectionQualifierEnum ;
            owl:onProperty biolink:subject_direction_qualifier ],
        [ a owl:Restriction ;
            owl:allValuesFrom biolink:GeneOrGeneProductOrChemicalEntityAspectEnum ;
            owl:onProperty biolink:subject_aspect_qualifier ],
        [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:subject_aspect_qualifier ] ;
    owl:onProperty linkml:mixins ;
    owl:someValuesFrom biolink:EntityToFeatureOrGeneQualifiersMixin .

[] a owl:Restriction ;
    rdfs:subClassOf biolink:ProteinIsoform ;
    owl:onProperty biolink:category ;
    owl:someValuesFrom biolink:ProteinIsoform .

[] a owl:Restriction ;
    rdfs:subClassOf biolink:NamedThing ;
    owl:onProperty biolink:category ;
    owl:someValuesFrom biolink:NamedThing .

[] a owl:Restriction ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:object ],
        [ a owl:Restriction ;
            owl:allValuesFrom biolink:Genotype ;
            owl:onProperty biolink:subject ],
        [ a owl:Restriction ;
            owl:minCardinality 1 ;
            owl:onProperty biolink:predicate ],
        [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:predicate ],
        [ a owl:Restriction ;
            owl:minCardinality 1 ;
            owl:onProperty biolink:subject ],
        [ a owl:Restriction ;
            owl:minCardinality 1 ;
            owl:onProperty biolink:object ],
        [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:subject ],
        [ a owl:Restriction ;
            owl:allValuesFrom biolink:NamedThing ;
            owl:onProperty biolink:object ],
        [ a owl:Restriction ;
            owl:allValuesFrom xsd:anyURI ;
            owl:onProperty biolink:predicate ] ;
    owl:onProperty linkml:mixins ;
    owl:someValuesFrom biolink:GenotypeToEntityAssociationMixin .

[] a owl:Restriction ;
    rdfs:subClassOf biolink:ClinicalCourse ;
    owl:onProperty biolink:category ;
    owl:someValuesFrom biolink:ClinicalCourse .

[] a owl:Restriction ;
    rdfs:subClassOf biolink:MacromolecularMachineToBiologicalProcessAssociation ;
    owl:onProperty biolink:category ;
    owl:someValuesFrom biolink:MacromolecularMachineToBiologicalProcessAssociation .

[] a owl:Restriction ;
    rdfs:subClassOf biolink:Vertebrate ;
    owl:onProperty biolink:category ;
    owl:someValuesFrom biolink:Vertebrate .

[] a owl:Restriction ;
    rdfs:subClassOf biolink:ChiSquaredAnalysisResult ;
    owl:onProperty biolink:category ;
    owl:someValuesFrom biolink:ChiSquaredAnalysisResult .

[] a owl:Restriction ;
    rdfs:subClassOf biolink:PathologicalProcessExposure ;
    owl:onProperty biolink:category ;
    owl:someValuesFrom biolink:PathologicalProcessExposure .

[] a owl:Restriction ;
    rdfs:subClassOf biolink:InformationContentEntity ;
    owl:onProperty biolink:category ;
    owl:someValuesFrom biolink:InformationContentEntity .

[] a owl:Restriction ;
    rdfs:subClassOf biolink:Cell ;
    owl:onProperty biolink:category ;
    owl:someValuesFrom biolink:Cell .

[] a owl:Restriction ;
    rdfs:subClassOf biolink:ChemicalEntityToDiseaseOrPhenotypicFeatureAssociation ;
    owl:onProperty biolink:category ;
    owl:someValuesFrom biolink:ChemicalEntityToDiseaseOrPhenotypicFeatureAssociation .

[] a owl:Restriction ;
    rdfs:subClassOf biolink:DiseaseAssociatedWithResponseToChemicalEntityAssociation ;
    owl:onProperty biolink:category ;
    owl:someValuesFrom biolink:DiseaseAssociatedWithResponseToChemicalEntityAssociation .

[] a owl:Restriction ;
    rdfs:subClassOf biolink:GeneToGeneFamilyAssociation ;
    owl:onProperty biolink:category ;
    owl:someValuesFrom biolink:GeneToGeneFamilyAssociation .

[] a owl:Restriction ;
    rdfs:subClassOf biolink:EnvironmentalFoodContaminant ;
    owl:onProperty biolink:category ;
    owl:someValuesFrom biolink:EnvironmentalFoodContaminant .

[] a owl:Restriction ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:predicate ],
        [ a owl:Restriction ;
            owl:minCardinality 1 ;
            owl:onProperty biolink:subject ],
        [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:subject ],
        [ a owl:Restriction ;
            owl:minCardinality 1 ;
            owl:onProperty biolink:object ],
        [ a owl:Restriction ;
            owl:minCardinality 1 ;
            owl:onProperty biolink:predicate ],
        [ a owl:Restriction ;
            owl:allValuesFrom biolink:NamedThing ;
            owl:onProperty biolink:object ],
        [ a owl:Restriction ;
            owl:allValuesFrom xsd:anyURI ;
            owl:onProperty biolink:predicate ],
        [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:object ],
        [ a owl:Restriction ;
            owl:allValuesFrom biolink:OrganismTaxon ;
            owl:onProperty biolink:subject ] ;
    owl:onProperty linkml:mixins ;
    owl:someValuesFrom biolink:OrganismTaxonToEntityAssociation .

[] a owl:Restriction ;
    rdfs:subClassOf biolink:Association ;
    owl:onProperty biolink:category ;
    owl:someValuesFrom biolink:Association .

[] a owl:Restriction ;
    rdfs:subClassOf biolink:SiRNA ;
    owl:onProperty biolink:category ;
    owl:someValuesFrom biolink:SiRNA .

[] a owl:Restriction ;
    rdfs:subClassOf biolink:Drug ;
    owl:onProperty biolink:category ;
    owl:someValuesFrom biolink:Drug .

[] a owl:Restriction ;
    rdfs:subClassOf biolink:GeneAsAModelOfDiseaseAssociation ;
    owl:onProperty biolink:category ;
    owl:someValuesFrom biolink:GeneAsAModelOfDiseaseAssociation .

[] a owl:Restriction ;
    rdfs:subClassOf biolink:CaseToGeneAssociation ;
    owl:onProperty biolink:category ;
    owl:someValuesFrom biolink:CaseToGeneAssociation .

[] a owl:Restriction ;
    rdfs:subClassOf biolink:SeverityValue ;
    owl:onProperty biolink:category ;
    owl:someValuesFrom biolink:SeverityValue .

[] a owl:Restriction ;
    owl:onProperty linkml:mixins ;
    owl:someValuesFrom biolink:SubjectOfInvestigation .

[] a owl:Restriction ;
    rdfs:subClassOf biolink:Agent ;
    owl:onProperty biolink:category ;
    owl:someValuesFrom biolink:Agent .

[] a owl:Restriction ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:predicate ],
        [ a owl:Restriction ;
            owl:minCardinality 1 ;
            owl:onProperty biolink:object ],
        [ a owl:Restriction ;
            owl:minCardinality 1 ;
            owl:onProperty biolink:predicate ],
        [ a owl:Restriction ;
            owl:minCardinality 1 ;
            owl:onProperty biolink:subject ],
        [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:subject ],
        [ a owl:Restriction ;
            owl:allValuesFrom biolink:ChemicalEntityOrGeneOrGeneProduct ;
            owl:onProperty biolink:subject ],
        [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:object ],
        [ a owl:Restriction ;
            owl:allValuesFrom biolink:NamedThing ;
            owl:onProperty biolink:object ],
        [ a owl:Restriction ;
            owl:allValuesFrom xsd:anyURI ;
            owl:onProperty biolink:predicate ] ;
    owl:onProperty linkml:mixins ;
    owl:someValuesFrom biolink:ChemicalToEntityAssociationMixin .

[] a owl:Restriction ;
    rdfs:subClassOf biolink:GenotypeToGeneAssociation ;
    owl:onProperty biolink:category ;
    owl:someValuesFrom biolink:GenotypeToGeneAssociation .

[] a owl:Restriction ;
    rdfs:subClassOf biolink:PhenotypicFeatureToPhenotypicFeatureAssociation ;
    owl:onProperty biolink:category ;
    owl:someValuesFrom biolink:PhenotypicFeatureToPhenotypicFeatureAssociation .

[] a owl:Restriction ;
    rdfs:subClassOf biolink:GeneAffectsChemicalAssociation ;
    owl:onProperty biolink:category ;
    owl:someValuesFrom biolink:GeneAffectsChemicalAssociation .

[] a owl:Restriction ;
    rdfs:subClassOf biolink:GenotypeToVariantAssociation ;
    owl:onProperty biolink:category ;
    owl:someValuesFrom biolink:GenotypeToVariantAssociation .

[] a owl:Restriction ;
    rdfs:subClassOf biolink:BioticExposure ;
    owl:onProperty biolink:category ;
    owl:someValuesFrom biolink:BioticExposure .

[] a owl:Restriction ;
    rdfs:subClassOf biolink:OrganismalEntity ;
    owl:onProperty biolink:category ;
    owl:someValuesFrom biolink:OrganismalEntity .

[] a owl:Restriction ;
    rdfs:subClassOf biolink:EnvironmentalExposure ;
    owl:onProperty biolink:category ;
    owl:someValuesFrom biolink:EnvironmentalExposure .

[] a owl:Restriction ;
    rdfs:subClassOf biolink:BiologicalProcessOrActivityToBiologicalProcessOrActivityAssociation ;
    owl:onProperty biolink:category ;
    owl:someValuesFrom biolink:BiologicalProcessOrActivityToBiologicalProcessOrActivityAssociation .

[] a owl:Restriction ;
    rdfs:subClassOf biolink:MolecularMixture ;
    owl:onProperty biolink:category ;
    owl:someValuesFrom biolink:MolecularMixture .

[] a owl:Restriction ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:allValuesFrom xsd:string ;
            owl:onProperty biolink:id ],
        [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:id ],
        [ a owl:Restriction ;
            owl:minCardinality 0 ;
            owl:onProperty biolink:subsets ],
        [ a owl:Restriction ;
            owl:minCardinality 1 ;
            owl:onProperty biolink:id ],
        [ a owl:Restriction ;
            owl:allValuesFrom xsd:string ;
            owl:onProperty biolink:subsets ] ;
    owl:onProperty linkml:mixins ;
    owl:someValuesFrom biolink:OntologyClass .

[] a owl:Restriction ;
    rdfs:subClassOf biolink:MolecularActivityToPathwayAssociation ;
    owl:onProperty biolink:category ;
    owl:someValuesFrom biolink:MolecularActivityToPathwayAssociation .

[] a owl:Restriction ;
    rdfs:subClassOf biolink:OrganismTaxonToOrganismTaxonInteraction ;
    owl:onProperty biolink:category ;
    owl:someValuesFrom biolink:OrganismTaxonToOrganismTaxonInteraction .

[] a owl:Restriction ;
    rdfs:subClassOf biolink:Pathway ;
    owl:onProperty biolink:category ;
    owl:someValuesFrom biolink:Pathway .

[] a owl:Restriction ;
    rdfs:subClassOf biolink:PhysicalEntity ;
    owl:onProperty biolink:category ;
    owl:someValuesFrom biolink:PhysicalEntity .

[] a owl:Restriction ;
    rdfs:subClassOf biolink:Evidence ;
    owl:onProperty biolink:category ;
    owl:someValuesFrom biolink:Evidence .

[] a owl:Restriction ;
    rdfs:subClassOf biolink:GenotypeAsAModelOfDiseaseAssociation ;
    owl:onProperty biolink:category ;
    owl:someValuesFrom biolink:GenotypeAsAModelOfDiseaseAssociation .

[] a owl:Restriction ;
    rdfs:subClassOf biolink:AnatomicalEntityPartOfAnatomicalEntityAssociation ;
    owl:onProperty biolink:category ;
    owl:someValuesFrom biolink:AnatomicalEntityPartOfAnatomicalEntityAssociation .

[] a owl:Restriction ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:predicate ],
        [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:object ],
        [ a owl:Restriction ;
            owl:minCardinality 1 ;
            owl:onProperty biolink:object ],
        [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:subject ],
        [ a owl:Restriction ;
            owl:allValuesFrom xsd:anyURI ;
            owl:onProperty biolink:predicate ],
        [ a owl:Restriction ;
            owl:allValuesFrom biolink:ExposureEvent ;
            owl:onProperty biolink:object ],
        [ a owl:Restriction ;
            owl:allValuesFrom biolink:NamedThing ;
            owl:onProperty biolink:subject ],
        [ a owl:Restriction ;
            owl:minCardinality 1 ;
            owl:onProperty biolink:subject ],
        [ a owl:Restriction ;
            owl:minCardinality 1 ;
            owl:onProperty biolink:predicate ] ;
    owl:onProperty linkml:mixins ;
    owl:someValuesFrom biolink:EntityToExposureEventAssociationMixin .

[] a owl:Restriction ;
    rdfs:subClassOf biolink:RelativeFrequencyAnalysisResult ;
    owl:onProperty biolink:category ;
    owl:someValuesFrom biolink:RelativeFrequencyAnalysisResult .

[] a owl:Restriction ;
    rdfs:subClassOf biolink:GeneHasVariantThatContributesToDiseaseAssociation ;
    owl:onProperty biolink:category ;
    owl:someValuesFrom biolink:GeneHasVariantThatContributesToDiseaseAssociation .

[] a owl:Restriction ;
    rdfs:subClassOf biolink:StudyPopulation ;
    owl:onProperty biolink:category ;
    owl:someValuesFrom biolink:StudyPopulation .

[] a owl:Restriction ;
    rdfs:subClassOf biolink:TranscriptionFactorBindingSite ;
    owl:onProperty biolink:category ;
    owl:someValuesFrom biolink:TranscriptionFactorBindingSite .

[] a owl:Restriction ;
    rdfs:subClassOf biolink:BehavioralFeature ;
    owl:onProperty biolink:category ;
    owl:someValuesFrom biolink:BehavioralFeature .

[] a owl:Restriction ;
    rdfs:subClassOf biolink:ChemicalEntityToChemicalEntityAssociation ;
    owl:onProperty biolink:category ;
    owl:someValuesFrom biolink:ChemicalEntityToChemicalEntityAssociation .

[] a owl:Restriction ;
    rdfs:subClassOf biolink:GeneticInheritance ;
    owl:onProperty biolink:category ;
    owl:someValuesFrom biolink:GeneticInheritance .

[] a owl:Restriction ;
    rdfs:subClassOf biolink:PathologicalProcess ;
    owl:onProperty biolink:category ;
    owl:someValuesFrom biolink:PathologicalProcess .

[] a owl:Restriction ;
    rdfs:subClassOf biolink:CorrelatedGeneToDiseaseAssociation ;
    owl:onProperty biolink:category ;
    owl:someValuesFrom biolink:CorrelatedGeneToDiseaseAssociation .

[] a owl:Restriction ;
    rdfs:subClassOf biolink:Fungus ;
    owl:onProperty biolink:category ;
    owl:someValuesFrom biolink:Fungus .

[] a owl:Restriction ;
    rdfs:subClassOf biolink:VariantToGeneAssociation ;
    owl:onProperty biolink:category ;
    owl:someValuesFrom biolink:VariantToGeneAssociation .

[] a owl:Restriction ;
    rdfs:subClassOf biolink:MaterialSampleDerivationAssociation ;
    owl:onProperty biolink:category ;
    owl:someValuesFrom biolink:MaterialSampleDerivationAssociation .

[] a owl:Restriction ;
    rdfs:subClassOf biolink:ChemicalEntity ;
    owl:onProperty biolink:category ;
    owl:someValuesFrom biolink:ChemicalEntity .

[] a owl:Restriction ;
    rdfs:subClassOf biolink:DrugToGeneAssociation ;
    owl:onProperty biolink:category ;
    owl:someValuesFrom biolink:DrugToGeneAssociation .

[] a owl:Restriction ;
    rdfs:subClassOf biolink:WebPage ;
    owl:onProperty biolink:category ;
    owl:someValuesFrom biolink:WebPage .

[] a owl:Restriction ;
    rdfs:subClassOf biolink:GeneFamily ;
    owl:onProperty biolink:category ;
    owl:someValuesFrom biolink:GeneFamily .

[] a owl:Restriction ;
    rdfs:subClassOf biolink:IceesStudyResult ;
    owl:onProperty biolink:category ;
    owl:someValuesFrom biolink:IceesStudyResult .

[] a owl:Restriction ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:minCardinality 1 ;
            owl:onProperty biolink:subject ],
        [ a owl:Restriction ;
            owl:minCardinality 1 ;
            owl:onProperty biolink:predicate ],
        [ a owl:Restriction ;
            owl:allValuesFrom biolink:NamedThing ;
            owl:onProperty biolink:object ],
        [ a owl:Restriction ;
            owl:allValuesFrom biolink:CellLine ;
            owl:onProperty biolink:subject ],
        [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:object ],
        [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:predicate ],
        [ a owl:Restriction ;
            owl:minCardinality 1 ;
            owl:onProperty biolink:object ],
        [ a owl:Restriction ;
            owl:allValuesFrom xsd:anyURI ;
            owl:onProperty biolink:predicate ],
        [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:subject ] ;
    owl:onProperty linkml:mixins ;
    owl:someValuesFrom biolink:CellLineToEntityAssociationMixin .

[] a owl:Restriction ;
    rdfs:subClassOf biolink:ClinicalFinding ;
    owl:onProperty biolink:category ;
    owl:someValuesFrom biolink:ClinicalFinding .

[] a owl:Restriction ;
    owl:onProperty linkml:mixins ;
    owl:someValuesFrom biolink:PhysicalEssenceOrOccurrent .

[] rdfs:subClassOf [ owl:unionOf ( [ a owl:Restriction ;
                        owl:allValuesFrom xsd:string ;
                        owl:onProperty biolink:p_value ] [ a owl:Restriction ;
                        owl:allValuesFrom xsd:string ;
                        owl:onProperty biolink:adjusted_p_value ] ) ] ;
    owl:intersectionOf ( [ a owl:Restriction ;
                owl:onProperty biolink:statistical_significance_qualifier ;
                owl:someValuesFrom xsd:string ] biolink:Association ) .

[] a owl:Restriction ;
    rdfs:subClassOf biolink:FunctionalAssociation ;
    owl:onProperty biolink:category ;
    owl:someValuesFrom biolink:FunctionalAssociation .

[] a owl:Restriction ;
    rdfs:subClassOf biolink:OrganismalEntityAsAModelOfDiseaseAssociation ;
    owl:onProperty biolink:category ;
    owl:someValuesFrom biolink:OrganismalEntityAsAModelOfDiseaseAssociation .

[] a owl:Restriction ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:subject_aspect_qualifier ],
        [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:object_direction_qualifier ],
        [ a owl:Restriction ;
            owl:minCardinality 0 ;
            owl:onProperty biolink:subject_aspect_qualifier ],
        [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:subject_direction_qualifier ],
        [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:object_aspect_qualifier ],
        [ a owl:Restriction ;
            owl:minCardinality 0 ;
            owl:onProperty biolink:object_direction_qualifier ],
        [ a owl:Restriction ;
            owl:allValuesFrom biolink:DirectionQualifierEnum ;
            owl:onProperty biolink:subject_direction_qualifier ],
        [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:qualified_predicate ],
        [ a owl:Restriction ;
            owl:minCardinality 0 ;
            owl:onProperty biolink:qualified_predicate ],
        [ a owl:Restriction ;
            owl:minCardinality 0 ;
            owl:onProperty biolink:subject_direction_qualifier ],
        [ a owl:Restriction ;
            owl:allValuesFrom xsd:anyURI ;
            owl:onProperty biolink:qualified_predicate ],
        [ a owl:Restriction ;
            owl:allValuesFrom biolink:GeneOrGeneProductOrChemicalEntityAspectEnum ;
            owl:onProperty biolink:object_aspect_qualifier ],
        [ a owl:Restriction ;
            owl:allValuesFrom biolink:DirectionQualifierEnum ;
            owl:onProperty biolink:object_direction_qualifier ],
        [ a owl:Restriction ;
            owl:minCardinality 0 ;
            owl:onProperty biolink:object_aspect_qualifier ],
        [ a owl:Restriction ;
            owl:allValuesFrom biolink:GeneOrGeneProductOrChemicalEntityAspectEnum ;
            owl:onProperty biolink:subject_aspect_qualifier ] ;
    owl:onProperty linkml:mixins ;
    owl:someValuesFrom biolink:FeatureOrDiseaseQualifiersToEntityMixin .

[] a owl:Restriction ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:allValuesFrom xsd:anyURI ;
            owl:onProperty biolink:qualified_predicate ],
        [ a owl:Restriction ;
            owl:minCardinality 0 ;
            owl:onProperty biolink:qualified_predicate ],
        [ a owl:Restriction ;
            owl:allValuesFrom biolink:GeneOrGeneProductOrChemicalEntityAspectEnum ;
            owl:onProperty biolink:subject_aspect_qualifier ],
        [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:object_direction_qualifier ],
        [ a owl:Restriction ;
            owl:allValuesFrom biolink:DirectionQualifierEnum ;
            owl:onProperty biolink:subject_direction_qualifier ],
        [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:subject_direction_qualifier ],
        [ a owl:Restriction ;
            owl:minCardinality 0 ;
            owl:onProperty biolink:subject_direction_qualifier ],
        [ a owl:Restriction ;
            owl:allValuesFrom biolink:DirectionQualifierEnum ;
            owl:onProperty biolink:object_direction_qualifier ],
        [ a owl:Restriction ;
            owl:minCardinality 0 ;
            owl:onProperty biolink:object_aspect_qualifier ],
        [ a owl:Restriction ;
            owl:allValuesFrom biolink:GeneOrGeneProductOrChemicalEntityAspectEnum ;
            owl:onProperty biolink:object_aspect_qualifier ],
        [ a owl:Restriction ;
            owl:minCardinality 0 ;
            owl:onProperty biolink:object_direction_qualifier ],
        [ a owl:Restriction ;
            owl:minCardinality 0 ;
            owl:onProperty biolink:subject_aspect_qualifier ],
        [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:object_aspect_qualifier ],
        [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:qualified_predicate ],
        [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:subject_aspect_qualifier ] ;
    owl:onProperty linkml:mixins ;
    owl:someValuesFrom biolink:EntityToFeatureOrVariantQualifiersMixin .

[] a owl:Restriction ;
    rdfs:subClassOf biolink:GeneToPathwayAssociation ;
    owl:onProperty biolink:category ;
    owl:someValuesFrom biolink:GeneToPathwayAssociation .

[] a owl:Restriction ;
    rdfs:subClassOf biolink:FoodAdditive ;
    owl:onProperty biolink:category ;
    owl:someValuesFrom biolink:FoodAdditive .

[] a owl:Restriction ;
    rdfs:subClassOf biolink:ProteinFamily ;
    owl:onProperty biolink:category ;
    owl:someValuesFrom biolink:ProteinFamily .

[] a owl:Restriction ;
    rdfs:subClassOf biolink:Event ;
    owl:onProperty biolink:category ;
    owl:someValuesFrom biolink:Event .

[] a owl:Restriction ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:allValuesFrom biolink:DiseaseOrPhenotypicFeature ;
            owl:onProperty biolink:object ],
        [ a owl:Restriction ;
            owl:allValuesFrom biolink:DirectionQualifierEnum ;
            owl:onProperty biolink:object_direction_qualifier ],
        [ a owl:Restriction ;
            owl:allValuesFrom biolink:Disease ;
            owl:onProperty biolink:disease_context_qualifier ],
        [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:object_specialization_qualifier ],
        [ a owl:Restriction ;
            owl:minCardinality 0 ;
            owl:onProperty biolink:subject_specialization_qualifier ],
        [ a owl:Restriction ;
            owl:minCardinality 0 ;
            owl:onProperty biolink:population_context_qualifier ],
        [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:disease_context_qualifier ],
        [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:subject_aspect_qualifier ],
        [ a owl:Restriction ;
            owl:allValuesFrom xsd:anyURI ;
            owl:onProperty biolink:qualified_predicate ],
        [ a owl:Restriction ;
            owl:allValuesFrom xsd:string ;
            owl:onProperty biolink:anatomical_context_qualifier ],
        [ a owl:Restriction ;
            owl:minCardinality 0 ;
            owl:onProperty biolink:anatomical_context_qualifier ],
        [ a owl:Restriction ;
            owl:minCardinality 0 ;
            owl:onProperty biolink:object_specialization_qualifier ],
        [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:object_direction_qualifier ],
        [ a owl:Restriction ;
            owl:minCardinality 0 ;
            owl:onProperty biolink:object_aspect_qualifier ],
        [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:object ],
        [ a owl:Restriction ;
            owl:allValuesFrom biolink:DirectionQualifierEnum ;
            owl:onProperty biolink:subject_direction_qualifier ],
        [ a owl:Restriction ;
            owl:minCardinality 0 ;
            owl:onProperty biolink:subject_aspect_qualifier ],
        [ a owl:Restriction ;
            owl:allValuesFrom xsd:anyURI ;
            owl:onProperty biolink:object_specialization_qualifier ],
        [ a owl:Restriction ;
            owl:minCardinality 0 ;
            owl:onProperty biolink:disease_context_qualifier ],
        [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:population_context_qualifier ],
        [ a owl:Restriction ;
            owl:minCardinality 1 ;
            owl:onProperty biolink:object ],
        [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:object_aspect_qualifier ],
        [ a owl:Restriction ;
            owl:allValuesFrom biolink:PopulationOfIndividualOrganisms ;
            owl:onProperty biolink:population_context_qualifier ],
        [ a owl:Restriction ;
            owl:allValuesFrom xsd:anyURI ;
            owl:onProperty biolink:subject_specialization_qualifier ],
        [ a owl:Restriction ;
            owl:allValuesFrom biolink:GeneOrGeneProductOrChemicalEntityAspectEnum ;
            owl:onProperty biolink:object_aspect_qualifier ],
        [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:subject_direction_qualifier ],
        [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:qualified_predicate ],
        [ a owl:Restriction ;
            owl:minCardinality 0 ;
            owl:onProperty biolink:object_direction_qualifier ],
        [ a owl:Restriction ;
            owl:minCardinality 0 ;
            owl:onProperty biolink:subject_direction_qualifier ],
        [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:subject_specialization_qualifier ],
        [ a owl:Restriction ;
            owl:allValuesFrom biolink:GeneOrGeneProductOrChemicalEntityAspectEnum ;
            owl:onProperty biolink:subject_aspect_qualifier ],
        [ a owl:Restriction ;
            owl:minCardinality 0 ;
            owl:onProperty biolink:qualified_predicate ] ;
    owl:onProperty linkml:mixins ;
    owl:someValuesFrom biolink:EntityToDiseaseOrPhenotypicFeatureAssociationMixin .

[] a owl:Restriction ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:minCardinality 0 ;
            owl:onProperty biolink:sex_qualifier ],
        [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:sex_qualifier ],
        [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:object ],
        [ a owl:Restriction ;
            owl:minCardinality 1 ;
            owl:onProperty biolink:object ],
        [ a owl:Restriction ;
            owl:allValuesFrom biolink:BiologicalSex ;
            owl:onProperty biolink:sex_qualifier ],
        [ a owl:Restriction ;
            owl:allValuesFrom biolink:PhenotypicFeature ;
            owl:onProperty biolink:object ] ;
    owl:onProperty linkml:mixins ;
    owl:someValuesFrom biolink:EntityToPhenotypicFeatureAssociationMixin .

[] a owl:Restriction ;
    rdfs:subClassOf biolink:SequenceVariantModulatesTreatmentAssociation ;
    owl:onProperty biolink:category ;
    owl:someValuesFrom biolink:SequenceVariantModulatesTreatmentAssociation .

[] a owl:Restriction ;
    rdfs:subClassOf biolink:GeneToGeneAssociation ;
    owl:onProperty biolink:category ;
    owl:someValuesFrom biolink:GeneToGeneAssociation .

[] a owl:Restriction ;
    rdfs:subClassOf biolink:MacromolecularComplex ;
    owl:onProperty biolink:category ;
    owl:someValuesFrom biolink:MacromolecularComplex .

[] a owl:Restriction ;
    rdfs:subClassOf biolink:VariantToPhenotypicFeatureAssociation ;
    owl:onProperty biolink:category ;
    owl:someValuesFrom biolink:VariantToPhenotypicFeatureAssociation .

[] a owl:Restriction ;
    rdfs:subClassOf biolink:DatasetSummary ;
    owl:onProperty biolink:category ;
    owl:someValuesFrom biolink:DatasetSummary .

[] a owl:Restriction ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:minCardinality 0 ;
            owl:onProperty biolink:has_count ],
        [ a owl:Restriction ;
            owl:allValuesFrom xsd:double ;
            owl:onProperty biolink:has_percentage ],
        [ a owl:Restriction ;
            owl:allValuesFrom xsd:integer ;
            owl:onProperty biolink:has_count ],
        [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:has_total ],
        [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:has_percentage ],
        [ a owl:Restriction ;
            owl:minCardinality 0 ;
            owl:onProperty biolink:has_percentage ],
        [ a owl:Restriction ;
            owl:minCardinality 0 ;
            owl:onProperty biolink:has_total ],
        [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:has_quotient ],
        [ a owl:Restriction ;
            owl:minCardinality 0 ;
            owl:onProperty biolink:has_quotient ],
        [ a owl:Restriction ;
            owl:allValuesFrom xsd:integer ;
            owl:onProperty biolink:has_total ],
        [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:has_count ],
        [ a owl:Restriction ;
            owl:allValuesFrom xsd:double ;
            owl:onProperty biolink:has_quotient ] ;
    owl:onProperty linkml:mixins ;
    owl:someValuesFrom biolink:FrequencyQuantifier .

[] a owl:Restriction ;
    rdfs:subClassOf biolink:MolecularEntity ;
    owl:onProperty biolink:category ;
    owl:someValuesFrom biolink:MolecularEntity .

[] a owl:Restriction ;
    rdfs:subClassOf biolink:EntityToDiseaseAssociation ;
    owl:onProperty biolink:category ;
    owl:someValuesFrom biolink:EntityToDiseaseAssociation .

[] a owl:Restriction ;
    rdfs:subClassOf biolink:MolecularActivity ;
    owl:onProperty biolink:category ;
    owl:someValuesFrom biolink:MolecularActivity .

[] a owl:Restriction ;
    rdfs:subClassOf biolink:GeneRegulatesGeneAssociation ;
    owl:onProperty biolink:category ;
    owl:someValuesFrom biolink:GeneRegulatesGeneAssociation .

[] a owl:Restriction ;
    rdfs:subClassOf biolink:TranscriptToGeneRelationship ;
    owl:onProperty biolink:category ;
    owl:someValuesFrom biolink:TranscriptToGeneRelationship .

[] a owl:Restriction ;
    rdfs:subClassOf biolink:Study ;
    owl:onProperty biolink:category ;
    owl:someValuesFrom biolink:Study .

[] a owl:Restriction ;
    rdfs:subClassOf biolink:PlanetaryEntity ;
    owl:onProperty biolink:category ;
    owl:someValuesFrom biolink:PlanetaryEntity .

[] a owl:Restriction ;
    owl:onProperty linkml:mixins ;
    owl:someValuesFrom biolink:RelationshipQuantifier .

[] a owl:Restriction ;
    rdfs:subClassOf biolink:DiseaseOrPhenotypicFeatureExposure ;
    owl:onProperty biolink:category ;
    owl:someValuesFrom biolink:DiseaseOrPhenotypicFeatureExposure .

[] a owl:Restriction ;
    rdfs:subClassOf biolink:CommonDataElement ;
    owl:onProperty biolink:category ;
    owl:someValuesFrom biolink:CommonDataElement .

[] a owl:Restriction ;
    rdfs:subClassOf biolink:ReagentTargetedGene ;
    owl:onProperty biolink:category ;
    owl:someValuesFrom biolink:ReagentTargetedGene .

[] a owl:Restriction ;
    rdfs:subClassOf biolink:MacromolecularMachineToCellularComponentAssociation ;
    owl:onProperty biolink:category ;
    owl:someValuesFrom biolink:MacromolecularMachineToCellularComponentAssociation .

[] a owl:Restriction ;
    rdfs:subClassOf biolink:SequenceAssociation ;
    owl:onProperty biolink:category ;
    owl:someValuesFrom biolink:SequenceAssociation .

[] a owl:Restriction ;
    rdfs:subClassOf biolink:Entity ;
    owl:onProperty biolink:category ;
    owl:someValuesFrom biolink:Entity .

[] a owl:Restriction ;
    rdfs:subClassOf biolink:ExonToTranscriptRelationship ;
    owl:onProperty biolink:category ;
    owl:someValuesFrom biolink:ExonToTranscriptRelationship .

[] a owl:Restriction ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:minCardinality 1 ;
            owl:onProperty biolink:subject ],
        [ a owl:Restriction ;
            owl:minCardinality 1 ;
            owl:onProperty biolink:predicate ],
        [ a owl:Restriction ;
            owl:allValuesFrom biolink:SequenceVariant ;
            owl:onProperty biolink:subject ],
        [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:subject ],
        [ a owl:Restriction ;
            owl:minCardinality 1 ;
            owl:onProperty biolink:object ],
        [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:object ],
        [ a owl:Restriction ;
            owl:allValuesFrom xsd:anyURI ;
            owl:onProperty biolink:predicate ],
        [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:predicate ],
        [ a owl:Restriction ;
            owl:allValuesFrom biolink:NamedThing ;
            owl:onProperty biolink:object ] ;
    owl:onProperty linkml:mixins ;
    owl:someValuesFrom biolink:VariantToEntityAssociationMixin .

[] a owl:Restriction ;
    rdfs:subClassOf biolink:Publication ;
    owl:onProperty biolink:category ;
    owl:someValuesFrom biolink:Publication .

[] a owl:Restriction ;
    rdfs:subClassOf biolink:AccessibleDnaRegion ;
    owl:onProperty biolink:category ;
    owl:someValuesFrom biolink:AccessibleDnaRegion .

[] a owl:Restriction ;
    rdfs:subClassOf biolink:SocioeconomicAttribute ;
    owl:onProperty biolink:category ;
    owl:someValuesFrom biolink:SocioeconomicAttribute .

[] a owl:Restriction ;
    rdfs:subClassOf biolink:RegulatoryRegion ;
    owl:onProperty biolink:category ;
    owl:someValuesFrom biolink:RegulatoryRegion .

[] a owl:Restriction ;
    owl:onProperty linkml:mixins ;
    owl:someValuesFrom biolink:PathognomonicityQuantifier .

[] a owl:Restriction ;
    rdfs:subClassOf biolink:SequenceVariant ;
    owl:onProperty biolink:category ;
    owl:someValuesFrom biolink:SequenceVariant .

[] a owl:Restriction ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:has_biological_sequence ],
        [ a owl:Restriction ;
            owl:allValuesFrom xsd:string ;
            owl:onProperty biolink:has_biological_sequence ],
        [ a owl:Restriction ;
            owl:minCardinality 0 ;
            owl:onProperty biolink:has_biological_sequence ] ;
    owl:onProperty linkml:mixins ;
    owl:someValuesFrom biolink:EpigenomicEntity .

[] a owl:Restriction ;
    rdfs:subClassOf biolink:VariantToDiseaseAssociation ;
    owl:onProperty biolink:category ;
    owl:someValuesFrom biolink:VariantToDiseaseAssociation .

[] a owl:Restriction ;
    rdfs:subClassOf biolink:OrganismTaxonToOrganismTaxonSpecialization ;
    owl:onProperty biolink:category ;
    owl:someValuesFrom biolink:OrganismTaxonToOrganismTaxonSpecialization .

[] a owl:Restriction ;
    rdfs:subClassOf biolink:Protein ;
    owl:onProperty biolink:category ;
    owl:someValuesFrom biolink:Protein .

[] a owl:Restriction ;
    rdfs:subClassOf biolink:Case ;
    owl:onProperty biolink:category ;
    owl:someValuesFrom biolink:Case .

[] a owl:Restriction ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:minCardinality 1 ;
            owl:onProperty biolink:object ],
        [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:object ],
        [ a owl:Restriction ;
            owl:allValuesFrom xsd:anyURI ;
            owl:onProperty biolink:predicate ],
        [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:predicate ],
        [ a owl:Restriction ;
            owl:minCardinality 1 ;
            owl:onProperty biolink:subject ],
        [ a owl:Restriction ;
            owl:allValuesFrom biolink:MaterialSample ;
            owl:onProperty biolink:subject ],
        [ a owl:Restriction ;
            owl:allValuesFrom biolink:NamedThing ;
            owl:onProperty biolink:object ],
        [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:subject ],
        [ a owl:Restriction ;
            owl:minCardinality 1 ;
            owl:onProperty biolink:predicate ] ;
    owl:onProperty linkml:mixins ;
    owl:someValuesFrom biolink:MaterialSampleToEntityAssociationMixin .

[] a owl:Restriction ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:allValuesFrom biolink:Gene ;
            owl:onProperty biolink:has_gene_or_gene_product ],
        [ a owl:Restriction ;
            owl:minCardinality 0 ;
            owl:onProperty biolink:has_gene_or_gene_product ] ;
    owl:onProperty linkml:mixins ;
    owl:someValuesFrom biolink:GeneGroupingMixin .

[] a owl:Restriction ;
    rdfs:subClassOf biolink:BiologicalProcessOrActivityToGeneOrGeneProductOrGeneFamilyAssociation ;
    owl:onProperty biolink:category ;
    owl:someValuesFrom biolink:BiologicalProcessOrActivityToGeneOrGeneProductOrGeneFamilyAssociation .

[] a owl:Restriction ;
    rdfs:subClassOf biolink:ReactionToCatalystAssociation ;
    owl:onProperty biolink:category ;
    owl:someValuesFrom biolink:ReactionToCatalystAssociation .

[] a owl:Restriction ;
    rdfs:subClassOf biolink:ChemicalAffectsGeneAssociation ;
    owl:onProperty biolink:category ;
    owl:someValuesFrom biolink:ChemicalAffectsGeneAssociation .

[] a owl:Restriction ;
    rdfs:subClassOf biolink:OrganismTaxonToOrganismTaxonAssociation ;
    owl:onProperty biolink:category ;
    owl:someValuesFrom biolink:OrganismTaxonToOrganismTaxonAssociation .

[] a owl:Restriction ;
    rdfs:subClassOf biolink:ChemicalEntityToChemicalDerivationAssociation ;
    owl:onProperty biolink:category ;
    owl:someValuesFrom biolink:ChemicalEntityToChemicalDerivationAssociation .

[] a owl:Restriction ;
    rdfs:subClassOf biolink:ChemicalEntityToAnatomicalEntityAssociation ;
    owl:onProperty biolink:category ;
    owl:someValuesFrom biolink:ChemicalEntityToAnatomicalEntityAssociation .

[] a owl:Restriction ;
    owl:onProperty linkml:mixins ;
    owl:someValuesFrom biolink:SpecificityQuantifier .

[] a owl:Restriction ;
    rdfs:subClassOf biolink:Serial ;
    owl:onProperty biolink:category ;
    owl:someValuesFrom biolink:Serial .

[] a owl:Restriction ;
    rdfs:subClassOf biolink:ObservedExpectedFrequencyAnalysisResult ;
    owl:onProperty biolink:category ;
    owl:someValuesFrom biolink:ObservedExpectedFrequencyAnalysisResult .

[] a owl:Restriction ;
    rdfs:subClassOf biolink:GeneToDiseaseAssociation ;
    owl:onProperty biolink:category ;
    owl:someValuesFrom biolink:GeneToDiseaseAssociation .

[] a owl:Restriction ;
    rdfs:subClassOf biolink:ChemicalMixture ;
    owl:onProperty biolink:category ;
    owl:someValuesFrom biolink:ChemicalMixture .

[] a owl:Restriction ;
    rdfs:subClassOf biolink:Food ;
    owl:onProperty biolink:category ;
    owl:someValuesFrom biolink:Food .

[] a owl:Restriction ;
    rdfs:subClassOf biolink:DrugLabel ;
    owl:onProperty biolink:category ;
    owl:someValuesFrom biolink:DrugLabel .

[] a owl:Restriction ;
    rdfs:subClassOf biolink:GenotypeToGenotypePartAssociation ;
    owl:onProperty biolink:category ;
    owl:someValuesFrom biolink:GenotypeToGenotypePartAssociation .

[] a owl:Restriction ;
    rdfs:subClassOf biolink:Bacterium ;
    owl:onProperty biolink:category ;
    owl:someValuesFrom biolink:Bacterium .

[] a owl:Restriction ;
    rdfs:subClassOf biolink:VariantAsAModelOfDiseaseAssociation ;
    owl:onProperty biolink:category ;
    owl:someValuesFrom biolink:VariantAsAModelOfDiseaseAssociation .

[] a owl:Restriction ;
    rdfs:subClassOf biolink:OrganismTaxon ;
    owl:onProperty biolink:category ;
    owl:someValuesFrom biolink:OrganismTaxon .

[] a owl:Restriction ;
    rdfs:subClassOf biolink:GeneToGeneCoexpressionAssociation ;
    owl:onProperty biolink:category ;
    owl:someValuesFrom biolink:GeneToGeneCoexpressionAssociation .

[] a owl:Restriction ;
    rdfs:subClassOf biolink:GeneToExpressionSiteAssociation ;
    owl:onProperty biolink:category ;
    owl:someValuesFrom biolink:GeneToExpressionSiteAssociation .

[] a owl:Restriction ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:minCardinality 1 ;
            owl:onProperty biolink:subject ],
        [ a owl:Restriction ;
            owl:allValuesFrom xsd:anyURI ;
            owl:onProperty biolink:predicate ],
        [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:predicate ],
        [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:subject ],
        [ a owl:Restriction ;
            owl:allValuesFrom biolink:NamedThing ;
            owl:onProperty biolink:object ],
        [ a owl:Restriction ;
            owl:minCardinality 1 ;
            owl:onProperty biolink:object ],
        [ a owl:Restriction ;
            owl:minCardinality 1 ;
            owl:onProperty biolink:predicate ],
        [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:object ],
        [ a owl:Restriction ;
            owl:allValuesFrom biolink:DiseaseOrPhenotypicFeature ;
            owl:onProperty biolink:subject ] ;
    owl:onProperty linkml:mixins ;
    owl:someValuesFrom biolink:DiseaseOrPhenotypicFeatureToEntityAssociationMixin .

[] a owl:Restriction ;
    rdfs:subClassOf biolink:CellLineAsAModelOfDiseaseAssociation ;
    owl:onProperty biolink:category ;
    owl:someValuesFrom biolink:CellLineAsAModelOfDiseaseAssociation .

[] a owl:Restriction ;
    rdfs:subClassOf biolink:ChemicalOrDrugOrTreatmentToDiseaseOrPhenotypicFeatureAssociation ;
    owl:onProperty biolink:category ;
    owl:someValuesFrom biolink:ChemicalOrDrugOrTreatmentToDiseaseOrPhenotypicFeatureAssociation .

[] a owl:Restriction ;
    rdfs:subClassOf biolink:GenomicSequenceLocalization ;
    owl:onProperty biolink:category ;
    owl:someValuesFrom biolink:GenomicSequenceLocalization .

[] a owl:Restriction ;
    rdfs:subClassOf biolink:GeneToPhenotypicFeatureAssociation ;
    owl:onProperty biolink:category ;
    owl:someValuesFrom biolink:GeneToPhenotypicFeatureAssociation .

[] a owl:Restriction ;
    rdfs:subClassOf biolink:DatasetVersion ;
    owl:onProperty biolink:category ;
    owl:someValuesFrom biolink:DatasetVersion .

[] a owl:Restriction ;
    rdfs:subClassOf biolink:PairwiseMolecularInteraction ;
    owl:onProperty biolink:category ;
    owl:someValuesFrom biolink:PairwiseMolecularInteraction .

[] a owl:Restriction ;
    rdfs:subClassOf biolink:StudyResult ;
    owl:onProperty biolink:category ;
    owl:someValuesFrom biolink:StudyResult .

[] a owl:Restriction ;
    rdfs:subClassOf biolink:EnvironmentalFeature ;
    owl:onProperty biolink:category ;
    owl:someValuesFrom biolink:EnvironmentalFeature .

[] a owl:Restriction ;
    rdfs:subClassOf biolink:ClinicalTrial ;
    owl:onProperty biolink:category ;
    owl:someValuesFrom biolink:ClinicalTrial .

[] a owl:Restriction ;
    rdfs:subClassOf biolink:Onset ;
    owl:onProperty biolink:category ;
    owl:someValuesFrom biolink:Onset .

[] a owl:Restriction ;
    rdfs:subClassOf biolink:MicroRNA ;
    owl:onProperty biolink:category ;
    owl:someValuesFrom biolink:MicroRNA .

[] a owl:Restriction ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:minCardinality 0 ;
            owl:onProperty biolink:synonym ],
        [ a owl:Restriction ;
            owl:allValuesFrom xsd:string ;
            owl:onProperty biolink:synonym ],
        [ a owl:Restriction ;
            owl:allValuesFrom xsd:anyURI ;
            owl:onProperty biolink:xref ],
        [ a owl:Restriction ;
            owl:minCardinality 0 ;
            owl:onProperty biolink:xref ] ;
    owl:onProperty linkml:mixins ;
    owl:someValuesFrom biolink:GeneProductMixin .

[] a owl:Restriction ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:minCardinality 1 ;
            owl:onProperty biolink:subject ],
        [ a owl:Restriction ;
            owl:allValuesFrom biolink:NamedThing ;
            owl:onProperty biolink:object ],
        [ a owl:Restriction ;
            owl:allValuesFrom biolink:GeneOrGeneProduct ;
            owl:onProperty biolink:subject ],
        [ a owl:Restriction ;
            owl:minCardinality 1 ;
            owl:onProperty biolink:predicate ],
        [ a owl:Restriction ;
            owl:allValuesFrom xsd:anyURI ;
            owl:onProperty biolink:predicate ],
        [ a owl:Restriction ;
            owl:minCardinality 1 ;
            owl:onProperty biolink:object ],
        [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:predicate ],
        [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:object ],
        [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:subject ] ;
    owl:onProperty linkml:mixins ;
    owl:someValuesFrom biolink:GeneToEntityAssociationMixin .

[] a owl:Restriction ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:minCardinality 0 ;
            owl:onProperty biolink:regulatory_approvals ],
        [ a owl:Restriction ;
            owl:allValuesFrom biolink:ClinicalApprovalStatusEnum ;
            owl:onProperty biolink:clinical_approval_status ],
        [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:number_of_cases ],
        [ a owl:Restriction ;
            owl:allValuesFrom xsd:string ;
            owl:onProperty biolink:number_of_cases ],
        [ a owl:Restriction ;
            owl:minCardinality 0 ;
            owl:onProperty biolink:number_of_cases ],
        [ a owl:Restriction ;
            owl:allValuesFrom xsd:string ;
            owl:onProperty biolink:regulatory_approvals ],
        [ a owl:Restriction ;
            owl:allValuesFrom biolink:ResearchPhaseEnum ;
            owl:onProperty biolink:max_research_phase ],
        [ a owl:Restriction ;
            owl:minCardinality 0 ;
            owl:onProperty biolink:clinical_approval_status ],
        [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:clinical_approval_status ],
        [ a owl:Restriction ;
            owl:minCardinality 0 ;
            owl:onProperty biolink:max_research_phase ],
        [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:max_research_phase ] ;
    owl:onProperty linkml:mixins ;
    owl:someValuesFrom biolink:ClinicalTrialAndRegulatoryApprovalContextMixin .

[] a owl:Restriction ;
    rdfs:subClassOf biolink:ChemicalGeneInteractionAssociation ;
    owl:onProperty biolink:category ;
    owl:someValuesFrom biolink:ChemicalGeneInteractionAssociation .

[] a owl:Restriction ;
    rdfs:subClassOf biolink:OrganismAttribute ;
    owl:onProperty biolink:category ;
    owl:someValuesFrom biolink:OrganismAttribute .

[] a owl:Restriction ;
    owl:onProperty linkml:mixins ;
    owl:someValuesFrom biolink:PathologicalEntityMixin .

[] a owl:Restriction ;
    rdfs:subClassOf biolink:CaseToDiseaseAssociation ;
    owl:onProperty biolink:category ;
    owl:someValuesFrom biolink:CaseToDiseaseAssociation .

[] a owl:Restriction ;
    rdfs:subClassOf biolink:VariantToPopulationAssociation ;
    owl:onProperty biolink:category ;
    owl:someValuesFrom biolink:VariantToPopulationAssociation .

[] a owl:Restriction ;
    rdfs:subClassOf biolink:PhysiologicalProcess ;
    owl:onProperty biolink:category ;
    owl:someValuesFrom biolink:PhysiologicalProcess .

[] a owl:Restriction ;
    rdfs:subClassOf biolink:ChemicalEntityAssessesNamedThingAssociation ;
    owl:onProperty biolink:category ;
    owl:someValuesFrom biolink:ChemicalEntityAssessesNamedThingAssociation .

[] a owl:Restriction ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:allValuesFrom xsd:anyURI ;
            owl:onProperty biolink:predicate ],
        [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:object ],
        [ a owl:Restriction ;
            owl:allValuesFrom biolink:NamedThing ;
            owl:onProperty biolink:subject ],
        [ a owl:Restriction ;
            owl:minCardinality 1 ;
            owl:onProperty biolink:object ],
        [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:subject ],
        [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:predicate ],
        [ a owl:Restriction ;
            owl:minCardinality 1 ;
            owl:onProperty biolink:subject ],
        [ a owl:Restriction ;
            owl:allValuesFrom biolink:Outcome ;
            owl:onProperty biolink:object ],
        [ a owl:Restriction ;
            owl:minCardinality 1 ;
            owl:onProperty biolink:predicate ] ;
    owl:onProperty linkml:mixins ;
    owl:someValuesFrom biolink:EntityToOutcomeAssociationMixin .

[] rdfs:subClassOf [ a owl:Restriction ;
            owl:onProperty biolink:effect_size ;
            owl:someValuesFrom xsd:string ] ;
    owl:intersectionOf ( [ a owl:Restriction ;
                owl:onProperty biolink:effect_type ;
                owl:someValuesFrom xsd:string ] biolink:Association ) .

[] a owl:Restriction ;
    rdfs:subClassOf biolink:JournalArticle ;
    owl:onProperty biolink:category ;
    owl:someValuesFrom biolink:JournalArticle .

[] a owl:Restriction ;
    rdfs:subClassOf biolink:Behavior ;
    owl:onProperty biolink:category ;
    owl:someValuesFrom biolink:Behavior .

[] a owl:Restriction ;
    rdfs:subClassOf biolink:VariantToGeneExpressionAssociation ;
    owl:onProperty biolink:category ;
    owl:someValuesFrom biolink:VariantToGeneExpressionAssociation .

[] a owl:Restriction ;
    rdfs:subClassOf biolink:EnvironmentalProcess ;
    owl:onProperty biolink:category ;
    owl:someValuesFrom biolink:EnvironmentalProcess .

[] a owl:Restriction ;
    rdfs:subClassOf biolink:Patent ;
    owl:onProperty biolink:category ;
    owl:someValuesFrom biolink:Patent .

[] a owl:Restriction ;
    rdfs:subClassOf biolink:GeneToGoTermAssociation ;
    owl:onProperty biolink:category ;
    owl:someValuesFrom biolink:GeneToGoTermAssociation .

[] a owl:Restriction ;
    rdfs:subClassOf biolink:MolecularActivityToMolecularActivityAssociation ;
    owl:onProperty biolink:category ;
    owl:someValuesFrom biolink:MolecularActivityToMolecularActivityAssociation .

[] a owl:Restriction ;
    rdfs:subClassOf biolink:CellularComponent ;
    owl:onProperty biolink:category ;
    owl:someValuesFrom biolink:CellularComponent .

[] a owl:Restriction ;
    rdfs:subClassOf biolink:CellLineToDiseaseOrPhenotypicFeatureAssociation ;
    owl:onProperty biolink:category ;
    owl:someValuesFrom biolink:CellLineToDiseaseOrPhenotypicFeatureAssociation .

[] a owl:Restriction ;
    rdfs:subClassOf biolink:Attribute ;
    owl:onProperty biolink:category ;
    owl:someValuesFrom biolink:Attribute .

[] a owl:Restriction ;
    rdfs:subClassOf biolink:PathologicalAnatomicalStructure ;
    owl:onProperty biolink:category ;
    owl:someValuesFrom biolink:PathologicalAnatomicalStructure .

[] a owl:Restriction ;
    rdfs:subClassOf biolink:BiologicalProcessOrActivityToAnatomicalEntityAssociation ;
    owl:onProperty biolink:category ;
    owl:someValuesFrom biolink:BiologicalProcessOrActivityToAnatomicalEntityAssociation .

[] a owl:Restriction ;
    rdfs:subClassOf biolink:LifeStage ;
    owl:onProperty biolink:category ;
    owl:someValuesFrom biolink:LifeStage .

[] a owl:Restriction ;
    rdfs:subClassOf biolink:ChemicalGeneSensitivityAssociation ;
    owl:onProperty biolink:category ;
    owl:someValuesFrom biolink:ChemicalGeneSensitivityAssociation .

[] a owl:Restriction ;
    rdfs:subClassOf biolink:DiseaseOrPhenotypicFeature ;
    owl:onProperty biolink:category ;
    owl:someValuesFrom biolink:DiseaseOrPhenotypicFeature .

[] a owl:Restriction ;
    owl:onProperty linkml:mixins ;
    owl:someValuesFrom biolink:PhysicalEssence .

[] a owl:Restriction ;
    rdfs:subClassOf biolink:Snv ;
    owl:onProperty biolink:category ;
    owl:someValuesFrom biolink:Snv .

[] a owl:Restriction ;
    owl:onProperty linkml:mixins ;
    owl:someValuesFrom biolink:ChemicalOrDrugOrTreatment .

[] a owl:Restriction ;
    owl:onProperty linkml:mixins ;
    owl:someValuesFrom biolink:GeneProductIsoformMixin .

[] a owl:Restriction ;
    rdfs:subClassOf biolink:Treatment ;
    owl:onProperty biolink:category ;
    owl:someValuesFrom biolink:Treatment .

[] a owl:Restriction ;
    owl:onProperty linkml:mixins ;
    owl:someValuesFrom biolink:Occurrent .

[] a owl:Restriction ;
    rdfs:subClassOf biolink:ProteinLigandAssayResult ;
    owl:onProperty biolink:category ;
    owl:someValuesFrom biolink:ProteinLigandAssayResult .

[] a owl:Restriction ;
    rdfs:subClassOf biolink:Invertebrate ;
    owl:onProperty biolink:category ;
    owl:someValuesFrom biolink:Invertebrate .

[] a owl:Restriction ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:allValuesFrom biolink:Disease ;
            owl:onProperty biolink:subject ],
        [ a owl:Restriction ;
            owl:allValuesFrom xsd:anyURI ;
            owl:onProperty biolink:predicate ],
        [ a owl:Restriction ;
            owl:minCardinality 1 ;
            owl:onProperty biolink:object ],
        [ a owl:Restriction ;
            owl:minCardinality 1 ;
            owl:onProperty biolink:predicate ],
        [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:subject ],
        [ a owl:Restriction ;
            owl:minCardinality 1 ;
            owl:onProperty biolink:subject ],
        [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:predicate ],
        [ a owl:Restriction ;
            owl:allValuesFrom biolink:NamedThing ;
            owl:onProperty biolink:object ],
        [ a owl:Restriction ;
            owl:maxCardinality 1 ;
            owl:onProperty biolink:object ] ;
    owl:onProperty linkml:mixins ;
    owl:someValuesFrom biolink:DiseaseToEntityAssociationMixin .

[] a owl:Restriction ;
    rdfs:subClassOf biolink:Article ;
    owl:onProperty biolink:category ;
    owl:someValuesFrom biolink:Article .

[] a owl:Restriction ;
    rdfs:subClassOf biolink:DiseaseToDiseaseAssociation ;
    owl:onProperty biolink:category ;
    owl:someValuesFrom biolink:DiseaseToDiseaseAssociation .

[] a owl:Restriction ;
    rdfs:subClassOf biolink:ChemicalAffectsBiologicalEntityAssociation ;
    owl:onProperty biolink:category ;
    owl:someValuesFrom biolink:ChemicalAffectsBiologicalEntityAssociation .

[] a owl:Restriction ;
    rdfs:subClassOf biolink:ClinicalModifier ;
    owl:onProperty biolink:category ;
    owl:someValuesFrom biolink:ClinicalModifier .

[] a owl:Restriction ;
    rdfs:subClassOf biolink:SmallMolecule ;
    owl:onProperty biolink:category ;
    owl:someValuesFrom biolink:SmallMolecule .

[] a owl:Restriction ;
    rdfs:subClassOf biolink:Device ;
    owl:onProperty biolink:category ;
    owl:someValuesFrom biolink:Device .

[] a owl:Restriction ;
    rdfs:subClassOf biolink:GenotypicSex ;
    owl:onProperty biolink:category ;
    owl:someValuesFrom biolink:GenotypicSex .

[] a owl:Restriction ;
    rdfs:subClassOf biolink:BehavioralExposure ;
    owl:onProperty biolink:category ;
    owl:someValuesFrom biolink:BehavioralExposure .

[] a owl:Restriction ;
    rdfs:subClassOf biolink:PopulationToPopulationAssociation ;
    owl:onProperty biolink:category ;
    owl:someValuesFrom biolink:PopulationToPopulationAssociation .

[] a owl:Restriction ;
    rdfs:subClassOf biolink:Plant ;
    owl:onProperty biolink:category ;
    owl:someValuesFrom biolink:Plant .

[] a owl:Restriction ;
    rdfs:subClassOf biolink:PopulationOfIndividualOrganisms ;
    owl:onProperty biolink:category ;
    owl:someValuesFrom biolink:PopulationOfIndividualOrganisms .

[] a owl:Restriction ;
    rdfs:subClassOf biolink:Human ;
    owl:onProperty biolink:category ;
    owl:someValuesFrom biolink:Human .

[] a owl:Restriction ;
    owl:onProperty linkml:mixins ;
    owl:someValuesFrom biolink:Outcome .

[] a owl:Restriction ;
    rdfs:subClassOf biolink:ComplexChemicalExposure ;
    owl:onProperty biolink:category ;
    owl:someValuesFrom biolink:ComplexChemicalExposure .